KEGG   Martes martes (European pine marten): 308348962
Entry
308348962         CDS       T12008                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmaq  Martes martes (European pine marten)
Pathway
mmaq00562  Inositol phosphate metabolism
mmaq01100  Metabolic pathways
mmaq04015  Rap1 signaling pathway
mmaq04020  Calcium signaling pathway
mmaq04022  cGMP-PKG signaling pathway
mmaq04062  Chemokine signaling pathway
mmaq04070  Phosphatidylinositol signaling system
mmaq04071  Sphingolipid signaling pathway
mmaq04072  Phospholipase D signaling pathway
mmaq04081  Hormone signaling
mmaq04082  Neuroactive ligand signaling
mmaq04261  Adrenergic signaling in cardiomyocytes
mmaq04270  Vascular smooth muscle contraction
mmaq04310  Wnt signaling pathway
mmaq04371  Apelin signaling pathway
mmaq04540  Gap junction
mmaq04611  Platelet activation
mmaq04613  Neutrophil extracellular trap formation
mmaq04621  NOD-like receptor signaling pathway
mmaq04713  Circadian entrainment
mmaq04720  Long-term potentiation
mmaq04723  Retrograde endocannabinoid signaling
mmaq04724  Glutamatergic synapse
mmaq04725  Cholinergic synapse
mmaq04726  Serotonergic synapse
mmaq04728  Dopaminergic synapse
mmaq04730  Long-term depression
mmaq04742  Taste transduction
mmaq04750  Inflammatory mediator regulation of TRP channels
mmaq04911  Insulin secretion
mmaq04912  GnRH signaling pathway
mmaq04915  Estrogen signaling pathway
mmaq04916  Melanogenesis
mmaq04918  Thyroid hormone synthesis
mmaq04919  Thyroid hormone signaling pathway
mmaq04921  Oxytocin signaling pathway
mmaq04922  Glucagon signaling pathway
mmaq04924  Renin secretion
mmaq04925  Aldosterone synthesis and secretion
mmaq04926  Relaxin signaling pathway
mmaq04927  Cortisol synthesis and secretion
mmaq04928  Parathyroid hormone synthesis, secretion and action
mmaq04929  GnRH secretion
mmaq04933  AGE-RAGE signaling pathway in diabetic complications
mmaq04934  Cushing syndrome
mmaq04935  Growth hormone synthesis, secretion and action
mmaq04961  Endocrine and other factor-regulated calcium reabsorption
mmaq04970  Salivary secretion
mmaq04971  Gastric acid secretion
mmaq04972  Pancreatic secretion
mmaq04973  Carbohydrate digestion and absorption
mmaq05010  Alzheimer disease
mmaq05016  Huntington disease
mmaq05017  Spinocerebellar ataxia
mmaq05022  Pathways of neurodegeneration - multiple diseases
mmaq05142  Chagas disease
mmaq05143  African trypanosomiasis
mmaq05146  Amoebiasis
mmaq05163  Human cytomegalovirus infection
mmaq05200  Pathways in cancer
mmaq05415  Diabetic cardiomyopathy
mmaq05417  Lipid and atherosclerosis
Module
mmaq_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmaq00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    308348962 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    308348962 (PLCB4)
   04310 Wnt signaling pathway
    308348962 (PLCB4)
   04371 Apelin signaling pathway
    308348962 (PLCB4)
   04020 Calcium signaling pathway
    308348962 (PLCB4)
   04070 Phosphatidylinositol signaling system
    308348962 (PLCB4)
   04072 Phospholipase D signaling pathway
    308348962 (PLCB4)
   04071 Sphingolipid signaling pathway
    308348962 (PLCB4)
   04022 cGMP-PKG signaling pathway
    308348962 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    308348962 (PLCB4)
   04081 Hormone signaling
    308348962 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    308348962 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    308348962 (PLCB4)
   04613 Neutrophil extracellular trap formation
    308348962 (PLCB4)
   04621 NOD-like receptor signaling pathway
    308348962 (PLCB4)
   04062 Chemokine signaling pathway
    308348962 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    308348962 (PLCB4)
   04922 Glucagon signaling pathway
    308348962 (PLCB4)
   04929 GnRH secretion
    308348962 (PLCB4)
   04912 GnRH signaling pathway
    308348962 (PLCB4)
   04915 Estrogen signaling pathway
    308348962 (PLCB4)
   04921 Oxytocin signaling pathway
    308348962 (PLCB4)
   04926 Relaxin signaling pathway
    308348962 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    308348962 (PLCB4)
   04918 Thyroid hormone synthesis
    308348962 (PLCB4)
   04919 Thyroid hormone signaling pathway
    308348962 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    308348962 (PLCB4)
   04916 Melanogenesis
    308348962 (PLCB4)
   04924 Renin secretion
    308348962 (PLCB4)
   04925 Aldosterone synthesis and secretion
    308348962 (PLCB4)
   04927 Cortisol synthesis and secretion
    308348962 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    308348962 (PLCB4)
   04270 Vascular smooth muscle contraction
    308348962 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    308348962 (PLCB4)
