KEGG   Ochotona curzoniae (black-lipped pika): 121163290
Entry
121163290         CDS       T11174                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ocz  Ochotona curzoniae (black-lipped pika)
Pathway
ocz01521  EGFR tyrosine kinase inhibitor resistance
ocz01522  Endocrine resistance
ocz01524  Platinum drug resistance
ocz04012  ErbB signaling pathway
ocz04014  Ras signaling pathway
ocz04015  Rap1 signaling pathway
ocz04024  cAMP signaling pathway
ocz04062  Chemokine signaling pathway
ocz04066  HIF-1 signaling pathway
ocz04068  FoxO signaling pathway
ocz04070  Phosphatidylinositol signaling system
ocz04071  Sphingolipid signaling pathway
ocz04072  Phospholipase D signaling pathway
ocz04081  Hormone signaling
ocz04140  Autophagy - animal
ocz04145  Phagocytosis
ocz04150  mTOR signaling pathway
ocz04151  PI3K-Akt signaling pathway
ocz04152  AMPK signaling pathway
ocz04210  Apoptosis
ocz04211  Longevity regulating pathway
ocz04213  Longevity regulating pathway - multiple species
ocz04218  Cellular senescence
ocz04360  Axon guidance
ocz04370  VEGF signaling pathway
ocz04380  Osteoclast differentiation
ocz04510  Focal adhesion
ocz04517  IgSF CAM signaling
ocz04518  Integrin signaling
ocz04550  Signaling pathways regulating pluripotency of stem cells
ocz04611  Platelet activation
ocz04613  Neutrophil extracellular trap formation
ocz04620  Toll-like receptor signaling pathway
ocz04625  C-type lectin receptor signaling pathway
ocz04630  JAK-STAT signaling pathway
ocz04650  Natural killer cell mediated cytotoxicity
ocz04660  T cell receptor signaling pathway
ocz04662  B cell receptor signaling pathway
ocz04664  Fc epsilon RI signaling pathway
ocz04666  Fc gamma R-mediated phagosome formation
ocz04668  TNF signaling pathway
ocz04670  Leukocyte transendothelial migration
ocz04722  Neurotrophin signaling pathway
ocz04725  Cholinergic synapse
ocz04750  Inflammatory mediator regulation of TRP channels
ocz04810  Regulation of actin cytoskeleton
ocz04910  Insulin signaling pathway
ocz04914  Progesterone-mediated oocyte maturation
ocz04915  Estrogen signaling pathway
ocz04917  Prolactin signaling pathway
ocz04919  Thyroid hormone signaling pathway
ocz04923  Regulation of lipolysis in adipocytes
ocz04926  Relaxin signaling pathway
ocz04929  GnRH secretion
ocz04930  Type II diabetes mellitus
ocz04931  Insulin resistance
ocz04932  Non-alcoholic fatty liver disease
ocz04933  AGE-RAGE signaling pathway in diabetic complications
ocz04935  Growth hormone synthesis, secretion and action
ocz04960  Aldosterone-regulated sodium reabsorption
ocz04973  Carbohydrate digestion and absorption
ocz05010  Alzheimer disease
ocz05017  Spinocerebellar ataxia
ocz05020  Prion disease
ocz05100  Bacterial invasion of epithelial cells
ocz05135  Yersinia infection
ocz05142  Chagas disease
ocz05146  Amoebiasis
ocz05160  Hepatitis C
ocz05161  Hepatitis B
ocz05162  Measles
ocz05163  Human cytomegalovirus infection
ocz05164  Influenza A
ocz05165  Human papillomavirus infection
ocz05166  Human T-cell leukemia virus 1 infection
ocz05167  Kaposi sarcoma-associated herpesvirus infection
ocz05168  Herpes simplex virus 1 infection
ocz05169  Epstein-Barr virus infection
ocz05170  Human immunodeficiency virus 1 infection
ocz05171  Coronavirus disease
ocz05200  Pathways in cancer
ocz05203  Viral carcinogenesis
ocz05205  Proteoglycans in cancer
ocz05206  MicroRNAs in cancer
ocz05207  Chemical carcinogenesis - receptor activation
ocz05208  Chemical carcinogenesis - reactive oxygen species
ocz05210  Colorectal cancer
ocz05211  Renal cell carcinoma
ocz05212  Pancreatic cancer
ocz05213  Endometrial cancer
ocz05214  Glioma
ocz05215  Prostate cancer
ocz05218  Melanoma
ocz05220  Chronic myeloid leukemia
ocz05221  Acute myeloid leukemia
ocz05222  Small cell lung cancer
ocz05223  Non-small cell lung cancer
ocz05224  Breast cancer
ocz05225  Hepatocellular carcinoma
ocz05226  Gastric cancer
ocz05230  Central carbon metabolism in cancer
ocz05231  Choline metabolism in cancer
ocz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocz05415  Diabetic cardiomyopathy
ocz05417  Lipid and atherosclerosis
ocz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    121163290 (PIK3R2)
   04014 Ras signaling pathway
    121163290 (PIK3R2)
   04015 Rap1 signaling pathway
    121163290 (PIK3R2)
   04370 VEGF signaling pathway
    121163290 (PIK3R2)
   04630 JAK-STAT signaling pathway
    121163290 (PIK3R2)
   04668 TNF signaling pathway
    121163290 (PIK3R2)
   04066 HIF-1 signaling pathway
    121163290 (PIK3R2)
   04068 FoxO signaling pathway
    121163290 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    121163290 (PIK3R2)
