GenomeNet

Database: PDB
Entry: 4D61
LinkDB: 4D61
Original site: 4D61 
HEADER    RIBOSOME                                07-NOV-14   4D61              
TITLE     CRYO-EM STRUCTURES OF RIBOSOMAL 80S COMPLEXES WITH TERMINATION FACTORS
TITLE    2 AND CRICKET PARALYSIS VIRUS IRES REVEAL THE IRES IN THE TRANSLOCATED 
TITLE    3 STATE                                                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 18S RRNA;                                                  
COMPND   3 CHAIN: 1;                                                            
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: 40S RIBOSOMAL PROTEIN SA;                                  
COMPND   6 CHAIN: A;                                                            
COMPND   7 SYNONYM: 40S RIBOSOMAL PROTEIN US2,37 KDA LAMININ RECEPTOR PRECURSOR,
COMPND   8 37LRP, 37/67 KDA LAMININ RECEPTOR, LRP/LR, 67 KDA LAMININ RECEPTOR,  
COMPND   9 67LR, COLON CARCINOMA LAMININ-BINDING PROTEIN, LAMININ RECEPTOR 1,   
COMPND  10 LAMR, LAMININ-BINDING PROTEIN PRECURSOR P40, LBP/P40, MULTIDRUG      
COMPND  11 RESISTANCE-ASSOCIATED PROTEIN MGR1-AG, NEM/1CHD4;                    
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;                                 
COMPND  14 CHAIN: B;                                                            
COMPND  15 SYNONYM: 40S RIBOSOMAL PROTEIN ES1, V-FOS TRANSFORMATION EFFECTOR    
COMPND  16 PROTEIN, FTE-1;                                                      
COMPND  17 MOL_ID: 4;                                                           
COMPND  18 MOLECULE: 40S RIBOSOMAL PROTEIN S2;                                  
COMPND  19 CHAIN: C;                                                            
COMPND  20 SYNONYM: 40S RIBOSOMAL PROTEIN US5, PROTEIN LLREP3;                  
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: 40S RIBOSOMAL PROTEIN S3;                                  
COMPND  23 CHAIN: D;                                                            
COMPND  24 SYNONYM: 40S RIBOSOMAL PROTEIN US3;                                  
COMPND  25 MOL_ID: 6;                                                           
COMPND  26 MOLECULE: 40S RIBOSOMAL PROTEIN S4, Y ISOFORM 1;                     
COMPND  27 CHAIN: E;                                                            
COMPND  28 SYNONYM: 40S RIBOSOMAL PROTEIN ES4;                                  
COMPND  29 MOL_ID: 7;                                                           
COMPND  30 MOLECULE: 40S RIBOSOMAL PROTEIN S5;                                  
COMPND  31 CHAIN: F;                                                            
COMPND  32 SYNONYM: 40S RIBOSOMAL PROTEIN US7;                                  
COMPND  33 MOL_ID: 8;                                                           
COMPND  34 MOLECULE: 40S RIBOSOMAL PROTEIN S6;                                  
COMPND  35 CHAIN: G;                                                            
COMPND  36 SYNONYM: 40S RIBOSOMAL PROTEIN ES6, PHOSPHOPROTEIN NP33;             
COMPND  37 MOL_ID: 9;                                                           
COMPND  38 MOLECULE: 40S RIBOSOMAL PROTEIN S7;                                  
COMPND  39 CHAIN: H;                                                            
COMPND  40 SYNONYM: 40S RIBOSOMAL PROTEIN ES7;                                  
COMPND  41 MOL_ID: 10;                                                          
COMPND  42 MOLECULE: 40S RIBOSOMAL PROTEIN S8;                                  
COMPND  43 CHAIN: I;                                                            
COMPND  44 SYNONYM: 40S RIBOSOMAL PROTEIN ES8;                                  
COMPND  45 MOL_ID: 11;                                                          
COMPND  46 MOLECULE: 40S RIBOSOMAL PROTEIN S9;                                  
COMPND  47 CHAIN: J;                                                            
COMPND  48 SYNONYM: 40S RIBOSOMAL PROTEIN US4;                                  
COMPND  49 MOL_ID: 12;                                                          
COMPND  50 MOLECULE: 40S RIBOSOMAL PROTEIN S10;                                 
COMPND  51 CHAIN: K;                                                            
COMPND  52 SYNONYM: 40S RIBOSOMAL PROTEIN ES10;                                 
COMPND  53 MOL_ID: 13;                                                          
COMPND  54 MOLECULE: 40S RIBOSOMAL PROTEIN S11;                                 
COMPND  55 CHAIN: L;                                                            
COMPND  56 SYNONYM: 40S RIBOSOMAL PROTEIN US17;                                 
COMPND  57 MOL_ID: 14;                                                          
COMPND  58 MOLECULE: 40S RIBOSOMAL PROTEIN S12;                                 
COMPND  59 CHAIN: M;                                                            
COMPND  60 SYNONYM: 40S RIBOSOMAL PROTEIN ES12;                                 
COMPND  61 MOL_ID: 15;                                                          
COMPND  62 MOLECULE: 40S RIBOSOMAL PROTEIN S13;                                 
COMPND  63 CHAIN: N;                                                            
COMPND  64 SYNONYM: 40S RIBOSOMAL PROTEIN US15;                                 
COMPND  65 MOL_ID: 16;                                                          
COMPND  66 MOLECULE: 40S RIBOSOMAL PROTEIN S14;                                 
COMPND  67 CHAIN: O;                                                            
COMPND  68 SYNONYM: 40S RIBOSOMAL PROTEIN US11;                                 
COMPND  69 MOL_ID: 17;                                                          
COMPND  70 MOLECULE: 40S RIBOSOMAL PROTEIN S15;                                 
COMPND  71 CHAIN: P;                                                            
COMPND  72 SYNONYM: 40S RIBOSOMAL PROTEIN US19, RIG PROTEIN;                    
COMPND  73 MOL_ID: 18;                                                          
COMPND  74 MOLECULE: 40S RIBOSOMAL PROTEIN S16;                                 
COMPND  75 CHAIN: Q;                                                            
COMPND  76 SYNONYM: 40S RIBOSOMAL PROTEIN US9;                                  
COMPND  77 MOL_ID: 19;                                                          
COMPND  78 MOLECULE: 40S RIBOSOMAL PROTEIN S17;                                 
COMPND  79 CHAIN: R;                                                            
COMPND  80 SYNONYM: 40S RIBOSOMAL PROTEIN ES17;                                 
COMPND  81 MOL_ID: 20;                                                          
COMPND  82 MOLECULE: 40S RIBOSOMAL PROTEIN S18;                                 
COMPND  83 CHAIN: S;                                                            
COMPND  84 SYNONYM: 40S RIBOSOMAL PROTEIN US13, KE-3, KE3;                      
COMPND  85 MOL_ID: 21;                                                          
COMPND  86 MOLECULE: 40S RIBOSOMAL PROTEIN S19;                                 
COMPND  87 CHAIN: T;                                                            
COMPND  88 SYNONYM: 40S RIBOSOMAL PROTEIN ES19;                                 
COMPND  89 MOL_ID: 22;                                                          
COMPND  90 MOLECULE: 40S RIBOSOMAL PROTEIN S20;                                 
COMPND  91 CHAIN: U;                                                            
COMPND  92 SYNONYM: 40S RIBOSOMAL PROTEIN US10;                                 
COMPND  93 MOL_ID: 23;                                                          
COMPND  94 MOLECULE: 40S RIBOSOMAL PROTEIN S21;                                 
COMPND  95 CHAIN: V;                                                            
COMPND  96 SYNONYM: 40S RIBOSOMAL PROTEIN ES21;                                 
COMPND  97 MOL_ID: 24;                                                          
COMPND  98 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;                                
COMPND  99 CHAIN: W;                                                            
COMPND 100 SYNONYM: 40S RIBOSOMAL PROTEIN US8;                                  
COMPND 101 MOL_ID: 25;                                                          
COMPND 102 MOLECULE: 40S RIBOSOMAL PROTEIN S23;                                 
COMPND 103 CHAIN: X;                                                            
COMPND 104 SYNONYM: 40S RIBOSOMAL PROTEIN US12;                                 
COMPND 105 MOL_ID: 26;                                                          
COMPND 106 MOLECULE: 40S RIBOSOMAL PROTEIN S24;                                 
COMPND 107 CHAIN: Y;                                                            
COMPND 108 SYNONYM: 40S RIBOSOMAL PROTEIN ES24;                                 
COMPND 109 MOL_ID: 27;                                                          
COMPND 110 MOLECULE: 40S RIBOSOMAL PROTEIN S25;                                 
COMPND 111 CHAIN: Z;                                                            
COMPND 112 SYNONYM: 40S RIBOSOMAL PROTEIN ES25;                                 
COMPND 113 MOL_ID: 28;                                                          
COMPND 114 MOLECULE: 40S RIBOSOMAL PROTEIN S26;                                 
COMPND 115 CHAIN: a;                                                            
COMPND 116 SYNONYM: 40S RIBOSOMAL PROTEIN ES26;                                 
COMPND 117 MOL_ID: 29;                                                          
COMPND 118 MOLECULE: 40S RIBOSOMAL PROTEIN S27;                                 
COMPND 119 CHAIN: b;                                                            
COMPND 120 SYNONYM: 40S RIBOSOMAL PROTEIN ES27, METALLOPAN-STIMULIN 1, MPS-1;   
COMPND 121 MOL_ID: 30;                                                          
COMPND 122 MOLECULE: 40S RIBOSOMAL PROTEIN S28;                                 
COMPND 123 CHAIN: c;                                                            
COMPND 124 SYNONYM: 40S RIBOSOMAL PROTEIN ES28;                                 
COMPND 125 MOL_ID: 31;                                                          
COMPND 126 MOLECULE: 40S RIBOSOMAL PROTEIN S29;                                 
COMPND 127 CHAIN: d;                                                            
COMPND 128 SYNONYM: 40S RIBOSOMAL PROTEIN US14;                                 
COMPND 129 MOL_ID: 32;                                                          
COMPND 130 MOLECULE: 40S RIBOSOMAL PROTEIN S30;                                 
COMPND 131 CHAIN: e;                                                            
COMPND 132 SYNONYM: 40S RIBOSOMAL PROTEIN ES30;                                 
COMPND 133 MOL_ID: 33;                                                          
COMPND 134 MOLECULE: UBIQUITIN-40S RIBOSOMAL PROTEIN S27A;                      
COMPND 135 CHAIN: f;                                                            
COMPND 136 SYNONYM: 40S RIBOSOMAL PROTEIN ES31, UBIQUITIN CARBOXYL EXTENSION    
COMPND 137 PROTEIN 80;                                                          
COMPND 138 MOL_ID: 34;                                                          
COMPND 139 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1;  
COMPND 140 CHAIN: g;                                                            
COMPND 141 SYNONYM: CELL PROLIFERATION-INDUCING GENE 21 PROTEIN, GUANINE NUCLEO 
COMPND 142 TIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 12.3, HUMAN LUNG CA   
COMPND 143 NCER ONCOGENE 7 PROTEIN, HLC-7, RECEPTOR FOR ACTIVATED C KINASE, R   
COMPND 144 ECEPTOR OF ACTIVATED PROTEIN KINASE C 1, RACK1;                      
COMPND 145 MOL_ID: 35;                                                          
COMPND 146 MOLECULE: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1;         
COMPND 147 CHAIN: h;                                                            
COMPND 148 SYNONYM: EUKARYOTIC RELEASE FACTOR 1, ERF1, PROTEIN CL1, TB3-1,;     
COMPND 149 ENGINEERED: YES;                                                     
COMPND 150 MOL_ID: 36;                                                          
COMPND 151 MOLECULE: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT
COMPND 152 ERF3A;                                                               
COMPND 153 CHAIN: i;                                                            
COMPND 154 FRAGMENT: G-DOMAIN, UNP RESIDUES 210-635;                            
COMPND 155 SYNONYM: EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 3A, ERF3A,  
COMPND 156 G1 TO S PHASE TRANSITION PROTEIN 1 HOMOLOG;                          
COMPND 157 ENGINEERED: YES;                                                     
COMPND 158 MOL_ID: 37;                                                          
COMPND 159 MOLECULE: CRICKET PARALYSIS VIRUS IRES RNA;                          
COMPND 160 CHAIN: j;                                                            
COMPND 161 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   3 ORGANISM_COMMON: RABBIT;                                             
SOURCE   4 ORGANISM_TAXID: 9986;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE   7 ORGANISM_COMMON: RABBIT;                                             
SOURCE   8 ORGANISM_TAXID: 9986;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  11 ORGANISM_COMMON: RABBIT;                                             
SOURCE  12 ORGANISM_TAXID: 9986;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  15 ORGANISM_COMMON: RABBIT;                                             
SOURCE  16 ORGANISM_TAXID: 9986;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  19 ORGANISM_COMMON: RABBIT;                                             
SOURCE  20 ORGANISM_TAXID: 9986;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  23 ORGANISM_COMMON: RABBIT;                                             
SOURCE  24 ORGANISM_TAXID: 9986;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  27 ORGANISM_COMMON: RABBIT;                                             
SOURCE  28 ORGANISM_TAXID: 9986;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  31 ORGANISM_COMMON: RABBIT;                                             
SOURCE  32 ORGANISM_TAXID: 9986;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  35 ORGANISM_COMMON: RABBIT;                                             
SOURCE  36 ORGANISM_TAXID: 9986;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  39 ORGANISM_COMMON: RABBIT;                                             
SOURCE  40 ORGANISM_TAXID: 9986;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  43 ORGANISM_COMMON: RABBIT;                                             
SOURCE  44 ORGANISM_TAXID: 9986;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  47 ORGANISM_COMMON: RABBIT;                                             
SOURCE  48 ORGANISM_TAXID: 9986;                                                
SOURCE  49 MOL_ID: 13;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  51 ORGANISM_COMMON: RABBIT;                                             
SOURCE  52 ORGANISM_TAXID: 9986;                                                
SOURCE  53 MOL_ID: 14;                                                          
SOURCE  54 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  55 ORGANISM_COMMON: RABBIT;                                             
SOURCE  56 ORGANISM_TAXID: 9986;                                                
SOURCE  57 MOL_ID: 15;                                                          
SOURCE  58 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  59 ORGANISM_COMMON: RABBIT;                                             
SOURCE  60 ORGANISM_TAXID: 9986;                                                
SOURCE  61 MOL_ID: 16;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  63 ORGANISM_COMMON: RABBIT;                                             
SOURCE  64 ORGANISM_TAXID: 9986;                                                
SOURCE  65 MOL_ID: 17;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  67 ORGANISM_COMMON: RABBIT;                                             
SOURCE  68 ORGANISM_TAXID: 9986;                                                
SOURCE  69 MOL_ID: 18;                                                          
SOURCE  70 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  71 ORGANISM_COMMON: RABBIT;                                             
SOURCE  72 ORGANISM_TAXID: 9986;                                                
SOURCE  73 MOL_ID: 19;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  75 ORGANISM_COMMON: RABBIT;                                             
SOURCE  76 ORGANISM_TAXID: 9986;                                                
SOURCE  77 MOL_ID: 20;                                                          
SOURCE  78 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  79 ORGANISM_COMMON: RABBIT;                                             
SOURCE  80 ORGANISM_TAXID: 9986;                                                
SOURCE  81 MOL_ID: 21;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  83 ORGANISM_COMMON: RABBIT;                                             
SOURCE  84 ORGANISM_TAXID: 9986;                                                
SOURCE  85 MOL_ID: 22;                                                          
SOURCE  86 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  87 ORGANISM_COMMON: RABBIT;                                             
SOURCE  88 ORGANISM_TAXID: 9986;                                                
SOURCE  89 MOL_ID: 23;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  91 ORGANISM_COMMON: RABBIT;                                             
SOURCE  92 ORGANISM_TAXID: 9986;                                                
SOURCE  93 MOL_ID: 24;                                                          
SOURCE  94 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  95 ORGANISM_COMMON: RABBIT;                                             
SOURCE  96 ORGANISM_TAXID: 9986;                                                
SOURCE  97 MOL_ID: 25;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE  99 ORGANISM_COMMON: RABBIT;                                             
SOURCE 100 ORGANISM_TAXID: 9986;                                                
SOURCE 101 MOL_ID: 26;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 103 ORGANISM_COMMON: RABBIT;                                             
SOURCE 104 ORGANISM_TAXID: 9986;                                                
SOURCE 105 MOL_ID: 27;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 107 ORGANISM_COMMON: RABBIT;                                             
SOURCE 108 ORGANISM_TAXID: 9986;                                                
SOURCE 109 MOL_ID: 28;                                                          
SOURCE 110 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 111 ORGANISM_COMMON: RABBIT;                                             
SOURCE 112 ORGANISM_TAXID: 9986;                                                
SOURCE 113 MOL_ID: 29;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 115 ORGANISM_COMMON: RABBIT;                                             
SOURCE 116 ORGANISM_TAXID: 9986;                                                
SOURCE 117 MOL_ID: 30;                                                          
SOURCE 118 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 119 ORGANISM_COMMON: RABBIT;                                             
SOURCE 120 ORGANISM_TAXID: 9986;                                                
SOURCE 121 MOL_ID: 31;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 123 ORGANISM_COMMON: RABBIT;                                             
SOURCE 124 ORGANISM_TAXID: 9986;                                                
SOURCE 125 MOL_ID: 32;                                                          
SOURCE 126 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 127 ORGANISM_COMMON: RABBIT;                                             
SOURCE 128 ORGANISM_TAXID: 9986;                                                
SOURCE 129 MOL_ID: 33;                                                          
SOURCE 130 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 131 ORGANISM_COMMON: RABBIT;                                             
SOURCE 132 ORGANISM_TAXID: 9986;                                                
SOURCE 133 MOL_ID: 34;                                                          
SOURCE 134 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS;                          
SOURCE 135 ORGANISM_COMMON: RABBIT;                                             
SOURCE 136 ORGANISM_TAXID: 9986;                                                
SOURCE 137 MOL_ID: 35;                                                          
SOURCE 138 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 139 ORGANISM_COMMON: HUMAN;                                              
SOURCE 140 ORGANISM_TAXID: 9606;                                                
SOURCE 141 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 142 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE 143 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE 144 MOL_ID: 36;                                                          
SOURCE 145 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 146 ORGANISM_COMMON: HUMAN;                                              
SOURCE 147 ORGANISM_TAXID: 9606;                                                
SOURCE 148 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 149 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE 150 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE 151 MOL_ID: 37;                                                          
SOURCE 152 SYNTHETIC: YES;                                                      
SOURCE 153 ORGANISM_SCIENTIFIC: CRICKET PARALYSIS VIRUS;                        
SOURCE 154 ORGANISM_TAXID: 12136                                                
KEYWDS    CRPV IRES, RIBOSOME, TERMINATION, RELEASE FACTORS                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    M.MUHS,T.HILAL,T.MIELKE,M.A.SKABKIN,K.Y.SANBONMATSU,T.V.PESTOVA,      
AUTHOR   2 C.M.T.SPAHN                                                          
REVDAT   2   30-AUG-17 4D61    1       COMPND REMARK ATOM                       
REVDAT   1   04-MAR-15 4D61    0                                                
JRNL        AUTH   M.MUHS,T.HILAL,T.MIELKE,M.A.SKABKIN,K.Y.SANBONMATSU,         
JRNL        AUTH 2 T.V.PESTOVA,C.M.T.SPAHN                                      
JRNL        TITL   CRYO-EM OF RIBOSOMAL 80S COMPLEXES WITH TERMINATION FACTORS  
JRNL        TITL 2 REVEALS THE TRANSLOCATED CRICKET PARALYSIS VIRUS IRES.       
