KEGG   Puma concolor (puma): 112855240
Entry
112855240         CDS       T08890                                 
Symbol
EIF2AK4
Name
(RefSeq) eIF-2-alpha kinase GCN2
  KO
K16196  eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo04140  Autophagy - animal
pcoo05160  Hepatitis C
pcoo05162  Measles
pcoo05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112855240 (EIF2AK4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    112855240 (EIF2AK4)
   05162 Measles
    112855240 (EIF2AK4)
   05168 Herpes simplex virus 1 infection
    112855240 (EIF2AK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoo01001]
    112855240 (EIF2AK4)
Enzymes [BR:pcoo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112855240 (EIF2AK4)
Protein kinases [BR:pcoo01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   112855240 (EIF2AK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RWD HGTP_anticodon2 tRNA-synt_His Kinase-like ARGLU
Other DBs
NCBI-GeneID: 112855240
NCBI-ProteinID: XP_025774601
UniProt: A0A6P6HGZ5
Position
Unknown
AA seq 1653 aa
MAGGRGGPGRGPDEPPESYPQRQEHELQALEAIYGADFQDLRPDACRSVNEPPEINLVLY
PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELQNAKGLSNESVHLLKSHLEKVAKKHCGE
VMIFELADHVQSFLSEHNKPPPKSFHEEMLERRAQEEQRRLLEAKQKVEQEQREILHEIQ
RREEERKERKRKEMAKQERLEIANLSNQDQNSRKDLGGHGTAASIHGGLPDFVGNGKHRT
NSSGRSKRERQYSICSSEDSPGSCEVLYFSMGSPDQLMVYKGKCTGSDEQLGKLVYNALE
TATGNFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGAETEFNSLVKLSHPNVVHY
FAMNLKEQDDSIVVDILLEHINGVSLAAHLSHSGPIPVHQLRKYAAQLLSGLSYLHSNDV
VHKVLSASSVLVDAEGNVKITDYSISKRLADICKEDVFEQSRVSFSDSALPYKTGKKGDV
WCLGLLLISLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINP
QPKMSLLEQSPEDSGGQDYVETVIPRKQLPSAAFFSETQRQFSRYFIEFEELQLLGKGAF
GAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIERYER
PVGLGILPSDSESSPGTPQARDGRGLSRPTAQDSGRDGPGSVEATAPPPILSSVEWSTSG
ERSASARFPAAGPGSSSDEEEDDEEENDGVFSQPFLPASDSDSDIIFEDENSKSQNQDED
CNGKDSYHESEPSATTEAVHYLYIQMEYCEKSTLRDTIDQGLYQDTIRLWRLFREILDGL
AYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTADGKQDDTADHLIKPDPSG
HLTGMVGTALYVSPEVQGSTRPTYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRD
PTSPKFPEDFDDGEHTKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLH
HTLANVDGKAYRTMMAQIFSQRISPAIDYTYDSNMLKGTFSIRTAKIQQHVCDTIIRIFK
RHGAVQLCTPLLLPQNRQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKR
YCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSSLPTAEIIYTICEIIQEFPALQERNY
SIYLNHTMLLKAILLHCGIPEDKLSQVYVILYDAVTEKLTRTEVEAKFCNLSLSSNSLYR
LYKFIEQKGDLQDLTPAINSLIKQKTGVAQLVKYGLKDLEEIVGLLKKFGIKLQVLINLG
LVYKVQQHNGVIFQFVAVIRRRQRAISEILAAGGRYDLLIPQFRGPQALGPIPTAVGVSI
AIDKISAAILNMEEPVTISSCDLLVVSVGQMSMSRAINLTQKLWTVGITAQIMYDWSQSQ
EELQEYCRHHEITYVALVSDKGRSYVKVKSFEKERQTEKCVLESDLIDYVVQKLRTKVSD
