KEGG   Propithecus coquereli (Coquerel's sifaka): 105818191
Entry
105818191         CDS       T08746                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq01521  EGFR tyrosine kinase inhibitor resistance
pcoq01522  Endocrine resistance
pcoq01524  Platinum drug resistance
pcoq04012  ErbB signaling pathway
pcoq04014  Ras signaling pathway
pcoq04015  Rap1 signaling pathway
pcoq04024  cAMP signaling pathway
pcoq04062  Chemokine signaling pathway
pcoq04066  HIF-1 signaling pathway
pcoq04068  FoxO signaling pathway
pcoq04070  Phosphatidylinositol signaling system
pcoq04071  Sphingolipid signaling pathway
pcoq04072  Phospholipase D signaling pathway
pcoq04081  Hormone signaling
pcoq04140  Autophagy - animal
pcoq04145  Phagocytosis
pcoq04150  mTOR signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04152  AMPK signaling pathway
pcoq04210  Apoptosis
pcoq04211  Longevity regulating pathway
pcoq04213  Longevity regulating pathway - multiple species
pcoq04218  Cellular senescence
pcoq04360  Axon guidance
pcoq04370  VEGF signaling pathway
pcoq04380  Osteoclast differentiation
pcoq04510  Focal adhesion
pcoq04517  IgSF CAM signaling
pcoq04518  Integrin signaling
pcoq04550  Signaling pathways regulating pluripotency of stem cells
pcoq04611  Platelet activation
pcoq04613  Neutrophil extracellular trap formation
pcoq04620  Toll-like receptor signaling pathway
pcoq04625  C-type lectin receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
pcoq04650  Natural killer cell mediated cytotoxicity
pcoq04660  T cell receptor signaling pathway
pcoq04662  B cell receptor signaling pathway
pcoq04664  Fc epsilon RI signaling pathway
pcoq04666  Fc gamma R-mediated phagosome formation
pcoq04668  TNF signaling pathway
pcoq04670  Leukocyte transendothelial migration
pcoq04722  Neurotrophin signaling pathway
pcoq04725  Cholinergic synapse
pcoq04750  Inflammatory mediator regulation of TRP channels
pcoq04810  Regulation of actin cytoskeleton
pcoq04910  Insulin signaling pathway
pcoq04914  Progesterone-mediated oocyte maturation
pcoq04915  Estrogen signaling pathway
pcoq04917  Prolactin signaling pathway
pcoq04919  Thyroid hormone signaling pathway
pcoq04923  Regulation of lipolysis in adipocytes
pcoq04926  Relaxin signaling pathway
pcoq04929  GnRH secretion
pcoq04930  Type II diabetes mellitus
pcoq04931  Insulin resistance
pcoq04932  Non-alcoholic fatty liver disease
pcoq04933  AGE-RAGE signaling pathway in diabetic complications
pcoq04935  Growth hormone synthesis, secretion and action
pcoq04960  Aldosterone-regulated sodium reabsorption
pcoq04973  Carbohydrate digestion and absorption
pcoq05010  Alzheimer disease
pcoq05017  Spinocerebellar ataxia
pcoq05020  Prion disease
pcoq05100  Bacterial invasion of epithelial cells
pcoq05135  Yersinia infection
pcoq05142  Chagas disease
pcoq05146  Amoebiasis
pcoq05160  Hepatitis C
pcoq05161  Hepatitis B
pcoq05162  Measles
pcoq05163  Human cytomegalovirus infection
pcoq05164  Influenza A
pcoq05165  Human papillomavirus infection
pcoq05166  Human T-cell leukemia virus 1 infection
pcoq05167  Kaposi sarcoma-associated herpesvirus infection
pcoq05168  Herpes simplex virus 1 infection
pcoq05169  Epstein-Barr virus infection
pcoq05170  Human immunodeficiency virus 1 infection
pcoq05171  Coronavirus disease
pcoq05200  Pathways in cancer
pcoq05203  Viral carcinogenesis
pcoq05205  Proteoglycans in cancer
pcoq05206  MicroRNAs in cancer
pcoq05207  Chemical carcinogenesis - receptor activation
pcoq05208  Chemical carcinogenesis - reactive oxygen species
pcoq05210  Colorectal cancer
pcoq05211  Renal cell carcinoma
pcoq05212  Pancreatic cancer
pcoq05213  Endometrial cancer
pcoq05214  Glioma
pcoq05215  Prostate cancer
pcoq05218  Melanoma
pcoq05220  Chronic myeloid leukemia
pcoq05221  Acute myeloid leukemia
pcoq05222  Small cell lung cancer
pcoq05223  Non-small cell lung cancer
pcoq05224  Breast cancer
pcoq05225  Hepatocellular carcinoma
pcoq05226  Gastric cancer
pcoq05230  Central carbon metabolism in cancer
pcoq05231  Choline metabolism in cancer
pcoq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcoq05415  Diabetic cardiomyopathy
pcoq05417  Lipid and atherosclerosis
pcoq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105818191 (PIK3R2)
   04014 Ras signaling pathway
    105818191 (PIK3R2)
   04015 Rap1 signaling pathway
    105818191 (PIK3R2)
   04370 VEGF signaling pathway
    105818191 (PIK3R2)
   04630 JAK-STAT signaling pathway
    105818191 (PIK3R2)
   04668 TNF signaling pathway
    105818191 (PIK3R2)
   04066 HIF-1 signaling pathway
    105818191 (PIK3R2)
