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Database: PDB
Entry: 1BU9
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Original site: 1BU9 
HEADER    HORMONE/GROWTH FACTOR                   15-SEP-98   1BU9              
TITLE     SOLUTION STRUCTURE OF P18-INK4C, 21 STRUCTURES                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEIN (CYCLIN-DEPENDENT KINASE 6 INHIBITOR);             
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: P18-INK4C;                                                  
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: DL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: DL21(DE3)                                 
KEYWDS    CELL CYCLE INHIBITOR, P18INK4C, TUMOR, SUPPRESSOR, CYCLIN-            
KEYWDS   2 DEPENDENT KINASE, HORMONE/GROWTH FACTOR COMPLEX                      
EXPDTA    SOLUTION NMR                                                          
NUMMDL    21                                                                    
AUTHOR    I.-J.L.BYEON,J.LI,M.-D.TSAI                                           
REVDAT   3   24-FEB-09 1BU9    1       VERSN                                    
REVDAT   2   01-APR-03 1BU9    1       JRNL                                     
REVDAT   1   13-SEP-99 1BU9    0                                                
JRNL        AUTH   J.LI,I.J.BYEON,K.ERICSON,M.J.POI,P.O'MAILLE,                 
JRNL        AUTH 2 T.SELBY,M.D.TSAI                                             
JRNL        TITL   TUMOR SUPPRESSOR INK4: DETERMINATION OF THE                  
JRNL        TITL 2 SOLUTION STRUCTURE OF P18INK4C AND DEMONSTRATION             
JRNL        TITL 3 OF THE FUNCTIONAL SIGNIFICANCE OF LOOPS IN                   
JRNL        TITL 4 P18INK4C AND P16INK4A.                                       
JRNL        REF    BIOCHEMISTRY                  V.  38  2930 1999              
JRNL        REFN                   ISSN 0006-2960                               
JRNL        PMID   10074345                                                     
JRNL        DOI    10.1021/BI982286E                                            
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : X-PLOR                                               
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1BU9 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-JUL-99.                  
REMARK 100 THE RCSB ID CODE IS RCSB007107.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 293                                
REMARK 210  PH                             : 7.5                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : HNCACB, CBCA(CO)HN, HN(CO)         
REMARK 210                                   HCCH-TOCSY, HNHB, 3D 15N-          
REMARK 210                                   EDITED NOESY AND TOCSY, 2D         
REMARK 210                                   NOESY AND TOCSY, 3D 13C-EDITED     
REMARK 210                                   NOESY, 3D 15N/13C SA EDITED        
REMARK 210                                   NOESY, 4D 15N/13C-EDITED           
REMARK 210                                   NOESY, 4D 13C/13C-EDITED NOES      
REMARK 210  SPECTROMETER FIELD STRENGTH    : 600 MHZ, 800 MHZ                   
REMARK 210  SPECTROMETER MODEL             : DMX600, DRX800                     
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : X-PLOR                             
REMARK 210   METHOD USED                   : SIMULATED ANNEALING                
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 50                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 21                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : CLOSEST TO MEAN STRUCTURE          
REMARK 210                                   WHICH SHOWS GOOD AGREEMENT         
REMARK 210                                   WITH THE CONSTRAINTS               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: THE SOLUTION STRUCTURE OF P18-INK4C HAS BEEN DETERMINED      
REMARK 210  BY MULTI-DIMENSIONAL HETERONUCLEAR NMR. THE STRUCTURES WERE         
REMARK 210  CALCULATED USING THE SIMULATED ANNEALING PROTOCOL OF NILGES ET      
REMARK 210  AL. (1988) FEBS LETT. 229, 129-136 USING THE PROGRAM X-PLOR         
REMARK 210  3.1 (BRUNGER). THE CALCULATION IS BASED ON 3175 EXPERIMENTAL        
REMARK 210  NMR RESTRAINTS (3062 DISTANCE AND 113 TORSION ANGLE                 
REMARK 210  RESTRAINTS).                                                        
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 ALA A   2       51.72   -110.81                                   
REMARK 500  1 TRP A   5     -152.51     52.39                                   
REMARK 500  1 ASN A   7      -71.84    -53.45                                   
REMARK 500  1 LEU A   9      -78.78    -62.75                                   
REMARK 500  1 SER A  11      -83.00    -67.64                                   
REMARK 500  1 ASP A  17       98.06    -54.93                                   
REMARK 500  1 ASN A  28      139.16   -176.13                                   
REMARK 500  1 ASN A  30       85.84    -62.49                                   
REMARK 500  1 VAL A  31      -27.04    -37.70                                   
REMARK 500  1 ALA A  33      178.37    -49.70                                   
REMARK 500  1 GLN A  34       98.78   -174.91                                   
REMARK 500  1 ASN A  35      170.13    -53.23                                   
REMARK 500  1 MET A  45      112.38      2.60                                   
REMARK 500  1 LYS A  46       93.23    -42.00                                   
REMARK 500  1 LEU A  65       78.06    -63.22                                   
REMARK 500  1 LYS A  66      172.67    -52.41                                   
REMARK 500  1 ASP A  67     -142.06   -127.96                                   
REMARK 500  1 ASP A  95       88.35    -47.43                                   
REMARK 500  1 GLU A  99     -149.30   -128.28                                   
REMARK 500  1 ASP A 100     -155.58   -113.10                                   
REMARK 500  1 ASN A 101       38.38    -89.98                                   
REMARK 500  1 GLU A 102      -54.03   -163.66                                   
REMARK 500  1 ASN A 104      150.10    -48.60                                   
REMARK 500  1 HIS A 115       69.73    -65.48                                   
REMARK 500  1 LEU A 116      -79.24    -52.04                                   
REMARK 500  1 ARG A 117      -30.32    -39.55                                   
REMARK 500  1 HIS A 125     -137.79   -126.01                                   
REMARK 500  1 THR A 126     -161.42     37.42                                   
REMARK 500  1 SER A 128      161.65     52.56                                   
REMARK 500  1 ASN A 129       53.51   -119.39                                   
REMARK 500  1 VAL A 130      -78.93    -50.13                                   
REMARK 500  1 HIS A 132       76.76    -61.14                                   
REMARK 500  1 ASN A 134     -152.53    -55.90                                   
REMARK 500  1 ASP A 138       87.50    -66.43                                   
REMARK 500  1 THR A 139     -166.39    -61.27                                   
REMARK 500  1 LEU A 143      -68.41    -92.91                                   
REMARK 500  1 ARG A 149      100.73    -39.33                                   
REMARK 500  1 ASN A 159       44.80    -81.79                                   
REMARK 500  1 ALA A 164       71.83     41.93                                   
REMARK 500  1 THR A 165       62.62   -101.19                                   
REMARK 500  2 ALA A   2       76.09   -161.40                                   
REMARK 500  2 GLU A   3       61.62     33.93                                   
REMARK 500  2 TRP A   5       89.79     62.71                                   
REMARK 500  2 SER A  11      -75.76    -63.40                                   
REMARK 500  2 THR A  22      -70.04    -62.19                                   
REMARK 500  2 ASN A  28      140.68   -179.77                                   
REMARK 500  2 ASN A  30       75.24   -105.71                                   
REMARK 500  2 ALA A  33     -166.89    -53.55                                   
REMARK 500  2 GLN A  34      113.82   -170.88                                   
REMARK 500  2 MET A  45      118.07     -8.31                                   
REMARK 500  2 LYS A  46      -28.54    -36.71                                   
REMARK 500  2 LEU A  47      -33.93     71.01                                   
REMARK 500  2 ILE A  52      -75.27    -44.17                                   
REMARK 500  2 LEU A  65       98.69    -43.40                                   
REMARK 500  2 ASP A  67     -146.85   -128.58                                   
REMARK 500  2 GLN A  93      -81.04     77.88                                   
REMARK 500  2 ALA A  94     -118.21     42.77                                   
REMARK 500  2 ASP A  95       96.09    164.39                                   
REMARK 500  2 GLU A  99     -155.46   -119.64                                   
REMARK 500  2 ASP A 100     -155.45   -121.42                                   
REMARK 500  2 GLU A 102       -1.28   -143.44                                   
REMARK 500  2 HIS A 115       72.31    -62.26                                   
REMARK 500  2 LEU A 116      -89.93    -40.12                                   
REMARK 500  2 ARG A 117      -32.91    -38.66                                   
REMARK 500  2 HIS A 125       -1.72     73.47                                   
REMARK 500  2 SER A 128      112.65     45.07                                   
REMARK 500  2 VAL A 130      -94.43    -46.10                                   
REMARK 500  2 HIS A 132       80.10    -57.41                                   
REMARK 500  2 ASN A 134     -156.12    -55.80                                   
REMARK 500  2 ASP A 138       82.78    -69.67                                   
REMARK 500  2 THR A 139     -172.88    -54.01                                   
REMARK 500  2 LEU A 143      -71.48    -88.32                                   
REMARK 500  2 ARG A 149       87.82    -62.45                                   
REMARK 500  2 ASN A 159       40.46    -83.80                                   
REMARK 500  2 ALA A 161      -44.89    172.64                                   
REMARK 500  2 THR A 165      -28.55   -178.65                                   
REMARK 500  2 ASN A 166     -165.99     52.42                                   
