KEGG   Macrotis lagotis (bilby): 141522028
Entry
141522028         CDS       T11097                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mlao  Macrotis lagotis (bilby)
Pathway
mlao00562  Inositol phosphate metabolism
mlao01100  Metabolic pathways
mlao04015  Rap1 signaling pathway
mlao04020  Calcium signaling pathway
mlao04022  cGMP-PKG signaling pathway
mlao04062  Chemokine signaling pathway
mlao04070  Phosphatidylinositol signaling system
mlao04071  Sphingolipid signaling pathway
mlao04072  Phospholipase D signaling pathway
mlao04081  Hormone signaling
mlao04082  Neuroactive ligand signaling
mlao04261  Adrenergic signaling in cardiomyocytes
mlao04270  Vascular smooth muscle contraction
mlao04310  Wnt signaling pathway
mlao04371  Apelin signaling pathway
mlao04540  Gap junction
mlao04611  Platelet activation
mlao04613  Neutrophil extracellular trap formation
mlao04621  NOD-like receptor signaling pathway
mlao04713  Circadian entrainment
mlao04720  Long-term potentiation
mlao04723  Retrograde endocannabinoid signaling
mlao04724  Glutamatergic synapse
mlao04725  Cholinergic synapse
mlao04726  Serotonergic synapse
mlao04728  Dopaminergic synapse
mlao04730  Long-term depression
mlao04742  Taste transduction
mlao04750  Inflammatory mediator regulation of TRP channels
mlao04911  Insulin secretion
mlao04912  GnRH signaling pathway
mlao04915  Estrogen signaling pathway
mlao04916  Melanogenesis
mlao04918  Thyroid hormone synthesis
mlao04919  Thyroid hormone signaling pathway
mlao04921  Oxytocin signaling pathway
mlao04922  Glucagon signaling pathway
mlao04924  Renin secretion
mlao04925  Aldosterone synthesis and secretion
mlao04926  Relaxin signaling pathway
mlao04927  Cortisol synthesis and secretion
mlao04928  Parathyroid hormone synthesis, secretion and action
mlao04929  GnRH secretion
mlao04933  AGE-RAGE signaling pathway in diabetic complications
mlao04934  Cushing syndrome
mlao04935  Growth hormone synthesis, secretion and action
mlao04961  Endocrine and other factor-regulated calcium reabsorption
mlao04970  Salivary secretion
mlao04971  Gastric acid secretion
mlao04972  Pancreatic secretion
mlao04973  Carbohydrate digestion and absorption
mlao05010  Alzheimer disease
mlao05016  Huntington disease
mlao05017  Spinocerebellar ataxia
mlao05022  Pathways of neurodegeneration - multiple diseases
mlao05142  Chagas disease
mlao05143  African trypanosomiasis
mlao05146  Amoebiasis
mlao05163  Human cytomegalovirus infection
mlao05200  Pathways in cancer
mlao05415  Diabetic cardiomyopathy
mlao05417  Lipid and atherosclerosis
Module
mlao_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlao00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    141522028 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    141522028 (PLCB2)
   04310 Wnt signaling pathway
    141522028 (PLCB2)
   04371 Apelin signaling pathway
    141522028 (PLCB2)
   04020 Calcium signaling pathway
    141522028 (PLCB2)
   04070 Phosphatidylinositol signaling system
    141522028 (PLCB2)
   04072 Phospholipase D signaling pathway
    141522028 (PLCB2)
   04071 Sphingolipid signaling pathway
    141522028 (PLCB2)
   04022 cGMP-PKG signaling pathway
    141522028 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    141522028 (PLCB2)
   04081 Hormone signaling
    141522028 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    141522028 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    141522028 (PLCB2)
   04613 Neutrophil extracellular trap formation
    141522028 (PLCB2)
   04621 NOD-like receptor signaling pathway
    141522028 (PLCB2)
   04062 Chemokine signaling pathway
    141522028 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    141522028 (PLCB2)
   04922 Glucagon signaling pathway
    141522028 (PLCB2)
   04929 GnRH secretion
    141522028 (PLCB2)
   04912 GnRH signaling pathway
    141522028 (PLCB2)
   04915 Estrogen signaling pathway
    141522028 (PLCB2)
   04921 Oxytocin signaling pathway