ERTIREASDNLAVQNLKGSFSNASGLFEIHGAAVVPIVSVIAPEKLSASTRRRYETQVQT
RLQTSLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYL
KLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF
NT seq 4962 nt   +upstreamnt  +downstreamnt
atggctgggggccgtgggggccccgggcgcggcccggacgaaccgccggagagctatccg
cagcggcaggagcacgagctgcaggctctggaggccatctacggcgccgacttccaggac
ctgcggccggacgcgtgcagatcggtcaatgagcctcctgaaatcaatttagttctgtac
cctcagggcctaactggtgaagaagtatacgtgaaggtggatttgagggtcaaatgccca
ccaacctatccagatgtagtccccgaaatagagttacagaatgccaaaggtctgtcaaat
gagagtgttcatttattaaaatcccacctagagaaagtggccaaaaaacattgtggagag
gtgatgatatttgaactggccgaccatgtgcagtcctttctcagcgaacataacaagccc
cctcccaagtctttccatgaagaaatgctggaaagacgggctcaggaggagcagcggagg
ctgttggaggccaagcagaaagtggaacaggagcaacgtgaaatccttcatgagattcag
aggagggaagaagagagaaaagagagaaaaaggaaagaaatggctaagcaggagcgttta
gaaattgctaacttatcaaaccaagatcaaaattctaggaaagacctaggaggacatgga
acagctgccagtatacatggaggccttcccgacttcgtaggaaatggcaaacatcggacc
aactcctctggaaggtctaagcgagaacgtcagtattctatatgtagtagtgaagattct
cctggctcttgcgaagtcctgtatttctctatgggtagtcctgatcagctcatggtttac
aaagggaaatgcactggcagtgatgagcagcttggaaaattagtttacaatgctttggaa
acggccactggcaactttgtcttgttgtatgaatgggtccttcagtggcagaaaaaaatg
ggtccgttccttaccagtcaagagaaggagaagattgataagtgcaaaaagcagattcaa
ggggcagaaacggaattcaactcgctggtgaaattgagccatccaaatgtagtacactac
tttgcgatgaatctcaaagagcaagatgactccatcgtggtggacattttattggagcat
attaatggggtctctctcgccgcacacctgagccactcaggccccatccccgttcatcag
ctccgcaagtacgcagctcagctcttgtcgggcctcagttatttgcacagcaacgacgtg
gtacacaaggttctgagcgcatccagtgtcttggtggatgcagagggcaatgtcaagatt
acagactacagcatttctaagcgcctagcagacatttgcaaggaggacgtatttgagcaa
agccgagttagtttcagtgacagcgccctgccttataaaactggaaagaaaggagacgtt
tggtgtcttggccttctgctgatctccctcagccaaggacaagaatgtggagagtaccct
gtgaccatccctagcgacttaccagctgacttccaagattttctaaagaagtgtgtttgc
ttggatgataaggaaagatggagtccccagcagttgttgaaacacagctttatcaatcct
cagccgaaaatgtctttactggaacaaagtcctgaagactcgggaggacaagattatgtt
gagaccgttattcctaggaagcagctacccagtgcggcattcttcagtgagacacagaga
cagttttcccggtacttcatcgagtttgaagaattacagcttctcggcaaaggagctttt
ggggctgtcatcaaggtgcagaacaagctggacggctgctgctacgcggtgaagcgcatc
cccatcaacccggccagcaggcatttccgcaggatcaagggcgaggtgaccctgctgtca
cgcctgcaccatgagaacatcgtgcgctactacaacgcctggatcgagagatacgagcgg
ccggtgggcctggggatcctgccctcggactcggagtccagcccagggacgccccaggcc
cgggacgggcgaggtttgtctcggcctaccgcacaggacagcgggcgggacggccccggc
agcgtggaggccaccgcgccaccgcccatcctcagctcagtggagtggagcacctcgggg
gagcgctcggccagcgcccgcttccccgccgctggcccgggctccagcagcgacgaggaa
gaggacgacgaggaggagaacgacggtgtcttctcgcagcccttcctacctgcttcagat
tctgacagtgatatcatctttgaagatgagaacagtaagagtcagaatcaggatgaagac
tgcaatgggaaggacagttaccatgaaagtgagccatcggcgaccactgaggctgtgcac
