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Database: PDB
Entry: 3P8C
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Original site: 3P8C 
HEADER    PROTEIN BINDING                         13-OCT-10   3P8C              
TITLE     STRUCTURE AND CONTROL OF THE ACTIN REGULATORY WAVE COMPLEX            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CYTOPLASMIC FMR1-INTERACTING PROTEIN 1;                    
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: SPECIFICALLY RAC1-ASSOCIATED PROTEIN 1, SRA-1, P140SRA-1;   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: NCK-ASSOCIATED PROTEIN 1;                                  
COMPND   8 CHAIN: B;                                                            
COMPND   9 SYNONYM: NAP 1, MEMBRANE-ASSOCIATED PROTEIN HEM-2, P125NAP1;         
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 1;          
COMPND  13 CHAIN: D;                                                            
COMPND  14 SYNONYM: WASP FAMILY PROTEIN MEMBER 1, PROTEIN WAVE-1, VERPROLIN     
COMPND  15 HOMOLOGY DOMAIN-CONTAINING PROTEIN 1;                                
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MUTATION: YES;                                                       
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: PROBABLE PROTEIN BRICK1;                                   
COMPND  20 CHAIN: E;                                                            
COMPND  21 ENGINEERED: YES;                                                     
COMPND  22 MOL_ID: 5;                                                           
COMPND  23 MOLECULE: ABL INTERACTOR 2;                                          
COMPND  24 CHAIN: F;                                                            
COMPND  25 FRAGMENT: N-TERMINAL DOMAIN;                                         
COMPND  26 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: CYFIP1, KIAA0068;                                              
SOURCE   6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: NCKAP1, HEM2, KIAA0587, NAP1;                                  
SOURCE  13 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: WASF1, KIAA0269, SCAR1, WAVE1;                                 
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: C3ORF10, HSPC300, MDS027;                                      
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  34 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    ACTIN POLYMERIZATION, PROTEIN BINDING                                 
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Z.CHEN,D.BOREK,S.B.PADRICK,T.S.GOMEZ,Z.METLAGEL,A.M.ISMAIL,J.UMETANI, 
AUTHOR   2 D.D.BILLADEAU,Z.OTWINOWSKI,M.K.ROSEN                                 
REVDAT   3   02-AUG-17 3P8C    1       SOURCE REMARK                            
REVDAT   2   21-SEP-11 3P8C    1       JRNL   VERSN  AUTHOR                     
REVDAT   1   01-DEC-10 3P8C    0                                                
JRNL        AUTH   Z.CHEN,D.BOREK,S.B.PADRICK,T.S.GOMEZ,Z.METLAGEL,A.M.ISMAIL,  
JRNL        AUTH 2 J.UMETANI,D.D.BILLADEAU,Z.OTWINOWSKI,M.K.ROSEN               
JRNL        TITL   STRUCTURE AND CONTROL OF THE ACTIN REGULATORY WAVE COMPLEX.  
JRNL        REF    NATURE                        V. 468   533 2010              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   21107423                                                     
JRNL        DOI    10.1038/NATURE09623                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.29 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.5.0102                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.29                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.98                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 86.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 135310                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.191                           
REMARK   3   R VALUE            (WORKING SET) : 0.188                           
REMARK   3   FREE R VALUE                     : 0.237                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 7144                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.29                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.35                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 3707                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 32.57                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2250                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 192                          
REMARK   3   BIN FREE R VALUE                    : 0.3040                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 21789                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 39                                      
REMARK   3   SOLVENT ATOMS            : 957                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 33.40                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 18.08                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.04000                                             
REMARK   3    B22 (A**2) : 0.00000                                              
REMARK   3    B33 (A**2) : 0.04000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.239         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.160         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 14.763        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.949                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.924                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 22499 ; 0.006 ; 0.022       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 30406 ; 0.879 ; 1.965       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  2721 ; 4.080 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  1080 ;36.105 ;24.019       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  4188 ;14.168 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   159 ;13.692 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  3416 ; 0.063 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 16796 ; 0.003 ; 0.021       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 13575 ; 5.387 ; 4.000       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 22040 ; 7.122 ; 6.000       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  8924 ; 7.107 ; 4.000       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  8365 ; 9.230 ; 6.000       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 91                                         
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A     5        A    68                          
REMARK   3    ORIGIN FOR THE GROUP (A):  46.8161  55.8169 255.3159              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6491 T22:   0.6580                                     
REMARK   3      T33:   0.4672 T12:  -0.0705                                     
REMARK   3      T13:   0.0052 T23:  -0.0139                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2348 L22:   1.9219                                     
REMARK   3      L33:   0.0211 L12:   2.3992                                     
REMARK   3      L13:   0.0536 L23:   0.0596                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2236 S12:  -0.5112 S13:   0.2127                       
REMARK   3      S21:   0.2069 S22:  -0.2177 S23:  -0.0428                       
REMARK   3      S31:  -0.0822 S32:   0.0650 S33:  -0.0059                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A    69        A   147                          
REMARK   3    ORIGIN FOR THE GROUP (A):   2.0814  45.4123 243.4625              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5506 T22:   0.4850                                     
REMARK   3      T33:   0.4657 T12:   0.0662                                     
REMARK   3      T13:   0.0717 T23:   0.0131                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9352 L22:   2.0147                                     
REMARK   3      L33:   2.4363 L12:   0.7516                                     
REMARK   3      L13:   0.6228 L23:   0.3593                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0760 S12:  -0.2324 S13:   0.0815                       
REMARK   3      S21:   0.0202 S22:  -0.0464 S23:   0.2323                       
REMARK   3      S31:   0.0182 S32:  -0.3344 S33:   0.1224                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   148        A   171                          
REMARK   3    ORIGIN FOR THE GROUP (A):  25.9973  52.2701 249.8193              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5529 T22:   0.5252                                     
REMARK   3      T33:   0.4164 T12:   0.0241                                     
REMARK   3      T13:  -0.0556 T23:  -0.0137                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.3037 L22:   3.5453                                     
REMARK   3      L33:   2.0679 L12:  -1.4849                                     
REMARK   3      L13:  -0.3248 L23:  -1.7050                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1867 S12:  -0.7692 S13:   0.4503                       
REMARK   3      S21:   0.6646 S22:  -0.0384 S23:  -0.4609                       
REMARK   3      S31:  -0.4127 S32:   0.3351 S33:   0.2251                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   172        A   216                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.8650  49.7097 243.3687              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6012 T22:   0.5556                                     
REMARK   3      T33:   0.5657 T12:   0.1156                                     
REMARK   3      T13:   0.0388 T23:  -0.0139                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.0038 L22:   3.0701                                     
REMARK   3      L33:   4.6429 L12:   0.7979                                     
REMARK   3      L13:  -1.8425 L23:   0.7554                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0926 S12:  -0.5776 S13:   0.1210                       
REMARK   3      S21:   0.5392 S22:  -0.0405 S23:   0.7397                       
REMARK   3      S31:   0.0875 S32:  -0.5771 S33:   0.1330                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   217        A   313                          
REMARK   3    ORIGIN FOR THE GROUP (A):  25.7049  58.7326 239.9456              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4977 T22:   0.4915                                     
REMARK   3      T33:   0.4469 T12:   0.0082                                     
REMARK   3      T13:  -0.0561 T23:  -0.0108                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2188 L22:   1.4639                                     
REMARK   3      L33:   1.2275 L12:   0.1728                                     
REMARK   3      L13:   0.2066 L23:   0.2002                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0816 S12:  -0.1781 S13:   0.2479                       
REMARK   3      S21:   0.1158 S22:   0.0365 S23:  -0.0982                       
REMARK   3      S31:  -0.2638 S32:   0.1146 S33:   0.0450                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   314        A   346                          
REMARK   3    ORIGIN FOR THE GROUP (A):  23.2358  66.5813 230.5205              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5715 T22:   0.4933                                     
REMARK   3      T33:   0.4219 T12:  -0.0340                                     
REMARK   3      T13:  -0.0859 T23:   0.0183                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9350 L22:   5.7970                                     
REMARK   3      L33:   1.2694 L12:  -2.1964                                     
REMARK   3      L13:  -0.9854 L23:   1.8108                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0556 S12:   0.2723 S13:   0.2334                       
REMARK   3      S21:  -0.4376 S22:  -0.0577 S23:  -0.2414                       
REMARK   3      S31:  -0.2769 S32:   0.0720 S33:   0.0022                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   347        A   381                          
REMARK   3    ORIGIN FOR THE GROUP (A):  43.6476  35.4281 221.6051              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4390 T22:   0.5299                                     
REMARK   3      T33:   0.4801 T12:  -0.0407                                     
REMARK   3      T13:   0.0154 T23:  -0.0392                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5641 L22:   5.3369                                     
REMARK   3      L33:   8.9060 L12:  -2.9699                                     
REMARK   3      L13:   3.4813 L23:  -4.0531                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0859 S12:   0.0399 S13:   0.2092                       
REMARK   3      S21:   0.1745 S22:  -0.1723 S23:  -0.4700                       
REMARK   3      S31:  -0.0450 S32:   0.4403 S33:   0.2582                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   382        A   442                          
REMARK   3    ORIGIN FOR THE GROUP (A):  27.2803  44.8177 221.7031              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4987 T22:   0.4672                                     
REMARK   3      T33:   0.4653 T12:  -0.0334                                     
REMARK   3      T13:   0.0322 T23:  -0.0139                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0619 L22:   1.8070                                     
REMARK   3      L33:   2.5622 L12:  -1.3698                                     
REMARK   3      L13:   1.8588 L23:  -0.8495                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0231 S12:   0.3064 S13:   0.2628                       
REMARK   3      S21:  -0.1160 S22:  -0.1500 S23:  -0.0673                       
REMARK   3      S31:  -0.0724 S32:   0.1301 S33:   0.1269                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   443        A   521                          
REMARK   3    ORIGIN FOR THE GROUP (A):  42.5562  36.9769 243.2803              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5096 T22:   0.5595                                     
REMARK   3      T33:   0.5486 T12:   0.0041                                     
REMARK   3      T13:  -0.0116 T23:   0.0102                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1707 L22:   0.7712                                     
REMARK   3      L33:   2.4782 L12:  -0.4115                                     
REMARK   3      L13:   0.9246 L23:  -0.4710                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0751 S12:  -0.2118 S13:   0.1178                       
REMARK   3      S21:   0.2292 S22:  -0.0096 S23:  -0.2077                       
REMARK   3      S31:  -0.0965 S32:   0.2655 S33:   0.0848                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   522        A   571                          
REMARK   3    ORIGIN FOR THE GROUP (A):  49.9492  35.4231 258.2994              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4530 T22:   0.9529                                     
REMARK   3      T33:   0.3253 T12:   0.0833                                     
REMARK   3      T13:  -0.1895 T23:   0.0979                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9496 L22:   4.4243                                     
REMARK   3      L33:   1.6766 L12:   0.2873                                     
REMARK   3      L13:   1.1274 L23:   1.0812                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0276 S12:  -0.1569 S13:  -0.0796                       
REMARK   3      S21:   0.7417 S22:   0.1559 S23:  -0.7484                       
REMARK   3      S31:   0.2362 S32:   0.2796 S33:  -0.1835                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   578        A   617                          
REMARK   3    ORIGIN FOR THE GROUP (A):  41.8818  42.9778 245.6066              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5072 T22:   0.5342                                     
REMARK   3      T33:   0.4616 T12:   0.0287                                     
REMARK   3      T13:  -0.0280 T23:   0.0428                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3173 L22:   3.1391                                     
REMARK   3      L33:   5.2616 L12:   1.5001                                     
REMARK   3      L13:   2.2529 L23:   2.4401                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0620 S12:  -0.3318 S13:   0.3403                       
REMARK   3      S21:   0.2441 S22:  -0.0541 S23:  -0.2701                       
REMARK   3      S31:  -0.3538 S32:   0.2398 S33:   0.1161                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   618        A   738                          
REMARK   3    ORIGIN FOR THE GROUP (A):  18.2320  33.3280 210.4389              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4190 T22:   0.4136                                     
REMARK   3      T33:   0.4345 T12:  -0.0017                                     
REMARK   3      T13:  -0.0120 T23:   0.0190                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6646 L22:   0.6353                                     
REMARK   3      L33:   1.3509 L12:  -0.3718                                     
REMARK   3      L13:  -0.5066 L23:   0.7700                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0198 S12:   0.0062 S13:   0.0342                       
REMARK   3      S21:  -0.0183 S22:  -0.0074 S23:  -0.0346                       
REMARK   3      S31:  -0.0767 S32:   0.0206 S33:  -0.0124                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   739        A   799                          
REMARK   3    ORIGIN FOR THE GROUP (A):  19.7503  18.8724 196.4630              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4504 T22:   0.4603                                     
REMARK   3      T33:   0.4736 T12:   0.0058                                     
REMARK   3      T13:   0.0219 T23:   0.0296                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3414 L22:   0.5838                                     
REMARK   3      L33:   2.7168 L12:   0.1035                                     
REMARK   3      L13:   0.3357 L23:   1.1424                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0655 S12:   0.0403 S13:   0.0710                       
REMARK   3      S21:  -0.0306 S22:   0.0084 S23:  -0.0449                       