    141522028 (PLCB2)
   04926 Relaxin signaling pathway
    141522028 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    141522028 (PLCB2)
   04918 Thyroid hormone synthesis
    141522028 (PLCB2)
   04919 Thyroid hormone signaling pathway
    141522028 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    141522028 (PLCB2)
   04916 Melanogenesis
    141522028 (PLCB2)
   04924 Renin secretion
    141522028 (PLCB2)
   04925 Aldosterone synthesis and secretion
    141522028 (PLCB2)
   04927 Cortisol synthesis and secretion
    141522028 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    141522028 (PLCB2)
   04270 Vascular smooth muscle contraction
    141522028 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    141522028 (PLCB2)
   04971 Gastric acid secretion
    141522028 (PLCB2)
   04972 Pancreatic secretion
    141522028 (PLCB2)
   04973 Carbohydrate digestion and absorption
    141522028 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    141522028 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    141522028 (PLCB2)
   04725 Cholinergic synapse
    141522028 (PLCB2)
   04728 Dopaminergic synapse
    141522028 (PLCB2)
   04726 Serotonergic synapse
    141522028 (PLCB2)
   04720 Long-term potentiation
    141522028 (PLCB2)
   04730 Long-term depression
    141522028 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    141522028 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    141522028 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    141522028 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    141522028 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    141522028 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    141522028 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    141522028 (PLCB2)
   05142 Chagas disease
    141522028 (PLCB2)
   05143 African trypanosomiasis
    141522028 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    141522028 (PLCB2)
   05016 Huntington disease
    141522028 (PLCB2)
   05017 Spinocerebellar ataxia
    141522028 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    141522028 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    141522028 (PLCB2)
   05415 Diabetic cardiomyopathy
    141522028 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    141522028 (PLCB2)
   04934 Cushing syndrome
    141522028 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlao04131]
    141522028 (PLCB2)
Enzymes [BR:mlao01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     141522028 (PLCB2)
Membrane trafficking [BR:mlao04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    141522028 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    141522028 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 MMACHC
Other DBs
NCBI-GeneID: 141522028
NCBI-ProteinID: XP_074091198
Position
4:complement(200316711..200356411)
AA seq 1183 aa
MSLLHPVLLPPEVKSYLTRGERFIKWDDETSVASPVILRVDPNGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVSKDWAEDVLALAKDPLAANAPRSRFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDSINPEDFPEPVYRSFLMNLCPRPEIDEIFTSHHSKAKPYMTKEH
LTKFINQKQRDARLNSLLFPPARPDQVQCLIEKYEPSGINIQRGQLSPEGMVWFLCGPEN
SIVAQDKLILHQDMSQPLNHYFINSSHNTYLTAGQFSGPSSSEMYRQVLLSGCRCVELDC
WKGKPPEEEPIITHGFTMTTDILFKDAIEAIAESAFKTSLYPVILSFENHVDSPRQQAKM
AEYCRTIFGDTLLTEPLDKFPLKPGIPLPSPQDLLGKILIKNKKNQSPAPVSPKKEPCAE
TEDSSQSCSATGEDTVWVGEEETELEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEE
MSSLVNYIQPTKFISFEFSSQKNRSYVISSFTEMKAYDLLTKSPVQFVDYNKRQMSRIYP
KGTRMDSSNYSPQMFWNAGCQMVALNFQTMDMPMQQNMALFEFNGQSGYLLKHEFMRRQD
KQFDPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVEVFGLPGDPKRRYRTKLTPN
ANSINPVWKEDPFIFEKIMMPELASLRVAVLEEGGKFIGHRIIPVHALQSGYHHLCLRSE
SNMPLTMPVLFVFLEMKDYVPDTWADLTVALANPIKFFNAQDKKSVKLKDAGNDSPEGPL
PLRNPALGQANGALTSAGSSLAPSSNGPTAAVTWFKEEVMKEASEPQTVSLEELQQLKGF
LKLQKRQEKELRELERRGSRRWEELLQKYANLQAELTPQGGCKKSVTKGSWKKRNLPWEE
ASGAGSGPVEGSESTDGRVRELKEKLETELYQQGEEQYENIMKRKEQHGMEQITKVMELA