JRNL        REF    MOL.CELL                      V.  57   422 2015              
JRNL        REFN                   ISSN 1097-2765                               
JRNL        PMID   25601755                                                     
JRNL        DOI    10.1016/J.MOLCEL.2014.12.016                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    9.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : UCSF CHIMERA, SPARX, SPIDER               
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : METHOD--RIGID BODY, FLEXIBLE FIT                 
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.560                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 9.000                          
REMARK   3   NUMBER OF PARTICLES               : 64902                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: CROSS- -CORRELATION     
REMARK   3  DENSITIES WITH REFERENCE STRUCTURE                                  
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 4D61 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1290062240.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE                      
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CRICKET PARALYSIS VIRUS IRES      
REMARK 245                                    RNA BOUND TO MAMMALIAN 80S        
REMARK 245                                    RIBOSOME, ERF1 AND ERF3           
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 1.38                              
REMARK 245   SAMPLE SUPPORT DETAILS         : HOLEY CARBON                      
REMARK 245   SAMPLE VITRIFICATION DETAILS   : LIQUID ETHANE                     
REMARK 245   SAMPLE BUFFER                  : 20 MM TRIS PH 7.5, 100 MM KCL,    
REMARK 245                                    1 MM DTT, 8.5 MM MGCL2, 0.133     
REMARK 245                                    MM GTP, 2.33 MM GMPPNP            
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : MICROGRAPHS WERE SELECTED FOR     
REMARK 245  DRIFT AND ASTIGMATISM                                               
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 05-NOV-12                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : 77.00                          
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F20                 
REMARK 245   DETECTOR TYPE                     : TVIPS TEMCAM-F416 (4K X 4K)    
REMARK 245   MINIMUM DEFOCUS (NM)              : 2000.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 5000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 20.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 115000                         
REMARK 245   CALIBRATED MAGNIFICATION          : 194805                         
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : MICROGRAPHS WERE SELECTED      
REMARK 245  FOR DRIFT AND ASTIGMATISM                                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 37-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 1, A, B, C, D, E, F, G, H, I,         
REMARK 350                    AND CHAINS: J, K, L, M, N, O, P, Q, R,            
REMARK 350                    AND CHAINS: S, T, U, V, W, X, Y, Z, a, b,         
REMARK 350                    AND CHAINS: c, d, e, f, g, h, i, j                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       G 1   241                                                      
REMARK 465       U 1   242                                                      
REMARK 465       C 1   243                                                      
REMARK 465       A 1   244                                                      
REMARK 465       G 1   245                                                      
REMARK 465       C 1   246                                                      
REMARK 465       C 1   247                                                      
REMARK 465       C 1   248                                                      
REMARK 465       C 1   249                                                      
REMARK 465       U 1   250                                                      
REMARK 465       C 1   251                                                      
REMARK 465       U 1   252                                                      
REMARK 465       C 1   253                                                      
REMARK 465       C 1   254                                                      
REMARK 465       G 1   255                                                      
REMARK 465       G 1   256                                                      
REMARK 465       C 1   257                                                      
REMARK 465       C 1   258                                                      
REMARK 465       C 1   259                                                      
REMARK 465       C 1   260                                                      
REMARK 465       G 1   261                                                      
REMARK 465       G 1   262                                                      
REMARK 465       C 1   263                                                      
REMARK 465       C 1   264                                                      
REMARK 465       G 1   265                                                      
REMARK 465       G 1   266                                                      
REMARK 465       G 1   267                                                      
REMARK 465       G 1   268                                                      
REMARK 465       G 1   269                                                      
REMARK 465       G 1   270                                                      
REMARK 465       C 1   271                                                      
REMARK 465       G 1   272                                                      
REMARK 465       G 1   273                                                      
REMARK 465       G 1   274                                                      
REMARK 465       C 1   275                                                      
REMARK 465       G 1   276                                                      
REMARK 465       C 1   277                                                      
REMARK 465       C 1   278                                                      
REMARK 465       G 1   279                                                      
REMARK 465       G 1   280                                                      
REMARK 465       C 1   281                                                      
REMARK 465       G 1   282                                                      
REMARK 465       G 1   283                                                      
REMARK 465       C 1   284                                                      
REMARK 465       U 1   285                                                      
REMARK 465       U 1   286                                                      
REMARK 465       U 1   287                                                      
REMARK 465       G 1   288                                                      
REMARK 465       G 1   289                                                      
REMARK 465       U 1   290                                                      
REMARK 465       G 1   291                                                      
REMARK 465       A 1   292                                                      
REMARK 465       C 1   293                                                      
REMARK 465       U 1   294                                                      
REMARK 465       C 1   295                                                      
REMARK 465       G 1   697                                                      
REMARK 465       G 1   698                                                      
REMARK 465       C 1   699                                                      
REMARK 465       G 1   700                                                      
REMARK 465       G 1   701                                                      
REMARK 465       G 1   702                                                      
REMARK 465       C 1   703                                                      
REMARK 465       G 1   704                                                      
REMARK 465       G 1   705                                                      
REMARK 465       U 1   706                                                      
REMARK 465       C 1   707                                                      
REMARK 465       C 1   708                                                      
REMARK 465       G 1   709                                                      
REMARK 465       C 1   710                                                      
REMARK 465       C 1   711                                                      
REMARK 465       G 1   712                                                      
REMARK 465       C 1   713                                                      
REMARK 465       G 1   714                                                      
REMARK 465       A 1   715                                                      
REMARK 465       G 1   716                                                      
REMARK 465       G 1   717                                                      
REMARK 465       C 1   718                                                      
REMARK 465       G 1   719                                                      
REMARK 465       A 1   720                                                      
REMARK 465       G 1   721                                                      
REMARK 465       C 1   722                                                      
REMARK 465       C 1   723                                                      
REMARK 465       A 1   724                                                      
REMARK 465       C 1   725                                                      
REMARK 465       C 1   726                                                      
REMARK 465       G 1   727                                                      
REMARK 465       C 1   728                                                      
REMARK 465       C 1   729                                                      
REMARK 465       C 1   730                                                      
REMARK 465       G 1   731                                                      
REMARK 465       U 1   732                                                      
REMARK 465       C 1   733                                                      
REMARK 465       C 1   734                                                      
REMARK 465       C 1   735                                                      
REMARK 465       C 1   756                                                      
REMARK 465       C 1   757                                                      
REMARK 465       C 1   758                                                      
REMARK 465       C 1   759                                                      
REMARK 465       U 1   760                                                      
REMARK 465       C 1   761                                                      
REMARK 465       G 1   762                                                      
REMARK 465       A 1   763                                                      
REMARK 465       U 1   764                                                      
REMARK 465       G 1   765                                                      
REMARK 465       C 1   766                                                      
REMARK 465       U 1   767                                                      
REMARK 465       C 1   768                                                      
REMARK 465       U 1   769                                                      
REMARK 465       U 1   770                                                      
REMARK 465       A 1   771                                                      
REMARK 465       G 1   772                                                      
REMARK 465       C 1   773                                                      
REMARK 465       U 1   774                                                      
REMARK 465       G 1   775                                                      
REMARK 465       A 1   776                                                      
REMARK 465       G 1   777                                                      
REMARK 465       U 1   778                                                      
REMARK 465       G 1   779                                                      
REMARK 465       U 1   780                                                      
REMARK 465       C 1   781                                                      
REMARK 465       C 1   782                                                      
REMARK 465       C 1   783                                                      
REMARK 465       G 1   784                                                      
REMARK 465       C 1   785                                                      
REMARK 465       G 1   786                                                      
REMARK 465       G 1   787                                                      
REMARK 465       G 1   788                                                      
REMARK 465     MET A     1                                                      
REMARK 465     LYS A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     VAL A   222                                                      
REMARK 465     THR A   223                                                      
REMARK 465     LYS A   224                                                      
REMARK 465     GLU A   225                                                      
REMARK 465     GLU A   226                                                      
REMARK 465     PHE A   227                                                      
REMARK 465     GLN A   228                                                      
REMARK 465     GLY A   229                                                      
REMARK 465     GLU A   230                                                      
REMARK 465     TRP A   231                                                      
REMARK 465     THR A   232                                                      
REMARK 465     ALA A   233                                                      
REMARK 465     PRO A   234                                                      
REMARK 465     ALA A   235                                                      
REMARK 465     PRO A   236                                                      
REMARK 465     GLU A   237                                                      
REMARK 465     PHE A   238                                                      
REMARK 465     THR A   239                                                      
REMARK 465     ALA A   240                                                      
REMARK 465     THR A   241                                                      
REMARK 465     GLN A   242                                                      
REMARK 465     PRO A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     VAL A   245                                                      
REMARK 465     ALA A   246                                                      
REMARK 465     ASP A   247                                                      
REMARK 465     TRP A   248                                                      
REMARK 465     SER A   249                                                      
REMARK 465     GLU A   250                                                      
REMARK 465     GLY A   251                                                      
REMARK 465     VAL A   252                                                      
REMARK 465     GLN A   253                                                      
REMARK 465     VAL A   254                                                      
REMARK 465     PRO A   255                                                      
REMARK 465     SER A   256                                                      
REMARK 465     VAL A   257                                                      
REMARK 465     PRO A   258                                                      
REMARK 465     ILE A   259                                                      
REMARK 465     GLN A   260                                                      
REMARK 465     GLN A   261                                                      
REMARK 465     PHE A   262                                                      
REMARK 465     PRO A   263                                                      
REMARK 465     THR A   264                                                      
REMARK 465     GLU A   265                                                      
REMARK 465     ASP A   266                                                      
REMARK 465     TRP A   267                                                      
REMARK 465     SER A   268                                                      
REMARK 465     ALA A   269                                                      
REMARK 465     GLN A   270                                                      
REMARK 465     PRO A   271                                                      
REMARK 465     ALA A   272                                                      
REMARK 465     THR A   273                                                      
REMARK 465     GLU A   274                                                      
REMARK 465     ASP A   275                                                      
REMARK 465     TRP A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     ALA A   279                                                      
REMARK 465     PRO A   280                                                      
REMARK 465     THR A   281                                                      
REMARK 465     ALA A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ALA A   284                                                      
REMARK 465     THR A   285                                                      
REMARK 465     GLU A   286                                                      
REMARK 465     TRP A   287                                                      
REMARK 465     VAL A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     ALA A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     THR A   292                                                      
REMARK 465     ASP A   293                                                      
REMARK 465     TRP A   294                                                      
REMARK 465     SER A   295                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     THR B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     LYS B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     ALA B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     LYS B    19                                                      
REMARK 465     LYS B    20                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     GLY B   235                                                      
REMARK 465     SER B   236                                                      
REMARK 465     SER B   237                                                      
REMARK 465     SER B   238                                                      
REMARK 465     GLY B   239                                                      
REMARK 465     LYS B   240                                                      
REMARK 465     ALA B   241                                                      
REMARK 465     THR B   242                                                      
REMARK 465     GLY B   243                                                      
REMARK 465     ASP B   244                                                      
