KEGG   PATHWAY: mcf04640
Entry
mcf04640                    Pathway                                

Name
Hematopoietic cell lineage - Macaca fascicularis (crab-eating macaque)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
mcf04640  Hematopoietic cell lineage
mcf04640

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102136326  KITLG; KIT ligand [KO:K05461]
102135001  IL7; interleukin 7 [KO:K05431]
107130068  IL4; interleukin 4 [KO:K05430]
102118747  CSF2; colony stimulating factor 2 [KO:K05427]
102125470  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102125522  IL5; interleukin 5 [KO:K05428]
102123087  CSF3; colony stimulating factor 3 [KO:K05423]
102118362  IL3; interleukin 3 [KO:K04736]
102138971  IL6; interleukin 6 [KO:K05405]
102128313  IL11; interleukin-11 [KO:K05417]
102118349  interleukin-11 [KO:K05417]
101926546  IL1A; interleukin 1 alpha [KO:K04383]
102119749  IL1B; interleukin 1 beta [KO:K04519]
102139631  TNF; tumor necrosis factor [KO:K03156]
102141631  CSF1; colony stimulating factor 1 [KO:K05453]
101925524  EPO; erythropoietin [KO:K05437]
102144240  THPO; thrombopoietin [KO:K06854]
101866926  CD34; CD34 molecule [KO:K06474]
102144988  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102140598  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
102136468  DPB1; HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
102137481  Mafa-DOA; HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102140649  Mafa-DMB; HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102139994  Mafa-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102145413  Mafa-DOB; HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102141962  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
102141582  Mafa-DRB; HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
102132662  Mafa-DQA; HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
102140782  Mafa-DRB; HLA class II histocompatibility antigen, DRB1-16 beta chain-like [KO:K06752]
102144414  Mafa-DRB; HLA class II histocompatibility antigen, DRB1-13 beta chain-like [KO:K06752]
102144039  DRA; mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102136862  Mafa-DPA; HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
102133044  DQB1; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
102141176  Mafa-DQA; HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
102144782  DQB1; HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102142740  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
101867504  CD44; CD44 molecule (Indian blood group) [KO:K06256]
102137242  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102123605  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
102143679  IL7R; interleukin 7 receptor [KO:K05072]
102136007  TFRC; transferrin receptor [KO:K06503]
102126394  CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102124399  CD7; CD7 molecule [KO:K06457]
102120798  CD2; CD2 molecule [KO:K06449]
102136514  CD5; CD5 molecule [KO:K06455]
102139678  CD1E; CD1e molecule [KO:K06448]
102141080  CD1B; CD1b molecule [KO:K06448]
102142140  CD1D; CD1d molecule [KO:K06448]
102127773  CD1A; CD1a molecule [KO:K06448]
102126397  CD1C; CD1c molecule [KO:K06448]
101864991  CD4; CD4 molecule [KO:K06454]
102124337  CD8A; CD8a molecule [KO:K06458]
102122433  CD8B; CD8b molecule [KO:K06459]
102133701  CD3D; CD3d molecule [KO:K06450]
102133065  CD3E; CD3e molecule [KO:K06451]
102134381  CD3G; CD3g molecule [KO:K06452]
101925772  MME; membrane metalloendopeptidase [KO:K01389] [EC:3.4.24.11]
101866748  CD9; CD9 molecule [KO:K06460]
102145514  CD19; CD19 molecule [KO:K06465]
102130968  CD22; CD22 molecule [KO:K06467]
101867055  CD24; CD24 molecule [KO:K06469]
102118491  MS4A1; membrane spanning 4-domains A1 [KO:K06466]
102145559  CR2; complement C3d receptor 2 [KO:K04012]
102117577  CD37; CD37 molecule [KO:K06475]
102118733  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102124047  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102136084  uncharacterized LOC102136084 [KO:K06856]
107128638  uncharacterized LOC107128638 [KO:K06856]
102136483  uncharacterized LOC102136483 [KO:K06856]
102141453  uncharacterized LOC102141453 [KO:K06856]
102140263  uncharacterized LOC102140263 [KO:K06856]
102137633  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102128954  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102135686  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102139130  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102136874  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102127638  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102132406  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102124737  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102122532  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102129333  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102125506  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102117108  FCER2; Fc fragment of IgE receptor II [KO:K06468]
102117401  CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]
102116805  CR1L; complement C3b/C4b receptor 1 like [KO:K04011]
102139775  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
102138639  interleukin-3 receptor subunit alpha-like [KO:K04737]
102117580  CD33; CD33 molecule [KO:K06473]
102133649  IL4R; interleukin 4 receptor [KO:K05071]
102116430  IL6R; interleukin 6 receptor [KO:K05055]
102147198  FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64) [KO:K06498]
102124214  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102115663  ANPEP; alanyl aminopeptidase, membrane [KO:K11140] [EC:3.4.11.2]
101866035  ITGAM; integrin subunit alpha M [KO:K06461]
102129342  CD14; CD14 molecule [KO:K04391]
102136616  IL9R; interleukin 9 receptor [KO:K05073]
102146317  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
102143926  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
102132219  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
102115323  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
102138718  EPOR; erythropoietin receptor [KO:K05079]
101926577  CD36; CD36 molecule [KO:K06259]
102128315  GYPA; glycophorin A (MNS blood group) [KO:K06575]
102143442  CD55; CD55 molecule (Cromer blood group) [KO:K04006]
101867071  CD59; CD59 molecule [KO:K04008]
102133459  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
102117791  ITGB3; integrin subunit beta 3 [KO:K06493]
102119413  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102137361  GP9; glycoprotein IX platelet [KO:K06263]
102135994  GP1BA; glycoprotein Ib platelet alpha subunit [KO:K06261]
102118691  GP1BB; glycoprotein Ib platelet beta subunit [KO:K06262]
102143729  GP5; glycoprotein V platelet [KO:K06260]
102132675  ITGA1; integrin subunit alpha 1 [KO:K06480]
102133302  ITGA2; integrin subunit alpha 2 [KO:K06481]
102123329  ITGA3; integrin subunit alpha 3 [KO:K06482]
102128433  ITGA4; integrin subunit alpha 4 [KO:K06483]
102114969  ITGA5; integrin subunit alpha 5 [KO:K06484]
101925271  ITGA6; integrin subunit alpha 6 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
(Japanese)
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   

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