REMARK   3      S31:  -0.1198 S32:   0.1505 S33:   0.0571                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   800        A   873                          
REMARK   3    ORIGIN FOR THE GROUP (A):  16.1456  10.1941 176.2515              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4622 T22:   0.4532                                     
REMARK   3      T33:   0.4735 T12:   0.0106                                     
REMARK   3      T13:   0.0263 T23:  -0.0094                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1139 L22:   0.3365                                     
REMARK   3      L33:   2.1708 L12:   0.0732                                     
REMARK   3      L13:  -0.3182 L23:   0.0203                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0311 S12:   0.0288 S13:   0.0067                       
REMARK   3      S21:   0.0097 S22:   0.0098 S23:   0.0653                       
REMARK   3      S31:   0.0183 S32:  -0.1548 S33:   0.0213                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   874        A   878                          
REMARK   3    ORIGIN FOR THE GROUP (A):   3.0168  18.6834 168.9379              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1541 T22:   1.2314                                     
REMARK   3      T33:   0.5391 T12:   0.0904                                     
REMARK   3      T13:   0.0790 T23:  -0.3491                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  32.4065 L22:   5.8445                                     
REMARK   3      L33:  38.7345 L12:  -5.4632                                     
REMARK   3      L13: -35.1905 L23:   7.4029                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.0387 S12:   1.4793 S13:  -0.3831                       
REMARK   3      S21:  -0.0521 S22:  -1.3729 S23:   0.3963                       
REMARK   3      S31:  -1.1272 S32:  -1.7466 S33:   0.3342                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   879        A   921                          
REMARK   3    ORIGIN FOR THE GROUP (A):  20.1099  18.4140 176.1732              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4406 T22:   0.4925                                     
REMARK   3      T33:   0.4997 T12:   0.0133                                     
REMARK   3      T13:   0.0201 T23:   0.0165                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4477 L22:   2.8625                                     
REMARK   3      L33:   3.6798 L12:   0.5033                                     
REMARK   3      L13:   0.3643 L23:   1.7807                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0115 S12:  -0.0374 S13:   0.0897                       
REMARK   3      S21:   0.0298 S22:  -0.1060 S23:   0.3926                       
REMARK   3      S31:  -0.2384 S32:  -0.3633 S33:   0.1176                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   922        A   981                          
REMARK   3    ORIGIN FOR THE GROUP (A):   7.0110  -0.5446 142.5086              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4927 T22:   0.5752                                     
REMARK   3      T33:   0.5249 T12:  -0.0207                                     
REMARK   3      T13:   0.0092 T23:  -0.0384                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4978 L22:   0.4233                                     
REMARK   3      L33:   2.0423 L12:  -0.0427                                     
REMARK   3      L13:  -0.2205 L23:  -0.3677                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0473 S12:   0.1221 S13:  -0.0188                       
REMARK   3      S21:  -0.0644 S22:  -0.0104 S23:   0.1872                       
REMARK   3      S31:   0.0016 S32:  -0.5265 S33:   0.0577                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   982        A  1094                          
REMARK   3    ORIGIN FOR THE GROUP (A):  31.5350  -5.8186 171.8597              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5125 T22:   0.4356                                     
REMARK   3      T33:   0.4558 T12:   0.0021                                     
REMARK   3      T13:   0.0548 T23:  -0.0141                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6684 L22:   0.9609                                     
REMARK   3      L33:   1.8406 L12:  -0.0352                                     
REMARK   3      L13:   0.4083 L23:  -0.3730                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0862 S12:   0.0049 S13:  -0.1741                       
REMARK   3      S21:   0.0703 S22:  -0.0654 S23:  -0.1962                       
REMARK   3      S31:   0.3226 S32:   0.2515 S33:  -0.0208                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A  1095        A  1222                          
REMARK   3    ORIGIN FOR THE GROUP (A):  13.6518   0.8359 139.8172              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4009 T22:   0.4507                                     
REMARK   3      T33:   0.4252 T12:  -0.0127                                     
REMARK   3      T13:  -0.0015 T23:  -0.0079                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8184 L22:   0.6956                                     
REMARK   3      L33:   1.2910 L12:  -0.2632                                     
REMARK   3      L13:   0.0373 L23:   0.4522                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0064 S12:   0.0959 S13:   0.0357                       
REMARK   3      S21:  -0.1192 S22:  -0.0251 S23:   0.0617                       
REMARK   3      S31:  -0.0339 S32:  -0.1177 S33:   0.0315                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A  1223        A  1247                          
REMARK   3    ORIGIN FOR THE GROUP (A):  17.2326 -25.7441 136.7234              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5304 T22:   0.5806                                     
REMARK   3      T33:   0.5846 T12:  -0.0781                                     
REMARK   3      T13:   0.0642 T23:   0.0119                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9778 L22:  11.0161                                     
REMARK   3      L33:  12.4168 L12:   3.8043                                     
REMARK   3      L13:   4.4359 L23:  10.8402                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2773 S12:  -0.0455 S13:  -0.4383                       
REMARK   3      S21:   0.6370 S22:  -0.0005 S23:  -0.0710                       
REMARK   3      S31:   1.0730 S32:  -0.3326 S33:  -0.2768                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B     7        B    21                          
REMARK   3    ORIGIN FOR THE GROUP (A):  47.3266 -39.7244 110.2064              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5487 T22:   0.5045                                     
REMARK   3      T33:   0.4985 T12:   0.0671                                     
REMARK   3      T13:  -0.0043 T23:  -0.0050                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.6742 L22:   8.8236                                     
REMARK   3      L33:   2.9182 L12:   0.7870                                     
REMARK   3      L13:  -0.6470 L23:  -2.6348                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0076 S12:   0.8035 S13:  -1.0559                       
REMARK   3      S21:  -0.7507 S22:   0.0751 S23:   0.0304                       
REMARK   3      S31:   0.5465 S32:  -0.1312 S33:  -0.0674                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B    22        B    61                          
REMARK   3    ORIGIN FOR THE GROUP (A):  70.7860 -16.4851 120.3789              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4926 T22:   0.6561                                     
REMARK   3      T33:   0.5484 T12:   0.0037                                     
REMARK   3      T13:   0.0446 T23:  -0.0639                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.3008 L22:   1.3767                                     
REMARK   3      L33:   2.0826 L12:   0.0220                                     
REMARK   3      L13:  -0.8553 L23:   0.0645                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1732 S12:  -0.2833 S13:   0.5793                       
REMARK   3      S21:   0.1521 S22:   0.0709 S23:  -0.5129                       
REMARK   3      S31:  -0.2580 S32:   0.7615 S33:  -0.2441                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B    62        B   103                          
REMARK   3    ORIGIN FOR THE GROUP (A):  77.9874 -23.9562 116.6649              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4436 T22:   0.6689                                     
REMARK   3      T33:   0.6324 T12:   0.1178                                     
REMARK   3      T13:   0.1130 T23:  -0.0877                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.7014 L22:   1.3092                                     
REMARK   3      L33:   3.3747 L12:  -0.1949                                     
REMARK   3      L13:   2.2584 L23:   0.3753                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0877 S12:   0.1975 S13:  -0.0203                       
REMARK   3      S21:  -0.0719 S22:   0.0884 S23:  -0.7647                       
REMARK   3      S31:   0.0359 S32:   0.9844 S33:  -0.1761                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   104        B   150                          
REMARK   3    ORIGIN FOR THE GROUP (A):  48.7492 -28.2539 107.5174              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4923 T22:   0.4468                                     
REMARK   3      T33:   0.4236 T12:   0.0087                                     
REMARK   3      T13:   0.0293 T23:  -0.0062                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9472 L22:   0.8222                                     
REMARK   3      L33:   0.7222 L12:   0.3129                                     
REMARK   3      L13:   0.2905 L23:   0.2004                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0078 S12:   0.1551 S13:  -0.1656                       
REMARK   3      S21:  -0.1067 S22:   0.0286 S23:  -0.0699                       
REMARK   3      S31:   0.0943 S32:   0.0948 S33:  -0.0208                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   151        B   186                          
REMARK   3    ORIGIN FOR THE GROUP (A):  74.8546 -25.6326 111.7079              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4375 T22:   0.5821                                     
REMARK   3      T33:   0.4972 T12:   0.0510                                     
REMARK   3      T13:   0.0904 T23:  -0.0683                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9737 L22:   4.2201                                     
REMARK   3      L33:   5.7875 L12:  -1.8417                                     
REMARK   3      L13:   3.5946 L23:  -1.2353                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1173 S12:   0.2439 S13:  -0.2332                       
REMARK   3      S21:   0.0378 S22:   0.0239 S23:  -0.5719                       
REMARK   3      S31:   0.4690 S32:   0.8306 S33:  -0.1413                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   187        B   313                          
REMARK   3    ORIGIN FOR THE GROUP (A):  39.5909 -15.5789 107.7619              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4778 T22:   0.4331                                     
REMARK   3      T33:   0.4122 T12:  -0.0057                                     
REMARK   3      T13:   0.0057 T23:   0.0055                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1003 L22:   0.7719                                     
REMARK   3      L33:   0.7194 L12:  -0.1558                                     
REMARK   3      L13:  -0.0458 L23:   0.2059                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0384 S12:   0.1624 S13:  -0.0115                       
REMARK   3      S21:  -0.1297 S22:  -0.0310 S23:  -0.0437                       
REMARK   3      S31:  -0.0293 S32:  -0.0086 S33:  -0.0073                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   314        B   320                          
REMARK   3    ORIGIN FOR THE GROUP (A):  50.4916  -9.8770  89.7673              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3935 T22:   0.7611                                     
REMARK   3      T33:   0.4911 T12:  -0.3570                                     
REMARK   3      T13:   0.4045 T23:  -0.0838                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8100 L22:  23.7075                                     
REMARK   3      L33:  19.0355 L12:  13.5308                                     
REMARK   3      L13:  12.1797 L23:  21.2003                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2229 S12:   0.3051 S13:  -0.3979                       
REMARK   3      S21:  -0.9766 S22:   0.8613 S23:  -0.8548                       
REMARK   3      S31:  -0.6118 S32:   0.5665 S33:  -0.6384                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   321        B   389                          
REMARK   3    ORIGIN FOR THE GROUP (A):  33.9182  -8.5702 119.3767              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4391 T22:   0.4301                                     
REMARK   3      T33:   0.4199 T12:  -0.0032                                     
REMARK   3      T13:  -0.0040 T23:  -0.0108                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1030 L22:   0.8492                                     
REMARK   3      L33:   0.6753 L12:   0.1748                                     
REMARK   3      L13:  -0.3557 L23:  -0.1354                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0200 S12:   0.0617 S13:   0.0807                       
REMARK   3      S21:  -0.0364 S22:   0.0098 S23:   0.0026                       
REMARK   3      S31:  -0.0525 S32:  -0.0395 S33:  -0.0298                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   390        B   449                          
REMARK   3    ORIGIN FOR THE GROUP (A):  30.5214 -19.9117 125.5859              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4658 T22:   0.5181                                     
REMARK   3      T33:   0.4566 T12:   0.0363                                     
REMARK   3      T13:   0.0112 T23:   0.0162                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0963 L22:   1.6058                                     
REMARK   3      L33:   1.3112 L12:   0.2431                                     
REMARK   3      L13:   0.0833 L23:   0.4878                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0064 S12:   0.0420 S13:  -0.0245                       
REMARK   3      S21:  -0.0009 S22:  -0.0023 S23:   0.0954                       
REMARK   3      S31:   0.0955 S32:  -0.0669 S33:   0.0087                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   450        B   528                          
REMARK   3    ORIGIN FOR THE GROUP (A):  31.1063 -39.9198 117.1737              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5092 T22:   0.4128                                     
REMARK   3      T33:   0.5246 T12:  -0.0342                                     
REMARK   3      T13:   0.0090 T23:  -0.0008                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1657 L22:   1.8991                                     
REMARK   3      L33:   2.8228 L12:  -0.1909                                     
REMARK   3      L13:  -0.3568 L23:  -0.0757                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0501 S12:   0.0876 S13:  -0.3845                       
REMARK   3      S21:   0.0185 S22:  -0.0096 S23:   0.0820                       
REMARK   3      S31:   0.4812 S32:  -0.1207 S33:   0.0597                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   529        B   538                          
REMARK   3    ORIGIN FOR THE GROUP (A):  37.9107 -23.3720 127.5591              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4969 T22:   0.4424                                     
REMARK   3      T33:   0.4419 T12:   0.0186                                     
REMARK   3      T13:   0.0064 T23:  -0.0195                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  10.5186 L22:   8.5800                                     
REMARK   3      L33:   7.9134 L12:   5.1878                                     
REMARK   3      L13:  -1.8808 L23:  -6.5392                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0580 S12:   0.1957 S13:  -0.7054                       
REMARK   3      S21:  -0.2561 S22:  -0.0222 S23:  -0.2251                       
REMARK   3      S31:   0.5654 S32:   0.2068 S33:   0.0802                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   539        B   638                          
REMARK   3    ORIGIN FOR THE GROUP (A):  43.8081  -2.1528 142.8676              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4163 T22:   0.4459                                     
REMARK   3      T33:   0.4410 T12:  -0.0253                                     
REMARK   3      T13:   0.0177 T23:   0.0144                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5209 L22:   1.2306                                     
REMARK   3      L33:   2.3219 L12:  -0.5021                                     
REMARK   3      L13:  -0.7584 L23:   1.4745                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0615 S12:  -0.0161 S13:   0.0663                       
REMARK   3      S21:  -0.1328 S22:   0.0464 S23:  -0.1365                       
REMARK   3      S31:  -0.1302 S32:   0.0584 S33:  -0.1078                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   639        B   661                          
REMARK   3    ORIGIN FOR THE GROUP (A):  23.9385  33.1594 166.9092              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8091 T22:   1.0434                                     
REMARK   3      T33:   1.0154 T12:   0.1520                                     
REMARK   3      T13:  -0.3884 T23:  -0.0037                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9461 L22:   4.8560                                     
REMARK   3      L33:   4.4836 L12:   3.7754                                     
REMARK   3      L13:  -3.6292 L23:  -4.6607                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1306 S12:   0.0355 S13:   0.3428                       
REMARK   3      S21:   0.1779 S22:   0.1959 S23:   0.4251                       
REMARK   3      S31:  -0.2203 S32:  -0.1096 S33:  -0.3265                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   662        B   731                          
