KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110575943
Entry
110575943         CDS       T08474                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00562  Inositol phosphate metabolism
nsu01100  Metabolic pathways
nsu04015  Rap1 signaling pathway
nsu04020  Calcium signaling pathway
nsu04022  cGMP-PKG signaling pathway
nsu04062  Chemokine signaling pathway
nsu04070  Phosphatidylinositol signaling system
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04081  Hormone signaling
nsu04082  Neuroactive ligand signaling
nsu04261  Adrenergic signaling in cardiomyocytes
nsu04270  Vascular smooth muscle contraction
nsu04310  Wnt signaling pathway
nsu04371  Apelin signaling pathway
nsu04540  Gap junction
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04621  NOD-like receptor signaling pathway
nsu04713  Circadian entrainment
nsu04720  Long-term potentiation
nsu04723  Retrograde endocannabinoid signaling
nsu04724  Glutamatergic synapse
nsu04725  Cholinergic synapse
nsu04726  Serotonergic synapse
nsu04728  Dopaminergic synapse
nsu04730  Long-term depression
nsu04742  Taste transduction
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04911  Insulin secretion
nsu04912  GnRH signaling pathway
nsu04915  Estrogen signaling pathway
nsu04916  Melanogenesis
nsu04918  Thyroid hormone synthesis
nsu04919  Thyroid hormone signaling pathway
nsu04921  Oxytocin signaling pathway
nsu04922  Glucagon signaling pathway
nsu04924  Renin secretion
nsu04925  Aldosterone synthesis and secretion
nsu04926  Relaxin signaling pathway
nsu04927  Cortisol synthesis and secretion
nsu04928  Parathyroid hormone synthesis, secretion and action
nsu04929  GnRH secretion
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04934  Cushing syndrome
nsu04935  Growth hormone synthesis, secretion and action
nsu04961  Endocrine and other factor-regulated calcium reabsorption
nsu04970  Salivary secretion
nsu04971  Gastric acid secretion
nsu04972  Pancreatic secretion
nsu04973  Carbohydrate digestion and absorption
nsu05010  Alzheimer disease
nsu05016  Huntington disease
nsu05017  Spinocerebellar ataxia
nsu05022  Pathways of neurodegeneration - multiple diseases
nsu05142  Chagas disease
nsu05143  African trypanosomiasis
nsu05146  Amoebiasis
nsu05163  Human cytomegalovirus infection
nsu05200  Pathways in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
Module
nsu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110575943 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    110575943 (PLCB3)
   04310 Wnt signaling pathway
    110575943 (PLCB3)
   04371 Apelin signaling pathway
    110575943 (PLCB3)
   04020 Calcium signaling pathway
    110575943 (PLCB3)
   04070 Phosphatidylinositol signaling system
    110575943 (PLCB3)
   04072 Phospholipase D signaling pathway
    110575943 (PLCB3)
   04071 Sphingolipid signaling pathway
    110575943 (PLCB3)
   04022 cGMP-PKG signaling pathway
    110575943 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    110575943 (PLCB3)
   04081 Hormone signaling
    110575943 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    110575943 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110575943 (PLCB3)
   04613 Neutrophil extracellular trap formation
    110575943 (PLCB3)
   04621 NOD-like receptor signaling pathway
    110575943 (PLCB3)
   04062 Chemokine signaling pathway
    110575943 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    110575943 (PLCB3)
   04922 Glucagon signaling pathway
    110575943 (PLCB3)
   04929 GnRH secretion
    110575943 (PLCB3)
   04912 GnRH signaling pathway
    110575943 (PLCB3)
   04915 Estrogen signaling pathway
    110575943 (PLCB3)
   04921 Oxytocin signaling pathway
    110575943 (PLCB3)
   04926 Relaxin signaling pathway
    110575943 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    110575943 (PLCB3)
   04918 Thyroid hormone synthesis
    110575943 (PLCB3)
   04919 Thyroid hormone signaling pathway
    110575943 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    110575943 (PLCB3)
   04916 Melanogenesis
    110575943 (PLCB3)
   04924 Renin secretion
    110575943 (PLCB3)
   04925 Aldosterone synthesis and secretion
    110575943 (PLCB3)
   04927 Cortisol synthesis and secretion
    110575943 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110575943 (PLCB3)
   04270 Vascular smooth muscle contraction
    110575943 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    110575943 (PLCB3)
   04971 Gastric acid secretion
    110575943 (PLCB3)
   04972 Pancreatic secretion
    110575943 (PLCB3)
   04973 Carbohydrate digestion and absorption
    110575943 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110575943 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    110575943 (PLCB3)
   04725 Cholinergic synapse
    110575943 (PLCB3)
   04728 Dopaminergic synapse
    110575943 (PLCB3)
   04726 Serotonergic synapse
    110575943 (PLCB3)
   04720 Long-term potentiation
    110575943 (PLCB3)
   04730 Long-term depression
    110575943 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    110575943 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    110575943 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    110575943 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110575943 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110575943 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    110575943 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110575943 (PLCB3)
   05142 Chagas disease
