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Database: PDB
Entry: 1NFA
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HEADER    TRANSCRIPTION REGULATION                18-JAN-97   1NFA              
TITLE     HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR,             
TITLE    2 10 STRUCTURES                                                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HUMAN TRANSCRIPTION FACTOR NFATC1;                         
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: DNA-BINDING DOMAIN, RESIDUES 416 - 591;                    
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 CELL_LINE: BL21;                                                     
SOURCE   6 CELLULAR_LOCATION: CYTOPLASM UNTIL DEPHOSPHORYLATED;                 
SOURCE   7 GENE: NFATC1;                                                        
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  10 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3) PLYSS;                          
SOURCE  11 EXPRESSION_SYSTEM_VECTOR_TYPE: BACTERIAL;                            
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PLM1;                                     
SOURCE  13 EXPRESSION_SYSTEM_GENE: NFATC1                                       
KEYWDS    NFAT, TRANSCRIPTION REGULATION, REL-HOMOLOGY FOLD,                    
KEYWDS   2 ACTIVATES CYTOKINE TRANSCRIPTION                                     
EXPDTA    SOLUTION NMR                                                          
NUMMDL    10                                                                    
AUTHOR    S.A.WOLFE,P.ZHOU,V.DOTSCH,L.CHEN,A.YOU,S.N.HO,G.R.CRABTREE,           
AUTHOR   2 G.WAGNER,G.L.VERDINE                                                 
REVDAT   2   24-FEB-09 1NFA    1       VERSN                                    
REVDAT   1   01-APR-97 1NFA    0                                                
JRNL        AUTH   S.A.WOLFE,P.ZHOU,V.DOTSCH,L.CHEN,A.YOU,S.N.HO,               
JRNL        AUTH 2 G.R.CRABTREE,G.WAGNER,G.L.VERDINE                            
JRNL        TITL   UNUSUAL REL-LIKE ARCHITECTURE IN THE DNA-BINDING             
JRNL        TITL 2 DOMAIN OF THE TRANSCRIPTION FACTOR NFATC.                    
JRNL        REF    NATURE                        V. 385   172 1997              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   8990122                                                      
JRNL        DOI    10.1038/385172A0                                             
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : DIANA                                                
REMARK   3   AUTHORS     : WUTHRICH                                             
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: CALCULATIONS WERE PERFORMED BASED ON      
REMARK   3  1087 EFFECTIVE NON-HYDROGEN-BOND CONSTRAINTS WITH 3 REDAC           
REMARK   3  CYCLES. STRUCTURES WITH TARGET FUNCTIONS BELOW 10 WERE FURTHER      
REMARK   3  REFINED BY SIMULATED ANNEALING USING X-PLOR.                        
REMARK   4                                                                      
REMARK   4 1NFA COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.                                
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 300                                
REMARK 210  PH                             : 6.5                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 3D 15N NOESY-HSQC, 2D 1H-1H        
REMARK 210                                   NOESY, 3D 13C NOESY-HSQC, HNHA     
REMARK 210  SPECTROMETER FIELD STRENGTH    : 500 MHZ, 750 MHZ                   
REMARK 210  SPECTROMETER MODEL             : DMX-500, UNITY PLUS 750            
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER, VARIAN                     
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : DIANA, XPLOR                       
REMARK 210   METHOD USED                   : DISTANCE GEOMETRY                  
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 40                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 10                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : CLOSEST BACKBONE RMSD TO THE       
REMARK 210                                   MEAN                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: THE STRUCTURE WAS DETERMINED USING TRIPLE-RESONANCE NMR      
REMARK 210  SPECTROSCOPY USING 13C, 15N-LABELED NFATC. IONIC_STRENGTH: 100      
REMARK 210  MM KCL PRESSURE: NULL SOLVENT SYSTEM: H2O                           
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 LYS A   2     -153.77   -154.44                                   
REMARK 500  1 GLN A   5       77.88    174.42                                   
REMARK 500  1 SER A   8       41.35   -155.68                                   
REMARK 500  1 SER A  10       55.10   -166.23                                   
REMARK 500  1 PRO A  12     -163.03    -77.18                                   
REMARK 500  1 GLU A  14      126.80   -172.31                                   
REMARK 500  1 LYS A  22      162.60    -43.18                                   
REMARK 500  1 SER A  23       50.02   -119.48                                   
REMARK 500  1 HIS A  25      118.60   -170.40                                   
REMARK 500  1 HIS A  28       55.93   -162.75                                   
REMARK 500  1 TYR A  29      115.03   -179.93                                   
REMARK 500  1 GLU A  30       74.23    173.42                                   
REMARK 500  1 THR A  31       32.64   -145.69                                   
REMARK 500  1 GLU A  32      -72.62   -102.72                                   
REMARK 500  1 SER A  34      -38.99   -154.75                                   
REMARK 500  1 ARG A  35       42.50   -161.57                                   
REMARK 500  1 ALA A  40     -152.94    -74.24                                   
REMARK 500  1 PRO A  46     -167.93    -79.43                                   
REMARK 500  1 LEU A  54       35.61    -99.96                                   
REMARK 500  1 ASN A  56       34.60    -87.72                                   
REMARK 500  1 ASP A  70      -55.26   -142.50                                   
REMARK 500  1 ARG A  71      -34.66   -174.66                                   
REMARK 500  1 LEU A  72       86.80    -66.34                                   
REMARK 500  1 ALA A  77      -76.29    -67.12                                   
REMARK 500  1 HIS A  82       59.38   -175.93                                   
REMARK 500  1 THR A  85     -147.39   -145.52                                   
