KEGG   Mustela nigripes (black-footed ferret): 132021734
Entry
132021734         CDS       T09425                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp00562  Inositol phosphate metabolism
mnp01100  Metabolic pathways
mnp04015  Rap1 signaling pathway
mnp04020  Calcium signaling pathway
mnp04022  cGMP-PKG signaling pathway
mnp04062  Chemokine signaling pathway
mnp04070  Phosphatidylinositol signaling system
mnp04071  Sphingolipid signaling pathway
mnp04072  Phospholipase D signaling pathway
mnp04081  Hormone signaling
mnp04082  Neuroactive ligand signaling
mnp04261  Adrenergic signaling in cardiomyocytes
mnp04270  Vascular smooth muscle contraction
mnp04310  Wnt signaling pathway
mnp04371  Apelin signaling pathway
mnp04540  Gap junction
mnp04611  Platelet activation
mnp04613  Neutrophil extracellular trap formation
mnp04621  NOD-like receptor signaling pathway
mnp04713  Circadian entrainment
mnp04720  Long-term potentiation
mnp04723  Retrograde endocannabinoid signaling
mnp04724  Glutamatergic synapse
mnp04725  Cholinergic synapse
mnp04726  Serotonergic synapse
mnp04728  Dopaminergic synapse
mnp04730  Long-term depression
mnp04742  Taste transduction
mnp04750  Inflammatory mediator regulation of TRP channels
mnp04911  Insulin secretion
mnp04912  GnRH signaling pathway
mnp04915  Estrogen signaling pathway
mnp04916  Melanogenesis
mnp04918  Thyroid hormone synthesis
mnp04919  Thyroid hormone signaling pathway
mnp04921  Oxytocin signaling pathway
mnp04922  Glucagon signaling pathway
mnp04924  Renin secretion
mnp04925  Aldosterone synthesis and secretion
mnp04926  Relaxin signaling pathway
mnp04927  Cortisol synthesis and secretion
mnp04928  Parathyroid hormone synthesis, secretion and action
mnp04929  GnRH secretion
mnp04933  AGE-RAGE signaling pathway in diabetic complications
mnp04934  Cushing syndrome
mnp04935  Growth hormone synthesis, secretion and action
mnp04961  Endocrine and other factor-regulated calcium reabsorption
mnp04970  Salivary secretion
mnp04971  Gastric acid secretion
mnp04972  Pancreatic secretion
mnp04973  Carbohydrate digestion and absorption
mnp05010  Alzheimer disease
mnp05016  Huntington disease
mnp05017  Spinocerebellar ataxia
mnp05022  Pathways of neurodegeneration - multiple diseases
mnp05142  Chagas disease
mnp05143  African trypanosomiasis
mnp05146  Amoebiasis
mnp05163  Human cytomegalovirus infection
mnp05200  Pathways in cancer
mnp05415  Diabetic cardiomyopathy
mnp05417  Lipid and atherosclerosis
Module
mnp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    132021734 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    132021734 (PLCB1)
   04310 Wnt signaling pathway
    132021734 (PLCB1)
   04371 Apelin signaling pathway
    132021734 (PLCB1)
   04020 Calcium signaling pathway
    132021734 (PLCB1)
   04070 Phosphatidylinositol signaling system
    132021734 (PLCB1)
   04072 Phospholipase D signaling pathway
    132021734 (PLCB1)
   04071 Sphingolipid signaling pathway
    132021734 (PLCB1)
   04022 cGMP-PKG signaling pathway
    132021734 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    132021734 (PLCB1)
   04081 Hormone signaling
    132021734 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    132021734 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132021734 (PLCB1)
   04613 Neutrophil extracellular trap formation
    132021734 (PLCB1)
   04621 NOD-like receptor signaling pathway
    132021734 (PLCB1)
   04062 Chemokine signaling pathway
    132021734 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    132021734 (PLCB1)
   04922 Glucagon signaling pathway
    132021734 (PLCB1)
   04929 GnRH secretion
    132021734 (PLCB1)
   04912 GnRH signaling pathway
    132021734 (PLCB1)
   04915 Estrogen signaling pathway
    132021734 (PLCB1)
   04921 Oxytocin signaling pathway
    132021734 (PLCB1)
   04926 Relaxin signaling pathway
    132021734 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    132021734 (PLCB1)
   04918 Thyroid hormone synthesis
    132021734 (PLCB1)
   04919 Thyroid hormone signaling pathway
    132021734 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    132021734 (PLCB1)
   04916 Melanogenesis
    132021734 (PLCB1)
   04924 Renin secretion
    132021734 (PLCB1)
   04925 Aldosterone synthesis and secretion
    132021734 (PLCB1)
   04927 Cortisol synthesis and secretion
    132021734 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    132021734 (PLCB1)
   04270 Vascular smooth muscle contraction
    132021734 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    132021734 (PLCB1)
   04971 Gastric acid secretion
    132021734 (PLCB1)
   04972 Pancreatic secretion
    132021734 (PLCB1)
   04973 Carbohydrate digestion and absorption
    132021734 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    132021734 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    132021734 (PLCB1)
   04725 Cholinergic synapse
