KEGG   PATHWAY: rn00254
Entry
rn00254                     Pathway                                

Name
Aflatoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00254  Aflatoxin biosynthesis
rn00254

Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1 [PATH:rn00254]
Other DBs
GO: 0045122
Reaction
R00742  acetyl-CoA:carbon-dioxide ligase (ADP-forming)
R03111  S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase
R03112  S-Adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase
R09756  versicolorone:NADP+ oxidoreductase
R10224  norsolorinic acid anthrone:oxygen 9-oxidoreductase (norsolorinic acid-forming)
R10239  malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)
R10307  S-adenosyl-L-methionine:dihydrosterigmatocystin 8-O-methyltransferase
R10309  (1'S)-averantin:NADP+ oxidoreductase
R10310  (1'S,5'S)-hydroxyaverantin:NAD+ oxidoreductase
R10311  (1'S,5'R)-hydroxyaverantin:NAD+ oxidoreductase
R10317  (1'S)-averantin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating)
R10318  (1'S)-averantin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating)
R10319  8-O-methylsterigmatocystin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (aflatoxin-B forming)
R10320  8-O-methyldihydrosterigmatocystin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (aflatoxin-B forming)
R10398  versiconol acetate O-acetylhydrolase
R10399  versiconol-acetate:NADP+ oxidoreductase
R10400  versiconol:NADP+ oxidoreductase
R10401  versiconal-hemiacetal-acetate O-acetylhydrolase
R10402  versiconal hydro-lyase (versicolorin-B forming)
R10403  S-adenosyl-L-methionine:dihydrodemethylsterigmatocystin 6-O-methyltransferase
R10475  5'-oxoaverantin hydro-lyase [(1'S,5'S)-averufin forming]
R10476   
R10477   
R10478   
R10479   
R10480   
R10481   
R10482   
R10483   
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00961  Sterigmatocystin
C03683  6-Demethylsterigmatocystin
C03686  O-Methylsterigmatocystin
C03944  Dihydro-O-methylsterigmatocystin
C06800  Aflatoxin B1
C16753  Aflatoxin B2
C16754  Aflatoxin G2
C16755  Aflatoxin G1
C20444  Dihydrodemethylsterigmatocystin
C20445  Dihydrosterigmatocystin
C20452  Norsolorinic acid
C20453  Norsolorinic acid anthrone
C20499  (1'S)-Averantin
C20500  (1'S,5'S)-5'-Hydroxyaverantin
C20501  (1'S,5'R)-5'-Hydroxyaverantin
C20502  5'-Oxoaverantin
C20503  1'-Hydroxyversicolorone
C20504  Versicolorone
C20505  Versiconal hemiacetal acetate
C20506  Versiconol acetate
C20507  Versiconal
C20508  Versiconol
C20574  (1'S,5'S)-Averufin
C20575  Versicolorin B
C20583  Versicolorin A
Reference
  Authors
Yu J
  Title
Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.
  Journal
Toxins (Basel) 4:1024-57 (2012)
DOI:10.3390/toxins4111024
Reference
  Authors
Yabe K, Nakajima H
  Title
Enzyme reactions and genes in aflatoxin biosynthesis.
  Journal
Appl Microbiol Biotechnol 64:745-55 (2004)
DOI:10.1007/s00253-004-1566-x
Reference
  Authors
Ehrlich KC
  Title
Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis.
  Journal
Toxins (Basel) 1:37-58 (2009)
DOI:10.3390/toxins1010037
Reference
  Authors
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC
  Title
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 107:6246-51 (2010)
DOI:10.1073/pnas.0913531107
Reference
  Authors
Sakuno E, Wen Y, Hatabayashi H, Arai H, Aoki C, Yabe K, Nakajima H
  Title
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 71:2999-3006 (2005)
DOI:10.1128/AEM.71.6.2999-3006.2005
Reference
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005
KO pathway
ko00254   

DBGET integrated database retrieval system