KEGG   Micromys minutus (European harvest mouse): 308434570
Entry
308434570         CDS       T12044                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mmiu  Micromys minutus (European harvest mouse)
Pathway
mmiu00562  Inositol phosphate metabolism
mmiu01100  Metabolic pathways
mmiu01521  EGFR tyrosine kinase inhibitor resistance
mmiu01522  Endocrine resistance
mmiu01524  Platinum drug resistance
mmiu04012  ErbB signaling pathway
mmiu04014  Ras signaling pathway
mmiu04015  Rap1 signaling pathway
mmiu04024  cAMP signaling pathway
mmiu04062  Chemokine signaling pathway
mmiu04066  HIF-1 signaling pathway
mmiu04068  FoxO signaling pathway
mmiu04070  Phosphatidylinositol signaling system
mmiu04071  Sphingolipid signaling pathway
mmiu04072  Phospholipase D signaling pathway
mmiu04081  Hormone signaling
mmiu04140  Autophagy - animal
mmiu04145  Phagocytosis
mmiu04150  mTOR signaling pathway
mmiu04151  PI3K-Akt signaling pathway
mmiu04152  AMPK signaling pathway
mmiu04210  Apoptosis
mmiu04211  Longevity regulating pathway
mmiu04213  Longevity regulating pathway - multiple species
mmiu04218  Cellular senescence
mmiu04360  Axon guidance
mmiu04370  VEGF signaling pathway
mmiu04380  Osteoclast differentiation
mmiu04510  Focal adhesion
mmiu04517  IgSF CAM signaling
mmiu04518  Integrin signaling
mmiu04550  Signaling pathways regulating pluripotency of stem cells
mmiu04611  Platelet activation
mmiu04613  Neutrophil extracellular trap formation
mmiu04620  Toll-like receptor signaling pathway
mmiu04625  C-type lectin receptor signaling pathway
mmiu04630  JAK-STAT signaling pathway
mmiu04650  Natural killer cell mediated cytotoxicity
mmiu04660  T cell receptor signaling pathway
mmiu04662  B cell receptor signaling pathway
mmiu04664  Fc epsilon RI signaling pathway
mmiu04666  Fc gamma R-mediated phagosome formation
mmiu04668  TNF signaling pathway
mmiu04670  Leukocyte transendothelial migration
mmiu04722  Neurotrophin signaling pathway
mmiu04725  Cholinergic synapse
mmiu04750  Inflammatory mediator regulation of TRP channels
mmiu04810  Regulation of actin cytoskeleton
mmiu04910  Insulin signaling pathway
mmiu04914  Progesterone-mediated oocyte maturation
mmiu04915  Estrogen signaling pathway
mmiu04917  Prolactin signaling pathway
mmiu04919  Thyroid hormone signaling pathway
mmiu04923  Regulation of lipolysis in adipocytes
mmiu04926  Relaxin signaling pathway
mmiu04929  GnRH secretion
mmiu04930  Type II diabetes mellitus
mmiu04931  Insulin resistance
mmiu04932  Non-alcoholic fatty liver disease
mmiu04933  AGE-RAGE signaling pathway in diabetic complications
mmiu04935  Growth hormone synthesis, secretion and action
mmiu04960  Aldosterone-regulated sodium reabsorption
mmiu04973  Carbohydrate digestion and absorption
mmiu05010  Alzheimer disease
mmiu05017  Spinocerebellar ataxia
mmiu05020  Prion disease
mmiu05100  Bacterial invasion of epithelial cells
mmiu05132  Salmonella infection
mmiu05135  Yersinia infection
mmiu05142  Chagas disease
mmiu05146  Amoebiasis
mmiu05160  Hepatitis C
mmiu05161  Hepatitis B
mmiu05162  Measles
mmiu05163  Human cytomegalovirus infection
mmiu05164  Influenza A
mmiu05165  Human papillomavirus infection
mmiu05166  Human T-cell leukemia virus 1 infection
mmiu05167  Kaposi sarcoma-associated herpesvirus infection
mmiu05168  Herpes simplex virus 1 infection
mmiu05169  Epstein-Barr virus infection
mmiu05170  Human immunodeficiency virus 1 infection
mmiu05171  Coronavirus disease
mmiu05200  Pathways in cancer
mmiu05203  Viral carcinogenesis
mmiu05205  Proteoglycans in cancer
mmiu05206  MicroRNAs in cancer
mmiu05207  Chemical carcinogenesis - receptor activation
mmiu05208  Chemical carcinogenesis - reactive oxygen species
mmiu05210  Colorectal cancer
mmiu05211  Renal cell carcinoma
mmiu05212  Pancreatic cancer
