KEGG   PATHWAY: phu04341
Entry
phu04341                    Pathway                                

Name
Hedgehog signaling pathway - fly - Pediculus humanus corporis (human body louse)
Description
Hedgehog (Hh) signaling plays essential roles in embryonic development and adult tissue homeostasis. It is first elucidated by genetic studies in Drosophila and the core of the Hh signaling pathway is conserved in evolution. The Hh signaling components include an important complex composed of Cos2, Fu, SuFu and Ci. In the absence of Hh, Ptc inhibits Smo and the complex promotes the formation of the Ci's repressor form CiR. In the presentation of Hh, binding Hh to Ptc relieves Smo repression, which results in Ci's activation and then the increased transcription of Hh target genes in the nucleus.
Class
Environmental Information Processing; Signal transduction
Pathway map
phu04341  Hedgehog signaling pathway - fly
phu04341

Organism
Pediculus humanus corporis (human body louse) [GN:phu]
Gene
Phum_PHUM390440  patched 1, putative [KO:K06225]
Phum_PHUM190020  class D atypical G-protein coupled receptor GPRsmo1, putative [KO:K06226]
Phum_PHUM473100  DNA repair protein RAD50, putative [KO:K06227]
Phum_PHUM488810  cAMP-dependent protein kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
Phum_PHUM137480  cAMP-dependent protein kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
Phum_PHUM318270  cAMP-dependent protein kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
Phum_PHUM456320  cAMP-dependent protein kinase catalytic subunit, putative [KO:K08957] [EC:2.7.11.1]
Phum_PHUM048320  Casein kinase I isoform gamma-3, putative [KO:K08958] [EC:2.7.11.1]
Phum_PHUM299450  mitogen-activated protein kinase ERK-A, putative [KO:K03083] [EC:2.7.11.26]
Phum_PHUM413310  protein cubitus interruptus, putative [KO:K16799]
Phum_PHUM452780  suppressor of fused, putative [KO:K06229]
Phum_PHUM317850  F-box/WD-repeat protein 1A, putative [KO:K03362]
Phum_PHUM503280  hypothetical protein [KO:K03094]
Phum_PHUM087130  RING-box protein 1A, putative [KO:K03868] [EC:2.3.2.32]
Phum_PHUM522980  Speckle-type POZ protein, putative [KO:K10523]
Phum_PHUM346320  protein decapentaplegic precursor, putative [KO:K04662]
Phum_PHUM030340  engrailed, putative [KO:K09319]
Phum_PHUM018090  hypothetical protein [KO:K06224]
Phum_PHUM236640  skinny hedgehog/sightless/rasp, putative [KO:K24678] [EC:2.3.1.-]
Phum_PHUM490680  hypothetical protein [KO:K24680]
Phum_PHUM299830  hypothetical protein [KO:K20245]
Phum_PHUM377480  E3 ubiquitin-protein ligase Smurf1, putative [KO:K04678] [EC:2.3.2.26]
Phum_PHUM066650  cAMP-dependent protein kinase catalytic subunit, putative [KO:K08291] [EC:2.7.11.16]
Phum_PHUM587350  Cullin-3, putative [KO:K03869]
Reference
  Authors
Wilson CW, Chuang PT
  Title
Mechanism and evolution of cytosolic Hedgehog signal transduction.
  Journal
Development 137:2079-94 (2010)
DOI:10.1242/dev.045021
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Aikin RA, Ayers KL, Therond PP
  Title
The role of kinases in the Hedgehog signalling pathway.
  Journal
EMBO Rep 9:330-6 (2008)
DOI:10.1038/embor.2008.38
Reference
  Authors
Ingham PW, Nakano Y, Seger C
  Title
Mechanisms and functions of Hedgehog signalling across the metazoa.
  Journal
Nat Rev Genet 12:393-406 (2011)
DOI:10.1038/nrg2984
Reference
  Authors
Jiang J
  Title
Regulation of Hh/Gli signaling by dual ubiquitin pathways.
  Journal
Cell Cycle 5:2457-63 (2006)
DOI:10.4161/cc.5.21.3406
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J
  Title
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
  Journal
Dev Cell 10:719-29 (2006)
DOI:10.1016/j.devcel.2006.05.004
Reference
  Authors
Zhou Z, Xu C, Chen P, Liu C, Pang S, Yao X, Zhang Q
  Title
Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.
  Journal
Sci Rep 5:12709 (2015)
DOI:10.1038/srep12709
Related
pathway
phu04120  Ubiquitin mediated proteolysis
KO pathway
ko04341   

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