REMARK 500  1 SER A  99      103.68     77.03                                   
REMARK 500  1 THR A 101       87.96   -159.58                                   
REMARK 500  1 ASN A 112      -67.52   -165.39                                   
REMARK 500  1 SER A 113      108.05    164.63                                   
REMARK 500  1 MET A 114       49.83   -154.67                                   
REMARK 500  1 ASP A 119       39.48   -149.50                                   
REMARK 500  1 CYS A 120       59.03   -145.05                                   
REMARK 500  1 LEU A 126       24.13   -141.77                                   
REMARK 500  1 ASN A 128       27.60   -168.66                                   
REMARK 500  1 ASP A 130       68.23    163.93                                   
REMARK 500  1 ARG A 134      -61.01   -167.06                                   
REMARK 500  1 LYS A 135      142.48    164.73                                   
REMARK 500  1 THR A 138      -49.06   -152.16                                   
REMARK 500  1 ASP A 139      -70.91    166.13                                   
REMARK 500  1 ILE A 140      -42.30   -145.22                                   
REMARK 500  1 ARG A 142       52.20   -140.95                                   
REMARK 500  1 ASN A 144      164.11    -47.11                                   
REMARK 500  1 THR A 145       51.48   -154.43                                   
REMARK 500  1 THR A 162      -79.77   -136.39                                   
REMARK 500  1 SER A 164      106.34   -163.83                                   
REMARK 500  1 ASN A 170       92.49    171.74                                   
REMARK 500  1 ILE A 172       78.74   -115.21                                   
REMARK 500  2 GLN A   5       79.32    170.47                                   
REMARK 500  2 SER A  10     -175.05     64.82                                   
REMARK 500  2 SER A  23       58.72   -154.62                                   
REMARK 500  2 HIS A  25      113.12   -163.86                                   
REMARK 500  2 GLU A  30     -148.41   -114.49                                   
REMARK 500  2 SER A  34      -90.83     61.18                                   
REMARK 500  2 VAL A  38      106.08    -54.84                                   
REMARK 500  2 SER A  41      144.69     60.87                                   
REMARK 500  2 ALA A  42      -90.53     51.45                                   
REMARK 500  2 TYR A  53      129.51    -39.56                                   
REMARK 500  2 ASP A  70      -49.49   -133.00                                   
REMARK 500  2 ARG A  71      -38.68   -175.06                                   
REMARK 500  2 LEU A  72       89.35    -55.89                                   
REMARK 500  2 LEU A  73      171.79    -51.90                                   
REMARK 500  2 HIS A  76      161.33    -42.07                                   
REMARK 500  2 ALA A  77      -74.91    -48.83                                   
REMARK 500  2 GLN A  80       23.69   -163.32                                   
REMARK 500  2 HIS A  82       75.53   -175.38                                   
REMARK 500  2 SER A  99      114.16     76.66                                   
REMARK 500  2 PRO A 110       45.47    -81.02                                   
REMARK 500  2 SER A 113      102.89    169.80                                   
REMARK 500  2 ASP A 119       50.72   -153.71                                   
REMARK 500  2 ARG A 127      -87.35     63.09                                   
REMARK 500  2 ASN A 128      107.75    -42.06                                   
REMARK 500  2 SER A 129      -39.30    175.96                                   
REMARK 500  2 ASP A 130       54.42     83.30                                   
REMARK 500  2 GLU A 132       98.29    177.02                                   
REMARK 500  2 GLU A 137      -43.47     83.00                                   
REMARK 500  2 ASP A 139     -175.10    178.94                                   
REMARK 500  2 THR A 145       53.53   -159.99                                   
REMARK 500  2 SER A 159      -84.28    -54.28                                   
REMARK 500  2 THR A 162      -89.56   -133.55                                   
REMARK 500  2 SER A 164      119.26   -163.25                                   
REMARK 500  2 ASN A 170       97.73    175.93                                   
REMARK 500  2 SER A 175       34.55    178.52                                   
REMARK 500  2 GLN A 176      166.56     56.33                                   
REMARK 500  2 ARG A 177      -39.11   -154.61                                   
REMARK 500  3 ASP A   3     -179.85    -56.81                                   
REMARK 500  3 GLN A   5       79.42   -178.22                                   
REMARK 500  3 SER A   8       40.59   -143.52                                   
REMARK 500  3 SER A  10      123.92     68.59                                   
REMARK 500  3 LYS A  22      108.60    -44.56                                   
REMARK 500  3 HIS A  28      172.09    -50.19                                   
REMARK 500  3 TYR A  29      -53.69   -136.97                                   
REMARK 500  3 GLU A  30      -87.93   -104.31                                   
REMARK 500  3 ARG A  35      -94.00     40.55                                   
REMARK 500  3 ALA A  37      172.25    -46.41                                   
REMARK 500  3 ALA A  40     -154.34   -123.66                                   
REMARK 500  3 SER A  41      -72.48    -69.84                                   
REMARK 500  3 TYR A  53      132.09    177.16                                   
REMARK 500  3 ASN A  56       57.13   -103.73                                   
REMARK 500  3 GLN A  62       78.12   -104.64                                   
REMARK 500  3 ALA A  68      125.37   -170.23                                   
REMARK 500  3 ASP A  70      -56.43   -140.45                                   
REMARK 500  3 ARG A  71      -47.57   -152.14                                   
REMARK 500  3 LEU A  72       89.19    -52.47                                   
REMARK 500  3 LEU A  73      171.93    -48.11                                   
REMARK 500  3 HIS A  82       90.53   -175.83                                   
REMARK 500  3 THR A  85      -95.75   -136.49                                   
REMARK 500  3 SER A  90       31.89    -89.57                                   
