KEGG   Mus musculus (mouse): 18746
Entry
18746             CDS       T01002                                 

Gene name
Pkm, AA414905, AL024370, AL024424, Pk, Pk-, Pk-2, Pk-3, Pk3, Pkm2
Definition
(RefSeq) pyruvate kinase, muscle
  KO
K00873  pyruvate kinase [EC:2.7.1.40]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00230  Purine metabolism
mmu00620  Pyruvate metabolism
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu01230  Biosynthesis of amino acids
mmu01240  Biosynthesis of cofactors
mmu04922  Glucagon signaling pathway
mmu04930  Type II diabetes mellitus
mmu05165  Human papillomavirus infection
mmu05203  Viral carcinogenesis
mmu05230  Central carbon metabolism in cancer
Module
mmu_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
mmu_M00002  Glycolysis, core module involving three-carbon compounds
mmu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
mmu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    18746 (Pkm)
   00620 Pyruvate metabolism
    18746 (Pkm)
  09104 Nucleotide metabolism
   00230 Purine metabolism
    18746 (Pkm)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    18746 (Pkm)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    18746 (Pkm)
   05230 Central carbon metabolism in cancer
    18746 (Pkm)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    18746 (Pkm)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    18746 (Pkm)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    18746 (Pkm)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    18746 (Pkm)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     18746 (Pkm)
Membrane trafficking [BR:mmu04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    18746 (Pkm)
Exosome [BR:mmu04147]
 Exosomal proteins
  Proteins found in most exosomes
   18746 (Pkm)
SSDB
Motif
Pfam: PK PK_C HpcH_HpaI IMPDH
Other DBs
NCBI-GeneID: 18746
NCBI-ProteinID: NP_001240812
MGI: 97591
Ensembl: ENSMUSG00000032294
Vega: OTTMUSG00000063298
UniProt: P52480
Position
9 B; 9 32.03 cM
AA seq 531 aa
MPKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEM
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAMFHRLLFEELVRASSHSTDLMEAMAMGSVEAS
YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLN
AWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
NT seq 1596 nt   +upstreamnt  +downstreamnt
atgccgaagccacacagtgaagcagggactgccttcattcagacccagcagctccatgca
gccatggctgacaccttcctggaacacatgtgccgcctggacattgactctgcccccatc
acggcccgcaacactggcatcatttgtaccattgggcctgcttcccgatctgtggagatg
ctgaaggagatgattaagtctggaatgaatgtggctcggctgaatttctctcatggaacc
catgagtaccatgcagagaccatcaagaatgtccgtgaagccacagaaagctttgcatct
gatcccattctctaccgtcctgttgcggtggctctggatacaaagggacctgagatccgg
actggactcatcaagggcagcggcaccgctgaggtggagctgaagaagggagccactctg
aagatcaccctggacaacgcttacatggagaagtgtgacgagaacatcctgtggctggac
tacaagaacatctgcaaggtggtggaggtgggcagcaagatctacgtggacgatgggctc
atctcactgcaggtgaaggagaaaggcgctgacttcctggtgacggaggtggagaatggt
ggctccttgggcagcaagaagggcgtgaacctgccgggcgctgctgtggatctccccgct
gtgtcggaaaaggacatccaggacctgaagtttggggtggagcaggatgtggacatggtg
tttgcatctttcatccgcaaggcagccgacgtgcatgaagtcaggaaggtgctgggagag
aagggcaagaacatcaagatcatcagcaaaatcgagaaccatgaaggcgtccgcaggttt
gatgagatcttggaggccagtgatgggatcatggtggctcgtggtgacctgggcattgag
attcctgcagagaaggtcttcctggctcagaagatgatgatcgggcgatgcaaccgagct
gggaagcctgtcatctgtgccacacagatgctggagagcatgatcaagaagccacgcccc
acccgtgctgaaggcagtgatgtggccaatgcagtcctggatggagcagactgcatcatg
ctgtctggagaaacagccaagggggactaccctctggaggctgttcgcatgcagcacctg
atagctcgggaggctgaggcagccatgttccaccgtctgctgtttgaagagcttgtgcga
gcctccagtcactccacagacctcatggaggccatggccatgggcagcgtggaggcctct
tataagtgtttagcagcagctttgatagttctcacggagtctggcaggagtgctcaccaa
gtggccaggtaccgccctcgggctcctatcattgccgtgactcgaaatccccagactgct
cgccaggcccatctgtaccgtggcatcttccctgtgctgtgtaaggatgccgtgctgaat
gcctgggctgaggatgtcgaccttcgtgtaaacttggccatggatgttggcaaggcccga
ggcttcttcaagaagggagatgtggtcattgtgctgaccgggtggcgccctggctctgga
ttcaccaacaccatgcgtgtagtgcctgtaccttga