REMARK   3    ORIGIN FOR THE GROUP (A):  39.1094   2.0912 152.4579              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4168 T22:   0.4506                                     
REMARK   3      T33:   0.4179 T12:  -0.0180                                     
REMARK   3      T13:   0.0340 T23:   0.0162                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2997 L22:   1.0715                                     
REMARK   3      L33:   1.1460 L12:  -0.0544                                     
REMARK   3      L13:  -0.1343 L23:   0.5123                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0044 S12:  -0.0056 S13:   0.0320                       
REMARK   3      S21:   0.0405 S22:   0.0276 S23:  -0.0015                       
REMARK   3      S31:  -0.0365 S32:   0.0378 S33:  -0.0232                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   732        B   769                          
REMARK   3    ORIGIN FOR THE GROUP (A):  37.4278   3.4389 164.4582              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4589 T22:   0.4893                                     
REMARK   3      T33:   0.4369 T12:  -0.0031                                     
REMARK   3      T13:   0.0487 T23:   0.0162                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9496 L22:   3.4106                                     
REMARK   3      L33:   3.7182 L12:   1.3818                                     
REMARK   3      L13:   1.9818 L23:   2.9553                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0043 S12:   0.0560 S13:  -0.1438                       
REMARK   3      S21:   0.0401 S22:   0.0061 S23:   0.0512                       
REMARK   3      S31:   0.1812 S32:   0.0113 S33:  -0.0105                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   770        B   853                          
REMARK   3    ORIGIN FOR THE GROUP (A):  48.5058  14.9139 180.5021              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4348 T22:   0.5004                                     
REMARK   3      T33:   0.4147 T12:   0.0062                                     
REMARK   3      T13:   0.0092 T23:   0.0198                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2546 L22:   1.9350                                     
REMARK   3      L33:   1.5960 L12:   0.2802                                     
REMARK   3      L13:  -0.0056 L23:   0.2903                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0036 S12:   0.0147 S13:   0.0380                       
REMARK   3      S21:   0.0032 S22:   0.0234 S23:  -0.1253                       
REMARK   3      S31:  -0.0153 S32:   0.1617 S33:  -0.0270                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   854        B   929                          
REMARK   3    ORIGIN FOR THE GROUP (A):  57.7159  15.9758 202.3668              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4725 T22:   0.5784                                     
REMARK   3      T33:   0.4365 T12:   0.0330                                     
REMARK   3      T13:  -0.0039 T23:   0.0138                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0104 L22:   1.2161                                     
REMARK   3      L33:   2.5559 L12:   0.6386                                     
REMARK   3      L13:   1.7571 L23:   1.0950                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0166 S12:  -0.2494 S13:   0.1096                       
REMARK   3      S21:   0.2539 S22:   0.0240 S23:  -0.3115                       
REMARK   3      S31:   0.1020 S32:   0.2640 S33:  -0.0406                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   930        B   960                          
REMARK   3    ORIGIN FOR THE GROUP (A):  38.1793  -4.2977 194.2186              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6493 T22:   0.4152                                     
REMARK   3      T33:   0.4946 T12:  -0.0047                                     
REMARK   3      T13:   0.0243 T23:  -0.0061                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1099 L22:   4.8761                                     
REMARK   3      L33:   5.7541 L12:   1.4967                                     
REMARK   3      L13:   0.5467 L23:   0.9149                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0142 S12:  -0.7560 S13:  -0.1573                       
REMARK   3      S21:   0.8387 S22:  -0.0893 S23:  -0.5071                       
REMARK   3      S31:   0.0498 S32:   0.2217 S33:   0.1035                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   961        B  1017                          
REMARK   3    ORIGIN FOR THE GROUP (A):  55.0460  11.7128 202.9591              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4912 T22:   0.5566                                     
REMARK   3      T33:   0.4398 T12:   0.0396                                     
REMARK   3      T13:  -0.0170 T23:   0.0394                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2078 L22:   1.5343                                     
REMARK   3      L33:   1.9444 L12:   0.9045                                     
REMARK   3      L13:   0.5590 L23:   1.5782                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1091 S12:  -0.1202 S13:  -0.2381                       
REMARK   3      S21:   0.2458 S22:   0.0780 S23:  -0.3263                       
REMARK   3      S31:   0.4019 S32:   0.3392 S33:  -0.1871                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B  1018        B  1121                          
REMARK   3    ORIGIN FOR THE GROUP (A):  46.7262  21.9271 208.4993              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4401 T22:   0.5060                                     
REMARK   3      T33:   0.4463 T12:  -0.0143                                     
REMARK   3      T13:   0.0010 T23:   0.0157                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7864 L22:   1.1438                                     
REMARK   3      L33:   2.4402 L12:  -0.8581                                     
REMARK   3      L13:  -0.0358 L23:   0.4046                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0312 S12:  -0.0919 S13:   0.0056                       
REMARK   3      S21:   0.1338 S22:   0.0410 S23:  -0.0608                       
REMARK   3      S31:   0.0246 S32:   0.1796 S33:  -0.0097                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    21        D    27                          
REMARK   3    ORIGIN FOR THE GROUP (A):  29.5731  29.7919 261.6386              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9895 T22:   0.7493                                     
REMARK   3      T33:   0.4909 T12:   0.2949                                     
REMARK   3      T13:   0.2082 T23:   0.1796                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2727 L22:   3.2011                                     
REMARK   3      L33:   0.7722 L12:   0.8459                                     
REMARK   3      L13:   0.4460 L23:   1.5391                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0630 S12:  -0.1508 S13:   0.1305                       
REMARK   3      S21:   0.1337 S22:  -0.1158 S23:   0.2399                       
REMARK   3      S31:   0.0111 S32:  -0.1520 S33:   0.1787                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    28        D    39                          
REMARK   3    ORIGIN FOR THE GROUP (A):  26.7667  19.3025 253.3140              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5380 T22:   0.5116                                     
REMARK   3      T33:   0.3937 T12:   0.0168                                     
REMARK   3      T13:   0.0428 T23:   0.0651                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7531 L22:   4.5186                                     
REMARK   3      L33:   6.8499 L12:   3.5727                                     
REMARK   3      L13:   4.4603 L23:   2.9366                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1583 S12:  -0.1412 S13:   0.1626                       
REMARK   3      S21:  -0.0495 S22:  -0.0912 S23:   0.1201                       
REMARK   3      S31:  -0.3850 S32:  -0.1810 S33:   0.2496                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    40        D    49                          
REMARK   3    ORIGIN FOR THE GROUP (A):  21.8985  12.8403 239.0589              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4865 T22:   0.4848                                     
REMARK   3      T33:   0.6111 T12:   0.0151                                     
REMARK   3      T13:   0.0286 T23:   0.0519                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0285 L22:   3.9662                                     
REMARK   3      L33:  23.3685 L12:  -1.6231                                     
REMARK   3      L13:   5.4491 L23:   5.0818                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0496 S12:   0.1421 S13:   0.1557                       
REMARK   3      S21:  -0.1873 S22:  -0.2701 S23:  -0.0063                       
REMARK   3      S31:  -0.5151 S32:  -0.2126 S33:   0.3197                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    50        D    59                          
REMARK   3    ORIGIN FOR THE GROUP (A):  18.5415   7.0035 226.3968              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5111 T22:   0.4517                                     
REMARK   3      T33:   0.4234 T12:   0.0200                                     
REMARK   3      T13:   0.0595 T23:   0.0120                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.2634 L22:   7.8461                                     
REMARK   3      L33:  14.2426 L12:   3.4448                                     
REMARK   3      L13:   6.2573 L23:   3.8004                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1548 S12:  -0.0307 S13:   0.4687                       
REMARK   3      S21:   0.0430 S22:  -0.1330 S23:   0.3524                       
REMARK   3      S31:  -0.4473 S32:  -0.6177 S33:   0.2878                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    60        D    70                          
REMARK   3    ORIGIN FOR THE GROUP (A):  15.2378  -2.5204 214.4242              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5702 T22:   0.4932                                     
REMARK   3      T33:   0.4362 T12:  -0.0175                                     
REMARK   3      T13:   0.0917 T23:   0.0552                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.5261 L22:   7.3266                                     
REMARK   3      L33:   8.8317 L12:  -0.1797                                     
REMARK   3      L13:   2.0289 L23:   3.6326                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0043 S12:  -0.3741 S13:  -0.2776                       
REMARK   3      S21:   0.4468 S22:  -0.2087 S23:   0.2336                       
REMARK   3      S31:   0.4435 S32:  -0.4551 S33:   0.2131                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    71        D    75                          
REMARK   3    ORIGIN FOR THE GROUP (A):  13.6080  -9.8188 205.2128              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7415 T22:   0.5912                                     
REMARK   3      T33:   0.5159 T12:  -0.0005                                     
REMARK   3      T13:   0.2148 T23:   0.1292                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8585 L22:  31.9097                                     
REMARK   3      L33:  16.8933 L12:  13.8031                                     
REMARK   3      L13:   1.8849 L23:  -7.9068                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2769 S12:  -0.4991 S13:   0.7429                       
REMARK   3      S21:   0.4722 S22:  -0.4883 S23:   1.3069                       
REMARK   3      S31:   0.2164 S32:  -0.7315 S33:   0.2113                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    76        D    86                          
REMARK   3    ORIGIN FOR THE GROUP (A):  15.1362 -15.7260 192.0195              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9159 T22:   0.3408                                     
REMARK   3      T33:   0.4033 T12:  -0.1049                                     
REMARK   3      T13:   0.1294 T23:   0.0189                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8817 L22:   5.9322                                     
REMARK   3      L33:  14.1399 L12:  -0.2345                                     
REMARK   3      L13:   3.7541 L23:   1.4516                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2389 S12:   0.1747 S13:  -0.7206                       
REMARK   3      S21:  -0.0350 S22:   0.1575 S23:   0.1653                       
REMARK   3      S31:   0.7061 S32:  -0.3584 S33:  -0.3964                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    87        D    91                          
REMARK   3    ORIGIN FOR THE GROUP (A):   8.1060 -12.1192 182.2320              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7676 T22:   5.0708                                     
REMARK   3      T33:   0.9025 T12:   1.3284                                     
REMARK   3      T13:  -0.0033 T23:   0.7071                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.6374 L22: 239.4169                                     
REMARK   3      L33:   5.3489 L12:  -8.7650                                     
REMARK   3      L13:   5.7409 L23:   1.6620                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0788 S12:  -5.2312 S13:  -1.6047                       
REMARK   3      S21:  -9.2113 S22:   2.1960 S23:   9.9822                       
REMARK   3      S31:  -1.2474 S32:  -4.6536 S33:  -1.1172                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    92        D   100                          
REMARK   3    ORIGIN FOR THE GROUP (A):   1.0099  -1.2126 184.6205              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6113 T22:   0.6819                                     
REMARK   3      T33:   0.5894 T12:  -0.4101                                     
REMARK   3      T13:  -0.0140 T23:  -0.0989                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2762 L22:  11.6063                                     
REMARK   3      L33:  23.3569 L12:  -3.5977                                     
REMARK   3      L13:   3.2010 L23:   7.5796                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3638 S12:   0.2452 S13:  -0.6827                       
REMARK   3      S21:  -0.7214 S22:  -0.9883 S23:   1.2897                       
REMARK   3      S31:   0.8083 S32:  -1.1619 S33:   0.6246                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   101        D   113                          
REMARK   3    ORIGIN FOR THE GROUP (A):   8.9559  14.4988 206.1358              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5003 T22:   0.5211                                     
REMARK   3      T33:   0.4363 T12:  -0.0196                                     
REMARK   3      T13:   0.0460 T23:  -0.0128                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0865 L22:   8.3670                                     
REMARK   3      L33:   9.2244 L12:   0.5987                                     
REMARK   3      L13:   0.5392 L23:   8.4333                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1474 S12:   0.0173 S13:   0.0201                       
REMARK   3      S21:  -0.1535 S22:  -0.3463 S23:   0.5507                       
REMARK   3      S31:  -0.1378 S32:  -0.4863 S33:   0.4937                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   114        D   131                          
REMARK   3    ORIGIN FOR THE GROUP (A):   7.7784  22.2674 231.0358              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5327 T22:   0.5145                                     
REMARK   3      T33:   0.5088 T12:  -0.0282                                     
REMARK   3      T13:   0.0619 T23:   0.0641                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5308 L22:   6.8596                                     
REMARK   3      L33:   9.2779 L12:  -3.5621                                     
REMARK   3      L13:  -3.1408 L23:   2.9539                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3740 S12:  -0.2415 S13:  -0.3475                       
REMARK   3      S21:   0.3603 S22:   0.1272 S23:   0.0678                       
REMARK   3      S31:   0.7083 S32:   0.3324 S33:   0.2468                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   132        D   145                          
REMARK   3    ORIGIN FOR THE GROUP (A): -13.3686  34.9192 227.8537              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4628 T22:   0.8439                                     
REMARK   3      T33:   0.5330 T12:  -0.0983                                     
REMARK   3      T13:  -0.0475 T23:   0.0342                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8698 L22:   2.4346                                     
REMARK   3      L33:   2.9067 L12:  -2.0785                                     
REMARK   3      L13:  -1.0383 L23:   2.3622                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4400 S12:   0.6626 S13:  -0.2657                       
REMARK   3      S21:   0.1141 S22:  -0.2452 S23:   0.6391                       
REMARK   3      S31:  -0.0028 S32:  -0.3526 S33:   0.6852                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   146        D   160                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.4142  34.5975 220.2983              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4541 T22:   0.5440                                     
REMARK   3      T33:   0.5366 T12:   0.0073                                     
REMARK   3      T13:   0.0057 T23:   0.0173                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5957 L22:   1.7722                                     
REMARK   3      L33:  12.4501 L12:  -1.4552                                     
REMARK   3      L13:  -4.1609 L23:   3.0449                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0072 S12:   0.1957 S13:  -0.2408                       
REMARK   3      S21:   0.0974 S22:  -0.0304 S23:   0.4174                       
REMARK   3      S31:   0.1657 S32:  -0.7565 S33:   0.0376                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   161        D   176                          
