KEGG   Phascolarctos cinereus (koala): 110208219
Entry
110208219         CDS       T05867                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw00562  Inositol phosphate metabolism
pcw01100  Metabolic pathways
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw01522  Endocrine resistance
pcw01524  Platinum drug resistance
pcw04012  ErbB signaling pathway
pcw04014  Ras signaling pathway
pcw04015  Rap1 signaling pathway
pcw04024  cAMP signaling pathway
pcw04062  Chemokine signaling pathway
pcw04066  HIF-1 signaling pathway
pcw04068  FoxO signaling pathway
pcw04070  Phosphatidylinositol signaling system
pcw04071  Sphingolipid signaling pathway
pcw04072  Phospholipase D signaling pathway
pcw04081  Hormone signaling
pcw04140  Autophagy - animal
pcw04145  Phagocytosis
pcw04150  mTOR signaling pathway
pcw04151  PI3K-Akt signaling pathway
pcw04152  AMPK signaling pathway
pcw04210  Apoptosis
pcw04211  Longevity regulating pathway
pcw04213  Longevity regulating pathway - multiple species
pcw04218  Cellular senescence
pcw04360  Axon guidance
pcw04370  VEGF signaling pathway
pcw04380  Osteoclast differentiation
pcw04510  Focal adhesion
pcw04517  IgSF CAM signaling
pcw04518  Integrin signaling
pcw04550  Signaling pathways regulating pluripotency of stem cells
pcw04611  Platelet activation
pcw04613  Neutrophil extracellular trap formation
pcw04620  Toll-like receptor signaling pathway
pcw04625  C-type lectin receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
pcw04650  Natural killer cell mediated cytotoxicity
pcw04660  T cell receptor signaling pathway
pcw04662  B cell receptor signaling pathway
pcw04664  Fc epsilon RI signaling pathway
pcw04666  Fc gamma R-mediated phagosome formation
pcw04668  TNF signaling pathway
pcw04670  Leukocyte transendothelial migration
pcw04722  Neurotrophin signaling pathway
pcw04725  Cholinergic synapse
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04810  Regulation of actin cytoskeleton
pcw04910  Insulin signaling pathway
pcw04914  Progesterone-mediated oocyte maturation
pcw04915  Estrogen signaling pathway
pcw04917  Prolactin signaling pathway
pcw04919  Thyroid hormone signaling pathway
pcw04923  Regulation of lipolysis in adipocytes
pcw04926  Relaxin signaling pathway
pcw04929  GnRH secretion
pcw04930  Type II diabetes mellitus
pcw04931  Insulin resistance
pcw04932  Non-alcoholic fatty liver disease
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04935  Growth hormone synthesis, secretion and action
pcw04960  Aldosterone-regulated sodium reabsorption
pcw04973  Carbohydrate digestion and absorption
pcw05010  Alzheimer disease
pcw05017  Spinocerebellar ataxia
pcw05020  Prion disease
pcw05100  Bacterial invasion of epithelial cells
pcw05132  Salmonella infection
pcw05135  Yersinia infection
pcw05142  Chagas disease
pcw05146  Amoebiasis
pcw05160  Hepatitis C
pcw05161  Hepatitis B
pcw05162  Measles
pcw05163  Human cytomegalovirus infection
pcw05164  Influenza A
pcw05165  Human papillomavirus infection
pcw05166  Human T-cell leukemia virus 1 infection
pcw05167  Kaposi sarcoma-associated herpesvirus infection
pcw05168  Herpes simplex virus 1 infection
pcw05169  Epstein-Barr virus infection
pcw05170  Human immunodeficiency virus 1 infection
pcw05171  Coronavirus disease
pcw05200  Pathways in cancer
pcw05203  Viral carcinogenesis
pcw05205  Proteoglycans in cancer
pcw05206  MicroRNAs in cancer
pcw05207  Chemical carcinogenesis - receptor activation
pcw05208  Chemical carcinogenesis - reactive oxygen species
pcw05210  Colorectal cancer
pcw05211  Renal cell carcinoma
pcw05212  Pancreatic cancer
pcw05213  Endometrial cancer
pcw05214  Glioma
pcw05215  Prostate cancer
pcw05218  Melanoma
pcw05220  Chronic myeloid leukemia
pcw05221  Acute myeloid leukemia
pcw05222  Small cell lung cancer
pcw05223  Non-small cell lung cancer
pcw05224  Breast cancer
pcw05225  Hepatocellular carcinoma