REMARK 500  3 GLU A   3       62.07   -158.12                                   
REMARK 500  3 PRO A   4       48.49    -86.92                                   
REMARK 500  3 TRP A   5      144.17   -177.99                                   
REMARK 500  3 SER A  11      -73.38    -61.78                                   
REMARK 500  3 ASP A  17       91.03    -65.84                                   
REMARK 500  3 ASN A  28      145.42    175.42                                   
REMARK 500  3 ALA A  33     -171.74    -51.68                                   
REMARK 500  3 MET A  45      118.29     -5.84                                   
REMARK 500  3 LYS A  46       93.91    -47.03                                   
REMARK 500  3 ASN A  62      107.30    -55.91                                   
REMARK 500  3 LEU A  65      100.08    -39.35                                   
REMARK 500  3 ASP A  67     -139.02   -116.88                                   
REMARK 500  3 PHE A  92       30.86    -91.83                                   
REMARK 500  3 GLU A  99     -155.28    -83.38                                   
REMARK 500  3 ASP A 100     -144.70   -115.85                                   
REMARK 500  3 GLU A 102      -43.60   -154.96                                   
REMARK 500  3 LEU A 109      -73.62    -72.98                                   
REMARK 500  3 HIS A 115       74.78    -61.37                                   
REMARK 500  3 LEU A 116      -86.16    -44.32                                   
REMARK 500  3 ARG A 117      -36.17    -36.52                                   
REMARK 500  3 HIS A 125      -60.69     69.87                                   
REMARK 500  3 SER A 128      152.04     57.94                                   
REMARK 500  3 VAL A 130     -102.42    -51.17                                   
REMARK 500  3 ASN A 134     -148.55    -58.27                                   
REMARK 500  3 ASP A 138       89.38    -63.86                                   
REMARK 500  3 THR A 139     -177.90    -56.22                                   
REMARK 500  3 LEU A 143      -60.17    -94.18                                   
REMARK 500  3 ASN A 159       45.47    -83.27                                   
REMARK 500  3 ALA A 161      -39.49    176.72                                   
REMARK 500  3 ALA A 164       99.02    -51.58                                   
REMARK 500  3 THR A 165     -155.61    -92.85                                   
REMARK 500  4 GLU A   3       68.93   -155.11                                   
REMARK 500  4 TRP A   5       99.49     47.12                                   
REMARK 500  4 SER A  11      -80.16    -57.93                                   
REMARK 500  4 ASN A  27      -63.53   -105.56                                   
REMARK 500  4 ASN A  28      140.03   -179.64                                   
REMARK 500  4 ALA A  33     -164.54    -53.75                                   
REMARK 500  4 GLN A  34      117.05   -174.22                                   
REMARK 500  4 MET A  45       26.38     24.87                                   
REMARK 500  4 LYS A  46      -59.59     56.22                                   
REMARK 500  4 LEU A  47      -16.59     86.34                                   
REMARK 500  4 LEU A  65       92.92    -30.35                                   
REMARK 500  4 ASP A  67     -144.66   -109.21                                   
REMARK 500  4 ASP A  76      -38.04    -39.64                                   
REMARK 500  4 PHE A  82       79.46   -112.29                                   
REMARK 500  4 PHE A  92       33.55    -94.44                                   
REMARK 500  4 ASP A  95       96.31    -32.78                                   
REMARK 500  4 GLU A  99     -160.26    -74.63                                   
REMARK 500  4 ASP A 100     -144.18   -111.64                                   
REMARK 500  4 GLU A 102      -47.49   -161.66                                   
REMARK 500  4 HIS A 108      -79.23    -48.20                                   
REMARK 500  4 HIS A 115       71.29    -63.49                                   
REMARK 500  4 LEU A 116      -78.26    -50.91                                   
REMARK 500  4 ARG A 117      -29.80    -39.93                                   
REMARK 500  4 VAL A 118      -71.28    -72.53                                   
REMARK 500  4 HIS A 125      -61.66     65.57                                   
REMARK 500  4 SER A 128      166.82     53.75                                   
REMARK 500  4 HIS A 132       24.51     44.37                                   
REMARK 500  4 ASN A 134     -146.39    -59.12                                   
REMARK 500  4 ASP A 138      103.02    -58.80                                   
REMARK 500  4 ALA A 140        0.12    -65.92                                   
REMARK 500  4 LEU A 143      -74.28    -86.06                                   
REMARK 500  4 ARG A 149      107.36    -49.39                                   
REMARK 500  4 ASN A 159       40.00    -79.69                                   
REMARK 500  4 ALA A 161       18.07   -158.07                                   
REMARK 500  5 GLU A   3       78.25     26.14                                   
REMARK 500  5 TRP A   5     -145.68   -168.96                                   
REMARK 500  5 LEU A   9      -71.75    -58.56                                   
REMARK 500  5 SER A  11      -84.46    -55.17                                   
REMARK 500  5 ASN A  27      -77.72    -82.56                                   
REMARK 500  5 ASN A  28      132.04    165.55                                   
REMARK 500  5 VAL A  29      108.22   -169.25                                   
REMARK 500  5 ASN A  30       93.00    -41.77                                   
REMARK 500  5 ALA A  33      176.55    -43.38                                   
REMARK 500  5 MET A  45      120.53     -3.14                                   
REMARK 500  5 LYS A  46       91.42    -50.77                                   
REMARK 500  5 GLU A  51      -29.65    -39.43                                   
REMARK 500  5 LEU A  65       90.50    -50.68                                   
REMARK 500  5 ASP A  67     -149.44   -119.99                                   
REMARK 500  5 ASP A  95       94.11    -43.84                                   
REMARK 500  5 GLU A  99     -143.56    -76.60                                   
REMARK 500  5 ASP A 100     -143.67   -135.43                                   
REMARK 500  5 GLU A 102      -40.03   -152.27                                   
REMARK 500  5 HIS A 115       68.43    -64.56                                   
REMARK 500  5 LEU A 116      -81.60    -45.50                                   
REMARK 500  5 ARG A 117      -31.53    -38.32                                   
REMARK 500  5 HIS A 125      -66.38   -149.45                                   
REMARK 500  5 THR A 126     -172.58    -58.10                                   
REMARK 500  5 SER A 128      174.22     51.35                                   
REMARK 500  5 VAL A 130       79.56    -46.25                                   
REMARK 500  5 HIS A 132       62.66    -65.96                                   
REMARK 500  5 ASN A 134     -156.87    -55.66                                   
REMARK 500  5 ASP A 138       87.61    -67.53                                   
REMARK 500  5 THR A 139     -178.32    -55.48                                   
REMARK 500  5 ALA A 140       -7.65    -58.37                                   
REMARK 500  5 LEU A 143      -64.49    -92.99                                   
REMARK 500  5 ARG A 149       95.68    -67.54                                   
REMARK 500  5 ASN A 159       39.71    -86.18                                   
REMARK 500  5 ALA A 161      -35.45   -177.52                                   
REMARK 500  5 ALA A 164     -175.72     48.44                                   
REMARK 500  5 LEU A 167       71.64    -65.30                                   
REMARK 500  6 TRP A   5      134.36     64.82                                   
REMARK 500  6 ASN A   7      -69.14   -124.32                                   
REMARK 500  6 SER A  11      -78.46    -71.84                                   
REMARK 500  6 ASN A  28      132.59   -176.57                                   
REMARK 500  6 VAL A  31      -26.58    -38.38                                   
REMARK 500  6 ALA A  33      178.58    -47.67                                   
REMARK 500  6 GLN A  34      107.42   -175.98                                   
REMARK 500  6 ASN A  35     -171.81    -67.02                                   
REMARK 500  6 MET A  45      112.11    -28.53                                   
REMARK 500  6 LYS A  46       96.72    -40.39                                   
REMARK 500  6 LEU A  65       89.99    -36.71                                   
REMARK 500  6 ASP A  76      -35.08    -37.57                                   
REMARK 500  6 PHE A  82       73.60   -114.60                                   
REMARK 500  6 PHE A  92       30.92    -89.79                                   
REMARK 500  6 ASP A  95       91.68    -51.75                                   
REMARK 500  6 GLU A  99     -140.62    -81.83                                   
REMARK 500  6 ASP A 100     -147.92   -132.96                                   
REMARK 500  6 ASN A 101       30.40    -90.44                                   
REMARK 500  6 GLU A 102      -44.25   -154.47                                   
REMARK 500  6 PRO A 106       -7.12    -58.75                                   
REMARK 500  6 HIS A 115       73.07    -60.95                                   
REMARK 500  6 LEU A 116      -81.69    -46.83                                   
REMARK 500  6 ARG A 117      -30.17    -39.42                                   
REMARK 500  6 VAL A 118      -70.45    -71.88                                   
REMARK 500  6 HIS A 125     -132.19   -133.01                                   
REMARK 500  6 THR A 126     -172.74     43.12                                   
REMARK 500  6 SER A 128      121.91     52.78                                   
REMARK 500  6 VAL A 130       66.39    -60.70                                   
REMARK 500  6 HIS A 132      149.62    -39.12                                   
REMARK 500  6 ASN A 134     -121.69    -53.80                                   
REMARK 500  6 ASP A 138       98.51    -58.00                                   
REMARK 500  6 THR A 139     -172.47    -63.04                                   
REMARK 500  6 ARG A 149       79.40    -67.95                                   
