KEGG   PATHWAY: ang03420
ang03420                    Pathway                                

Nucleotide excision repair - Aspergillus niger
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Pathway map
ang03420  Nucleotide excision repair

Other DBs
GO: 0006289
Aspergillus niger [GN:ang]
ANI_1_2062064  An07g08490; ATP-dependent DNA helicase [KO:K03657] [EC:]
ANI_1_294154  An17g02100; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:]
ANI_1_2152074  An08g07830; UV-damaged DNA binding protein [KO:K10610]
ANI_1_1244084  An09g02820; DNA repair protein Rad4 [KO:K10838]
ANI_1_2430024  An02g03720; rad4 family protein [KO:K10838]
ANI_1_1194184  An04g07490; WD repeat protein [KO:K10570]
ANI_1_1096124  An14g01060; DNA repair protein Rhp26/Rad26 [KO:K10841]
ANI_1_1776184  An04g03810; RNA polymerase II transcription factor B subunit 3 [KO:K10842]
ANI_1_378154  An17g00250; hypothetical protein [KO:K06634]
ANI_1_704084  An09g05640; DNA repair helicase ercc3 [KO:K10843] [EC:]
ANI_1_992074  An08g07060; DNA repair helicase rad15 [KO:K10844] [EC:]
ANI_1_166084  An09g01660; RNA polymerase II transcription factor B subunit 5 [KO:K10845]
ANI_1_1872184  An04g04810; RNA polymerase II transcription factor [KO:K03141]
ANI_1_1576084  An09g06810; TFIIH basal transcription factor complex p47 subunit [KO:K03142]
ANI_1_400164  An18g03180; transcription factor TFIIH complex subunit [KO:K03143]
ANI_1_86124  An14g00480; TFIIH and nucleotide excision repair factor 3 complexes subunit [KO:K03144]
ANI_1_1212034  An03g02890; single-stranded DNA endonuclease [KO:K10846]
ANI_1_438034  An03g03720; DNA repair protein rad14 [KO:K10847]
ANI_1_2080024  An02g14980; replication factor A protein 1 [KO:K07466]
ANI_1_2138074  An08g07600; possible replication factor-a protein [KO:K10739]
ANI_1_962104  An12g07910; DNA repair protein RAD1 [KO:K10848] [EC:3.1.-.-]
ANI_1_1544184  An04g00580; mating-type switch/DNA repair protein Swi10/Rad10 [KO:K10849]
ANI_1_982134  An15g07150; DNA polymerase delta catalytic subunit [KO:K02327] [EC:]
ANI_1_476184  An04g02280; DNA polymerase delta subunit 2 [KO:K02328]
ANI_1_1296184  An04g08720; hypothetical protein [KO:K03504]
ANI_1_112094  An11g00720; DNA polymerase delta subunit 4 [KO:K03505]
ANI_1_116094  DNA polymerase delta subunit 4 [KO:K03505]
ANI_1_434144  An16g03060; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:]
ANI_1_2054024  An02g14830; DNA polymerase epsilon subunit B [KO:K02325] [EC:]
ANI_1_598024  An02g04290; replication factor C subunit 1 [KO:K10754]
ANI_1_52134  An15g00270; replication factor C subunit 4 [KO:K10755]
ANI_1_1662024  An02g11980; replication factor C subunit 2 [KO:K10755]
ANI_1_604024  An02g04320; replication factor C subunit 5 [KO:K10756]
ANI_1_210144  An16g01580; replication factor C subunit 3 [KO:K10756]
ANI_1_2644024  An02g06890; DNA ligase 3 [KO:K10747] [EC:]
ANI_1_594104  An12g04690; DNA ligase Cdc9 [KO:K10747] [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome] Japanese
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
ang03020  RNA polymerase
ang04120  Ubiquitin mediated proteolysis
KO pathway

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