KEGG   Ochotona princeps (American pika): 101529337
Entry
101529337         CDS       T07609                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi00562  Inositol phosphate metabolism
opi01100  Metabolic pathways
opi04015  Rap1 signaling pathway
opi04020  Calcium signaling pathway
opi04022  cGMP-PKG signaling pathway
opi04062  Chemokine signaling pathway
opi04070  Phosphatidylinositol signaling system
opi04071  Sphingolipid signaling pathway
opi04072  Phospholipase D signaling pathway
opi04081  Hormone signaling
opi04082  Neuroactive ligand signaling
opi04261  Adrenergic signaling in cardiomyocytes
opi04270  Vascular smooth muscle contraction
opi04310  Wnt signaling pathway
opi04371  Apelin signaling pathway
opi04540  Gap junction
opi04611  Platelet activation
opi04613  Neutrophil extracellular trap formation
opi04621  NOD-like receptor signaling pathway
opi04713  Circadian entrainment
opi04720  Long-term potentiation
opi04723  Retrograde endocannabinoid signaling
opi04724  Glutamatergic synapse
opi04725  Cholinergic synapse
opi04726  Serotonergic synapse
opi04728  Dopaminergic synapse
opi04730  Long-term depression
opi04742  Taste transduction
opi04750  Inflammatory mediator regulation of TRP channels
opi04911  Insulin secretion
opi04912  GnRH signaling pathway
opi04915  Estrogen signaling pathway
opi04916  Melanogenesis
opi04918  Thyroid hormone synthesis
opi04919  Thyroid hormone signaling pathway
opi04921  Oxytocin signaling pathway
opi04922  Glucagon signaling pathway
opi04924  Renin secretion
opi04925  Aldosterone synthesis and secretion
opi04926  Relaxin signaling pathway
opi04927  Cortisol synthesis and secretion
opi04928  Parathyroid hormone synthesis, secretion and action
opi04929  GnRH secretion
opi04933  AGE-RAGE signaling pathway in diabetic complications
opi04934  Cushing syndrome
opi04935  Growth hormone synthesis, secretion and action
opi04961  Endocrine and other factor-regulated calcium reabsorption
opi04970  Salivary secretion
opi04971  Gastric acid secretion
opi04972  Pancreatic secretion
opi04973  Carbohydrate digestion and absorption
opi05010  Alzheimer disease
opi05016  Huntington disease
opi05017  Spinocerebellar ataxia
opi05022  Pathways of neurodegeneration - multiple diseases
opi05142  Chagas disease
opi05143  African trypanosomiasis
opi05146  Amoebiasis
opi05163  Human cytomegalovirus infection
opi05200  Pathways in cancer
opi05415  Diabetic cardiomyopathy
opi05417  Lipid and atherosclerosis
Module
opi_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:opi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101529337 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101529337 (PLCB2)
   04310 Wnt signaling pathway
    101529337 (PLCB2)
   04371 Apelin signaling pathway
    101529337 (PLCB2)
   04020 Calcium signaling pathway
    101529337 (PLCB2)
   04070 Phosphatidylinositol signaling system
    101529337 (PLCB2)
   04072 Phospholipase D signaling pathway
    101529337 (PLCB2)
   04071 Sphingolipid signaling pathway
    101529337 (PLCB2)
   04022 cGMP-PKG signaling pathway
    101529337 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101529337 (PLCB2)
   04081 Hormone signaling
    101529337 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101529337 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101529337 (PLCB2)
   04613 Neutrophil extracellular trap formation
    101529337 (PLCB2)
   04621 NOD-like receptor signaling pathway
    101529337 (PLCB2)
   04062 Chemokine signaling pathway
    101529337 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    101529337 (PLCB2)
   04922 Glucagon signaling pathway
    101529337 (PLCB2)
   04929 GnRH secretion
    101529337 (PLCB2)
   04912 GnRH signaling pathway
    101529337 (PLCB2)
   04915 Estrogen signaling pathway
    101529337 (PLCB2)