REMARK 500  6 ASN A 159       43.37    -80.43                                   
REMARK 500  7 ALA A   2       78.33     63.78                                   
REMARK 500  7 GLU A   3       76.21   -171.09                                   
REMARK 500  7 PRO A   4     -159.49    -78.06                                   
REMARK 500  7 TRP A   5     -135.43     68.08                                   
REMARK 500  7 GLU A   8      -63.01    -95.05                                   
REMARK 500  7 LEU A   9      -76.35    -42.94                                   
REMARK 500  7 SER A  11      -80.20    -69.48                                   
REMARK 500  7 ASN A  27      -78.90    -76.58                                   
REMARK 500  7 ASN A  28      123.11    160.20                                   
REMARK 500  7 VAL A  29      103.83   -168.95                                   
REMARK 500  7 ASN A  30       92.53    -39.04                                   
REMARK 500  7 ALA A  33     -160.98    -49.29                                   
REMARK 500  7 GLN A  34       92.28   -175.88                                   
REMARK 500  7 ASN A  35     -166.27    -60.38                                   
REMARK 500  7 PHE A  37       16.98   -157.84                                   
REMARK 500  7 ALA A  41       -7.61    -56.32                                   
REMARK 500  7 VAL A  44      -32.98   -130.96                                   
REMARK 500  7 MET A  45       99.25    -31.36                                   
REMARK 500  7 LYS A  46       91.40    -26.79                                   
REMARK 500  7 ARG A  55      -39.85    -39.42                                   
REMARK 500  7 ALA A  61       69.95   -116.01                                   
REMARK 500  7 LEU A  65       76.59    -62.40                                   
REMARK 500  7 LYS A  66      173.37    -53.73                                   
REMARK 500  7 ARG A  79      -65.63    -28.88                                   
REMARK 500  7 PHE A  82       78.39   -118.89                                   
REMARK 500  7 GLN A  93       56.02     71.86                                   
REMARK 500  7 ASP A  95       99.50    -49.82                                   
REMARK 500  7 GLU A  99     -145.80    -76.87                                   
REMARK 500  7 ASP A 100     -145.68   -134.21                                   
REMARK 500  7 ASN A 101       34.61    -90.34                                   
REMARK 500  7 GLU A 102      -46.89   -161.30                                   
REMARK 500  7 HIS A 115       75.26    -61.63                                   
REMARK 500  7 LEU A 116      -84.27    -47.70                                   
REMARK 500  7 ARG A 117      -31.50    -38.80                                   
REMARK 500  7 HIS A 125      -60.11     71.79                                   
REMARK 500  7 SER A 128      163.50     52.38                                   
REMARK 500  7 VAL A 130      -47.57    -27.25                                   
REMARK 500  7 HIS A 132       64.77    -66.77                                   
REMARK 500  7 ASN A 134     -161.17    -54.89                                   
REMARK 500  7 ASP A 138       89.28    -65.49                                   
REMARK 500  7 THR A 139     -172.93    -57.48                                   
REMARK 500  7 ARG A 149       97.63    -62.03                                   
REMARK 500  7 ASN A 159       36.23    -84.72                                   
REMARK 500  7 THR A 165      -53.44   -133.28                                   
REMARK 500  8 PRO A   4     -158.89    -83.61                                   
REMARK 500  8 TRP A   5      133.40    -36.27                                   
REMARK 500  8 ASN A   7      -81.47   -150.92                                   
REMARK 500  8 LEU A   9      -72.55    -63.91                                   
REMARK 500  8 SER A  11      -78.17    -71.71                                   
REMARK 500  8 ASN A  27      -63.61    -91.35                                   
REMARK 500  8 ASN A  28      127.40    171.06                                   
REMARK 500  8 ASN A  30       72.35   -115.79                                   
REMARK 500  8 ALA A  33     -156.77    -62.00                                   
REMARK 500  8 GLN A  34      124.08   -170.55                                   
REMARK 500  8 MET A  45      110.85    -10.79                                   
REMARK 500  8 LYS A  46       93.05    -40.54                                   
REMARK 500  8 LEU A  65      102.95    -26.02                                   
REMARK 500  8 ASP A  67     -154.88   -117.88                                   
REMARK 500  8 ARG A  79      -61.21    -27.53                                   
REMARK 500  8 LEU A  89      -72.57    -55.64                                   
REMARK 500  8 PHE A  92       33.22    -92.31                                   
REMARK 500  8 ALA A  94      -71.60    -75.18                                   
REMARK 500  8 ASP A  95       88.48    158.43                                   
REMARK 500  8 GLU A  99     -155.82    -83.76                                   
REMARK 500  8 ASP A 100     -145.27   -113.34                                   
REMARK 500  8 GLU A 102      -40.38   -154.69                                   
REMARK 500  8 HIS A 115       74.11    -60.97                                   
REMARK 500  8 LEU A 116      -85.39    -44.36                                   
REMARK 500  8 ARG A 117      -31.31    -38.31                                   
REMARK 500  8 HIS A 125      -62.06     68.57                                   
REMARK 500  8 THR A 126      -86.93    -85.59                                   
REMARK 500  8 ALA A 127       70.47     63.50                                   
REMARK 500  8 VAL A 130       63.68    -67.05                                   
REMARK 500  8 HIS A 132       88.59    -43.76                                   
REMARK 500  8 ASN A 134     -152.29    -59.07                                   
REMARK 500  8 ASP A 138       86.34    -65.32                                   
REMARK 500  8 THR A 139     -177.96    -54.39                                   
REMARK 500  8 ALA A 140       -8.81    -57.64                                   
REMARK 500  8 LEU A 143      -63.25    -92.17                                   
REMARK 500  8 ARG A 149       72.93    -63.42                                   
REMARK 500  8 ASN A 159       39.72    -84.60                                   
REMARK 500  8 THR A 165     -178.40    -68.44                                   
REMARK 500  8 ASN A 166      170.87     55.98                                   
REMARK 500  9 ASN A   7      -73.99     59.28                                   
REMARK 500  9 SER A  11      -76.42    -49.16                                   
REMARK 500  9 ASP A  17      102.28    -44.34                                   
REMARK 500  9 ASN A  28      127.74   -177.29                                   
REMARK 500  9 VAL A  31      -27.27    -39.67                                   
REMARK 500  9 ALA A  33     -175.21    -48.62                                   
REMARK 500  9 MET A  45      114.52      0.28                                   
REMARK 500  9 LYS A  46       94.46    -44.31                                   
REMARK 500  9 LEU A  65       88.13    -49.21                                   
REMARK 500  9 ASP A  67     -152.47   -127.54                                   
REMARK 500  9 ASP A  76      -33.16    -37.36                                   
REMARK 500  9 ASP A  84      -19.92    -48.75                                   
REMARK 500  9 PHE A  92       34.57    -95.50                                   
REMARK 500  9 ASP A  95       98.26    -37.03                                   
REMARK 500  9 GLU A  99     -148.32    -75.98                                   
REMARK 500  9 ASP A 100     -146.41   -137.41                                   
REMARK 500  9 GLU A 102       -4.47   -150.28                                   
REMARK 500  9 HIS A 115       71.32    -64.07                                   
REMARK 500  9 LEU A 116      -73.59    -54.21                                   
REMARK 500  9 VAL A 118      -74.70    -72.18                                   
REMARK 500  9 HIS A 125      -48.31     74.28                                   
REMARK 500  9 SER A 128      171.02     50.23                                   
REMARK 500  9 VAL A 130       78.24    -50.76                                   
REMARK 500  9 HIS A 132       76.85    -60.45                                   
REMARK 500  9 ASN A 134     -155.93    -57.25                                   
REMARK 500  9 ASP A 138       83.57    -67.26                                   
REMARK 500  9 THR A 139     -174.28    -55.81                                   
REMARK 500  9 LEU A 143      -67.99    -90.06                                   
REMARK 500  9 ARG A 149      100.45    -33.43                                   
REMARK 500  9 ASN A 159       41.01    -82.98                                   
REMARK 500  9 ALA A 161      -39.53    176.88                                   
REMARK 500  9 THR A 165     -150.59     45.39                                   
REMARK 500  9 LEU A 167      179.06     52.07                                   
REMARK 500 10 GLU A   3       76.93     39.64                                   
REMARK 500 10 TRP A   5      123.75     59.79                                   
REMARK 500 10 ASN A   7      -65.41   -148.81                                   
REMARK 500 10 GLN A  20      -71.29    -55.46                                   
REMARK 500 10 ASN A  28      141.47   -177.79                                   
REMARK 500 10 ALA A  33     -170.95    -53.22                                   
REMARK 500 10 ASN A  35     -161.95    -75.28                                   
REMARK 500 10 MET A  45      117.53    -10.59                                   
REMARK 500 10 LYS A  46       92.90    -50.18                                   
REMARK 500 10 ASN A  62      118.90    -38.83                                   
REMARK 500 10 LEU A  65       91.53    -46.75                                   
REMARK 500 10 PHE A  92       33.14    -94.08                                   
REMARK 500 10 ASP A  95      100.95    -37.03                                   
REMARK 500 10 GLU A  99     -143.45    -95.01                                   
REMARK 500 10 ASP A 100     -159.03   -120.35                                   
REMARK 500 10 GLU A 102      -49.39   -150.54                                   