REMARK 465     GLU B   245                                                      
REMARK 465     THR B   246                                                      
REMARK 465     GLY B   247                                                      
REMARK 465     ALA B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     ARG B   252                                                      
REMARK 465     ALA B   253                                                      
REMARK 465     ASP B   254                                                      
REMARK 465     GLY B   255                                                      
REMARK 465     TYR B   256                                                      
REMARK 465     GLU B   257                                                      
REMARK 465     PRO B   258                                                      
REMARK 465     PRO B   259                                                      
REMARK 465     VAL B   260                                                      
REMARK 465     GLN B   261                                                      
REMARK 465     GLU B   262                                                      
REMARK 465     SER B   263                                                      
REMARK 465     VAL B   264                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ALA C     7                                                      
REMARK 465     ALA C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     PRO C    11                                                      
REMARK 465     GLY C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     PRO C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     PRO C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     MET C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     ASN C    21                                                      
REMARK 465     ARG C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     GLY C    24                                                      
REMARK 465     PHE C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     GLY C    28                                                      
REMARK 465     PHE C    29                                                      
REMARK 465     GLY C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     GLY C    32                                                      
REMARK 465     ILE C    33                                                      
REMARK 465     ARG C    34                                                      
REMARK 465     GLY C    35                                                      
REMARK 465     ARG C    36                                                      
REMARK 465     GLY C    37                                                      
REMARK 465     ARG C    38                                                      
REMARK 465     GLY C    39                                                      
REMARK 465     ARG C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     ARG C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     ARG C    44                                                      
REMARK 465     GLY C    45                                                      
REMARK 465     ARG C    46                                                      
REMARK 465     GLY C    47                                                      
REMARK 465     ARG C    48                                                      
REMARK 465     GLY C    49                                                      
REMARK 465     ALA C    50                                                      
REMARK 465     ARG C    51                                                      
REMARK 465     GLY C    52                                                      
REMARK 465     GLY C    53                                                      
REMARK 465     LYS C    54                                                      
REMARK 465     ALA C    55                                                      
REMARK 465     GLU C    56                                                      
REMARK 465     ARG C   279                                                      
REMARK 465     VAL C   280                                                      
REMARK 465     SER C   281                                                      
REMARK 465     VAL C   282                                                      
REMARK 465     GLN C   283                                                      
REMARK 465     ARG C   284                                                      
REMARK 465     THR C   285                                                      
REMARK 465     GLN C   286                                                      
REMARK 465     ALA C   287                                                      
REMARK 465     PRO C   288                                                      
REMARK 465     ALA C   289                                                      
REMARK 465     VAL C   290                                                      
REMARK 465     ALA C   291                                                      
REMARK 465     THR C   292                                                      
REMARK 465     THR C   293                                                      
REMARK 465     MET D     1                                                      
REMARK 465     LYS D   214                                                      
REMARK 465     ASP D   215                                                      
REMARK 465     GLU D   216                                                      
REMARK 465     ILE D   217                                                      
REMARK 465     LEU D   218                                                      
REMARK 465     PRO D   219                                                      
REMARK 465     THR D   220                                                      
REMARK 465     THR D   221                                                      
REMARK 465     PRO D   222                                                      
REMARK 465     ILE D   223                                                      
REMARK 465     SER D   224                                                      
REMARK 465     GLU D   225                                                      
REMARK 465     GLN D   226                                                      
REMARK 465     LYS D   227                                                      
REMARK 465     GLY D   228                                                      
REMARK 465     GLY D   229                                                      
REMARK 465     LYS D   230                                                      
REMARK 465     PRO D   231                                                      
REMARK 465     GLU D   232                                                      
REMARK 465     PRO D   233                                                      
REMARK 465     PRO D   234                                                      
REMARK 465     ALA D   235                                                      
REMARK 465     MET D   236                                                      
REMARK 465     PRO D   237                                                      
REMARK 465     GLN D   238                                                      
REMARK 465     PRO D   239                                                      
REMARK 465     VAL D   240                                                      
REMARK 465     PRO D   241                                                      
REMARK 465     THR D   242                                                      
REMARK 465     ALA D   243                                                      
REMARK 465     MET E     1                                                      
REMARK 465     LYS E   259                                                      
REMARK 465     GLN E   260                                                      
REMARK 465     SER E   261                                                      
REMARK 465     SER E   262                                                      
REMARK 465     GLY E   263                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     TRP F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     THR F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     PRO F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     GLU F    13                                                      
REMARK 465     THR F    14                                                      
REMARK 465     PRO F    15                                                      
REMARK 465     ASP F    16                                                      
REMARK 465     ARG G   233                                                      
REMARK 465     LEU G   234                                                      
REMARK 465     SER G   235                                                      
REMARK 465     SER G   236                                                      
REMARK 465     LEU G   237                                                      
REMARK 465     ARG G   238                                                      
REMARK 465     ALA G   239                                                      
REMARK 465     SER G   240                                                      
REMARK 465     THR G   241                                                      
REMARK 465     SER G   242                                                      
REMARK 465     LYS G   243                                                      
REMARK 465     SER G   244                                                      
REMARK 465     GLU G   245                                                      
REMARK 465     SER G   246                                                      
REMARK 465     SER G   247                                                      
REMARK 465     GLN G   248                                                      
REMARK 465     LYS G   249                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PHE H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     MET I     1                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLY J   181                                                      
REMARK 465     GLN J   182                                                      
REMARK 465     GLY J   183                                                      
REMARK 465     GLY J   184                                                      
REMARK 465     ALA J   185                                                      
REMARK 465     GLY J   186                                                      
REMARK 465     ALA J   187                                                      
REMARK 465     GLY J   188                                                      
REMARK 465     ASP J   189                                                      
REMARK 465     ASP J   190                                                      
REMARK 465     GLU J   191                                                      
REMARK 465     GLU J   192                                                      
REMARK 465     GLU J   193                                                      
REMARK 465     ASP J   194                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ARG K    96                                                      
REMARK 465     SER K    97                                                      
REMARK 465     ARG K    98                                                      
REMARK 465     PRO K    99                                                      
REMARK 465     GLU K   100                                                      
REMARK 465     THR K   101                                                      
REMARK 465     GLY K   102                                                      
REMARK 465     ARG K   103                                                      
REMARK 465     PRO K   104                                                      
REMARK 465     ARG K   105                                                      
REMARK 465     PRO K   106                                                      
REMARK 465     LYS K   107                                                      
REMARK 465     GLY K   108                                                      
REMARK 465     LEU K   109                                                      
REMARK 465     GLU K   110                                                      
REMARK 465     GLY K   111                                                      
REMARK 465     GLU K   112                                                      
REMARK 465     ARG K   113                                                      
REMARK 465     PRO K   114                                                      
REMARK 465     ALA K   115                                                      
REMARK 465     ARG K   116                                                      
REMARK 465     LEU K   117                                                      
REMARK 465     THR K   118                                                      
REMARK 465     ARG K   119                                                      
REMARK 465     GLY K   120                                                      
REMARK 465     GLU K   121                                                      
REMARK 465     ALA K   122                                                      
REMARK 465     ASP K   123                                                      
REMARK 465     ARG K   124                                                      
REMARK 465     ASP K   125                                                      
REMARK 465     THR K   126                                                      
REMARK 465     TYR K   127                                                      
REMARK 465     ARG K   128                                                      
REMARK 465     ARG K   129                                                      
REMARK 465     SER K   130                                                      
REMARK 465     ALA K   131                                                      
REMARK 465     VAL K   132                                                      
REMARK 465     PRO K   133                                                      
REMARK 465     PRO K   134                                                      
REMARK 465     GLY K   135                                                      
REMARK 465     ALA K   136                                                      
REMARK 465     ASP K   137                                                      
REMARK 465     LYS K   138                                                      
REMARK 465     LYS K   139                                                      
REMARK 465     ALA K   140                                                      
REMARK 465     GLU K   141                                                      
REMARK 465     ALA K   142                                                      
REMARK 465     GLY K   143                                                      
REMARK 465     ALA K   144                                                      
REMARK 465     GLY K   145                                                      
REMARK 465     SER K   146                                                      
REMARK 465     ALA K   147                                                      
REMARK 465     THR K   148                                                      
REMARK 465     GLU K   149                                                      
REMARK 465     PHE K   150                                                      
REMARK 465     GLN K   151                                                      
REMARK 465     PHE K   152                                                      
REMARK 465     ARG K   153                                                      
REMARK 465     GLY K   154                                                      
REMARK 465     GLY K   155                                                      
REMARK 465     PHE K   156                                                      
REMARK 465     GLY K   157                                                      
REMARK 465     ARG K   158                                                      
REMARK 465     GLY K   159                                                      
REMARK 465     ARG K   160                                                      
REMARK 465     GLY K   161                                                      
REMARK 465     GLN K   162                                                      
REMARK 465     PRO K   163                                                      
REMARK 465     PRO K   164                                                      
REMARK 465     GLN K   165                                                      
REMARK 465     MET L     1                                                      
REMARK 465     ALA L   148                                                      
REMARK 465     ALA L   149                                                      
REMARK 465     GLY L   150                                                      
REMARK 465     THR L   151                                                      
REMARK 465     LYS L   152                                                      
REMARK 465     LYS L   153                                                      
REMARK 465     GLN L   154                                                      
REMARK 465     PHE L   155                                                      
REMARK 465     GLN L   156                                                      
REMARK 465     LYS L   157                                                      
REMARK 465     PHE L   158                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     GLU M     3                                                      
REMARK 465     GLU M     4                                                      
REMARK 465     GLY M     5                                                      
REMARK 465     ILE M     6                                                      
REMARK 465     ALA M     7                                                      
REMARK 465     ALA M     8                                                      
REMARK 465     GLY M     9                                                      
REMARK 465     GLY M    10                                                      
REMARK 465     LYS M   131                                                      
REMARK 465     LYS M   132                                                      
REMARK 465     MET N     1                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     PRO O     3                                                      
REMARK 465     ARG O     4                                                      
REMARK 465     LYS O     5                                                      
REMARK 465     GLY O     6                                                      
REMARK 465     LYS O     7                                                      
REMARK 465     GLU O     8                                                      
REMARK 465     LYS O     9                                                      
REMARK 465     LYS O    10                                                      
REMARK 465     GLU O    11                                                      
REMARK 465     GLU O    12                                                      
REMARK 465     GLN O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     VAL P     4                                                      
REMARK 465     GLU P     5                                                      
REMARK 465     GLN P     6                                                      
REMARK 465     LYS P     7                                                      
REMARK 465     LYS P     8                                                      
