KEGG   Mustela lutreola (European mink): 131808069
Entry
131808069         CDS       T09578                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk00562  Inositol phosphate metabolism
mlk01100  Metabolic pathways
mlk04015  Rap1 signaling pathway
mlk04020  Calcium signaling pathway
mlk04022  cGMP-PKG signaling pathway
mlk04062  Chemokine signaling pathway
mlk04070  Phosphatidylinositol signaling system
mlk04071  Sphingolipid signaling pathway
mlk04072  Phospholipase D signaling pathway
mlk04081  Hormone signaling
mlk04082  Neuroactive ligand signaling
mlk04261  Adrenergic signaling in cardiomyocytes
mlk04270  Vascular smooth muscle contraction
mlk04310  Wnt signaling pathway
mlk04371  Apelin signaling pathway
mlk04540  Gap junction
mlk04611  Platelet activation
mlk04613  Neutrophil extracellular trap formation
mlk04621  NOD-like receptor signaling pathway
mlk04713  Circadian entrainment
mlk04720  Long-term potentiation
mlk04723  Retrograde endocannabinoid signaling
mlk04724  Glutamatergic synapse
mlk04725  Cholinergic synapse
mlk04726  Serotonergic synapse
mlk04728  Dopaminergic synapse
mlk04730  Long-term depression
mlk04742  Taste transduction
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04911  Insulin secretion
mlk04912  GnRH signaling pathway
mlk04915  Estrogen signaling pathway
mlk04916  Melanogenesis
mlk04918  Thyroid hormone synthesis
mlk04919  Thyroid hormone signaling pathway
mlk04921  Oxytocin signaling pathway
mlk04922  Glucagon signaling pathway
mlk04924  Renin secretion
mlk04925  Aldosterone synthesis and secretion
mlk04926  Relaxin signaling pathway
mlk04927  Cortisol synthesis and secretion
mlk04928  Parathyroid hormone synthesis, secretion and action
mlk04929  GnRH secretion
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04934  Cushing syndrome
mlk04935  Growth hormone synthesis, secretion and action
mlk04961  Endocrine and other factor-regulated calcium reabsorption
mlk04970  Salivary secretion
mlk04971  Gastric acid secretion
mlk04972  Pancreatic secretion
mlk04973  Carbohydrate digestion and absorption
mlk05010  Alzheimer disease
mlk05016  Huntington disease
mlk05017  Spinocerebellar ataxia
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05142  Chagas disease
mlk05143  African trypanosomiasis
mlk05146  Amoebiasis
mlk05163  Human cytomegalovirus infection
mlk05200  Pathways in cancer
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
Module
mlk_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    131808069 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    131808069 (PLCB1)
   04310 Wnt signaling pathway
    131808069 (PLCB1)
   04371 Apelin signaling pathway
    131808069 (PLCB1)
   04020 Calcium signaling pathway
    131808069 (PLCB1)
   04070 Phosphatidylinositol signaling system
    131808069 (PLCB1)
   04072 Phospholipase D signaling pathway
    131808069 (PLCB1)
   04071 Sphingolipid signaling pathway
    131808069 (PLCB1)
   04022 cGMP-PKG signaling pathway
    131808069 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    131808069 (PLCB1)
   04081 Hormone signaling
    131808069 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    131808069 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131808069 (PLCB1)
   04613 Neutrophil extracellular trap formation
    131808069 (PLCB1)
   04621 NOD-like receptor signaling pathway
    131808069 (PLCB1)
   04062 Chemokine signaling pathway
    131808069 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    131808069 (PLCB1)
   04922 Glucagon signaling pathway
    131808069 (PLCB1)
   04929 GnRH secretion
    131808069 (PLCB1)
   04912 GnRH signaling pathway
    131808069 (PLCB1)
   04915 Estrogen signaling pathway
    131808069 (PLCB1)
   04921 Oxytocin signaling pathway
    131808069 (PLCB1)
   04926 Relaxin signaling pathway
    131808069 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    131808069 (PLCB1)
   04918 Thyroid hormone synthesis
    131808069 (PLCB1)
   04919 Thyroid hormone signaling pathway
    131808069 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    131808069 (PLCB1)
   04916 Melanogenesis
    131808069 (PLCB1)
   04924 Renin secretion
    131808069 (PLCB1)
   04925 Aldosterone synthesis and secretion
    131808069 (PLCB1)
   04927 Cortisol synthesis and secretion
    131808069 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    131808069 (PLCB1)
   04270 Vascular smooth muscle contraction
    131808069 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    131808069 (PLCB1)
   04971 Gastric acid secretion
    131808069 (PLCB1)
   04972 Pancreatic secretion
    131808069 (PLCB1)
   04973 Carbohydrate digestion and absorption
    131808069 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    131808069 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    131808069 (PLCB1)
   04725 Cholinergic synapse
    131808069 (PLCB1)
