KEGG   Muntiacus reevesi (Reeves' muntjac): 136159067
Entry
136159067         CDS       T10466                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mree  Muntiacus reevesi (Reeves' muntjac)
Pathway
mree00562  Inositol phosphate metabolism
mree01100  Metabolic pathways
mree04015  Rap1 signaling pathway
mree04020  Calcium signaling pathway
mree04022  cGMP-PKG signaling pathway
mree04062  Chemokine signaling pathway
mree04070  Phosphatidylinositol signaling system
mree04071  Sphingolipid signaling pathway
mree04072  Phospholipase D signaling pathway
mree04081  Hormone signaling
mree04082  Neuroactive ligand signaling
mree04261  Adrenergic signaling in cardiomyocytes
mree04270  Vascular smooth muscle contraction
mree04310  Wnt signaling pathway
mree04371  Apelin signaling pathway
mree04540  Gap junction
mree04611  Platelet activation
mree04613  Neutrophil extracellular trap formation
mree04621  NOD-like receptor signaling pathway
mree04713  Circadian entrainment
mree04720  Long-term potentiation
mree04723  Retrograde endocannabinoid signaling
mree04724  Glutamatergic synapse
mree04725  Cholinergic synapse
mree04726  Serotonergic synapse
mree04728  Dopaminergic synapse
mree04730  Long-term depression
mree04742  Taste transduction
mree04750  Inflammatory mediator regulation of TRP channels
mree04911  Insulin secretion
mree04912  GnRH signaling pathway
mree04915  Estrogen signaling pathway
mree04916  Melanogenesis
mree04918  Thyroid hormone synthesis
mree04919  Thyroid hormone signaling pathway
mree04921  Oxytocin signaling pathway
mree04922  Glucagon signaling pathway
mree04924  Renin secretion
mree04925  Aldosterone synthesis and secretion
mree04926  Relaxin signaling pathway
mree04927  Cortisol synthesis and secretion
mree04928  Parathyroid hormone synthesis, secretion and action
mree04929  GnRH secretion
mree04933  AGE-RAGE signaling pathway in diabetic complications
mree04934  Cushing syndrome
mree04935  Growth hormone synthesis, secretion and action
mree04961  Endocrine and other factor-regulated calcium reabsorption
mree04970  Salivary secretion
mree04971  Gastric acid secretion
mree04972  Pancreatic secretion
mree04973  Carbohydrate digestion and absorption
mree05010  Alzheimer disease
mree05016  Huntington disease
mree05017  Spinocerebellar ataxia
mree05022  Pathways of neurodegeneration - multiple diseases
mree05142  Chagas disease
mree05143  African trypanosomiasis
mree05146  Amoebiasis
mree05163  Human cytomegalovirus infection
mree05200  Pathways in cancer
mree05415  Diabetic cardiomyopathy
mree05417  Lipid and atherosclerosis
Module
mree_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mree00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    136159067 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    136159067 (PLCB4)
   04310 Wnt signaling pathway
    136159067 (PLCB4)
   04371 Apelin signaling pathway
    136159067 (PLCB4)
   04020 Calcium signaling pathway
    136159067 (PLCB4)
   04070 Phosphatidylinositol signaling system
    136159067 (PLCB4)
   04072 Phospholipase D signaling pathway
    136159067 (PLCB4)
   04071 Sphingolipid signaling pathway
    136159067 (PLCB4)
   04022 cGMP-PKG signaling pathway
    136159067 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    136159067 (PLCB4)
   04081 Hormone signaling
    136159067 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    136159067 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    136159067 (PLCB4)
   04613 Neutrophil extracellular trap formation
    136159067 (PLCB4)
   04621 NOD-like receptor signaling pathway
    136159067 (PLCB4)
   04062 Chemokine signaling pathway
    136159067 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    136159067 (PLCB4)
   04922 Glucagon signaling pathway
    136159067 (PLCB4)
   04929 GnRH secretion
    136159067 (PLCB4)
   04912 GnRH signaling pathway
    136159067 (PLCB4)
   04915 Estrogen signaling pathway
    136159067 (PLCB4)
   04921 Oxytocin signaling pathway
    136159067 (PLCB4)
   04926 Relaxin signaling pathway
    136159067 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    136159067 (PLCB4)
   04918 Thyroid hormone synthesis
    136159067 (PLCB4)
   04919 Thyroid hormone signaling pathway
    136159067 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    136159067 (PLCB4)
   04916 Melanogenesis
    136159067 (PLCB4)
   04924 Renin secretion
    136159067 (PLCB4)
   04925 Aldosterone synthesis and secretion
    136159067 (PLCB4)
   04927 Cortisol synthesis and secretion
    136159067 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    136159067 (PLCB4)
   04270 Vascular smooth muscle contraction
    136159067 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    136159067 (PLCB4)
   04971 Gastric acid secretion
    136159067 (PLCB4)
   04972 Pancreatic secretion
    136159067 (PLCB4)
   04973 Carbohydrate digestion and absorption
    136159067 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    136159067 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    136159067 (PLCB4)
   04725 Cholinergic synapse
    136159067 (PLCB4)
   04728 Dopaminergic synapse
    136159067 (PLCB4)
   04726 Serotonergic synapse
    136159067 (PLCB4)
   04720 Long-term potentiation
    136159067 (PLCB4)
   04730 Long-term depression