   04068 FoxO signaling pathway
    105818191 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    105818191 (PIK3R2)
   04072 Phospholipase D signaling pathway
    105818191 (PIK3R2)
   04071 Sphingolipid signaling pathway
    105818191 (PIK3R2)
   04024 cAMP signaling pathway
    105818191 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    105818191 (PIK3R2)
   04152 AMPK signaling pathway
    105818191 (PIK3R2)
   04150 mTOR signaling pathway
    105818191 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105818191 (PIK3R2)
   04517 IgSF CAM signaling
    105818191 (PIK3R2)
   04518 Integrin signaling
    105818191 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    105818191 (PIK3R2)
   04140 Autophagy - animal
    105818191 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    105818191 (PIK3R2)
   04218 Cellular senescence
    105818191 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105818191 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    105818191 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105818191 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105818191 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    105818191 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    105818191 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    105818191 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    105818191 (PIK3R2)
   04660 T cell receptor signaling pathway
    105818191 (PIK3R2)
   04662 B cell receptor signaling pathway
    105818191 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    105818191 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    105818191 (PIK3R2)
   04670 Leukocyte transendothelial migration
    105818191 (PIK3R2)
   04062 Chemokine signaling pathway
    105818191 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105818191 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    105818191 (PIK3R2)
   04929 GnRH secretion
    105818191 (PIK3R2)
   04915 Estrogen signaling pathway
    105818191 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    105818191 (PIK3R2)
   04917 Prolactin signaling pathway
    105818191 (PIK3R2)
   04926 Relaxin signaling pathway
    105818191 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    105818191 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    105818191 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105818191 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105818191 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    105818191 (PIK3R2)
   04722 Neurotrophin signaling pathway
    105818191 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105818191 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    105818191 (PIK3R2)
   04380 Osteoclast differentiation
    105818191 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    105818191 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    105818191 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105818191 (PIK3R2)
   05206 MicroRNAs in cancer
    105818191 (PIK3R2)
   05205 Proteoglycans in cancer
    105818191 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    105818191 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    105818191 (PIK3R2)
   05203 Viral carcinogenesis
    105818191 (PIK3R2)
   05230 Central carbon metabolism in cancer
    105818191 (PIK3R2)
   05231 Choline metabolism in cancer
    105818191 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105818191 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105818191 (PIK3R2)
   05212 Pancreatic cancer
    105818191 (PIK3R2)
   05225 Hepatocellular carcinoma
    105818191 (PIK3R2)
   05226 Gastric cancer
    105818191 (PIK3R2)
   05214 Glioma
    105818191 (PIK3R2)
   05221 Acute myeloid leukemia
    105818191 (PIK3R2)
   05220 Chronic myeloid leukemia
    105818191 (PIK3R2)
   05218 Melanoma
    105818191 (PIK3R2)
   05211 Renal cell carcinoma
    105818191 (PIK3R2)
   05215 Prostate cancer
    105818191 (PIK3R2)
   05213 Endometrial cancer
    105818191 (PIK3R2)
   05224 Breast cancer
    105818191 (PIK3R2)
   05222 Small cell lung cancer
    105818191 (PIK3R2)
   05223 Non-small cell lung cancer
    105818191 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105818191 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    105818191 (PIK3R2)
   05161 Hepatitis B
    105818191 (PIK3R2)
   05160 Hepatitis C
    105818191 (PIK3R2)
   05171 Coronavirus disease
    105818191 (PIK3R2)
   05164 Influenza A
    105818191 (PIK3R2)
   05162 Measles