REMARK   3    ORIGIN FOR THE GROUP (A):   2.4304  38.4730 198.6456              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4993 T22:   0.7177                                     
REMARK   3      T33:   0.4221 T12:   0.1318                                     
REMARK   3      T13:  -0.0866 T23:   0.1206                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1358 L22:   9.3106                                     
REMARK   3      L33:  20.3104 L12:   1.1830                                     
REMARK   3      L13:  -0.7560 L23:  -8.9760                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1822 S12:   0.9406 S13:   0.5977                       
REMARK   3      S21:  -0.9185 S22:  -0.2053 S23:   0.2262                       
REMARK   3      S31:  -0.3721 S32:  -0.3987 S33:   0.0231                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   177        D   183                          
REMARK   3    ORIGIN FOR THE GROUP (A):   2.9207  45.4407 182.6988              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6409 T22:   1.0740                                     
REMARK   3      T33:   0.3078 T12:   0.0479                                     
REMARK   3      T13:  -0.1654 T23:   0.1531                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7835 L22:  22.7067                                     
REMARK   3      L33:   0.1486 L12:  -4.2098                                     
REMARK   3      L13:   0.3356 L23:  -1.8119                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2339 S12:   0.0001 S13:   0.1003                       
REMARK   3      S21:   1.1628 S22:   0.2251 S23:  -0.4057                       
REMARK   3      S31:  -0.0719 S32:   0.0209 S33:   0.0088                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   184        D   221                          
REMARK   3    ORIGIN FOR THE GROUP (A):   0.3955   8.5019 167.7376              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4698 T22:   0.8550                                     
REMARK   3      T33:   0.4231 T12:  -0.1450                                     
REMARK   3      T13:   0.0988 T23:  -0.4274                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0072 L22:   0.2472                                     
REMARK   3      L33:   0.8992 L12:  -0.4685                                     
REMARK   3      L13:   0.8819 L23:  -0.4703                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5032 S12:   0.1397 S13:  -0.2127                       
REMARK   3      S21:  -0.0708 S22:  -0.1732 S23:   0.1565                       
REMARK   3      S31:   0.0895 S32:   0.3077 S33:  -0.3300                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   222        D   228                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.3754   3.8810 173.9898              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7911 T22:   1.8216                                     
REMARK   3      T33:   0.8603 T12:  -0.9571                                     
REMARK   3      T13:  -0.1334 T23:   0.3203                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.4608 L22:  20.9578                                     
REMARK   3      L33:  12.7835 L12: -12.7813                                     
REMARK   3      L13:  -9.8397 L23:  16.2888                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0969 S12:   0.7935 S13:  -0.1019                       
REMARK   3      S21:  -0.1496 S22:  -0.9654 S23:   1.2628                       
REMARK   3      S31:   0.1233 S32:  -1.1411 S33:   1.0623                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   229        D   234                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.8842  10.8916 181.1717              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2500 T22:   1.1529                                     
REMARK   3      T33:   0.8332 T12:  -0.0684                                     
REMARK   3      T13:   0.2693 T23:  -0.5776                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.5717 L22:  94.6682                                     
REMARK   3      L33:   8.7741 L12:  14.4202                                     
REMARK   3      L13:  -0.9471 L23:  13.5153                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0974 S12:   0.2799 S13:   0.5276                       
REMARK   3      S21:   0.7262 S22:  -0.7218 S23:   2.9203                       
REMARK   3      S31:   0.3449 S32:  -1.3430 S33:   0.6244                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   235        D   250                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.5289  17.9381 194.6764              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6287 T22:   0.6292                                     
REMARK   3      T33:   0.5300 T12:  -0.3009                                     
REMARK   3      T13:   0.1642 T23:  -0.3241                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1487 L22:  16.3836                                     
REMARK   3      L33:   7.1512 L12:   6.3395                                     
REMARK   3      L13:   6.9575 L23:   9.1316                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1686 S12:   0.7381 S13:  -0.4352                       
REMARK   3      S21:  -0.4161 S22:  -0.0979 S23:   0.5385                       
REMARK   3      S31:   0.0101 S32:   0.3841 S33:  -0.0707                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   251        D   264                          
REMARK   3    ORIGIN FOR THE GROUP (A):   6.9930  30.5942 196.6900              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4523 T22:   0.8652                                     
REMARK   3      T33:   0.7190 T12:   0.0200                                     
REMARK   3      T13:  -0.0671 T23:   0.2614                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7067 L22:  10.1837                                     
REMARK   3      L33:  16.2589 L12:  -3.0839                                     
REMARK   3      L13:  -5.3851 L23:  -2.7978                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4412 S12:   0.9156 S13:   0.6566                       
REMARK   3      S21:  -1.2814 S22:  -0.4497 S23:  -0.6774                       
REMARK   3      S31:   0.0917 S32:  -1.0680 S33:   0.0085                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    10        E    13                          
REMARK   3    ORIGIN FOR THE GROUP (A):  42.3341  25.7331 263.2652              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4196 T22:   1.0570                                     
REMARK   3      T33:   0.6920 T12:   0.1326                                     
REMARK   3      T13:   0.0174 T23:   0.0211                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5244 L22:   5.7783                                     
REMARK   3      L33:   2.9625 L12:  -7.0107                                     
REMARK   3      L13:   5.0239 L23:  -4.1303                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6129 S12:   0.2718 S13:   1.4679                       
REMARK   3      S21:   0.5854 S22:  -0.2452 S23:  -1.1454                       
REMARK   3      S31:  -0.3160 S32:   0.1663 S33:   0.8582                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    14        E    18                          
REMARK   3    ORIGIN FOR THE GROUP (A):  40.0994  23.2667 257.2617              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5766 T22:   0.6175                                     
REMARK   3      T33:   0.5184 T12:   0.1137                                     
REMARK   3      T13:  -0.0531 T23:   0.0778                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  26.4095 L22:   7.4471                                     
REMARK   3      L33:   8.9771 L12:  11.9546                                     
REMARK   3      L13:  -2.0334 L23:   3.2908                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4910 S12:  -1.1277 S13:  -0.6638                       
REMARK   3      S21:   0.7383 S22:  -0.2883 S23:  -0.5151                       
REMARK   3      S31:   0.9215 S32:   0.5102 S33:  -0.2026                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    19        E    22                          
REMARK   3    ORIGIN FOR THE GROUP (A):  37.8234  20.2845 251.6960              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5095 T22:   0.5339                                     
REMARK   3      T33:   0.4797 T12:   0.0107                                     
REMARK   3      T13:  -0.0024 T23:   0.0817                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.2766 L22:   9.7186                                     
REMARK   3      L33:  13.9170 L12:  -7.9353                                     
REMARK   3      L13:  -4.9676 L23:   9.9904                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2343 S12:  -0.1144 S13:   0.3508                       
REMARK   3      S21:  -0.0646 S22:   0.3244 S23:  -0.5175                       
REMARK   3      S31:   0.1255 S32:   0.4745 S33:  -0.5587                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    23        E    28                          
REMARK   3    ORIGIN FOR THE GROUP (A):  36.1115  18.0887 244.8744              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5117 T22:   0.5227                                     
REMARK   3      T33:   0.6326 T12:   0.0497                                     
REMARK   3      T13:  -0.0237 T23:  -0.0021                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  18.6329 L22:   0.6147                                     
REMARK   3      L33:  15.2948 L12:  -2.0469                                     
REMARK   3      L13:   8.4954 L23:  -3.0388                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2303 S12:  -0.1868 S13:   1.1633                       
REMARK   3      S21:   0.0503 S22:  -0.0983 S23:  -0.1094                       
REMARK   3      S31:  -0.1349 S32:   0.6367 S33:   0.3286                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    29        E    34                          
REMARK   3    ORIGIN FOR THE GROUP (A):  32.3377  16.2447 236.9822              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4866 T22:   0.5463                                     
REMARK   3      T33:   1.0129 T12:   0.0086                                     
REMARK   3      T13:   0.0950 T23:  -0.1367                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3268 L22:   7.2652                                     
REMARK   3      L33:  19.1197 L12:   3.7269                                     
REMARK   3      L13:   5.1835 L23:  -3.5294                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2228 S12:  -0.0799 S13:   0.5975                       
REMARK   3      S21:  -0.0984 S22:  -0.1405 S23:  -0.4174                       
REMARK   3      S31:  -0.6086 S32:   0.6702 S33:   0.3633                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    35        E    42                          
REMARK   3    ORIGIN FOR THE GROUP (A):  28.4671  12.4388 227.3215              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5455 T22:   0.4919                                     
REMARK   3      T33:   0.4247 T12:   0.0127                                     
REMARK   3      T13:   0.0263 T23:   0.0617                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2284 L22:   5.1567                                     
REMARK   3      L33:  14.1636 L12:   2.3878                                     
REMARK   3      L13:   2.7600 L23:   6.3024                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0467 S12:   0.1238 S13:   0.6920                       
REMARK   3      S21:  -0.0871 S22:   0.0292 S23:   0.1448                       
REMARK   3      S31:  -0.7878 S32:  -0.3424 S33:   0.0175                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    43        E    47                          
REMARK   3    ORIGIN FOR THE GROUP (A):  25.0672   9.0158 219.1122              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5225 T22:   0.4412                                     
REMARK   3      T33:   0.4579 T12:   0.0059                                     
REMARK   3      T13:   0.0361 T23:   0.0534                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  10.1365 L22:   6.2817                                     
REMARK   3      L33:  28.8429 L12:   3.7215                                     
REMARK   3      L13:  -1.8306 L23:   1.8486                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3200 S12:  -0.0623 S13:  -0.2181                       
REMARK   3      S21:   0.1279 S22:  -0.1028 S23:  -0.5233                       
REMARK   3      S31:   0.5455 S32:   0.7748 S33:   0.4228                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    48        E    54                          
REMARK   3    ORIGIN FOR THE GROUP (A):  22.3720   5.6142 210.4930              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5103 T22:   0.4507                                     
REMARK   3      T33:   0.4419 T12:   0.0166                                     
REMARK   3      T13:   0.0555 T23:   0.0403                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2393 L22:   5.7520                                     
REMARK   3      L33:  13.5829 L12:   1.6594                                     
REMARK   3      L13:   2.0010 L23:   0.8549                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0246 S12:   0.1387 S13:   0.1291                       
REMARK   3      S21:  -0.3398 S22:   0.0080 S23:  -0.4403                       
REMARK   3      S31:   0.3754 S32:   0.4193 S33:   0.0167                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    55        E    61                          
REMARK   3    ORIGIN FOR THE GROUP (A):  17.2698   1.5057 202.6529              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4901 T22:   0.4605                                     
REMARK   3      T33:   0.4303 T12:  -0.0048                                     
REMARK   3      T13:   0.0549 T23:   0.0411                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5161 L22:   8.9518                                     
REMARK   3      L33:   5.9494 L12:   0.6400                                     
REMARK   3      L13:   0.8456 L23:  -1.3063                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0393 S12:  -0.0625 S13:   0.0137                       
REMARK   3      S21:  -0.3068 S22:  -0.0749 S23:  -0.2610                       
REMARK   3      S31:   0.2709 S32:   0.1486 S33:   0.1143                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    62        E    66                          
REMARK   3    ORIGIN FOR THE GROUP (A):  13.0412  -2.3346 196.2901              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5135 T22:   0.4494                                     
REMARK   3      T33:   0.4379 T12:  -0.0017                                     
REMARK   3      T13:   0.0462 T23:   0.0143                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  15.5315 L22:  30.6447                                     
REMARK   3      L33:  13.9016 L12:   4.9639                                     
REMARK   3      L13:  10.8418 L23:   5.9255                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2687 S12:  -0.9777 S13:   0.2697                       
REMARK   3      S21:   0.7480 S22:  -0.0434 S23:   0.7204                       
REMARK   3      S31:   0.5009 S32:  -0.7886 S33:   0.3121                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    67        E    73                          
REMARK   3    ORIGIN FOR THE GROUP (A):   5.4646  -4.7659 191.7762              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3456 T22:   3.8972                                     
REMARK   3      T33:   0.7713 T12:   0.2550                                     
REMARK   3      T13:   0.0200 T23:   0.0490                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  55.0951 L22:  19.5846                                     
REMARK   3      L33:   2.9756 L12: -29.2000                                     
REMARK   3      L13: -10.3596 L23:   3.4603                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -2.0941 S12:   3.2866 S13:   0.9127                       
REMARK   3      S21:   1.5274 S22:   2.1775 S23:  -0.3118                       
REMARK   3      S31:   0.2268 S32:  -2.5634 S33:  -0.0834                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 72                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F     0        F     8                          
REMARK   3    ORIGIN FOR THE GROUP (A):  21.8578  -8.8415 223.6817              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6691 T22:   0.4457                                     
REMARK   3      T33:   0.3909 T12:  -0.0381                                     
REMARK   3      T13:   0.1079 T23:   0.0798                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1267 L22:  20.8369                                     
REMARK   3      L33:  11.7978 L12:  -7.3094                                     
REMARK   3      L13:  -0.1161 L23:  10.9878                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0613 S12:   0.4554 S13:  -0.9610                       
REMARK   3      S21:   0.9812 S22:  -0.1217 S23:   0.2987                       
REMARK   3      S31:   1.1495 S32:   0.0184 S33:   0.0604                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 73                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F     9        F    16                          
REMARK   3    ORIGIN FOR THE GROUP (A):  18.9518  -3.1246 231.6617              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5823 T22:   0.4710                                     
REMARK   3      T33:   0.3965 T12:  -0.0164                                     
REMARK   3      T13:   0.0723 T23:   0.0518                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  10.0831 L22:   7.6842                                     
REMARK   3      L33:  12.0471 L12:   2.2876                                     
REMARK   3      L13:   0.8891 L23:   2.8882                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3132 S12:   0.3930 S13:  -0.7389                       
REMARK   3      S21:   0.0851 S22:  -0.3243 S23:  -0.1448                       
