KEGG   Pseudorca crassidens (false killer whale): 137222266
Entry
137222266         CDS       T12027                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pcrs  Pseudorca crassidens (false killer whale)
Pathway
pcrs01521  EGFR tyrosine kinase inhibitor resistance
pcrs01522  Endocrine resistance
pcrs01524  Platinum drug resistance
pcrs04012  ErbB signaling pathway
pcrs04014  Ras signaling pathway
pcrs04015  Rap1 signaling pathway
pcrs04024  cAMP signaling pathway
pcrs04062  Chemokine signaling pathway
pcrs04066  HIF-1 signaling pathway
pcrs04068  FoxO signaling pathway
pcrs04070  Phosphatidylinositol signaling system
pcrs04071  Sphingolipid signaling pathway
pcrs04072  Phospholipase D signaling pathway
pcrs04081  Hormone signaling
pcrs04140  Autophagy - animal
pcrs04145  Phagocytosis
pcrs04150  mTOR signaling pathway
pcrs04151  PI3K-Akt signaling pathway
pcrs04152  AMPK signaling pathway
pcrs04210  Apoptosis
pcrs04211  Longevity regulating pathway
pcrs04213  Longevity regulating pathway - multiple species
pcrs04218  Cellular senescence
pcrs04360  Axon guidance
pcrs04370  VEGF signaling pathway
pcrs04380  Osteoclast differentiation
pcrs04510  Focal adhesion
pcrs04517  IgSF CAM signaling
pcrs04518  Integrin signaling
pcrs04550  Signaling pathways regulating pluripotency of stem cells
pcrs04611  Platelet activation
pcrs04613  Neutrophil extracellular trap formation
pcrs04620  Toll-like receptor signaling pathway
pcrs04625  C-type lectin receptor signaling pathway
pcrs04630  JAK-STAT signaling pathway
pcrs04650  Natural killer cell mediated cytotoxicity
pcrs04660  T cell receptor signaling pathway
pcrs04662  B cell receptor signaling pathway
pcrs04664  Fc epsilon RI signaling pathway
pcrs04666  Fc gamma R-mediated phagosome formation
pcrs04668  TNF signaling pathway
pcrs04670  Leukocyte transendothelial migration
pcrs04722  Neurotrophin signaling pathway
pcrs04725  Cholinergic synapse
pcrs04750  Inflammatory mediator regulation of TRP channels
pcrs04810  Regulation of actin cytoskeleton
pcrs04910  Insulin signaling pathway
pcrs04914  Progesterone-mediated oocyte maturation
pcrs04915  Estrogen signaling pathway
pcrs04917  Prolactin signaling pathway
pcrs04919  Thyroid hormone signaling pathway
pcrs04923  Regulation of lipolysis in adipocytes
pcrs04926  Relaxin signaling pathway
pcrs04929  GnRH secretion
pcrs04930  Type II diabetes mellitus
pcrs04931  Insulin resistance
pcrs04932  Non-alcoholic fatty liver disease
pcrs04933  AGE-RAGE signaling pathway in diabetic complications
pcrs04935  Growth hormone synthesis, secretion and action
pcrs04960  Aldosterone-regulated sodium reabsorption
pcrs04973  Carbohydrate digestion and absorption
pcrs05010  Alzheimer disease
pcrs05017  Spinocerebellar ataxia
pcrs05020  Prion disease
pcrs05100  Bacterial invasion of epithelial cells
pcrs05135  Yersinia infection
pcrs05142  Chagas disease
pcrs05146  Amoebiasis
pcrs05160  Hepatitis C
pcrs05161  Hepatitis B
pcrs05162  Measles
pcrs05163  Human cytomegalovirus infection
pcrs05164  Influenza A
pcrs05165  Human papillomavirus infection
pcrs05166  Human T-cell leukemia virus 1 infection
pcrs05167  Kaposi sarcoma-associated herpesvirus infection
pcrs05168  Herpes simplex virus 1 infection
pcrs05169  Epstein-Barr virus infection
pcrs05170  Human immunodeficiency virus 1 infection
pcrs05171  Coronavirus disease
pcrs05200  Pathways in cancer
pcrs05203  Viral carcinogenesis
pcrs05205  Proteoglycans in cancer
pcrs05206  MicroRNAs in cancer
pcrs05207  Chemical carcinogenesis - receptor activation
pcrs05208  Chemical carcinogenesis - reactive oxygen species
pcrs05210  Colorectal cancer
pcrs05211  Renal cell carcinoma
pcrs05212  Pancreatic cancer
pcrs05213  Endometrial cancer
pcrs05214  Glioma
pcrs05215  Prostate cancer
pcrs05218  Melanoma
pcrs05220  Chronic myeloid leukemia
pcrs05221  Acute myeloid leukemia
pcrs05222  Small cell lung cancer
pcrs05223  Non-small cell lung cancer
pcrs05224  Breast cancer
pcrs05225  Hepatocellular carcinoma
pcrs05226  Gastric cancer
pcrs05230  Central carbon metabolism in cancer
pcrs05231  Choline metabolism in cancer
pcrs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcrs05415  Diabetic cardiomyopathy
pcrs05417  Lipid and atherosclerosis
pcrs05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcrs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    137222266 (PIK3R2)
   04014 Ras signaling pathway
    137222266 (PIK3R2)
   04015 Rap1 signaling pathway
    137222266 (PIK3R2)
   04370 VEGF signaling pathway
    137222266 (PIK3R2)
   04630 JAK-STAT signaling pathway
    137222266 (PIK3R2)
   04668 TNF signaling pathway
    137222266 (PIK3R2)
   04066 HIF-1 signaling pathway
    137222266 (PIK3R2)
   04068 FoxO signaling pathway
