KEGG   PATHWAY: sma03440
Entry
sma03440                    Pathway                                
Name
Homologous recombination - Streptomyces avermitilis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sma03440  Homologous recombination
sma03440

Other DBs
GO: 0000724
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_4288  ssb1; putative single-stranded DNA-binding protein [KO:K03111]
SAVERM_5365  ssb2; putative single-strand DNA-binding protein [KO:K03111]
SAVERM_4319  recF; putative DNA recombination and repair protein [KO:K03629]
SAVERM_5628  recO; putative DNA recombination and repair protein [KO:K03584]
SAVERM_4557  recR; putative recombination and repair protein [KO:K06187]
SAVERM_2492  recA; putative recombination protein RecA [KO:K03553]
SAVERM_6227  polA1; putative DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SAVERM_6834  ruvA; putative Holliday junction DNA helicase subunit B [KO:K03550] [EC:5.6.2.4]
SAVERM_6835  ruvB; putative Holliday junction DNA helicase subunit A [KO:K03551] [EC:5.6.2.4]
SAVERM_6833  ruvC; putative Holliday junction nuclease [KO:K01159] [EC:3.1.21.10]
SAVERM_2671  recG; putative ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
SAVERM_5329  recD; putative exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
SAVERM_6143  dnaE1; putative DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
SAVERM_4317  dnaN1; putative DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SAVERM_3362  dnaN2; putative DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SAVERM_4150  dnaZX; putative DNA polymerase III gamma and tau subunit [KO:K02343] [EC:2.7.7.7]
SAVERM_5558  holA; putative DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
SAVERM_4623  holB; putative DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
SAVERM_6439  dnaQ1; putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SAVERM_2147  dnaQ3; putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SAVERM_2004  putative siderophore biosynthesis protein/iron transport protein [KO:K02339] [EC:2.7.7.7]
SAVERM_6875  priA; putative primosomal protein [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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