KEGG   Orcinus orca (killer whale): 101270548
Entry
101270548         CDS       T05247                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor00562  Inositol phosphate metabolism
oor01100  Metabolic pathways
oor04015  Rap1 signaling pathway
oor04020  Calcium signaling pathway
oor04022  cGMP-PKG signaling pathway
oor04062  Chemokine signaling pathway
oor04070  Phosphatidylinositol signaling system
oor04071  Sphingolipid signaling pathway
oor04072  Phospholipase D signaling pathway
oor04081  Hormone signaling
oor04082  Neuroactive ligand signaling
oor04261  Adrenergic signaling in cardiomyocytes
oor04270  Vascular smooth muscle contraction
oor04310  Wnt signaling pathway
oor04371  Apelin signaling pathway
oor04540  Gap junction
oor04611  Platelet activation
oor04613  Neutrophil extracellular trap formation
oor04621  NOD-like receptor signaling pathway
oor04713  Circadian entrainment
oor04720  Long-term potentiation
oor04723  Retrograde endocannabinoid signaling
oor04724  Glutamatergic synapse
oor04725  Cholinergic synapse
oor04726  Serotonergic synapse
oor04728  Dopaminergic synapse
oor04730  Long-term depression
oor04742  Taste transduction
oor04750  Inflammatory mediator regulation of TRP channels
oor04911  Insulin secretion
oor04912  GnRH signaling pathway
oor04915  Estrogen signaling pathway
oor04916  Melanogenesis
oor04918  Thyroid hormone synthesis
oor04919  Thyroid hormone signaling pathway
oor04921  Oxytocin signaling pathway
oor04922  Glucagon signaling pathway
oor04924  Renin secretion
oor04925  Aldosterone synthesis and secretion
oor04926  Relaxin signaling pathway
oor04927  Cortisol synthesis and secretion
oor04928  Parathyroid hormone synthesis, secretion and action
oor04929  GnRH secretion
oor04933  AGE-RAGE signaling pathway in diabetic complications
oor04934  Cushing syndrome
oor04935  Growth hormone synthesis, secretion and action
oor04961  Endocrine and other factor-regulated calcium reabsorption
oor04970  Salivary secretion
oor04971  Gastric acid secretion
oor04972  Pancreatic secretion
oor04973  Carbohydrate digestion and absorption
oor05010  Alzheimer disease
oor05016  Huntington disease
oor05017  Spinocerebellar ataxia
oor05022  Pathways of neurodegeneration - multiple diseases
oor05142  Chagas disease
oor05143  African trypanosomiasis
oor05146  Amoebiasis
oor05163  Human cytomegalovirus infection
oor05200  Pathways in cancer
oor05415  Diabetic cardiomyopathy
oor05417  Lipid and atherosclerosis
Module
oor_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oor00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101270548 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101270548 (PLCB1)
   04310 Wnt signaling pathway
    101270548 (PLCB1)
   04371 Apelin signaling pathway
    101270548 (PLCB1)
   04020 Calcium signaling pathway
    101270548 (PLCB1)
   04070 Phosphatidylinositol signaling system
    101270548 (PLCB1)
   04072 Phospholipase D signaling pathway
    101270548 (PLCB1)
   04071 Sphingolipid signaling pathway
    101270548 (PLCB1)
   04022 cGMP-PKG signaling pathway
    101270548 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101270548 (PLCB1)
   04081 Hormone signaling
    101270548 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101270548 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101270548 (PLCB1)
   04613 Neutrophil extracellular trap formation
    101270548 (PLCB1)
   04621 NOD-like receptor signaling pathway
    101270548 (PLCB1)
   04062 Chemokine signaling pathway
    101270548 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    101270548 (PLCB1)
   04922 Glucagon signaling pathway
    101270548 (PLCB1)
   04929 GnRH secretion
    101270548 (PLCB1)
   04912 GnRH signaling pathway
    101270548 (PLCB1)
   04915 Estrogen signaling pathway
    101270548 (PLCB1)
   04921 Oxytocin signaling pathway
    101270548 (PLCB1)
   04926 Relaxin signaling pathway
    101270548 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    101270548 (PLCB1)
   04918 Thyroid hormone synthesis
    101270548 (PLCB1)
   04919 Thyroid hormone signaling pathway
    101270548 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    101270548 (PLCB1)
   04916 Melanogenesis
    101270548 (PLCB1)
   04924 Renin secretion
    101270548 (PLCB1)
   04925 Aldosterone synthesis and secretion
    101270548 (PLCB1)
   04927 Cortisol synthesis and secretion
    101270548 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101270548 (PLCB1)
   04270 Vascular smooth muscle contraction
    101270548 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    101270548 (PLCB1)
   04971 Gastric acid secretion
    101270548 (PLCB1)
   04972 Pancreatic secretion
    101270548 (PLCB1)
   04973 Carbohydrate digestion and absorption
    101270548 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101270548 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    101270548 (PLCB1)
   04725 Cholinergic synapse
    101270548 (PLCB1)
   04728 Dopaminergic synapse
    101270548 (PLCB1)
   04726 Serotonergic synapse
    101270548 (PLCB1)
   04720 Long-term potentiation
    101270548 (PLCB1)
   04730 Long-term depression