pcw05226  Gastric cancer
pcw05230  Central carbon metabolism in cancer
pcw05231  Choline metabolism in cancer
pcw05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
pcw05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110208219 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110208219 (PIK3CB)
   04014 Ras signaling pathway
    110208219 (PIK3CB)
   04015 Rap1 signaling pathway
    110208219 (PIK3CB)
   04370 VEGF signaling pathway
    110208219 (PIK3CB)
   04630 JAK-STAT signaling pathway
    110208219 (PIK3CB)
   04668 TNF signaling pathway
    110208219 (PIK3CB)
   04066 HIF-1 signaling pathway
    110208219 (PIK3CB)
   04068 FoxO signaling pathway
    110208219 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    110208219 (PIK3CB)
   04072 Phospholipase D signaling pathway
    110208219 (PIK3CB)
   04071 Sphingolipid signaling pathway
    110208219 (PIK3CB)
   04024 cAMP signaling pathway
    110208219 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    110208219 (PIK3CB)
   04152 AMPK signaling pathway
    110208219 (PIK3CB)
   04150 mTOR signaling pathway
    110208219 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110208219 (PIK3CB)
   04517 IgSF CAM signaling
    110208219 (PIK3CB)
   04518 Integrin signaling
    110208219 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    110208219 (PIK3CB)
   04140 Autophagy - animal
    110208219 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    110208219 (PIK3CB)
   04218 Cellular senescence
    110208219 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110208219 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    110208219 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110208219 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110208219 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    110208219 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    110208219 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    110208219 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    110208219 (PIK3CB)
   04660 T cell receptor signaling pathway
    110208219 (PIK3CB)
   04662 B cell receptor signaling pathway
    110208219 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    110208219 (PIK3CB)
   04666 Fc gamma R-mediated phagosome formation
    110208219 (PIK3CB)
   04670 Leukocyte transendothelial migration
    110208219 (PIK3CB)
   04062 Chemokine signaling pathway
    110208219 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110208219 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    110208219 (PIK3CB)
   04929 GnRH secretion
    110208219 (PIK3CB)
   04915 Estrogen signaling pathway
    110208219 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    110208219 (PIK3CB)
   04917 Prolactin signaling pathway
    110208219 (PIK3CB)
   04926 Relaxin signaling pathway
    110208219 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    110208219 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    110208219 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110208219 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110208219 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    110208219 (PIK3CB)
   04722 Neurotrophin signaling pathway
    110208219 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110208219 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    110208219 (PIK3CB)
   04380 Osteoclast differentiation
    110208219 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    110208219 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    110208219 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110208219 (PIK3CB)
   05206 MicroRNAs in cancer
    110208219 (PIK3CB)
   05205 Proteoglycans in cancer
    110208219 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    110208219 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    110208219 (PIK3CB)
