KEGG   PATHWAY: cqu03410
Entry
cqu03410                    Pathway                                
Name
Base excision repair - Culex quinquefasciatus (southern house mosquito)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
cqu03410  Base excision repair
cqu03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ007194  N-glycosylase/DNA lyase [KO:K03660] [EC:3.2.2.- 4.2.99.18]
CpipJ_CPIJ016010  endonuclease iii [KO:K10773] [EC:4.2.99.18]
CpipJ_CPIJ004000  endonuclease iii [KO:K10773] [EC:4.2.99.18]
CpipJ_CPIJ002767  single-strand selective monofunctional uracil DNA glycosylase [KO:K10800] [EC:3.2.2.-]
CpipJ_CPIJ012006  conserved hypothetical protein [KO:K10771] [EC:4.2.99.18]
CpipJ_CPIJ014043  conserved hypothetical protein [KO:K10802]
CpipJ_CPIJ012852  conserved hypothetical protein [KO:K10803]
CpipJ_CPIJ011204  DNA-repair protein XRCC1 [KO:K10803]
CpipJ_CPIJ020141  conserved hypothetical protein [KO:K10803]
CpipJ_CPIJ003295  conserved hypothetical protein [KO:K10803]
CpipJ_CPIJ009046  proliferating cell nuclear antigen [KO:K04802]
CpipJ_CPIJ018287  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
CpipJ_CPIJ010026  DNA polymerase delta small subunit [KO:K02328]
CpipJ_CPIJ012084  conserved hypothetical protein [KO:K03504]
CpipJ_CPIJ008666  DNA polymerase epsilon [KO:K02324] [EC:2.7.7.7]
CpipJ_CPIJ008667  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
CpipJ_CPIJ016568  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
CpipJ_CPIJ020000  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
CpipJ_CPIJ010897  DNA polymerase epsilon subunit 4 [KO:K03506] [EC:2.7.7.7]
CpipJ_CPIJ009862  conserved hypothetical protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
CpipJ_CPIJ015371  conserved hypothetical protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
CpipJ_CPIJ003597  conserved hypothetical protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
CpipJ_CPIJ012304  poly [KO:K24070] [EC:2.4.2.30]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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