REMARK 500 10 PRO A 106      -17.84    -49.83                                   
REMARK 500 10 LEU A 109      -75.09    -50.06                                   
REMARK 500 10 HIS A 115       76.94    -59.14                                   
REMARK 500 10 LEU A 116      -82.45    -49.01                                   
REMARK 500 10 ARG A 117      -29.66    -39.61                                   
REMARK 500 10 HIS A 125      -65.11     65.52                                   
REMARK 500 10 THR A 126     -157.35    -81.19                                   
REMARK 500 10 ALA A 127       48.19    171.32                                   
REMARK 500 10 SER A 128      -67.97   -109.54                                   
REMARK 500 10 ASN A 129       66.88    -67.51                                   
REMARK 500 10 HIS A 132      158.01    -41.68                                   
REMARK 500 10 ASN A 134     -114.95    -49.04                                   
REMARK 500 10 ASP A 138       96.53    -59.09                                   
REMARK 500 10 THR A 139      177.41    -59.94                                   
REMARK 500 10 ALA A 140       -7.11    -57.90                                   
REMARK 500 10 LEU A 143      -61.54    -91.47                                   
REMARK 500 10 ASN A 159       42.60    -84.96                                   
REMARK 500 10 ALA A 161       14.84   -142.12                                   
REMARK 500 10 ASN A 166      -52.99    173.15                                   
REMARK 500 11 ALA A   2      171.74     63.75                                   
REMARK 500 11 GLU A   3       67.09     34.76                                   
REMARK 500 11 TRP A   5       96.79     54.22                                   
REMARK 500 11 LEU A   9      -77.77    -43.22                                   
REMARK 500 11 SER A  11      -79.22    -58.54                                   
REMARK 500 11 ASP A  17      106.42    -48.63                                   
REMARK 500 11 THR A  22      -76.47    -47.56                                   
REMARK 500 11 ASN A  28      149.39    177.84                                   
REMARK 500 11 VAL A  31      -27.31    -39.32                                   
REMARK 500 11 ALA A  33     -163.38    -55.78                                   
REMARK 500 11 GLN A  34      111.52   -177.40                                   
REMARK 500 11 MET A  45      113.84    -10.76                                   
REMARK 500 11 LYS A  46       94.13    -43.81                                   
REMARK 500 11 LEU A  65       94.92    -44.71                                   
REMARK 500 11 HIS A  75      -71.23    -57.42                                   
REMARK 500 11 GLN A  93       68.13     65.45                                   
REMARK 500 11 ASP A  95       86.96    -50.13                                   
REMARK 500 11 GLU A  99     -149.26    -97.53                                   
REMARK 500 11 ASP A 100     -151.75   -114.93                                   
REMARK 500 11 GLU A 102      -45.80   -144.42                                   
REMARK 500 11 HIS A 115       70.61    -64.30                                   
REMARK 500 11 LEU A 116      -81.36    -45.90                                   
REMARK 500 11 ARG A 117      -29.83    -39.59                                   
REMARK 500 11 HIS A 125      -63.63     70.27                                   
REMARK 500 11 SER A 128      139.46     61.06                                   
REMARK 500 11 ASN A 129       55.97    -67.83                                   
REMARK 500 11 VAL A 130       63.70    -63.10                                   
REMARK 500 11 HIS A 132      149.63    -25.42                                   
REMARK 500 11 ASN A 134     -119.77    -53.33                                   
REMARK 500 11 ASP A 138       93.99    -60.32                                   
REMARK 500 11 THR A 139     -169.58    -58.70                                   
REMARK 500 11 ARG A 149      109.43    -38.15                                   
REMARK 500 11 ASN A 159       43.55    -81.67                                   
REMARK 500 11 ALA A 161      -31.83   -139.33                                   
REMARK 500 11 ALA A 164       73.53     58.72                                   
REMARK 500 11 ASN A 166       71.18    -67.76                                   
REMARK 500 12 GLU A   3       79.87     37.68                                   
REMARK 500 12 TRP A   5      125.21     60.34                                   
REMARK 500 12 ASN A  27      -60.45   -101.04                                   
REMARK 500 12 ASN A  28      136.82    177.60                                   
REMARK 500 12 ALA A  33     -162.62    -53.43                                   
REMARK 500 12 GLN A  34      120.10   -170.56                                   
REMARK 500 12 ASN A  35     -161.95    -71.05                                   
REMARK 500 12 MET A  45      114.89      7.62                                   
REMARK 500 12 LYS A  46       77.74    -66.61                                   
REMARK 500 12 ASN A  62      106.15    -51.47                                   
REMARK 500 12 LEU A  65       95.27    -36.97                                   
REMARK 500 12 ASP A  76      -34.57    -38.90                                   
REMARK 500 12 PHE A  92       31.73    -90.10                                   
REMARK 500 12 GLN A  93       68.93     36.52                                   
REMARK 500 12 ALA A  94      -89.41    -86.74                                   
REMARK 500 12 ASP A  95       92.25    174.72                                   
REMARK 500 12 GLU A  99     -158.15    -88.71                                   
REMARK 500 12 ASP A 100     -139.94   -109.75                                   
REMARK 500 12 GLU A 102      -39.54   -149.46                                   
REMARK 500 12 HIS A 115       66.40    -64.46                                   
REMARK 500 12 LEU A 116      -77.75    -47.90                                   
REMARK 500 12 ARG A 117      -34.40    -39.16                                   
REMARK 500 12 THR A 126     -156.62   -117.11                                   
REMARK 500 12 SER A 128      113.41     50.33                                   
REMARK 500 12 ASN A 129       58.98    -67.83                                   
REMARK 500 12 HIS A 132       81.00    -60.69                                   
REMARK 500 12 ASN A 134     -156.34    -57.84                                   
REMARK 500 12 ASP A 138       86.06    -65.77                                   
REMARK 500 12 THR A 139     -177.29    -54.11                                   
REMARK 500 12 LEU A 143      -68.54    -91.14                                   
REMARK 500 12 ARG A 149       92.96    -60.06                                   
REMARK 500 12 ASN A 159       39.48    -85.78                                   
REMARK 500 12 ALA A 161      -34.36   -169.68                                   
REMARK 500 12 ALA A 164      -34.95   -133.49                                   
REMARK 500 13 ALA A   2       71.76     43.20                                   
REMARK 500 13 PRO A   4     -158.99    -79.20                                   
REMARK 500 13 TRP A   5     -147.87     69.52                                   
REMARK 500 13 LEU A   9      -74.08    -43.48                                   
REMARK 500 13 SER A  11      -76.39    -79.01                                   
REMARK 500 13 ASP A  17       88.77    -69.06                                   
REMARK 500 13 ASN A  27      -78.88    -85.11                                   
REMARK 500 13 ASN A  28      137.11    158.68                                   
REMARK 500 13 VAL A  29      110.58   -172.59                                   
REMARK 500 13 ASN A  30       87.82    -44.10                                   
REMARK 500 13 ALA A  33     -161.72    -50.67                                   
REMARK 500 13 GLN A  34      110.10   -169.49                                   
REMARK 500 13 ASN A  35     -164.22    -78.34                                   
REMARK 500 13 MET A  45      116.84    -28.26                                   
REMARK 500 13 LYS A  46       95.52    -42.83                                   
REMARK 500 13 LEU A  65      109.94    -31.38                                   
REMARK 500 13 ASP A  67     -152.63   -118.31                                   
REMARK 500 13 ARG A  79      -52.67    -28.89                                   
REMARK 500 13 LEU A  89      -70.74    -55.38                                   
REMARK 500 13 PHE A  92       31.01    -91.86                                   
REMARK 500 13 GLN A  93       62.98     62.44                                   
REMARK 500 13 ALA A  94      -93.03    -88.99                                   
REMARK 500 13 ASP A  95       92.49    163.36                                   
REMARK 500 13 GLU A  99     -151.30    -82.54                                   
REMARK 500 13 ASP A 100     -146.17   -118.36                                   
REMARK 500 13 GLU A 102      -38.39   -154.87                                   
REMARK 500 13 HIS A 115       73.02    -61.32                                   
REMARK 500 13 LEU A 116      -81.39    -44.46                                   
REMARK 500 13 ARG A 117      -34.26    -38.57                                   
REMARK 500 13 HIS A 125      -57.00     66.53                                   
REMARK 500 13 THR A 126     -160.81    -78.30                                   
REMARK 500 13 SER A 128      115.32     51.06                                   
REMARK 500 13 VAL A 130      -90.38    -45.29                                   
REMARK 500 13 HIS A 132       82.31    -61.23                                   
REMARK 500 13 ASN A 134     -154.50    -60.41                                   
REMARK 500 13 ASP A 138       88.17    -63.27                                   
REMARK 500 13 THR A 139     -176.78    -54.97                                   
REMARK 500 13 LEU A 143      -62.73    -91.81                                   
REMARK 500 13 ARG A 149       86.91    -56.84                                   
REMARK 500 13 ASN A 159       40.09    -85.72                                   
REMARK 500 13 ALA A 161      -40.36    171.07                                   
REMARK 500 14 GLU A   3       72.50     38.48                                   
REMARK 500 14 TRP A   5      120.09     57.72                                   
REMARK 500 14 ASN A   7      -75.54   -114.14                                   
REMARK 500 14 SER A  11      -70.78    -56.28                                   
