KEGG   Pseudomonas aeruginosa PAO1: PA4225
Entry
PA4225            CDS       T00035                                 

Symbol
pchF
Name
(RefSeq) pyochelin synthetase
  KO
K12240  L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]
Organism
pae  Pseudomonas aeruginosa PAO1
Pathway
pae01053  Biosynthesis of siderophore group nonribosomal peptides
Brite
KEGG Orthology (KO) [BR:pae00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01053 Biosynthesis of siderophore group nonribosomal peptides
    PA4225 (pchF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:pae01008]
    PA4225 (pchF)
Enzymes [BR:pae01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.69  L-cysteine---[L-cysteinyl-carrier protein] ligase
     PA4225 (pchF)
Polyketide biosynthesis proteins [BR:pae01008]
 Nonribosomal peptide synthetase (NRPS)
  Nonlinear NRPS
   Pyochelin synthetase
    PA4225 (pchF)
SSDB
Motif
Pfam: AMP-binding Condensation TubC_N Methyltransf_12 PP-binding AMP-binding_C Thioesterase Methyltransf_25 Methyltransf_23 Methyltransf_11 Methyltransf_31 DUF3726 ACP_syn_III HTH_20
Other DBs
NCBI-GeneID: 880083
NCBI-ProteinID: NP_252915
UniProt: Q9HWG4
Position
complement(4731369..4736798)
AA seq 1809 aa
MSLGELLETCRSRRIELWSEAGRLRYRAPQGALDAGLAERLRAEREALLEHLEGGPGWRA
EPDMAHQRFPLTPVQAAYVLGRQAAFDYGGNACQLYAEYDWPADTDPARLEAAWNAMVER
HPMLRAVIEDNAWQRVLPEVPWQRLTVHACAGLDEAAFQAHLERVRERLDHACAALDQWP
VLRPELSIGRDACVLHCSVDFTLVDYASLQLLLGEWRRRYLDPQWTAEPLEATFRDYVGV
EQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRVQPDTRSTRFRHFHARLDEAAWQALGA
RAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRPPLHPQLAQVLGDFTALSLLA
VDSRHGDSFVERARRIGEQMFDDLDHPTFSGVDLLRELARRRGRGADLMPVVFTSGIGSV
QRLLGDGEAPRAPRYMISQTPQVWLDCQVTDQFGGLEIGWDVRLGLFPEGQAEAMFDDFV
GLLRRLAQSPRAWTDGDATEPVEAPPQALPGSARSIAAGFAERALLTPDATAIHDAAGSY
SYRQVAQHASALRRVLEAHGAGRGRRVAVMLPKSAAQLVAVIGILQAGAAYVPVDIRQPP
LRRQAILASAEVVALVCLESDVPDVGCACVAIDRLAADSAWPPPPAAEVAADDLAYVIYT
SGSTGTPKGVMLSHAAVSNTLLDINQRYGVDANDRVLGLAELSFDLSVYDFFGATAAGAQ
VVLPDPARGSDPSHWAELLERHAITLWNSVPAQGQMLIDYLESEPQRHLPGPRCVLWSGD
WIPVSLPTRWWRRWPDSALFSLGGATEAAIWSIEQPIRPQHTELASIPYGRALRGQSVEV
LDARGRRCPPGVRGEIHIGGVGLALGYAGDPQRTAERFVRHPDGRRLYRTGDLGRYLADG
SIEFLGREDDQVKIRGHRIELAELDAALCAHPQVNLAATVVLGETHERSLASFVTLHAPV
EAGEDPRTALDAVRQRAAQALRRDWGSEEGIAAAVAALDRACLASLAAWLAGSGLFASAT
PLDLATLCQRLGIAEARQRLLRHWLRQLEEGGYLRAEGEGWLGCAERPAQSPEDAWTAFA
GCAPAALWPAELVAYLRDSAQSLGEQLAGRISPAALMFPQGSARIAEAMYSQGLHAQALH
EAMAEAIAAIVERQPQRRWRLLELGAGTAAASRTVIARLAPLVQRGAEVDYLFTDVSSYF
LAAARERFADQPWVRFGRFDMNGDLLDQGVAPHSVDILLSSGALNNALDTPALLAGLREL
LSADAWLVIQELTREHNEISVSQSLMMENPRDLRDERRQLFVHTGQWLEWLAAQGGDLAC
GVVPPGSALDLLGYDVLLARCKTDRARLEPAELLAFVEARVPRYMLPAQLRVLERLPVTG
NGKIDRKALTGFARQPQADLRHGVAQAPADELENALLALWREVLDNPSLGVEQDFFGAGG
DSLLIAQLIARLRERLESARRHPFDRLLRWALSQPTPRGLAERLRSAPEEGRGPALAAAR
GVAPAPAGMSRAPLAEGAVALDPLVRLVPGEGVPRVLVHEGLGTLLPYRPLLRALGEGRP
LLGLAVHDSDAYLAIPAEHLNACLGRRYAEALHRAGLREVDLLGYCSGGLVALETAKSLV