REMARK 465     LYS P     9                                                      
REMARK 465     ARG P    10                                                      
REMARK 465     THR P    11                                                      
REMARK 465     ARG P   130                                                      
REMARK 465     PRO P   131                                                      
REMARK 465     GLY P   132                                                      
REMARK 465     ILE P   133                                                      
REMARK 465     GLY P   134                                                      
REMARK 465     ALA P   135                                                      
REMARK 465     THR P   136                                                      
REMARK 465     HIS P   137                                                      
REMARK 465     SER P   138                                                      
REMARK 465     SER P   139                                                      
REMARK 465     ARG P   140                                                      
REMARK 465     PHE P   141                                                      
REMARK 465     ILE P   142                                                      
REMARK 465     PRO P   143                                                      
REMARK 465     LEU P   144                                                      
REMARK 465     LYS P   145                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     PRO Q     2                                                      
REMARK 465     SER Q     3                                                      
REMARK 465     LYS Q     4                                                      
REMARK 465     GLY Q     5                                                      
REMARK 465     PRO Q     6                                                      
REMARK 465     LEU Q     7                                                      
REMARK 465     MET R     1                                                      
REMARK 465     VAL R    88                                                      
REMARK 465     SER R    89                                                      
REMARK 465     ALA R    90                                                      
REMARK 465     LEU R    91                                                      
REMARK 465     ASP R    92                                                      
REMARK 465     GLN R    93                                                      
REMARK 465     GLU R    94                                                      
REMARK 465     ILE R    95                                                      
REMARK 465     ILE R    96                                                      
REMARK 465     GLU R    97                                                      
REMARK 465     VAL R    98                                                      
REMARK 465     ASP R    99                                                      
REMARK 465     THR R   123                                                      
REMARK 465     VAL R   124                                                      
REMARK 465     GLY R   125                                                      
REMARK 465     MET R   126                                                      
REMARK 465     ASN R   127                                                      
REMARK 465     PHE R   128                                                      
REMARK 465     LYS R   129                                                      
REMARK 465     THR R   130                                                      
REMARK 465     PRO R   131                                                      
REMARK 465     ARG R   132                                                      
REMARK 465     GLY R   133                                                      
REMARK 465     PRO R   134                                                      
REMARK 465     VAL R   135                                                      
REMARK 465     MET S     1                                                      
REMARK 465     ARG S   144                                                      
REMARK 465     THR S   145                                                      
REMARK 465     VAL S   146                                                      
REMARK 465     GLY S   147                                                      
REMARK 465     VAL S   148                                                      
REMARK 465     SER S   149                                                      
REMARK 465     LYS S   150                                                      
REMARK 465     LYS S   151                                                      
REMARK 465     LYS S   152                                                      
REMARK 465     MET T     1                                                      
REMARK 465     HIS T   145                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ALA U     2                                                      
REMARK 465     PHE U     3                                                      
REMARK 465     LYS U     4                                                      
REMARK 465     ASP U     5                                                      
REMARK 465     THR U     6                                                      
REMARK 465     GLY U     7                                                      
REMARK 465     LYS U     8                                                      
REMARK 465     THR U     9                                                      
REMARK 465     PRO U    10                                                      
REMARK 465     VAL U    11                                                      
REMARK 465     GLU U    12                                                      
REMARK 465     PRO U    13                                                      
REMARK 465     GLU U    14                                                      
REMARK 465     VAL U    15                                                      
REMARK 465     ALA U    16                                                      
REMARK 465     ILE U    17                                                      
REMARK 465     ALA U   119                                                      
REMARK 465     MET W     1                                                      
REMARK 465     MET X     1                                                      
REMARK 465     GLY X     2                                                      
REMARK 465     LYS X     3                                                      
REMARK 465     CYS X     4                                                      
REMARK 465     ARG X     5                                                      
REMARK 465     GLY X     6                                                      
REMARK 465     PRO X   141                                                      
REMARK 465     ARG X   142                                                      
REMARK 465     SER X   143                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASN Y     2                                                      
REMARK 465     ASP Y     3                                                      
REMARK 465     GLY Y   126                                                      
REMARK 465     ALA Y   127                                                      
REMARK 465     GLY Y   128                                                      
REMARK 465     LYS Y   129                                                      
REMARK 465     LYS Y   130                                                      
REMARK 465     PRO Y   131                                                      
REMARK 465     LYS Y   132                                                      
REMARK 465     GLU Y   133                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     ASP Z     5                                                      
REMARK 465     ASP Z     6                                                      
REMARK 465     LYS Z     7                                                      
REMARK 465     LYS Z     8                                                      
REMARK 465     LYS Z     9                                                      
REMARK 465     LYS Z    10                                                      
REMARK 465     ASP Z    11                                                      
REMARK 465     ALA Z    12                                                      
REMARK 465     GLY Z    13                                                      
REMARK 465     LYS Z    14                                                      
REMARK 465     SER Z    15                                                      
REMARK 465     ALA Z    16                                                      
REMARK 465     LYS Z    17                                                      
REMARK 465     LYS Z    18                                                      
REMARK 465     ASP Z    19                                                      
REMARK 465     LYS Z    20                                                      
REMARK 465     ASP Z    21                                                      
REMARK 465     PRO Z    22                                                      
REMARK 465     VAL Z    23                                                      
REMARK 465     ASN Z    24                                                      
REMARK 465     LYS Z    25                                                      
REMARK 465     SER Z    26                                                      
REMARK 465     GLY Z    27                                                      
REMARK 465     GLY Z    28                                                      
REMARK 465     LYS Z    29                                                      
REMARK 465     ALA Z    30                                                      
REMARK 465     LYS Z    31                                                      
REMARK 465     LYS Z    32                                                      
REMARK 465     LYS Z    33                                                      
REMARK 465     LYS Z    34                                                      
REMARK 465     TRP Z    35                                                      
REMARK 465     SER Z    36                                                      
REMARK 465     LYS Z    37                                                      
REMARK 465     GLY Z    38                                                      
REMARK 465     LYS Z    39                                                      
REMARK 465     GLY Z   116                                                      
REMARK 465     ASP Z   117                                                      
REMARK 465     ALA Z   118                                                      
REMARK 465     PRO Z   119                                                      
REMARK 465     ALA Z   120                                                      
REMARK 465     ALA Z   121                                                      
REMARK 465     GLY Z   122                                                      
REMARK 465     GLU Z   123                                                      
REMARK 465     ASP Z   124                                                      
REMARK 465     ALA Z   125                                                      
REMARK 465     MET a     1                                                      
REMARK 465     PRO a    98                                                      
REMARK 465     PRO a    99                                                      
REMARK 465     ARG a   100                                                      
REMARK 465     PHE a   101                                                      
REMARK 465     ARG a   102                                                      
REMARK 465     PRO a   103                                                      
REMARK 465     ALA a   104                                                      
REMARK 465     GLY a   105                                                      
REMARK 465     ALA a   106                                                      
REMARK 465     ALA a   107                                                      
REMARK 465     PRO a   108                                                      
REMARK 465     ARG a   109                                                      
REMARK 465     PRO a   110                                                      
REMARK 465     PRO a   111                                                      
REMARK 465     PRO a   112                                                      
REMARK 465     LYS a   113                                                      
REMARK 465     PRO a   114                                                      
REMARK 465     MET a   115                                                      
REMARK 465     MET b     1                                                      
REMARK 465     PRO b     2                                                      
REMARK 465     LEU b     3                                                      
REMARK 465     HIS b    84                                                      
REMARK 465     MET c     1                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     THR c     3                                                      
REMARK 465     SER c     4                                                      
REMARK 465     ARG c     5                                                      
REMARK 465     VAL c     6                                                      
REMARK 465     GLN c     7                                                      
REMARK 465     MET d     1                                                      
REMARK 465     GLY d     2                                                      
REMARK 465     HIS d     3                                                      
REMARK 465     LYS e     1                                                      
REMARK 465     VAL e     2                                                      
REMARK 465     HIS e     3                                                      
REMARK 465     GLY e     4                                                      
REMARK 465     SER e     5                                                      
REMARK 465     ALA e    57                                                      
REMARK 465     ASN e    58                                                      
REMARK 465     SER e    59                                                      
REMARK 465     MET f     1                                                      
REMARK 465     GLN f     2                                                      
REMARK 465     ILE f     3                                                      
REMARK 465     PHE f     4                                                      
REMARK 465     VAL f     5                                                      
REMARK 465     LYS f     6                                                      
REMARK 465     THR f     7                                                      
REMARK 465     LEU f     8                                                      
REMARK 465     THR f     9                                                      
REMARK 465     GLY f    10                                                      
REMARK 465     LYS f    11                                                      
REMARK 465     THR f    12                                                      
REMARK 465     ILE f    13                                                      
REMARK 465     THR f    14                                                      
REMARK 465     LEU f    15                                                      
REMARK 465     GLU f    16                                                      
REMARK 465     VAL f    17                                                      
REMARK 465     GLU f    18                                                      
REMARK 465     PRO f    19                                                      
REMARK 465     SER f    20                                                      
REMARK 465     ASP f    21                                                      
REMARK 465     THR f    22                                                      
REMARK 465     ILE f    23                                                      
REMARK 465     GLU f    24                                                      
REMARK 465     ASN f    25                                                      
REMARK 465     VAL f    26                                                      
REMARK 465     LYS f    27                                                      
REMARK 465     ALA f    28                                                      
REMARK 465     LYS f    29                                                      
REMARK 465     ILE f    30                                                      
REMARK 465     GLN f    31                                                      
REMARK 465     ASP f    32                                                      
REMARK 465     LYS f    33                                                      
REMARK 465     GLU f    34                                                      
REMARK 465     GLY f    35                                                      
REMARK 465     ILE f    36                                                      
REMARK 465     PRO f    37                                                      
REMARK 465     PRO f    38                                                      
REMARK 465     ASP f    39                                                      
REMARK 465     GLN f    40                                                      
REMARK 465     GLN f    41                                                      
REMARK 465     ARG f    42                                                      
REMARK 465     LEU f    43                                                      
REMARK 465     ILE f    44                                                      
REMARK 465     PHE f    45                                                      
REMARK 465     ALA f    46                                                      
REMARK 465     GLY f    47                                                      
REMARK 465     LYS f    48                                                      
REMARK 465     GLN f    49                                                      
REMARK 465     LEU f    50                                                      
REMARK 465     GLU f    51                                                      
REMARK 465     ASP f    52                                                      
REMARK 465     GLY f    53                                                      
REMARK 465     ARG f    54                                                      
REMARK 465     THR f    55                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     SER f    57                                                      
REMARK 465     ASP f    58                                                      
REMARK 465     TYR f    59                                                      
REMARK 465     ASN f    60                                                      
REMARK 465     ILE f    61                                                      
REMARK 465     GLN f    62                                                      
REMARK 465     LYS f    63                                                      
REMARK 465     GLU f    64                                                      
REMARK 465     SER f    65                                                      
REMARK 465     THR f    66                                                      
REMARK 465     LEU f    67                                                      
REMARK 465     HIS f    68                                                      