    137222266 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    137222266 (PIK3R2)
   04072 Phospholipase D signaling pathway
    137222266 (PIK3R2)
   04071 Sphingolipid signaling pathway
    137222266 (PIK3R2)
   04024 cAMP signaling pathway
    137222266 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    137222266 (PIK3R2)
   04152 AMPK signaling pathway
    137222266 (PIK3R2)
   04150 mTOR signaling pathway
    137222266 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    137222266 (PIK3R2)
   04517 IgSF CAM signaling
    137222266 (PIK3R2)
   04518 Integrin signaling
    137222266 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    137222266 (PIK3R2)
   04140 Autophagy - animal
    137222266 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    137222266 (PIK3R2)
   04218 Cellular senescence
    137222266 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    137222266 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    137222266 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    137222266 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    137222266 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    137222266 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    137222266 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    137222266 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    137222266 (PIK3R2)
   04660 T cell receptor signaling pathway
    137222266 (PIK3R2)
   04662 B cell receptor signaling pathway
    137222266 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    137222266 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    137222266 (PIK3R2)
   04670 Leukocyte transendothelial migration
    137222266 (PIK3R2)
   04062 Chemokine signaling pathway
    137222266 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    137222266 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    137222266 (PIK3R2)
   04929 GnRH secretion
    137222266 (PIK3R2)
   04915 Estrogen signaling pathway
    137222266 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    137222266 (PIK3R2)
   04917 Prolactin signaling pathway
    137222266 (PIK3R2)
   04926 Relaxin signaling pathway
    137222266 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    137222266 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    137222266 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    137222266 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    137222266 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    137222266 (PIK3R2)
   04722 Neurotrophin signaling pathway
    137222266 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    137222266 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    137222266 (PIK3R2)
   04380 Osteoclast differentiation
    137222266 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    137222266 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    137222266 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    137222266 (PIK3R2)
   05206 MicroRNAs in cancer
    137222266 (PIK3R2)
   05205 Proteoglycans in cancer
    137222266 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    137222266 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    137222266 (PIK3R2)
   05203 Viral carcinogenesis
    137222266 (PIK3R2)
   05230 Central carbon metabolism in cancer
    137222266 (PIK3R2)
   05231 Choline metabolism in cancer
    137222266 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    137222266 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    137222266 (PIK3R2)
   05212 Pancreatic cancer
    137222266 (PIK3R2)
   05225 Hepatocellular carcinoma
    137222266 (PIK3R2)
   05226 Gastric cancer
    137222266 (PIK3R2)
   05214 Glioma
    137222266 (PIK3R2)
   05221 Acute myeloid leukemia
    137222266 (PIK3R2)
   05220 Chronic myeloid leukemia
    137222266 (PIK3R2)
   05218 Melanoma
    137222266 (PIK3R2)
   05211 Renal cell carcinoma
    137222266 (PIK3R2)
   05215 Prostate cancer
    137222266 (PIK3R2)
   05213 Endometrial cancer
    137222266 (PIK3R2)
   05224 Breast cancer
    137222266 (PIK3R2)
   05222 Small cell lung cancer
    137222266 (PIK3R2)
   05223 Non-small cell lung cancer
    137222266 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    137222266 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    137222266 (PIK3R2)
   05161 Hepatitis B
    137222266 (PIK3R2)
   05160 Hepatitis C
    137222266 (PIK3R2)
   05171 Coronavirus disease
    137222266 (PIK3R2)
   05164 Influenza A
    137222266 (PIK3R2)
   05162 Measles
    137222266 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    137222266 (PIK3R2)
   05163 Human cytomegalovirus infection
    137222266 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    137222266 (PIK3R2)