   04921 Oxytocin signaling pathway
    101529337 (PLCB2)
   04926 Relaxin signaling pathway
    101529337 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    101529337 (PLCB2)
   04918 Thyroid hormone synthesis
    101529337 (PLCB2)
   04919 Thyroid hormone signaling pathway
    101529337 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    101529337 (PLCB2)
   04916 Melanogenesis
    101529337 (PLCB2)
   04924 Renin secretion
    101529337 (PLCB2)
   04925 Aldosterone synthesis and secretion
    101529337 (PLCB2)
   04927 Cortisol synthesis and secretion
    101529337 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101529337 (PLCB2)
   04270 Vascular smooth muscle contraction
    101529337 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    101529337 (PLCB2)
   04971 Gastric acid secretion
    101529337 (PLCB2)
   04972 Pancreatic secretion
    101529337 (PLCB2)
   04973 Carbohydrate digestion and absorption
    101529337 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101529337 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    101529337 (PLCB2)
   04725 Cholinergic synapse
    101529337 (PLCB2)
   04728 Dopaminergic synapse
    101529337 (PLCB2)
   04726 Serotonergic synapse
    101529337 (PLCB2)
   04720 Long-term potentiation
    101529337 (PLCB2)
   04730 Long-term depression
    101529337 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    101529337 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    101529337 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    101529337 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101529337 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101529337 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101529337 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101529337 (PLCB2)
   05142 Chagas disease
    101529337 (PLCB2)
   05143 African trypanosomiasis
    101529337 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101529337 (PLCB2)
   05016 Huntington disease
    101529337 (PLCB2)
   05017 Spinocerebellar ataxia
    101529337 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    101529337 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101529337 (PLCB2)
   05415 Diabetic cardiomyopathy
    101529337 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101529337 (PLCB2)
   04934 Cushing syndrome
    101529337 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:opi04131]
    101529337 (PLCB2)
Enzymes [BR:opi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101529337 (PLCB2)
Membrane trafficking [BR:opi04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101529337 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101529337 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 101529337
NCBI-ProteinID: XP_004578489
Position
17:complement(53992924..54008525)
AA seq 1153 aa
MSLLSPVLRPPQVKAYLSQGERFIKWDDETAMASPIILRVDPKGYYLYWTYQSKEMEFLD
VTTIRDTRFGKFAKMPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPLTANAPRITFLDKILVKLRMQLNPEGKIPVKNFFQMFPADRKR
VEAALGACHLPKGKNDAINPEDFPESVFKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPEQVQGLIEKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFAAPPAAPSKEHAG
EAGPPSSPTSEDAGVWVGEEVAELEEEEEVEEEEESLGNLDEEEIKKMQSDEGTAGLEVT
AYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKASDLLSKSSVQFVEYNKRQMS
RIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFM
RRPDKQFNPFSVDRIDVVVATTLAITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTK
LSPNANSINPVWKEEPFIFEKILMPELASLRVAVMEEGGKFLGHRIIPINALNSGYHHLC
LHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFNAHDKKSVKLKEAMTGVP
EKPFSCGSSVAGPVKAPSAPSSNGSAEPRTASLEELRELKGVVKLQKRHEKELRELLRRG
ARRWEELLQQGAAQLAEMGSLGPGGCGARKLGPSKGSRKKRSLPGEETPGALPVEGPDCA
DSLVRELKDRLQLELRREGEEQCQCVRTRREQQAAEQVAKMMELAREKHAAELKTLKETS
EIDTKEMKKKLEAKRLERIQAMTKITTDKMAQERLKREINNSHIQEVVQVIQQMTKNLER
