KEGG   Marmota marmota marmota (Alpine marmot): 107139438
Entry
107139438         CDS       T09644                                 
Symbol
Pik3r1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mmma  Marmota marmota marmota (Alpine marmot)
Pathway
mmma01521  EGFR tyrosine kinase inhibitor resistance
mmma01522  Endocrine resistance
mmma01524  Platinum drug resistance
mmma04012  ErbB signaling pathway
mmma04014  Ras signaling pathway
mmma04015  Rap1 signaling pathway
mmma04024  cAMP signaling pathway
mmma04062  Chemokine signaling pathway
mmma04066  HIF-1 signaling pathway
mmma04068  FoxO signaling pathway
mmma04070  Phosphatidylinositol signaling system
mmma04071  Sphingolipid signaling pathway
mmma04072  Phospholipase D signaling pathway
mmma04081  Hormone signaling
mmma04140  Autophagy - animal
mmma04145  Phagocytosis
mmma04150  mTOR signaling pathway
mmma04151  PI3K-Akt signaling pathway
mmma04152  AMPK signaling pathway
mmma04210  Apoptosis
mmma04211  Longevity regulating pathway
mmma04213  Longevity regulating pathway - multiple species
mmma04218  Cellular senescence
mmma04360  Axon guidance
mmma04370  VEGF signaling pathway
mmma04380  Osteoclast differentiation
mmma04510  Focal adhesion
mmma04517  IgSF CAM signaling
mmma04518  Integrin signaling
mmma04550  Signaling pathways regulating pluripotency of stem cells
mmma04611  Platelet activation
mmma04613  Neutrophil extracellular trap formation
mmma04620  Toll-like receptor signaling pathway
mmma04625  C-type lectin receptor signaling pathway
mmma04630  JAK-STAT signaling pathway
mmma04650  Natural killer cell mediated cytotoxicity
mmma04660  T cell receptor signaling pathway
mmma04662  B cell receptor signaling pathway
mmma04664  Fc epsilon RI signaling pathway
mmma04666  Fc gamma R-mediated phagosome formation
mmma04668  TNF signaling pathway
mmma04670  Leukocyte transendothelial migration
mmma04722  Neurotrophin signaling pathway
mmma04725  Cholinergic synapse
mmma04750  Inflammatory mediator regulation of TRP channels
mmma04810  Regulation of actin cytoskeleton
mmma04910  Insulin signaling pathway
mmma04914  Progesterone-mediated oocyte maturation
mmma04915  Estrogen signaling pathway
mmma04917  Prolactin signaling pathway
mmma04919  Thyroid hormone signaling pathway
mmma04923  Regulation of lipolysis in adipocytes
mmma04926  Relaxin signaling pathway
mmma04929  GnRH secretion
mmma04930  Type II diabetes mellitus
mmma04931  Insulin resistance
mmma04932  Non-alcoholic fatty liver disease
mmma04933  AGE-RAGE signaling pathway in diabetic complications
mmma04935  Growth hormone synthesis, secretion and action
mmma04960  Aldosterone-regulated sodium reabsorption
mmma04973  Carbohydrate digestion and absorption
mmma05010  Alzheimer disease
mmma05017  Spinocerebellar ataxia
mmma05020  Prion disease
mmma05100  Bacterial invasion of epithelial cells
mmma05135  Yersinia infection
mmma05142  Chagas disease
mmma05146  Amoebiasis
mmma05160  Hepatitis C
mmma05161  Hepatitis B
mmma05162  Measles
mmma05163  Human cytomegalovirus infection
mmma05164  Influenza A
mmma05165  Human papillomavirus infection
mmma05166  Human T-cell leukemia virus 1 infection
mmma05167  Kaposi sarcoma-associated herpesvirus infection
mmma05168  Herpes simplex virus 1 infection
mmma05169  Epstein-Barr virus infection
mmma05170  Human immunodeficiency virus 1 infection
mmma05171  Coronavirus disease
mmma05200  Pathways in cancer
mmma05203  Viral carcinogenesis
mmma05205  Proteoglycans in cancer
mmma05206  MicroRNAs in cancer
mmma05207  Chemical carcinogenesis - receptor activation
mmma05208  Chemical carcinogenesis - reactive oxygen species
mmma05210  Colorectal cancer
mmma05211  Renal cell carcinoma
mmma05212  Pancreatic cancer
mmma05213  Endometrial cancer
mmma05214  Glioma
mmma05215  Prostate cancer
mmma05218  Melanoma
mmma05220  Chronic myeloid leukemia
mmma05221  Acute myeloid leukemia
mmma05222  Small cell lung cancer
mmma05223  Non-small cell lung cancer
mmma05224  Breast cancer
mmma05225  Hepatocellular carcinoma
mmma05226  Gastric cancer
mmma05230  Central carbon metabolism in cancer
mmma05231  Choline metabolism in cancer
mmma05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmma05415  Diabetic cardiomyopathy
mmma05417  Lipid and atherosclerosis
mmma05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmma00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    107139438 (Pik3r1)
   04014 Ras signaling pathway
    107139438 (Pik3r1)