REMARK 500  3 THR A  91      -91.09    -91.94                                   
REMARK 500  3 THR A  92       82.02   -174.54                                   
REMARK 500  3 SER A  99       93.82     76.35                                   
REMARK 500  3 THR A 101       80.43   -160.05                                   
REMARK 500  3 PRO A 110       42.54    -81.00                                   
REMARK 500  3 ASN A 112      -70.31   -138.01                                   
REMARK 500  3 SER A 113      101.41    178.19                                   
REMARK 500  3 ASP A 119       53.41   -156.80                                   
REMARK 500  3 CYS A 120       57.07   -141.95                                   
REMARK 500  3 LEU A 126      -93.40   -117.62                                   
REMARK 500  3 ARG A 127      -78.46    170.03                                   
REMARK 500  3 ASP A 130       56.84   -165.07                                   
REMARK 500  3 ARG A 134      144.91    176.15                                   
REMARK 500  3 THR A 138      -44.49   -154.29                                   
REMARK 500  3 ILE A 140      -72.99   -160.01                                   
REMARK 500  3 ARG A 142      170.38     65.25                                   
REMARK 500  3 ASN A 144       93.96     40.64                                   
REMARK 500  3 THR A 145       46.70   -143.47                                   
REMARK 500  3 SER A 159      -75.85    -55.74                                   
REMARK 500  3 THR A 162      -78.23   -136.20                                   
REMARK 500  3 SER A 164       98.27   -162.21                                   
REMARK 500  3 ASN A 170       99.14    176.67                                   
REMARK 500  3 ARG A 177      -83.58   -103.31                                   
REMARK 500  4 ASP A   3      -67.45    174.49                                   
REMARK 500  4 GLN A   5       81.53   -179.75                                   
REMARK 500  4 LEU A   6       62.68   -166.52                                   
REMARK 500  4 SER A   8       46.40   -155.04                                   
REMARK 500  4 SER A  10       52.06   -154.76                                   
REMARK 500  4 PRO A  12     -162.46    -78.04                                   
REMARK 500  4 GLN A  20       79.14   -115.28                                   
REMARK 500  4 ALA A  27       93.46    -60.03                                   
REMARK 500  4 HIS A  28       33.92    176.58                                   
REMARK 500  4 THR A  31       38.23   -145.05                                   
REMARK 500  4 ARG A  35      -89.74    -88.83                                   
REMARK 500  4 ALA A  40      -91.63   -136.34                                   
REMARK 500  4 HIS A  45      123.00   -179.81                                   
REMARK 500  4 GLN A  49      117.74   -161.40                                   
REMARK 500  4 TYR A  53      121.79    175.62                                   
REMARK 500  4 ASN A  56       46.43    -90.83                                   
REMARK 500  4 ASP A  70      -44.13   -166.65                                   
REMARK 500  4 ARG A  71      -36.16   -168.33                                   
REMARK 500  4 LEU A  72       89.41    -53.98                                   
REMARK 500  4 ALA A  77      -72.20    -53.95                                   
REMARK 500  4 GLN A  80       33.86   -174.55                                   
REMARK 500  4 HIS A  82      111.26   -175.58                                   
REMARK 500  4 THR A  85     -154.37    -99.98                                   
REMARK 500  4 LYS A  87       69.56   -155.20                                   
REMARK 500  4 SER A  99      112.22     73.92                                   
REMARK 500  4 THR A 101       88.66   -160.24                                   
REMARK 500  4 SER A 113      107.54    164.72                                   
REMARK 500  4 ASN A 128      118.84   -163.15                                   
REMARK 500  4 ASP A 130       59.42     83.39                                   
REMARK 500  4 LEU A 133      -57.64   -170.98                                   
REMARK 500  4 GLU A 137      -64.45   -122.54                                   
REMARK 500  4 ARG A 142      -85.62   -128.97                                   
REMARK 500  4 THR A 145       53.42   -160.11                                   
REMARK 500  4 THR A 162      -74.18   -140.54                                   
REMARK 500  4 SER A 164       87.14   -163.11                                   
REMARK 500  4 ASN A 170       85.50    163.27                                   
REMARK 500  4 SER A 175      159.11     63.28                                   
REMARK 500  4 ARG A 177     -176.37     48.18                                   
REMARK 500  5 ASP A   3     -162.62     74.13                                   
REMARK 500  5 GLN A   5       85.05    172.94                                   
REMARK 500  5 PRO A  12      -91.83    -77.30                                   
REMARK 500  5 GLU A  14      142.96    179.48                                   
REMARK 500  5 HIS A  25       89.83   -154.49                                   
REMARK 500  5 GLU A  30     -157.70    169.62                                   
REMARK 500  5 SER A  34      -67.58   -101.08                                   
REMARK 500  5 ALA A  40      -88.29   -128.51                                   
REMARK 500  5 SER A  41      -92.20   -114.97                                   
REMARK 500  5 TYR A  53      141.22    -39.18                                   
REMARK 500  5 ASN A  56       49.98    -85.62                                   
REMARK 500  5 PHE A  64     -164.93   -166.16                                   
REMARK 500  5 ASP A  70      -38.75   -142.96                                   
REMARK 500  5 ARG A  71      -35.75   -168.96                                   
REMARK 500  5 LEU A  72       94.73    -44.06                                   
REMARK 500  5 TYR A  79       76.15   -100.72                                   
REMARK 500  5 HIS A  82      107.23   -175.48                                   
REMARK 500  5 THR A  85     -105.17    -99.93                                   
REMARK 500  5 THR A  88       44.85   -155.55                                   
REMARK 500  5 SER A  99      108.03     77.75                                   
REMARK 500  5 THR A 101       79.32   -158.91                                   