   05203 Viral carcinogenesis
    110208219 (PIK3CB)
   05230 Central carbon metabolism in cancer
    110208219 (PIK3CB)
   05231 Choline metabolism in cancer
    110208219 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110208219 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110208219 (PIK3CB)
   05212 Pancreatic cancer
    110208219 (PIK3CB)
   05225 Hepatocellular carcinoma
    110208219 (PIK3CB)
   05226 Gastric cancer
    110208219 (PIK3CB)
   05214 Glioma
    110208219 (PIK3CB)
   05221 Acute myeloid leukemia
    110208219 (PIK3CB)
   05220 Chronic myeloid leukemia
    110208219 (PIK3CB)
   05218 Melanoma
    110208219 (PIK3CB)
   05211 Renal cell carcinoma
    110208219 (PIK3CB)
   05215 Prostate cancer
    110208219 (PIK3CB)
   05213 Endometrial cancer
    110208219 (PIK3CB)
   05224 Breast cancer
    110208219 (PIK3CB)
   05222 Small cell lung cancer
    110208219 (PIK3CB)
   05223 Non-small cell lung cancer
    110208219 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110208219 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    110208219 (PIK3CB)
   05161 Hepatitis B
    110208219 (PIK3CB)
   05160 Hepatitis C
    110208219 (PIK3CB)
   05171 Coronavirus disease
    110208219 (PIK3CB)
   05164 Influenza A
    110208219 (PIK3CB)
   05162 Measles
    110208219 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    110208219 (PIK3CB)
   05163 Human cytomegalovirus infection
    110208219 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110208219 (PIK3CB)
   05169 Epstein-Barr virus infection
    110208219 (PIK3CB)
   05165 Human papillomavirus infection
    110208219 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110208219 (PIK3CB)
   05135 Yersinia infection
    110208219 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    110208219 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110208219 (PIK3CB)
   05142 Chagas disease
    110208219 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110208219 (PIK3CB)
   05017 Spinocerebellar ataxia
    110208219 (PIK3CB)
   05020 Prion disease
    110208219 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110208219 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    110208219 (PIK3CB)
   05415 Diabetic cardiomyopathy
    110208219 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110208219 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    110208219 (PIK3CB)
   04931 Insulin resistance
    110208219 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110208219 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110208219 (PIK3CB)
   01524 Platinum drug resistance
    110208219 (PIK3CB)
   01522 Endocrine resistance
    110208219 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcw04131]
    110208219 (PIK3CB)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     110208219 (PIK3CB)
Membrane trafficking [BR:pcw04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110208219 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 LepB_N
Other DBs
NCBI-GeneID: 110208219
NCBI-ProteinID: XP_020841785
UniProt: A0A6P5KAG0
Position
Unknown
AA seq 1069 aa
MCFSFIMPPAMADILDFWGVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISNIKQMLW
KQAHNYPMFNLLMEIEAYMFACVNQTAVYEELEDETRRLCDIRPFLSVLKVVTRNCDPGE
KLDSKIGVLIGKGLHEFDALEDPEVNEFRSKMRQFSEEKIQSLVGLSWMDWLKHTYPPEQ
EPSIPENLEDKLYGGNLVVAVHFENCQDVFSFQVSPNMNPIKLNELAIRKRLTIRGKEDE
VDPYDYVLQVSGRLEYVFGDHPLIQFQYIRNCVMNRTLPKLTLVECCNIKKMCEQEMIAI
EAAINRNSSNLPLPLPPKKTRLISNVWENTQPFQIILVKGTKLNTEETVKVHVRAGLFHG
TELLCKPVVSSEISGRNDRVWSEPLEFDINICDLPRMARLCFAVYAVDKVKTKKSTKTIN
PSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLKAGDIILHSWSSFPDELEEMLNPMGTVQT
NPYIENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSGNVSSRGGKKFHAVLKEI
MERDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSVKWNKLEDVAQLQALLQIWPKL
PPREALELLDFNYPDQYVREYAVSCLKQMSDEELSQYLLQLVQVLKYEPFLDCALSRFML