tacctatatatccagatggagtactgtgagaagagcactttgcgagacaccattgaccag
ggactgtatcaggataccatcagactctggaggctttttcgagagattctggatggattg
gcttatatccatgagaaaggaatgattcaccgggatttgaagcctgtcaacatttttttg
gattccgatgaccatgtaaaaataggtgattttggtttggcgacagaccatctagccttc
acggctgatggcaagcaagatgatacagcagatcacttgattaagccagacccttcaggt
catttgacggggatggttggcactgctttgtacgtaagcccagaggtccaaggaagcacc
agacccacgtataaccagaaagtggatctcttcagcctgggaattatcttctttgagatg
tcctaccaccccatggtcacggcctcagaaaggatctttgttctcaaccaactcagagat
cccacgtcgcctaagtttccagaagacttcgatgatggagagcatacaaagcagaaatct
gtcatctcgtggctgttgaaccatgatcccgccaagcggcccacggccacagaactgctc
aagagtgagctgctgcccccaccccagatggaggagtcggaactgcacgaagttctgcac
cacaccctggccaacgtggatggcaaggcctaccgcaccatgatggcccagatcttctcc
cagcgcatctcccccgccatcgattacacctacgacagcaacatgctgaagggcaccttc
tcaatccgtacagccaagatacagcaacatgtgtgtgacaccatcatccgcatctttaaa
agacatggagctgtccagctgtgtaccccactcctgcttccccaaaataggcaaatatat
gagcacaacgaagccgccttattcatggaccacagcgggatgctggtgatgcttcctttc
gacctgcgggttccttttgcaagatacgttgcgagaaacaatatattgaatttgaaacga
tactgcatagaacgtgtgttcagacctcgcaagttagaccgatttcatcccaaagagctt
ctggagtgtgcatttgatattgtcacatctaccaccaacagctctctgcccactgccgaa
atcatctatacgatctgtgaaatcatccaggagttcccagcgcttcaggaaagaaattac
agtatttacctgaaccataccatgttattgaaagcaatcctcttacactgtgggatccca
gaagataaactcagtcaagtctatgttattctgtatgatgccgtgacagaaaagctgaca
aggacagaagtggaagccaagttttgtaatctgtctttgtcgtctaatagtctgtatcga
ctctacaaatttattgagcagaagggagatttgcaagatctcacgccagcaataaattcg
ttaataaaacagaaaacaggtgttgcccagttggtgaagtacggcttaaaagatctagag
gagattgttggacttctgaagaaatttggcataaagttacaggtcttgatcaacttgggc
ttggtttataaggtgcagcagcacaacggagtcatcttccagtttgtggcggtcatcaga
cggaggcaaagggctatatctgaaatccttgcggctggtggccgatacgacctgctgatt
ccccagtttagaggaccacaggctctggggccaatccccactgctgttggggtcagcata
gctatagacaagatatctgctgctatcctcaacatggaagaacctgttacaatcagctct
tgtgacctcctggtcgtaagtgttggccagatgtccatgtccagggccatcaacctcacc
cagaaactctggacggtgggaatcacggcacaaatcatgtatgactggtcgcagtcccaa
gaagaactccaggaatactgcagacatcacgaaatcacctacgtggcccttgtctcagat
aaaggacgaagctatgtcaaggttaagtcttttgagaaggaaaggcaaacagagaaatgc
gtgctggagtctgatcttatagactatgttgtgcagaaactcaggactaaagtcagtgat
gaaaggactatcagagaagcttccgataatcttgcagtgcaaaatctgaaggggtcattt
tctaatgcttcaggtttgtttgaaatccatggagccgctgttgttcccattgtgagtgtg
atcgccccagagaagctgtcagccagcactaggaggcggtatgaaactcaggtacaaacc
cgacttcagacctcccttgccaacttacatcagaaaagcagtgaaattgaaattctggct
gtggatctacccaaagaaaccatcctacagtttttatcattagagtgggatgctgatgaa
caggcatttaatacaactgtgaagcagctgctgtcccgcctgccaaagcaaagatacctc
aaattagtctgtgatgaaatttataacatcaaagtagaaaaaaaggtatctgtgttattc
ctgtatagctacagagatgactactacagaattttattttaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (12)   

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