QRGVRVRQLDIVSSYRIPYRVDDERLLLFSFAATLGLDTAALGFPAPERLGQAVQAALAQ
TPERLVAEALAGLPGLADLVALRGRVLQAASGSADAVSVERDTLYRLFCHSVRASQAEAP
EPYVGALRLFVPDAGNPLVPRYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQSLS
KPMPEEASR
NT seq 5430 nt   +upstreamnt  +downstreamnt
atgagcctcggcgaactgctggaaacctgccgcagccggcgcatcgaactctggagcgag
gcgggccgcctgcgctatcgcgccccccagggtgccctcgacgccggcctcgccgagcgc
ctgcgggccgagcgcgaggccctgctggaacacctggaaggcggccctggctggcgcgcc
gaacccgacatggcccaccagcgcttcccgctgaccccggtgcaggccgcctacgtgctg
ggccgccaggcggccttcgactacggcggtaacgcctgccagctgtacgccgagtacgac
tggccggccgacaccgatccggcgcgcctggaggcggcctggaacgccatggtcgagcgc
cacccgatgctgcgcgcggtgatcgaggacaacgcctggcagcgcgtgctgcccgaggtg
ccctggcagcggctgaccgtgcatgcctgcgcggggctcgacgaggccgctttccaggcg
cacctggagcgggtccgcgaacgcctcgaccacgcctgcgcggcgctcgaccagtggccg
gtcctgcgccccgagctgagtatcggccgggatgcctgcgtactgcactgctcggtggat
ttcaccctggtcgactacgccagcctgcaattgctgcttggcgaatggcgccgccgctat
ctcgatccgcaatggacggcggaaccgctggaggcgaccttccgcgactatgtcggcgtc
gagcagcgccgacgccagtcgccagcctggcagcgcgaccgcgactggtggctggcgcgt
ctcgacgcgctaccggggcgtcccgacctgccgctgcgggtgcagccggacacccggtcc
acgcgcttccggcacttccacgcgcgcctcgacgaggccgcctggcaggcgctcggcgcg
cgcgccggcgaacacggcctgagcgctgccggcgtggccttggcggccttcgccgagacc
atcggtcgctggagccaggcaccggcgttctgtctcaacctgacggtactcaaccggccg
ccgctgcatccgcagctggcgcaggtgctcggtgacttcaccgcgctcagcctgctggca
gtggacagccgccacggcgacagtttcgtcgagcgtgcccgacgcatcggcgagcagatg
ttcgacgacctcgaccacccgaccttcagcggcgtcgacctgctgcgcgaactggcgcgc
cggcgtggtcgcggcgccgatctgatgccggtggtgttcaccagtggcatcggcagcgtg
cagcgcctgctcggcgatggcgaggcgccgcgcgcgccacgctacatgatcagccagacc
ccgcaggtctggctggactgccaggtcaccgaccagttcggcggcctggagatcggctgg
gacgtacgcctcgggttgttccccgagggccaggcggaagccatgttcgacgacttcgtc
gggctgctccggcgcctggcgcagagcccgcgcgcctggaccgacggcgatgccacggaa
cccgtcgaggcgccgccgcaggcgttgcccggtagtgcccggagcatcgccgccggtttc
gccgagcgtgccctgctgacccccgacgccacggcgatccacgatgccgccggcagctac
agctaccgccaggtcgcccagcacgccagcgccctgcgccgcgtcctggaagcgcacggc
gcgggccgtggccggcgggtcgcggtgatgctgccgaaaagcgccgcgcaattggtcgcg
gtgatcggcatcctccaggccggcgccgcctatgtgccggtggacatccgccagcctccg
ctgcggcgccaggcgatcctcgccagcgccgaagtggtcgcgctggtctgcctggaaagc
gatgtcccggacgtcggctgcgcctgcgtggccatcgaccggctggccgccgacagcgcc
tggccgccaccgcccgcggcggaggtggcggcggacgacctcgcctacgtgatctacacc
tccggctccaccggcacgccaaagggcgtgatgctcagccatgcggcggtgagcaacacg
ctgctcgacatcaaccagcgctacggcgtcgacgccaacgaccgcgtcctcggcctcgcc
gagctgagcttcgacctctcggtctacgacttcttcggcgccaccgcggcgggggcccag
gtggtcctcccggacccggcgcgcggcagcgatccatcgcactgggcggaactgctggaa
cgccacgccatcaccctgtggaactcggtgccggcccaaggccagatgctcatcgattac
ctggagagcgagccgcaacgtcacctgccgggaccgcgctgcgtgctctggtccggtgac
tggattccggtcagcctgccgacccgctggtggcggcgctggccggacagcgcgctgttc
agcctgggcggcgccaccgaggcggcgatctggtcgatcgagcagccgatccgcccgcag
cacaccgagctggccagcatcccttatggccgtgccctgcgcgggcagagcgtggaagtc
ctggatgcccgcgggcggcgctgcccgccgggcgtgcgcggcgagatccatatcggcggg
gtgggcctggcgctcggctacgccggcgatccgcagcgcaccgccgaacgcttcgtccgt