YQEKLEEKQAACLEQIRDMEKQFQQEALAEYEAKMKGLETEVKELVRTWILLEPGQPNEQ
ESRPAQDAEESRL
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgtctctgctcagccctgtcctgcggcccccgcaggtgaaggcctatctgagccaaggc
gaacgctttatcaaatgggatgacgaaacggcaatggcctccccgattatcctccgtgtg
gatcccaagggttactatttatactggacatatcagagtaaggaaatggagtttctcgat
gtcaccaccatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgtgaagtcttcaacatggacttccctgacaaccatttcctgctgaagacgctcact
gtggtgtccggccccgacatggtggacctcaccttccacaactttgtctcctataaggag
aacgtgggcaaggactgggccgaggatgtcctggccttggccaagcacccgctgacagcc
aacgcccctcgcatcacattcctggacaagatcctggtgaagctcagaatgcagctcaac
cctgaggggaagatccccgtgaagaattttttccagatgttccctgctgaccgaaagcgg
gtagaagctgctcttggtgcctgccaccttccgaaaggcaagaacgatgccatcaatcca
gaggacttcccggaatccgtattcaagagtttcctcatgagcctgtgtcctcggccagaa
atagacgagatcttcacttcctaccatgctaaggccaaaccttacatgaccaaggaacac
ctgaccaaattcatcaaccagaaacagcgagattcgcggctcaactccctgctgttccca
cccgcgcggcctgagcaggtgcagggcctcattgaaaagtacgagcccagcgggatcaat
gtgcagagaggccagctttcacccgagggcatggtgtggtttttgtgcgggccagagaac
agtgtgctggctcaggacaagctgttgctgcaccacgatatgacacagcccctgaatcat
tacttcattaactcctcacataacacctacctgacagctggccagttctcgggcctgtcc
tcggctgagatgtaccgccaggtgctgctggctggctgccgctgcgtggagctggactgc
tggaaggggaagccgcccgatgaagagcccatcatcacccatggcttcaccatgaccacg
gatatcttcttcaaggaagcaattgaagctattgcagagagtgcctttaagacctccccc
tatcctgttatcttgtcttttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtactgccggaccatgtttggggacatgctgctcacggagccgctggagaagttc
ccactgaagccaggcatccccctgcccagccctgaggatctccggggcaagatcctcatc
aagaacaagaaaaatcagtttgctgctcctccagcagcgcccagcaaggagcatgctggg
gaggctggtccacccagcagccccaccagcgaagatgctggagtgtgggttggagaggag
gtggctgagctggaagaggaggaagaagtggaggaggaggaggagtcgttgggaaacctg
gacgaagaggagatcaaaaagatgcagtcggatgagggcacagcaggcctggaggtgaca
gcctatgaggagatgtccagcctggtcaattacatccaacctaccaagttcatctctttc
gagttctctgcccagaagaaccgcagttatgtcatctcctccttcaccgagctcaaggct
tctgacctgctctccaagtcctcggtgcagtttgtagagtacaacaagcgccagatgagc
cgcatttaccccaagggcacccgcatggactcttccaactacatgccgcagatgttctgg
aatgccggatgccagatggttgccctcaacttccagactatggacctacccatgcagcag
aacatggcactgtttgagttcaacgggcagagtggctacctcctcaagcatgaattcatg
cgccggccggacaagcagttcaatcccttctcagtggaccgcatcgatgtggtggtggct
accaccctcgctataacggtgatctccgggcagttcctgtcagaacgcagcgtgcgcacc
tatgtggaagtagagttatttggtctccctggggatcccaagaggcgctaccgcaccaag
ctgtcccctaatgccaactccatcaatcctgtctggaaggaggaacctttcatctttgag
aagatcctgatgcctgagctggcctccctcagggtggctgtgatggaggaaggaggcaaa
tttcttggacatcgcatcatacccatcaatgccctaaattctggataccaccacctgtgc
ctgcacagcgagagcaacatgccccttaccatgcctgctctctttgtcttcttggagatg
aaagattacgtacctgacacctgggcagatctcacagtggcccttgccaatcccatcaaa
ttcttcaatgcccatgacaagaagtctgtgaagctcaaggaggccatgacaggtgtgcct
gagaagcccttctcatgtgggagttcagtagctgggccagtcaaggcgccatcagcccct
agcagcaacgggtcagcagagccgcgcaccgccagcctggaggagctgcgggagctgaag
ggcgtcgtgaagctgcagaagaggcacgagaaggagctgcgggagctgctgcggcgaggc
gcacggcgctgggaggagctgctgcaacagggagcggcacagctggcggagatgggctcg
ctggggccggggggctgtggggcccgcaagctcggccccagcaagggctcccgcaaaaag
aggtctttgcctggtgaggagacccccggcgccctaccggtagagggccccgattgtgcg
gactcgcttgtgcgggagctgaaagaccggttgcagctggagctgcgccgagaaggcgag
gagcagtgccagtgtgtccggacgcgcagggaacagcaggcagctgagcaagtagccaag
atgatggagctggccagagagaaacatgccgcggagctgaagaccctcaaggagacctca
gagattgacaccaaagagatgaagaaaaagctggaggccaagaggctggagaggatccag
gccatgaccaagatcaccacagacaagatggcccaagaaaggttgaagagagagatcaac
aactcccacatccaggaagtggtgcaggtcatccagcagatgaccaagaacctggagcgg
taccaggaaaagctggaggagaagcaggccgcctgcctggaacagatccgggatatggaa
aagcagttccaacaggaggcactggcggagtacgaggccaagatgaagggcctggagact
gaggtgaaggagctggtgaggacctggatccttctggagccggggcagcccaacgagcag
gaatcacgcccagcccaggatgccgaggagagccgcctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (7)   
   Pfam (7)   
All databases (14)   

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