REMARK 465     LEU f    69                                                      
REMARK 465     VAL f    70                                                      
REMARK 465     LEU f    71                                                      
REMARK 465     ARG f    72                                                      
REMARK 465     LEU f    73                                                      
REMARK 465     ARG f    74                                                      
REMARK 465     GLY f    75                                                      
REMARK 465     GLY f    76                                                      
REMARK 465     ALA f    77                                                      
REMARK 465     LYS f    78                                                      
REMARK 465     LYS f    79                                                      
REMARK 465     ARG f    80                                                      
REMARK 465     LYS f    81                                                      
REMARK 465     LYS f    82                                                      
REMARK 465     LYS f    83                                                      
REMARK 465     SER f    84                                                      
REMARK 465     TYR f    85                                                      
REMARK 465     THR f    86                                                      
REMARK 465     THR f    87                                                      
REMARK 465     PRO f    88                                                      
REMARK 465     LYS f    89                                                      
REMARK 465     LYS f    90                                                      
REMARK 465     LYS f   152                                                      
REMARK 465     PRO f   153                                                      
REMARK 465     GLU f   154                                                      
REMARK 465     ASP f   155                                                      
REMARK 465     LYS f   156                                                      
REMARK 465     MET g     1                                                      
REMARK 465     THR g   316                                                      
REMARK 465     ARG g   317                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   N2     G 1  1639     O2'    G j  6195              0.44            
REMARK 500   O3'    A 1  1640     O2'    C j  6194              0.47            
REMARK 500   C4     C 1  1698     N7     G j  6220              0.51            
REMARK 500   CA   GLY F   132     P      U j  6211              0.56            
REMARK 500   C3'    G 1  1330     NH2  ARG h    65              0.63            
REMARK 500   C4'    G 1  1330     NH1  ARG h    65              0.66            
REMARK 500   C5'    A 1  1640     C5'    G j  6195              0.71            
REMARK 500   OP1    C 1  1237     OE1  GLN h    80              0.84            
REMARK 500   C1'    C 1  1698     C2     G j  6220              0.89            
REMARK 500   O    ARG Q   146     O5'    U j  6186              0.90            
REMARK 500   C1'    C 1  1701     O4     U j  6217              0.91            
REMARK 500   CB   ARG Q   146     OP2    U j  6186              0.92            
REMARK 500   O4     U 1  1509     NZ   LYS h   106              0.93            
REMARK 500   N4     C 1  1698     N7     G j  6220              0.96            
REMARK 500   CA   GLY F   132     OP1    U j  6211              0.97            
REMARK 500   C5'    G 1  1330     NH1  ARG h    65              0.98            
REMARK 500   CA   ARG Q   146     OP2    U j  6186              0.99            
REMARK 500   C4     C 1  1698     C5     G j  6220              1.01            
REMARK 500   N1     C 1  1698     N1     G j  6220              1.03            
REMARK 500   N3     C 1  1698     C5     G j  6220              1.04            
REMARK 500   O2'    C 1  1701     C4     U j  6217              1.06            
REMARK 500   N1     C 1  1698     C2     G j  6220              1.07            
REMARK 500   C2     G 1  1639     O2'    G j  6195              1.07            
REMARK 500   N2     G 1  1639     C2'    G j  6195              1.09            
REMARK 500   C1'    C 1  1698     N2     G j  6220              1.10            
REMARK 500   O4'    A 1  1640     O4'    G j  6195              1.10            
REMARK 500   C4     U 1  1509     NZ   LYS h   106              1.12            
REMARK 500   N4     C 1  1698     C8     G j  6220              1.15            
REMARK 500   C    LYS e    51     N4     C j  6226              1.20            
REMARK 500   C    ARG Q   146     P      U j  6186              1.21            
REMARK 500   C4'    G 1  1330     CZ   ARG h    65              1.23            
REMARK 500   C4     C 1  1698     C8     G j  6220              1.29            
REMARK 500   O2'    C 1  1701     C5     U j  6217              1.32            
REMARK 500   CA   LYS e    51     N4     C j  6226              1.32            
REMARK 500   O    LYS e    51     N4     C j  6226              1.33            
REMARK 500   C3'    G 1  1330     CZ   ARG h    65              1.33            
REMARK 500   C2'    C 1  1701     O4     U j  6217              1.34            
REMARK 500   O4'    A 1  1640     C4'    G j  6195              1.35            
REMARK 500   N    GLY F   132     OP1    U j  6211              1.37            
REMARK 500   C2'    G 1  1330     NH2  ARG h    65              1.38            
REMARK 500   C1'    C 1  1698     N1     G j  6220              1.39            
REMARK 500   C5'    G 1  1330     CZ   ARG h    65              1.40            
REMARK 500   C2'    C 1  1698     N2     G j  6220              1.41            
REMARK 500   C2     C 1  1698     C4     G j  6220              1.43            
REMARK 500   C3'    A 1  1640     O2'    C j  6194              1.44            
REMARK 500   C4'    A 1  1640     C5'    G j  6195              1.44            
REMARK 500   C2'    C 1  1701     C4     U j  6217              1.44            
REMARK 500   C2     C 1  1698     C5     G j  6220              1.46            
REMARK 500   C    GLY F   132     P      U j  6211              1.47            
REMARK 500   CG2  VAL F   134     OP1    U j  6210              1.47            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     178 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500      A 1 992   C6      A 1 992   N6     -0.050                       
REMARK 500      U j6040   C4      U j6040   O4      0.048                       
REMARK 500      U j6046   N3      U j6046   C4     -0.058                       
REMARK 500      U j6047   C4      U j6047   O4      0.080                       
REMARK 500      G j6048   C5      G j6048   N7      0.036                       
REMARK 500      G j6048   C8      G j6048   N9     -0.043                       
REMARK 500      A j6050   C6      A j6050   N1      0.055                       
REMARK 500      U j6058   O3'     U j6059   P       0.093                       
REMARK 500      A j6078   N9      A j6078   C4      0.073                       
REMARK 500      C j6079   N3      C j6079   C4      0.134                       
REMARK 500      G j6082   C5      G j6082   N7      0.038                       
REMARK 500      U j6091   N1      U j6091   C2      0.084                       
REMARK 500      U j6091   C5      U j6091   C6      0.074                       
REMARK 500      U j6092   C2      U j6092   N3     -0.061                       
REMARK 500      G j6104   N1      G j6104   C2     -0.052                       
REMARK 500      G j6104   N3      G j6104   C4     -0.074                       
REMARK 500      G j6104   C6      G j6104   N1      0.070                       
REMARK 500      G j6104   N7      G j6104   C8      0.047                       
REMARK 500      G j6108   N7      G j6108   C8     -0.045                       
REMARK 500      C j6109   N1      C j6109   C6     -0.044                       
REMARK 500      C j6109   N3      C j6109   C4      0.048                       
REMARK 500      A j6115   C6      A j6115   N1      0.069                       
REMARK 500      G j6141   C6      G j6141   N1     -0.042                       
REMARK 500      C j6142   N1      C j6142   C6     -0.039                       
REMARK 500      G j6144   C8      G j6144   N9     -0.066                       
REMARK 500      G j6144   N9      G j6144   C4     -0.059                       
REMARK 500      C j6145   C2      C j6145   O2      0.062                       
REMARK 500      C j6145   N3      C j6145   C4      0.066                       
REMARK 500      G j6159   C6      G j6159   O6     -0.060                       
REMARK 500      G j6160   C5      G j6160   N7      0.057                       
REMARK 500      A j6161   C5      A j6161   N7      0.057                       
REMARK 500      C j6166   O3'     U j6167   P      -0.125                       
REMARK 500      U j6167   O3'     C j6168   P      -0.082                       
REMARK 500      C j6170   O3'     U j6171   P       0.088                       
REMARK 500      G j6172   O3'     C j6173   P       0.094                       
REMARK 500      C j6173   O3'     G j6174   P      -0.242                       
REMARK 500      U j6177   O3'     A j6178   P      -0.221                       
REMARK 500      A j6178   O3'     U j6179   P      -0.076                       
REMARK 500      C j6181   O3'     A j6182   P       0.078                       
REMARK 500      A j6182   O3'     G j6183   P      -0.158                       
REMARK 500      A j6197   O3'     A j6198   P      -0.073                       
REMARK 500      A j6198   O3'     A j6199   P       0.162                       
REMARK 500      A j6199   O3'     A j6200   P      -0.121                       
REMARK 500      G j6206   O3'     A j6207   P       0.180                       
REMARK 500      A j6207   O3'     A j6208   P      -0.144                       
REMARK 500      A j6213   O3'     C j6214   P      -0.172                       
REMARK 500      C j6215   O3'     U j6216   P      -0.187                       
REMARK 500      U j6216   O3'     U j6217   P       0.122                       
REMARK 500      A j6219   O3'     G j6220   P      -0.192                       
REMARK 500      C j6225   O3'     C j6226   P      -0.087                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      51 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      C 1 502   C3' -  C2' -  C1' ANGL. DEV. =  -4.6 DEGREES          
REMARK 500      C 1 645   C3' -  C2' -  C1' ANGL. DEV. =  -4.2 DEGREES          
REMARK 500      U 11441   C3' -  C2' -  C1' ANGL. DEV. =  -4.2 DEGREES          
REMARK 500      A j6030   C2  -  N3  -  C4  ANGL. DEV. =  -3.8 DEGREES          
REMARK 500      A j6030   N3  -  C4  -  C5  ANGL. DEV. =   7.8 DEGREES          
REMARK 500      A j6030   C4  -  C5  -  C6  ANGL. DEV. =  -4.4 DEGREES          
REMARK 500      A j6030   N3  -  C4  -  N9  ANGL. DEV. =  -7.3 DEGREES          
REMARK 500      A j6031   C6  -  N1  -  C2  ANGL. DEV. =   7.1 DEGREES          
REMARK 500      A j6031   N1  -  C2  -  N3  ANGL. DEV. =  -5.1 DEGREES          
REMARK 500      A j6031   C5  -  C6  -  N1  ANGL. DEV. =  -3.2 DEGREES          
REMARK 500      A j6031   N1  -  C6  -  N6  ANGL. DEV. =   4.3 DEGREES          
REMARK 500      U j6040   C2  -  N3  -  C4  ANGL. DEV. =  -4.4 DEGREES          
REMARK 500      U j6040   N3  -  C4  -  C5  ANGL. DEV. =   4.9 DEGREES          
REMARK 500      U j6040   N1  -  C2  -  O2  ANGL. DEV. =  -6.5 DEGREES          
REMARK 500      U j6046   N1  -  C2  -  N3  ANGL. DEV. =   5.9 DEGREES          
REMARK 500      U j6046   C2  -  N3  -  C4  ANGL. DEV. =  -8.9 DEGREES          
REMARK 500      U j6046   N3  -  C4  -  C5  ANGL. DEV. =   7.9 DEGREES          
REMARK 500      U j6046   C5  -  C4  -  O4  ANGL. DEV. =  -5.7 DEGREES          
REMARK 500      U j6047   N1  -  C2  -  N3  ANGL. DEV. =   5.3 DEGREES          
REMARK 500      U j6047   C2  -  N3  -  C4  ANGL. DEV. =  -6.1 DEGREES          
REMARK 500      U j6047   N1  -  C2  -  O2  ANGL. DEV. =  -5.6 DEGREES          
REMARK 500      G j6048   C2  -  N3  -  C4  ANGL. DEV. =   5.6 DEGREES          
REMARK 500      G j6048   N3  -  C4  -  C5  ANGL. DEV. =  -3.4 DEGREES          
REMARK 500      G j6048   C5  -  C6  -  N1  ANGL. DEV. =   3.5 DEGREES          
REMARK 500      G j6048   C8  -  N9  -  C4  ANGL. DEV. =   3.0 DEGREES          
REMARK 500      G j6048   N3  -  C4  -  N9  ANGL. DEV. =   3.9 DEGREES          
REMARK 500      G j6048   C6  -  C5  -  N7  ANGL. DEV. =   3.7 DEGREES          
REMARK 500      G j6048   N1  -  C6  -  O6  ANGL. DEV. =   4.1 DEGREES          
REMARK 500      G j6048   C5  -  C6  -  O6  ANGL. DEV. =  -7.8 DEGREES          
REMARK 500      U j6049   C2  -  N3  -  C4  ANGL. DEV. =  -5.3 DEGREES          
REMARK 500      U j6049   N3  -  C4  -  C5  ANGL. DEV. =   5.3 DEGREES          
REMARK 500      U j6049   N1  -  C2  -  O2  ANGL. DEV. =   6.9 DEGREES          
REMARK 500      U j6049   N3  -  C2  -  O2  ANGL. DEV. = -10.2 DEGREES          
REMARK 500      U j6049   C5  -  C4  -  O4  ANGL. DEV. =  -7.0 DEGREES          
REMARK 500      A j6050   C8  -  N9  -  C4  ANGL. DEV. =  -3.1 DEGREES          
REMARK 500      A j6050   N9  -  C4  -  C5  ANGL. DEV. =   3.6 DEGREES          
REMARK 500      A j6050   N3  -  C4  -  N9  ANGL. DEV. =  -5.0 DEGREES          
REMARK 500      A j6051   C6  -  N1  -  C2  ANGL. DEV. =   3.9 DEGREES          
REMARK 500      A j6070   C3' -  O3' -  P   ANGL. DEV. =   8.1 DEGREES          
REMARK 500      U j6077   C2  -  N3  -  C4  ANGL. DEV. =  -9.0 DEGREES          
REMARK 500      U j6077   N3  -  C4  -  C5  ANGL. DEV. =   8.0 DEGREES          
REMARK 500      U j6077   N3  -  C4  -  O4  ANGL. DEV. =  -6.2 DEGREES          
REMARK 500      A j6078   N1  -  C2  -  N3  ANGL. DEV. =  -3.6 DEGREES          
REMARK 500      A j6078   C4  -  C5  -  N7  ANGL. DEV. =  -3.1 DEGREES          
REMARK 500      A j6078   C5  -  N7  -  C8  ANGL. DEV. =   5.8 DEGREES          
REMARK 500      A j6078   N7  -  C8  -  N9  ANGL. DEV. =  -3.5 DEGREES          
REMARK 500      A j6078   N1  -  C6  -  N6  ANGL. DEV. =   6.3 DEGREES          
REMARK 500      A j6078   C5  -  C6  -  N6  ANGL. DEV. =  -4.9 DEGREES          
REMARK 500      C j6079   C6  -  N1  -  C2  ANGL. DEV. =  -3.7 DEGREES          
REMARK 500      C j6079   C2  -  N3  -  C4  ANGL. DEV. =   3.8 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     166 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A   5      -99.94    -90.24                                   
REMARK 500    ASP A   6      -60.14    170.03                                   
REMARK 500    TYR A  39      -89.98   -110.02                                   
REMARK 500    ALA A  96       -2.87   -156.01                                   
REMARK 500    THR A 104       91.93     79.31                                   
REMARK 500    ARG A 205      177.87    179.99                                   
REMARK 500    ASP B  23       89.96     18.77                                   
REMARK 500    MET B  38       30.01    -79.73                                   
REMARK 500    PHE B  39     -153.58   -139.98                                   
REMARK 500    ASN B  40      -98.83   -110.04                                   
REMARK 500    ILE B  44      -73.32   -106.56                                   
REMARK 500    VAL B  49     -113.35   -130.03                                   
REMARK 500    THR B  52       12.47    -59.95                                   
REMARK 500    THR B  55      142.28     86.07                                   
REMARK 500    ASN B  76      -52.99    113.15                                   
REMARK 500    GLU B  78      -39.99    130.00                                   
REMARK 500    PHE B  81     -163.37   -116.67                                   
REMARK 500    ARG B  82       86.14     79.97                                   
REMARK 500    TRP B 117       16.02     80.37                                   
REMARK 500    VAL B 127     -179.99   -179.99                                   
REMARK 500    ASN B 148       16.76    110.10                                   
REMARK 500    LYS B 152        1.58    -63.97                                   
REMARK 500    THR B 153      -89.94   -100.09                                   
REMARK 500    SER B 154       73.75     99.97                                   
REMARK 500    HIS B 158      -60.32     69.94                                   
REMARK 500    VAL B 176     -139.60    -79.43                                   
REMARK 500    GLN B 177       30.03     20.01                                   
REMARK 500    ASP B 180     -161.11     62.55                                   
REMARK 500    ILE B 204      -66.71    -97.02                                   
REMARK 500    LEU B 207      130.15     51.39                                   
REMARK 500    ASP B 209      -93.58     87.42                                   
REMARK 500    VAL B 210       89.95     70.05                                   
REMARK 500    ARG B 213      -79.94     59.98                                   
REMARK 500    PRO B 221      -87.30    -60.64                                   
REMARK 500    THR C  64      147.73    110.04                                   
REMARK 500    LYS C 108      149.76   -170.92                                   
REMARK 500    ASN C 172      128.30    120.16                                   
REMARK 500    ILE C 174     -139.97     30.01                                   
REMARK 500    LYS C 176      121.20     52.98                                   
REMARK 500    PHE C 261       88.20     82.24                                   
REMARK 500    SER D  35      -70.06    -89.99                                   
REMARK 500    GLU D  61      -79.90    -89.97                                   
REMARK 500    GLU D  81       -1.17    -49.89                                   
REMARK 500    LEU D 142      100.00    -29.95                                   
REMARK 500    ASP D 193      107.41   -170.20                                   
REMARK 500    GLU E  40       67.13   -110.77                                   
REMARK 500    ARG E  49      -70.03    -80.04                                   
REMARK 500    ARG E  68       52.09   -108.71                                   
REMARK 500    LYS E 134       32.03     70.02                                   
REMARK 500    THR E 196      -78.30    -89.92                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     246 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500      U 1  44         0.06    SIDE CHAIN                              
REMARK 500      A 1  77         0.06    SIDE CHAIN                              
REMARK 500      A 1  84         0.08    SIDE CHAIN                              
REMARK 500      G 1  88         0.05    SIDE CHAIN                              
REMARK 500      A 1 111         0.08    SIDE CHAIN                              
REMARK 500      C 1 216         0.06    SIDE CHAIN                              
REMARK 500      A 1 235         0.07    SIDE CHAIN                              
REMARK 500      C 1 570         0.07    SIDE CHAIN                              
REMARK 500      U 1 572         0.09    SIDE CHAIN                              
REMARK 500      A 1 643         0.07    SIDE CHAIN                              
REMARK 500      C 1 645         0.06    SIDE CHAIN                              
REMARK 500      U 1 747         0.07    SIDE CHAIN                              
REMARK 500      U 1 799         0.07    SIDE CHAIN                              
REMARK 500      G 1 867         0.07    SIDE CHAIN                              
REMARK 500      U 1 897         0.09    SIDE CHAIN                              
REMARK 500      U 11120         0.13    SIDE CHAIN                              
REMARK 500      U 11288         0.11    SIDE CHAIN                              
