KEGG   Puma concolor (puma): 112869712
Entry
112869712         CDS       T08890                                 
Symbol
HK2
Name
(RefSeq) hexokinase-2
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo00010  Glycolysis / Gluconeogenesis
pcoo00051  Fructose and mannose metabolism
pcoo00052  Galactose metabolism
pcoo00500  Starch and sucrose metabolism
pcoo00520  Amino sugar and nucleotide sugar metabolism
pcoo01100  Metabolic pathways
pcoo01200  Carbon metabolism
pcoo01250  Biosynthesis of nucleotide sugars
pcoo04066  HIF-1 signaling pathway
pcoo04910  Insulin signaling pathway
pcoo04930  Type II diabetes mellitus
pcoo04973  Carbohydrate digestion and absorption
pcoo05230  Central carbon metabolism in cancer
Module
pcoo_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
pcoo_M00549  UDP-Glc biosynthesis, Glc => UDP-Glc
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    112869712 (HK2)
   00051 Fructose and mannose metabolism
    112869712 (HK2)
   00052 Galactose metabolism
    112869712 (HK2)
   00500 Starch and sucrose metabolism
    112869712 (HK2)
  09107 Glycan biosynthesis and metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    112869712 (HK2)
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    112869712 (HK2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    112869712 (HK2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    112869712 (HK2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112869712 (HK2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    112869712 (HK2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112869712 (HK2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcoo04131]
    112869712 (HK2)
Enzymes [BR:pcoo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     112869712 (HK2)
Membrane trafficking [BR:pcoo04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    112869712 (HK2)
SSDB
Motif
Pfam: Hexokinase_2 Hexokinase_1
Other DBs
NCBI-GeneID: 112869712
NCBI-ProteinID: XP_025788615
UniProt: A0A6P6IK81
Position
Unknown
AA seq 889 aa
MRLSDENLLEISQRFRKEMEKGLGATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGT
NFRVLRVRVTDNGLQKVEMENQIYAIPEDLMRGSGTQLFDHIAECLANFMDKLQIKDKKL
PLGFTFSFPCVQTKLDESFLVSWTKGFKSSGVEGKDVVTLIRKAIQRRGDFDIDIVAVVN
DTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDG
TLDDFRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPGL
LATGHFETKDVSDIEGEKDGIRKAREVLVRLGIDPTQEDCVATHRVCQIVSTRSASLCAA
TLAAVLRRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPDCDVRFLRSEDG
SGKGAAMVTAVAYRLADQHRARQNTLESLKLNREQLLEVKKRMKVEMERGLSKETHTIAP
VKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMH
GTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGC
EGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEIGLIVGTGSNACYME
EMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGM
YLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILHHLG
LESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDTLKVTVGVDGTLYKLH
PHFAKVMHETVKDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
NT seq 2670 nt   +upstreamnt  +downstreamnt
atgcgtctttctgatgagaaccttctggagatctctcagcggttccgcaaggagatggaa
aaagggcttggagccaccacccaccctactgcttcagtgaaaatgctgcccacctttgtg
aggtctactccagatgggacagaacatggagagtttctggctctggaccttggggggacc
aacttccgtgtgcttcgtgtaagagtaacagacaatgggctccagaaggttgagatggag
aaccagatctatgccatccctgaggacctcatgcgaggcagcggcacccagctgtttgac
cacattgctgaatgcctggctaacttcatggataagctacaaatcaaagacaagaagctc
cccttgggttttactttctcattcccctgtgtccaaacgaagctagatgagagtttcctg
gtctcctggaccaaggggttcaagtccagtggcgtggaaggcaaagacgtggttactctg
atccggaaggccatccagaggagaggggactttgatattgatattgtggccgtggtgaat
gacacagttgggaccatgatgacctgtggttatgatgaccagaattgtgagattggtctc
attgtgggcacgggcagcaatgcctgctacatggaagagatgcgccacattgacatggtg
gagggcgacgaggggcggatgtgtatcaacatggagtggggggcctttggggacgacggc
acacttgatgacttccgcactgagtttgatcaggagatcgacatgggctccctgaaccct
gggaagcaactatttgagaagatgatcagtgggatgtatatgggtgaactggtgagactt
atcctggtgaagatggccaaggaggagctgctttttggagggaagctcagcccagggctc
ctcgccactggccactttgagaccaaagacgtttcagatattgaaggggagaaggacggc
atccggaaggcccgtgaggtgctagtgcggctgggcatagacccgacgcaggaggactgc
gtggccactcaccgggtgtgccagattgtgtccacacgctcagccagcctgtgtgcagcc
accctggcagccgtgctgcggcgcatcaaggagaacaagggcgaggagaggctgcgctcc
accattggggttgatggttctgtctacaagaagcaccctcatttcgccaagcgtcttcac
aagacggttcggcgcctggtgcccgactgcgacgtccgtttcctgcgttctgaggatggc
agtggcaagggggcagccatggtgacggcagtggcctaccggctggctgaccaacacaga
gcccgccagaataccctggagtctctgaagctgaaccgtgagcagctgctagaggttaag
aagaggatgaaggtagaaatggagcgaggtctgagcaaggagacccacaccattgccccc
gtcaagatgctgcccacctacgtgtgtgccacccctgatggcacagagaaaggtgacttc
ctggccttggaccttgggggtaccaatttccgggtcctgctggtgcgtgtgaggaatggg
aagaggcgcggagtggagatgcacaacaagatctactctatcccacaggaggtcatgcat
ggcacaggggatgagctctttgaccacatcgtccagtgcatcgccgacttccttgagtac
atgggcatgaagggcgtgtccctgcctctgggtttcaccttctccttcccctgccagcag
aacagcctggatgagagcatcctcctcaagtggactaaaggcttcaaggcatcgggctgc
gagggagaggatgtggtcaccctgctgaaggaagccattcaccggcgagaggagtttgac
ctggatgtggtcgccgtggtgaatgacacagttgggacgatgatgacctgtggctatgaa
gaccctcactgtgaaatcggcctcattgttggcacgggcagcaacgcctgctacatggag
gagatgcggaacgtggagctggtggaaggggaggagggccggatgtgtgtcaacatggag
tggggggccttcggggacaacgggtgcctggacgacttccgcacggaatttgatgtggct
gtggatgagctttctctcaaccctggcaaacagaggtttgagaaaatgatcagtggcatg
tatttgggcgagattgtccgtaacatcctcatcgatttcaccaagcgtgggctgctcttc
cgtggccgcatctcagaacgactcaagacaagaggaatctttgaaaccaagttcctgtct
cagattgagagtgactgcctagccctgctgcaagtccgagccatcctgcaccacctgggg
ctcgagagcacctgtgacgacagcatcatcgtcaaagaggtgtgcacggtcgtggcacgg
cgggcggcccagctctgtggtgcgggcatggccgccgtggtggacaaaatacgagaaaac
cgtgggttggacaccctcaaagtgacagttggcgtggatgggaccctctacaagctacat
cctcactttgccaaagtcatgcatgagacggtgaaagacctggctccgaaatgtgatgtg
tccttcctggagtcagaggatggcagcgggaagggggcagctctcatcactgctgtggcc
tgccgcatccgtgaggctggacagcgatag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (7)   

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