REMARK 500 14 ASN A  28      149.85    177.90                                   
REMARK 500 14 VAL A  31      -26.64    -39.19                                   
REMARK 500 14 ALA A  33      179.21    -49.22                                   
REMARK 500 14 GLN A  34      124.64   -174.10                                   
REMARK 500 14 MET A  45      124.27     -5.37                                   
REMARK 500 14 LYS A  46      -26.39    -39.26                                   
REMARK 500 14 LEU A  47      -43.48     70.85                                   
REMARK 500 14 ILE A  52      -71.41    -39.13                                   
REMARK 500 14 LEU A  65       91.70    -46.31                                   
REMARK 500 14 ASP A  67     -148.12   -128.15                                   
REMARK 500 14 ASP A  76      -37.49    -37.83                                   
REMARK 500 14 GLN A  93       79.71     58.04                                   
REMARK 500 14 VAL A  96      -18.81    -49.67                                   
REMARK 500 14 GLU A  99     -137.16   -105.53                                   
REMARK 500 14 ASP A 100     -150.60   -116.87                                   
REMARK 500 14 GLU A 102      -44.96   -150.88                                   
REMARK 500 14 HIS A 115       71.57    -62.14                                   
REMARK 500 14 LEU A 116      -83.76    -45.25                                   
REMARK 500 14 ARG A 117      -30.80    -39.41                                   
REMARK 500 14 HIS A 125      -65.27     74.57                                   
REMARK 500 14 SER A 128      164.40     52.20                                   
REMARK 500 14 VAL A 130       72.99    -56.03                                   
REMARK 500 14 HIS A 132       69.29    -63.59                                   
REMARK 500 14 ASN A 134     -153.48    -67.35                                   
REMARK 500 14 ASP A 138       86.45    -64.25                                   
REMARK 500 14 THR A 139     -179.60    -53.60                                   
REMARK 500 14 ALA A 140       -9.73    -56.78                                   
REMARK 500 14 LEU A 143      -60.49    -92.90                                   
REMARK 500 14 ARG A 149      103.57    -48.07                                   
REMARK 500 14 ASN A 159       41.89    -82.79                                   
REMARK 500 14 ALA A 164      143.65    170.19                                   
REMARK 500 14 ASN A 166       48.63    179.61                                   
REMARK 500 14 LEU A 167       80.24     42.75                                   
REMARK 500 15 ALA A   2      105.79     54.66                                   
REMARK 500 15 GLU A   3       62.21    176.60                                   
REMARK 500 15 TRP A   5     -156.02    -58.62                                   
REMARK 500 15 ASN A   7     -109.82    -46.09                                   
REMARK 500 15 SER A  11      -81.86    -72.54                                   
REMARK 500 15 ASP A  17       98.30    -50.19                                   
REMARK 500 15 ASN A  28      122.26    176.88                                   
REMARK 500 15 ASN A  30       88.66    -68.21                                   
REMARK 500 15 VAL A  31      -28.62    -37.33                                   
REMARK 500 15 ALA A  33     -168.83    -52.59                                   
REMARK 500 15 GLN A  34      120.37   -174.32                                   
REMARK 500 15 MET A  45      115.66    -27.48                                   
REMARK 500 15 LYS A  46       93.06    -39.84                                   
REMARK 500 15 LEU A  65       93.46    -44.22                                   
REMARK 500 15 ARG A  79      -51.60    -28.54                                   
REMARK 500 15 PHE A  92       33.55    -91.61                                   
REMARK 500 15 GLU A  99     -157.52    -82.25                                   
REMARK 500 15 ASP A 100     -145.51   -108.87                                   
REMARK 500 15 GLU A 102      -34.89   -159.71                                   
REMARK 500 15 HIS A 115       73.16    -61.15                                   
REMARK 500 15 LEU A 116      -80.40    -45.62                                   
REMARK 500 15 ARG A 117      -30.55    -39.10                                   
REMARK 500 15 VAL A 118      -70.17    -76.47                                   
REMARK 500 15 HIS A 125     -131.85   -124.52                                   
REMARK 500 15 THR A 126     -161.81     39.34                                   
REMARK 500 15 SER A 128      113.54     47.70                                   
REMARK 500 15 ASN A 129       47.92    -83.63                                   
REMARK 500 15 VAL A 130       65.03    -67.84                                   
REMARK 500 15 HIS A 132       91.50    -38.51                                   
REMARK 500 15 ASN A 134     -157.11    -58.50                                   
REMARK 500 15 ASP A 138       84.28    -67.00                                   
REMARK 500 15 THR A 139     -179.78    -52.36                                   
REMARK 500 15 ALA A 140       -5.64    -58.35                                   
REMARK 500 15 LEU A 143      -61.61    -92.57                                   
REMARK 500 15 ARG A 149       91.97    -60.93                                   
REMARK 500 15 ASN A 159       44.28    -80.26                                   
REMARK 500 15 ALA A 164      -75.12   -114.53                                   
REMARK 500 15 ASN A 166      -72.33    -92.84                                   
REMARK 500 15 LEU A 167       73.88    -63.14                                   
REMARK 500 16 GLU A   3       75.23     39.40                                   
REMARK 500 16 PRO A   4     -156.19    -80.72                                   
REMARK 500 16 TRP A   5     -148.98    -81.14                                   
REMARK 500 16 ASN A   7      -84.40    -24.17                                   
REMARK 500 16 LEU A   9      -70.08    -57.52                                   
REMARK 500 16 SER A  11      -72.62    -65.87                                   
REMARK 500 16 ASP A  17      102.18    -56.75                                   
REMARK 500 16 ASN A  28      144.87   -176.82                                   
REMARK 500 16 ALA A  33     -166.95    -53.24                                   
REMARK 500 16 GLN A  34      124.01   -171.71                                   
REMARK 500 16 MET A  45      123.76     -7.18                                   
REMARK 500 16 LYS A  46       87.12    -55.70                                   
REMARK 500 16 ILE A  52      -73.12    -43.74                                   
REMARK 500 16 LEU A  57      -39.77    -39.99                                   
REMARK 500 16 LEU A  65       95.34    -42.58                                   
REMARK 500 16 ASP A  67     -161.94   -116.47                                   
REMARK 500 16 PHE A  92       38.73    -97.28                                   
REMARK 500 16 ASP A  95       99.03    -52.31                                   
REMARK 500 16 GLU A  99     -144.54    -75.58                                   
REMARK 500 16 ASP A 100     -143.62   -133.77                                   
REMARK 500 16 GLU A 102      -44.75   -154.10                                   
REMARK 500 16 LEU A 109      -72.46    -61.67                                   
REMARK 500 16 HIS A 115       68.41    -64.94                                   
REMARK 500 16 LEU A 116      -81.64    -45.54                                   
REMARK 500 16 ARG A 117      -32.25    -37.82                                   
REMARK 500 16 HIS A 125     -135.49   -138.22                                   
REMARK 500 16 THR A 126     -162.29     38.73                                   
REMARK 500 16 SER A 128      100.70     34.67                                   
REMARK 500 16 ASN A 129       98.68    -59.83                                   
REMARK 500 16 HIS A 132       72.45    -60.70                                   
REMARK 500 16 ASN A 134     -151.41    -65.92                                   
REMARK 500 16 ASP A 138       88.93    -65.69                                   
REMARK 500 16 THR A 139     -176.46    -54.90                                   
REMARK 500 16 LEU A 143      -66.66    -93.03                                   
REMARK 500 16 ARG A 149       78.79    -67.01                                   
REMARK 500 16 ASN A 159       46.01    -80.25                                   
REMARK 500 16 ALA A 161      -35.84   -170.95                                   
REMARK 500 16 ALA A 164      109.72    -45.82                                   
REMARK 500 16 THR A 165     -163.04   -113.58                                   
REMARK 500 16 ASN A 166      -81.21   -175.06                                   
REMARK 500 17 TRP A   5       81.33     65.90                                   
REMARK 500 17 ASN A   7      -45.95   -133.75                                   
REMARK 500 17 LEU A   9      -81.76    -58.63                                   
REMARK 500 17 ALA A  10      -36.37    -39.68                                   
REMARK 500 17 SER A  11      -88.26    -55.65                                   
REMARK 500 17 ASP A  17      107.74    -47.50                                   
REMARK 500 17 THR A  22      -71.39    -54.01                                   
REMARK 500 17 ASN A  28      143.97   -179.62                                   
REMARK 500 17 VAL A  31      -29.27    -35.67                                   
REMARK 500 17 ALA A  33     -179.29    -53.91                                   
REMARK 500 17 GLN A  34      110.85   -173.46                                   
REMARK 500 17 ASN A  35     -168.62    -66.11                                   
REMARK 500 17 MET A  45      112.73     -2.93                                   
REMARK 500 17 LYS A  46       93.42    -40.89                                   
REMARK 500 17 ASN A  62      107.94    -47.39                                   
REMARK 500 17 LEU A  65       86.01    -55.72                                   
REMARK 500 17 ASP A  67     -153.93   -116.60                                   
REMARK 500 17 GLN A  93       76.77     64.58                                   
REMARK 500 17 ASP A  95       91.20    -46.08                                   
REMARK 500 17 GLU A  99     -143.38    -96.78                                   
REMARK 500 17 ASP A 100     -154.51   -121.17                                   