    132021734 (PLCB1)
   04728 Dopaminergic synapse
    132021734 (PLCB1)
   04726 Serotonergic synapse
    132021734 (PLCB1)
   04720 Long-term potentiation
    132021734 (PLCB1)
   04730 Long-term depression
    132021734 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    132021734 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    132021734 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    132021734 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    132021734 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132021734 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    132021734 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132021734 (PLCB1)
   05142 Chagas disease
    132021734 (PLCB1)
   05143 African trypanosomiasis
    132021734 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132021734 (PLCB1)
   05016 Huntington disease
    132021734 (PLCB1)
   05017 Spinocerebellar ataxia
    132021734 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    132021734 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132021734 (PLCB1)
   05415 Diabetic cardiomyopathy
    132021734 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    132021734 (PLCB1)
   04934 Cushing syndrome
    132021734 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mnp04131]
    132021734 (PLCB1)
Enzymes [BR:mnp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     132021734 (PLCB1)
Membrane trafficking [BR:mnp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    132021734 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    132021734 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 132021734
NCBI-ProteinID: XP_059262537
Position
7:complement(106447966..107127844)
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPVKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHRPPSS
DELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggaccgatcaaaacaaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcatgccaaagct
cccaaggaccccaagttacgtgaacttttggatgtggggaacatcgggcgcctggagcat
cgtatgataaccgtggtgtatgggcctgacttggttaacatctcccatttgaatctcgtg
gctttccaagaagaagtagccaaggagtggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaatatgtcaagagacgcatttctggaaaaagcctatactaagcttaaa
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaaacgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtatacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
actgttgatcagatgatggactttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaaccc
aacaatagtctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcaa
cccctctctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgtcgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccacgggttt
accatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacataagtcgtcggaaggaagtggcaaaaag
aagctctcagaacaagcctccaacacgtacagtgactcctccagcatgttcgagccctcg
tctcccggagccggggaagcggacactgagagtgacgacgacgacgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgccgggagcgaggccatggccactgaagagatg
tctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggccttgagcaactgacg
aagtctcccgtggaatttgtagaatataacaaaatgcagcttagcaggatatatccgaaa
ggaacccgtgtggattcatcgaactacatgcctcagctcttctggaatgcaggttgccaa
atggttgcccttaattttcaaactgtggacctcgctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaaaccagagttcatgaggagacctgacaag
cattttgatcccttcaccgaaggcatcgtggatgggatagtggccaacactttatctgtc
aagattatttcaggtcagtttctttccgataagaaagtcgggacttacgtagaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcccgtctgggaagaagagcccattgtgttcaaaaaggtggtccttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaattcattggtcaccgg
atcttgccagtacaagcaattcggccaggctatcactacatctgcctgaggaatgaaagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctcatg
gagcaaagagctaaacagttagctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccttggcacccaaaccaccatcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgtgaaaacagaagaccttattcagagt
gtcctaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcctttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accactgaccttatcaaagaacacactacaaaatataatgagattcagaatgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagacccc
agcagtcctgaccatggttcatcaacgattgaacaagatcttgctgccctagatgctgaa
atgacccaaaagttaatagacttgaaagacaaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaatatcagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaataatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggagttaaagaagaagatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccga
tcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcaacagatcctggacgaaaagccc
aagctgcagacagacctggagcaagaataccaagacaagttcaaaagactgcccctggag
atcttggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagcaaccacagc
tctgcccctccctccctggcctcagagcctggaaaaatgaaccacaggcctccctccagt
gacgagctggaaggagacaacccaggaaaagagttcgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (6)   
   Pfam (6)   
All databases (14)   

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