REMARK 500  5 PRO A 110       42.33    -81.06                                   
REMARK 500  5 SER A 113       97.39    164.79                                   
REMARK 500  5 ASP A 119       52.35   -156.88                                   
REMARK 500  5 ASN A 128     -165.94   -179.95                                   
REMARK 500  5 SER A 129     -152.87     74.55                                   
REMARK 500  5 ASP A 130       66.24   -179.70                                   
REMARK 500  5 ARG A 134       88.82    174.94                                   
REMARK 500  5 LYS A 135      104.40   -170.79                                   
REMARK 500  5 ASP A 139      -76.84    -71.42                                   
REMARK 500  5 ILE A 140       20.62   -153.34                                   
REMARK 500  5 THR A 145       43.85   -148.19                                   
REMARK 500  5 THR A 162      -90.04   -140.04                                   
REMARK 500  5 SER A 164       94.81   -163.30                                   
REMARK 500  5 VAL A 167       74.49   -151.74                                   
REMARK 500  5 ASN A 170       60.60   -179.69                                   
REMARK 500  5 SER A 175      -94.78    165.18                                   
REMARK 500  5 GLN A 176     -150.63   -157.74                                   
REMARK 500  5 ARG A 177       83.31   -177.30                                   
REMARK 500  6 ASP A   3      -91.70   -133.35                                   
REMARK 500  6 GLN A   5       77.35   -178.95                                   
REMARK 500  6 SER A  10       83.94     75.36                                   
REMARK 500  6 HIS A  28      156.06    -42.21                                   
REMARK 500  6 TYR A  29      -92.77   -132.65                                   
REMARK 500  6 GLU A  30     -154.22     42.89                                   
REMARK 500  6 THR A  31       35.47   -144.09                                   
REMARK 500  6 SER A  34      -87.28    -69.85                                   
REMARK 500  6 ARG A  35     -168.61     60.29                                   
REMARK 500  6 SER A  41     -118.08     43.78                                   
REMARK 500  6 TYR A  53      129.01    178.02                                   
REMARK 500  6 ASN A  56       50.85   -101.83                                   
REMARK 500  6 ALA A  68      124.72   -172.52                                   
REMARK 500  6 ASP A  70      -67.34   -156.08                                   
REMARK 500  6 ARG A  71      -39.18   -144.82                                   
REMARK 500  6 LEU A  72       88.92    -51.84                                   
REMARK 500  6 TYR A  79       74.26   -101.46                                   
REMARK 500  6 HIS A  82      114.05   -176.30                                   
REMARK 500  6 THR A  85     -149.27   -145.05                                   
REMARK 500  6 THR A  88     -164.99   -112.80                                   
REMARK 500  6 SER A  90       31.64   -165.53                                   
REMARK 500  6 SER A  99      117.44     62.29                                   
REMARK 500  6 THR A 101       85.16   -159.32                                   
REMARK 500  6 PRO A 110       30.53    -81.84                                   
REMARK 500  6 GLU A 111       49.95   -102.96                                   
REMARK 500  6 ASN A 112      -61.63   -161.78                                   
REMARK 500  6 SER A 113       89.90    167.80                                   
REMARK 500  6 ASP A 119       46.61   -175.28                                   
REMARK 500  6 LEU A 126     -165.67   -104.99                                   
REMARK 500  6 ARG A 127     -147.69   -166.14                                   
REMARK 500  6 SER A 129     -167.99    178.95                                   
REMARK 500  6 ASP A 130       60.43   -172.19                                   
REMARK 500  6 LYS A 135      174.77    173.99                                   
REMARK 500  6 ASP A 139      -39.33   -153.81                                   
REMARK 500  6 ILE A 140       30.06   -142.83                                   
REMARK 500  6 ARG A 142      -41.71   -150.93                                   
REMARK 500  6 THR A 145       53.02   -157.59                                   
REMARK 500  6 SER A 159      -93.51    -59.38                                   
REMARK 500  6 THR A 162      -90.17   -138.90                                   
REMARK 500  6 SER A 164       91.49   -162.94                                   
REMARK 500  6 ASN A 170       63.04   -174.51                                   
REMARK 500  6 SER A 175     -149.04    178.89                                   
REMARK 500  6 ARG A 177      -76.06    -50.68                                   
REMARK 500  7 LYS A   2     -170.16     46.14                                   
REMARK 500  7 ASP A   3      -95.36   -135.45                                   
REMARK 500  7 GLN A   5       75.37   -179.22                                   
REMARK 500  7 SER A  10      118.95   -179.43                                   
REMARK 500  7 GLU A  14      139.16    179.72                                   
REMARK 500  7 LYS A  22       94.44    -48.45                                   
REMARK 500  7 SER A  23       40.24    -94.02                                   
REMARK 500  7 ARG A  26       75.73   -106.10                                   
REMARK 500  7 TYR A  29       69.32   -166.51                                   
REMARK 500  7 THR A  31       59.77   -145.49                                   
REMARK 500  7 SER A  41      -88.21     50.91                                   
REMARK 500  7 ALA A  42       46.25    -85.03                                   
REMARK 500  7 TYR A  53      121.86    -38.37                                   
REMARK 500  7 ASN A  56       44.68    -84.61                                   
REMARK 500  7 ASP A  70      -52.48   -136.43                                   
REMARK 500  7 ARG A  71      -34.96   -175.17                                   
REMARK 500  7 LEU A  72       91.43    -55.90                                   
REMARK 500  7 LEU A  73      166.64    -47.39                                   
REMARK 500  7 ALA A  77      -78.72    -78.11                                   
REMARK 500  7 GLN A  80       30.46   -167.32                                   
REMARK 500  7 HIS A  82       66.73   -176.06                                   
REMARK 500  7 THR A  88     -165.03   -165.32                                   
