KEGG   PATHWAY: bsu00290
Entry
bsu00290                    Pathway                                

Name
Valine, leucine and isoleucine biosynthesis - Bacillus subtilis subsp. subtilis 168
Class
Metabolism; Amino acid metabolism
Pathway map
bsu00290  Valine, leucine and isoleucine biosynthesis
bsu00290

Module
bsu_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bsu00290]
bsu_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bsu00290]
bsu_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bsu00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
Gene
BSU21770  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSU28260  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BSU28250  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BSU28270  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
BSU36010  alsS; acetolactate synthase [KO:K01652] [EC:2.2.1.6]
BSU28310  ilvB; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BSU28300  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
BSU28290  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
BSU21870  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BSU38550  ywaA; branched-chain-amino acid aminotransferase 2 [KO:K00826] [EC:2.6.1.42]
BSU02390  ybgE; branched-chain-amino acid transaminase 1 [KO:K00826] [EC:2.6.1.42]
BSU24080  bcd; leucine dehydrogenase [KO:K00263] [EC:1.4.1.9]
BSU28280  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
bsu00260  Glycine, serine and threonine metabolism
bsu00280  Valine, leucine and isoleucine degradation
bsu00620  Pyruvate metabolism
KO pathway
ko00290   

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