   04072 Phospholipase D signaling pathway
    121163290 (PIK3R2)
   04071 Sphingolipid signaling pathway
    121163290 (PIK3R2)
   04024 cAMP signaling pathway
    121163290 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    121163290 (PIK3R2)
   04152 AMPK signaling pathway
    121163290 (PIK3R2)
   04150 mTOR signaling pathway
    121163290 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121163290 (PIK3R2)
   04517 IgSF CAM signaling
    121163290 (PIK3R2)
   04518 Integrin signaling
    121163290 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    121163290 (PIK3R2)
   04140 Autophagy - animal
    121163290 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    121163290 (PIK3R2)
   04218 Cellular senescence
    121163290 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121163290 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    121163290 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121163290 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121163290 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    121163290 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    121163290 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    121163290 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    121163290 (PIK3R2)
   04660 T cell receptor signaling pathway
    121163290 (PIK3R2)
   04662 B cell receptor signaling pathway
    121163290 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    121163290 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    121163290 (PIK3R2)
   04670 Leukocyte transendothelial migration
    121163290 (PIK3R2)
   04062 Chemokine signaling pathway
    121163290 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121163290 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    121163290 (PIK3R2)
   04929 GnRH secretion
    121163290 (PIK3R2)
   04915 Estrogen signaling pathway
    121163290 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    121163290 (PIK3R2)
   04917 Prolactin signaling pathway
    121163290 (PIK3R2)
   04926 Relaxin signaling pathway
    121163290 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    121163290 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    121163290 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121163290 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121163290 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    121163290 (PIK3R2)
   04722 Neurotrophin signaling pathway
    121163290 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121163290 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    121163290 (PIK3R2)
   04380 Osteoclast differentiation
    121163290 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    121163290 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    121163290 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121163290 (PIK3R2)
   05206 MicroRNAs in cancer
    121163290 (PIK3R2)
   05205 Proteoglycans in cancer
    121163290 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    121163290 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    121163290 (PIK3R2)
   05203 Viral carcinogenesis
    121163290 (PIK3R2)
   05230 Central carbon metabolism in cancer
    121163290 (PIK3R2)
   05231 Choline metabolism in cancer
    121163290 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121163290 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121163290 (PIK3R2)
   05212 Pancreatic cancer
    121163290 (PIK3R2)
   05225 Hepatocellular carcinoma
    121163290 (PIK3R2)
   05226 Gastric cancer
    121163290 (PIK3R2)
   05214 Glioma
    121163290 (PIK3R2)
   05221 Acute myeloid leukemia
    121163290 (PIK3R2)
   05220 Chronic myeloid leukemia
    121163290 (PIK3R2)
   05218 Melanoma
    121163290 (PIK3R2)
   05211 Renal cell carcinoma
    121163290 (PIK3R2)
   05215 Prostate cancer
    121163290 (PIK3R2)
   05213 Endometrial cancer
    121163290 (PIK3R2)
   05224 Breast cancer
    121163290 (PIK3R2)
   05222 Small cell lung cancer
    121163290 (PIK3R2)
   05223 Non-small cell lung cancer
    121163290 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121163290 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    121163290 (PIK3R2)
   05161 Hepatitis B
    121163290 (PIK3R2)
   05160 Hepatitis C
    121163290 (PIK3R2)
   05171 Coronavirus disease
    121163290 (PIK3R2)
   05164 Influenza A
    121163290 (PIK3R2)
   05162 Measles
    121163290 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    121163290 (PIK3R2)
   05163 Human cytomegalovirus infection
    121163290 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121163290 (PIK3R2)
   05169 Epstein-Barr virus infection
