KEGG   Neogale vison (American mink): 122916255
Entry
122916255         CDS       T08764                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs00562  Inositol phosphate metabolism
nvs01100  Metabolic pathways
nvs04015  Rap1 signaling pathway
nvs04020  Calcium signaling pathway
nvs04022  cGMP-PKG signaling pathway
nvs04062  Chemokine signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04081  Hormone signaling
nvs04082  Neuroactive ligand signaling
nvs04261  Adrenergic signaling in cardiomyocytes
nvs04270  Vascular smooth muscle contraction
nvs04310  Wnt signaling pathway
nvs04371  Apelin signaling pathway
nvs04540  Gap junction
nvs04611  Platelet activation
nvs04613  Neutrophil extracellular trap formation
nvs04621  NOD-like receptor signaling pathway
nvs04713  Circadian entrainment
nvs04720  Long-term potentiation
nvs04723  Retrograde endocannabinoid signaling
nvs04724  Glutamatergic synapse
nvs04725  Cholinergic synapse
nvs04726  Serotonergic synapse
nvs04728  Dopaminergic synapse
nvs04730  Long-term depression
nvs04742  Taste transduction
nvs04750  Inflammatory mediator regulation of TRP channels
nvs04911  Insulin secretion
nvs04912  GnRH signaling pathway
nvs04915  Estrogen signaling pathway
nvs04916  Melanogenesis
nvs04918  Thyroid hormone synthesis
nvs04919  Thyroid hormone signaling pathway
nvs04921  Oxytocin signaling pathway
nvs04922  Glucagon signaling pathway
nvs04924  Renin secretion
nvs04925  Aldosterone synthesis and secretion
nvs04926  Relaxin signaling pathway
nvs04927  Cortisol synthesis and secretion
nvs04928  Parathyroid hormone synthesis, secretion and action
nvs04929  GnRH secretion
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04934  Cushing syndrome
nvs04935  Growth hormone synthesis, secretion and action
nvs04961  Endocrine and other factor-regulated calcium reabsorption
nvs04970  Salivary secretion
nvs04971  Gastric acid secretion
nvs04972  Pancreatic secretion
nvs04973  Carbohydrate digestion and absorption
nvs05010  Alzheimer disease
nvs05016  Huntington disease
nvs05017  Spinocerebellar ataxia
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05142  Chagas disease
nvs05143  African trypanosomiasis
nvs05146  Amoebiasis
nvs05163  Human cytomegalovirus infection
nvs05200  Pathways in cancer
nvs05415  Diabetic cardiomyopathy
nvs05417  Lipid and atherosclerosis
Module
nvs_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122916255 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    122916255 (PLCB1)
   04310 Wnt signaling pathway
    122916255 (PLCB1)
   04371 Apelin signaling pathway
    122916255 (PLCB1)
   04020 Calcium signaling pathway
    122916255 (PLCB1)
   04070 Phosphatidylinositol signaling system
    122916255 (PLCB1)
   04072 Phospholipase D signaling pathway
    122916255 (PLCB1)
   04071 Sphingolipid signaling pathway
    122916255 (PLCB1)
   04022 cGMP-PKG signaling pathway
    122916255 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122916255 (PLCB1)
   04081 Hormone signaling
    122916255 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122916255 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122916255 (PLCB1)
   04613 Neutrophil extracellular trap formation
    122916255 (PLCB1)
   04621 NOD-like receptor signaling pathway
    122916255 (PLCB1)
   04062 Chemokine signaling pathway
    122916255 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    122916255 (PLCB1)
   04922 Glucagon signaling pathway
    122916255 (PLCB1)
   04929 GnRH secretion
    122916255 (PLCB1)
   04912 GnRH signaling pathway
    122916255 (PLCB1)
   04915 Estrogen signaling pathway
    122916255 (PLCB1)
   04921 Oxytocin signaling pathway
    122916255 (PLCB1)
   04926 Relaxin signaling pathway
    122916255 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    122916255 (PLCB1)
   04918 Thyroid hormone synthesis
    122916255 (PLCB1)
   04919 Thyroid hormone signaling pathway
    122916255 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    122916255 (PLCB1)
   04916 Melanogenesis
    122916255 (PLCB1)
   04924 Renin secretion
    122916255 (PLCB1)
   04925 Aldosterone synthesis and secretion
    122916255 (PLCB1)
   04927 Cortisol synthesis and secretion
    122916255 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122916255 (PLCB1)
   04270 Vascular smooth muscle contraction
    122916255 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    122916255 (PLCB1)
   04971 Gastric acid secretion
    122916255 (PLCB1)
   04972 Pancreatic secretion
    122916255 (PLCB1)
   04973 Carbohydrate digestion and absorption
    122916255 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    122916255 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    122916255 (PLCB1)
   04725 Cholinergic synapse
    122916255 (PLCB1)
   04728 Dopaminergic synapse
    122916255 (PLCB1)
   04726 Serotonergic synapse
    122916255 (PLCB1)