REMARK 500  7 SER A  90       32.07    -90.39                                   
REMARK 500  7 THR A  92      106.11    -52.55                                   
REMARK 500  7 SER A  99      104.17     77.08                                   
REMARK 500  7 THR A 101       77.64   -159.30                                   
REMARK 500  7 GLU A 111      -49.30   -138.60                                   
REMARK 500  7 SER A 113       98.69   -175.53                                   
REMARK 500  7 MET A 114      108.46   -165.80                                   
REMARK 500  7 ASP A 119       28.57   -163.12                                   
REMARK 500  7 ARG A 127      -93.98     44.46                                   
REMARK 500  7 ASN A 128       60.22   -153.68                                   
REMARK 500  7 ASP A 130       64.96   -179.92                                   
REMARK 500  7 LYS A 135       91.57    -52.22                                   
REMARK 500  7 ASP A 139      132.20     61.70                                   
REMARK 500  7 ARG A 142       32.06   -144.20                                   
REMARK 500  7 ASN A 144      133.19     58.12                                   
REMARK 500  7 THR A 145       53.86   -160.23                                   
REMARK 500  7 SER A 159     -148.37    -59.22                                   
REMARK 500  7 SER A 164      101.71   -162.86                                   
REMARK 500  7 ASN A 170       73.72    163.03                                   
REMARK 500  7 CYS A 174     -168.55   -119.59                                   
REMARK 500  7 SER A 175       30.70   -164.76                                   
REMARK 500  7 GLN A 176       27.97     44.14                                   
REMARK 500  7 ARG A 177       98.80     76.18                                   
REMARK 500  8 ASP A   3      117.75   -178.05                                   
REMARK 500  8 GLN A   5       82.12   -178.03                                   
REMARK 500  8 LEU A   6       97.03   -163.19                                   
REMARK 500  8 SER A   8       58.64   -154.01                                   
REMARK 500  8 SER A  10       54.70   -177.82                                   
REMARK 500  8 GLN A  20       77.16   -119.05                                   
REMARK 500  8 LYS A  22       99.36    -44.35                                   
REMARK 500  8 SER A  23       40.92    -96.63                                   
REMARK 500  8 ARG A  26       74.31   -105.68                                   
REMARK 500  8 TYR A  29     -145.04   -120.94                                   
REMARK 500  8 GLU A  30      -84.70    -43.88                                   
REMARK 500  8 THR A  31       48.06   -141.87                                   
REMARK 500  8 SER A  34     -147.93    -84.20                                   
REMARK 500  8 ALA A  40     -147.21    -93.85                                   
REMARK 500  8 HIS A  45      177.67    165.42                                   
REMARK 500  8 TYR A  53      118.61    177.00                                   
REMARK 500  8 ASN A  56       35.92    -89.00                                   
REMARK 500  8 ALA A  68      113.58   -169.06                                   
REMARK 500  8 ASP A  70      -54.39   -168.67                                   
REMARK 500  8 ARG A  71      -33.62   -175.23                                   
REMARK 500  8 LEU A  72       92.05    -54.12                                   
REMARK 500  8 ALA A  77      -77.88    -46.02                                   
REMARK 500  8 PHE A  78       23.71   -140.66                                   
REMARK 500  8 HIS A  82       85.45   -175.96                                   
REMARK 500  8 ARG A  83       81.04   -150.21                                   
REMARK 500  8 THR A  91     -168.96    -72.86                                   
REMARK 500  8 SER A  99      114.85     74.34                                   
REMARK 500  8 ASN A 112      -65.11   -143.55                                   
REMARK 500  8 SER A 113      109.95    164.61                                   
REMARK 500  8 ASP A 119       47.39   -147.56                                   
REMARK 500  8 CYS A 120       54.20   -145.04                                   
REMARK 500  8 LYS A 125       65.68   -108.74                                   
REMARK 500  8 ARG A 127     -155.90   -141.91                                   
REMARK 500  8 ASN A 128      -50.82   -153.19                                   
REMARK 500  8 SER A 129      -94.71     44.31                                   
REMARK 500  8 ASP A 130       59.51    177.17                                   
REMARK 500  8 ARG A 134      -38.17   -174.37                                   
REMARK 500  8 THR A 138       57.73   -148.96                                   
REMARK 500  8 ILE A 140       34.87   -147.73                                   
REMARK 500  8 THR A 145       47.50   -160.47                                   
REMARK 500  8 SER A 159      171.48    -45.71                                   
REMARK 500  8 THR A 162     -108.34   -102.03                                   
REMARK 500  8 SER A 164      100.34   -162.85                                   
REMARK 500  8 ASN A 170       94.94    172.20                                   
REMARK 500  8 SER A 175      -33.04    176.47                                   
REMARK 500  8 GLN A 176       95.35    -44.38                                   
REMARK 500  9 LYS A   2       40.42   -151.80                                   
REMARK 500  9 ASP A   3     -156.46   -174.95                                   
REMARK 500  9 GLN A   5       90.41    163.04                                   
REMARK 500  9 SER A   8       43.97   -142.61                                   
REMARK 500  9 LEU A  15       76.78   -112.24                                   
REMARK 500  9 SER A  23       61.58   -163.76                                   
REMARK 500  9 HIS A  28      113.12    174.63                                   
REMARK 500  9 TYR A  29      171.97    169.55                                   
REMARK 500  9 GLU A  30       31.35   -161.40                                   
REMARK 500  9 THR A  31       43.45   -144.63                                   
REMARK 500  9 GLU A  32      -41.31   -133.70                                   
REMARK 500  9 ARG A  35       70.76    172.48                                   
REMARK 500  9 ALA A  40      -45.25   -160.66                                   