REMARK   3      S31:   1.0885 S32:  -0.1181 S33:   0.0112                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 74                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    17        F    24                          
REMARK   3    ORIGIN FOR THE GROUP (A):  17.7118   5.1990 241.4053              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5478 T22:   0.5524                                     
REMARK   3      T33:   0.4237 T12:  -0.0172                                     
REMARK   3      T13:   0.0442 T23:   0.0645                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.7661 L22:  15.4225                                     
REMARK   3      L33:  12.6464 L12:   0.0318                                     
REMARK   3      L13:  -4.6731 L23:   5.9548                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0889 S12:   0.2241 S13:  -0.0389                       
REMARK   3      S21:  -0.1164 S22:  -0.2087 S23:   0.9622                       
REMARK   3      S31:   0.5585 S32:  -0.9561 S33:   0.2976                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 75                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    25        F    29                          
REMARK   3    ORIGIN FOR THE GROUP (A):  19.0884   9.0086 250.1217              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5242 T22:   0.4871                                     
REMARK   3      T33:   0.4502 T12:  -0.0310                                     
REMARK   3      T13:   0.0891 T23:   0.0258                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  10.3825 L22:  23.5441                                     
REMARK   3      L33:  29.6722 L12:  -3.0428                                     
REMARK   3      L13:  -5.6725 L23:  11.6500                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1759 S12:   0.0225 S13:  -0.2353                       
REMARK   3      S21:   0.1915 S22:  -0.2965 S23:   1.6237                       
REMARK   3      S31:   0.7719 S32:  -1.3709 S33:   0.4725                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 76                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    30        F    37                          
REMARK   3    ORIGIN FOR THE GROUP (A):  22.1742  14.5118 259.1200              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5589 T22:   0.5878                                     
REMARK   3      T33:   0.4084 T12:  -0.0048                                     
REMARK   3      T13:   0.0502 T23:   0.0304                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4546 L22:   2.0722                                     
REMARK   3      L33:  13.0839 L12:   2.8049                                     
REMARK   3      L13:   4.0360 L23:   4.5130                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1450 S12:   0.0767 S13:   0.1058                       
REMARK   3      S21:   0.0458 S22:  -0.1685 S23:   0.1006                       
REMARK   3      S31:   0.3569 S32:  -0.1610 S33:   0.3135                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 77                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    38        F    44                          
REMARK   3    ORIGIN FOR THE GROUP (A):  26.4301  15.9251 266.8419              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7304 T22:   0.7988                                     
REMARK   3      T33:   0.4629 T12:  -0.0571                                     
REMARK   3      T13:  -0.1301 T23:   0.1246                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9535 L22:   7.4090                                     
REMARK   3      L33:  10.8590 L12:  -4.8620                                     
REMARK   3      L13:  -1.2623 L23:   7.0050                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0402 S12:  -0.3641 S13:   1.1121                       
REMARK   3      S21:   0.9250 S22:   0.6796 S23:  -0.6108                       
REMARK   3      S31:   0.0572 S32:   0.8310 S33:   0.3605                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 78                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    45        F    49                          
REMARK   3    ORIGIN FOR THE GROUP (A):  31.0163  11.2809 262.2433              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5414 T22:   0.9921                                     
REMARK   3      T33:   0.5046 T12:   0.0563                                     
REMARK   3      T13:  -0.0042 T23:   0.3747                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2628 L22:  35.8143                                     
REMARK   3      L33:  28.9653 L12:  -5.8518                                     
REMARK   3      L13:   3.2554 L23:  -1.7265                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0654 S12:   0.0561 S13:   0.0653                       
REMARK   3      S21:   0.7618 S22:  -0.0212 S23:  -0.4165                       
REMARK   3      S31:   1.7696 S32:   0.6636 S33:  -0.0442                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 79                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    50        F    58                          
REMARK   3    ORIGIN FOR THE GROUP (A):  30.6106   9.4582 251.9482              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6087 T22:   0.5459                                     
REMARK   3      T33:   0.4900 T12:   0.0363                                     
REMARK   3      T13:  -0.0164 T23:   0.0964                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1225 L22:   0.1683                                     
REMARK   3      L33:  19.2094 L12:  -0.5693                                     
REMARK   3      L13:  -2.9843 L23:   1.2185                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0767 S12:  -0.0844 S13:  -0.2967                       
REMARK   3      S21:   0.0667 S22:   0.0290 S23:   0.0993                       
REMARK   3      S31:   0.6050 S32:  -0.0041 S33:   0.0477                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 80                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    59        F    72                          
REMARK   3    ORIGIN FOR THE GROUP (A):  28.6556   2.8220 235.4375              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5629 T22:   0.4526                                     
REMARK   3      T33:   0.4825 T12:   0.0404                                     
REMARK   3      T13:   0.0476 T23:   0.0557                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6670 L22:   3.2293                                     
REMARK   3      L33:  13.1478 L12:   0.2779                                     
REMARK   3      L13:   2.1097 L23:   5.2783                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1735 S12:  -0.0488 S13:  -0.0755                       
REMARK   3      S21:   0.0051 S22:  -0.0078 S23:  -0.2196                       
REMARK   3      S31:   0.5485 S32:  -0.0434 S33:  -0.1657                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 81                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    73        F    77                          
REMARK   3    ORIGIN FOR THE GROUP (A):  27.7527  -0.4089 222.1400              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5840 T22:   0.4811                                     
REMARK   3      T33:   0.3835 T12:  -0.0037                                     
REMARK   3      T13:   0.0543 T23:   0.0389                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  19.2377 L22:   5.5686                                     
REMARK   3      L33:  23.7297 L12:  -4.8325                                     
REMARK   3      L13:   2.5666 L23:   3.3116                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1101 S12:  -0.5827 S13:  -0.3746                       
REMARK   3      S21:   0.2474 S22:   0.2085 S23:  -0.3459                       
REMARK   3      S31:   0.2637 S32:   0.9611 S33:  -0.0984                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 82                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    78        F    83                          
REMARK   3    ORIGIN FOR THE GROUP (A):  25.1710  -3.2296 214.4994              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5949 T22:   0.4923                                     
REMARK   3      T33:   0.4736 T12:   0.0324                                     
REMARK   3      T13:   0.1087 T23:  -0.0149                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4156 L22:   2.9013                                     
REMARK   3      L33:   4.9112 L12:   1.3935                                     
REMARK   3      L13:  -3.0007 L23:  -0.2334                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0973 S12:   0.1029 S13:  -0.0609                       
REMARK   3      S21:   0.1249 S22:   0.0401 S23:  -0.3420                       
REMARK   3      S31:   0.3597 S32:  -0.2374 S33:   0.0573                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 83                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    84        F    89                          
REMARK   3    ORIGIN FOR THE GROUP (A):  26.2291  -5.4642 206.5815              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6157 T22:   0.4660                                     
REMARK   3      T33:   0.4312 T12:   0.0326                                     
REMARK   3      T13:   0.0639 T23:   0.0387                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  15.3346 L22:  14.7273                                     
REMARK   3      L33:  27.3589 L12:  -0.5290                                     
REMARK   3      L13:   9.2644 L23:   6.8152                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2192 S12:  -0.3305 S13:   0.1017                       
REMARK   3      S21:   0.5290 S22:  -0.2070 S23:  -0.5764                       
REMARK   3      S31:   0.4272 S32:   0.9864 S33:   0.4262                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 84                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    90        F   104                          
REMARK   3    ORIGIN FOR THE GROUP (A):  21.2755  -8.5451 190.3865              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5176 T22:   0.4193                                     
REMARK   3      T33:   0.4251 T12:  -0.0016                                     
REMARK   3      T13:   0.0513 T23:   0.0341                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6001 L22:   2.8130                                     
REMARK   3      L33:   9.7522 L12:   0.6334                                     
REMARK   3      L13:   0.6218 L23:   3.4390                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0487 S12:  -0.0245 S13:   0.0439                       
REMARK   3      S21:   0.0995 S22:   0.0658 S23:  -0.1574                       
REMARK   3      S31:   0.0182 S32:   0.2741 S33:  -0.0171                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 85                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   105        F   114                          
REMARK   3    ORIGIN FOR THE GROUP (A):  17.6742 -11.1449 172.5213              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5714 T22:   0.4537                                     
REMARK   3      T33:   0.5413 T12:  -0.0484                                     
REMARK   3      T13:   0.1088 T23:  -0.0420                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2025 L22:   0.2059                                     
REMARK   3      L33:  10.7476 L12:   0.4820                                     
REMARK   3      L13:  -0.4186 L23:  -1.0831                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2068 S12:   0.0898 S13:  -0.1285                       
REMARK   3      S21:  -0.0717 S22:   0.0442 S23:   0.0144                       
REMARK   3      S31:   0.7202 S32:  -0.5336 S33:   0.1626                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 86                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   115        F   120                          
REMARK   3    ORIGIN FOR THE GROUP (A):  33.0139 -14.6012 160.8974              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6596 T22:   0.4978                                     
REMARK   3      T33:   0.5066 T12:   0.0101                                     
REMARK   3      T13:   0.0400 T23:  -0.0614                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  42.5453 L22:   0.3064                                     
REMARK   3      L33:   8.2865 L12:  -2.7207                                     
REMARK   3      L13: -15.9565 L23:   0.4723                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0209 S12:   0.2359 S13:  -0.9995                       
REMARK   3      S21:   0.0521 S22:  -0.0523 S23:   0.1344                       
REMARK   3      S31:  -0.1652 S32:  -0.0342 S33:   0.0314                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 87                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   121        F   130                          
REMARK   3    ORIGIN FOR THE GROUP (A):  49.5491 -20.5766 151.0636              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5343 T22:   0.5503                                     
REMARK   3      T33:   0.4937 T12:   0.0311                                     
REMARK   3      T13:   0.0192 T23:   0.0277                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8937 L22:   1.9255                                     
REMARK   3      L33:   3.7681 L12:  -3.0174                                     
REMARK   3      L13:  -0.2704 L23:  -0.3069                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0898 S12:  -0.2629 S13:   0.0925                       
REMARK   3      S21:   0.0358 S22:   0.1148 S23:  -0.0955                       
REMARK   3      S31:   0.3680 S32:   0.4433 S33:  -0.0250                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 88                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   131        F   135                          
REMARK   3    ORIGIN FOR THE GROUP (A):  60.6082 -30.4034 137.8004              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6732 T22:   0.5823                                     
REMARK   3      T33:   0.4508 T12:   0.3034                                     
REMARK   3      T13:  -0.0526 T23:   0.0226                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  10.1180 L22:   5.9129                                     
REMARK   3      L33:  10.7639 L12:   7.3738                                     
REMARK   3      L13:   6.5021 L23:   6.6055                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2269 S12:  -0.2761 S13:  -1.1951                       
REMARK   3      S21:   0.6620 S22:   0.1200 S23:  -0.7875                       
REMARK   3      S31:   1.7332 S32:   0.8305 S33:  -0.3469                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 89                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   136        F   139                          
REMARK   3    ORIGIN FOR THE GROUP (A):  63.5447 -33.7190 124.8978              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6024 T22:   0.8245                                     
REMARK   3      T33:   0.5739 T12:   0.0177                                     
REMARK   3      T13:  -0.0083 T23:   0.0902                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  13.3806 L22:   3.4574                                     
REMARK   3      L33:  19.3271 L12:   3.1832                                     
REMARK   3      L13:  -1.4718 L23:   6.5713                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1083 S12:   0.1186 S13:  -0.1428                       
REMARK   3      S21:   0.5129 S22:   0.0974 S23:  -0.1558                       
REMARK   3      S31:   1.2854 S32:  -0.8929 S33:  -0.2058                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 90                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   140        F   149                          
REMARK   3    ORIGIN FOR THE GROUP (A):  51.1723 -41.9695 118.9660              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5636 T22:   0.4107                                     
REMARK   3      T33:   0.5024 T12:   0.0736                                     
REMARK   3      T13:  -0.0308 T23:   0.0205                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  12.6105 L22:   2.7370                                     
REMARK   3      L33:   4.5116 L12:   2.7673                                     
REMARK   3      L13:  -3.5105 L23:   0.4174                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0198 S12:  -0.2296 S13:  -0.5038                       
REMARK   3      S21:   0.2170 S22:   0.0010 S23:  -0.0438                       
REMARK   3      S31:   0.5653 S32:   0.1227 S33:   0.0188                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 91                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   150        F   155                          
REMARK   3    ORIGIN FOR THE GROUP (A):  44.5395 -48.6599 115.7307              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5813 T22:   0.2571                                     
REMARK   3      T33:   1.0981 T12:   0.1158                                     
REMARK   3      T13:   0.0062 T23:  -0.0962                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  38.2100 L22:   4.8632                                     
REMARK   3      L33:  21.1899 L12:  -1.4206                                     
REMARK   3      L13: -10.6461 L23:  -8.9669                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1714 S12:   1.6269 S13:  -3.1464                       
REMARK   3      S21:  -0.2628 S22:  -0.8679 S23:   0.7183                       
REMARK   3      S31:   0.0953 S32:   1.1094 S33:  -0.3035                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : MASK                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 3P8C COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-OCT-10.                  
REMARK 100 THE DEPOSITION ID IS D_1000062083.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 15-AUG-09                          
REMARK 200  TEMPERATURE           (KELVIN) : 150                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 2                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 19-ID                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.97924                            
