KEGG   PATHWAY: rn00627
Entry
rn00627                     Pathway                                

Name
Aminobenzoate degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rn00627  Aminobenzoate degradation
rn00627

Module
M00637  Anthranilate degradation, anthranilate => catechol [PATH:rn00627]
Other DBs
GO: 0043421
UMBBD: dcz 2,4-d pcp 2,4,5-t box dca
Reaction
R00815  phenol,NADPH:oxogen oxidoreductase (2-hydroxylating)
R00821  2,3-dihydroxybenzoate carboxy-lyase
R00823  Anthranilate,NADH:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
R00825  anthranilate,NADPH:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
R00980  Anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)
R00982  Anthranilate:CoA ligase (AMP-forming)
R01238  4-hydroxybenzoate carboxy-lyase (phenol-forming)
R01293  4-hydroxybenzaldehyde:NAD+ oxidoreductase
R01294  4-hydroxybenzaldehyde:NADP+ oxidoreductase
R01295  benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
R01300  4-hydroxybenzoate:CoA ligase (AMP-forming)
R01419  Benzaldehyde:NAD+ oxidoreductase
R01420  benzaldehyde:NADP+ oxidoreductase
R01421  Benzoyl phosphate phosphohydrolase
R01422  benzoate:CoA ligase (AMP-forming)
R01632  protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
R01764  benzoylformate carboxy-lyase (benzaldehyde-forming)
R02561  4-aminobenzoate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R02562  4-aminobenzoate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
R02672  4-Hydroxybenzoylformate carboxy-lyase
R02673  (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase
R02877  Vanillyl alcohol:oxygen oxidoreductase
R03023  4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)
R03024  4-nitrophenyl phosphate phosphohydrolase
R03026  (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03247  gallate carboxy-lyase
R03791  mandelate racemase
R03794  (S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
R03998  anthranilyl-CoA,NADH:oxygen oxidoreductase (de-aromatizing)
R03999  anthranilyl-CoA,NADH:oxygen oxidoreductase (de-aromatizing)
R04160   
R04277  2-pyrone-4,6-dicarboxylate lactonohydrolase
R04278  2-hydroxy-2-hydropyrone-4,6-dicarboxylate:NAD+ 6-oxidoreductase
R04279  4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
R04280  3-O-methylgallate:oxygen 4,5-oxidoreductase (decyclizing)
R04297  1,2,3,5-Tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase
R04489   
R05244  NADPH:p-benzoquinone oxidoreductase
R05258  4-nitrophenol,NADPH:oxygen 4-oxidoreductase (4-hydroxylating, nitrite-forming)
R05259  parathion,NADPH---hemoprotein reductase:oxygen oxidoreductase (paraoxon-forming)
R05265   
R05274  vanillate:oxygen oxidoreductase (demethylating)
R05277   
R05278   
R05279   
R05280   
R05308  dihydrophloroglucinol:NADP+ oxidoreductase
R05316  benzoyl-CoA:acceptor oxidoreductase
R05346   
R05383  (hydroxyamino)benzene hydroxymutase
R05394  4-Sulfolactone lyase
R05399  NADH:2-hydroxy-1,4-benzoquinone oxidoreductase
R05400  hydroxylaminobenzene:NADP+ oxidoreductase
R05401  nitrosobenzene:NADP+ oxidoreductase
R05405  2-aminophenol:oxygen 1,6-oxidoreductase (decyclizing)
R05420  4-sulfomuconolactone sulfohydrolase
R05421   
R05485   
R05486   
R05546   
R05548   
R05585   
R05590  Acylamide aminohydrolase
R05591  Nitrile aminohydrolase
R05596  benzamide hydro-lyase
R05603   
R05625  Phenylphosphate synthase
R05699  vanillin:NAD oxidoreductase
R05783  mandelamide hydrolase
R06851   
R06852   
R06853   
R06854   
R06988  3-(hydroxyamino)phenol hydroxymutase
R07664  (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase
R07668   
R07697   
R07700  aniline dioxygenase
R07706  nitrobenzene 1,2-dioxygenase
R07727   
R07730   
R07734   
R07828   
R07829   
R07831   
R07832  3-hydroxy-5-oxohexanoyl-CoA:acetate CoA-transferase
R07833   
R07835   
R07836   
R07837   
R07838   
R09270  syringate:tetrahydrofolate N-methyltransferase
R09271  3-O-methylgallate:tetrahydrofolate O-methyltransferase
R09272  3-O-methylgallate:oxygen 3,4-oxidoreductase (decyclizing)
R09273  4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate acylhydrolase
R09274   
R09275  5,5'-dehydrodivanillate,NADPH:oxygen oxidoreductase (demethylating)