   05169 Epstein-Barr virus infection
    137222266 (PIK3R2)
   05165 Human papillomavirus infection
    137222266 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    137222266 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    137222266 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    137222266 (PIK3R2)
   05142 Chagas disease
    137222266 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    137222266 (PIK3R2)
   05017 Spinocerebellar ataxia
    137222266 (PIK3R2)
   05020 Prion disease
    137222266 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    137222266 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    137222266 (PIK3R2)
   05415 Diabetic cardiomyopathy
    137222266 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    137222266 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    137222266 (PIK3R2)
   04931 Insulin resistance
    137222266 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    137222266 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    137222266 (PIK3R2)
   01524 Platinum drug resistance
    137222266 (PIK3R2)
   01522 Endocrine resistance
    137222266 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcrs04131]
    137222266 (PIK3R2)
Membrane trafficking [BR:pcrs04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    137222266 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 ODF2_C Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 137222266
NCBI-ProteinID: XP_067589327
Position
3:160749314..160761661
AA seq 723 aa
MAGAEGFQYRALYPFCRERPEDLELLPGDVLVVSRAALQALGVAEGSERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVTLARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAIERTGLDSYRPEAPAARTDWSLNDMEQWDAAALTDGVKGFLLALPA
PLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHSALTLRFLLQHLGRVARRAPALGPAV
RALSTAFGPLLLRAPSPSPPPGGAPDGTEATPDFPTLLVEKLLQEHLEEQEIAPPALPPK
PPKAKPAPTGLANGGNPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEY
TLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYPV
SKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFN
ETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQE
LRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQY
SLMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDT
KHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPP
ATR
NT seq 2172 nt   +upstreamnt  +downstreamnt
atggctggcgccgagggcttccaataccgtgcgttgtacccgttctgccgggagcggccg
gaggacctggagctgctgccgggcgatgtgctggtggtgagcagggcagccctgcaggcg
ctgggcgtggccgagggcagcgagcgctgcccacagagcgtgggctggatgcctggcctc
aatgagcgtacacggcagcgcggcgacttccctggcacctatgttgagttcctagggcct
gtgaccctggcccggcctgggcctcgcccacgtggtccacgcccactgcctgccaggccc
cgagatgggccccctgagccaggcctcacactccctgacctacccgagcagttctccccg
cctgatgtggctccccctatcctggtgaaacttgtggaggccattgagcggacagggcta
gacagctacaggcctgaggcacccgccgcgcgcacagactggtcgctgaacgatatggag
cagtgggacgctgcagccctaacagatggcgtgaagggcttcctgctggcgctgcccgca
ccccttgtgacacccgaggccgcggctgaggcacaccgagccctgcgggaggccgcgggg
cccgtggggccagcgctggagcccccgacgctgccgctgcacagcgcgctcacactgcgc
ttcctgctccagcacctgggccgggtggcccggcgcgccccagccctgggcccagctgtg
cgtgccctgagcaccgccttcgggccgctgctgctgcgggcgccgtcgccttcgccgccg
ccagggggcgctcccgacgggactgaggccacccccgacttccctacgcttctggtggag
aagttgcttcaggaacatctggaggaacaggagattgcgcccccagcactgccgccaaaa
ccccccaaggcaaagccagcccccacaggcctggccaatgggggcaacccgccctccctg
caggatgctgagtggtactggggtgacatctccagggaggaggtaaatgagaaactgcgg
gacacacctgatggcacctttctggtccgagatgcatctagcaagatccagggggagtac
acgctgaccctcaggaaaggtgggaacaacaaactgatcaaggtcttccaccgagacggg
cactacggcttttcggagccactcaccttctgctctgtcgtggacctcatcacccactac
cgccacgagtcgctggctcagtacaacgccaagctggacacgcggctcctctacccggtg
tccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaagcagtgggcgcccag
ctcaaggtctaccaccagcagtaccaggacaagagccgcgagtatgaccagctctacgag
gagtacacacgcacctcccaggaactgcagatgaagcgcacagccattgaggccttcaat
gagactatcaagatctttgaagagcagggccagacacaggagaagtgcagcaaggaatat
ctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatcctgctgaactca
gagcgacttaagtctcgtattgctgagatccacgagagccgcacaaagctggaacaggag
ctgcgggcacaggcctccgacaaccgagagattgacaagcgcatgaacagcctcaagcca
gacctcatgcagctgcgcaagatcagagaccagtacctcgtgtggctcactcagaaaggt
gcccggcagaagaaaatcaatgaatggttggggatcaagaacgagactgaggaccagtac
tcactgatggaggatgaagatgatctcccccaccacgaggaacgcacatggtatgtaggc
aagatcaaccgcacccaagctgaggaaatgctgagtggcaagcgagatggcaccttcctc
atccgtgaaagcagccagcggggctgctatgcctgttctgtggtggtagacggtgacacc
aaacactgcgtcatctaccgcacagccacgggctttggcttcgcagaaccctacaacttg
tatgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctggtgcagcacaac
gacgcgctcaccgtcacacttgcccatcctgtgcgcgccccgggccccgggcccccacct
gccacccgctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (9)   
   Pfam (9)   
All databases (23)   

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