KEGG   PATHWAY: mmu00620
Entry
mmu00620                    Pathway                                

Name
Pyruvate metabolism - Mus musculus (mouse)
Class
Metabolism; Carbohydrate metabolism
Pathway map
mmu00620  Pyruvate metabolism
mmu00620

Module
mmu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mmu00620]
Other DBs
GO: 0006090
Organism
Mus musculus (mouse) [GN:mmu]
Gene
68738  Acss1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:6.2.1.1]
60525  Acss2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:6.2.1.1]
18597  Pdha1; pyruvate dehydrogenase E1 alpha 1 [KO:K00161] [EC:1.2.4.1]
18598  Pdha2; pyruvate dehydrogenase E1 alpha 2 [KO:K00161] [EC:1.2.4.1]
68263  Pdhb; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
235339  Dlat; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [KO:K00627] [EC:2.3.1.12]
13382  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
11522  Adh1; alcohol dehydrogenase 1 (class I) [KO:K13951] [EC:1.1.1.1]
11529  Adh7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
26876  Adh4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
11532  Adh5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
58810  Akr1a1; aldo-keto reductase family 1, member A1 (aldehyde reductase) [KO:K00002] [EC:1.1.1.2]
18746  Pkm; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
18770  Pklr; pyruvate kinase liver and red blood cell [KO:K12406] [EC:2.7.1.40]
107476  Acaca; acetyl-Coenzyme A carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
100705  Acacb; acetyl-Coenzyme A carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
66204  Acyp1; acylphosphatase 1, erythrocyte (common) type [KO:K01512] [EC:3.6.1.7]
75572  Acyp2; acylphosphatase 2, muscle type [KO:K01512] [EC:3.6.1.7]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
74156  Acot12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
16828  Ldha; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
16832  Ldhb; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
16833  Ldhc; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
106557  Ldhal6b; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
52815  Ldhd; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
109801  Glo1; glyoxalase 1 [KO:K01759] [EC:4.4.1.5]
14651  Hagh; hydroxyacyl glutathione hydrolase [KO:K01069] [EC:3.1.2.6]
76238  Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
107029  Me2; malic enzyme 2, NAD(+)-dependent, mitochondrial [KO:K00027] [EC:1.1.1.38]
17436  Me1; malic enzyme 1, NADP(+)-dependent, cytosolic [KO:K00029] [EC:1.1.1.40]
109264  Me3; malic enzyme 3, NADP(+)-dependent, mitochondrial [KO:K00029] [EC:1.1.1.40]
18563  Pcx; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
17449  Mdh1; malate dehydrogenase 1, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
17448  Mdh2; malate dehydrogenase 2, NAD (mitochondrial) [KO:K00026] [EC:1.1.1.37]
14194  Fh1; fumarate hydratase 1 [KO:K01679] [EC:4.2.1.2]
18534  Pck1; phosphoenolpyruvate carboxykinase 1, cytosolic [KO:K01596] [EC:4.1.1.32]
74551  Pck2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
110460  Acat2; acetyl-Coenzyme A acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
110446  Acat1; acetyl-Coenzyme A acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
224530  Acat3; acetyl-Coenzyme A acetyltransferase 3 [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00033  Acetate
C00036  Oxaloacetate
C00042  Succinate
C00058  Formate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00122  Fumarate
C00149  (S)-Malate
C00186  (S)-Lactate
C00227  Acetyl phosphate
C00256  (R)-Lactate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00469  Ethanol
C00546  Methylglyoxal
C00937  (R)-Lactaldehyde
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  (R)-2-Ethylmalate
C02504  alpha-Isopropylmalate
C03248  Acetylenedicarboxylate
C03451  (R)-S-Lactoylglutathione
C03981  2-Hydroxyethylenedicarboxylate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  Acetyl adenylate
C05994  2-Propylmalate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00020  Citrate cycle (TCA cycle)
mmu00061  Fatty acid biosynthesis
mmu00072  Synthesis and degradation of ketone bodies
mmu00260  Glycine, serine and threonine metabolism
mmu00290  Valine, leucine and isoleucine biosynthesis
mmu00630  Glyoxylate and dicarboxylate metabolism
mmu00640  Propanoate metabolism
mmu00650  Butanoate metabolism
mmu00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00620   

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