KEGG   Puma concolor (puma): 112859389
Entry
112859389         CDS       T08890                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo00230  Purine metabolism
pcoo01100  Metabolic pathways
pcoo01522  Endocrine resistance
pcoo04015  Rap1 signaling pathway
pcoo04020  Calcium signaling pathway
pcoo04022  cGMP-PKG signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04062  Chemokine signaling pathway
pcoo04072  Phospholipase D signaling pathway
pcoo04081  Hormone signaling
pcoo04082  Neuroactive ligand signaling
pcoo04114  Oocyte meiosis
pcoo04211  Longevity regulating pathway
pcoo04213  Longevity regulating pathway - multiple species
pcoo04261  Adrenergic signaling in cardiomyocytes
pcoo04270  Vascular smooth muscle contraction
pcoo04371  Apelin signaling pathway
pcoo04540  Gap junction
pcoo04611  Platelet activation
pcoo04713  Circadian entrainment
pcoo04714  Thermogenesis
pcoo04720  Long-term potentiation
pcoo04723  Retrograde endocannabinoid signaling
pcoo04724  Glutamatergic synapse
pcoo04725  Cholinergic synapse
pcoo04727  GABAergic synapse
pcoo04742  Taste transduction
pcoo04750  Inflammatory mediator regulation of TRP channels
pcoo04911  Insulin secretion
pcoo04912  GnRH signaling pathway
pcoo04913  Ovarian steroidogenesis
pcoo04914  Progesterone-mediated oocyte maturation
pcoo04915  Estrogen signaling pathway
pcoo04916  Melanogenesis
pcoo04918  Thyroid hormone synthesis
pcoo04921  Oxytocin signaling pathway
pcoo04923  Regulation of lipolysis in adipocytes
pcoo04925  Aldosterone synthesis and secretion
pcoo04926  Relaxin signaling pathway
pcoo04927  Cortisol synthesis and secretion
pcoo04928  Parathyroid hormone synthesis, secretion and action
pcoo04934  Cushing syndrome
pcoo04935  Growth hormone synthesis, secretion and action
pcoo04970  Salivary secretion
pcoo04971  Gastric acid secretion
pcoo04972  Pancreatic secretion
pcoo04976  Bile secretion
pcoo05032  Morphine addiction
pcoo05163  Human cytomegalovirus infection
pcoo05166  Human T-cell leukemia virus 1 infection
pcoo05200  Pathways in cancer
pcoo05207  Chemical carcinogenesis - receptor activation
pcoo05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    112859389 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112859389 (ADCY8)
   04371 Apelin signaling pathway
    112859389 (ADCY8)
   04020 Calcium signaling pathway
    112859389 (ADCY8)
   04072 Phospholipase D signaling pathway
    112859389 (ADCY8)
   04024 cAMP signaling pathway
    112859389 (ADCY8)
   04022 cGMP-PKG signaling pathway
    112859389 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112859389 (ADCY8)
   04081 Hormone signaling
    112859389 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    112859389 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112859389 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112859389 (ADCY8)
   04062 Chemokine signaling pathway
    112859389 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    112859389 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    112859389 (ADCY8)
   04912 GnRH signaling pathway
    112859389 (ADCY8)
   04913 Ovarian steroidogenesis
    112859389 (ADCY8)
   04915 Estrogen signaling pathway
    112859389 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    112859389 (ADCY8)
   04921 Oxytocin signaling pathway
    112859389 (ADCY8)
   04926 Relaxin signaling pathway
    112859389 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    112859389 (ADCY8)
   04918 Thyroid hormone synthesis
    112859389 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    112859389 (ADCY8)
   04916 Melanogenesis
    112859389 (ADCY8)
   04925 Aldosterone synthesis and secretion
    112859389 (ADCY8)
   04927 Cortisol synthesis and secretion
    112859389 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112859389 (ADCY8)
   04270 Vascular smooth muscle contraction
    112859389 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    112859389 (ADCY8)
   04971 Gastric acid secretion
    112859389 (ADCY8)
   04972 Pancreatic secretion
    112859389 (ADCY8)
   04976 Bile secretion
    112859389 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    112859389 (ADCY8)
   04727 GABAergic synapse
    112859389 (ADCY8)
   04725 Cholinergic synapse
    112859389 (ADCY8)
   04720 Long-term potentiation
    112859389 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    112859389 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    112859389 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    112859389 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    112859389 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    112859389 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112859389 (ADCY8)
   04714 Thermogenesis
    112859389 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112859389 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    112859389 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112859389 (ADCY8)
   05163 Human cytomegalovirus infection
    112859389 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    112859389 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    112859389 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112859389 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    112859389 (ADCY8)
Enzymes [BR:pcoo01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     112859389 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD AGTRAP
