KEGG   PATHWAY: ko04971
Entry
ko04971                     Pathway                                

Name
Gastric acid secretion
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
Pathway map
ko04971  Gastric acid secretion
ko04971

Other DBs
GO: 0001696
Orthology
K04131  muscarinic acetylcholine receptor M3
K13768  gastrin
K04195  cholecystokinin B receptor
K04634  guanine nucleotide-binding protein G(q) subunit alpha
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K19662  classical protein kinase C beta type [EC:2.7.11.13]
K19663  classical protein kinase C gamma type [EC:2.7.11.13]
K08007  villin 2 (ezrin)
K05692  actin beta/gamma 1
K04958  inositol 1,4,5-triphosphate receptor type 1
K04959  inositol 1,4,5-triphosphate receptor type 2
K04960  inositol 1,4,5-triphosphate receptor type 3
K02183  calmodulin
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K00907  myosin-light-chain kinase [EC:2.7.11.18]
K04150  histamine receptor H2
K04632  guanine nucleotide-binding protein G(s) subunit alpha
K08041  adenylate cyclase 1 [EC:4.6.1.1]
K08042  adenylate cyclase 2 [EC:4.6.1.1]
K08043  adenylate cyclase 3 [EC:4.6.1.1]
K08044  adenylate cyclase 4 [EC:4.6.1.1]
K08045  adenylate cyclase 5 [EC:4.6.1.1]
K08046  adenylate cyclase 6 [EC:4.6.1.1]
K08047  adenylate cyclase 7 [EC:4.6.1.1]
K08048  adenylate cyclase 8 [EC:4.6.1.1]
K08049  adenylate cyclase 9 [EC:4.6.1.1]
K05237  somatostatin
K04218  somatostatin receptor 2
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K04345  protein kinase A [EC:2.7.11.11]
K01542  H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
K01543  H+/K+-exchanging ATPase subunit beta [EC:7.2.2.19]
K04896  potassium voltage-gated channel Isk-related subfamily E member 2
K04926  potassium voltage-gated channel KQT-like subfamily member 1
K04995  potassium inwardly-rectifying channel subfamily J member 1
K04996  potassium inwardly-rectifying channel subfamily J member 2
K05003  potassium inwardly-rectifying channel subfamily J member 10
K05008  potassium inwardly-rectifying channel subfamily J member 15
K05009  potassium inwardly-rectifying channel subfamily J member 16
K05031  cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
K04913  potassium channel subfamily K member 2
K04920  potassium channel subfamily K member 10
K01539  sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
K01540  sodium/potassium-transporting ATPase subunit beta
K05742  solute carrier family 9 (sodium/hydrogen exchanger), member 1
K13961  solute carrier family 9 (sodium/hydrogen exchanger), member 4
K18245  carbonic anhydrase 2 [EC:4.2.1.1]
K13962  solute carrier family 26 (anion exchange transporter), member 7
K13855  solute carrier family 4 (anion exchanger), member 2
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00388  Histamine
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
Reference
  Authors
Schubert ML, Peura DA
  Title
Control of gastric acid secretion in health and disease.
  Journal
Gastroenterology 134:1842-60 (2008)
DOI:10.1053/j.gastro.2008.05.021
Reference
PMID:9307437
  Authors
Urushidani T, Forte JG
  Title
Signal transduction and activation of acid secretion in the parietal cell.
  Journal
J Membr Biol 159:99-111 (1997)
DOI:10.1007/s002329900274
Reference
  Authors
Yao X, Forte JG
  Title
Cell biology of acid secretion by the parietal cell.
  Journal
Annu Rev Physiol 65:103-31 (2003)
DOI:10.1146/annurev.physiol.65.072302.114200
Reference
  Authors
Heitzmann D, Warth R
  Title
No potassium, no acid: K+ channels and gastric acid secretion.
  Journal
Physiology (Bethesda) 22:335-41 (2007)
DOI:10.1152/physiol.00016.2007
Reference
  Authors
Kopic S, Murek M, Geibel JP
  Title
Revisiting the parietal cell.
  Journal
Am J Physiol Cell Physiol 298:C1-C10 (2010)
DOI:10.1152/ajpcell.00478.2009
Reference
  Authors
Schubert ML
  Title
Gastric secretion.
  Journal
Curr Opin Gastroenterol 20:519-25 (2004)
DOI:10.1097/00001574-200411000-00003
Reference
  Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
  Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
  Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
  Authors
Forte JG, Zhu L
  Title
Apical recycling of the gastric parietal cell H,K-ATPase.
  Journal
Annu Rev Physiol 72:273-96 (2010)
DOI:10.1146/annurev-physiol-021909-135744
Reference
  Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
  Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
  Journal
Cell Signal 20:590-601 (2008)
DOI:10.1016/j.cellsig.2007.10.020
Reference
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
  Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
  Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
  Journal
J Physiol 561:547-57 (2004)
DOI:10.1113/jphysiol.2004.075168
Reference
  Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
  Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
  Journal
Acta Physiol (Oxf) 201:3-20 (2011)
DOI:10.1111/j.1748-1716.2010.02107.x
Related
pathway
ko04020  Calcium signaling pathway
ko04530  Tight junction
ko04974  Protein digestion and absorption

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