REMARK 500      U 11308         0.07    SIDE CHAIN                              
REMARK 500      A 11414         0.06    SIDE CHAIN                              
REMARK 500      G 11548         0.08    SIDE CHAIN                              
REMARK 500      U 11578         0.07    SIDE CHAIN                              
REMARK 500      U 11624         0.13    SIDE CHAIN                              
REMARK 500      G 11686         0.06    SIDE CHAIN                              
REMARK 500      A 11823         0.06    SIDE CHAIN                              
REMARK 500      G j6160         0.06    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 700                                                                      
REMARK 700 SHEET                                                                
REMARK 700 DETERMINATION METHOD: DSSP                                           
REMARK 700 THE SHEETS PRESENTED AS "BB" IN EACH CHAIN ON SHEET RECORDS          
REMARK 700 BELOW IS ACTUALLY AN -7-STRANDED BARREL THIS IS REPRESENTED BY       
REMARK 700 A -6-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS              
REMARK 700 ARE IDENTICAL.                                                       
REMARK 700 THE SHEETS PRESENTED AS "BD" IN EACH CHAIN ON SHEET RECORDS          
REMARK 700 BELOW IS ACTUALLY AN -2-STRANDED BARREL THIS IS REPRESENTED BY       
REMARK 700 A -1-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS              
REMARK 700 ARE IDENTICAL.                                                       
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-2813   RELATED DB: EMDB                              
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 AUTHORS HAVE USED HUMAN SEQUENCE FOR MODEL BUILDING, WITH            
REMARK 999 FOLLOWING PDB-GENBANK OR UNIPROT RESIDUE MAPPING:                    
REMARK 999  CHAIN: 1    1-1742  GB    X03205.1    1   1742                      
REMARK 999  CHAIN: A    1-295  UNP    P08865      1    295                      
REMARK 999  CHAIN: B    1- 264  UNP   P61247      1    264                      
REMARK 999  CHAIN: C    1-293  UNP    P15880      1    293                      
REMARK 999  CHAIN: D    1-243  UNP    P23396      1    243                      
REMARK 999  CHAIN: E    1-263  UNP    P22090      1    263                      
REMARK 999  CHAIN: F    1-204  UNP    P46782      1    204                      
REMARK 999  CHAIN: G    1-249  UNP    P62753      1    249                      
REMARK 999  CHAIN: H    1-194  UNP    P62081      1    194                      
REMARK 999  CHAIN: I    1-208  UNP    P62241      1    208                      
REMARK 999  CHAIN: J    1-194  UNP    P46781      1    194                      
REMARK 999  CHAIN: K    1-165  UNP    P46783      1    165                      
REMARK 999  CHAIN: L    1-158  UNP    P62280      1    158                      
REMARK 999  CHAIN: M    1-132  UNP    P25398      1    132                      
REMARK 999  CHAIN: N    1-151  UNP    P62277      1    151                      
REMARK 999  CHAIN: O    1-151  UNP    P62263      1    151                      
REMARK 999  CHAIN: P    1-145  UNP    P62841      1    145                      
REMARK 999  CHAIN: Q    1-146  UNP    P62249      1    146                      
REMARK 999  CHAIN: R    1-135  UNP    P08708      1    135                      
REMARK 999  CHAIN: S    1-152  UNP    P62269      1    152                      
REMARK 999  CHAIN: T    1-145  UNP    P39019      1    145                      
REMARK 999  CHAIN: U    1-119  UNP    P60866      1    119                      
REMARK 999  CHAIN: V    1- 83  UNP    P63220      1     83                      
REMARK 999  CHAIN: W    1-130  UNP    P62244      1    130                      
REMARK 999  CHAIN: X    1-143  UNP    P62266      1    143                      
REMARK 999  CHAIN: Y    1-133  UNP    P62847      1    133                      
REMARK 999  CHAIN: Z    1-125  UNP    P62851      1    125                      
REMARK 999  CHAIN: A    1-115  UNP    P62854      1    115                      
REMARK 999  CHAIN: B    1-84   UNP    P42677      1     84                      
REMARK 999  CHAIN: C    1-69   UNP    P62857      1     69                      
REMARK 999  CHAIN: D    1-56   UNP    P62273      1     56                      
REMARK 999  CHAIN: E    1-59   UNP    P62861      1     59                      
REMARK 999  CHAIN: F    1-156  UNP    P62979      1    156                      
REMARK 999  CHAIN: G    1-317  UNP    P63244      1    317                      
DBREF  4D61 1    1  1742  PDB    4D61     4D61             1   1742             
DBREF  4D61 A    1   295  PDB    4D61     4D61             1    295             
DBREF  4D61 B    1   264  PDB    4D61     4D61             1    264             
DBREF  4D61 C    1   293  PDB    4D61     4D61             1    293             
DBREF  4D61 D    1   243  PDB    4D61     4D61             1    243             
DBREF  4D61 E    1   263  PDB    4D61     4D61             1    263             
DBREF  4D61 F    1   204  PDB    4D61     4D61             1    204             
DBREF  4D61 G    1   249  PDB    4D61     4D61             1    249             
DBREF  4D61 H    1   194  PDB    4D61     4D61             1    194             
DBREF  4D61 I    1   208  PDB    4D61     4D61             1    208             
DBREF  4D61 J    1   194  PDB    4D61     4D61             1    194             
DBREF  4D61 K    1   165  PDB    4D61     4D61             1    165             
DBREF  4D61 L    1   158  PDB    4D61     4D61             1    158             
DBREF  4D61 M    1   132  PDB    4D61     4D61             1    132             
DBREF  4D61 N    1   151  PDB    4D61     4D61             1    151             
DBREF  4D61 O    1   151  PDB    4D61     4D61             1    151             
DBREF  4D61 P    1   145  PDB    4D61     4D61             1    145             
DBREF  4D61 Q    1   146  PDB    4D61     4D61             1    146             
DBREF  4D61 R    1   135  PDB    4D61     4D61             1    135             
DBREF  4D61 S    1   152  PDB    4D61     4D61             1    152             
DBREF  4D61 T    1   145  PDB    4D61     4D61             1    145             
DBREF  4D61 U    1   119  PDB    4D61     4D61             1    119             
DBREF  4D61 V    1    83  PDB    4D61     4D61             1     83             
DBREF  4D61 W    1   130  PDB    4D61     4D61             1    130             
DBREF  4D61 X    1   143  PDB    4D61     4D61             1    143             
DBREF  4D61 Y    1   133  PDB    4D61     4D61             1    133             
DBREF  4D61 Z    1   125  PDB    4D61     4D61             1    125             
DBREF  4D61 a    1   115  PDB    4D61     4D61             1    115             
DBREF  4D61 b    1    84  PDB    4D61     4D61             1     84             
DBREF  4D61 c    1    69  PDB    4D61     4D61             1     69             
DBREF  4D61 d    1    56  PDB    4D61     4D61             1     56             
DBREF  4D61 e    1    59  PDB    4D61     4D61             1     59             
DBREF  4D61 f    1   156  PDB    4D61     4D61             1    156             
DBREF  4D61 g    1   317  PDB    4D61     4D61             1    317             
DBREF  4D61 h    5   437  UNP    P62495   ERF1_HUMAN       5    437             
DBREF  4D61 i  201   626  UNP    P15170   ERF3A_HUMAN    210    635             
DBREF  4D61 j 6030  6216  GB     AF218039 AF218039      6030   6216             
DBREF  4D61 j 6217  6230  PDB    4D61     4D61          6217   6230             
SEQADV 4D61 LEU h  438  UNP  P62495              EXPRESSION TAG                 
SEQADV 4D61 GLU h  439  UNP  P62495              EXPRESSION TAG                 
SEQADV 4D61 HIS h  440  UNP  P62495              EXPRESSION TAG                 
SEQRES   1 1 1869    U   A   C   C   U   G   G   U   U   G   A   U   C          
SEQRES   2 1 1869    C   U   G   C   C   A   G   U   A   G   C   A   U          
SEQRES   3 1 1869    A   U   G   C   U   U   G   U   C   U   C   A   A          
SEQRES   4 1 1869    A   G   A   U   U   A   A   G   C   C   A   U   G          
SEQRES   5 1 1869    C   A   U   G   U   C   U   A   A   G   U   A   C          
SEQRES   6 1 1869    G   C   A   C   G   G   C   C   G   G   U   A   C          
SEQRES   7 1 1869    A   G   U   G   A   A   A   C   U   G   C   G   A          
SEQRES   8 1 1869    A   U   G   G   C   U   C   A   U   U   A   A   A          
SEQRES   9 1 1869    U   C   A   G   U   U   A   U   G   G   U   U   C          
SEQRES  10 1 1869    C   U   U   U   G   G   U   C   G   C   U   C   G          
SEQRES  11 1 1869    C   U   C   C   U   C   U   C   C   C   A   C   U          
SEQRES  12 1 1869    U   G   G   A   U   A   A   C   U   G   U   G   G          
SEQRES  13 1 1869    U   A   A   U   U   C   U   A   G   A   G   C   U          
SEQRES  14 1 1869    A   A   U   A   C   A   U   G   C   C   G   A   C          
SEQRES  15 1 1869    G   G   G   C   G   C   U   G   A   C   C   C   C          
SEQRES  16 1 1869    C   U   U   C   G   C   G   G   G   G   G   G   G          
SEQRES  17 1 1869    A   U   G   C   G   U   G   C   A   U   U   U   A          
SEQRES  18 1 1869    U   C   A   G   A   U   C   A   A   A   A   C   C          
SEQRES  19 1 1869    A   A   C   C   C   G   G   U   C   A   G   C   C          
SEQRES  20 1 1869    C   C   U   C   U   C   C   G   G   C   C   C   C          
SEQRES  21 1 1869    G   G   C   C   G   G   G   G   G   G   C   G   G          
SEQRES  22 1 1869    G   C   G   C   C   G   G   C   G   G   C   U   U          
SEQRES  23 1 1869    U   G   G   U   G   A   C   U   C   U   A   G   A          
SEQRES  24 1 1869    U   A   A   C   C   U   C   G   G   G   C   C   G          
SEQRES  25 1 1869    A   U   C   G   C   A   C   G   C   C   C   C   C          
SEQRES  26 1 1869    C   G   U   G   G   C   G   G   C   G   A   C   G          
SEQRES  27 1 1869    A   C   C   C   A   U   U   C   G   A   A   C   G          
SEQRES  28 1 1869    U   C   U   G   C   C   C   U   A   U   C   A   A          
SEQRES  29 1 1869    C   U   U   U   C   G   A   U   G   G   U   A   G          
SEQRES  30 1 1869    U   C   G   C   C   G   U   G   C   C   U   A   C          
SEQRES  31 1 1869    C   A   U   G   G   U   G   A   C   C   A   C   G          
SEQRES  32 1 1869    G   G   U   G   A   C   G   G   G   G   A   A   U          
SEQRES  33 1 1869    C   A   G   G   G   U   U   C   G   A   U   U   C          
SEQRES  34 1 1869    C   G   G   A   G   A   G   G   G   A   G   C   C          
SEQRES  35 1 1869    U   G   A   G   A   A   A   C   G   G   C   U   A          
SEQRES  36 1 1869    C   C   A   C   A   U   C   C   A   A   G   G   A          
SEQRES  37 1 1869    A   G   G   C   A   G   C   A   G   G   C   G   C          
SEQRES  38 1 1869    G   C   A   A   A   U   U   A   C   C   C   A   C          
SEQRES  39 1 1869    U   C   C   C   G   A   C   C   C   G   G   G   G          
SEQRES  40 1 1869    A   G   G   U   A   G   U   G   A   C   G   A   A          
SEQRES  41 1 1869    A   A   A   U   A   A   C   A   A   U   A   C   A          
SEQRES  42 1 1869    G   G   A   C   U   C   U   U   U   C   G   A   G          
SEQRES  43 1 1869    G   C   C   C   U   G   U   A   A   U   U   G   G          
SEQRES  44 1 1869    A   A   U   G   A   G   U   C   C   A   C   U   U          
SEQRES  45 1 1869    U   A   A   A   U   C   C   U   U   U   A   A   C          
SEQRES  46 1 1869    G   A   G   G   A   U   C   C   A   U   U   G   G          
SEQRES  47 1 1869    A   G   G   G   C   A   A   G   U   C   U   G   G          
SEQRES  48 1 1869    U   G   C   C   A   G   C   A   G   C   C   G   C          
SEQRES  49 1 1869    G   G   U   A   A   U   U   C   C   A   G   C   U          
SEQRES  50 1 1869    C   C   A   A   U   A   G   C   G   U   A   U   A          
SEQRES  51 1 1869    U   U   A   A   A   G   U   U   G   C   U   G   C          
SEQRES  52 1 1869    A   G   U   U   A   A   A   A   A   G   C   U   C          
SEQRES  53 1 1869    G   U   A   G   U   U   G   G   A   U   C   U   U          
SEQRES  54 1 1869    G   G   G   A   G   C   G   G   G   C   G   G   G          
SEQRES  55 1 1869    C   G   G   U   C   C   G   C   C   G   C   G   A          
SEQRES  56 1 1869    G   G   C   G   A   G   C   C   A   C   C   G   C          
SEQRES  57 1 1869    C   C   G   U   C   C   C   C   G   C   C   C   C          
SEQRES  58 1 1869    U   U   G   C   C   U   C   U   C   G   G   C   G          
SEQRES  59 1 1869    C   C   C   C   C   U   C   G   A   U   G   C   U          
SEQRES  60 1 1869    C   U   U   A   G   C   U   G   A   G   U   G   U          
SEQRES  61 1 1869    C   C   C   G   C   G   G   G   G   C   C   C   G          
SEQRES  62 1 1869    A   A   G   C   G   U   U   U   A   C   U   U   U          
SEQRES  63 1 1869    G   A   A   A   A   A   A   U   U   A   G   A   G          
SEQRES  64 1 1869    U   G   U   U   C   A   A   A   G   C   A   G   G          
SEQRES  65 1 1869    C   C   C   G   A   G   C   C   G   C   C   U   G          
SEQRES  66 1 1869    G   A   U   A   C   C   G   C   A   G   C   U   A          
SEQRES  67 1 1869    G   G   A   A   U   A   A   U   G   G   A   A   U          
SEQRES  68 1 1869    A   G   G   A   C   C   G   C   G   G   U   U   C          
SEQRES  69 1 1869    U   A   U   U   U   U   G   U   U   G   G   U   U          
SEQRES  70 1 1869    U   U   C   G   G   A   A   C   U   G   A   G   G          
SEQRES  71 1 1869    C   C   A   U   G   A   U   U   A   A   G   A   G          
SEQRES  72 1 1869    G   G   A   C   G   G   C   C   G   G   G   G   G          
SEQRES  73 1 1869    C   A   U   U   C   G   U   A   U   U   G   C   G          
SEQRES  74 1 1869    C   C   G   C   U   A   G   A   G   G   U   G   A          
SEQRES  75 1 1869    A   A   U   U   C   U   U   G   G   A   C   C   G          
SEQRES  76 1 1869    G   C   G   C   A   A   G   A   C   G   G   A   C          
SEQRES  77 1 1869    C   A   G   A   G   C   G   A   A   A   G   C   A          
SEQRES  78 1 1869    U   U   U   G   C   C   A   A   G   A   A   U   G          
SEQRES  79 1 1869    U   U   U   U   C   A   U   U   A   A   U   C   A          
SEQRES  80 1 1869    A   G   A   A   C   G   A   A   A   G   U   C   G          
SEQRES  81 1 1869    G   A   G   G   U   U   C   G   A   A   G   A   C          
SEQRES  82 1 1869    G   A   U   C   A   G   A   U   A   C   C   G   U          
SEQRES  83 1 1869    C   G   U   A   G   U   U   C   C   G   A   C   C          
SEQRES  84 1 1869    A   U   A   A   A   C   G   A   U   G   C   C   G          
SEQRES  85 1 1869    A   C   C   G   G   C   G   A   U   G   C   G   G          
SEQRES  86 1 1869    C   G   G   C   G   U   U   A   U   U   C   C   C          
SEQRES  87 1 1869    A   U   G   A   C   C   C   G   C   C   G   G   G          
SEQRES  88 1 1869    C   A   G   C   U   U   C   C   G   G   G   A   A          
SEQRES  89 1 1869    A   C   C   A   A   A   G   U   C   U   U   U   G          
SEQRES  90 1 1869    G   G   U   U   C   C   G   G   G   G   G   G   A          
SEQRES  91 1 1869    G   U   A   U   G   G   U   U   G   C   A   A   A          
SEQRES  92 1 1869    G   C   U   G   A   A   A   C   U   U   A   A   A          
SEQRES  93 1 1869    G   G   A   A   U   U   G   A   C   G   G   A   A          
SEQRES  94 1 1869    G   G   G   C   A   C   C   A   C   C   A   G   G          
SEQRES  95 1 1869    A   G   U   G   G   A   G   C   C   U   G   C   G          
SEQRES  96 1 1869    G   C   U   U   A   A   U   U   U   G   A   C   U          
SEQRES  97 1 1869    C   A   A   C   A   C   G   G   G   A   A   A   C          
SEQRES  98 1 1869    C   U   C   A   C   C   C   G   G   C   C   C   G          
SEQRES  99 1 1869    G   A   C   A   C   G   G   A   C   A   G   G   A          
SEQRES 100 1 1869    U   U   G   A   C   A   G   A   U   U   G   A   U          
SEQRES 101 1 1869    A   G   C   U   C   U   U   U   C   U   C   G   A          
SEQRES 102 1 1869    U   U   C   C   G   U   G   G   G   U   G   G   U          
SEQRES 103 1 1869    G   G   U   G   C   A   U   G   G   C   C   G   U          
SEQRES 104 1 1869    U   C   U   U   A   G   U   U   G   G   U   G   G          
SEQRES 105 1 1869    A   G   C   G   A   U   U   U   G   U   C   U   G          
SEQRES 106 1 1869    G   U   U   A   A   U   U   C   C   G   A   U   A          
SEQRES 107 1 1869    A   C   G   A   A   C   G   A   G   A   C   U   C          
SEQRES 108 1 1869    U   G   G   C   A   U   G   C   U   A   A   C   U          
SEQRES 109 1 1869    A   G   U   U   A   C   G   C   G   A   C   C   C          
SEQRES 110 1 1869    C   C   G   A   G   C   G   G   U   C   G   G   C          
SEQRES 111 1 1869    G   U   C   C   C   C   C   A   A   C   U   U   C          
SEQRES 112 1 1869    U   U   A   G   A   G   G   G   A   C   A   A   G          
SEQRES 113 1 1869    U   G   G   C   G   U   U   C   A   G   C   C   A          
SEQRES 114 1 1869    C   C   C   G   A   G   A   U   U   G   A   G   C          
SEQRES 115 1 1869    A   A   U   A   A   C   A   G   G   U   C   U   G          
SEQRES 116 1 1869    U   G   A   U   G   C   C   C   U   U   A   G   A          
SEQRES 117 1 1869    U   G   U   C   C   G   G   G   G   C   U   G   C          
SEQRES 118 1 1869    A   C   G   C   G   C   G   C   U   A   C   A   C          
SEQRES 119 1 1869    U   G   A   C   U   G   G   C   U   C   A   G   C          
SEQRES 120 1 1869    G   U   G   U   G   C   C   U   A   C   C   C   U          
SEQRES 121 1 1869    A   C   G   C   C   G   G   C   A   G   G   C   G          
SEQRES 122 1 1869    C   G   G   G   U   A   A   C   C   C   G   U   U          
SEQRES 123 1 1869    G   A   A   C   C   C   C   A   U   U   C   G   U          
SEQRES 124 1 1869    G   A   U   G   G   G   G   A   U   C   G   G   G          
SEQRES 125 1 1869    G   A   U   U   G   C   A   A   U   U   A   U   U          
SEQRES 126 1 1869    C   C   C   C   A   U   G   A   A   C   G   A   G          
SEQRES 127 1 1869    G   A   A   U   U   C   C   C   A   G   U   A   A          
SEQRES 128 1 1869    G   U   G   C   G   G   G   U   C   A   U   A   A          
SEQRES 129 1 1869    G   C   U   U   G   C   G   U   U   G   A   U   U          
SEQRES 130 1 1869    A   A   G   U   C   C   C   U   G   C   C   C   U          
SEQRES 131 1 1869    U   U   G   U   A   C   A   C   A   C   C   G   C          
SEQRES 132 1 1869    C   C   G   U   C   G   C   U   A   C   U   A   C          
SEQRES 133 1 1869    C   G   A   U   U   G   G   A   U   G   G   U   U          
SEQRES 134 1 1869    U   A   G   U   G   A   G   G   C   C   C   U   C          
SEQRES 135 1 1869    G   G   A   U   C   G   G   C   C   C   C   G   C          
SEQRES 136 1 1869    C   G   G   G   G   U   C   G   G   C   C   C   A          
SEQRES 137 1 1869    C   G   G   C   C   U   C   G   G   C   G   G   A          
SEQRES 138 1 1869    G   C   G   C   U   G   A   G   A   A   G   A   C          
SEQRES 139 1 1869    G   G   U   C   G   A   A   C   U   U   G   A   C          
SEQRES 140 1 1869    U   A   U   C   U   A   G   A   G   G   A   A   G          
SEQRES 141 1 1869    U   A   A   A   A   G   U   C   G   U   A   A   C          
SEQRES 142 1 1869    A   A   G   G   U   U   U   C   C   G   U   A   G          
SEQRES 143 1 1869    G   U   G   A   A   C   C   U   G   C   G   G   A          
SEQRES 144 1 1869    A   G   G   A   U   C   A   U   U   A                      
SEQRES   1 A  295  MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU          
SEQRES   2 A  295  ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY          
SEQRES   3 A  295  GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR          
SEQRES   4 A  295  LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS          
SEQRES   5 A  295  ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE          
SEQRES   6 A  295  VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER          
SEQRES   7 A  295  SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA          
SEQRES   8 A  295  ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR          
SEQRES   9 A  295  PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG          
