KEGG   PATHWAY: cqu03420
cqu03420                    Pathway                                
Nucleotide excision repair - Culex quinquefasciatus (southern house mosquito)
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Pathway map
cqu03420  Nucleotide excision repair

Other DBs
GO: 0006289
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
CpipJ_CPIJ012886  RING-box protein 1A [KO:K03868] [EC:]
CpipJ_CPIJ010574  cullin [KO:K10609]
CpipJ_CPIJ013742  conserved hypothetical protein [KO:K10610]
CpipJ_CPIJ015737  DNA repair protein xp-c / rad4 [KO:K10838]
CpipJ_CPIJ003593  DNA repair protein xp-c / rad4 [KO:K10838]
CpipJ_CPIJ003591  DNA repair protein xp-c / rad4 [KO:K10838]
CpipJ_CPIJ003592  DNA-repair protein complementing XP-C cells [KO:K10838]
CpipJ_CPIJ018296  cak1 [KO:K02202] [EC:]
CpipJ_CPIJ001565  CDK-activating kinase assembly factor MAT1 [KO:K10842]
CpipJ_CPIJ004855  cyclin-H [KO:K06634]
CpipJ_CPIJ006481  TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:]
CpipJ_CPIJ016774  TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:]
CpipJ_CPIJ018703  TFIIH basal transcription factor complex helicase subunit [KO:K10844] [EC:]
CpipJ_CPIJ014629  conserved hypothetical protein [KO:K10845]
CpipJ_CPIJ015824  TFIIH basal transcription factor complex subunit 1 [KO:K03141]
CpipJ_CPIJ004242  TFIIH basal transcription factor complex p44 subunit [KO:K03142]
CpipJ_CPIJ004241  btf [KO:K03142]
CpipJ_CPIJ000358  TFIIH basal transcription factor complex p34 subunit [KO:K03143]
CpipJ_CPIJ005256  TFIIH basal transcription factor complex p52 subunit [KO:K03144]
CpipJ_CPIJ004184  DNA-repair protein complementing XP-G cells [KO:K10846]
CpipJ_CPIJ006890  DNA-repair protein complementing XP-A cells [KO:K10847]
CpipJ_CPIJ002381  replication protein A 70 kDa DNA-binding subunit [KO:K07466]
CpipJ_CPIJ006691  insect replication protein a [KO:K10739]
CpipJ_CPIJ006417  insect replication protein a [KO:K10739]
CpipJ_CPIJ003130  replication factor A, 14kD-subunit [KO:K10740]
CpipJ_CPIJ004313  mei-9 [KO:K10848] [EC:3.1.-.-]
CpipJ_CPIJ013903  DNA excision repair protein ERCC-1 [KO:K10849]
CpipJ_CPIJ018287  DNA polymerase delta catalytic subunit [KO:K02327] [EC:]
CpipJ_CPIJ010026  DNA polymerase delta small subunit [KO:K02328]
CpipJ_CPIJ012084  conserved hypothetical protein [KO:K03504]
CpipJ_CPIJ008666  DNA polymerase epsilon [KO:K02324] [EC:]
CpipJ_CPIJ008667  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:]
CpipJ_CPIJ016568  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:]
CpipJ_CPIJ020000  DNA polymerase epsilon subunit 3 [KO:K02326] [EC:]
CpipJ_CPIJ010897  DNA polymerase epsilon subunit 4 [KO:K03506] [EC:]
CpipJ_CPIJ009046  proliferating cell nuclear antigen [KO:K04802]
CpipJ_CPIJ017892  replication factor C large subunit [KO:K10754]
CpipJ_CPIJ001399  replication factor C subunit 4 [KO:K10755]
CpipJ_CPIJ000302  replication factor C subunit 2 [KO:K10755]
CpipJ_CPIJ001914  replication factor C subunit 3 [KO:K10756]
CpipJ_CPIJ000126  replication factor C 38kD subunit [KO:K10756]
CpipJ_CPIJ014481  replication factor C subunit 3 [KO:K10756]
CpipJ_CPIJ009862  conserved hypothetical protein [KO:K10747] [EC:]
CpipJ_CPIJ015371  conserved hypothetical protein [KO:K10747] [EC:]
CpipJ_CPIJ003597  conserved hypothetical protein [KO:K10747] [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair]
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome]
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases]
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
cqu03020  RNA polymerase
cqu04120  Ubiquitin mediated proteolysis
KO pathway

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