   04971 Gastric acid secretion
    308348962 (PLCB4)
   04972 Pancreatic secretion
    308348962 (PLCB4)
   04973 Carbohydrate digestion and absorption
    308348962 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    308348962 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    308348962 (PLCB4)
   04725 Cholinergic synapse
    308348962 (PLCB4)
   04728 Dopaminergic synapse
    308348962 (PLCB4)
   04726 Serotonergic synapse
    308348962 (PLCB4)
   04720 Long-term potentiation
    308348962 (PLCB4)
   04730 Long-term depression
    308348962 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    308348962 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    308348962 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    308348962 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    308348962 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308348962 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    308348962 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    308348962 (PLCB4)
   05142 Chagas disease
    308348962 (PLCB4)
   05143 African trypanosomiasis
    308348962 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308348962 (PLCB4)
   05016 Huntington disease
    308348962 (PLCB4)
   05017 Spinocerebellar ataxia
    308348962 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    308348962 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308348962 (PLCB4)
   05415 Diabetic cardiomyopathy
    308348962 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    308348962 (PLCB4)
   04934 Cushing syndrome
    308348962 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmaq04131]
    308348962 (PLCB4)
Enzymes [BR:mmaq01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     308348962 (PLCB4)
Membrane trafficking [BR:mmaq04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    308348962 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    308348962 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 308348962
NCBI-ProteinID: XP_080669604
Position
9:33577239..33986203
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQNSN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtccta
gaatgttccctcatcaacagtattcgattgggagccacgcccaaggatcccaaaatcctg
gctgctctcgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtt
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggactaagatcgatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcgtttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatctttcaagccctcaaggaattaggtcttcccagtggaaagaatgacgaaattgag
cctgcggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgaacccgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcacgggccggcagtttggcgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaactagac
tgttgggatggaaaaggtgaagaccaagaaccgatcataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcagcagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccgtcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccagttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtgaccgtggaagacgaacaggcatgg
atggcgtcttataaatatgtaggtgctaccactaacatccatccgtatttgtctacaatg
atcaactatgcacaacccgtaaagtttcaaggtttccatgtggctgaagagcgtaatatt
cattataacatgtcttcttttaatgagtccgtcggcctgggctacttgaagacgcacgcc
attgaatttgtgaactataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gttgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatctagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtacctcctcaaaccagatttcatgagacggcccgatcgaacattcgat
cccttctctgaaactcctgtcgatggggttattgcagccacttgctcagtccaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtacggg
ttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc
aatccagtttacaatgaagaatcatttgtgttccggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaacaggctcataggccagaggatccttcct
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaaccattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtagatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag
agcagctctgagctcagaccaaccaccacggcggccctgggatctggcgtggaagcgaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ctgaagcacttaaagaaacaacagaaggagctaaattctttaaagaagaaacacgcaaag
gagcacagcacaatgcagaagttgcactgcacacaagttgacaaaatcgtggcacagtat
gacaaagagaagtcgacgcatgagaaaatcctagagaaagcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaactgaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacgaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctacacctcagccagcagtgtgag
ctcctgagaaaactactgatcaatgcccatgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcgcaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctcgagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccaaaattcaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (13)   

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