KEGG   PATHWAY: rn00405
Entry
rn00405                     Pathway                                

Name
Phenazine biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rn00405  Phenazine biosynthesis
rn00405

Module
M00835  Pyocyanine biosynthesis, chorismate => pyocyanine [PATH:rn00405]
Reaction
R00982  Anthranilate:CoA ligase (AMP-forming)
R00986  Chorismate pyruvate-lyase (amino-accepting)
R08956  (2S)-2-amino-4-deoxychorismate:L-glutamate aminotransferase
R09707  (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase
R10467  2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)
R10590  octanoyl-CoA:2-aminobenzoylacetate octanoyltransferase
R10966  dimethylallyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
R11346  5-methylphenazine-1-carboxylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R11463  (2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
R11489  (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate:oxygen oxidoreductase
R11490  (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate:oxygen oxidoreductase
R11491  (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate:oxygen oxidoreductase
R11492  (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate:oxygen oxidoreductase
R11533  S-adenosyl-L-methionine:phenazine-1-carboxylate 5-methyltransferase
R11542  2-aminobenzoylacetyl-CoA hydrolase
R11568   
R11569   
R11570   
R11571   
R11572   
R11573   
R11574   
R11575   
R11576   
R11577   
R11578   
R11586  anthraniloyl-CoA:malonyl-CoA anthraniloyltransferase
R11587  anthraniloyl-CoA:malonyl-CoA anthraniloyltransferase
R11589  octanoyl-CoA:2-aminobenzoylacetate octanoyltransferase
R11590  octanoyl-CoA:2-aminobenzoylacetate octanoyltransferase
Compound
C00108  Anthranilate
C00251  Chorismate
C01748  Pyocyanine
C01944  Octanoyl-CoA
C02247  Anthraniloyl-CoA
C11848  2-Heptyl-3-hydroxy-quinolone
C12119  Phenazine-1,6-dicarboxylic acid
C18054  2-Amino-2-deoxyisochorismate
C19830  (5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate
C19831  (1R,6S)-6-Amino-5-oxocyclohex-2-ene-1-carboxylate
C20643  2-Heptyl-4(1H)-quinolone
C20981  5,10-Dihydrophenazine-1-carboxylate
C20982  9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate
C21295  5-Methylphenazine-1-carboxylate
C21408  (1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate
C21409  (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1,6-dicarboxylate
C21410  (5aS)-5,5a-Dihydrophenazine-1,6-dicarboxylate
C21411  (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1-carboxylate
C21412  (10aS)-10,10a-Dihydrophenazine-1-carboxylate
C21413  (1R)-1,4,5,10-Tetrahydrophenazine-1-carboxylate
C21442  Phenazine-1-carboxylate
C21452  2-Aminobenzoylacetyl-CoA
C21453  2-Aminobenzoylacetate
C21473  (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate
C21474  5,10-Dihydrophenazine-1,6-dicarboxylate
C21475  5,10-Dihydrophenazine
C21476  Phenazine
C21477  1-Hydroxyphenazine
C21488  S-Anthraniloyl-L-cysteinyl-protein
C21489  S-Octanoyl-L-cysteinyl-protein
C21490  1-(2-Aminophenyl)decane-1,3-dione
Reference
  Authors
Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W
  Title
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013)
DOI:10.1107/S0907444913008354
Reference
  Authors
Pierson LS 3rd, Pierson EA
  Title
Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes.
  Journal
Appl Microbiol Biotechnol 86:1659-70 (2010)
DOI:10.1007/s00253-010-2509-3
Reference
  Authors
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W
  Title
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
  Journal
J Am Chem Soc 130:17053-61 (2008)
DOI:10.1021/ja806325k
Reference
  Authors
Mentel M, Ahuja EG, Mavrodi DV, Breinbauer R, Thomashow LS, Blankenfeldt W
  Title
Of two make one: the biosynthesis of phenazines.
  Journal
Chembiochem 10:2295-304 (2009)
DOI:10.1002/cbic.200900323
Reference
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure of the phenazine biosynthesis enzyme PhzG.
  Journal
Acta Crystallogr D Biol Crystallogr 60:2110-3 (2004)
DOI:10.1107/S0907444904022474
Reference
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
Related
pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko00405   

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