REMARK 500 17 ASN A 101       30.79    -90.82                                   
REMARK 500 17 GLU A 102      -47.58   -147.83                                   
REMARK 500 17 LEU A 109      -70.27    -43.03                                   
REMARK 500 17 HIS A 115       69.22    -65.27                                   
REMARK 500 17 LEU A 116      -81.28    -47.59                                   
REMARK 500 17 ARG A 117      -31.21    -38.84                                   
REMARK 500 17 HIS A 125      -63.17     65.53                                   
REMARK 500 17 SER A 128      139.85     59.06                                   
REMARK 500 17 VAL A 130       64.75    -63.93                                   
REMARK 500 17 HIS A 132      152.38    -31.12                                   
REMARK 500 17 ASN A 134     -118.07    -51.86                                   
REMARK 500 17 ASP A 138       98.97    -57.00                                   
REMARK 500 17 THR A 139     -174.48    -63.91                                   
REMARK 500 17 LEU A 143      -68.04    -92.98                                   
REMARK 500 17 ARG A 149       91.31    -50.50                                   
REMARK 500 17 ASN A 159       48.88    -78.94                                   
REMARK 500 17 ALA A 161      -35.42   -176.82                                   
REMARK 500 17 ALA A 164       80.60    -69.30                                   
REMARK 500 17 THR A 165     -142.18     43.21                                   
REMARK 500 18 ALA A   2       38.61    176.70                                   
REMARK 500 18 TRP A   5      125.26     67.81                                   
REMARK 500 18 SER A  11      -70.51    -52.46                                   
REMARK 500 18 THR A  22      -72.31    -70.63                                   
REMARK 500 18 ASN A  28      149.56    172.67                                   
REMARK 500 18 ALA A  33     -158.44    -54.52                                   
REMARK 500 18 MET A  45      117.53    -24.51                                   
REMARK 500 18 LYS A  46       93.36    -45.88                                   
REMARK 500 18 ASN A  62      107.73    -47.90                                   
REMARK 500 18 LEU A  65       96.45    -42.65                                   
REMARK 500 18 ASP A  67     -159.23   -128.59                                   
REMARK 500 18 HIS A  75      -70.78    -52.00                                   
REMARK 500 18 ARG A  79      -59.02    -28.69                                   
REMARK 500 18 GLN A  93       56.61     72.02                                   
REMARK 500 18 ASP A  95      107.65    -44.68                                   
REMARK 500 18 GLU A  99     -152.95    -76.81                                   
REMARK 500 18 ASP A 100     -147.65   -115.62                                   
REMARK 500 18 GLU A 102      -45.27   -152.50                                   
REMARK 500 18 HIS A 115       72.04    -62.64                                   
REMARK 500 18 LEU A 116      -81.39    -44.42                                   
REMARK 500 18 ARG A 117      -36.63    -38.33                                   
REMARK 500 18 HIS A 125      -62.03     67.01                                   
REMARK 500 18 SER A 128      139.62     58.15                                   
REMARK 500 18 VAL A 130       67.28    -62.15                                   
REMARK 500 18 ASN A 134     -152.20    -59.59                                   
REMARK 500 18 ASP A 138       88.42    -65.02                                   
REMARK 500 18 THR A 139     -173.06    -56.96                                   
REMARK 500 18 LEU A 143      -69.99    -93.33                                   
REMARK 500 18 ARG A 149      109.93    -40.28                                   
REMARK 500 18 ASN A 159       40.67    -82.77                                   
REMARK 500 18 ALA A 161      -33.83   -146.62                                   
REMARK 500 18 ALA A 164      174.69    -53.54                                   
REMARK 500 18 THR A 165       36.40   -143.77                                   
REMARK 500 19 ALA A   2     -167.85   -113.15                                   
REMARK 500 19 GLU A   3       95.46    -37.22                                   
REMARK 500 19 TRP A   5     -141.70   -176.04                                   
REMARK 500 19 LEU A   9      -73.64    -67.21                                   
REMARK 500 19 SER A  11      -80.87    -51.87                                   
REMARK 500 19 ASP A  17       83.69    -60.63                                   
REMARK 500 19 ASN A  27      -75.68    -87.01                                   
REMARK 500 19 ASN A  28      134.20    161.90                                   
REMARK 500 19 VAL A  29      104.71   -173.52                                   
REMARK 500 19 ASN A  30       91.56    -36.50                                   
REMARK 500 19 ALA A  33     -161.14    -52.43                                   
REMARK 500 19 GLN A  34      113.08   -173.41                                   
REMARK 500 19 MET A  45      125.81    -15.07                                   
REMARK 500 19 LEU A  47      -31.49     77.10                                   
REMARK 500 19 ARG A  55      -36.45    -37.96                                   
REMARK 500 19 LEU A  57      -76.44    -58.68                                   
REMARK 500 19 LEU A  58      -19.55    -46.49                                   
REMARK 500 19 LEU A  65       77.38    -59.84                                   
REMARK 500 19 ASP A  67     -168.61   -123.84                                   
REMARK 500 19 ARG A  79      -71.11    -30.60                                   
REMARK 500 19 PHE A  92       30.62    -91.81                                   
REMARK 500 19 ASP A  95       96.89    -37.32                                   
REMARK 500 19 GLU A  99     -132.73    -84.40                                   
REMARK 500 19 ASP A 100     -157.12   -130.02                                   
REMARK 500 19 GLU A 102      -43.58   -148.43                                   
REMARK 500 19 HIS A 115       72.04    -61.74                                   
REMARK 500 19 LEU A 116      -77.90    -47.89                                   
REMARK 500 19 ARG A 117      -30.30    -39.77                                   
REMARK 500 19 VAL A 118      -70.42    -73.66                                   
REMARK 500 19 HIS A 125      -61.90   -151.11                                   
REMARK 500 19 THR A 126     -158.12    -63.76                                   
REMARK 500 19 SER A 128      159.13     54.37                                   
REMARK 500 19 VAL A 130       65.83    -64.72                                   
REMARK 500 19 HIS A 132       73.21    -62.23                                   
REMARK 500 19 ASN A 134     -160.79    -57.43                                   
REMARK 500 19 ASP A 138       89.57    -62.93                                   
REMARK 500 19 THR A 139     -177.04    -56.57                                   
REMARK 500 19 LEU A 143      -62.49    -93.15                                   
REMARK 500 19 ARG A 149       75.50    -60.50                                   
REMARK 500 19 ASN A 159       42.11    -81.55                                   
REMARK 500 19 ALA A 164       34.90   -159.27                                   
REMARK 500 19 THR A 165      138.50     65.84                                   
REMARK 500 20 TRP A   5       63.64    -63.42                                   
REMARK 500 20 ASN A   7      -71.53    -86.24                                   
REMARK 500 20 LEU A   9      -73.15    -68.42                                   
REMARK 500 20 SER A  11      -90.98    -66.60                                   
REMARK 500 20 ASP A  17      107.20    -54.11                                   
REMARK 500 20 THR A  22      -73.32    -52.82                                   
REMARK 500 20 ASN A  28      125.75    179.68                                   
REMARK 500 20 VAL A  31      -28.80    -36.55                                   
REMARK 500 20 ALA A  33      172.45    -45.40                                   
REMARK 500 20 GLN A  34      122.37   -172.34                                   
REMARK 500 20 MET A  45      110.35     -4.80                                   
REMARK 500 20 LYS A  46       93.69    -41.03                                   
REMARK 500 20 LEU A  65       90.05    -27.15                                   
REMARK 500 20 ASP A  67     -149.90   -107.68                                   
REMARK 500 20 PHE A  92       33.14    -91.18                                   
REMARK 500 20 GLN A  93       70.59     35.08                                   
REMARK 500 20 ALA A  94      -93.24    -85.94                                   
REMARK 500 20 ASP A  95       92.81    171.43                                   
REMARK 500 20 GLU A  99     -137.90   -104.46                                   
REMARK 500 20 ASP A 100     -151.43   -128.08                                   
REMARK 500 20 ASN A 101       36.57    -90.61                                   
REMARK 500 20 GLU A 102      -51.36   -151.38                                   
REMARK 500 20 HIS A 115       70.89    -62.30                                   
REMARK 500 20 LEU A 116      -79.22    -46.50                                   
REMARK 500 20 HIS A 125      -61.51     66.23                                   
REMARK 500 20 THR A 126     -169.18    -72.95                                   
REMARK 500 20 SER A 128      122.65     55.49                                   
REMARK 500 20 VAL A 130       63.00    -64.92                                   
REMARK 500 20 HIS A 132       76.24    -64.00                                   
REMARK 500 20 ASN A 134     -149.39    -58.70                                   
REMARK 500 20 ASP A 138       88.73    -64.23                                   
REMARK 500 20 THR A 139     -173.04    -57.23                                   
REMARK 500 20 ARG A 149       94.86    -50.00                                   
REMARK 500 20 ASN A 159       44.57    -81.65                                   
REMARK 500 20 ALA A 161      -35.00   -169.44                                   
REMARK 500 20 ALA A 164     -138.09    -73.91                                   
REMARK 500 21 GLU A   3       80.37   -164.25                                   
REMARK 500 21 LEU A   9      -82.45    -40.87                                   
REMARK 500 21 SER A  11      -77.19    -50.82                                   