SEQRES  10 A  295  GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP          
SEQRES  11 A  295  HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO          
SEQRES  12 A  295  THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR          
SEQRES  13 A  295  VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS          
SEQRES  14 A  295  SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL          
SEQRES  15 A  295  LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP          
SEQRES  16 A  295  GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU          
SEQRES  17 A  295  GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA          
SEQRES  18 A  295  VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO          
SEQRES  19 A  295  ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP          
SEQRES  20 A  295  TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN          
SEQRES  21 A  295  GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR          
SEQRES  22 A  295  GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU          
SEQRES  23 A  295  TRP VAL GLY ALA THR THR ASP TRP SER                          
SEQRES   1 B  264  MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY          
SEQRES   2 B  264  LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER          
SEQRES   3 B  264  LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE          
SEQRES   4 B  264  ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR          
SEQRES   5 B  264  GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG          
SEQRES   6 B  264  VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU          
SEQRES   7 B  264  VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL          
SEQRES   8 B  264  GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP          
SEQRES   9 B  264  LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP          
SEQRES  10 B  264  GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR          
SEQRES  11 B  264  ASP GLY TYR LEU LEU ARG LEU PHE CYS VAL GLY PHE THR          
SEQRES  12 B  264  LYS LYS ARG ASN ASN GLN ILE ARG LYS THR SER TYR ALA          
SEQRES  13 B  264  GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET          
SEQRES  14 B  264  GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS          
SEQRES  15 B  264  GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS          
SEQRES  16 B  264  ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS          
SEQRES  17 B  264  ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO          
SEQRES  18 B  264  LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU          
SEQRES  19 B  264  GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY          
SEQRES  20 B  264  ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL          
SEQRES  21 B  264  GLN GLU SER VAL                                              
SEQRES   1 C  293  MET ALA ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY          
SEQRES   2 C  293  PRO GLY GLY PRO GLY MET GLY ASN ARG GLY GLY PHE ARG          
SEQRES   3 C  293  GLY GLY PHE GLY SER GLY ILE ARG GLY ARG GLY ARG GLY          
SEQRES   4 C  293  ARG GLY ARG GLY ARG GLY ARG GLY ARG GLY ALA ARG GLY          
SEQRES   5 C  293  GLY LYS ALA GLU ASP LYS GLU TRP MET PRO VAL THR LYS          
SEQRES   6 C  293  LEU GLY ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU          
SEQRES   7 C  293  GLU GLU ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER          
SEQRES   8 C  293  GLU ILE ILE ASP PHE PHE LEU GLY ALA SER LEU LYS ASP          
SEQRES   9 C  293  GLU VAL LEU LYS ILE MET PRO VAL GLN LYS GLN THR ARG          
SEQRES  10 C  293  ALA GLY GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE          
SEQRES  11 C  293  GLY ASP TYR ASN GLY HIS VAL GLY LEU GLY VAL LYS CYS          
SEQRES  12 C  293  SER LYS GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE          
SEQRES  13 C  293  LEU ALA LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR          
SEQRES  14 C  293  TRP GLY ASN LYS ILE GLY LYS PRO HIS THR VAL PRO CYS          
SEQRES  15 C  293  LYS VAL THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU          
SEQRES  16 C  293  ILE PRO ALA PRO ARG GLY THR GLY ILE VAL SER ALA PRO          
SEQRES  17 C  293  VAL PRO LYS LYS LEU LEU MET MET ALA GLY ILE ASP ASP          
SEQRES  18 C  293  CYS TYR THR SER ALA ARG GLY CYS THR ALA THR LEU GLY          
SEQRES  19 C  293  ASN PHE ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR          
SEQRES  20 C  293  TYR SER TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL          
SEQRES  21 C  293  PHE THR LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU          
SEQRES  22 C  293  VAL LYS THR HIS THR ARG VAL SER VAL GLN ARG THR GLN          
SEQRES  23 C  293  ALA PRO ALA VAL ALA THR THR                                  
SEQRES   1 D  243  MET ALA VAL GLN ILE SER LYS LYS ARG LYS PHE VAL ALA          
SEQRES   2 D  243  ASP GLY ILE PHE LYS ALA GLU LEU ASN GLU PHE LEU THR          
SEQRES   3 D  243  ARG GLU LEU ALA GLU ASP GLY TYR SER GLY VAL GLU VAL          
SEQRES   4 D  243  ARG VAL THR PRO THR ARG THR GLU ILE ILE ILE LEU ALA          
SEQRES   5 D  243  THR ARG THR GLN ASN VAL LEU GLY GLU LYS GLY ARG ARG          
SEQRES   6 D  243  ILE ARG GLU LEU THR ALA VAL VAL GLN LYS ARG PHE GLY          
SEQRES   7 D  243  PHE PRO GLU GLY SER VAL GLU LEU TYR ALA GLU LYS VAL          
SEQRES   8 D  243  ALA THR ARG GLY LEU CYS ALA ILE ALA GLN ALA GLU SER          
SEQRES   9 D  243  LEU ARG TYR LYS LEU LEU GLY GLY LEU ALA VAL ARG ARG          
SEQRES  10 D  243  ALA CYS TYR GLY VAL LEU ARG PHE ILE MET GLU SER GLY          
SEQRES  11 D  243  ALA LYS GLY CYS GLU VAL VAL VAL SER GLY LYS LEU ARG          
SEQRES  12 D  243  GLY GLN ARG ALA LYS SER MET LYS PHE VAL ASP GLY LEU          
SEQRES  13 D  243  MET ILE HIS SER GLY ASP PRO VAL ASN TYR TYR VAL ASP          
SEQRES  14 D  243  THR ALA VAL ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU          
SEQRES  15 D  243  GLY ILE LYS VAL LYS ILE MET LEU PRO TRP ASP PRO THR          
SEQRES  16 D  243  GLY LYS ILE GLY PRO LYS LYS PRO LEU PRO ASP HIS VAL          
SEQRES  17 D  243  SER ILE VAL GLU PRO LYS ASP GLU ILE LEU PRO THR THR          
SEQRES  18 D  243  PRO ILE SER GLU GLN LYS GLY GLY LYS PRO GLU PRO PRO          
SEQRES  19 D  243  ALA MET PRO GLN PRO VAL PRO THR ALA                          
SEQRES   1 E  263  MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA          
SEQRES   2 E  263  ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR GLY VAL          
SEQRES   3 E  263  PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG          
SEQRES   4 E  263  GLU CYS LEU PRO LEU ILE VAL PHE LEU ARG ASN ARG LEU          
SEQRES   5 E  263  LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS          
SEQRES   6 E  263  MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG VAL          
SEQRES   7 E  263  ASP VAL THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER          
SEQRES   8 E  263  ILE GLU LYS THR GLY GLU HIS PHE ARG LEU VAL TYR ASP          
SEQRES   9 E  263  THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR VAL GLU          
SEQRES  10 E  263  GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE THR          
SEQRES  11 E  263  VAL GLY VAL LYS GLY ILE PRO HIS LEU VAL THR HIS ASP          
SEQRES  12 E  263  ALA ARG THR ILE ARG TYR PRO ASP PRO VAL ILE LYS VAL          
SEQRES  13 E  263  ASN ASP THR VAL GLN ILE ASP LEU GLY THR GLY LYS ILE          
SEQRES  14 E  263  ILE ASN PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET          
SEQRES  15 E  263  VAL ILE GLY GLY ALA ASN LEU GLY ARG VAL GLY VAL ILE          
SEQRES  16 E  263  THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL          
SEQRES  17 E  263  HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG          
SEQRES  18 E  263  LEU SER ASN ILE PHE VAL ILE GLY ASN GLY ASN LYS PRO          
SEQRES  19 E  263  TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR          
SEQRES  20 E  263  VAL ALA GLU GLU ARG ASP LYS ARG LEU ALA THR LYS GLN          
SEQRES  21 E  263  SER SER GLY                                                  
SEQRES   1 F  204  MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU          
SEQRES   2 F  204  THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP          
SEQRES   3 F  204  ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE          
SEQRES   4 F  204  ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER          
SEQRES   5 F  204  ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN          
SEQRES   6 F  204  CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET          
SEQRES   7 F  204  HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG          
SEQRES   8 F  204  ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR          
SEQRES   9 F  204  GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE          
SEQRES  10 F  204  ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG          
SEQRES  11 F  204  ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO          
SEQRES  12 F  204  LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR          
SEQRES  13 F  204  GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE          
SEQRES  14 F  204  ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS          
SEQRES  15 F  204  GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU          
SEQRES  16 F  204  LEU GLU ARG VAL ALA LYS SER ASN ARG                          
SEQRES   1 G  249  MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN          
SEQRES   2 G  249  LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR          
SEQRES   3 G  249  PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP          
SEQRES   4 G  249  ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE          
SEQRES   5 G  249  SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN          
SEQRES   6 G  249  GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER          
SEQRES   7 G  249  LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU          
SEQRES   8 G  249  ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA          
SEQRES   9 G  249  ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY          
SEQRES  10 G  249  GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO          
SEQRES  11 G  249  ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS          
SEQRES  12 G  249  LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR          
SEQRES  13 G  249  VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO          
SEQRES  14 G  249  ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO          
SEQRES  15 G  249  ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS          
SEQRES  16 G  249  LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU          
SEQRES  17 G  249  TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS          
SEQRES  18 G  249  GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU          
SEQRES  19 G  249  SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER          
SEQRES  20 G  249  GLN LYS                                                      
SEQRES   1 H  194  MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY          
SEQRES   2 H  194  GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA          
SEQRES   3 H  194  LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN          
SEQRES   4 H  194  LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU          
SEQRES   5 H  194  VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO          
SEQRES   6 H  194  VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG          
SEQRES   7 H  194  LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS          
SEQRES   8 H  194  VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO          
SEQRES   9 H  194  THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO          
SEQRES  10 H  194  ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU          
SEQRES  11 H  194  GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG          
SEQRES  12 H  194  ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL          
SEQRES  13 H  194  HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS          
SEQRES  14 H  194  VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY          
SEQRES  15 H  194  LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU              
SEQRES   1 I  208  MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS          
SEQRES   2 I  208  THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS          
SEQRES   3 I  208  TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY          
SEQRES   4 I  208  PRO ARG ARG ILE HIS THR VAL ARG VAL ARG GLY GLY ASN          
SEQRES   5 I  208  LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE          
SEQRES   6 I  208  SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE          
SEQRES   7 I  208  ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL          
SEQRES   8 I  208  ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE          
SEQRES   9 I  208  ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR          
SEQRES  10 I  208  ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR          
SEQRES  11 I  208  PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS          
SEQRES  12 I  208  LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA          
SEQRES  13 I  208  LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY          
SEQRES  14 I  208  LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS          
SEQRES  15 I  208  GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU          
SEQRES  16 I  208  GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS          
SEQRES   1 J  194  MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR          
SEQRES   2 J  194  VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP          
SEQRES   3 J  194  GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN          
SEQRES   4 J  194  LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS          
SEQRES   5 J  194  ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU          
SEQRES   6 J  194  LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU          
SEQRES   7 J  194  ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS          
SEQRES   8 J  194  MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP          
SEQRES   9 J  194  PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU          
SEQRES  10 J  194  GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE          
SEQRES  11 J  194  ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN          
SEQRES  12 J  194  ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS          
SEQRES  13 J  194  ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG          
SEQRES  14 J  194  PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN          
SEQRES  15 J  194  GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP              
SEQRES   1 K  165  MET LEU MET PRO LYS LYS ASN ARG ILE ALA ILE TYR GLU          
SEQRES   2 K  165  LEU LEU PHE LYS GLU GLY VAL MET VAL ALA LYS LYS ASP          
SEQRES   3 K  165  VAL HIS MET PRO LYS HIS PRO GLU LEU ALA ASP LYS ASN          
SEQRES   4 K  165  VAL PRO ASN LEU HIS VAL MET LYS ALA MET GLN SER LEU          
SEQRES   5 K  165  LYS SER ARG GLY TYR VAL LYS GLU GLN PHE ALA TRP ARG          
SEQRES   6 K  165  HIS PHE TYR TRP TYR LEU THR ASN GLU GLY ILE GLN TYR          
SEQRES   7 K  165  LEU ARG ASP TYR LEU HIS LEU PRO PRO GLU ILE VAL PRO          
SEQRES   8 K  165  ALA THR LEU ARG ARG SER ARG PRO GLU THR GLY ARG PRO          
SEQRES   9 K  165  ARG PRO LYS GLY LEU GLU GLY GLU ARG PRO ALA ARG LEU          
SEQRES  10 K  165  THR ARG GLY GLU ALA ASP ARG ASP THR TYR ARG ARG SER          
SEQRES  11 K  165  ALA VAL PRO PRO GLY ALA ASP LYS LYS ALA GLU ALA GLY          
SEQRES  12 K  165  ALA GLY SER ALA THR GLU PHE GLN PHE ARG GLY GLY PHE          
SEQRES  13 K  165  GLY ARG GLY ARG GLY GLN PRO PRO GLN                          
SEQRES   1 L  158  MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN          
SEQRES   2 L  158  PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY          
SEQRES   3 L  158  GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN          
SEQRES   4 L  158  ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU          
SEQRES   5 L  158  GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN          
SEQRES   6 L  158  VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR          
SEQRES   7 L  158  LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP          
SEQRES   8 L  158  TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS          
SEQRES   9 L  158  ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE          
SEQRES  10 L  158  ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU          
SEQRES  11 L  158  CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU          
SEQRES  12 L  158  LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN          
SEQRES  13 L  158  LYS PHE                                                      
SEQRES   1 M  132  MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP          
SEQRES   2 M  132  VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU          
SEQRES   3 M  132  ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA          
SEQRES   4 M  132  LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU          
SEQRES   5 M  132  ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL          
SEQRES   6 M  132  GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS          
SEQRES   7 M  132  VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU          
SEQRES   8 M  132  CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL          
SEQRES   9 M  132  GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU          
SEQRES  10 M  132  SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS          
SEQRES  11 M  132  LYS LYS                                                      
SEQRES   1 N  151  MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN          
SEQRES   2 N  151  SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU          
SEQRES   3 N  151  LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS          
SEQRES   4 N  151  LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL          
SEQRES   5 N  151  ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE          
SEQRES   6 N  151  VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS          
SEQRES   7 N  151  GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU          
SEQRES   8 N  151  ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG          
SEQRES   9 N  151  ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU          
SEQRES  10 N  151  ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS          
SEQRES  11 N  151  THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER          
SEQRES  12 N  151  SER THR ALA SER ALA LEU VAL ALA                              
SEQRES   1 O  151  MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN          
SEQRES   2 O  151  VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN          
SEQRES   3 O  151  VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP          
SEQRES   4 O  151  THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR          
SEQRES   5 O  151  ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP          
SEQRES   6 O  151  ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA          
SEQRES   7 O  151  GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR          
SEQRES   8 O  151  ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG          
SEQRES   9 O  151  THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG          
SEQRES  10 O  151  ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU          
SEQRES  11 O  151  ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS          
SEQRES  12 O  151  GLY GLY ARG ARG GLY ARG ARG LEU                              
