KEGG   PATHWAY: ddi03410
Entry
ddi03410                    Pathway                                

Name
Base excision repair - Dictyostelium discoideum (cellular slime mold)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
ddi03410  Base excision repair
ddi03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Dictyostelium discoideum (cellular slime mold) [GN:ddi]
Gene
DDB_G0292618  ogg1; 8-oxoguanine DNA-glycosylase [KO:K03660] [EC:3.2.2.- 4.2.99.18]
DDB_G0277247  apnB; hypothetical protein [KO:K10773] [EC:4.2.99.18]
DDB_G0271050  magA; DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
DDB_G0277877  uglA; uracil glycosylase [KO:K03648] [EC:3.2.2.27]
DDB_G0273013  uglB; uracil glycosylase [KO:K03648] [EC:3.2.2.27]
DDB_G0270764  MYH; A/G-specific adenine DNA glycosylase [KO:K03575] [EC:3.2.2.31]
DDB_G0277701  apeA; hypothetical protein [KO:K10771] [EC:4.2.99.18]
DDB_G0279923  apnA; apurinic/apyrimidinic endonuclease [KO:K10771] [EC:4.2.99.18]
DDB_G0267464  polA; 3'-5' exonuclease domain-containing protein [KO:K02335] [EC:2.7.7.7]
DDB_G0284713  polB; DNA polymerase X family protein [KO:K02330] [EC:2.7.7.7 4.2.99.-]
DDB_G0284739  gxcFF; IQ calmodulin-binding domain-containing protein [KO:K02330] [EC:2.7.7.7 4.2.99.-]
DDB_G0275653  xrcc1; BRCT domain-containing protein [KO:K10803]
DDB_G0287607  pcna; proliferating cell nuclear antigen [KO:K04802]
DDB_G0285381  polD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
DDB_G0281641  polD2; DNA polymerase delta subunit 2 [KO:K02328]
DDB_G0294609  hypothetical protein [KO:K03504]
DDB_G0283189  hypothetical protein [KO:K02324] [EC:2.7.7.7]
DDB_G0278367  hypothetical protein [KO:K02325] [EC:2.7.7.7]
DDB_G0272222  ybl1; DNA polymerase epsilon p17 subunit 3 [KO:K02326] [EC:2.7.7.7]
DDB_G0272740  hypothetical protein [KO:K03506] [EC:2.7.7.7]
DDB_G0274493  lig1; DNA ligase I [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
DDB_G0283857  lig3; BRCT domain-containing protein [KO:K10776] [EC:6.5.1.1]
DDB_G0278741  adprt1A; NAD+ ADP-ribosyltransferase [KO:K24070] [EC:2.4.2.30]
DDB_G0292820  adprt2; NAD+ ADP-ribosyltransferase [KO:K10798] [EC:2.4.2.30]
DDB_G0286613  14-3-3 family protein [KO:K10798] [EC:2.4.2.30]
DDB_G0267468  adprt4; BRCT domain-containing protein [KO:K10798] [EC:2.4.2.30]
DDB_G0279195  adprt1B; NAD+ ADP-ribosyltransferase [KO:K10798] [EC:2.4.2.30]
DDB_G0284987  repG; flap structure specific endonuclease 1 [KO:K04799] [EC:3.-.-.-]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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