    105818191 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    105818191 (PIK3R2)
   05163 Human cytomegalovirus infection
    105818191 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105818191 (PIK3R2)
   05169 Epstein-Barr virus infection
    105818191 (PIK3R2)
   05165 Human papillomavirus infection
    105818191 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105818191 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    105818191 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105818191 (PIK3R2)
   05142 Chagas disease
    105818191 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105818191 (PIK3R2)
   05017 Spinocerebellar ataxia
    105818191 (PIK3R2)
   05020 Prion disease
    105818191 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105818191 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    105818191 (PIK3R2)
   05415 Diabetic cardiomyopathy
    105818191 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105818191 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    105818191 (PIK3R2)
   04931 Insulin resistance
    105818191 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105818191 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105818191 (PIK3R2)
   01524 Platinum drug resistance
    105818191 (PIK3R2)
   01522 Endocrine resistance
    105818191 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcoq04131]
    105818191 (PIK3R2)
Membrane trafficking [BR:pcoq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105818191 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 Ribosomal_L22e ODF2_C
Other DBs
NCBI-GeneID: 105818191
NCBI-ProteinID: XP_012509578
Ensembl: ENSPCOG00000021064
UniProt: A0A2K6FWL8
Position
Unknown
AA seq 726 aa
MAGAEGFQYRALYPFHRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQTVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLALPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESYYRPELPAPRTDWSLSDVDQWDATALADGIKGFLLA
LPAPLVTPEASAEARRALREAAGPLGPLLEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPSPPPAGAPDGSEPSPDFPAVLVEKLLQEHLEEQEVAPPAL
PPKPSKVKPAAAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLISHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPAAR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggcaggcgctgagggcttccagtaccgggcactgtacccgttccaccgggagcggcca
gaggacctggagctgctgccgggcgacgtgctggtggtgagccgggcggccctgcaggcg
ctgggcgtggctgagggtggcgagcgctgcccgcagaccgtgggctggatgcccggcctc
aacgaacgcacgcggcagcgaggtgacttccctggcacctacgtggagttcctagggcct
gtggccctggcccggcccggccctcgcccacgcggcccccgcccactgcccgccaggcca
cgcgatgggccccctgagccaggccttgcactccccgacctgccagagcagttctcccct
cctgatgtggcaccccctcttctggtgaagctcgtggaggccattgagcggacagggctg
gacagcgaatcctactacaggccggagctgcccgccccgcgcacagactggtccctgagc
gacgtggatcagtgggacgccacagccctggcagacggcattaagggcttcctgctggct
ctgcccgcacccctcgtgacacccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcggggcccctggggccgctgctggagcccccgacgctgccgctgcaccgcgccctc
acgctgcgcttcctgctgcagcacctgggccgcgtggcccgccgcgcccccgccctgggt
cccgcggtgcgggcgctgggcgccaccttcgggccgctgctgctgcgcgcaccgccgccc
tcgccgccgcccgcgggcgcgcctgatgggagtgagcccagccctgacttcccggcagtg
ctggtggagaagctgcttcaggaacatttggaagagcaggaggttgcgcccccagcgctg
ccgcctaaaccctctaaggtaaagccggccgccgcaggcctagccaatggcgggagccca
ccctccctgcaagacgctgagtggtactggggggacatctccagggaggaagtgaatgag
aaactccgggacacacctgatggcacctttctggtccgtgacgcatccagcaagatccag
ggggagtacacgctgaccctcaggaaaggcgggaacaacaagctgataaaggtcttccac
cgcgacgggcactatggcttctcggagccgctgaccttctgctccgtcgtggacctcatc
agccactaccgccacgagtcgctggcccagtataacgccaagctggacacgcggctcctc
tacccggtgtccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaggcggtg
ggcgcccagctcaaggtctaccaccagcagtaccaggacaagagccgcgagtacgaccag
ctctacgaggagtacacacgcacctcccaggagctacagatgaagcgcacagcaatcgag
gccttcaacgagaccatcaagatctttgaagagcagggccagacgcaggagaagtgcagc
aaggaatatctagagcgcttccggcgtgagggcaacgagaaggagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgcagagatccacgagagccgcacgaagctg
gagcagcagctgcgggcacaggcctcggacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctcacc
cagaaaggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaacgagactgag
gaccagtacgcactgatggaagacgaggacgatctcccccaccacgaggagcgcacgtgg
tacgtgggcaagatcaaccgcacacaggctgaggagatgctgagcggcaagcgggacggc
accttcctcatccgcgagagcagccagcgcggctgttacgcctgctcggtggtggtggac
ggtgacaccaagcactgcgtcatctaccgcactgccaccggcttcggcttcgcggagccc
tacaacctgtacgggtctctgaaggagctggtgctgcactaccagcacgcgtcgctcgtg
cagcacaacgacgcgctcaccgtcaccctcgcgcaccccgtgcgcgccccgggccccggc
ccgccgcctgccgcccgctga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (14)   

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