mmiu05213  Endometrial cancer
mmiu05214  Glioma
mmiu05215  Prostate cancer
mmiu05218  Melanoma
mmiu05220  Chronic myeloid leukemia
mmiu05221  Acute myeloid leukemia
mmiu05222  Small cell lung cancer
mmiu05223  Non-small cell lung cancer
mmiu05224  Breast cancer
mmiu05225  Hepatocellular carcinoma
mmiu05226  Gastric cancer
mmiu05230  Central carbon metabolism in cancer
mmiu05231  Choline metabolism in cancer
mmiu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmiu05415  Diabetic cardiomyopathy
mmiu05417  Lipid and atherosclerosis
mmiu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmiu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    308434570 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    308434570 (PIK3CB)
   04014 Ras signaling pathway
    308434570 (PIK3CB)
   04015 Rap1 signaling pathway
    308434570 (PIK3CB)
   04370 VEGF signaling pathway
    308434570 (PIK3CB)
   04630 JAK-STAT signaling pathway
    308434570 (PIK3CB)
   04668 TNF signaling pathway
    308434570 (PIK3CB)
   04066 HIF-1 signaling pathway
    308434570 (PIK3CB)
   04068 FoxO signaling pathway
    308434570 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    308434570 (PIK3CB)
   04072 Phospholipase D signaling pathway
    308434570 (PIK3CB)
   04071 Sphingolipid signaling pathway
    308434570 (PIK3CB)
   04024 cAMP signaling pathway
    308434570 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    308434570 (PIK3CB)
   04152 AMPK signaling pathway
    308434570 (PIK3CB)
   04150 mTOR signaling pathway
    308434570 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    308434570 (PIK3CB)
   04517 IgSF CAM signaling
    308434570 (PIK3CB)
   04518 Integrin signaling
    308434570 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    308434570 (PIK3CB)
   04140 Autophagy - animal
    308434570 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    308434570 (PIK3CB)
   04218 Cellular senescence
    308434570 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    308434570 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    308434570 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    308434570 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    308434570 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    308434570 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    308434570 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    308434570 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    308434570 (PIK3CB)
   04660 T cell receptor signaling pathway
    308434570 (PIK3CB)
   04662 B cell receptor signaling pathway
    308434570 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    308434570 (PIK3CB)
   04666 Fc gamma R-mediated phagosome formation
    308434570 (PIK3CB)
   04670 Leukocyte transendothelial migration
    308434570 (PIK3CB)
   04062 Chemokine signaling pathway
    308434570 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    308434570 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    308434570 (PIK3CB)
   04929 GnRH secretion
    308434570 (PIK3CB)
   04915 Estrogen signaling pathway
    308434570 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    308434570 (PIK3CB)
   04917 Prolactin signaling pathway
    308434570 (PIK3CB)
   04926 Relaxin signaling pathway
    308434570 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    308434570 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    308434570 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    308434570 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    308434570 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    308434570 (PIK3CB)
   04722 Neurotrophin signaling pathway