    101270548 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    101270548 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    101270548 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    101270548 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101270548 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101270548 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101270548 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101270548 (PLCB1)
   05142 Chagas disease
    101270548 (PLCB1)
   05143 African trypanosomiasis
    101270548 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101270548 (PLCB1)
   05016 Huntington disease
    101270548 (PLCB1)
   05017 Spinocerebellar ataxia
    101270548 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    101270548 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101270548 (PLCB1)
   05415 Diabetic cardiomyopathy
    101270548 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101270548 (PLCB1)
   04934 Cushing syndrome
    101270548 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oor04131]
    101270548 (PLCB1)
Enzymes [BR:oor01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101270548 (PLCB1)
Membrane trafficking [BR:oor04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101270548 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101270548 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 101270548
NCBI-ProteinID: XP_004276506
Position
16:35538578..36218361
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQSKE
TELLDISLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDLIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
GEENGVVPPEKLDLNEDMSQPLTHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPLDLMYKILVKNKKKSHKSSEGSGKK
KLSEQTSNTYSDSSSVFEPSSPGAGEADTESDDDDDEDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETQSEAPSEARTTPAENGMNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSVPPLLTSDPGKLNHKPPSS
EKLEGENPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtacacgctctgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtcactcca
attattttgaggaccgaccctcagggatttttcttttactggacagatcaaagcaaggag
acggagctgttagatatcagccttgtcaaagatgccagatgtgggaaacacgccaaggct
cccaaggaccccaaattacgtgaacttctggatgtggggaacatcgggcgcctggaacat
cgcatgataacagtggtgtatgggcctgacttagttaacatctcccatttgaaccttgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtctggcaacgaac
ctgctggcccaaaacatgtctagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
ttgatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
acagttgatcagatgatggattttatcaacctcaagcagcgagatcccaggctaaatgaa
attctttacccacctttaaagcaagagcaagtccaggtgttgattgagaagtatgaaccc
aacaacagtcttgccagaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaggaaaatggagtcgttccacctgagaaactggatttgaatgaagatatgtctcag
ccacttactcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctctgtcgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggaccgcagaagaggagccagtcatcacccatgggttc
accatgaccacggagatatccttcaaggaagtgatagaagccattgctgagtgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccacgtggattccccaaagcag
caggccaagatggcagagtattgccgactgatcttcggggacgcccttctcatggagccc
ctggaaaagtacccactggaatccggagttcctcttccaagccctctggacttaatgtac
aaaattttggtgaaaaataagaagaaatcccacaaatcgtcagaaggaagtggcaaaaag
aagctctcagaacagacctccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagctggagaagctgatacggagagtgacgatgatgacgatgaggatgactgt
aaaaagtcctcgatggatgaggggactgctgggagcgaggccatggccacagaagagatg
tctaatctggtgaactatattcagccagtcaagttcgagtcattcgaaatttcaaaaaaa
agaaacagaagcttcgaaatgtcttcctttgtggaaaccaaaggacttgagcaacttaca
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactacatgccccagctcttctggaacgcaggctgccaa
atggttgcacttaatttccaaacagtggacctggctatgcaaataaacatggggatgtat
gaatacaatgggaaaagtggctacagactgaagccagagttcatgaggagacctgacaag
cactttgatccattcaccgaaggcattgtggatgggatcgtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagacaaagacatcacaagga
aatgctgtaaatcctgtctgggaagaagaacccattgtgttcaaaaaggtagttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcgaccaggctatcactacatctgtctgaggaatgaaagg
aaccagcctctgatgctgccagctctctttgtctacatagaggtgaaggactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggcagctttgacgctggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacacagtcagaagctccaagtgaagccaggacaactccagca
gaaaacgggatgaatcacactacatccctgacacccaaaccaccctcccaggctctccac
agccaaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacaattgaagagctgaagcaacaaaagtcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaagagacaccacaagaaa
accaccgaccttatcaaagaacacactacaaaatataatgaaatccagaatgactacttg
cgaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcggaaccc
agcagccctgaccatggttcgtcaacaattgagcaagaccttgctgccctggatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagaacagtattacagcgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacagatgttgctgaagaatgtcagaataatcagttaaagaagcttaaagaaatt
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatccaaagacaaaagccagatggaagaggaaaaaacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaagagatacgtcagcagatcctggacgaaaagccc
aagctgcaggtggagctagagcaggagtaccaagacaagttcaaaaggctgcccctggag
attttggaattcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagc
tctgtccctcccctgctgacctcagaccctggaaaactgaaccacaagcctccttccagt
gagaagctggaaggagaaaacccaggaaaagaatttgatactcccctgtga

  All links  
Gene (15)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (6)   
   Pfam (6)   
All databases (25)   

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