KEGG   PATHWAY: ang03430
Entry
ang03430                    Pathway                                

Name
Mismatch repair - Aspergillus niger
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
ang03430  Mismatch repair
ang03430

Other DBs
GO: 0006298
Organism
Aspergillus niger [GN:ang]
Gene
ANI_1_2062064  An07g08490; ATP-dependent DNA helicase [KO:K03657] [EC:3.6.4.12]
ANI_1_2322024  An02g02280; DNA mismatch repair protein (Pms1) [KO:K10858]
ANI_1_376164  An18g03030; DNA mismatch repair protein Mlh1 [KO:K08734]
ANI_1_590184  An04g03050; DNA mismatch repair protein Msh6 [KO:K08737]
ANI_1_490144  An16g03520; DNA mismatch repair protein msh-2 [KO:K08735]
ANI_1_150114  An13g01060; DNA mismatch repair protein MSH3 [KO:K08736]
ANI_1_1570184  An04g00870; DNA mismatch repair protein (Mlh3) [KO:K08739]
ANI_1_598024  An02g04290; replication factor C subunit 1 [KO:K10754]
ANI_1_52134  An15g00270; replication factor C subunit 4 [KO:K10755]
ANI_1_1662024  An02g11980; replication factor C subunit 2 [KO:K10755]
ANI_1_604024  An02g04320; replication factor C subunit 5 [KO:K10756]
ANI_1_210144  An16g01580; replication factor C subunit 3 [KO:K10756]
ANI_1_1586144  An16g02590; exonuclease [KO:K10746] [EC:3.1.-.-]
ANI_1_2080024  An02g14980; replication factor A protein 1 [KO:K07466]
ANI_1_2138074  An08g07600; possible replication factor-a protein [KO:K10739]
ANI_1_982134  An15g07150; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
ANI_1_476184  An04g02280; DNA polymerase delta subunit 2 [KO:K02328]
ANI_1_1296184  An04g08720; hypothetical protein [KO:K03504]
ANI_1_112094  An11g00720; DNA polymerase delta subunit 4 [KO:K03505]
ANI_1_116094  DNA polymerase delta subunit 4 [KO:K03505]
ANI_1_2644024  An02g06890; DNA ligase 3 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
ANI_1_594104  An12g04690; DNA ligase Cdc9 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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