caccccgatggccgtcgcctgtatcgcaccggcgacctcggccgctacctggccgacggc
agcatcgagttcctcggccgcgaggacgaccaggtgaagattcgcggccaccgcatcgaa
ctggccgaactggacgccgcgctgtgcgctcatccgcaggtcaacctggcggccaccgtg
gtgctcggcgagacccacgagcgcagcctggccagcttcgtcaccctgcatgcgccggtg
gaggctggcgaggatccgcgtacggcgctcgacgcggtgcgccagcgggcggcccaggcc
ttgcgccgcgactggggcagcgaggagggcatcgccgcggcggtggccgcactcgaccgt
gcctgcctcgcctcgttggccgcctggctggccggcagcggtctgttcgccagtgcgacg
ccgctggacttagccaccctgtgccagcgcctgggtatcgccgaggcgcgccagcgcctg
ctgcgccactggttgcgccaactggaggagggcggctacctgcgcgccgagggcgagggc
tggctgggctgcgccgagcgtcccgcgcagagtccggaggacgcctggacggcgttcgcc
ggctgcgcgccggcggcgctctggccggccgagctggtcgcctacctgcgtgacagcgcg
caatccctcggcgagcaactggccgggcggatcagcccggcggcgctgatgttcccgcag
ggctcggcgcgcatcgccgaggccatgtacagccagggcctgcatgcccaggcgctgcac
gaggccatggccgaggccatcgccgccatcgtcgagcgccagccgcaacggcgctggcgc
ctgctggagcttggcgccggcaccgccgccgccagccgcacggtgatcgcccggttggcg
ccgctggtgcagcgaggggcggaggtggactacctgttcaccgacgtttccagctacttc
ctcgccgccgcccgcgagcgcttcgccgaccagccgtgggtacgcttcggccgcttcgac
atgaacggcgatcttctcgaccagggcgtggcgccgcactcggtggatatcctgctcagc
tccggggccttgaacaacgcgctggacaccccggcgctgctggccggcctgcgcgagttg
ctgagcgccgacgcctggctggtgatccaggaactgacgcgcgagcacaacgagatcagc
gtcagccagagcctgatgatggaaaacccgcgcgacctccgcgacgagcgccgccaactg
ttcgtccacaccgggcaatggctggagtggctggcggcacagggtggcgacctggcttgt
ggggtggtgccgccgggcagcgctctcgacctgcttggctacgatgtcctgctggctcgc
tgcaagaccgaccgcgcccgcctggagccggccgagctgctggccttcgtcgaagcgcgg
gtgccgcgctacatgctcccggcgcagttgcgcgtgctcgaacgcctgccggtcaccggc
aacggcaagatcgaccgcaaggccctgaccggctttgcccgccagccccaggcggacctt
cggcatggcgtcgcgcaggcaccggccgacgaactggagaatgcgctgctggcactctgg
cgggaggtgctggacaacccgtcgctgggcgtcgagcaagacttcttcggggccggcggc
gactcgctgttgatcgcccagttgatcgcccgtttgcgcgaacgactggaaagcgcccgt
cggcatccgttcgatcgcctgctacgctgggcgctcagccagccgacgccgcgcggcctg
gccgaacgcctgcgcagcgcgccggaagagggccgtgggccagccctggccgcggcgcgc
ggcgtcgccccggcgccggccggcatgtcgcgcgcaccgctcgccgagggcgcggtggcg
ctcgacccgctggtgcgcctggtgcccggcgagggcgtgccgcgggtgctggtccacgaa
ggcctcggcacgctactgccgtaccgcccgctgcttcgcgccctgggtgaggggcggccg
ttgctggggctggccgtgcatgacagcgacgcctacctggcgatccccgccgagcatctc
aacgcctgcctcggccgccgctacgccgaggcgctccatcgcgccgggctacgcgaggtc
gacctgctcggctactgctccggcgggctggtcgccctggagaccgccaagtccctggtc
cagcgcggggtgcgcgtgcgccaactggatatcgtctccagctaccggattccctaccgg
gtggacgacgagcgcctgctgttgttcagcttcgccgcgaccctcggcctggataccgcg
gcgctcggcttccccgcgccggaacgtctcggccaggcggtgcaggcggcgctcgcgcag
acaccggagcgcctggtcgccgaggcgctggcggggctgccgggcctggccgatctcgtc
gccctgcgcggccgcgtgctacaggcggccagcggtagcgccgacgccgtcagcgtcgaa
cgcgacaccctctaccggctgttctgtcactcggtgcgtgccagccaggccgaggcgccg
gagccctacgtcggcgcgctgcggctgttcgtgccggacgccggcaacccattggtgccg
cgctacgccgaggctctggagacccaatggcgggccgccgcgcttggcgcgtgcggcatc
cacgaggtgcccggcgggcacttcgactgcctgggcgaagccctggcgcaatccttgtcg
aaacccatgccagaggaggcgagccgatga

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