REMARK 500 21 GLN A  20      -70.30    -47.75                                   
REMARK 500 21 ASN A  28      130.41    174.08                                   
REMARK 500 21 VAL A  31      -27.32    -38.43                                   
REMARK 500 21 ALA A  33     -154.54    -58.51                                   
REMARK 500 21 GLN A  34      117.03   -170.27                                   
REMARK 500 21 MET A  45       28.05     26.78                                   
REMARK 500 21 LYS A  46      -74.54     54.72                                   
REMARK 500 21 LEU A  47      -15.60    103.40                                   
REMARK 500 21 LEU A  65       91.62    -48.61                                   
REMARK 500 21 ASP A  67     -164.68   -120.93                                   
REMARK 500 21 ASP A  76      -37.50    -38.91                                   
REMARK 500 21 PHE A  92       33.80    -93.97                                   
REMARK 500 21 ASP A  95      100.04    -39.41                                   
REMARK 500 21 GLU A  99     -147.12    -77.49                                   
REMARK 500 21 ASP A 100     -142.37   -134.43                                   
REMARK 500 21 GLU A 102      -48.82   -144.17                                   
REMARK 500 21 HIS A 115       69.69    -64.49                                   
REMARK 500 21 LEU A 116      -80.81    -50.83                                   
REMARK 500 21 ARG A 117      -31.05    -38.97                                   
REMARK 500 21 VAL A 118      -70.47    -71.21                                   
REMARK 500 21 HIS A 125      -61.06     69.12                                   
REMARK 500 21 SER A 128      169.80     51.04                                   
REMARK 500 21 ASN A 129       42.92   -108.36                                   
REMARK 500 21 VAL A 130       77.45    -51.22                                   
REMARK 500 21 HIS A 132       73.70    -60.74                                   
REMARK 500 21 ASN A 134     -153.89    -57.96                                   
REMARK 500 21 ASP A 138       89.48    -64.27                                   
REMARK 500 21 THR A 139     -176.66    -55.65                                   
REMARK 500 21 LEU A 143      -64.67    -90.60                                   
REMARK 500 21 ARG A 149       88.50    -69.57                                   
REMARK 500 21 ASN A 159       44.39    -81.24                                   
REMARK 500 21 ALA A 164       77.20   -168.20                                   
REMARK 500 21 THR A 165       82.62    -67.76                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  1 ARG A  15         0.17    SIDE_CHAIN                              
REMARK 500  1 ARG A  39         0.10    SIDE_CHAIN                              
REMARK 500  1 ARG A  54         0.32    SIDE_CHAIN                              
REMARK 500  1 ARG A  55         0.18    SIDE_CHAIN                              
REMARK 500  1 ARG A  68         0.20    SIDE_CHAIN                              
REMARK 500  1 ARG A  79         0.31    SIDE_CHAIN                              
REMARK 500  1 ARG A 117         0.30    SIDE_CHAIN                              
REMARK 500  1 ARG A 133         0.26    SIDE_CHAIN                              
REMARK 500  1 ARG A 145         0.18    SIDE_CHAIN                              
REMARK 500  1 ARG A 149         0.29    SIDE_CHAIN                              
REMARK 500  2 ARG A  15         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A  39         0.28    SIDE_CHAIN                              
REMARK 500  2 ARG A  54         0.29    SIDE_CHAIN                              
REMARK 500  2 ARG A  55         0.26    SIDE_CHAIN                              
REMARK 500  2 ARG A  59         0.27    SIDE_CHAIN                              
REMARK 500  2 ARG A  68         0.31    SIDE_CHAIN                              
REMARK 500  2 ARG A  79         0.18    SIDE_CHAIN                              
REMARK 500  2 ARG A 117         0.22    SIDE_CHAIN                              
REMARK 500  2 ARG A 133         0.25    SIDE_CHAIN                              
REMARK 500  2 ARG A 145         0.26    SIDE_CHAIN                              
REMARK 500  2 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A  39         0.12    SIDE_CHAIN                              
REMARK 500  3 ARG A  54         0.28    SIDE_CHAIN                              
REMARK 500  3 ARG A  55         0.11    SIDE_CHAIN                              
REMARK 500  3 ARG A  59         0.26    SIDE_CHAIN                              
REMARK 500  3 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500  3 ARG A  79         0.24    SIDE_CHAIN                              
REMARK 500  3 ARG A 117         0.14    SIDE_CHAIN                              
REMARK 500  3 ARG A 133         0.21    SIDE_CHAIN                              
REMARK 500  3 ARG A 145         0.19    SIDE_CHAIN                              
REMARK 500  3 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500  4 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500  4 ARG A  39         0.16    SIDE_CHAIN                              
REMARK 500  4 ARG A  54         0.24    SIDE_CHAIN                              
REMARK 500  4 ARG A  55         0.20    SIDE_CHAIN                              
REMARK 500  4 ARG A  59         0.20    SIDE_CHAIN                              
REMARK 500  4 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500  4 ARG A  79         0.30    SIDE_CHAIN                              
REMARK 500  4 ARG A 117         0.32    SIDE_CHAIN                              
REMARK 500  4 ARG A 133         0.23    SIDE_CHAIN                              
REMARK 500  4 ARG A 145         0.19    SIDE_CHAIN                              
REMARK 500  4 ARG A 149         0.27    SIDE_CHAIN                              
REMARK 500  5 ARG A  15         0.32    SIDE_CHAIN                              
REMARK 500  5 ARG A  39         0.16    SIDE_CHAIN                              
REMARK 500  5 ARG A  54         0.31    SIDE_CHAIN                              
REMARK 500  5 ARG A  55         0.24    SIDE_CHAIN                              
REMARK 500  5 ARG A  59         0.11    SIDE_CHAIN                              
REMARK 500  5 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500  5 ARG A  79         0.23    SIDE_CHAIN                              
REMARK 500  5 ARG A 117         0.26    SIDE_CHAIN                              
REMARK 500  5 ARG A 145         0.16    SIDE_CHAIN                              
REMARK 500  5 ARG A 149         0.08    SIDE_CHAIN                              
REMARK 500  6 ARG A  15         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG A  39         0.26    SIDE_CHAIN                              
REMARK 500  6 ARG A  54         0.09    SIDE_CHAIN                              
REMARK 500  6 ARG A  55         0.18    SIDE_CHAIN                              
REMARK 500  6 ARG A  59         0.29    SIDE_CHAIN                              
REMARK 500  6 ARG A  68         0.22    SIDE_CHAIN                              
REMARK 500  6 ARG A  79         0.21    SIDE_CHAIN                              
REMARK 500  6 ARG A 133         0.22    SIDE_CHAIN                              
REMARK 500  6 ARG A 145         0.30    SIDE_CHAIN                              
REMARK 500  6 ARG A 149         0.25    SIDE_CHAIN                              
REMARK 500  7 ARG A  15         0.30    SIDE_CHAIN                              
REMARK 500  7 ARG A  39         0.20    SIDE_CHAIN                              
REMARK 500  7 ARG A  54         0.32    SIDE_CHAIN                              
REMARK 500  7 ARG A  55         0.27    SIDE_CHAIN                              
REMARK 500  7 ARG A  59         0.22    SIDE_CHAIN                              
REMARK 500  7 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500  7 ARG A  79         0.32    SIDE_CHAIN                              
REMARK 500  7 ARG A 117         0.22    SIDE_CHAIN                              
REMARK 500  7 ARG A 133         0.11    SIDE_CHAIN                              
REMARK 500  7 ARG A 145         0.29    SIDE_CHAIN                              
REMARK 500  7 ARG A 149         0.30    SIDE_CHAIN                              
REMARK 500  8 ARG A  15         0.14    SIDE_CHAIN                              
REMARK 500  8 ARG A  39         0.27    SIDE_CHAIN                              
REMARK 500  8 ARG A  54         0.32    SIDE_CHAIN                              
REMARK 500  8 ARG A  55         0.23    SIDE_CHAIN                              
REMARK 500  8 ARG A  59         0.21    SIDE_CHAIN                              
REMARK 500  8 ARG A  68         0.28    SIDE_CHAIN                              
REMARK 500  8 ARG A  79         0.28    SIDE_CHAIN                              
REMARK 500  8 ARG A 117         0.23    SIDE_CHAIN                              
REMARK 500  8 ARG A 149         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A  15         0.21    SIDE_CHAIN                              
REMARK 500  9 ARG A  39         0.20    SIDE_CHAIN                              
REMARK 500  9 ARG A  54         0.18    SIDE_CHAIN                              
REMARK 500  9 ARG A  55         0.21    SIDE_CHAIN                              
REMARK 500  9 ARG A  59         0.26    SIDE_CHAIN                              
REMARK 500  9 ARG A  68         0.25    SIDE_CHAIN                              
REMARK 500  9 ARG A  79         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A 117         0.31    SIDE_CHAIN                              
REMARK 500  9 ARG A 133         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A 149         0.29    SIDE_CHAIN                              
REMARK 500 10 ARG A  15         0.32    SIDE_CHAIN                              
REMARK 500 10 ARG A  39         0.18    SIDE_CHAIN                              
REMARK 500 10 ARG A  55         0.32    SIDE_CHAIN                              
REMARK 500 10 ARG A  59         0.18    SIDE_CHAIN                              
REMARK 500 10 ARG A  68         0.31    SIDE_CHAIN                              
REMARK 500 10 ARG A  79         0.23    SIDE_CHAIN                              
REMARK 500 10 ARG A 117         0.22    SIDE_CHAIN                              
REMARK 500 10 ARG A 133         0.11    SIDE_CHAIN                              
REMARK 500 10 ARG A 145         0.22    SIDE_CHAIN                              
REMARK 500 10 ARG A 149         0.30    SIDE_CHAIN                              
REMARK 500 11 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500 11 ARG A  39         0.09    SIDE_CHAIN                              