REMARK 500  9 HIS A  45      146.18     73.92                                   
REMARK 500  9 TYR A  53      131.83    176.80                                   
REMARK 500  9 ASN A  56       35.12    -90.73                                   
REMARK 500  9 ALA A  68      116.99   -160.56                                   
REMARK 500  9 ASP A  70      -42.02   -146.12                                   
REMARK 500  9 ARG A  71      -34.13   -175.35                                   
REMARK 500  9 LEU A  72       91.29    -48.67                                   
REMARK 500  9 GLN A  80      -36.41   -165.05                                   
REMARK 500  9 HIS A  82       67.98   -175.93                                   
REMARK 500  9 SER A  99      112.34     76.80                                   
REMARK 500  9 THR A 101       96.29   -160.20                                   
REMARK 500  9 PRO A 110      -76.51    -77.64                                   
REMARK 500  9 GLU A 111       52.20   -170.46                                   
REMARK 500  9 SER A 113       87.89    164.68                                   
REMARK 500  9 ASP A 119       41.83   -147.12                                   
REMARK 500  9 CYS A 120       57.77   -145.22                                   
REMARK 500  9 ARG A 127       28.53   -160.70                                   
REMARK 500  9 SER A 129      -85.43   -137.11                                   
REMARK 500  9 ASP A 130       59.32     83.45                                   
REMARK 500  9 GLU A 132      111.18   -169.57                                   
REMARK 500  9 ARG A 134     -168.40   -178.55                                   
REMARK 500  9 THR A 138     -166.32   -125.31                                   
REMARK 500  9 ASP A 139      -85.97    -76.74                                   
REMARK 500  9 ASN A 144      137.91     66.20                                   
REMARK 500  9 THR A 145       53.02   -159.38                                   
REMARK 500  9 SER A 159      -78.26    -53.77                                   
REMARK 500  9 THR A 162      -88.38   -135.05                                   
REMARK 500  9 SER A 164      114.31   -162.11                                   
REMARK 500  9 ASN A 170       97.77    164.93                                   
REMARK 500  9 SER A 175      -42.78     82.57                                   
REMARK 500  9 GLN A 176       78.68     70.32                                   
REMARK 500  9 ARG A 177      -44.91   -168.93                                   
REMARK 500 10 ASP A   3      169.44     62.02                                   
REMARK 500 10 GLN A   5       83.40    176.56                                   
REMARK 500 10 SER A  10      146.69     73.35                                   
REMARK 500 10 PRO A  12     -158.79    -77.50                                   
REMARK 500 10 LYS A  22      165.12    -46.09                                   
REMARK 500 10 HIS A  25      106.76   -162.48                                   
REMARK 500 10 HIS A  28       38.26    169.97                                   
REMARK 500 10 TYR A  29      -70.32   -129.54                                   
REMARK 500 10 THR A  31       36.32   -145.10                                   
REMARK 500 10 GLU A  32       52.32   -140.05                                   
REMARK 500 10 ARG A  35      -90.13     52.01                                   
REMARK 500 10 ALA A  40      105.80   -161.16                                   
REMARK 500 10 SER A  41     -105.56     44.17                                   
REMARK 500 10 ALA A  42       48.00    -88.57                                   
REMARK 500 10 TYR A  53      156.95    175.90                                   
REMARK 500 10 LEU A  54       11.02   -140.71                                   
REMARK 500 10 ASN A  56       35.81    -90.25                                   
REMARK 500 10 ASP A  70      -44.34   -159.91                                   
REMARK 500 10 ARG A  71      -34.14   -175.08                                   
REMARK 500 10 LEU A  72       89.14    -52.08                                   
REMARK 500 10 GLN A  80       10.11   -143.66                                   
REMARK 500 10 HIS A  82       67.75   -175.49                                   
REMARK 500 10 THR A  85     -163.88   -126.41                                   
REMARK 500 10 THR A  91      -83.01    -80.75                                   
REMARK 500 10 THR A  92      162.46    179.33                                   
REMARK 500 10 SER A  99       83.98     35.07                                   
REMARK 500 10 ASN A 100       29.42     42.72                                   
REMARK 500 10 LEU A 109       78.56   -115.03                                   
REMARK 500 10 PRO A 110       40.13    -83.25                                   
REMARK 500 10 ASN A 112      -52.90   -122.32                                   
REMARK 500 10 SER A 113       86.01    164.59                                   
REMARK 500 10 ASP A 119       57.60   -171.66                                   
REMARK 500 10 CYS A 120       43.73   -145.19                                   
REMARK 500 10 ARG A 127      160.18     63.69                                   
REMARK 500 10 ASP A 130       63.82    167.32                                   
REMARK 500 10 ARG A 134     -168.29    -65.99                                   
REMARK 500 10 LYS A 135      106.78    -44.03                                   
REMARK 500 10 GLU A 137      -34.59   -177.30                                   
REMARK 500 10 ASP A 139       99.79     66.54                                   
REMARK 500 10 ILE A 140       42.24   -177.84                                   
REMARK 500 10 ARG A 142       37.19     38.52                                   
REMARK 500 10 ASN A 144      163.28     67.38                                   
REMARK 500 10 THR A 145       52.45   -156.73                                   
REMARK 500 10 SER A 159      -90.19    -64.91                                   
REMARK 500 10 THR A 162      -82.21   -134.97                                   
REMARK 500 10 SER A 164       85.02   -164.95                                   
REMARK 500 10 SER A 169      133.96   -175.30                                   
REMARK 500 10 ASN A 170       97.72    170.03                                   
REMARK 500 10 SER A 175      113.39     65.64                                   
REMARK 500 10 GLN A 176     -153.29   -131.53                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  1 ARG A  16         0.21    SIDE_CHAIN                              
