KEGG   PATHWAY: sce03013
Entry
sce03013                    Pathway                                

Name
RNA transport - Saccharomyces cerevisiae (budding yeast)
Description
RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.
Class
Genetic Information Processing; Translation
Pathway map
sce03013  RNA transport
sce03013

Other DBs
GO: 0050658
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YNL221C  POP1; ribonuclease P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
YNL282W  POP3; Pop3p [KO:K14522] [EC:3.1.26.5]
YBR257W  POP4; RNase P/RNase MRP complex subunit [KO:K03538] [EC:3.1.26.5]
YAL033W  POP5; RNA-binding protein POP5 [KO:K03537] [EC:3.1.26.5]
YGR030C  POP6; ribonuclease P/MRP protein subunit POP6 [KO:K14524] [EC:3.1.26.5]
YBR167C  POP7; ribonuclease P/MRP protein subunit POP7 [KO:K14526] [EC:3.1.26.5]
YBL018C  POP8; ribonuclease P [KO:K14528] [EC:3.1.26.5]
YHR062C  RPP1; RNA-binding RNA processing protein RPP1 [KO:K03539] [EC:3.1.26.5]
YIR015W  RPR2; ribonuclease P protein subunit RPR2 [KO:K03540] [EC:3.1.26.5]
YML091C  RPM2; ribonuclease P [KO:K14533] [EC:3.1.26.5]
YKR079C  TRZ1; tRNase Z [KO:K00784] [EC:3.1.26.11]
YER168C  CCA1; tRNA adenylyltransferase [KO:K00974] [EC:2.7.7.72 3.1.3.- 3.1.4.-]
YLR293C  GSP1; Ran GTPase GSP1 [KO:K07936]
YOR185C  GSP2; Ran GTPase GSP2 [KO:K07936]
YKL205W  LOS1; Ran GTPase-binding protein LOS1 [KO:K14288]
YDR335W  MSN5; karyopherin MSN5 [KO:K14289]
YPR080W  TEF1; translation elongation factor EF-1 alpha [KO:K03231]
YBR118W  TEF2; translation elongation factor EF-1 alpha [KO:K03231]
YGR218W  CRM1; exportin CRM1 [KO:K14290]
YMR125W  STO1; Sto1p [KO:K12882]
YPL178W  CBC2; nuclear cap-binding protein subunit CBC2 [KO:K12883]
YBR133C  HSL7; protein arginine N-methyltransferase [KO:K02516] [EC:2.1.1.320]
YPL157W  TGS1; RNA methyltransferase [KO:K14292] [EC:2.1.1.-]
YLR347C  KAP95; karyopherin beta [KO:K14293]
YHR170W  NMD3; ribosome-binding protein NMD3 [KO:K07562]
YKR095W  MLP1; Mlp1p [KO:K09291]
YIL149C  MLP2; Mlp2p [KO:K09291]
YMR047C  NUP116; FG-nucleoporin NUP116 [KO:K14297]
YKL068W  NUP100; FG-nucleoporin NUP100 [KO:K14297]
YER107C  GLE2; RNA export factor GLE2 [KO:K14298]
YLR208W  SEC13; GTPase-activating protein SEC13 [KO:K14004]
YGL100W  SEH1; Seh1p [KO:K14299]
YKR082W  NUP133; Nup133p [KO:K14300]
YDL116W  NUP84; Nup84p [KO:K14301]
YKL057C  NUP120; Nup120p [KO:K14303]
YJR042W  NUP85; Nup85p [KO:K14304]
YJL041W  NSP1; FG-nucleoporin NSP1 [KO:K14306]
YGL172W  NUP49; FG-nucleoporin NUP49 [KO:K14307]
YGR119C  NUP57; FG-nucleoporin NUP57 [KO:K14308]
YFR002W  NIC96; linker nucleoporin NIC96 [KO:K14309]
YJL039C  NUP192; Nup192p [KO:K14310]
YML103C  NUP188; Nup188p [KO:K14311]
YBL079W  NUP170; Nup170p [KO:K14312]
YER105C  NUP157; Nup157p [KO:K14312]
YMR153W  NUP53; FG-nucleoporin NUP53 [KO:K14313]
YML031W  NDC1; Ndc1p [KO:K14315]
YMR235C  RNA1; GTPase-activating protein RNA1 [KO:K14319]
YDL064W  UBC9; E2 SUMO-conjugating protein UBC9 [KO:K10577]
YOR046C  DBP5; ATP-dependent RNA helicase DBP5 [KO:K18655] [EC:3.6.4.13]
YDL207W  GLE1; nucleoporin GLE1 [KO:K18723]
YLR192C  HCR1; translation initiation factor eIF3 core subunit J [KO:K03245]
YMR146C  TIF34; translation initiation factor eIF3 subunit I [KO:K03246]
YDR429C  TIF35; translation initiation factor eIF3 core subunit G [KO:K03248]
YMR309C  NIP1; translation initiation factor eIF3 core subunit C [KO:K03252]
YOR361C  PRT1; translation initiation factor eIF3 core subunit B [KO:K03253]
