KEGG   PATHWAY: ddi03440
Entry
ddi03440                    Pathway                                

Name
Homologous recombination - Dictyostelium discoideum (cellular slime mold)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ddi03440  Homologous recombination
ddi03440

Other DBs
GO: 0000724
Organism
Dictyostelium discoideum (cellular slime mold) [GN:ddi]
Gene
DDB_G0267464  polA; 3'-5' exonuclease domain-containing protein [KO:K02335] [EC:2.7.7.7]
DDB_G0292786  rad50; DNA recombination/repair protein [KO:K10866] [EC:3.6.-.-]
DDB_G0293546  mre11; 3'-5' exonuclease [KO:K10865]
DDB_G0291466  hypothetical protein [KO:K20773] [EC:3.1.-.-]
DDB_G0286621  BRIP1; DEAD/DEAH box helicase [KO:K15362] [EC:3.6.4.12]
DDB_G0279167  cut5; BRCT domain-containing protein [KO:K10728]
DDB_G0293414  hypothetical protein [KO:K08775]
DDB_G0287633  DSS1/SEM1 family protein [KO:K10881]
DDB_G0289513  rfa1; OB fold-containing protein, nucleic acid binding [KO:K07466]
DDB_G0279209  hypothetical protein [KO:K07466]
DDB_G0273611  hypothetical protein [KO:K04482]
DDB_G0273139  hypothetical protein [KO:K04482]
DDB_G0287069  hypothetical protein [KO:K10873]
DDB_G0269406  hypothetical protein [KO:K10873]
DDB_G0284507  hypothetical protein [KO:K10870]
DDB_G0285287  hypothetical protein [KO:K10871]
DDB_G0290297  xrcc2; AAA ATPase domain-containing protein [KO:K10879]
DDB_G0282997  rad54; CHR group protein [KO:K10875] [EC:3.6.4.-]
DDB_G0285117  rad54b; CHR group protein [KO:K10877] [EC:3.6.4.-]
DDB_G0285381  polD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
DDB_G0281641  polD2; DNA polymerase delta subunit 2 [KO:K02328]
DDB_G0294609  hypothetical protein [KO:K03504]
DDB_G0292130  blm; ATP-dependent DNA helicase RecQ family protein [KO:K10901] [EC:3.6.4.12]
DDB_G0272384  ATP-dependent DNA helicase RecQ family protein [KO:K10901] [EC:3.6.4.12]
DDB_G0275257  top3; DNA topoisomerase III [KO:K03165] [EC:5.6.2.1]
DDB_G0276519  mus81; crossover junction endonuclease [KO:K08991] [EC:3.1.22.-]
DDB_G0284175  hypothetical protein [KO:K08991] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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