DRALANRRIGQFLFWHLRSEVHIPAFSVQFGVILEAYCRGSVGYMKVLSKQVEALNKLKT
LNSLIKLNAVKLNKAKGREAMHTCLKQNAYREALSDLPSPLNPCVILSELYVEKCKYMDS
KMKPLRIVYNNKVFGGDPVGIIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGC
LATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDQAIEEF
TLSCAGYCVASYVLGIGDRHSDNIMVRKTGQLFHIDFGHILGNFKSKFGIKRERVPFILT
YDFIHVIQQGKTGNTEKFNRFRKCCEEAYLILRRHGNLFITLFALMLTAGLPELTSVKDI
QYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTMRKDYRS
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgtgcttcagttttataatgcctcctgctatggcagacatccttgacttttggggcgtg
gattctcagatagcatcagatggctccattcctgtggattttttattgcccactgggatc
tatatccaattggaagtacctcgggaggccactatttctaatattaaacagatgctatgg
aagcaagctcacaactatcctatgtttaaccttcttatggaaattgaagcttatatgttt
gcatgtgtgaaccagactgctgtttatgaggagcttgaagatgaaacaagaagactttgt
gatatcagaccttttctttcagttctcaaagtggtgacaagaaattgtgacccaggggaa
aaattagattccaaaattggagttcttataggaaaaggtcttcatgagtttgatgcccta
gaagatcccgaagtgaatgagttccgaagtaaaatgcgccagttcagtgaagaaaagatc
cagtcccttgtggggttgtcttggatggattggttaaagcatacttacccaccagaacaa
gaaccttctattcctgaaaacttggaagataaactttatggtggaaatcttgtggtagct
gtccattttgaaaattgtcaggatgtatttagtttccaagtatctcctaatatgaatccc
atcaagctaaatgagttagcaatccgaaaacggttgactatccgtggaaaggaagatgaa
gttgatccttatgactatgtgctacaagtcagtgggagactagaatatgtgtttggtgat
cacccattaattcagttccagtatatacggaactgtgtcatgaatagaactcttcccaaa
ctcactcttgttgaatgttgcaatatcaagaagatgtgtgaacaggaaatgattgccata
gaagctgccataaatcgaaattcatccaaccttcctcttccactgccaccaaaaaaaaca
cgattaatttctaatgtttgggagaatacccagcctttccaaattatattggttaagggg
actaaactgaacacagaagaaactgtcaaagttcatgtcagggctggactttttcatgga
actgaacttctttgcaaaccggttgtaagctcagagatatctgggagaaatgaccgtgtt
tggagtgaaccactggaatttgatattaacatctgtgatttaccaagaatggctcggtta
tgctttgcagtttatgctgtagataaagtgaaaacaaaaaagtcgaccaagacaattaat
ccctccaaatatcagactatcaggaaagctggaaaagtgcactatcctgtagcatgggta
aataccatggtgtttgactttaaaggacagctgaaagctggagatatcatattgcacagc
tggtcatcatttcctgatgagcttgaagaaatgttgaatccaatgggaactgttcaaaca
aatccatatattgaaaatgcaacagctttacatgttaaattccctgagaataaaaagcag
ccttattattaccctccctttgataagattattgagaaggcagctgagattgcaagtagt
gacagtggtaacgtatcaagtcgaggtggaaaaaaatttcatgctgtgctcaaagaaatc
atggagagggatcccttatcccaactgtgtgaaaatgaaatggatcttatttggactttg
agacaagactgtagagaaaattttccacagtcattgccaaaattgctgctgtctgtcaaa
tggaataaacttgaagatgttgctcagctacaggctcttcttcagatatggcctaaactg
cctcctagagaagcattggaattattagactttaattatccagaccagtatgtaagagag
tatgcagtgagctgcttgaaacaaatgagtgacgaagaactatctcagtacctcctacaa
cttgtacaagttttgaaatacgaaccttttcttgattgtgccctatctagattcatgtta
gacagagcacttgctaataggaggatagggcagtttctattttggcatcttaggtcagaa
gtacacattcctgccttttcagtacaatttggtgtaatacttgaagcttactgtcgagga
agtgtgggctatatgaaagtgctttctaaacaggttgaagctctaaataagctgaagacc
ttaaatagtttaataaaattgaacgcagtaaaattaaacaaagcaaaaggaagagaggca
atgcacacatgcttaaaacaaaatgcttaccgagaagccctttctgatcttccgtcacct
ttgaatccttgtgtcatactctcagaactttatgttgagaagtgcaagtacatggattct
aaaatgaagcctctgagaatagtatacaacaacaaagtatttggaggagatccagtgggt
atcattttcaaaaatggggatgatctacggcaagatatgttgactctccaaatgttgcgg
ttgatggatttactttggaaagaggctggattggatctccgaatgctgccgtatggttgt
ttagcaacaggagaccgctctggccttatagaagttgttagtacatctgaaacaattgcc
gatatccagctaaatagtagtaatgttgctgctacagctgccttcaataaagatgctctt
ctaaattggcttaaagaatacaattctggggatgacttagatcaagccattgaagagttc
acactctcctgtgctggctactgtgtagcttcttatgtcctggggatcggtgatagacac
agtgacaacatcatggtcaggaaaactggacagctcttccacatcgattttggacatatt
cttggaaacttcaagtctaaatttggcattaaacgggaacgagtgcctttcattcttacc
tatgatttcattcatgtcattcagcaaggaaaaacaggaaacacagaaaagtttaaccgg
ttccgtaagtgttgtgaagaggcttacctgattttacgaaggcatgggaatctctttatc
actctgtttgccctgatgttgactgcagggcttcctgagctcacctcagttaaggatata
cagtatcttaaggactctttggccttggggaagagtgaggaagaagcactaaagcagttt
aagcagaaatttgatgaggcgctcagggagagttggactactaaagtaaactggatggcg
cacaccatgaggaaagattaccggtcttaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (7)   
   Pfam (7)   
All databases (20)   

Download RDF
DBGET integrated database retrieval system