REMARK 500  1 ARG A  26         0.28    SIDE_CHAIN                              
REMARK 500  1 ARG A  35         0.31    SIDE_CHAIN                              
REMARK 500  1 ARG A  71         0.24    SIDE_CHAIN                              
REMARK 500  1 ARG A  74         0.31    SIDE_CHAIN                              
REMARK 500  1 ARG A  83         0.22    SIDE_CHAIN                              
REMARK 500  1 ARG A 115         0.32    SIDE_CHAIN                              
REMARK 500  1 ARG A 127         0.11    SIDE_CHAIN                              
REMARK 500  1 ARG A 134         0.32    SIDE_CHAIN                              
REMARK 500  1 ARG A 142         0.23    SIDE_CHAIN                              
REMARK 500  1 ARG A 146         0.17    SIDE_CHAIN                              
REMARK 500  1 ARG A 148         0.30    SIDE_CHAIN                              
REMARK 500  1 ARG A 152         0.31    SIDE_CHAIN                              
REMARK 500  1 ARG A 161         0.16    SIDE_CHAIN                              
REMARK 500  1 ARG A 177         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A  16         0.31    SIDE_CHAIN                              
REMARK 500  2 ARG A  26         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A  35         0.13    SIDE_CHAIN                              
REMARK 500  2 ARG A  71         0.23    SIDE_CHAIN                              
REMARK 500  2 ARG A  74         0.16    SIDE_CHAIN                              
REMARK 500  2 ARG A  83         0.12    SIDE_CHAIN                              
REMARK 500  2 ARG A 115         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A 127         0.15    SIDE_CHAIN                              
REMARK 500  2 ARG A 134         0.25    SIDE_CHAIN                              
REMARK 500  2 ARG A 142         0.15    SIDE_CHAIN                              
REMARK 500  2 ARG A 146         0.11    SIDE_CHAIN                              
REMARK 500  2 ARG A 148         0.10    SIDE_CHAIN                              
REMARK 500  2 ARG A 152         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A 161         0.32    SIDE_CHAIN                              
REMARK 500  2 ARG A 177         0.24    SIDE_CHAIN                              
REMARK 500  3 ARG A  16         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A  26         0.21    SIDE_CHAIN                              
REMARK 500  3 ARG A  35         0.24    SIDE_CHAIN                              
REMARK 500  3 ARG A  71         0.24    SIDE_CHAIN                              
REMARK 500  3 ARG A  74         0.18    SIDE_CHAIN                              
REMARK 500  3 ARG A 115         0.32    SIDE_CHAIN                              
REMARK 500  3 ARG A 127         0.30    SIDE_CHAIN                              
REMARK 500  3 ARG A 134         0.29    SIDE_CHAIN                              
REMARK 500  3 ARG A 142         0.18    SIDE_CHAIN                              
REMARK 500  3 ARG A 146         0.26    SIDE_CHAIN                              
REMARK 500  3 ARG A 148         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A 152         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A 161         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A 177         0.20    SIDE_CHAIN                              
REMARK 500  4 ARG A  16         0.13    SIDE_CHAIN                              
REMARK 500  4 ARG A  26         0.13    SIDE_CHAIN                              
REMARK 500  4 ARG A  35         0.26    SIDE_CHAIN                              
REMARK 500  4 ARG A  71         0.23    SIDE_CHAIN                              
REMARK 500  4 ARG A  74         0.16    SIDE_CHAIN                              
REMARK 500  4 ARG A  83         0.32    SIDE_CHAIN                              
REMARK 500  4 ARG A 115         0.24    SIDE_CHAIN                              
REMARK 500  4 ARG A 127         0.28    SIDE_CHAIN                              
REMARK 500  4 ARG A 134         0.30    SIDE_CHAIN                              
REMARK 500  4 ARG A 142         0.31    SIDE_CHAIN                              
REMARK 500  4 ARG A 146         0.32    SIDE_CHAIN                              
REMARK 500  4 ARG A 148         0.25    SIDE_CHAIN                              
REMARK 500  4 ARG A 152         0.30    SIDE_CHAIN                              
REMARK 500  4 ARG A 161         0.17    SIDE_CHAIN                              
REMARK 500  4 ARG A 177         0.24    SIDE_CHAIN                              
REMARK 500  5 ARG A  16         0.23    SIDE_CHAIN                              
REMARK 500  5 ARG A  35         0.26    SIDE_CHAIN                              
REMARK 500  5 ARG A  71         0.32    SIDE_CHAIN                              
REMARK 500  5 ARG A  74         0.29    SIDE_CHAIN                              
REMARK 500  5 ARG A  83         0.27    SIDE_CHAIN                              
REMARK 500  5 ARG A 115         0.20    SIDE_CHAIN                              
REMARK 500  5 ARG A 127         0.15    SIDE_CHAIN                              
REMARK 500  5 ARG A 134         0.31    SIDE_CHAIN                              
REMARK 500  5 ARG A 142         0.26    SIDE_CHAIN                              
REMARK 500  5 ARG A 146         0.29    SIDE_CHAIN                              
REMARK 500  5 ARG A 148         0.17    SIDE_CHAIN                              
REMARK 500  5 ARG A 152         0.32    SIDE_CHAIN                              
REMARK 500  5 ARG A 161         0.26    SIDE_CHAIN                              
REMARK 500  5 ARG A 177         0.29    SIDE_CHAIN                              
REMARK 500  6 ARG A  16         0.18    SIDE_CHAIN                              
REMARK 500  6 ARG A  26         0.29    SIDE_CHAIN                              
REMARK 500  6 ARG A  35         0.30    SIDE_CHAIN                              
REMARK 500  6 ARG A  71         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG A  74         0.22    SIDE_CHAIN                              
REMARK 500  6 ARG A  83         0.27    SIDE_CHAIN                              
REMARK 500  6 ARG A 115         0.27    SIDE_CHAIN                              
REMARK 500  6 ARG A 127         0.20    SIDE_CHAIN                              
REMARK 500  6 ARG A 134         0.31    SIDE_CHAIN                              
REMARK 500  6 ARG A 142         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG A 146         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG A 148         0.09    SIDE_CHAIN                              