REMARK 200  MONOCHROMATOR                  : SAGITALLY FOCUSED SI(111)          
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R                  
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-3000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-3000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 144578                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.280                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 47.980                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 88.0                               
REMARK 200  DATA REDUNDANCY                : 2.500                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.06500                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 12.4000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.28                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.31                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 28.3                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.60                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.19600                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 3.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MIRAS                        
REMARK 200 SOFTWARE USED: MLPHARE                                               
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 54.70                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.72                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 10 % (W/V) GLYCEROL, 4 % PEG 10,000,     
REMARK 280  12-20 % PEG 300, 100 MM TRIS-HCL, 2 MM TCEP, 2 MM EDTA, PH 8.5,     
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       48.50650            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      163.59650            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       56.99100            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      163.59650            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       48.50650            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       56.99100            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: PENTAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 41520 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 111710 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -296.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, D, E, F                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     GLN A     4                                                      
REMARK 465     PRO A    23                                                      
REMARK 465     ASP A    24                                                      
REMARK 465     GLN A    25                                                      
REMARK 465     GLN A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     CYS A    28                                                      
REMARK 465     ILE A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     PRO A    31                                                      
REMARK 465     PRO A    32                                                      
REMARK 465     PRO A    33                                                      
REMARK 465     SER A    34                                                      
REMARK 465     SER A    35                                                      
REMARK 465     LEU A    36                                                      
REMARK 465     LEU A    37                                                      
REMARK 465     TYR A    38                                                      
REMARK 465     GLN A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     ASN A    41                                                      
REMARK 465     PHE A    42                                                      
REMARK 465     ASN A    43                                                      
REMARK 465     THR A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     PHE A    46                                                      
REMARK 465     GLU A    47                                                      
REMARK 465     ASP A    48                                                      
REMARK 465     ARG A    49                                                      
REMARK 465     ASN A    50                                                      
REMARK 465     ALA A    51                                                      
REMARK 465     PHE A    52                                                      
REMARK 465     VAL A    53                                                      
REMARK 465     THR A    54                                                      
REMARK 465     GLY A    55                                                      
REMARK 465     ILE A    56                                                      
REMARK 465     GLY A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     SER A   340                                                      
REMARK 465     PRO A   341                                                      
REMARK 465     GLN A   342                                                      
REMARK 465     TYR A   343                                                      
REMARK 465     ASN A   344                                                      
REMARK 465     ASN A   368                                                      
REMARK 465     SER A   369                                                      
REMARK 465     GLU A   370                                                      
REMARK 465     VAL A   371                                                      
REMARK 465     VAL A   372                                                      
REMARK 465     THR A   373                                                      
REMARK 465     GLY A   374                                                      
REMARK 465     SER A   375                                                      
REMARK 465     GLY A   376                                                      
REMARK 465     ARG A   377                                                      
REMARK 465     GLN A   378                                                      
REMARK 465     GLU A   379                                                      
REMARK 465     LYS A   540                                                      
REMARK 465     SER A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     ASP A   572                                                      
REMARK 465     LYS A   573                                                      
REMARK 465     SER A   574                                                      
REMARK 465     GLY A   575                                                      
REMARK 465     SER A   576                                                      
REMARK 465     LYS A   577                                                      
REMARK 465     SER A  1228                                                      
REMARK 465     GLY A  1229                                                      
REMARK 465     ASP A  1230                                                      
REMARK 465     GLY A  1231                                                      
REMARK 465     GLU A  1232                                                      
REMARK 465     GLY A  1233                                                      
REMARK 465     THR A  1234                                                      
REMARK 465     PRO A  1235                                                      
REMARK 465     VAL A  1236                                                      
REMARK 465     ALA A  1251                                                      
REMARK 465     SER A  1252                                                      
REMARK 465     SER A  1253                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     ARG B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     LEU B     6                                                      
REMARK 465     THR B    69                                                      
REMARK 465     ARG B    70                                                      
REMARK 465     ASN B    71                                                      
REMARK 465     ASN B    72                                                      
REMARK 465     LYS B   644                                                      
REMARK 465     SER B   645                                                      
REMARK 465     LYS B   646                                                      
REMARK 465     LYS B   647                                                      
REMARK 465     GLN B   648                                                      
REMARK 465     THR B   649                                                      
REMARK 465     GLY B   650                                                      
REMARK 465     LYS B   651                                                      
REMARK 465     LYS B   652                                                      
REMARK 465     GLY B   653                                                      
REMARK 465     GLU B   654                                                      
REMARK 465     PRO B   655                                                      
REMARK 465     GLU B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ILE B   946                                                      
REMARK 465     PRO B   947                                                      
REMARK 465     ARG B   948                                                      
REMARK 465     GLU B   949                                                      
REMARK 465     THR B   950                                                      
REMARK 465     GLN B   982                                                      
REMARK 465     LYS B   983                                                      
REMARK 465     SER B   984                                                      
REMARK 465     GLU B   985                                                      
REMARK 465     ASN B   986                                                      
REMARK 465     ILE B   987                                                      
REMARK 465     GLN B  1122                                                      
REMARK 465     SER B  1123                                                      
REMARK 465     VAL B  1124                                                      
REMARK 465     THR B  1125                                                      
REMARK 465     SER B  1126                                                      
REMARK 465     SER B  1127                                                      
REMARK 465     ALA B  1128                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     VAL D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     ARG D     6                                                      
REMARK 465     ASN D     7                                                      
REMARK 465     ILE D     8                                                      
REMARK 465     ASP D     9                                                      
REMARK 465     PRO D    10                                                      
REMARK 465     ARG D    11                                                      
REMARK 465     HIS D    12                                                      
REMARK 465     LEU D    13                                                      
REMARK 465     CYS D    14                                                      
REMARK 465     HIS D    15                                                      
REMARK 465     THR D    16                                                      
REMARK 465     ALA D    17                                                      
REMARK 465     LEU D    18                                                      
REMARK 465     PRO D    19                                                      
REMARK 465     ARG D    20                                                      
REMARK 465     ASP D   185                                                      
REMARK 465     ARG D   186                                                      
REMARK 465     GLY D   187                                                      
REMARK 465     GLY D   188                                                      
REMARK 465     SER D   189                                                      
REMARK 465     GLY D   190                                                      
REMARK 465     GLY D   191                                                      
REMARK 465     SER D   192                                                      
REMARK 465     GLY D   193                                                      
REMARK 465     GLY D   194                                                      
REMARK 465     SER D   195                                                      
REMARK 465     GLY D   196                                                      
REMARK 465     GLY D   197                                                      
REMARK 465     SER D   198                                                      
REMARK 465     GLY D   199                                                      
REMARK 465     GLY D   200                                                      
REMARK 465     SER D   201                                                      
REMARK 465     GLY D   202                                                      
REMARK 465     GLY D   203                                                      
REMARK 465     SER D   204                                                      
REMARK 465     LYS D   205                                                      
REMARK 465     ARG D   206                                                      
REMARK 465     HIS D   207                                                      
REMARK 465     PRO D   208                                                      
REMARK 465     SER D   209                                                      
REMARK 465     THR D   210                                                      
REMARK 465     LEU D   211                                                      
REMARK 465     PRO D   212                                                      
REMARK 465     VAL D   213                                                      
REMARK 465     ILE D   214                                                      
REMARK 465     SER D   215                                                      
REMARK 465     GLU D   239                                                      
REMARK 465     GLN D   240                                                      
REMARK 465     GLU D   241                                                      
REMARK 465     ALA D   242                                                      
REMARK 465     LYS D   243                                                      
REMARK 465     HIS D   244                                                      
REMARK 465     GLU D   245                                                      
REMARK 465     ARG D   246                                                      
REMARK 465     ILE D   247                                                      
REMARK 465     ASP D   265                                                      
REMARK 465     SER D   266                                                      
REMARK 465     GLU D   267                                                      
REMARK 465     ASP D   268                                                      
REMARK 465     ASP D   269                                                      
REMARK 465     SER D   270                                                      
REMARK 465     GLU D   271                                                      
REMARK 465     PHE D   272                                                      
REMARK 465     ASP D   273                                                      
REMARK 465     GLU D   274                                                      
REMARK 465     VAL D   275                                                      
REMARK 465     ASP D   276                                                      
REMARK 465     TRP D   277                                                      
REMARK 465     LEU D   278                                                      
REMARK 465     GLU D   279                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     GLN E     4                                                      
REMARK 465     GLU E     5                                                      
REMARK 465     ASP E     6                                                      
REMARK 465     PRO E     7                                                      
REMARK 465     VAL E     8                                                      
REMARK 465     GLN E     9                                                      
REMARK 465     LEU E    74                                                      
REMARK 465     THR E    75                                                      
REMARK 465     SER F   156                                                      
REMARK 465     THR F   157                                                      
REMARK 465     GLN F   158                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A 255      -62.41   -120.78                                   
REMARK 500    HIS A 418       72.42   -118.07                                   
REMARK 500    THR A 439      -89.74   -106.27                                   
REMARK 500    ALA A 551       58.41    -98.42                                   
REMARK 500    ASN A 607       53.56    -93.99                                   
REMARK 500    ARG A 624       32.92   -148.85                                   
REMARK 500    GLU A 657      107.29    -58.59                                   
REMARK 500    ASP A 850      -52.86   -128.39                                   
REMARK 500    LEU A 888     -114.79   -113.65                                   
REMARK 500    ASN A1030       -2.68     71.79                                   
REMARK 500    VAL A1118      -68.97   -125.84                                   
REMARK 500    VAL A1121      -64.58   -129.50                                   
REMARK 500    CYS A1124       72.82   -111.33                                   
REMARK 500    LEU A1226       38.77    -79.86                                   
REMARK 500    GLN B 118       72.04     40.67                                   
REMARK 500    VAL B 125      -71.03   -127.98                                   
REMARK 500    VAL B 213      -58.44   -130.85                                   