YBR079C  RPG1; translation initiation factor eIF3 core subunit A [KO:K03254]
YMR260C  TIF11; Tif11p [KO:K03236]
YNL244C  SUI1; translation initiation factor eIF1 [KO:K03113]
YPR041W  TIF5; translation initiation factor eIF5 [KO:K03262]
YJR007W  SUI2; translation initiation factor eIF2 subunit alpha [KO:K03237]
YPL237W  SUI3; translation initiation factor eIF2 subunit beta [KO:K03238]
YER025W  GCD11; translation initiation factor eIF2 subunit gamma [KO:K03242]
YKR026C  GCN3; translation initiation factor eIF2B subunit alpha [KO:K03239]
YLR291C  GCD7; translation initiation factor eIF2B subunit beta [KO:K03754]
YGR083C  GCD2; translation initiation factor eIF2B subunit delta [KO:K03680]
YOR260W  GCD1; translation initiation factor eIF2B subunit gamma [KO:K03241]
YDR211W  GCD6; translation initiation factor eIF2B catalytic subunit epsilon [KO:K03240]
YAL035W  FUN12; translation initiation factor eIF5B [KO:K03243]
YGR162W  TIF4631; translation initiation factor eIF4G [KO:K03260]
YGL049C  TIF4632; translation initiation factor eIF4G [KO:K03260]
YOL139C  CDC33; translation initiation factor eIF4E [KO:K03259]
YJL138C  TIF2; translation initiation factor eIF4A [KO:K03257]
YKR059W  TIF1; translation initiation factor eIF4A [KO:K03257]
YPR163C  TIF3; Tif3p [KO:K03258]
YER165W  PAB1; polyadenylate-binding protein [KO:K13126]
YDR532C  KRE28; Kre28p [KO:K05749]
YDR021W  FAL1; ATP-dependent RNA helicase FAL1 [KO:K13025] [EC:3.6.4.13]
YDR381W  YRA1; RNA-binding protein YRA1 [KO:K12881]
YDL084W  SUB2; ATP-dependent RNA helicase SUB2 [KO:K12812] [EC:3.6.4.13]
YNL139C  THO2; Tho2p [KO:K12879]
YNL253W  TEX1; Tex1p [KO:K12880]
YPL169C  MEX67; Mex67p [KO:K14284]
YKL186C  MTR2; Mtr2p [KO:K14543]
YMR080C  NAM7; ATP-dependent RNA helicase NAM7 [KO:K14326] [EC:3.6.4.-]
YHR077C  NMD2; Nmd2p [KO:K14327]
YGR072W  UPF3; Upf3p [KO:K14328]
snR19  SNR19 [KO:K14276]
LSR1  LSR1 [KO:K14277]
snR14  SNR14 [KO:K14278]
snR7-S  SNR7-S [KO:K14279]
snR7-L  SNR7-L [KO:K14279]
snR6  SNR6 [KO:K14280]
snR17a  SNR17A [KO:K14483]
snR17b  SNR17B [KO:K14483]
Compound
C00035  GDP
C00044  GTP
C01647  tRNA(Met)
Reference
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
  Authors
Suzuki T, Izumi H, Ohno M
  Title
Cajal body surveillance of U snRNA export complex assembly.
  Journal
J Cell Biol 190:603-12 (2010)
DOI:10.1083/jcb.201004109
Reference
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
  Authors
Pellizzoni L
  Title
Chaperoning ribonucleoprotein biogenesis in health and disease.
  Journal
EMBO Rep 8:340-5 (2007)
DOI:10.1038/sj.embor.7400941
Reference
  Authors
Gingras AC, Raught B, Sonenberg N
  Title
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
  Journal
Annu Rev Biochem 68:913-63 (1999)
DOI:10.1146/annurev.biochem.68.1.913
Reference
  Authors
Asano K, Clayton J, Shalev A, Hinnebusch AG
  Title
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
  Journal
Genes Dev 14:2534-46 (2000)
DOI:10.1101/gad.831800
Reference
PMID:9548260
  Authors
Craig AW, Haghighat A, Yu AT, Sonenberg N
  Title
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
  Journal
Nature 392:520-3 (1998)
DOI:10.1038/33198
Reference
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Related
pathway
sce03008  Ribosome biogenesis in eukaryotes
sce03010  Ribosome
sce03015  mRNA surveillance pathway
sce03020  RNA polymerase
sce03040  Spliceosome
KO pathway
ko03013   

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