KEGG   PATHWAY: mmu04622
Entry
mmu04622                    Pathway                                

Name
RIG-I-like receptor signaling pathway - Mus musculus (mouse)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
mmu04622  RIG-I-like receptor signaling pathway
mmu04622

Organism
Mus musculus (mouse) [GN:mmu]
Gene
230073  Ddx58; DEAD/H box helicase 58 [KO:K12646] [EC:3.6.4.13]
71586  Ifih1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
228607  Mavs; mitochondrial antiviral signaling protein [KO:K12648]
80861  Dhx58; DEXH (Asp-Glu-X-His) box polypeptide 58 [KO:K12649] [EC:3.6.4.13]
22031  Traf3; TNF receptor-associated factor 3 [KO:K03174]
21353  Tank; TRAF family member-associated Nf-kappa B activator [KO:K12650]
27215  Azi2; 5-azacytidine induced gene 2 [KO:K12651]
73174  Tbkbp1; TBK1 binding protein 1 [KO:K12652]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
56480  Tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
56489  Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
54123  Irf7; interferon regulatory factor 7 [KO:K09447]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
230396  Ifna13; interferon alpha 13 [KO:K05414]
404549  Ifna14; interferon alpha 14 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
242517  Ifna15; interferon alpha 15 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
15977  Ifnb1; interferon beta 1, fibroblast [KO:K05415]
230405  Ifne; interferon epsilon [KO:K05442]
387510  Ifnk; interferon kappa [KO:K05441]
71609  Tradd; TNFRSF1A-associated via death domain [KO:K03171]
14082  Fadd; Fas (TNFRSF6)-associated via death domain [KO:K02373]
19766  Ripk1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
18036  Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
26409  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
22034  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
26401  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
21926  Tnf; tumor necrosis factor [KO:K03156]
16159  Il12a; interleukin 12a [KO:K05406]
16160  Il12b; interleukin 12b [KO:K05425]
15945  Cxcl10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
217069  Trim25; tripartite motif-containing 25 [KO:K10652] [EC:2.3.2.27]
74256  Cyld; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
67664  Rnf125; ring finger protein 125 [KO:K12170] [EC:2.3.2.27]
100038882  Isg15; ISG15 ubiquitin-like modifier [KO:K12159]
11793  Atg5; autophagy related 5 [KO:K08339]
67526  Atg12; autophagy related 12 [KO:K08336]
270151  Nlrx1; NLR family member X1 [KO:K12653]
72512  Sting1; stimulator of interferon response cGAMP interactor 1 [KO:K12654]
54644  Otud5; OTU domain containing 5 [KO:K12655] [EC:3.4.19.12]
66641  Sike1; suppressor of IKBKE 1 [KO:K12656]
13205  Ddx3x; DEAD box helicase 3, X-linked [KO:K11594] [EC:3.6.4.13]
110957  D1Pas1; DNA segment, Chr 1, Pasteur Institute 1 [KO:K11594] [EC:3.6.4.13]
23988  Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
241593  Pin1rt1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 [KO:K09578] [EC:5.2.1.8]
225913  Tkfc; triokinase, FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Related
pathway
mmu04010  MAPK signaling pathway
mmu04120  Ubiquitin mediated proteolysis
mmu04210  Apoptosis
mmu04630  JAK-STAT signaling pathway
KO pathway
ko04622   

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