REMARK 500    CYS B 269       55.88   -117.75                                   
REMARK 500    ARG B 297     -120.95     54.09                                   
REMARK 500    PHE B 437      -58.69   -139.74                                   
REMARK 500    VAL B 641       57.63    -97.59                                   
REMARK 500    ASN B 642      -49.57   -153.19                                   
REMARK 500    GLU B 699       -5.94     65.64                                   
REMARK 500    LYS B1048       25.12     46.68                                   
REMARK 500    LYS D 174       33.17    -97.34                                   
REMARK 500    LYS D 182       51.72    -90.77                                   
REMARK 500    ASN D 183      -70.28   -152.54                                   
REMARK 500    GLU D 236      -63.23   -137.31                                   
REMARK 500    GLN D 237       71.73   -107.89                                   
REMARK 500    GLU F  10      -58.13   -126.19                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TRS A 1254                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 1258                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1259                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1260                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1261                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1129                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1131                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1132                
DBREF  3P8C A    1  1253  UNP    Q7L576   CYFP1_HUMAN      1   1253             
DBREF  3P8C B    1  1128  UNP    Q9Y2A7   NCKP1_HUMAN      1   1128             
DBREF  3P8C D    1   186  UNP    Q92558   WASF1_HUMAN      1    186             
DBREF  3P8C D  205   279  UNP    Q92558   WASF1_HUMAN    485    559             
DBREF  3P8C E    1    75  UNP    Q8WUW1   BRK1_HUMAN       1     75             
DBREF  3P8C F    1   158  UNP    B4DSN1   B4DSN1_HUMAN     1    158             
SEQADV 3P8C GLY D  187  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  188  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  189  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  190  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  191  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  192  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  193  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  194  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  195  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  196  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  197  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  198  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  199  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  200  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  201  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  202  UNP  Q92558              LINKER                         
SEQADV 3P8C GLY D  203  UNP  Q92558              LINKER                         
SEQADV 3P8C SER D  204  UNP  Q92558              LINKER                         
SEQADV 3P8C ALA F    0  UNP  B4DSN1              EXPRESSION TAG                 
SEQRES   1 A 1253  MET ALA ALA GLN VAL THR LEU GLU ASP ALA LEU SER ASN          
SEQRES   2 A 1253  VAL ASP LEU LEU GLU GLU LEU PRO LEU PRO ASP GLN GLN          
SEQRES   3 A 1253  PRO CYS ILE GLU PRO PRO PRO SER SER LEU LEU TYR GLN          
SEQRES   4 A 1253  PRO ASN PHE ASN THR ASN PHE GLU ASP ARG ASN ALA PHE          
SEQRES   5 A 1253  VAL THR GLY ILE ALA ARG TYR ILE GLU GLN ALA THR VAL          
SEQRES   6 A 1253  HIS SER SER MET ASN GLU MET LEU GLU GLU GLY GLN GLU          
SEQRES   7 A 1253  TYR ALA VAL MET LEU TYR THR TRP ARG SER CYS SER ARG          
SEQRES   8 A 1253  ALA ILE PRO GLN VAL LYS CYS ASN GLU GLN PRO ASN ARG          
SEQRES   9 A 1253  VAL GLU ILE TYR GLU LYS THR VAL GLU VAL LEU GLU PRO          
SEQRES  10 A 1253  GLU VAL THR LYS LEU MET ASN PHE MET TYR PHE GLN ARG          
SEQRES  11 A 1253  ASN ALA ILE GLU ARG PHE CYS GLY GLU VAL ARG ARG LEU          
SEQRES  12 A 1253  CYS HIS ALA GLU ARG ARG LYS ASP PHE VAL SER GLU ALA          
SEQRES  13 A 1253  TYR LEU ILE THR LEU GLY LYS PHE ILE ASN MET PHE ALA          
SEQRES  14 A 1253  VAL LEU ASP GLU LEU LYS ASN MET LYS CYS SER VAL LYS          
SEQRES  15 A 1253  ASN ASP HIS SER ALA TYR LYS ARG ALA ALA GLN PHE LEU          
SEQRES  16 A 1253  ARG LYS MET ALA ASP PRO GLN SER ILE GLN GLU SER GLN          
SEQRES  17 A 1253  ASN LEU SER MET PHE LEU ALA ASN HIS ASN LYS ILE THR          
SEQRES  18 A 1253  GLN SER LEU GLN GLN GLN LEU GLU VAL ILE SER GLY TYR          
SEQRES  19 A 1253  GLU GLU LEU LEU ALA ASP ILE VAL ASN LEU CYS VAL ASP          
SEQRES  20 A 1253  TYR TYR GLU ASN ARG MET TYR LEU THR PRO SER GLU LYS          
SEQRES  21 A 1253  HIS MET LEU LEU LYS VAL MET GLY PHE GLY LEU TYR LEU          
SEQRES  22 A 1253  MET ASP GLY SER VAL SER ASN ILE TYR LYS LEU ASP ALA          
SEQRES  23 A 1253  LYS LYS ARG ILE ASN LEU SER LYS ILE ASP LYS TYR PHE          
SEQRES  24 A 1253  LYS GLN LEU GLN VAL VAL PRO LEU PHE GLY ASP MET GLN          
SEQRES  25 A 1253  ILE GLU LEU ALA ARG TYR ILE LYS THR SER ALA HIS TYR          
SEQRES  26 A 1253  GLU GLU ASN LYS SER ARG TRP THR CYS THR SER SER GLY          
SEQRES  27 A 1253  SER SER PRO GLN TYR ASN ILE CYS GLU GLN MET ILE GLN          
SEQRES  28 A 1253  ILE ARG GLU ASP HIS MET ARG PHE ILE SER GLU LEU ALA          
SEQRES  29 A 1253  ARG TYR SER ASN SER GLU VAL VAL THR GLY SER GLY ARG          
SEQRES  30 A 1253  GLN GLU ALA GLN LYS THR ASP ALA GLU TYR ARG LYS LEU          
SEQRES  31 A 1253  PHE ASP LEU ALA LEU GLN GLY LEU GLN LEU LEU SER GLN          
SEQRES  32 A 1253  TRP SER ALA HIS VAL MET GLU VAL TYR SER TRP LYS LEU          
SEQRES  33 A 1253  VAL HIS PRO THR ASP LYS TYR SER ASN LYS ASP CYS PRO          
SEQRES  34 A 1253  ASP SER ALA GLU GLU TYR GLU ARG ALA THR ARG TYR ASN          
SEQRES  35 A 1253  TYR THR SER GLU GLU LYS PHE ALA LEU VAL GLU VAL ILE          
SEQRES  36 A 1253  ALA MET ILE LYS GLY LEU GLN VAL LEU MET GLY ARG MET          
SEQRES  37 A 1253  GLU SER VAL PHE ASN HIS ALA ILE ARG HIS THR VAL TYR          
SEQRES  38 A 1253  ALA ALA LEU GLN ASP PHE SER GLN VAL THR LEU ARG GLU          
SEQRES  39 A 1253  PRO LEU ARG GLN ALA ILE LYS LYS LYS LYS ASN VAL ILE          
SEQRES  40 A 1253  GLN SER VAL LEU GLN ALA ILE ARG LYS THR VAL CYS ASP          
SEQRES  41 A 1253  TRP GLU THR GLY HIS GLU PRO PHE ASN ASP PRO ALA LEU          
SEQRES  42 A 1253  ARG GLY GLU LYS ASP PRO LYS SER GLY PHE ASP ILE LYS          
SEQRES  43 A 1253  VAL PRO ARG ARG ALA VAL GLY PRO SER SER THR GLN LEU          
SEQRES  44 A 1253  TYR MET VAL ARG THR MET LEU GLU SER LEU ILE ALA ASP          
SEQRES  45 A 1253  LYS SER GLY SER LYS LYS THR LEU ARG SER SER LEU GLU          
SEQRES  46 A 1253  GLY PRO THR ILE LEU ASP ILE GLU LYS PHE HIS ARG GLU          
SEQRES  47 A 1253  SER PHE PHE TYR THR HIS LEU ILE ASN PHE SER GLU THR          
SEQRES  48 A 1253  LEU GLN GLN CYS CYS ASP LEU SER GLN LEU TRP PHE ARG          
SEQRES  49 A 1253  GLU PHE PHE LEU GLU LEU THR MET GLY ARG ARG ILE GLN          
SEQRES  50 A 1253  PHE PRO ILE GLU MET SER MET PRO TRP ILE LEU THR ASP          
SEQRES  51 A 1253  HIS ILE LEU GLU THR LYS GLU ALA SER MET MET GLU TYR          
SEQRES  52 A 1253  VAL LEU TYR SER LEU ASP LEU TYR ASN ASP SER ALA HIS          
SEQRES  53 A 1253  TYR ALA LEU THR ARG PHE ASN LYS GLN PHE LEU TYR ASP          
SEQRES  54 A 1253  GLU ILE GLU ALA GLU VAL ASN LEU CYS PHE ASP GLN PHE          
SEQRES  55 A 1253  VAL TYR LYS LEU ALA ASP GLN ILE PHE ALA TYR TYR LYS          
SEQRES  56 A 1253  VAL MET ALA GLY SER LEU LEU LEU ASP LYS ARG LEU ARG          
SEQRES  57 A 1253  SER GLU CYS LYS ASN GLN GLY ALA THR ILE HIS LEU PRO          
SEQRES  58 A 1253  PRO SER ASN ARG TYR GLU THR LEU LEU LYS GLN ARG HIS          
SEQRES  59 A 1253  VAL GLN LEU LEU GLY ARG SER ILE ASP LEU ASN ARG LEU          
SEQRES  60 A 1253  ILE THR GLN ARG VAL SER ALA ALA MET TYR LYS SER LEU          
SEQRES  61 A 1253  GLU LEU ALA ILE GLY ARG PHE GLU SER GLU ASP LEU THR          
SEQRES  62 A 1253  SER ILE VAL GLU LEU ASP GLY LEU LEU GLU ILE ASN ARG          
SEQRES  63 A 1253  MET THR HIS LYS LEU LEU SER ARG TYR LEU THR LEU ASP          
SEQRES  64 A 1253  GLY PHE ASP ALA MET PHE ARG GLU ALA ASN HIS ASN VAL          
SEQRES  65 A 1253  SER ALA PRO TYR GLY ARG ILE THR LEU HIS VAL PHE TRP          
SEQRES  66 A 1253  GLU LEU ASN TYR ASP PHE LEU PRO ASN TYR CYS TYR ASN          
SEQRES  67 A 1253  GLY SER THR ASN ARG PHE VAL ARG THR VAL LEU PRO PHE          
SEQRES  68 A 1253  SER GLN GLU PHE GLN ARG ASP LYS GLN PRO ASN ALA GLN          
SEQRES  69 A 1253  PRO GLN TYR LEU HIS GLY SER LYS ALA LEU ASN LEU ALA          
SEQRES  70 A 1253  TYR SER SER ILE TYR GLY SER TYR ARG ASN PHE VAL GLY          
SEQRES  71 A 1253  PRO PRO HIS PHE GLN VAL ILE CYS ARG LEU LEU GLY TYR          
SEQRES  72 A 1253  GLN GLY ILE ALA VAL VAL MET GLU GLU LEU LEU LYS VAL          
SEQRES  73 A 1253  VAL LYS SER LEU LEU GLN GLY THR ILE LEU GLN TYR VAL          
SEQRES  74 A 1253  LYS THR LEU MET GLU VAL MET PRO LYS ILE CYS ARG LEU          
SEQRES  75 A 1253  PRO ARG HIS GLU TYR GLY SER PRO GLY ILE LEU GLU PHE          
SEQRES  76 A 1253  PHE HIS HIS GLN LEU LYS ASP ILE VAL GLU TYR ALA GLU          
SEQRES  77 A 1253  LEU LYS THR VAL CYS PHE GLN ASN LEU ARG GLU VAL GLY          
SEQRES  78 A 1253  ASN ALA ILE LEU PHE CYS LEU LEU ILE GLU GLN SER LEU          
SEQRES  79 A 1253  SER LEU GLU GLU VAL CYS ASP LEU LEU HIS ALA ALA PRO          
SEQRES  80 A 1253  PHE GLN ASN ILE LEU PRO ARG VAL HIS VAL LYS GLU GLY          
SEQRES  81 A 1253  GLU ARG LEU ASP ALA LYS MET LYS ARG LEU GLU SER LYS          
SEQRES  82 A 1253  TYR ALA PRO LEU HIS LEU VAL PRO LEU ILE GLU ARG LEU          
SEQRES  83 A 1253  GLY THR PRO GLN GLN ILE ALA ILE ALA ARG GLU GLY ASP          
SEQRES  84 A 1253  LEU LEU THR LYS GLU ARG LEU CYS CYS GLY LEU SER MET          
SEQRES  85 A 1253  PHE GLU VAL ILE LEU THR ARG ILE ARG SER PHE LEU ASP          
SEQRES  86 A 1253  ASP PRO ILE TRP ARG GLY PRO LEU PRO SER ASN GLY VAL          
SEQRES  87 A 1253  MET HIS VAL ASP GLU CYS VAL GLU PHE HIS ARG LEU TRP          
SEQRES  88 A 1253  SER ALA MET GLN PHE VAL TYR CYS ILE PRO VAL GLY THR          
SEQRES  89 A 1253  HIS GLU PHE THR VAL GLU GLN CYS PHE GLY ASP GLY LEU          
SEQRES  90 A 1253  HIS TRP ALA GLY CYS MET ILE ILE VAL LEU LEU GLY GLN          
SEQRES  91 A 1253  GLN ARG ARG PHE ALA VAL LEU ASP PHE CYS TYR HIS LEU          
SEQRES  92 A 1253  LEU LYS VAL GLN LYS HIS ASP GLY LYS ASP GLU ILE ILE          
SEQRES  93 A 1253  LYS ASN VAL PRO LEU LYS LYS MET VAL GLU ARG ILE ARG          
SEQRES  94 A 1253  LYS PHE GLN ILE LEU ASN ASP GLU ILE ILE THR ILE LEU          
SEQRES  95 A 1253  ASP LYS TYR LEU LYS SER GLY ASP GLY GLU GLY THR PRO          
SEQRES  96 A 1253  VAL GLU HIS VAL ARG CYS PHE GLN PRO PRO ILE HIS GLN          
SEQRES  97 A 1253  SER LEU ALA SER SER                                          
SEQRES   1 B 1128  MET SER ARG SER VAL LEU GLN PRO SER GLN GLN LYS LEU          
SEQRES   2 B 1128  ALA GLU LYS LEU THR ILE LEU ASN ASP ARG GLY VAL GLY          
SEQRES   3 B 1128  MET LEU THR ARG LEU TYR ASN ILE LYS LYS ALA CYS GLY          
SEQRES   4 B 1128  ASP PRO LYS ALA LYS PRO SER TYR LEU ILE ASP LYS ASN          
SEQRES   5 B 1128  LEU GLU SER ALA VAL LYS PHE ILE VAL ARG LYS PHE PRO          
SEQRES   6 B 1128  ALA VAL GLU THR ARG ASN ASN ASN GLN GLN LEU ALA GLN          
SEQRES   7 B 1128  LEU GLN LYS GLU LYS SER GLU ILE LEU LYS ASN LEU ALA          
SEQRES   8 B 1128  LEU TYR TYR PHE THR PHE VAL ASP VAL MET GLU PHE LYS          
SEQRES   9 B 1128  ASP HIS VAL CYS GLU LEU LEU ASN THR ILE ASP VAL CYS          
SEQRES  10 B 1128  GLN VAL PHE PHE ASP ILE THR VAL ASN PHE ASP LEU THR          
SEQRES  11 B 1128  LYS ASN TYR LEU ASP LEU ILE ILE THR TYR THR THR LEU          
SEQRES  12 B 1128  MET ILE LEU LEU SER ARG ILE GLU GLU ARG LYS ALA ILE          
SEQRES  13 B 1128  ILE GLY LEU TYR ASN TYR ALA HIS GLU MET THR HIS GLY          
SEQRES  14 B 1128  ALA SER ASP ARG GLU TYR PRO ARG LEU GLY GLN MET ILE          
SEQRES  15 B 1128  VAL ASP TYR GLU ASN PRO LEU LYS LYS MET MET GLU GLU          
SEQRES  16 B 1128  PHE VAL PRO HIS SER LYS SER LEU SER ASP ALA LEU ILE          
SEQRES  17 B 1128  SER LEU GLN MET VAL TYR PRO ARG ARG ASN LEU SER ALA          
SEQRES  18 B 1128  ASP GLN TRP ARG ASN ALA GLN LEU LEU SER LEU ILE SER          
SEQRES  19 B 1128  ALA PRO SER THR MET LEU ASN PRO ALA GLN SER ASP THR          
SEQRES  20 B 1128  MET PRO CYS GLU TYR LEU SER LEU ASP ALA MET GLU LYS          
SEQRES  21 B 1128  TRP ILE ILE PHE GLY PHE ILE LEU CYS HIS GLY ILE LEU          
SEQRES  22 B 1128  ASN THR ASP ALA THR ALA LEU ASN LEU TRP LYS LEU ALA          
SEQRES  23 B 1128  LEU GLN SER SER SER CYS LEU SER LEU PHE ARG ASP GLU          
SEQRES  24 B 1128  VAL PHE HIS ILE HIS LYS ALA ALA GLU ASP LEU PHE VAL          
SEQRES  25 B 1128  ASN ILE ARG GLY TYR ASN LYS ARG ILE ASN ASP ILE ARG          
SEQRES  26 B 1128  GLU CYS LYS GLU ALA ALA VAL SER HIS ALA GLY SER MET          
SEQRES  27 B 1128  HIS ARG GLU ARG ARG LYS PHE LEU ARG SER ALA LEU LYS          
SEQRES  28 B 1128  GLU LEU ALA THR VAL LEU SER ASP GLN PRO GLY LEU LEU          
SEQRES  29 B 1128  GLY PRO LYS ALA LEU PHE VAL PHE MET ALA LEU SER PHE          
SEQRES  30 B 1128  ALA ARG ASP GLU ILE ILE TRP LEU LEU ARG HIS ALA ASP          
SEQRES  31 B 1128  ASN MET PRO LYS LYS SER ALA ASP ASP PHE ILE ASP LYS          
SEQRES  32 B 1128  HIS ILE ALA GLU LEU ILE PHE TYR MET GLU GLU LEU ARG          
SEQRES  33 B 1128  ALA HIS VAL ARG LYS TYR GLY PRO VAL MET GLN ARG TYR          
SEQRES  34 B 1128  TYR VAL GLN TYR LEU SER GLY PHE ASP ALA VAL VAL LEU          
SEQRES  35 B 1128  ASN GLU LEU VAL GLN ASN LEU SER VAL CYS PRO GLU ASP          
SEQRES  36 B 1128  GLU SER ILE ILE MET SER SER PHE VAL ASN THR MET THR          
SEQRES  37 B 1128  SER LEU SER VAL LYS GLN VAL GLU ASP GLY GLU VAL PHE          
SEQRES  38 B 1128  ASP PHE ARG GLY MET ARG LEU ASP TRP PHE ARG LEU GLN          
SEQRES  39 B 1128  ALA TYR THR SER VAL SER LYS ALA SER LEU GLY LEU ALA          
SEQRES  40 B 1128  ASP HIS ARG GLU LEU GLY LYS MET MET ASN THR ILE ILE          
SEQRES  41 B 1128  PHE HIS THR LYS MET VAL ASP SER LEU VAL GLU MET LEU          
SEQRES  42 B 1128  VAL GLU THR SER ASP LEU SER ILE PHE CYS PHE TYR SER          
SEQRES  43 B 1128  ARG ALA PHE GLU LYS MET PHE GLN GLN CYS LEU GLU LEU          
SEQRES  44 B 1128  PRO SER GLN SER ARG TYR SER ILE ALA PHE PRO LEU LEU          
SEQRES  45 B 1128  CYS THR HIS PHE MET SER CYS THR HIS GLU LEU CYS PRO          
SEQRES  46 B 1128  GLU GLU ARG HIS HIS ILE GLY ASP ARG SER LEU SER LEU          
SEQRES  47 B 1128  CYS ASN MET PHE LEU ASP GLU MET ALA LYS GLN ALA ARG          
SEQRES  48 B 1128  ASN LEU ILE THR ASP ILE CYS THR GLU GLN CYS THR LEU          
SEQRES  49 B 1128  SER ASP GLN LEU LEU PRO LYS HIS CYS ALA LYS THR ILE          
SEQRES  50 B 1128  SER GLN ALA VAL ASN LYS LYS SER LYS LYS GLN THR GLY          
SEQRES  51 B 1128  LYS LYS GLY GLU PRO GLU ARG GLU LYS PRO GLY VAL GLU          
SEQRES  52 B 1128  SER MET ARG LYS ASN ARG LEU VAL VAL THR ASN LEU ASP          
SEQRES  53 B 1128  LYS LEU HIS THR ALA LEU SER GLU LEU CYS PHE SER ILE          
SEQRES  54 B 1128  ASN TYR VAL PRO ASN MET VAL VAL TRP GLU HIS THR PHE          
SEQRES  55 B 1128  THR PRO ARG GLU TYR LEU THR SER HIS LEU GLU ILE ARG          
SEQRES  56 B 1128  PHE THR LYS SER ILE VAL GLY MET THR MET TYR ASN GLN          
SEQRES  57 B 1128  ALA THR GLN GLU ILE ALA LYS PRO SER GLU LEU LEU THR          
SEQRES  58 B 1128  SER VAL ARG ALA TYR MET THR VAL LEU GLN SER ILE GLU          
SEQRES  59 B 1128  ASN TYR VAL GLN ILE ASP ILE THR ARG VAL PHE ASN ASN          
SEQRES  60 B 1128  VAL LEU LEU GLN GLN THR GLN HIS LEU ASP SER HIS GLY          
SEQRES  61 B 1128  GLU PRO THR ILE THR SER LEU TYR THR ASN TRP TYR LEU          
SEQRES  62 B 1128  GLU THR LEU LEU ARG GLN VAL SER ASN GLY HIS ILE ALA          
SEQRES  63 B 1128  TYR PHE PRO ALA MET LYS ALA PHE VAL ASN LEU PRO THR          
SEQRES  64 B 1128  GLU ASN GLU LEU THR PHE ASN ALA GLU GLU TYR SER ASP          
SEQRES  65 B 1128  ILE SER GLU MET ARG SER LEU SER GLU LEU LEU GLY PRO          
SEQRES  66 B 1128  TYR GLY MET LYS PHE LEU SER GLU SER LEU MET TRP HIS          
SEQRES  67 B 1128  ILE SER SER GLN VAL ALA GLU LEU LYS LYS LEU VAL VAL          
SEQRES  68 B 1128  GLU ASN VAL ASP VAL LEU THR GLN MET ARG THR SER PHE          
SEQRES  69 B 1128  ASP LYS PRO ASP GLN MET ALA ALA LEU PHE LYS ARG LEU          
SEQRES  70 B 1128  SER SER VAL ASP SER VAL LEU LYS ARG MET THR ILE ILE          
SEQRES  71 B 1128  GLY VAL ILE LEU SER PHE ARG SER LEU ALA GLN GLU ALA          
SEQRES  72 B 1128  LEU ARG ASP VAL LEU SER TYR HIS ILE PRO PHE LEU VAL          
SEQRES  73 B 1128  SER SER ILE GLU ASP PHE LYS ASP HIS ILE PRO ARG GLU          
SEQRES  74 B 1128  THR ASP MET LYS VAL ALA MET ASN VAL TYR GLU LEU SER          
SEQRES  75 B 1128  SER ALA ALA GLY LEU PRO CYS GLU ILE ASP PRO ALA LEU          
SEQRES  76 B 1128  VAL VAL ALA LEU SER SER GLN LYS SER GLU ASN ILE SER          
SEQRES  77 B 1128  PRO GLU GLU GLU TYR LYS ILE ALA CYS LEU LEU MET VAL          
SEQRES  78 B 1128  PHE VAL ALA VAL SER LEU PRO THR LEU ALA SER ASN VAL          
SEQRES  79 B 1128  MET SER GLN TYR SER PRO ALA ILE GLU GLY HIS CYS ASN          
SEQRES  80 B 1128  ASN ILE HIS CYS LEU ALA LYS ALA ILE ASN GLN ILE ALA          
SEQRES  81 B 1128  ALA ALA LEU PHE THR ILE HIS LYS GLY SER ILE GLU ASP          
SEQRES  82 B 1128  ARG LEU LYS GLU PHE LEU ALA LEU ALA SER SER SER LEU          
SEQRES  83 B 1128  LEU LYS ILE GLY GLN GLU THR ASP LYS THR THR THR ARG          
SEQRES  84 B 1128  ASN ARG GLU SER VAL TYR LEU LEU LEU ASP MET ILE VAL          
SEQRES  85 B 1128  GLN GLU SER PRO PHE LEU THR MET ASP LEU LEU GLU SER          
SEQRES  86 B 1128  CYS PHE PRO TYR VAL LEU LEU ARG ASN ALA TYR HIS ALA          
SEQRES  87 B 1128  VAL TYR LYS GLN SER VAL THR SER SER ALA                      
SEQRES   1 D  279  MET PRO LEU VAL LYS ARG ASN ILE ASP PRO ARG HIS LEU          
SEQRES   2 D  279  CYS HIS THR ALA LEU PRO ARG GLY ILE LYS ASN GLU LEU          
SEQRES   3 D  279  GLU CYS VAL THR ASN ILE SER LEU ALA ASN ILE ILE ARG          
SEQRES   4 D  279  GLN LEU SER SER LEU SER LYS TYR ALA GLU ASP ILE PHE          
SEQRES   5 D  279  GLY GLU LEU PHE ASN GLU ALA HIS SER PHE SER PHE ARG          
SEQRES   6 D  279  VAL ASN SER LEU GLN GLU ARG VAL ASP ARG LEU SER VAL          
SEQRES   7 D  279  SER VAL THR GLN LEU ASP PRO LYS GLU GLU GLU LEU SER          
SEQRES   8 D  279  LEU GLN ASP ILE THR MET ARG LYS ALA PHE ARG SER SER          