   04720 Long-term potentiation
    122916255 (PLCB1)
   04730 Long-term depression
    122916255 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    122916255 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    122916255 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    122916255 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122916255 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122916255 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    122916255 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122916255 (PLCB1)
   05142 Chagas disease
    122916255 (PLCB1)
   05143 African trypanosomiasis
    122916255 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122916255 (PLCB1)
   05016 Huntington disease
    122916255 (PLCB1)
   05017 Spinocerebellar ataxia
    122916255 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    122916255 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122916255 (PLCB1)
   05415 Diabetic cardiomyopathy
    122916255 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122916255 (PLCB1)
   04934 Cushing syndrome
    122916255 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nvs04131]
    122916255 (PLCB1)
Enzymes [BR:nvs01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122916255 (PLCB1)
Membrane trafficking [BR:nvs04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122916255 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122916255 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 122916255
NCBI-ProteinID: XP_044119368
Position
8:33710917..34396662
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPVKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHRPPSS
DELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggaccgatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcatgccaaagct
cccaaggaccccaagttacgtgaacttttggatgtggggaacatcgggcgcctggagcat
cgtatgataaccgtggtgtatgggcctgacttggttaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggagtggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaatatgtcaagagatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
actgttgatcagatgatggactttatcaaccttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaaccc
aacaatagtctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcaa
cccctctctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgtcgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccacgggttc
accatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcattt
aagacgtcaccttttccaattctactttcatttgagaaccacgtagattccccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacataagtcgtcagaaggaagtggcaaaaag
aagctctcagaacaagcctccaacacgtacagtgactcttccagcatgtttgagccctcg
tctcccggagccggggaagcggacactgagagtgacgacgacgacgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgccgggagcgaggccatggccactgaagagatg
tctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaatctcaaaaaaa
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggcctcgagcaactgacg
aagtctcccgtggaatttgtggaatataacaaaatgcagcttagcaggatatatccgaaa
ggaacccgtgtggattcatcgaactacatgcctcagctcttctggaatgcaggttgccaa
atggttgcccttaattttcaaactgtggacctcgctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattgaaaccagagttcatgaggaggcctgacaag
cattttgaccccttcaccgaaggcatcgtggatgggatagtggccaacactttatctgtc
aagattatctcaggtcagtttctttccgataagaaagtcgggacttacgtagaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggtccttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaattcattggtcaccgg
atcttgccagtacaagcaattcggccaggctatcactacatctgcctgaggaatgaaagg
aaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtcccc
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctcatg
gagcaaagagctaaacagttagctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggacaactccagca
gaaaacggagtgaatcacactacatccttggcacccaaaccaccatcccaggctctccac
agccaaccagctccaggatctgtaaaggcacctgtgaaaacagaagaccttattcagagt
gtcctaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcctttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacaccacaagaaa
accactgaccttatcaaagaacacactacaaaatataatgagattcagaacgactacttg
agaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagatccc
agcagtcctgaccatggttcatcaacaattgaacaagatcttgctgccctagatgctgaa
atgacccaaaagttaatagacttgaaagataaacaacagcagcagctgcttaatcttcga
caagagcagtattatagtgaaaaatatcagaagcgagaacatattaaactgcttattcaa
aaattgacggatgttgctgaagaatgtcagaataatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggagttaaagaagaagatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcaacagatcctggacgaaaagccc
aagctgcagacagacctggagcaagaataccaagacaagttcaaaagactgcccctggag
atcttggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagcaaccacagc
tctgcccctccctccctggcctcagagcctggaaaaatgaaccacaggcctccctccagt
gacgagctggaaggagacaacccaggaaaagagtttgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (3)   
   GenBank (1)   
   EMBL (1)   
Protein domain (6)   
   Pfam (6)   
All databases (16)   

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