    136159067 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    136159067 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    136159067 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    136159067 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    136159067 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136159067 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    136159067 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    136159067 (PLCB4)
   05142 Chagas disease
    136159067 (PLCB4)
   05143 African trypanosomiasis
    136159067 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136159067 (PLCB4)
   05016 Huntington disease
    136159067 (PLCB4)
   05017 Spinocerebellar ataxia
    136159067 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    136159067 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    136159067 (PLCB4)
   05415 Diabetic cardiomyopathy
    136159067 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    136159067 (PLCB4)
   04934 Cushing syndrome
    136159067 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mree04131]
    136159067 (PLCB4)
Enzymes [BR:mree01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     136159067 (PLCB4)
Membrane trafficking [BR:mree04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    136159067 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    136159067 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 136159067
NCBI-ProteinID: XP_065776926
Position
2:1862962..2314818
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
ITKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGKQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENSKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNV
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHVSLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDRKGKTNTAKANVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKLTHEKVLEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAQQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCV
KLQDTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtagacgaatttggcttctttctgacctggagaagtgaaggcaaggaaggccaagtgcta
gaatgttccctcatcaacagtgttcggctgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctcttggcaaatcagaaaatgatctggaaggacggatagtctgtgtc
tgcagtggtgcagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
ataacgaagcaatgggtggatggcctgagatccatcatacacaacttcagggcgaacaac
gtcagcccgatgacgtgcctcaagaagcactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgacgaaattgag
cctgctgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagat
ttgaagaaacaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aacgcccccgtcttcctagatcgtctagagctgtaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcaaacagtttggtgggaaa
tcttccgtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatgggaaaggtgaggaccaagaaccgataataactcatggaaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcctttgtcacatcg
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcagacccttgccatcaccgaatgacctcaaaagaaaaatactcatc
aaaaacaaacgactgaaacctgaggttgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagcaggagaatccgctgccccggtgaacatcttagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaggaagctcaccctgaatacaaatatggaaatgaactt
tctgcagatgacttgggtcacaaggaagctattgccaatagtgtcaagaaggcttcagat
gaccttgaacatgaaaacagcaaaaagggcctggttaccgtagaagatgagcaggcgtgg
atggcatcttataaatatgtgggtgctaccactaatatccatccgtatttgtccacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagaacgcaatgtt
cattataacatgtcttcttttaatgagtcggttggtctaggctacttgaagacacacgcc
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcaggggaaatttgagtataat
ggatcatgcgggtaccttctcaagccagatttcatgagacggcccgatcgaacctttgat
cccttctcggaaacacctgttgacggggtgattgcagccacgtgctctgtgcaggtcata
tcaggtcagttcttatcagataagaaaattggcacatatgtagaagtggacatgtatggg
ctgcccacggacactatccgaaaggaattccgcactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtgatcctccctgacctggct
gtcttgaggatcgccgtgtatgatgacaacaacaagctgataggccagaggattctgccc
ctggacggcctccaagcaggctatcgacacgtatccctccgaaatgagggcaataaacct
ttatcgctgccaaccattttctgcaatattgtcctaaaaacatatgtgcctgatggattc
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagatcaaatgagagctatgggcattgaaactagtgacatcgccgatgtgcccagtgac
acttcaaagaacgacaggaaagggaaaaccaacacagccaaagctaatgtgacccctcag
agcagctcggagctcaggccgaccaccacagctgccctgggggctggcctggaggccaag
aaaggtattgaactgatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaagagctcaattctttaaagaagaagcatgcaaag
gaacacagtaccatgcagaaactgcactgcacgcaagttgacaagattgtggcccagtac
gacaaggagaagctgacgcatgagaaagtcctggagaaggcgatgaagaagaaaggggga
agtaattgccttgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagatcgtagcacagcacacaaaggagtggtcagacatgatc
aacacccacagtgcggaggagcaggagatccgggacctgcacctcagccagcagtgcgag
ctgctcagaaagctcctgatcagcgcccacgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaagagatgcgagcacagcaagctaagatttctatggaaaacagc
aaagccatcagccaagataagtccatcaagaataaagcagaacgggaaaggagagtcagg
gagttaaacagcagcaacacgaaaaagtttctggaagaaagaaagcgacttgccatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgagcacctcgaattcctagag
aaacagaatgagcagcttttgaaatcctgtcacgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacacaaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (9)   
   Pfam (9)   
All databases (23)   

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