   04015 Rap1 signaling pathway
    107139438 (Pik3r1)
   04370 VEGF signaling pathway
    107139438 (Pik3r1)
   04630 JAK-STAT signaling pathway
    107139438 (Pik3r1)
   04668 TNF signaling pathway
    107139438 (Pik3r1)
   04066 HIF-1 signaling pathway
    107139438 (Pik3r1)
   04068 FoxO signaling pathway
    107139438 (Pik3r1)
   04070 Phosphatidylinositol signaling system
    107139438 (Pik3r1)
   04072 Phospholipase D signaling pathway
    107139438 (Pik3r1)
   04071 Sphingolipid signaling pathway
    107139438 (Pik3r1)
   04024 cAMP signaling pathway
    107139438 (Pik3r1)
   04151 PI3K-Akt signaling pathway
    107139438 (Pik3r1)
   04152 AMPK signaling pathway
    107139438 (Pik3r1)
   04150 mTOR signaling pathway
    107139438 (Pik3r1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    107139438 (Pik3r1)
   04517 IgSF CAM signaling
    107139438 (Pik3r1)
   04518 Integrin signaling
    107139438 (Pik3r1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    107139438 (Pik3r1)
   04140 Autophagy - animal
    107139438 (Pik3r1)
  09143 Cell growth and death
   04210 Apoptosis
    107139438 (Pik3r1)
   04218 Cellular senescence
    107139438 (Pik3r1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107139438 (Pik3r1)
   04550 Signaling pathways regulating pluripotency of stem cells
    107139438 (Pik3r1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107139438 (Pik3r1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    107139438 (Pik3r1)
   04613 Neutrophil extracellular trap formation
    107139438 (Pik3r1)
   04620 Toll-like receptor signaling pathway
    107139438 (Pik3r1)
   04625 C-type lectin receptor signaling pathway
    107139438 (Pik3r1)
   04650 Natural killer cell mediated cytotoxicity
    107139438 (Pik3r1)
   04660 T cell receptor signaling pathway
    107139438 (Pik3r1)
   04662 B cell receptor signaling pathway
    107139438 (Pik3r1)
   04664 Fc epsilon RI signaling pathway
    107139438 (Pik3r1)
   04666 Fc gamma R-mediated phagosome formation
    107139438 (Pik3r1)
   04670 Leukocyte transendothelial migration
    107139438 (Pik3r1)
   04062 Chemokine signaling pathway
    107139438 (Pik3r1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107139438 (Pik3r1)
   04923 Regulation of lipolysis in adipocytes
    107139438 (Pik3r1)
   04929 GnRH secretion
    107139438 (Pik3r1)
   04915 Estrogen signaling pathway
    107139438 (Pik3r1)
   04914 Progesterone-mediated oocyte maturation
    107139438 (Pik3r1)
   04917 Prolactin signaling pathway
    107139438 (Pik3r1)
   04926 Relaxin signaling pathway
    107139438 (Pik3r1)
   04935 Growth hormone synthesis, secretion and action
    107139438 (Pik3r1)
   04919 Thyroid hormone signaling pathway
    107139438 (Pik3r1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    107139438 (Pik3r1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    107139438 (Pik3r1)
  09156 Nervous system
   04725 Cholinergic synapse
    107139438 (Pik3r1)
   04722 Neurotrophin signaling pathway
    107139438 (Pik3r1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    107139438 (Pik3r1)
  09158 Development and regeneration
   04360 Axon guidance
    107139438 (Pik3r1)
   04380 Osteoclast differentiation
    107139438 (Pik3r1)
  09149 Aging
   04211 Longevity regulating pathway
    107139438 (Pik3r1)
   04213 Longevity regulating pathway - multiple species
    107139438 (Pik3r1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107139438 (Pik3r1)
   05206 MicroRNAs in cancer
    107139438 (Pik3r1)
   05205 Proteoglycans in cancer
    107139438 (Pik3r1)
   05207 Chemical carcinogenesis - receptor activation
    107139438 (Pik3r1)
   05208 Chemical carcinogenesis - reactive oxygen species
    107139438 (Pik3r1)
   05203 Viral carcinogenesis
    107139438 (Pik3r1)
   05230 Central carbon metabolism in cancer
    107139438 (Pik3r1)
   05231 Choline metabolism in cancer
    107139438 (Pik3r1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107139438 (Pik3r1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107139438 (Pik3r1)
   05212 Pancreatic cancer
    107139438 (Pik3r1)
   05225 Hepatocellular carcinoma
    107139438 (Pik3r1)
   05226 Gastric cancer
    107139438 (Pik3r1)
   05214 Glioma
    107139438 (Pik3r1)
   05221 Acute myeloid leukemia
    107139438 (Pik3r1)
   05220 Chronic myeloid leukemia
    107139438 (Pik3r1)
   05218 Melanoma
    107139438 (Pik3r1)
   05211 Renal cell carcinoma
    107139438 (Pik3r1)
