KEGG   PATHWAY: rno04713
Entry
rno04713                    Pathway                                

Name
Circadian entrainment - Rattus norvegicus (rat)
Description
Circadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhythms are synchronized to environmental cues. In mammals, a master clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and may synchronize circadian oscillators in peripheral tissues. Light signal is the dominant synchronizer for master SCN clock. Downstream from the retina, glutamate and PACAP are released and trigger the activation of signal transduction cascades, including CamKII and nNOS activity, cAMP- and cGMP-dependent protein kinases, and mitogen-activated protein kinase (MAPK). Of non-photic entrainment, important phase shifting capabilities have been found for melatonin, which inhibits light-induced phase shifts through inhibition of adenylate cyclase (AC). Multiple entrainment pathways converge into CREB regulation. In turn, phosphorylated CREB activates clock gene expression.
Class
Organismal Systems; Environmental adaptation
Pathway map
rno04713  Circadian entrainment
rno04713

Other DBs
GO: 0009649
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24408  Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208]
24409  Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
24410  Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
24411  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
24412  Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212]
50663  Calm2; calmodulin-2 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
24598  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
314384  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114207  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
689560  Ryr2; ryanodine receptor 2 isoform 1 [KO:K04962]
170546  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
192363  Nos1ap; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [KO:K16513]
64455  Rasd1; dexamethasone-induced Ras-related protein 1 [KO:K07843]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
50664  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108349548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
50592  Gria1; glutamate receptor 1 precursor [KO:K05197]
29627  Gria2; glutamate receptor 2 isoform 2 precursor [KO:K05198]
29628  Gria3; glutamate receptor 3 isoform 2 precursor [KO:K05199]
29629  Gria4; glutamate receptor 4 isoform 2 precursor [KO:K05200]
29717  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 [KO:K04854]
114862  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
56827  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
24166  Adcyap1; pituitary adenylate cyclase-activating polypeptide precursor [KO:K05262]
24167  Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor [KO:K04587]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
59320  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
66012  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
497757  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
25206  Gucy1b2; guanylate cyclase soluble subunit beta-2 isoform 2 [KO:K12319] [EC:4.6.1.2]
25202  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
54286  Prkg1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
25523  Prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
192646  Mtnr1b; melatonin receptor type 1B precursor [KO:K04286]
114211  Mtnr1a; melatonin receptor type 1A [KO:K04285]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
50599  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
29713  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
25743  Kcnj6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
116560  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
287422  Per1; period circadian protein homolog 1 [KO:K21944]
63840  Per2; period circadian protein homolog 2 [KO:K02633]
78962  Per3; period circadian protein homolog 3 [KO:K21945]
314322  Fos; proto-oncogene c-Fos [KO:K04379]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
C01598  Melatonin
Reference
  Authors
Brown TM, Piggins HD
  Title
Electrophysiology of the suprachiasmatic circadian clock.
  Journal
Prog Neurobiol 82:229-55 (2007)
DOI:10.1016/j.pneurobio.2007.05.002
Reference
  Authors
Dickson L, Finlayson K
  Title
VPAC and PAC receptors: From ligands to function.
  Journal
Pharmacol Ther 121:294-316 (2009)
DOI:10.1016/j.pharmthera.2008.11.006
Reference
  Authors
Golombek DA, Rosenstein RE
  Title
Physiology of circadian entrainment.
  Journal
Physiol Rev 90:1063-102 (2010)
DOI:10.1152/physrev.00009.2009
Reference
  Authors
Dubocovich ML, Markowska M
  Title
Functional MT1 and MT2 melatonin receptors in mammals.
  Journal
Endocrine 27:101-10 (2005)
DOI:10.1385/ENDO:27:2:101
Reference
  Authors
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J
  Title
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.
  Journal
Pharmacol Rev 62:343-80 (2010)
DOI:10.1124/pr.110.002832
Reference
  Authors
Hardeland R
  Title
Melatonin: signaling mechanisms of a pleiotropic agent.
  Journal
Biofactors 35:183-92 (2009)
DOI:10.1002/biof.23
Reference
  Authors
Golombek DA, Ferreyra GA, Agostino PV, Murad AD, Rubio MF, Pizzio GA, Katz ME, Marpegan L, Bekinschtein TA
  Title
From light to genes: moving the hands of the circadian clock.
  Journal
Front Biosci 8:s285-93 (2003)
DOI:10.2741/1038
Reference
  Authors
Mertens I, Husson SJ, Janssen T, Lindemans M, Schoofs L
  Title
PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
  Journal
Peptides 28:1775-83 (2007)
DOI:10.1016/j.peptides.2007.05.005
Reference
  Authors
Kim DY, Choi HJ, Kim JS, Kim YS, Jeong DU, Shin HC, Kim MJ, Han HC, Hong SK, Kim YI
  Title
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock.
  Journal
Eur J Neurosci 21:1215-22 (2005)
DOI:10.1111/j.1460-9568.2005.03950.x
Reference
  Authors
Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA
  Title
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
  Journal
Neurochem Int 44:617-25 (2004)
DOI:10.1016/j.neuint.2003.09.005
Reference
  Authors
Ferreyra GA, Golombek DA
  Title
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
  Journal
Am J Physiol Regul Integr Comp Physiol 280:R1348-55 (2001)
DOI:10.1152/ajpregu.2001.280.5.R1348
Reference
  Authors
Butcher GQ, Lee B, Cheng HY, Obrietan K
  Title
Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism.
  Journal
J Neurosci 25:5305-13 (2005)
DOI:10.1523/JNEUROSCI.4361-04.2005
Reference
  Authors
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
  Title
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
  Journal
Brain Res 838:131-5 (1999)
DOI:10.1016/S0006-8993(99)01719-9
Reference
  Authors
Diaz-Munoz M, Dent MA, Granados-Fuentes D, Hall AC, Hernandez-Cruz A, Harrington ME, Aguilar-Roblero R
  Title
Circadian modulation of the ryanodine receptor type 2 in the SCN of rodents.
  Journal
Neuroreport 10:481-6 (1999)
DOI:10.1097/00001756-199902250-00007
Reference
  Authors
Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH
  Title
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
  Journal
Neuron 28:183-93 (2000)
DOI:10.1016/S0896-6273(00)00095-7
Reference
  Authors
Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, Ohhata T, Araki R, Abe M
  Title
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
  Journal
Brain Res Mol Brain Res 110:1-6 (2003)
DOI:10.1016/S0169-328X(02)00543-0
Reference
  Authors
Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
  Title
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
  Journal
J Neurosci 26:12984-95 (2006)
DOI:10.1523/JNEUROSCI.4253-06.2006
Related
pathway
rno04010  MAPK signaling pathway
rno04710  Circadian rhythm
KO pathway
ko04713   

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