   04728 Dopaminergic synapse
    131808069 (PLCB1)
   04726 Serotonergic synapse
    131808069 (PLCB1)
   04720 Long-term potentiation
    131808069 (PLCB1)
   04730 Long-term depression
    131808069 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    131808069 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    131808069 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    131808069 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    131808069 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131808069 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    131808069 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    131808069 (PLCB1)
   05142 Chagas disease
    131808069 (PLCB1)
   05143 African trypanosomiasis
    131808069 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131808069 (PLCB1)
   05016 Huntington disease
    131808069 (PLCB1)
   05017 Spinocerebellar ataxia
    131808069 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    131808069 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131808069 (PLCB1)
   05415 Diabetic cardiomyopathy
    131808069 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    131808069 (PLCB1)
   04934 Cushing syndrome
    131808069 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlk04131]
    131808069 (PLCB1)
Enzymes [BR:mlk01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     131808069 (PLCB1)
Membrane trafficking [BR:mlk04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    131808069 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    131808069 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 131808069
NCBI-ProteinID: XP_058989961
Position
9:33608716..34291473
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSIKAPVKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHRPPSS
DELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggaccgatcaaaacaaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcatgccaaagct
cccaaggaccccaagttacgtgaacttttggatgtggggaacatcgggcgcctggagcat
cgtatgataaccgtggtgtatgggcctgacttggttaacatctcccatttgaatctcgtg
gctttccaagaagaagtagccaaggagtggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaatatgtcaagagacgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaaacgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtatacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
actgttgatcagatgatggactttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaaccc
aacaatagtctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcaa
cccctctctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgtcgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccacgggttt
accatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacataagtcgtcggaaggaagtggcaaaaag
aagctctcagaacaagcctccaacacgtacagtgactcctccagcatgttcgagccctcg
tctcccggagccggggaagcggacactgagagtgacgacgacgacgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgccgggagcgaggccatggccactgaagagatg
tctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggccttgagcaactgacg
aagtctcccgtggaatttgtagaatataacaaaatgcagcttagcaggatatatccgaaa
ggaacccgtgtggattcatcgaactacatgcctcagctcttctggaatgcaggttgccaa
atggttgcccttaattttcaaactgtggacctcgctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaaaccagagttcatgaggagacctgacaag
cattttgatcccttcaccgaaggcatcgtggatgggatagtggccaacactttatctgtc
aagattatttcaggtcagtttctttccgataagaaagtcgggacttacgtagaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcccgtctgggaagaagagcccattgtgttcaaaaaggtggtccttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaattcattggtcaccgg
atcttgccagtacaagcaattcggccaggctatcactacatctgcctgaggaatgaaagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtcccc
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctcatg
gagcaaagagctaaacagttagctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccttggcacccaaaccaccatcccaggctctccac
agccaaccagctccaggttctataaaggcacctgtgaaaacagaagaccttattcagagt
gtcctaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcctttgta
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accactgaccttatcaaagaacacactacaaaatataatgagattcagaacgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagatccc
agcagtcctgaccatggttcatcaacgattgaacaagatcttgctgccctagatgctgaa
atgacccaaaagttaatagacttgaaagacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaatatcagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaataatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggagttaaagaagaagatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccga
tcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcaacagatcctggacgaaaagccc
aagctgcagacagacctggagcaagaataccaagacaagttcaaaagactgcccctggag
atcttggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagcaaccacagc
tctgcccctccctccctggcctcagagcctggaaaaatgaaccacaggcctccctccagt
gacgagctggaaggagacaacccaggaaaagagttcgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (6)   
   Pfam (6)   
All databases (16)   

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