    308434570 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    308434570 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    308434570 (PIK3CB)
   04380 Osteoclast differentiation
    308434570 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    308434570 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    308434570 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308434570 (PIK3CB)
   05206 MicroRNAs in cancer
    308434570 (PIK3CB)
   05205 Proteoglycans in cancer
    308434570 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    308434570 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    308434570 (PIK3CB)
   05203 Viral carcinogenesis
    308434570 (PIK3CB)
   05230 Central carbon metabolism in cancer
    308434570 (PIK3CB)
   05231 Choline metabolism in cancer
    308434570 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308434570 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    308434570 (PIK3CB)
   05212 Pancreatic cancer
    308434570 (PIK3CB)
   05225 Hepatocellular carcinoma
    308434570 (PIK3CB)
   05226 Gastric cancer
    308434570 (PIK3CB)
   05214 Glioma
    308434570 (PIK3CB)
   05221 Acute myeloid leukemia
    308434570 (PIK3CB)
   05220 Chronic myeloid leukemia
    308434570 (PIK3CB)
   05218 Melanoma
    308434570 (PIK3CB)
   05211 Renal cell carcinoma
    308434570 (PIK3CB)
   05215 Prostate cancer
    308434570 (PIK3CB)
   05213 Endometrial cancer
    308434570 (PIK3CB)
   05224 Breast cancer
    308434570 (PIK3CB)
   05222 Small cell lung cancer
    308434570 (PIK3CB)
   05223 Non-small cell lung cancer
    308434570 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    308434570 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    308434570 (PIK3CB)
   05161 Hepatitis B
    308434570 (PIK3CB)
   05160 Hepatitis C
    308434570 (PIK3CB)
   05171 Coronavirus disease
    308434570 (PIK3CB)
   05164 Influenza A
    308434570 (PIK3CB)
   05162 Measles
    308434570 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    308434570 (PIK3CB)
   05163 Human cytomegalovirus infection
    308434570 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    308434570 (PIK3CB)
   05169 Epstein-Barr virus infection
    308434570 (PIK3CB)
   05165 Human papillomavirus infection
    308434570 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    308434570 (PIK3CB)
   05135 Yersinia infection
    308434570 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    308434570 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    308434570 (PIK3CB)
   05142 Chagas disease
    308434570 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308434570 (PIK3CB)
   05017 Spinocerebellar ataxia
    308434570 (PIK3CB)
   05020 Prion disease
    308434570 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308434570 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    308434570 (PIK3CB)
   05415 Diabetic cardiomyopathy
    308434570 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    308434570 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    308434570 (PIK3CB)
   04931 Insulin resistance
    308434570 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    308434570 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    308434570 (PIK3CB)
   01524 Platinum drug resistance
    308434570 (PIK3CB)
   01522 Endocrine resistance
    308434570 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmiu04131]
    308434570 (PIK3CB)
Enzymes [BR:mmiu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     308434570 (PIK3CB)
Membrane trafficking [BR:mmiu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    308434570 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 LepB_N DUF4381
Other DBs
NCBI-GeneID: 308434570
NCBI-ProteinID: XP_080791012
Position
21:complement(30548216..30646258)
AA seq 1070 aa
MCFHPIMPPAMADVLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDE
TSPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSSLPLPLPPKKTRVISHVWDNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYAENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALDNRRIGQFLFWHLRSEVHTPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYIEKCKYMD
SKMKPLWLVYSNRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttccaccctataatgcctcctgctatggcagacgtccttgacatctgggcagtg
gattcacagattgcgtctgatggctccatatctgtcgatttccttctgcccactgggatt
tatatccagttggaagtacctcgggaagctaccatttcttatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggacattgactcctatatgttt
gcatgtgtgaatcaaactgccgtatatgaggaacttgaagatgaaacacgaagactttgt
gacgtcagaccttttcttccagttctcaaattagtgactagaagctgtgacccagcagag
aaattggactcaaaaattggagttcttataggaaaaggtcttcatgaatttgatgccttg
aaggatcctgaagtgaatgaatttagaagaaaaatgcgcaaattcagtgaggacaagatc
cagtctctggtagggctgtcttggattgactggctgaagcacacgtatccacctgagcac
gagccgtccgtcctggagaacttggaagataaactttacggcgggaagctggttgtggct
gtgcattttgaaaatagccaggatgtgtttagttttcaagtgtctcccaatttaaatcct
ataaaaataaatgaattggcaatccagaaacgcctcactattcgtgggaaggaagatgaa
actagcccctgtgactacgtgttacaagtcagtgggagagtggagtatgtgtttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaataggaccctgccccat
ttcatccttgtggaatgttgtaagatcaagaaaatgtatgaacaagaaatgattgccata
gaggctgccatcaaccgaaactcgtccagccttcctctccctttaccaccaaagaaaaca
cgagttatctctcatgtctgggacaacaacaaccctttccaaattgtcttggtaaaagga
aataagcttaatacagaagaaaccgtgaaagttcatgtcagagccgggctttttcacggc
accgagctcctgtgcaaaaccgtcgtaagctcggagatatcaggaaagaatgaccatatt
tggaatgaacaactggaatttgatattaatatttgtgacttgccaagaatggctcgatta
tgttttgctatttatgcagttttggataaagtaaaaacgaagaaatcaacaaaaactatt
aatccctctaaatatcagaccatccggaaagctgggaaagtgcattatcctgtcgcgtgg
gtaaataccatggtttttgactttaaaggacagctgagatctggagacgtaatattgcac
agctggtcttcgtttcctgatgagctggaagaaatgctgaaccccatggggactgtgcag
acgaacccatatgctgagaatgcaaccgccttgcatattaagtttccagagaataagaag
cagccttattactacccccccttcgataagatcatcgagaaggcagctgagattgccagt
ggagacagtgctaacgtgtcaagtcgtggtgggaaaaaatttcttgctgtactgaaagaa
atcttggacagggaccccctgtctcaactgtgtgagaatgaaatggaccttatttggacc
ctacggcaagactgcagagaaaatttcccacagtcactgccaaaactactcctgtcaatc
aagtggaataaacttgaagatgttgctcagcttcaggcgctcctgcagatttggcccaaa
ctgccccccagggaagcactggagctcctggatttcaactatccagaccaatatgtccgg
gagtacgctgtaggctgccttcgacagatgagtgacgaagaactctctcagtatctttta
cagctggtgcaggttttgaaatacgagccttttcttgactgtgccctctccagattccta
ttagaaagagcacttgataatcggaggattgggcagtttctattttggcatcttaggtca
gaggtgcacactcctgctgtgtccgttcagtttggtgtcatcctggaggcatactgtcgg
gggagcgtagggcacatgaaagtgctttccaaacaggttgaagcactcaataagttaaaa
acgttaaatagtttaatcaaattgaatgcaatgaagctgaacagagctaaaggaaaggag
gccatgcacacgtgcttaaaacagagcgcttaccgggaggcgctctccgacctgcagtcg
cctctgaacccttgtgtcatcctctcagagctctatattgaaaagtgcaaatacatggac
tccaagatgaagcccctgtggctggtctacagcaacagagcctttggagaggactcggtg
ggagtgatctttaaaaatggcgatgatttgcggcaggacatgctgacgctgcagatgctg
cgcctgatggatctcctgtggaaagaagctggcttggaccttcggatgctcccctatggc
tgtttagcaacaggagatcgctctggcctcattgaggttgtgagcacctctgagacaatc
gctgacattcagctcaacagtagcaatgtggctgccacagcagccttcaacaaagacgcg
ctcctgaactggctaaaagagtacaattccggggatgacctggacagagcgattgaggag
ttcaccctgtcctgtgctggctactgtgtagcttcttatgtcctcggcattggtgacagg
cacagcgacaacatcatggtgaagaaaaccggccagcttttccacatagattttgggcat
attcttggaaatttcaaatctaaatttggcattaaaagagagcgagtaccttttattctt
acttatgacttcattcatgtcattcagcaaggaaaaacgggaaacacagaaaaatttggc
aggttccgccagtgctgcgaagatgcatacctgatcttacggcggcatgggaatctcttc
atcaccctgttcgcgctgatgctgactgcggggcttcctgagctcacatcagtcaaagac
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacaa
tttaagcagaagtttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gctcacacggttcggaaagactacaggtcttag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (11)   

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