R09276  2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl:oxygen 1,2-oxidoreductase (decyclizing)
R09277  4-[2-(5-carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate 5-carboxy-2-hydroxy-3-methoxybenzoylhydrolase
R09278  5-carboxyvanillate 5-carboxy-lyase (vanillate-forming)
R09284  3-(hydroxyamino)phenol hydroxymutase
R09285   
R09287   
R09288  3-hydroxyaminophenol:NAD+ oxidoreductase
R09565  gallate:oxygen oxidoreductase
R10136  vanillate:tetrahydrofolate O-methyltransferase
R12301   
Compound
C00090  Catechol
C00108  Anthranilate
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00261  Benzaldehyde
C00292  Aniline
C00472  p-Benzoquinone
C00512  Benzoyl-CoA
C00530  Hydroquinone
C00568  4-Aminobenzoate
C00632  3-Hydroxyanthranilate
C00633  4-Hydroxybenzaldehyde
C00755  4-Hydroxy-3-methoxy-benzaldehyde
C00870  4-Nitrophenol
C00877  Crotonoyl-CoA
C01108  1,2,3-Trihydroxybenzene
C01144  (S)-3-Hydroxybutanoyl-CoA
C01424  Gallate
C01502  o-Methoxyphenol
C01983  (R)-Mandelate
C01984  (S)-Mandelate
C01987  2-Aminophenol
C02137  alpha-Oxo-benzeneacetic acid
C02183  Phloroglucinol
C02222  2-Maleylacetate
C02235  4-Nitrocatechol
C02247  Anthraniloyl-CoA
C02372  4-Hydroxyaniline
C02720  Hydroxylaminobenzene
C02734  Phenolic phosphate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03198  (S)-4-Hydroxymandelate
C03360  4-Nitrophenyl phosphate
C03590  4-Hydroxyphenylglyoxylate
C03671  2-Pyrone-4,6-dicarboxylate
C03824  2-Aminomuconate semialdehyde
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C05165  2-Amino-5-oxocyclohex-1-enecarbonyl-CoA
C05616  3-O-Methylgallate
C06206  Benzoyl phosphate
C06317  Vanillyl alcohol
C06335  4-Aminobenzenesulfonate
C06337  Terephthalate
C06604  Parathion
C06605  Aminoparathion
C06606  Paraoxon
C06607  Diethylthiophosphoric acid
C06608  Diethylphosphoric acid
C06672  Vanillate
C06673  4-Carboxy-4'-sulfoazobenzene
C06674  4-Sulfocatechol
C06675  3-Sulfomuconate
C06676  4-Sulfolactone
C06719  Dihydrophloroglucinol
C06813  Nitrobenzene
C06876  Nitrosobenzene
C07103  2-Hydroxy-1,4-benzoquinone
C07301  (R)-Mandelamide
C08063  1,4-Cyclohexanedione
C09814  Benzonitrile
C09815  Benzamide
C10833  Syringic acid
C14418  3-Nitrophenol
C14602  3-Hydroxyaminophenol
C14604  Aminohydroquinone
C16200  Phenylboronic acid
C16234  o-Nitrobenzoate
C16235  o-Hydroxylaminobenzoate
C16267  Cyclopropanecarboxylate
C16268  Cyclopropanecarboxyl-CoA
C16272  3-Hydroxy-5-oxohexanoate
C16273  3-Hydroxy-5-oxohexanoyl-CoA
C16281  Thiobenzamide
C16283  Thiobenzamide S-oxide
C16285  Thiobenzamide S,S-dioxide
C18338  5-Carboxyvanillic acid
C18345  4-Carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
C18347  5,5'-Dehydrodivanillate
C18348  2,2',3-Trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl
C18349  4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate
C18351  4-Aminocatechol
Reference
PMID:3078743
  Authors
Fewson CA
  Title
Microbial metabolism of mandelate: a microcosm of diversity.
  Journal
FEMS Microbiol Rev 4:85-110 (1988)
DOI:10.1111/j.1574-6968.1988.tb02737.x
Reference
  Authors
McLeish MJ, Kneen MM, Gopalakrishna KN, Koo CW, Babbitt PC, Gerlt JA, Kenyon GL
  Title
Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.
  Journal
J Bacteriol 185:2451-6 (2003)
DOI:10.1128/JB.185.8.2451-2456.2003
Reference
PMID:8782397
  Authors
Shimao M, Nakamura T, Okuda A, Harayama S.
  Title
Characteristics of transposon insertion mutants of mandelic acid-utilizing Pseudomonas putida strain A10L.
  Journal
Biosci Biotechnol Biochem 60:1051-5 (1996)
DOI:10.1271/bbb.60.1051
Reference
  Authors
Naidu D, Ragsdale SW.
  Title
Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica.
  Journal
J Bacteriol 183:3276-81 (2001)
DOI:10.1128/JB.183.11.3276-3281.2001
Reference
  Authors
Toraya T, Oka T, Ando M, Yamanishi M, Nishihara H.
  Title
Novel pathway for utilization of cyclopropanecarboxylate by Rhodococcus rhodochrous.
  Journal
Appl Environ Microbiol 70:224-8 (2004)
DOI:10.1128/AEM.70.1.224-228.2004
Related
pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
KO pathway
ko00627   

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