KEGG   PATHWAY: cqu03460
Entry
cqu03460                    Pathway                                
Name
Fanconi anemia pathway - Culex quinquefasciatus (southern house mosquito)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
cqu03460  Fanconi anemia pathway
cqu03460

Other DBs
GO: 0043240
Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ002521  esr1 protein [KO:K06640] [EC:2.7.11.1]
CpipJ_CPIJ020191  conserved hypothetical protein [KO:K10896]
CpipJ_CPIJ001067  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
CpipJ_CPIJ014111  conserved hypothetical protein [KO:K15361]
CpipJ_CPIJ014662  ubiquitin specific protease [KO:K11832] [EC:3.4.19.12]
CpipJ_CPIJ000904  conserved hypothetical protein [KO:K10895]
CpipJ_CPIJ012893  conserved hypothetical protein [KO:K08775]
CpipJ_CPIJ018012  RAD51C protein [KO:K10870]
CpipJ_CPIJ001341  RAD51C protein [KO:K10870]
CpipJ_CPIJ003679  DNA repair protein RAD51 [KO:K04482]
CpipJ_CPIJ016932  DNA mismatch repair protein pms1 [KO:K10858]
CpipJ_CPIJ007351  terminal deoxycytidyl transferase rev1 [KO:K03515] [EC:2.7.7.-]
CpipJ_CPIJ013042  DNA polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
CpipJ_CPIJ013041  DNA polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
CpipJ_CPIJ003345  DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
CpipJ_CPIJ018238  DNA polymerase IV [KO:K03510] [EC:2.7.7.7]
CpipJ_CPIJ004237  conserved hypothetical protein [KO:K10990]
CpipJ_CPIJ019872  conserved hypothetical protein [KO:K10990]
CpipJ_CPIJ006288  DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
CpipJ_CPIJ009756  DNA topoisomerase 3-beta [KO:K03165] [EC:5.6.2.1]
CpipJ_CPIJ007633  ATP-dependent DNA helicase hus2 [KO:K10901] [EC:5.6.2.4]
CpipJ_CPIJ002381  replication protein A 70 kDa DNA-binding subunit [KO:K07466]
CpipJ_CPIJ006691  insect replication protein a [KO:K10739]
CpipJ_CPIJ006417  insect replication protein a [KO:K10739]
CpipJ_CPIJ003130  replication factor A, 14kD-subunit [KO:K10740]
CpipJ_CPIJ020282  crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
CpipJ_CPIJ000871  crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
CpipJ_CPIJ003895  conserved hypothetical protein [KO:K10882] [EC:3.1.22.-]
CpipJ_CPIJ004313  mei-9 [KO:K10848] [EC:3.1.-.-]
CpipJ_CPIJ013903  DNA excision repair protein ERCC-1 [KO:K10849]
CpipJ_CPIJ013689  conserved hypothetical protein [KO:K15078] [EC:3.6.1.-]
CpipJ_CPIJ013688  conserved hypothetical protein [KO:K15078] [EC:3.6.1.-]
Reference
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
cqu03430  Mismatch repair
cqu03440  Homologous recombination
KO pathway
ko03460   

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