KEGG   PATHWAY: ani04138
Entry
ani04138                    Pathway                                

Name
Autophagy - yeast - Aspergillus nidulans
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
ani04138  Autophagy - yeast
ani04138

Other DBs
GO: 0006914
Organism
Aspergillus nidulans [GN:ani]
Gene
AN0182.2  RAS_EMENI RAS-LIKE PROTEIN [KO:K07827]
AN5832.2  hypothetical protein [KO:K07827]
AN6305.2  hypothetical protein [KO:K04345] [EC:2.7.11.11]
AN4717.2  hypothetical protein [KO:K04345] [EC:2.7.11.11]
AN5728.2  hypothetical protein [KO:K21157] [EC:2.7.11.1]
AN1632.2  hypothetical protein [KO:K08269] [EC:2.7.11.1]
AN2076.2  hypothetical protein [KO:K08331]
AN6360.2  hypothetical protein [KO:K08329]
AN3734.2  hypothetical protein [KO:K17907]
AN5491.2  hypothetical protein [KO:K17906]
AN0127.2  hypothetical protein [KO:K17908]
AN0861.2  hypothetical protein [KO:K21141]
AN2887.2  hypothetical protein [KO:K08330]
AN0673.2  hypothetical protein [KO:K17260]
AN0140.2  ARP3_NEUCR Actin-like protein 3 [KO:K18584]
AN5778.2  hypothetical protein [KO:K05757]
AN0306.2  hypothetical protein [KO:K05758]
AN8065.2  hypothetical protein [KO:K05756]
AN8698.2  hypothetical protein [KO:K05755]
AN4919.2  hypothetical protein [KO:K05754]
AN4238.2  hypothetical protein [KO:K19800] [EC:2.7.11.1]
AN5666.2  hypothetical protein [KO:K04464] [EC:2.7.11.24]
AN3728.2  hypothetical protein [KO:K00654] [EC:2.3.1.50]
AN1102.2  hypothetical protein [KO:K00654] [EC:2.3.1.50]
AN4639.2  hypothetical protein [KO:K07204]
AN5982.2  hypothetical protein [KO:K07203] [EC:2.7.11.1]
AN1335.2  hypothetical protein [KO:K08266]
AN0120.2  hypothetical protein [KO:K17606]
AN6391.2  P2A1_EMENI Serine/threonine protein phosphatase PP2A catalytic subunit (Protein phosphatase 2a) [KO:K04382] [EC:3.1.3.16]
AN5814.2  hypothetical protein [KO:K17607]
AN7572.2  hypothetical protein [KO:K12767] [EC:2.7.11.1]
AN2246.2  hypothetical protein [KO:K16196] [EC:2.7.11.1]
AN3156.2  hypothetical protein [KO:K03237]
AN1867.2  hypothetical protein [KO:K06655] [EC:2.7.11.22]
AN9500.2  hypothetical protein [KO:K21197]
AN5131.2  hypothetical protein [KO:K08341]
AN0576.2  hypothetical protein [KO:K08333] [EC:2.7.11.1]
AN4709.2  hypothetical protein [KO:K00914] [EC:2.7.1.137]
AN0156.2  hypothetical protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]
AN6880.2  hypothetical protein [KO:K07756] [EC:2.7.4.21]
AN1760.2  hypothetical protein [KO:K08336]
AN7428.2  hypothetical protein [KO:K08337]
AN5174.2  hypothetical protein [KO:K08339]
AN7718.2  hypothetical protein [KO:K08343]
AN3470.2  hypothetical protein [KO:K08342] [EC:3.4.22.-]
AN4551.2  hypothetical protein [KO:K08502]
AN1973.2  hypothetical protein [KO:K08493]
AN8488.2  hypothetical protein [KO:K08516]
AN3098.2  hypothetical protein [KO:K06027] [EC:3.6.4.6]
AN6267.2  hypothetical protein [KO:K15296]
AN0089.2  RAB7_NEUCR Probable Ras-related protein Rab7 [KO:K07897]
AN2093.2  hypothetical protein [KO:K20195]
AN2461.2  hypothetical protein [KO:K20179]
AN6911.2  hypothetical protein [KO:K20180]
AN2266.2  hypothetical protein [KO:K20181]
AN2418.2  hypothetical protein [KO:K20182]
AN0763.2  hypothetical protein [KO:K20177]
AN0244.2  hypothetical protein [KO:K20178]
AN6720.2  hypothetical protein [KO:K20183]
AN4876.2  hypothetical protein [KO:K20184]
AN6531.2  hypothetical protein [KO:K12479]
AN2903.2  hypothetical protein [KO:K01381] [EC:3.4.23.25]
AN0238.2  hypothetical protein [KO:K01336] [EC:3.4.21.48]
AN5919.2  hypothetical protein [KO:K17900] [EC:3.1.1.3]
AN7591.2  hypothetical protein [KO:K06902]
AN7437.2  hypothetical protein [KO:K06902]
AN4477.2  hypothetical protein [KO:K14209]
AN7777.2  hypothetical protein [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   

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