KEGG   PATHWAY: loa03018
Entry
loa03018                    Pathway                                

Name
RNA degradation - Loa loa (eye worm)
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
loa03018  RNA degradation
loa03018

Other DBs
GO: 0006401
Organism
Loa loa (eye worm) [GN:loa]
Gene
LOAG_09879  hypothetical protein [KO:K12584] [EC:3.6.1.59]
LOAG_02001  hypothetical protein [KO:K07573]
LOAG_00357  Rrp4-PA [KO:K03679]
LOAG_17979  hypothetical protein [KO:K03681]
LOAG_12866  hypothetical protein [KO:K12586]
LOAG_05308  hypothetical protein [KO:K12587]
LOAG_02842  3' exoribonuclease [KO:K12589]
LOAG_00358  EXOSome component family member [KO:K11600]
LOAG_03684  hypothetical protein [KO:K12590]
LOAG_07104  hypothetical protein [KO:K03678]
LOAG_00677  3'-5' exonuclease [KO:K12591] [EC:3.1.13.-]
LOAG_10180  nuclear DNA-binding protein C1D [KO:K12592]
LOAG_01694  hypothetical protein [KO:K12593]
LOAG_05671  PAP/25A associated domain-containing protein [KO:K03514] [EC:2.7.7.19]
LOAG_06429  hypothetical protein [KO:K12598] [EC:3.6.4.13]
LOAG_18173  hypothetical protein [KO:K12599] [EC:3.6.4.-]
LOAG_01377  hypothetical protein [KO:K12602]
LOAG_02052  CCR4-NOT transcription complex subunit 6 family protein [KO:K12603] [EC:3.1.13.4]
LOAG_17788  CCR4-Not complex component [KO:K12604]
LOAG_09579  NOT2/NOT3/NOT5 family protein [KO:K12605]
LOAG_16933  CCR4-NOT transcription complex subunit 2 [KO:K12605]
LOAG_18631  Not1 domain-containing protein [KO:K12580]
LOAG_18762  Cnot4-prov protein [KO:K10643] [EC:2.3.2.27]
LOAG_04270  CCR4-NOT transcription complex subunit 7 [KO:K12581]
LOAG_17796  cell differentiation protein RCD1 [KO:K12606]
LOAG_09500  hypothetical protein [KO:K14443]
LOAG_08799  hypothetical protein [KO:K14443]
LOAG_01058  hypothetical protein [KO:K13126]
LOAG_00636  hypothetical protein [KO:K12571] [EC:3.1.13.4]
LOAG_00323  PAB-dependent Poly(A) specific ribonuclease subunit [KO:K12572]
LOAG_07386  hypothetical protein [KO:K12611] [EC:3.-.-.-]
LOAG_18465  mRNA-decapping enzyme 2 [KO:K12613] [EC:3.6.1.62]
LOAG_02698  ATP-dependent RNA helicase cgh-1 [KO:K12614] [EC:3.6.4.13]
LOAG_06065  hypothetical protein [KO:K12617]
LOAG_09226  hypothetical protein [KO:K12618] [EC:3.1.13.-]
LOAG_08792  U6 snRNA-associated Sm-family protein LSm [KO:K12620]
LOAG_10075  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
LOAG_17508  hypothetical protein [KO:K12622]
LOAG_09541  hypothetical protein [KO:K12623]
LOAG_03146  hypothetical protein [KO:K12624]
LOAG_05763  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
LOAG_01816  hypothetical protein [KO:K12626]
LOAG_00762  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
LOAG_00912  enolase [KO:K01689] [EC:4.2.1.11]
LOAG_14155  enolase [KO:K01689] [EC:4.2.1.11]
LOAG_18896  3' exoribonuclease family [KO:K00962] [EC:2.7.7.8]
LOAG_00771  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
LOAG_06199  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
LOAG_00014  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
LOAG_16336  chaperone DnaK [KO:K04043]
LOAG_17523  chaperonin Hsp-60 [KO:K04077]
Reference
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
DOI:10.1016/j.cell.2009.01.019
Reference
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
DOI:10.1111/j.1365-2958.2006.05331.x
Reference
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
DOI:10.1016/S0074-7696(06)51005-8
Reference
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
DOI:10.1038/sj.embor.7400961
Reference
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
DOI:10.1146/annurev.micro.61.080706.093440
Reference
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
DOI:10.1016/j.tibs.2006.05.005
Reference
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
DOI:10.1016/j.mib.2007.05.008
Related
pathway
loa03015  mRNA surveillance pathway
KO pathway
ko03018   

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