KEGG   Mus musculus (mouse): 18770
Entry
18770             CDS       T01002                                 

Gene name
Pklr, Pk, Pk-, Pk-1, Pk1, R-, R-PK
Definition
(RefSeq) pyruvate kinase liver and red blood cell
  KO
K12406  pyruvate kinase isozymes R/L [EC:2.7.1.40]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00230  Purine metabolism
mmu00620  Pyruvate metabolism
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu01230  Biosynthesis of amino acids
mmu01240  Biosynthesis of cofactors
mmu04910  Insulin signaling pathway
mmu04930  Type II diabetes mellitus
mmu04932  Non-alcoholic fatty liver disease
mmu04950  Maturity onset diabetes of the young
Module
mmu_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
mmu_M00002  Glycolysis, core module involving three-carbon compounds
mmu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
mmu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    18770 (Pklr)
   00620 Pyruvate metabolism
    18770 (Pklr)
  09104 Nucleotide metabolism
   00230 Purine metabolism
    18770 (Pklr)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    18770 (Pklr)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    18770 (Pklr)
   04950 Maturity onset diabetes of the young
    18770 (Pklr)
   04932 Non-alcoholic fatty liver disease
    18770 (Pklr)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    18770 (Pklr)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     18770 (Pklr)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   18770 (Pklr)
SSDB
Motif
Pfam: PK PK_C IMPDH
Other DBs
NCBI-GeneID: 18770
NCBI-ProteinID: NP_001093249
MGI: 97604
Ensembl: ENSMUSG00000041237
Vega: OTTMUSG00000017504
UniProt: E9Q509 Q3UEI4 Q3UEH4
Position
3 F1; 3 39.01 cM
AA seq 543 aa
MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSII
ATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPV
AIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVV
AVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLD
LRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSD
GIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV
ANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP
TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRG
VFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL
TIS
NT seq 1632 nt   +upstreamnt  +downstreamnt
atggaagggccagcaggatacctgagacgtgccagtgtggcccagctgacccaggagctg
ggcactgccttcttccagcagcagcaactgcccgcagctatggcggacaccttcctggaa
cacctctgccttctggatatcgactcagagcctgtggccgctaggagcaccagcatcatt
gccaccatcgggccggcgtcacgctctgtggaccgcctcaaggagatgatcaaggcaggg
atgaacattgcacgactcaacttctcccatggctcccatgagtaccatgcagagtccatc
gccaacattcgggaggcggctgaaagctttgcaacctccccactcagctacagacccgtg
gccatcgccctggacaccaagggtcccgagatacgcactggagtcctgcaggggggtcca
gagtcggaggtggaaattgtgaagggttcacaggtgctggtgactgtggatccgaagttc
cggacaaggggcgatgcaaagacagtgtgggtggactaccacaatatcacccaggtcgtt
gcagtggggggccgcatctacattgacgacgggctcatctccttagtggtgcggaaaatt
ggcccagagggactggtgaccgaagtggaacacggtggtttcttgggcaacaggaagggt
gtgaacttgccaaatgccgaggtggacctgcctgggctatcagagcaagatcttttggat
ctgcgcttcggggtggagcataatgtggacatcatctttgcctcctttgtacgaaaagcc
agtgatgtggtggcagtccgagatgccctagggccagaaggacggggcatcaaaattatc
agcaaaatcgagaaccatgaaggcgtgaagaagtttgatgagatcctagaagtgagcgat
ggcatcatggtggctcggggtgaccttggcattgagatcccagcagagaaggttttcttg
gctcagaagatgatgattggacgctgcaacctggctggcaagcctgtcgtttgtgccaca
cagatgctggagagcatgatcactaaggctcgaccaactcgggcggagacaagcgatgtg
gccaatgctgtgctggatggggctgactgtatcatgctgtctggagagaccgccaaaggc
agtttccccgtggaggctgtaaagatgcaacatgcgattgcccgggaggcagaggccgct
gtgtaccaccgccagttgtttgaggagctacgccgggcagcgccgctgagccgtgaccca
accgaggtcactgcaattggagccgtggaggcttccttcaagtgctgtgccgcagccatc
attgtgctgacaaagactggccgctcagctcagcttctgtctcgctaccgacctcgggct
gctgtcattgctgtgactcgttctgcccaggctgcccgacaggtccacctgtcccgagga
gtcttccccttgctctaccgtgagcctccagaggctgtctgggcagatgatgtggaccga
agggtccaatttggcatcgaaagtggaaagcttcgtggcttcctccgagttggtgatctg
gtgattgtggtgacaggctggcgacctggctctggctataccaacattatgcgggtgctg
accatatcctga

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