REMARK 500 11 ARG A  54         0.32    SIDE_CHAIN                              
REMARK 500 11 ARG A  59         0.24    SIDE_CHAIN                              
REMARK 500 11 ARG A  68         0.16    SIDE_CHAIN                              
REMARK 500 11 ARG A 117         0.29    SIDE_CHAIN                              
REMARK 500 11 ARG A 133         0.28    SIDE_CHAIN                              
REMARK 500 11 ARG A 145         0.30    SIDE_CHAIN                              
REMARK 500 11 ARG A 149         0.13    SIDE_CHAIN                              
REMARK 500 12 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500 12 ARG A  39         0.24    SIDE_CHAIN                              
REMARK 500 12 ARG A  54         0.23    SIDE_CHAIN                              
REMARK 500 12 ARG A  59         0.21    SIDE_CHAIN                              
REMARK 500 12 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500 12 ARG A  79         0.13    SIDE_CHAIN                              
REMARK 500 12 ARG A 117         0.31    SIDE_CHAIN                              
REMARK 500 12 ARG A 133         0.26    SIDE_CHAIN                              
REMARK 500 12 ARG A 145         0.31    SIDE_CHAIN                              
REMARK 500 12 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500 13 ARG A  15         0.28    SIDE_CHAIN                              
REMARK 500 13 ARG A  39         0.11    SIDE_CHAIN                              
REMARK 500 13 ARG A  54         0.14    SIDE_CHAIN                              
REMARK 500 13 ARG A  55         0.18    SIDE_CHAIN                              
REMARK 500 13 ARG A  59         0.32    SIDE_CHAIN                              
REMARK 500 13 ARG A  68         0.16    SIDE_CHAIN                              
REMARK 500 13 ARG A  79         0.31    SIDE_CHAIN                              
REMARK 500 13 ARG A 117         0.18    SIDE_CHAIN                              
REMARK 500 13 ARG A 133         0.13    SIDE_CHAIN                              
REMARK 500 13 ARG A 145         0.28    SIDE_CHAIN                              
REMARK 500 13 ARG A 149         0.32    SIDE_CHAIN                              
REMARK 500 14 ARG A  15         0.25    SIDE_CHAIN                              
REMARK 500 14 ARG A  39         0.14    SIDE_CHAIN                              
REMARK 500 14 ARG A  54         0.18    SIDE_CHAIN                              
REMARK 500 14 ARG A  55         0.16    SIDE_CHAIN                              
REMARK 500 14 ARG A  59         0.29    SIDE_CHAIN                              
REMARK 500 14 ARG A  68         0.19    SIDE_CHAIN                              
REMARK 500 14 ARG A  79         0.23    SIDE_CHAIN                              
REMARK 500 14 ARG A 133         0.23    SIDE_CHAIN                              
REMARK 500 14 ARG A 145         0.31    SIDE_CHAIN                              
REMARK 500 14 ARG A 149         0.12    SIDE_CHAIN                              
REMARK 500 15 ARG A  15         0.30    SIDE_CHAIN                              
REMARK 500 15 ARG A  39         0.21    SIDE_CHAIN                              
REMARK 500 15 ARG A  54         0.17    SIDE_CHAIN                              
REMARK 500 15 ARG A  55         0.28    SIDE_CHAIN                              
REMARK 500 15 ARG A  59         0.25    SIDE_CHAIN                              
REMARK 500 15 ARG A  68         0.22    SIDE_CHAIN                              
REMARK 500 15 ARG A  79         0.32    SIDE_CHAIN                              
REMARK 500 15 ARG A 117         0.32    SIDE_CHAIN                              
REMARK 500 15 ARG A 133         0.31    SIDE_CHAIN                              
REMARK 500 15 ARG A 145         0.23    SIDE_CHAIN                              
REMARK 500 15 ARG A 149         0.25    SIDE_CHAIN                              
REMARK 500 16 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500 16 ARG A  39         0.25    SIDE_CHAIN                              
REMARK 500 16 ARG A  54         0.14    SIDE_CHAIN                              
REMARK 500 16 ARG A  55         0.22    SIDE_CHAIN                              
REMARK 500 16 ARG A  59         0.28    SIDE_CHAIN                              
REMARK 500 16 ARG A  68         0.23    SIDE_CHAIN                              
REMARK 500 16 ARG A  79         0.19    SIDE_CHAIN                              
REMARK 500 16 ARG A 117         0.30    SIDE_CHAIN                              
REMARK 500 16 ARG A 133         0.28    SIDE_CHAIN                              
REMARK 500 16 ARG A 145         0.31    SIDE_CHAIN                              
REMARK 500 16 ARG A 149         0.32    SIDE_CHAIN                              
REMARK 500 17 ARG A  15         0.11    SIDE_CHAIN                              
REMARK 500 17 ARG A  39         0.32    SIDE_CHAIN                              
REMARK 500 17 ARG A  54         0.26    SIDE_CHAIN                              
REMARK 500 17 ARG A  55         0.30    SIDE_CHAIN                              
REMARK 500 17 ARG A  59         0.22    SIDE_CHAIN                              
REMARK 500 17 ARG A  68         0.26    SIDE_CHAIN                              
REMARK 500 17 ARG A  79         0.29    SIDE_CHAIN                              
REMARK 500 17 ARG A 117         0.31    SIDE_CHAIN                              
REMARK 500 17 ARG A 133         0.26    SIDE_CHAIN                              
REMARK 500 17 ARG A 145         0.20    SIDE_CHAIN                              
REMARK 500 17 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500 18 ARG A  15         0.30    SIDE_CHAIN                              
REMARK 500 18 ARG A  39         0.24    SIDE_CHAIN                              
REMARK 500 18 ARG A  55         0.18    SIDE_CHAIN                              
REMARK 500 18 ARG A  59         0.21    SIDE_CHAIN                              
REMARK 500 18 ARG A  68         0.26    SIDE_CHAIN                              
REMARK 500 18 ARG A  79         0.15    SIDE_CHAIN                              
REMARK 500 18 ARG A 117         0.19    SIDE_CHAIN                              
REMARK 500 18 ARG A 133         0.30    SIDE_CHAIN                              
REMARK 500 18 ARG A 145         0.29    SIDE_CHAIN                              
REMARK 500 18 ARG A 149         0.13    SIDE_CHAIN                              
REMARK 500 19 ARG A  15         0.31    SIDE_CHAIN                              
REMARK 500 19 ARG A  54         0.31    SIDE_CHAIN                              
REMARK 500 19 ARG A  55         0.32    SIDE_CHAIN                              
REMARK 500 19 ARG A  59         0.22    SIDE_CHAIN                              
REMARK 500 19 ARG A  68         0.32    SIDE_CHAIN                              
REMARK 500 19 ARG A  79         0.24    SIDE_CHAIN                              
REMARK 500 19 ARG A 117         0.32    SIDE_CHAIN                              
REMARK 500 19 ARG A 133         0.20    SIDE_CHAIN                              
REMARK 500 20 ARG A  15         0.32    SIDE_CHAIN                              
REMARK 500 20 ARG A  39         0.08    SIDE_CHAIN                              
REMARK 500 20 ARG A  54         0.25    SIDE_CHAIN                              
REMARK 500 20 ARG A  55         0.14    SIDE_CHAIN                              
REMARK 500 20 ARG A  59         0.27    SIDE_CHAIN                              
REMARK 500 20 ARG A  68         0.26    SIDE_CHAIN                              
REMARK 500 20 ARG A  79         0.21    SIDE_CHAIN                              
REMARK 500 20 ARG A 117         0.08    SIDE_CHAIN                              
REMARK 500 20 ARG A 133         0.31    SIDE_CHAIN                              
REMARK 500 20 ARG A 145         0.24    SIDE_CHAIN                              
REMARK 500 20 ARG A 149         0.29    SIDE_CHAIN                              
REMARK 500 21 ARG A  15         0.25    SIDE_CHAIN                              
REMARK 500 21 ARG A  39         0.27    SIDE_CHAIN                              
REMARK 500 21 ARG A  54         0.15    SIDE_CHAIN                              
REMARK 500 21 ARG A  55         0.14    SIDE_CHAIN                              
REMARK 500 21 ARG A  59         0.31    SIDE_CHAIN                              
REMARK 500 21 ARG A  79         0.10    SIDE_CHAIN                              
REMARK 500 21 ARG A 117         0.32    SIDE_CHAIN                              
REMARK 500 21 ARG A 133         0.23    SIDE_CHAIN                              
REMARK 500 21 ARG A 145         0.22    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  1BU9 A    1   168  UNP    P42773   CDN2C_HUMAN      1    168             
SEQRES   1 A  168  MET ALA GLU PRO TRP GLY ASN GLU LEU ALA SER ALA ALA          
SEQRES   2 A  168  ALA ARG GLY ASP LEU GLU GLN LEU THR SER LEU LEU GLN          
SEQRES   3 A  168  ASN ASN VAL ASN VAL ASN ALA GLN ASN GLY PHE GLY ARG          
SEQRES   4 A  168  THR ALA LEU GLN VAL MET LYS LEU GLY ASN PRO GLU ILE          
SEQRES   5 A  168  ALA ARG ARG LEU LEU LEU ARG GLY ALA ASN PRO ASP LEU          
SEQRES   6 A  168  LYS ASP ARG THR GLY PHE ALA VAL ILE HIS ASP ALA ALA          
SEQRES   7 A  168  ARG ALA GLY PHE LEU ASP THR LEU GLN THR LEU LEU GLU          
SEQRES   8 A  168  PHE GLN ALA ASP VAL ASN ILE GLU ASP ASN GLU GLY ASN          
SEQRES   9 A  168  LEU PRO LEU HIS LEU ALA ALA LYS GLU GLY HIS LEU ARG          
SEQRES  10 A  168  VAL VAL GLU PHE LEU VAL LYS HIS THR ALA SER ASN VAL          
SEQRES  11 A  168  GLY HIS ARG ASN HIS LYS GLY ASP THR ALA CYS ASP LEU          
SEQRES  12 A  168  ALA ARG LEU TYR GLY ARG ASN GLU VAL VAL SER LEU MET          
SEQRES  13 A  168  GLN ALA ASN GLY ALA GLY GLY ALA THR ASN LEU GLN              
HELIX    1  IA GLU A    8  ARG A   15  1                                   8    
HELIX    2  1B LEU A   18  GLN A   26  1                                   9    
HELIX    3  2A ALA A   41  VAL A   44  1                                   4    
HELIX    4  2B PRO A   50  LEU A   58  1                                   9    
HELIX    5  3A VAL A   73  ARG A   79  1                                   7    
HELIX    6  3B LEU A   83  GLU A   91  1                                   9    
HELIX    7  4A PRO A  106  LYS A  112  1                                   7    
HELIX    8  4B LEU A  116  VAL A  123  1                                   8    
HELIX    9  5A ALA A  140  TYR A  147  1                                   8    
HELIX   10  5B ASN A  150  ALA A  158  1                                   9    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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