REMARK 500  6 ARG A 152         0.31    SIDE_CHAIN                              
REMARK 500  6 ARG A 161         0.28    SIDE_CHAIN                              
REMARK 500  6 ARG A 177         0.32    SIDE_CHAIN                              
REMARK 500  7 ARG A  16         0.22    SIDE_CHAIN                              
REMARK 500  7 ARG A  26         0.30    SIDE_CHAIN                              
REMARK 500  7 ARG A  35         0.13    SIDE_CHAIN                              
REMARK 500  7 ARG A  71         0.24    SIDE_CHAIN                              
REMARK 500  7 ARG A  74         0.26    SIDE_CHAIN                              
REMARK 500  7 ARG A  83         0.10    SIDE_CHAIN                              
REMARK 500  7 ARG A 115         0.30    SIDE_CHAIN                              
REMARK 500  7 ARG A 127         0.32    SIDE_CHAIN                              
REMARK 500  7 ARG A 134         0.29    SIDE_CHAIN                              
REMARK 500  7 ARG A 142         0.26    SIDE_CHAIN                              
REMARK 500  7 ARG A 146         0.30    SIDE_CHAIN                              
REMARK 500  7 ARG A 148         0.10    SIDE_CHAIN                              
REMARK 500  7 ARG A 152         0.29    SIDE_CHAIN                              
REMARK 500  7 ARG A 161         0.31    SIDE_CHAIN                              
REMARK 500  7 ARG A 177         0.19    SIDE_CHAIN                              
REMARK 500  8 ARG A  16         0.31    SIDE_CHAIN                              
REMARK 500  8 ARG A  26         0.12    SIDE_CHAIN                              
REMARK 500  8 ARG A  35         0.29    SIDE_CHAIN                              
REMARK 500  8 ARG A  71         0.30    SIDE_CHAIN                              
REMARK 500  8 ARG A  74         0.31    SIDE_CHAIN                              
REMARK 500  8 ARG A  83         0.22    SIDE_CHAIN                              
REMARK 500  8 ARG A 115         0.12    SIDE_CHAIN                              
REMARK 500  8 ARG A 127         0.30    SIDE_CHAIN                              
REMARK 500  8 ARG A 134         0.23    SIDE_CHAIN                              
REMARK 500  8 ARG A 142         0.20    SIDE_CHAIN                              
REMARK 500  8 ARG A 146         0.09    SIDE_CHAIN                              
REMARK 500  8 ARG A 148         0.25    SIDE_CHAIN                              
REMARK 500  8 ARG A 152         0.13    SIDE_CHAIN                              
REMARK 500  8 ARG A 161         0.19    SIDE_CHAIN                              
REMARK 500  8 ARG A 177         0.31    SIDE_CHAIN                              
REMARK 500  9 ARG A  16         0.15    SIDE_CHAIN                              
REMARK 500  9 ARG A  26         0.31    SIDE_CHAIN                              
REMARK 500  9 ARG A  35         0.31    SIDE_CHAIN                              
REMARK 500  9 ARG A  71         0.17    SIDE_CHAIN                              
REMARK 500  9 ARG A  74         0.28    SIDE_CHAIN                              
REMARK 500  9 ARG A  83         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A 115         0.08    SIDE_CHAIN                              
REMARK 500  9 ARG A 127         0.27    SIDE_CHAIN                              
REMARK 500  9 ARG A 134         0.20    SIDE_CHAIN                              
REMARK 500  9 ARG A 142         0.14    SIDE_CHAIN                              
REMARK 500  9 ARG A 146         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A 148         0.31    SIDE_CHAIN                              
REMARK 500  9 ARG A 152         0.28    SIDE_CHAIN                              
REMARK 500  9 ARG A 161         0.24    SIDE_CHAIN                              
REMARK 500  9 ARG A 177         0.32    SIDE_CHAIN                              
REMARK 500 10 ARG A  16         0.31    SIDE_CHAIN                              
REMARK 500 10 ARG A  26         0.20    SIDE_CHAIN                              
REMARK 500 10 ARG A  35         0.20    SIDE_CHAIN                              
REMARK 500 10 ARG A  71         0.18    SIDE_CHAIN                              
REMARK 500 10 ARG A  74         0.30    SIDE_CHAIN                              
REMARK 500 10 ARG A  83         0.18    SIDE_CHAIN                              
REMARK 500 10 ARG A 115         0.26    SIDE_CHAIN                              
REMARK 500 10 ARG A 127         0.32    SIDE_CHAIN                              
REMARK 500 10 ARG A 134         0.24    SIDE_CHAIN                              
REMARK 500 10 ARG A 142         0.29    SIDE_CHAIN                              
REMARK 500 10 ARG A 146         0.28    SIDE_CHAIN                              
REMARK 500 10 ARG A 148         0.31    SIDE_CHAIN                              
REMARK 500 10 ARG A 161         0.26    SIDE_CHAIN                              
REMARK 500 10 ARG A 177         0.28    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  1NFA A    3   178  UNP    O95644   NFAC1_HUMAN    416    591             
SEQRES   1 A  178  MET LYS ASP TRP GLN LEU PRO SER HIS SER GLY PRO TYR          
SEQRES   2 A  178  GLU LEU ARG ILE GLU VAL GLN PRO LYS SER HIS HIS ARG          
SEQRES   3 A  178  ALA HIS TYR GLU THR GLU GLY SER ARG GLY ALA VAL LYS          
SEQRES   4 A  178  ALA SER ALA GLY GLY HIS PRO ILE VAL GLN LEU HIS GLY          
SEQRES   5 A  178  TYR LEU GLU ASN GLU PRO LEU MET LEU GLN LEU PHE ILE          
SEQRES   6 A  178  GLY THR ALA ASP ASP ARG LEU LEU ARG PRO HIS ALA PHE          
SEQRES   7 A  178  TYR GLN VAL HIS ARG ILE THR GLY LYS THR VAL SER THR          
SEQRES   8 A  178  THR SER HIS GLU ALA ILE LEU SER ASN THR LYS VAL LEU          
SEQRES   9 A  178  GLU ILE PRO LEU LEU PRO GLU ASN SER MET ARG ALA VAL          
SEQRES  10 A  178  ILE ASP CYS ALA GLY ILE LEU LYS LEU ARG ASN SER ASP          
SEQRES  11 A  178  ILE GLU LEU ARG LYS GLY GLU THR ASP ILE GLY ARG LYS          
SEQRES  12 A  178  ASN THR ARG VAL ARG LEU VAL PHE ARG VAL HIS VAL PRO          
SEQRES  13 A  178  GLN PRO SER GLY ARG THR LEU SER LEU GLN VAL ALA SER          
SEQRES  14 A  178  ASN PRO ILE GLU CYS SER GLN ARG SER                          
HELIX    1   1 ALA A   40  GLY A   44  5                                   5    
SHEET    1   A 4 ARG A 148  ARG A 152  0                                        
SHEET    2   A 4 PRO A  58  GLY A  66 -1  N  GLY A  66   O  ARG A 148           
SHEET    3   A 4 LYS A 102  LEU A 109 -1  N  LEU A 108   O  LEU A  59           
SHEET    4   A 4 GLU A  95  ILE A  97 -1  N  ALA A  96   O  VAL A 103           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system