Other DBs
NCBI-GeneID: 112859389
NCBI-ProteinID: XP_025778382
UniProt: A0A6P6HRG5
Position
Unknown
AA seq 1252 aa
MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG
SGSRGSGKASDAAGGGPNHHAAQLSGDSALPLYSLGPGERAHSSGGTKVFPERSGSGSGS
GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR
KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH
TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT
SLLQVVVQVAIPRLAVISINQVMAQAVLFMCMNTAGTFISYLSDRAQRQAFLETRRCVEA
RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD
VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA
HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK
LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLTLPE
DIVKESVSFSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH
VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA
FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN
ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSCPEYFVFT
GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGDFFVQTTG
ISILYSPVSLLFFLSRARQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV
ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD
ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK
HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI
LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL
VQSLNRQRQKQLLNENINTGIIKGHYNRRTLLTPSGPEPGAQAEGADKSDLP
NT seq 3759 nt   +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgcctgagcggcagcgaggaactctacaccattcacccg
acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg
gcggtgaggcacatcaccgagcagcgcttcattcacgggcaccggggcagcggcggcggc
agcgggagtagaggctccggcaaagcctcggacgctgcaggcggcggccccaaccaccac
gcggcgcagctgtccggggactcggcgctgcccctctactcgctgggccccggggagaga
gcgcacagctccggtggcaccaaagtcttcccggaacgcagcgggagcggcagcggcagc
ggcagcgggggcgggggcgatctgggcttcctgcacctggactgcgccccgagcaactcg
gatttcttcctcaatgggggctatagctaccgaggggtcattttccccactctgcgcaac
tccttcaagtccagggatctggagcgcctctaccagcgctatttcctgggccagaggcgc
aaatccgaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggtcctc
cacctgagcctggcctcggcccccatggacccgctcaagggcattctcctgggcttcttc
actggcatcgaggtggtgatctgcgcgctcgtggtggtcaggaaggacaccacctcgcac
acgtacctgcagtacagcggcgtggtcacttgggtggccatgaccacccagatcttggca
gcaggcctcggctacgggcttctgggtgatggcatcggctacgtcctcttcacgctgttc
gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctgggcacc
tcgctgctgcaggtggtcgtgcaggtggccattccccggctggcggtcatctccatcaac
caggtgatggcccaggcagtgctgttcatgtgtatgaacacggctggaaccttcatcagt
tacctgtcagaccgggcccagcgccaagccttcctggagacacggaggtgtgtggaggcc
aggctgcgcctggagacggaaaaccaaagacaggagcggctcgtgctgtctgtgcttccc
cggtttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacctgcag
caccaattccatcggatctacatccaccgctatgagaatgtcagtattcttttcgcagat
gtgaaaggatttaccaacctctccacaaccttgtctgcccaggagctggtcaggatgctc
aacgagctctttgccagatttgatcgactggcccacgagcatcactgccttcgcattaaa
atcctgggggactgttactactgtgtttcagggcttccagagccccgccaggaccacgcc
cactgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcaagg
acgaagcatgatgttgacatgcggatcggaatccactcgggctcggtgctgtgtggcgtg
ttgggtctgagaaagtggcagtttgatgtctggtcttgggatgtggacatcgcgaacaaa
cttgagtctggaggaatccctgggaggattcacatttccaaagccacgctggactgcctc
aacggtgactataatgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag
cataacatagagacctatttgattaagcagcctgaggagagtctactgacgttgcccgaa
gacattgtcaaggagtcggtgagcttctcagacaggagaaacagtggggcgacattcaca
gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg
gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat
gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt
ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc
ctggagcacaagtattctcaaatgagggacgaagtattcaagtcaaacttggtctgtgca
tttatcgttctcctatttatcacggcaatccaaagtttgcttccttcttcaagggtgatg
ccaatggccatccagttttccatcctgatcatgctgcactcggctctggtcctcatcacc
acggcagaagattacaagtgtttgcctctggtcctccggaaaacttgctgttggattaac
gagacctacttagcccggaacgtcatcatctttgcatccatcttgattaacttcctgggc
gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact
ttcaattcctcagctgtgtttacagatatctgctcctgcccagagtacttcgtcttcact
ggggtgttggccatggtgacctgtgcggttttcctccgcctgaactctgtcctgaagctg
gccgtgctgctgattatgattgccatctacgcgctgctgactgagaccgtctacgcgggc
ctcttcctgcgctatgacaacctaaaccacagcggagatttctttgtgcaaaccacgggg
ataagtatattatactcacctgtttcccttctcttctttctctctcgtgcccggcagctg
gagtacacggcccgcctggacttcctttggcgagtgcaggccaaagaggagatcaacgag
atgaaggagctcagggagcacaatgagaacatgctccggaacattctacccagccacgtg
gcccgccacttcctggagaaagaccgagacaacgaggagctgtattcccaatcttatgat
gccgttggggtgatgttcgcctccatcccggggtttgcagacttttactctcagactgag
atgaataaccagggagtagaatgcctgcgtctgttgaatgagatcattgctgacttcgat
gagctgctaggcgaagaccggtttcaggacattgaaaagattaagaccatcggcagcacc
tacatggccgtgtcgggcctgtcacctgaaaaacagcaatgtgaagacaagtggggacat
ctgtgtgccctggccgacttctccctcgccctgaccgaaagcatacaggagatcaacaaa
cattccttcaacaatttcgaactccggattggcatcagtcacggctccgtggtagctggg
gtcatcggcgctaagaagccacagtatgacatttggggcaaaactgtgaacctggcgagc
cgaatggacagcacaggggtcagcggcaggatccaagtccccgaggagacctatctcatc
ctgaaggaccagggctttgccttcgactaccgaggggagatctacgtgaagggcatcagt
gagcaggaagggaaaatcaaaacgtactttctcctgggaagagtccaacccaacccgttc
atcctgcccccgagaagactgcccgggcagtactcactggccgcagtcgtcctgggcctt
gtccagtccctcaacaggcaaaggcagaagcagttgctcaatgagaacatcaacacaggg
atcatcaagggccactacaaccggcggactttgctgacacccagtgggccagagcccggg
gcccaggctgagggcgccgacaagtccgatttgccatga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (5)   
   Pfam (5)   
All databases (10)   

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