QERQAAELKALKESAESNTKEMKKKLEIKRVERIQAMSKITSDKMAQERLKREINNSHIQ
EVVHIIKQMTETLERHQERLEEKQAACLEQIREKEKKFQQEALSAYEEQMRGLEAKVKEA
VRCCFSSPQDAHDKKLETPRAVEEPSEEGSPPTDASSQLESRL
NT seq 3552 nt   +upstreamnt  +downstreamnt
atgtctctgctccatcctgtcctgctgccccctgaagtgaagagctatctaacccgagga
gagcgcttcatcaaatgggatgatgagacttcagtggcatccccagtcatccttcgtgtg
gatcccaatggctattacttatattggacatatcaaagcaaggagatggaattcctggac
atcaccagcattcgggacactcggtttggaaagtttgctaagatgcccaagacccagaaa
cttcgggaggttttcaacttggactttcctgacaataccttcctgctgaagacattgaca
gtggtatctggcccagacatggtggacctgaccttccataactttgtttcctataaagaa
aatgtcagcaaggactgggctgaagatgttctggccttggctaaggacccattagcagct
aatgccccccggagcagattcctggataagatcctagtaaaactcaagatgcagcttaat
ccagaaggaaagatccctgtgaagaatttttttcagatgtttcctgctgaccggaaacga
gttgaggctgccctcagtgcctgtcatcttcccaagggcaaaaatgattccatcaaccct
gaggatttccctgagcctgtctacagaagttttctaatgaatctatgtccccgacctgaa
atcgatgagatcttcacctctcatcattccaaagcaaagccttacatgaccaaggagcat
ctgaccaaattcatcaaccaaaaacagcgtgatgcccggctcaactcccttctcttccca
ccagcccgacctgatcaagtgcaatgcctcattgaaaagtatgagcccagtggcatcaac
attcaaaggggccagctatccccagaggggatggtttggtttctctgtggtccggagaac
agcatagtagcccaggacaagttgatactgcaccaggacatgagccagcctctgaatcac
tacttcatcaactcctcccacaatacttatctcacagctggtcagttctcaggaccctca
tcctcagagatgtacagacaggttttgctctctggctgccgatgtgtagaacttgactgt
tggaaagggaagcctcctgaggaagagccgatcattactcatggtttcactatgaccaca
gacattttgttcaaggatgcaatagaggctatagctgagagtgcctttaagacctcactg
taccctgtcatcctgtcttttgaaaatcatgtggactcgccccgacagcaggccaagatg
gcggagtactgccggaccatatttggggacacactcctcacagagcccctggacaagttc
cctttgaagccaggaattcccctccctagtccccaggacttactgggcaagattctcatc
aagaataagaaaaatcagtccccagctcctgtttcacctaagaaggaaccatgtgcggag
acagaagactccagccagtcctgttcagccacgggtgaggacacagtgtgggttggtgaa
gaagagactgagctggaggaagaggaagaggaagaatcaggtaacttggatgaagaggaa
ataaagaagatgcagtcggatgagggcacagctggcctggaggtgacagcatatgaagag
atgtctagtctggtcaactacatacaacccaccaagttcatctccttcgagttctcctcc
cagaagaatcggagttatgtcatctcttccttcacggagatgaaggcctatgacctgctc
accaagtcccctgtgcagtttgtggattacaataagcgtcagatgagtaggatctacccc
aagggcacccgaatggattcatctaactactctccccagatgttctggaatgcaggctgc
caaatggttgctctaaattttcagactatggatatgcccatgcagcagaacatggcattg
tttgagttcaacggacagagtggctaccttctcaaacatgagttcatgcgccgacaagac
aagcaattcgaccccttctctgtggaccgaattgatgtggtggtggctacgactctctcc
atcacggttatttctgggcagtttctgtcagaacgaagtgttcgaacttatgtggaggtg
gaggtatttggcttgcctggagaccccaagagacgctaccgcaccaaactgacacccaat
gccaactctataaatcctgtctggaaagaggacccctttatctttgagaagatcatgatg
ccagagctggcctctctgagagtggcagtactagaggaaggcggcaaattcattgggcat
cgaattatcccagtccatgccctacagtcaggataccatcacctgtgcctcaggagtgag
agcaacatgcccctcaccatgcctgtgctctttgtttttctggagatgaaagattatgtt
cctgatacctgggcagatctgactgtggctcttgccaaccccatcaaattcttcaatgca
caagacaagaaatcagtaaagctgaaggatgcagggaatgactcacctgaggggcctttg
ccactcaggaacccagctcttggccaggccaatggggccctcacctcagcaggttcctct
ttggccccatcatccaatggtcccacagcagctgtgacctggttcaaggaagaagtaatg
aaagaggcatcagaacctcagacagtcagcttggaagagttgcaacaattgaaagggttc
ctgaagcttcagaagagacaagaaaaggaacttcgggaattggagaggcggggatctcga
cgatgggaggaactcctgcaaaagtatgccaacctacaggctgaactgaccccacagggt
ggatgcaagaagtctgtcacaaagggatcctggaagaagagaaatttgccttgggaggag
gctagtggagctgggtcggggccagtcgaggggtcagaaagcacagatgggcgtgttcga
gagctgaaggagaaactggagacagaattgtaccagcaaggggaggagcagtatgaaaac
atcatgaaacgcaaggaacagcatggcatggagcaaatcaccaaggtgatggagctggcc
caggagagacaagcagctgagctaaaggccctaaaggaatctgcagaaagcaacaccaaa
gagatgaagaagaagcttgaaatcaagagggtagagcggattcaggccatgagcaagatc
accagtgataagatggcccaggagaggttgaagagagagattaacaactcacacatacag
gaagtggttcacatcatcaaacagatgacagagaccctggagagacaccaggagaggctg
gaagaaaagcaggctgcctgtttggagcagatccgggagaaagagaaaaagttccagcaa
gaggcattgtctgcatatgaggaacagatgaggggcctggaggctaaggtgaaggaggca
gtgaggtgctgcttcagttccccgcaagatgcccatgacaagaagctggagacccccagg
gctgtggaggaaccttcagaggagggatctcccccaacagatgcctcctcccagctagaa
agccgtctctag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (8)   
   Pfam (8)   
All databases (14)   

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