   05215 Prostate cancer
    107139438 (Pik3r1)
   05213 Endometrial cancer
    107139438 (Pik3r1)
   05224 Breast cancer
    107139438 (Pik3r1)
   05222 Small cell lung cancer
    107139438 (Pik3r1)
   05223 Non-small cell lung cancer
    107139438 (Pik3r1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    107139438 (Pik3r1)
   05170 Human immunodeficiency virus 1 infection
    107139438 (Pik3r1)
   05161 Hepatitis B
    107139438 (Pik3r1)
   05160 Hepatitis C
    107139438 (Pik3r1)
   05171 Coronavirus disease
    107139438 (Pik3r1)
   05164 Influenza A
    107139438 (Pik3r1)
   05162 Measles
    107139438 (Pik3r1)
   05168 Herpes simplex virus 1 infection
    107139438 (Pik3r1)
   05163 Human cytomegalovirus infection
    107139438 (Pik3r1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    107139438 (Pik3r1)
   05169 Epstein-Barr virus infection
    107139438 (Pik3r1)
   05165 Human papillomavirus infection
    107139438 (Pik3r1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    107139438 (Pik3r1)
   05100 Bacterial invasion of epithelial cells
    107139438 (Pik3r1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    107139438 (Pik3r1)
   05142 Chagas disease
    107139438 (Pik3r1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107139438 (Pik3r1)
   05017 Spinocerebellar ataxia
    107139438 (Pik3r1)
   05020 Prion disease
    107139438 (Pik3r1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107139438 (Pik3r1)
   05418 Fluid shear stress and atherosclerosis
    107139438 (Pik3r1)
   05415 Diabetic cardiomyopathy
    107139438 (Pik3r1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    107139438 (Pik3r1)
   04932 Non-alcoholic fatty liver disease
    107139438 (Pik3r1)
   04931 Insulin resistance
    107139438 (Pik3r1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    107139438 (Pik3r1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107139438 (Pik3r1)
   01524 Platinum drug resistance
    107139438 (Pik3r1)
   01522 Endocrine resistance
    107139438 (Pik3r1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmma04131]
    107139438 (Pik3r1)
Membrane trafficking [BR:mmma04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    107139438 (Pik3r1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 CEP135_TSGA10_CC Laminin_I ODF2_C PI_PP_I DicA_C Imm6 Exonuc_VII_L DUF2203 Bap31_Bap29_C Transcrip_act
Other DBs
NCBI-GeneID: 107139438
NCBI-ProteinID: XP_015337771
Ensembl: ENSMMMG00000000130
UniProt: A0A8C5YI24
Position
Unknown
AA seq 454 aa
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTAANNSMNNNISLQD
AEWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY
GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE
KFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL
IQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSN
RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSS
LKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgtacaacactgtttggaatatggaagacctggatttagaatatgccaagacagatata
aactgtggcacagacttgatgttttatatagaaatggatccaccagcactgcctcctaaa
ccgcccaaacccaccactgcagccaacaacagtatgaacaacaatatttccttacaggat
gctgaatggtactggggagagatctcgagggaagaagtgaatgaaaaacttcgagataca
gcagatggaacctttttggtacgagatgcctctactaaaatgcacggcgattatactctt
acactaaggaaaggaggaaataacaaattaatcaaaatatttcaccgagatggaaaatat
ggcttctctgacccattaaccttcaattctgtggttgaactaataaaccactaccggaat
gaatctctagctcagtacaatcccaaactggatgtgaaattactttatccagtatccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtggggaaaaaattacat
gaatataacactcaatttcaagaaaaaagccgggaatatgatagattatatgaagaatat
acccgtacttcccaggaaatacaaatgaaaagaacagctattgaagcatttaatgaaacc
ataaaaatatttgaagaacagtgccaaacccaggaacggtacagcaaagaatacatagaa
aagtttaaacgtgaaggcaatgaaaaagaaatacagaggattatgcataattatgataag
ctaaagtctcgaatcagtgaaattattgacagtagaagaaggctggaggaagacttgaag
aagcaggcagctgagtatcgtgagattgacaaacgtatgaacagcattaagccagacctc
attcaactgagaaagaccagggaccagtacttgatgtggctgactcaaaaaggtgtccgg
caaaagaagctaaatgagtggctaggcaacgaaaatactgaagaccaatattctctggtg
gaagacgatgaggatttaccccaccatgatgagaagacatggaatgttggaagcagcaac
cgaaacaaagctgaaaacctattgcgagggaaacgagatggcacttttcttgtccgggag
agcagtaagcaaggctgctacgcctgctccgtagtggtggacggtgaagtcaagcattgt
gtcatcaacaaaacggcgactggctacggctttgcggagccttataacctgtacagctcc
ctgaaggaactggtgctacattaccaacacacctcccttgtgcagcacaacgactccctc
aacgtcacactagcatacccggtatatgcacagcagaggcgatga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (13)   
   Pfam (13)   
All databases (23)   

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