    110575943 (PLCB3)
   05143 African trypanosomiasis
    110575943 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110575943 (PLCB3)
   05016 Huntington disease
    110575943 (PLCB3)
   05017 Spinocerebellar ataxia
    110575943 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    110575943 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110575943 (PLCB3)
   05415 Diabetic cardiomyopathy
    110575943 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110575943 (PLCB3)
   04934 Cushing syndrome
    110575943 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nsu04131]
    110575943 (PLCB3)
Enzymes [BR:nsu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     110575943 (PLCB3)
Membrane trafficking [BR:nsu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    110575943 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    110575943 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 110575943
NCBI-ProteinID: XP_021540661
UniProt: A0A2Y9GN71
Position
11:complement(8006618..8022181)
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTYLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAAGVPLPSPQDLMGRILVKNKKRHRPSTAVPNS
SVRKRPLEQSNSALSEGSATTEPSSPQLGSPSSDSCPGLSNGEEVGLEKPNLEPRKSLGE
DGLQRGPDALGSADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRVAAFEEGGKFVGHRILPVSAVRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQPQQL
GSQLTPNPTPSPLDTSPRRPPGPATSPTSSSLSSPGQRDDLIASLLSEVAPVPLDELRGH
KALVKLRSRQERELRELHKKHQRKAVALTRRLLDGLAQARAESKCHQRPGVLGGENEKEE
EEEVKRYQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQQRLREIVLDAHATQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLAAGQQQALQQLVEEEPKLLAQLARECQEQRARLPQEIRRSLLGETPEALGDGHL
VACASNGHAPGSGGPLSGADSESQEENTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcctggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgaggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactccaatggcttctttctgtactggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacggggcgttatgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgcccggctggag
gagaagttaatgacggtggtggctgggccagacccggtgaatacgacatacttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaagctggccatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgaaaagcatacacaaagctg
aagctgcaggtgaaccaggatggacggatcccggtgaagaatatcctcaagatgttttca
gcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcccgacgagttttccttggaaatcttcgagcggttcctgaataagttg
tgtctgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaagtgctgtacccacccttgcgcccctcccaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggaaggcttcagccgctacctg
ggaggtgaggagaatggcatcctgcccctggaggccctggatctgagcgcagacatgacc
cagccgctgagcgcctacttcatcaactcctcacacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgtcgctgc
gtggagctggacgtgtggaaagggcggccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccgctgcgggatgtgctcgaggccatcgccgagaccgcc
ttcaagacctcgccctaccctgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgttccatctttggggacgcgctgctcatcgac
ccgctggacaagtacccgctggccgcaggcgtccccctgcctagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccggcccagcaccgctgtccccaacagc
tctgtgcgcaagcggccgctggagcagagcaactcggccctgagcgagggctctgccacc
actgagccctcctcacctcagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaagaggtgggtctggagaagcccaacctggagcctcggaagtctttgggcgag
gatgggctacagcggggccctgatgctcttggatctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaagaacagacagatcctaaaaagccgaccacggatgagggcacagcc
agcagtgaggtcaatgccaccgaggaaatgtcaacactcgtcaactacatcgagcccgtc
aagttcaagtcatttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatccttc
gtggaaaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aaacagcagctcagccgcatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaacgtcggctgccagcttgttgcgctcaacttccagaccctggac
gtggcgatgcagctcaacgcaggcgtgttcgagtacaacgggcgcagtggctacctgctc
aagcccgagttcatgcggcggccagacaagtccttcgatcccttcaccgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctttccgac
aggaaggtgggcatctatgtggaggtggacatgttcggcctccccgtggacacgcggcgc
aagtaccgcactcggacctctcaagggaactccttcaatcccgtgtgggacgaggagccc
tttgacttccccaaggtggtgctgcccacactagcttcgctgcgcgtcgcggccttcgag
gagggcggcaagttcgtggggcatcggattctgcccgtctcggctgtccgctcagggtac
cactacatctgtctgcggaacgaggccaaccagccgctttgcctgccagccctgctcatc
tacaccgaggcctccgactacattcccgacgaccaccaggactacgctgaggccctgatc
aaccccatcaagcacgttagcctgatggaccagagggccaagcagttggccgccctcatt
ggggagagcgaggctcaggctggcccagagacctgccaggagactcagcctcagcagctt
gggtcccagctgaccccaaatcccacacccagcccactggacacctccccacgccggccc
ccaggccctgccacgtcccctaccagctcttccctcagcagcccagggcagcgggacgac
ctcatcgccagtctcctctcagaggtggccccggtcccgctggacgagctccgaggccac
aaggcgctggtgaagctccggagccggcaggagcgagagctgcgggagctgcacaagaag
caccagcggaaggccgtggccctcacgcgccggctgctcgacggcctggcccaggcccgg
gcggagagcaaatgccaccagcggccgggcgtcctaggcggggagaacgagaaggaggag
gaggaagaggtgaagcggtatcaagaattccagaagagacaggtgcagagtctgctggag
ctgagggaggcccaggcggatacagaggctgagcggaggctggagcacctgagacaggct
cagcagcggctcagggagattgtcctggatgctcacgcaactcagttcaagaggctgaag
gagatgaacgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaac
agtatctcagaggccaagacaagggagaaacataagaaggaggcggaactgacagagatt
aaccgccggcacatcaccgagtcggtcaactccatccgtcggctggaggaggcccagaag
cagcggcaagagcgcctcgcggctgggcagcagcaggccctacagcagctggtagaagag
gagcccaagctgctggcccagctggcccgagagtgtcaggagcagcgggcgaggctgccc
caggagatccgccggagcctgctgggcgagacgccggaggcgctgggggacgggcatctg
gtggcctgtgccagcaacgggcacgcacctgggagcggtgggcccctgtctggcgctgac
tcggagagccaagaggagaacaccaagctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (14)   

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