    121163290 (PIK3R2)
   05165 Human papillomavirus infection
    121163290 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    121163290 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    121163290 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121163290 (PIK3R2)
   05142 Chagas disease
    121163290 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121163290 (PIK3R2)
   05017 Spinocerebellar ataxia
    121163290 (PIK3R2)
   05020 Prion disease
    121163290 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121163290 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    121163290 (PIK3R2)
   05415 Diabetic cardiomyopathy
    121163290 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121163290 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    121163290 (PIK3R2)
   04931 Insulin resistance
    121163290 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121163290 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121163290 (PIK3R2)
   01524 Platinum drug resistance
    121163290 (PIK3R2)
   01522 Endocrine resistance
    121163290 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocz04131]
    121163290 (PIK3R2)
Membrane trafficking [BR:ocz04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121163290 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP ODF2_C SH3_1 SH2_1 SH3_9 DicA_C Ribosomal_L22e
Other DBs
NCBI-GeneID: 121163290
NCBI-ProteinID: XP_040846693
Position
Unknown
AA seq 724 aa
MAGAESFQYRALYPFRRERPEDLELLPGDVLVVSRVALQALGVAEGGERCPHSVGWMPGF
NERTRQRGDFPGTYVEFLGPVAAARPGPRPRGPRPLPARPREGAPESGSTLPDLPEQFSP
PDAAPPLLVKLVEALEQTGVDTECYLRPELPAPRTDWSLSDLDQWDAAALSDAIKSFLLA
LPAPLVTPEAAAEAHQALREASAPVGPVLEPPTLPLHRALTLRFLLQHLGRLARRAPTPS
TAIRALGAIVGPLLLRVPPPGGAPDGSEPNPDFPALLVEKLLQEQLEEQELAPPALPPKP
AKTKPAPAGLANGGSPSSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYT
LTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLIAHYRHESLAQYNAKLDTRLLYPVS
KYQQDQIVKEDSVEAVGAQLKVYHQQFQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNE
TIRIFEEQGQTQEKYSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRSKLEQEL
RAQASDNREIDKRINSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNDAEDQYA
LMDEDEDLPHHEERTWYVGNINRTQAEEMLSGKRDGTFLVRESSQRGCYACSVVVDGDTK
HCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVLAPGPGPGPP
PAAR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atggcgggcgccgagagcttccagtaccgggcgctctacccgttccgccgggagcggccg
gaggacctggagctgctgccgggcgacgtgctggtggtgagccgggtcgccctgcaggcc
ctcggcgtggccgagggcggggaacgctgcccgcacagcgtgggctggatgcccggcttc
aacgagcgcacgcggcagcgcggagacttccccgggacctacgtggagttcctggggccc
gtggccgctgcccggcccggccctcggccgcgaggaccccgtccactgccggccaggccc
agggagggcgctcccgagtcaggctccaccctccctgacctgccagagcagttctcgccg
cccgacgcagccccgccgctgctggtgaagctggtagaagccttggaacagacaggagtg
gacactgagtgctacttgaggcccgagctgcccgcaccgcgcacagactggtccctgagc
gacctggaccagtgggacgcagccgccctgtcggacgccatcaagagcttcctcctggcc
ttgcctgcgcccctggtcaccccggaggctgcagccgaggcgcaccaggccctgcgggag
gcctcggcgcccgtggggccggtgctggagccgcccacgctgccgctgcaccgcgctctc
acgctgcgcttcctgctccagcacctgggccggctggcccggcgcgccccgaccccaagc
accgccatccgcgccctgggcgccatcgtggggccgctgctgctgcgcgtgccgccgcca
gggggcgcgcccgacgggagcgagccgaaccccgacttcccggcgctgctggtggaaaag
ctacttcaagaacagctggaggagcaggagttggcgcccccagcgctgccccctaaacct
gccaaaaccaagccagcccctgcaggcctggccaacggggggagcccctcgtccctgcag
gacgccgagtggtactggggagacatctccagggaggaggtgaatgagaagctgcgagac
accccagatggcaccttcctggtccgggacgcgtccagcaagatccagggggagtacacg
ctgacgctcaggaagggcggtaacaacaagctgatcaaggtgttccaccgagacggccac
tacggcttctcggagccgctgaccttctgctcggtggtggacctcatcgcgcactaccgg
cacgagtcgctggcgcagtacaacgccaagctggacacgcggctgctctaccccgtgtcc
aagtaccagcaggaccagatcgtgaaggaagacagcgtggaggcggtgggcgcgcagctc
aaggtctaccaccagcaattccaggacaagagccgggagtacgaccagctctacgaggaa
tacacacgcacctcccaggagctgcagatgaagcgtacggccatcgaggccttcaacgag
accatcaggatcttcgaggagcagggccagacgcaggagaagtacagcaaggagtacctg
gagcgcttccgacgggagggcaacgagaaggagatgcagaggatcctgctgaactcggag
cgtctcaagtctcgcatcgccgagatccacgagagccgcagcaagctggagcaggagctg
cgcgcgcaggcctcggacaaccgcgagatcgacaagcgcatcaacagcctcaagcccgac
ctgatgcagctgcgcaagatccgggaccagtacctcgtgtggctcacccagaaaggtgcc
cggcagaagaaaatcaacgagtggctggggatcaaaaacgatgctgaggaccagtacgcc
ctgatggacgaggacgaggacctgccccaccacgaggagcgcacgtggtacgtgggcaat
atcaaccgcacccaggccgaggagatgctgagcggcaagcgggatggcaccttcctggtg
cgggagagcagccagcggggctgctatgcctgctcggtggtcgtggacggggacacgaag
cactgtgtcatctatcgcacggccaccggcttcggcttcgccgagccctacaacctgtac
ggctccctgaaggagctggtcctgcactaccaacacgcctcgctcgtgcagcacaacgat
gccctcaccgtcacgctggcccacccggtgctcgcccccgggcccgggcccgggcctcca
cccgccgcgcgctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (13)   

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