SEQRES   9 D  279  THR ILE GLN ASP GLN GLN LEU PHE ASP ARG LYS THR LEU          
SEQRES  10 D  279  PRO ILE PRO LEU GLN GLU THR TYR ASP VAL CYS GLU GLN          
SEQRES  11 D  279  PRO PRO PRO LEU ASN ILE LEU THR PRO TYR ARG ASP ASP          
SEQRES  12 D  279  GLY LYS GLU GLY LEU LYS PHE TYR THR ASN PRO SER TYR          
SEQRES  13 D  279  PHE PHE ASP LEU TRP LYS GLU LYS MET LEU GLN ASP THR          
SEQRES  14 D  279  GLU ASP LYS ARG LYS GLU LYS ARG LYS GLN LYS GLN LYS          
SEQRES  15 D  279  ASN LEU ASP ARG GLY GLY SER GLY GLY SER GLY GLY SER          
SEQRES  16 D  279  GLY GLY SER GLY GLY SER GLY GLY SER LYS ARG HIS PRO          
SEQRES  17 D  279  SER THR LEU PRO VAL ILE SER ASP ALA ARG SER VAL LEU          
SEQRES  18 D  279  LEU GLU ALA ILE ARG LYS GLY ILE GLN LEU ARG LYS VAL          
SEQRES  19 D  279  GLU GLU GLN ARG GLU GLN GLU ALA LYS HIS GLU ARG ILE          
SEQRES  20 D  279  GLU ASN ASP VAL ALA THR ILE LEU SER ARG ARG ILE ALA          
SEQRES  21 D  279  VAL GLU TYR SER ASP SER GLU ASP ASP SER GLU PHE ASP          
SEQRES  22 D  279  GLU VAL ASP TRP LEU GLU                                      
SEQRES   1 E   75  MET ALA GLY GLN GLU ASP PRO VAL GLN ARG GLU ILE HIS          
SEQRES   2 E   75  GLN ASP TRP ALA ASN ARG GLU TYR ILE GLU ILE ILE THR          
SEQRES   3 E   75  SER SER ILE LYS LYS ILE ALA ASP PHE LEU ASN SER PHE          
SEQRES   4 E   75  ASP MET SER CYS ARG SER ARG LEU ALA THR LEU ASN GLU          
SEQRES   5 E   75  LYS LEU THR ALA LEU GLU ARG ARG ILE GLU TYR ILE GLU          
SEQRES   6 E   75  ALA ARG VAL THR LYS GLY GLU THR LEU THR                      
SEQRES   1 F  159  ALA MET ALA GLU LEU GLN MET LEU LEU GLU GLU GLU ILE          
SEQRES   2 F  159  PRO GLY GLY ARG ARG ALA LEU PHE ASP SER TYR THR ASN          
SEQRES   3 F  159  LEU GLU ARG VAL ALA ASP TYR CYS GLU ASN ASN TYR ILE          
SEQRES   4 F  159  GLN SER ALA ASP LYS GLN ARG ALA LEU GLU GLU THR LYS          
SEQRES   5 F  159  ALA TYR THR THR GLN SER LEU ALA SER VAL ALA TYR LEU          
SEQRES   6 F  159  ILE ASN THR LEU ALA ASN ASN VAL LEU GLN MET LEU ASP          
SEQRES   7 F  159  ILE GLN ALA SER GLN LEU ARG ARG MET GLU SER SER ILE          
SEQRES   8 F  159  ASN HIS ILE SER GLN THR VAL ASP ILE HIS LYS GLU LYS          
SEQRES   9 F  159  VAL ALA ARG ARG GLU ILE GLY ILE LEU THR THR ASN LYS          
SEQRES  10 F  159  ASN THR SER ARG THR HIS LYS ILE ILE ALA PRO ALA ASN          
SEQRES  11 F  159  LEU GLU ARG PRO VAL ARG TYR ILE ARG LYS PRO ILE ASP          
SEQRES  12 F  159  TYR THR ILE LEU ASP ASP ILE GLY HIS GLY VAL LYS VAL          
SEQRES  13 F  159  SER THR GLN                                                  
HET    TRS  A1254       8                                                       
HET     CL  A1255       1                                                       
HET     CL  A1256       1                                                       
HET     CL  A1257       1                                                       
HET     CL  A1258       1                                                       
HET    GOL  A1259       6                                                       
HET    GOL  A1260       6                                                       
HET    GOL  A1261       6                                                       
HET     CL  B1129       1                                                       
HET     CL  B1130       1                                                       
HET     CL  B1131       1                                                       
HET    GOL  B1132       6                                                       
HETNAM     TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL                         
HETNAM      CL CHLORIDE ION                                                     
HETNAM     GOL GLYCEROL                                                         
HETSYN     TRS TRIS BUFFER                                                      
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL                                    
FORMUL   6  TRS    C4 H12 N O3 1+                                               
FORMUL   7   CL    7(CL 1-)                                                     
FORMUL  11  GOL    4(C3 H8 O3)                                                  
FORMUL  18  HOH   *957(H2 O)                                                    
HELIX    1   1 THR A    6  GLU A   18  1                                  13    
HELIX    2   2 ARG A   58  THR A   85  1                                  28    
HELIX    3   3 CYS A   89  ILE A   93  5                                   5    
HELIX    4   4 ASN A  103  CYS A  144  1                                  42    
HELIX    5   5 GLU A  147  ASP A  151  5                                   5    
HELIX    6   6 SER A  154  LYS A  178  1                                  25    
HELIX    7   7 LYS A  178  PHE A  194  1                                  17    
HELIX    8   8 ASP A  200  ASN A  216  1                                  17    
HELIX    9   9 ASN A  218  VAL A  230  1                                  13    
HELIX   10  10 GLY A  233  ASN A  251  1                                  19    
HELIX   11  11 THR A  256  ASP A  275  1                                  20    
HELIX   12  12 ASN A  280  LYS A  287  1                                   8    
HELIX   13  13 ASN A  291  LEU A  302  1                                  12    
HELIX   14  14 LEU A  315  THR A  321  1                                   7    
HELIX   15  15 TYR A  325  TRP A  332  5                                   8    
HELIX   16  16 ILE A  345  TYR A  366  1                                  22    
HELIX   17  17 THR A  383  HIS A  418  1                                  36    
HELIX   18  18 GLU A  433  THR A  439  1                                   7    
HELIX   19  19 ARG A  440  TYR A  443  5                                   4    
HELIX   20  20 THR A  444  MET A  468  1                                  25    
HELIX   21  21 MET A  468  VAL A  490  1                                  23    
HELIX   22  22 LEU A  492  LYS A  502  1                                  11    
HELIX   23  23 LYS A  504  CYS A  519  1                                  16    
HELIX   24  24 ASP A  530  GLY A  535  1                                   6    
HELIX   25  25 SER A  555  ALA A  571  1                                  17    
HELIX   26  26 GLU A  585  SER A  599  1                                  15    
HELIX   27  27 PHE A  601  ASN A  607  1                                   7    
HELIX   28  28 ASN A  607  CYS A  616  1                                  10    
HELIX   29  29 LEU A  618  TRP A  622  5                                   5    
HELIX   30  30 ARG A  624  THR A  631  1                                   8    
HELIX   31  31 PRO A  639  MET A  642  5                                   4    
HELIX   32  32 SER A  643  LYS A  656  1                                  14    
HELIX   33  33 GLU A  657  MET A  661  5                                   5    
HELIX   34  34 TYR A  663  ASP A  669  1                                   7    
HELIX   35  35 ASP A  669  ARG A  681  1                                  13    
HELIX   36  36 LYS A  684  LEU A  722  1                                  39    
HELIX   37  37 ASP A  724  GLN A  734  1                                  11    
HELIX   38  38 TYR A  746  LYS A  751  1                                   6    
HELIX   39  39 ASP A  763  SER A  789  1                                  27    
HELIX   40  40 GLU A  790  THR A  793  5                                   4    
HELIX   41  41 SER A  794  ARG A  814  1                                  21    
HELIX   42  42 GLY A  820  ASN A  829  1                                  10    
HELIX   43  43 GLY A  837  ASP A  850  1                                  14    
HELIX   44  44 ASP A  850  ASN A  854  1                                   5    
HELIX   45  45 VAL A  868  SER A  872  5                                   5    
HELIX   46  46 GLN A  884  LEU A  888  5                                   5    
HELIX   47  47 SER A  891  TYR A  902  1                                  12    
HELIX   48  48 GLY A  903  ASN A  907  5                                   5    
HELIX   49  49 GLY A  910  GLY A  943  1                                  34    
HELIX   50  50 GLY A  943  MET A  956  1                                  14    
HELIX   51  51 ARG A  964  TYR A  967  5                                   4    
HELIX   52  52 GLY A  968  LEU A  980  1                                  13    
HELIX   53  53 LEU A  980  GLU A  985  1                                   6    
HELIX   54  54 VAL A  992  ALA A 1026  1                                  35    
HELIX   55  55 PRO A 1027  ASN A 1030  5                                   4    
HELIX   56  56 ARG A 1042  TYR A 1054  1                                  13    
HELIX   57  57 ALA A 1055  LEU A 1057  5                                   3    
HELIX   58  58 HIS A 1058  GLY A 1067  1                                  10    
HELIX   59  59 THR A 1068  GLU A 1084  1                                  17    
HELIX   60  60 ARG A 1085  CYS A 1088  5                                   4    
HELIX   61  61 MET A 1092  SER A 1102  1                                  11    
HELIX   62  62 GLU A 1126  ILE A 1140  1                                  15    
HELIX   63  63 THR A 1148  GLY A 1154  1                                   7    
HELIX   64  64 ASP A 1155  LEU A 1168  1                                  14    
HELIX   65  65 GLN A 1170  ASP A 1178  1                                   9    
HELIX   66  66 ASP A 1178  GLY A 1191  1                                  14    
HELIX   67  67 LEU A 1201  LEU A 1226  1                                  26    
HELIX   68  68 GLN B    7  GLN B   11  5                                   5    
HELIX   69  69 LYS B   12  ASP B   40  1                                  29    
HELIX   70  70 PRO B   45  ILE B   49  5                                   5    
HELIX   71  71 LEU B   53  PHE B   64  1                                  12    
HELIX   72  72 LEU B   76  GLU B   82  1                                   7    
HELIX   73  73 GLU B   82  GLN B  118  1                                  37    
HELIX   74  74 ASN B  126  ARG B  149  1                                  24    
HELIX   75  75 GLU B  152  MET B  166  1                                  15    
HELIX   76  76 GLU B  174  TYR B  185  1                                  12    
HELIX   77  77 ASN B  187  PHE B  196  1                                  10    
HELIX   78  78 HIS B  199  SER B  209  1                                  11    
HELIX   79  79 LEU B  210  MET B  212  5                                   3    
HELIX   80  80 VAL B  213  ASN B  218  1                                   6    
HELIX   81  81 SER B  220  ALA B  227  1                                   8    
HELIX   82  82 ALA B  235  MET B  239  5                                   5    
HELIX   83  83 THR B  247  LEU B  253  1                                   7    
HELIX   84  84 SER B  254  CYS B  269  1                                  16    
HELIX   85  85 HIS B  270  ASP B  276  1                                   7    
HELIX   86  86 ASP B  276  GLN B  288  1                                  13    
HELIX   87  87 ILE B  303  VAL B  312  1                                  10    
HELIX   88  88 ASN B  313  ASN B  318  5                                   6    
HELIX   89  89 LYS B  319  GLN B  360  1                                  42    
HELIX   90  90 PRO B  361  GLY B  365  5                                   5    
HELIX   91  91 LYS B  367  MET B  392  1                                  26    
HELIX   92  92 HIS B  404  TYR B  422  1                                  19    
HELIX   93  93 TYR B  422  PHE B  437  1                                  16    
HELIX   94  94 PHE B  437  GLN B  447  1                                  11    
HELIX   95  95 PRO B  453  SER B  469  1                                  17    
HELIX   96  96 SER B  471  ASP B  477  1                                   7    
HELIX   97  97 PHE B  483  VAL B  499  1                                  17    
HELIX   98  98 GLY B  505  ASP B  508  5                                   4    
HELIX   99  99 HIS B  509  SER B  528  1                                  20    
HELIX  100 100 SER B  528  ASP B  538  1                                  11    
HELIX  101 101 LEU B  539  PHE B  544  5                                   6    
HELIX  102 102 TYR B  545  LEU B  559  1                                  15    
HELIX  103 103 LEU B  559  ARG B  564  1                                   6    
HELIX  104 104 ILE B  567  CYS B  573  1                                   7    
HELIX  105 105 THR B  574  THR B  580  5                                   7    
HELIX  106 106 CYS B  584  GLU B  586  5                                   3    
HELIX  107 107 GLU B  587  GLN B  627  1                                  41    
HELIX  108 108 LEU B  628  HIS B  632  5                                   5    
HELIX  109 109 CYS B  633  VAL B  641  1                                   9    
HELIX  110 110 GLY B  661  MET B  665  5                                   5    
HELIX  111 111 THR B  673  ASN B  690  1                                  18    
HELIX  112 112 THR B  703  THR B  724  1                                  22    
HELIX  113 113 LYS B  735  ILE B  753  1                                  19    
HELIX  114 114 GLU B  754  TYR B  756  5                                   3    
HELIX  115 115 ASP B  760  GLN B  772  1                                  13    
HELIX  116 116 THR B  783  THR B  795  1                                  13    
HELIX  117 117 THR B  795  ASN B  802  1                                   8    
HELIX  118 118 ALA B  827  ASP B  832  1                                   6    
HELIX  119 119 ASP B  832  GLU B  872  1                                  41    
HELIX  120 120 ASN B  873  SER B  883  1                                  11    
HELIX  121 121 LYS B  886  LYS B  895  1                                  10    
HELIX  122 122 SER B  899  ILE B  932  1                                  34    
HELIX  123 123 ILE B  932  HIS B  945  1                                  14    
HELIX  124 124 VAL B  954  ALA B  965  1                                  12    
HELIX  125 125 ASP B  972  SER B  980  1                                   9    
HELIX  126 126 SER B  988  LEU B 1007  1                                  20    
HELIX  127 127 PRO B 1008  SER B 1016  5                                   9    
HELIX  128 128 ASN B 1028  HIS B 1030  5                                   3    
HELIX  129 129 CYS B 1031  HIS B 1047  1                                  17    
HELIX  130 130 SER B 1050  ILE B 1069  1                                  20    
HELIX  131 131 ASN B 1080  SER B 1095  1                                  16    
HELIX  132 132 THR B 1099  PHE B 1107  1                                   9    
HELIX  133 133 PRO B 1108  LYS B 1121  1                                  14    
HELIX  134 134 GLU D   25  GLN D   82  1                                  58    
HELIX  135 135 LEU D   92  MET D   97  1                                   6    
HELIX  136 136 ASP D  113  LEU D  117  5                                   5    
HELIX  137 137 PRO D  118  CYS D  128  1                                  11    
HELIX  138 138 PRO D  133  ARG D  141  5                                   9    
HELIX  139 139 GLU D  146  TYR D  151  5                                   6    
HELIX  140 140 SER D  155  LYS D  182  1                                  28    
HELIX  141 142 ASP D  250  VAL D  261  1                                  12    
HELIX  142 143 ARG E   10  THR E   69  1                                  60    
HELIX  143 144 ALA F    0  GLU F   10  1                                  11    
HELIX  144 145 GLU F   10  SER F   40  1                                  31    
HELIX  145 146 ASP F   42  ILE F  111  1                                  70    
SHEET    1   A 2 VAL A 304  PHE A 308  0                                        
SHEET    2   A 2 MET A 311  GLU A 314 -1  O  ILE A 313   N  VAL A 305           
SHEET    1   B 2 VAL A 755  LEU A 757  0                                        
SHEET    2   B 2 ARG A 760  ILE A 762 -1  O  ILE A 762   N  VAL A 755           
SHEET    1   C 2 TYR A 855  ASN A 858  0                                        
SHEET    2   C 2 ARG A 863  ARG A 866 -1  O  VAL A 865   N  CYS A 856           
SHEET    1   D 2 LEU A1090  SER A1091  0                                        
SHEET    2   D 2 THR F 114  ASN F 115 -1  O  THR F 114   N  SER A1091           
SHEET    1   E 2 ILE A1195  ILE A1196  0                                        
SHEET    2   E 2 VAL A1199  PRO A1200 -1  O  VAL A1199   N  ILE A1196           
SHEET    1   F 2 CYS B 292  PHE B 296  0                                        
SHEET    2   F 2 GLU B 299  HIS B 302 -1  O  PHE B 301   N  LEU B 293           
SHEET    1   G 3 MET B 695  VAL B 697  0                                        
SHEET    2   G 3 HIS B 700  PHE B 702 -1  O  PHE B 702   N  MET B 695           
SHEET    3   G 3 ILE F 124  ILE F 125 -1  O  ILE F 125   N  THR B 701           
SHEET    1   H 2 ILE B 805  PHE B 808  0                                        
SHEET    2   H 2 ALA B 813  ASN B 816 -1  O  ALA B 813   N  PHE B 808           
SHEET    1   I 2 TYR B1018  SER B1019  0                                        
SHEET    2   I 2 GLY B1024  HIS B1025 -1  O  GLY B1024   N  SER B1019           
CISPEP   1 PHE B   64    PRO B   65          0         4.04                     
SITE     1 AC1  4 TYR A 967  PHE A 975  HOH A1662  HOH A1663                    
SITE     1 AC2  2 ARG A 786  GLU A 797                                          
SITE     1 AC3  5 GLU A 173  THR A 221  ARG A 317  TYR A 318                    
SITE     2 AC3  5 THR A 321                                                     
SITE     1 AC4  2 ASP A 689  TYR D 125                                          
SITE     1 AC5  6 THR A 769  GLN A 770  THR A 817  HOH A1311                    
SITE     2 AC5  6 HOH A1447  ARG E  59                                          
SITE     1 AC6  1 HIS B 590                                                     
SITE     1 AC7  4 ARG B 340  ARG B 343  PHE B 400  HOH B1133                    
SITE     1 AC8  2 HIS B 700  ILE F 124                                          
CRYST1   97.013  113.982  327.193  90.00  90.00  90.00 P 21 21 21    4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010308  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.008773  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003056        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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