SEQRES   1 P  145  MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG          
SEQRES   2 P  145  LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU          
SEQRES   3 P  145  ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA          
SEQRES   4 P  145  ARG GLN ARG ARG ARG LEU ASN ARG GLY LEU ARG ARG LYS          
SEQRES   5 P  145  GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS          
SEQRES   6 P  145  GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR          
SEQRES   7 P  145  HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY          
SEQRES   8 P  145  SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN          
SEQRES   9 P  145  VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY          
SEQRES  10 P  145  GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG          
SEQRES  11 P  145  PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO          
SEQRES  12 P  145  LEU LYS                                                      
SEQRES   1 Q  146  MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE          
SEQRES   2 Q  146  GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS          
SEQRES   3 Q  146  ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU          
SEQRES   4 Q  146  GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU          
SEQRES   5 Q  146  GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY          
SEQRES   6 Q  146  VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL          
SEQRES   7 Q  146  ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA          
SEQRES   8 Q  146  LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER          
SEQRES   9 Q  146  LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG          
SEQRES  10 Q  146  THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS          
SEQRES  11 Q  146  LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS          
SEQRES  12 Q  146  SER TYR ARG                                                  
SEQRES   1 R  135  MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA          
SEQRES   2 R  135  ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN          
SEQRES   3 R  135  ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA          
SEQRES   4 R  135  ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY          
SEQRES   5 R  135  TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO          
SEQRES   6 R  135  VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG          
SEQRES   7 R  135  GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU          
SEQRES   8 R  135  ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU          
SEQRES   9 R  135  MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU          
SEQRES  10 R  135  GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR          
SEQRES  11 R  135  PRO ARG GLY PRO VAL                                          
SEQRES   1 S  152  MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU          
SEQRES   2 S  152  ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE          
SEQRES   3 S  152  ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG          
SEQRES   4 S  152  TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU          
SEQRES   5 S  152  THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU          
SEQRES   6 S  152  ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS          
SEQRES   7 S  152  ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS          
SEQRES   8 S  152  ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP          
SEQRES   9 S  152  ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE          
SEQRES  10 S  152  ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG          
SEQRES  11 S  152  VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY          
SEQRES  12 S  152  ARG THR VAL GLY VAL SER LYS LYS LYS                          
SEQRES   1 T  145  MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU          
SEQRES   2 T  145  PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY          
SEQRES   3 T  145  LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU          
SEQRES   4 T  145  ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP          
SEQRES   5 T  145  PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR          
SEQRES   6 T  145  LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE          
SEQRES   7 T  145  TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS          
SEQRES   8 T  145  PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU          
SEQRES   9 T  145  GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN          
SEQRES  10 T  145  ASP GLY GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP          
SEQRES  11 T  145  LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA ASN LYS          
SEQRES  12 T  145  LYS HIS                                                      
SEQRES   1 U  119  MET ALA PHE LYS ASP THR GLY LYS THR PRO VAL GLU PRO          
SEQRES   2 U  119  GLU VAL ALA ILE HIS ARG ILE ARG ILE THR LEU THR SER          
SEQRES   3 U  119  ARG ASN VAL LYS SER LEU GLU LYS VAL CYS ALA ASP LEU          
SEQRES   4 U  119  ILE ARG GLY ALA LYS GLU LYS ASN LEU LYS VAL LYS GLY          
SEQRES   5 U  119  PRO VAL ARG MET PRO THR LYS THR LEU ARG ILE THR THR          
SEQRES   6 U  119  ARG LYS THR PRO CYS GLY GLU GLY SER LYS THR TRP ASP          
SEQRES   7 U  119  ARG PHE GLN MET ARG ILE HIS LYS ARG LEU ILE ASP LEU          
SEQRES   8 U  119  HIS SER PRO SER GLU ILE VAL LYS GLN ILE THR SER ILE          
SEQRES   9 U  119  SER ILE GLU PRO GLY VAL GLU VAL GLU VAL THR ILE ALA          
SEQRES  10 U  119  ASP ALA                                                      
SEQRES   1 V   83  MET GLN ASN ASP ALA GLY GLU PHE VAL ASP LEU TYR VAL          
SEQRES   2 V   83  PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA          
SEQRES   3 V   83  LYS ASP HIS ALA SER ILE GLN MET ASN VAL ALA GLU VAL          
SEQRES   4 V   83  ASP LYS VAL THR GLY ARG PHE ASN GLY GLN PHE LYS THR          
SEQRES   5 V   83  TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER          
SEQRES   6 V   83  ASP ASP SER ILE LEU ARG LEU ALA LYS ALA ASP GLY ILE          
SEQRES   7 V   83  VAL SER LYS ASN PHE                                          
SEQRES   1 W  130  MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER          
SEQRES   2 W  130  ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU          
SEQRES   3 W  130  ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR          
SEQRES   4 W  130  VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE          
SEQRES   5 W  130  ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU          
SEQRES   6 W  130  THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG          
SEQRES   7 W  130  PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN          
SEQRES   8 W  130  ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU          
SEQRES   9 W  130  THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG          
SEQRES  10 W  130  ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE          
SEQRES   1 X  143  MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU          
SEQRES   2 X  143  ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN          
SEQRES   3 X  143  TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN          
SEQRES   4 X  143  PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU          
SEQRES   5 X  143  GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA          
SEQRES   6 X  143  ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY          
SEQRES   7 X  143  LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU          
SEQRES   8 X  143  ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY          
SEQRES   9 X  143  PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY          
SEQRES  10 X  143  VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU          
SEQRES  11 X  143  LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER          
SEQRES   1 Y  133  MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET          
SEQRES   2 Y  133  THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP          
SEQRES   3 Y  133  VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU          
SEQRES   4 Y  133  ILE ARG GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO          
SEQRES   5 Y  133  ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY          
SEQRES   6 Y  133  GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER          
SEQRES   7 Y  133  LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU          
SEQRES   8 Y  133  ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG          
SEQRES   9 Y  133  LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL          
SEQRES  10 Y  133  ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS          
SEQRES  11 Y  133  PRO LYS GLU                                                  
SEQRES   1 Z  125  MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY          
SEQRES   2 Z  125  LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER          
SEQRES   3 Z  125  GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS          
SEQRES   4 Z  125  VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS          
SEQRES   5 Z  125  ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR          
SEQRES   6 Z  125  LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS          
SEQRES   7 Z  125  ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU          
SEQRES   8 Z  125  LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG          
SEQRES   9 Z  125  ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP          
SEQRES  10 Z  125  ALA PRO ALA ALA GLY GLU ASP ALA                              
SEQRES   1 a  115  MET THR LYS LYS ARG ARG ASN ASN GLY ARG ALA LYS LYS          
SEQRES   2 a  115  GLY ARG GLY HIS VAL GLN PRO ILE ARG CYS THR ASN CYS          
SEQRES   3 a  115  ALA ARG CYS VAL PRO LYS ASP LYS ALA ILE LYS LYS PHE          
SEQRES   4 a  115  VAL ILE ARG ASN ILE VAL GLU ALA ALA ALA VAL ARG ASP          
SEQRES   5 a  115  ILE SER GLU ALA SER VAL PHE ASP ALA TYR VAL LEU PRO          
SEQRES   6 a  115  LYS LEU TYR VAL LYS LEU HIS TYR CYS VAL SER CYS ALA          
SEQRES   7 a  115  ILE HIS SER LYS VAL VAL ARG ASN ARG SER ARG GLU ALA          
SEQRES   8 a  115  ARG LYS ASP ARG THR PRO PRO PRO ARG PHE ARG PRO ALA          
SEQRES   9 a  115  GLY ALA ALA PRO ARG PRO PRO PRO LYS PRO MET                  
SEQRES   1 b   84  MET PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU          
SEQRES   2 b   84  GLU GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN          
SEQRES   3 b   84  SER PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY          
SEQRES   4 b   84  CYS TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR          
SEQRES   5 b   84  VAL VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN          
SEQRES   6 b   84  PRO THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER          
SEQRES   7 b   84  PHE ARG ARG LYS GLN HIS                                      
SEQRES   1 c   69  MET ASP THR SER ARG VAL GLN PRO ILE LYS LEU ALA ARG          
SEQRES   2 c   69  VAL THR LYS VAL LEU GLY ARG THR GLY SER GLN GLY GLN          
SEQRES   3 c   69  CYS THR GLN VAL ARG VAL GLU PHE MET ASP ASP THR SER          
SEQRES   4 c   69  ARG SER ILE ILE ARG ASN VAL LYS GLY PRO VAL ARG GLU          
SEQRES   5 c   69  GLY ASP VAL LEU THR LEU LEU GLU SER GLU ARG GLU ALA          
SEQRES   6 c   69  ARG ARG LEU ARG                                              
SEQRES   1 d   56  MET GLY HIS GLN GLN LEU TYR TRP SER HIS PRO ARG LYS          
SEQRES   2 d   56  PHE GLY GLN GLY SER ARG SER CYS ARG VAL CYS SER ASN          
SEQRES   3 d   56  ARG HIS GLY LEU ILE ARG LYS TYR GLY LEU ASN MET CYS          
SEQRES   4 d   56  ARG GLN CYS PHE ARG GLN TYR ALA LYS ASP ILE GLY PHE          
SEQRES   5 d   56  ILE LYS LEU ASP                                              
SEQRES   1 e   59  LYS VAL HIS GLY SER LEU ALA ARG ALA GLY LYS VAL ARG          
SEQRES   2 e   59  GLY GLN THR PRO LYS VAL ALA LYS GLN GLU LYS LYS LYS          
SEQRES   3 e   59  LYS LYS THR GLY ARG ALA LYS ARG ARG MET GLN TYR ASN          
SEQRES   4 e   59  ARG ARG PHE VAL ASN VAL VAL PRO THR PHE GLY LYS LYS          
SEQRES   5 e   59  LYS GLY PRO ASN ALA ASN SER                                  
SEQRES   1 f  156  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 f  156  THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN VAL          
SEQRES   3 f  156  LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 f  156  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 f  156  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 f  156  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY ALA LYS          
SEQRES   7 f  156  LYS ARG LYS LYS LYS SER TYR THR THR PRO LYS LYS ASN          
SEQRES   8 f  156  LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU LYS          
SEQRES   9 f  156  TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG LEU          
SEQRES  10 f  156  ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY VAL          
SEQRES  11 f  156  PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY LYS          
SEQRES  12 f  156  CYS CYS LEU THR TYR CYS PHE ASN LYS PRO GLU ASP LYS          
SEQRES   1 g  317  MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY          
SEQRES   2 g  317  HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN          
SEQRES   3 g  317  PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR          
SEQRES   4 g  317  ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR          
SEQRES   5 g  317  GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE          
SEQRES   6 g  317  VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA          
SEQRES   7 g  317  LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP          
SEQRES   8 g  317  LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS          
SEQRES   9 g  317  THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN          
SEQRES  10 g  317  ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS          
SEQRES  11 g  317  LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN          
SEQRES  12 g  317  ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE          
SEQRES  13 g  317  SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY          
SEQRES  14 g  317  TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS          
SEQRES  15 g  317  LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU          
SEQRES  16 g  317  ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA          
SEQRES  17 g  317  SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU          
SEQRES  18 g  317  ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP          
SEQRES  19 g  317  ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP          
SEQRES  20 g  317  LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP          
SEQRES  21 g  317  LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU          
SEQRES  22 g  317  VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS          
SEQRES  23 g  317  THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE          
SEQRES  24 g  317  ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL          
SEQRES  25 g  317  THR ILE GLY THR ARG                                          
SEQRES   1 h  436  PRO SER ALA ALA ASP ARG ASN VAL GLU ILE TRP LYS ILE          
SEQRES   2 h  436  LYS LYS LEU ILE LYS SER LEU GLU ALA ALA ARG GLY ASN          
SEQRES   3 h  436  GLY THR SER MET ILE SER LEU ILE ILE PRO PRO LYS ASP          
SEQRES   4 h  436  GLN ILE SER ARG VAL ALA LYS MET LEU ALA ASP GLU PHE          
SEQRES   5 h  436  GLY THR ALA SER ASN ILE LYS SER ARG VAL ASN ARG LEU          
SEQRES   6 h  436  SER VAL LEU GLY ALA ILE THR SER VAL GLN GLN ARG LEU          
SEQRES   7 h  436  LYS LEU TYR ASN LYS VAL PRO PRO ASN GLY LEU VAL VAL          
SEQRES   8 h  436  TYR CYS GLY THR ILE VAL THR GLU GLU GLY LYS GLU LYS          
SEQRES   9 h  436  LYS VAL ASN ILE ASP PHE GLU PRO PHE LYS PRO ILE ASN          
SEQRES  10 h  436  THR SER LEU TYR LEU CYS ASP ASN LYS PHE HIS THR GLU          
SEQRES  11 h  436  ALA LEU THR ALA LEU LEU SER ASP ASP SER LYS PHE GLY          
SEQRES  12 h  436  PHE ILE VAL ILE ASP GLY SER GLY ALA LEU PHE GLY THR          
SEQRES  13 h  436  LEU GLN GLY ASN THR ARG GLU VAL LEU HIS LYS PHE THR          
SEQRES  14 h  436  VAL ASP LEU PRO LYS LYS HIS GLY ARG GLY GLY GLN SER          
SEQRES  15 h  436  ALA LEU ARG PHE ALA ARG LEU ARG MET GLU LYS ARG HIS          
SEQRES  16 h  436  ASN TYR VAL ARG LYS VAL ALA GLU THR ALA VAL GLN LEU          
SEQRES  17 h  436  PHE ILE SER GLY ASP LYS VAL ASN VAL ALA GLY LEU VAL          
SEQRES  18 h  436  LEU ALA GLY SER ALA ASP PHE LYS THR GLU LEU SER GLN          
SEQRES  19 h  436  SER ASP MET PHE ASP GLN ARG LEU GLN SER LYS VAL LEU          
SEQRES  20 h  436  LYS LEU VAL ASP ILE SER TYR GLY GLY GLU ASN GLY PHE          
SEQRES  21 h  436  ASN GLN ALA ILE GLU LEU SER THR GLU VAL LEU SER ASN          
SEQRES  22 h  436  VAL LYS PHE ILE GLN GLU LYS LYS LEU ILE GLY ARG TYR          
SEQRES  23 h  436  PHE ASP GLU ILE SER GLN ASP THR GLY LYS TYR CYS PHE          
SEQRES  24 h  436  GLY VAL GLU ASP THR LEU LYS ALA LEU GLU MET GLY ALA          
SEQRES  25 h  436  VAL GLU ILE LEU ILE VAL TYR GLU ASN LEU ASP ILE MET          
SEQRES  26 h  436  ARG TYR VAL LEU HIS CYS GLN GLY THR GLU GLU GLU LYS          
SEQRES  27 h  436  ILE LEU TYR LEU THR PRO GLU GLN GLU LYS ASP LYS SER          
SEQRES  28 h  436  HIS PHE THR ASP LYS GLU THR GLY GLN GLU HIS GLU LEU          
SEQRES  29 h  436  ILE GLU SER MET PRO LEU LEU GLU TRP PHE ALA ASN ASN          
SEQRES  30 h  436  TYR LYS LYS PHE GLY ALA THR LEU GLU ILE VAL THR ASP          
SEQRES  31 h  436  LYS SER GLN GLU GLY SER GLN PHE VAL LYS GLY PHE GLY          
SEQRES  32 h  436  GLY ILE GLY GLY ILE LEU ARG TYR ARG VAL ASP PHE GLN          
SEQRES  33 h  436  GLY MET GLU TYR GLN GLY GLY ASP ASP GLU PHE PHE ASP          
SEQRES  34 h  436  LEU ASP ASP TYR LEU GLU HIS                                  
SEQRES   1 i  426  LYS GLU HIS VAL ASN VAL VAL PHE ILE GLY HIS VAL ASP          
SEQRES   2 i  426  ALA GLY LYS SER THR ILE GLY GLY GLN ILE MET TYR LEU          
SEQRES   3 i  426  THR GLY MET VAL ASP LYS ARG THR LEU GLU LYS TYR GLU          
SEQRES   4 i  426  ARG GLU ALA LYS GLU LYS ASN ARG GLU THR TRP TYR LEU          
SEQRES   5 i  426  SER TRP ALA LEU ASP THR ASN GLN GLU GLU ARG ASP LYS          
SEQRES   6 i  426  GLY LYS THR VAL GLU VAL GLY ARG ALA TYR PHE GLU THR          
SEQRES   7 i  426  GLU LYS LYS HIS PHE THR ILE LEU ASP ALA PRO GLY HIS          
SEQRES   8 i  426  LYS SER PHE VAL PRO ASN MET ILE GLY GLY ALA SER GLN          
SEQRES   9 i  426  ALA ASP LEU ALA VAL LEU VAL ILE SER ALA ARG LYS GLY          
SEQRES  10 i  426  GLU PHE GLU THR GLY PHE GLU LYS GLY GLY GLN THR ARG          
SEQRES  11 i  426  GLU HIS ALA MET LEU ALA LYS THR ALA GLY VAL LYS HIS          
SEQRES  12 i  426  LEU ILE VAL LEU ILE ASN LYS MET ASP ASP PRO THR VAL          
SEQRES  13 i  426  ASN TRP SER ASN GLU ARG TYR GLU GLU CYS LYS GLU LYS          
SEQRES  14 i  426  LEU VAL PRO PHE LEU LYS LYS VAL GLY PHE ASN PRO LYS          
SEQRES  15 i  426  LYS ASP ILE HIS PHE MET PRO CYS SER GLY LEU THR GLY          
SEQRES  16 i  426  ALA ASN LEU LYS GLU GLN SER ASP PHE CYS PRO TRP TYR          
SEQRES  17 i  426  ILE GLY LEU PRO PHE ILE PRO TYR LEU ASP ASN LEU PRO          
SEQRES  18 i  426  ASN PHE ASN ARG SER VAL ASP GLY PRO ILE ARG LEU PRO          
SEQRES  19 i  426  ILE VAL ASP LYS TYR LYS ASP MET GLY THR VAL VAL LEU          
SEQRES  20 i  426  GLY LYS LEU GLU SER GLY SER ILE CYS LYS GLY GLN GLN          
SEQRES  21 i  426  LEU VAL MET MET PRO ASN LYS HIS ASN VAL GLU VAL LEU          
SEQRES  22 i  426  GLY ILE LEU SER ASP ASP VAL GLU THR ASP THR VAL ALA          
SEQRES  23 i  426  PRO GLY GLU ASN LEU LYS ILE ARG LEU LYS GLY ILE GLU          
SEQRES  24 i  426  GLU GLU GLU ILE LEU PRO GLY PHE ILE LEU CYS ASP PRO          
SEQRES  25 i  426  ASN ASN LEU CYS HIS SER GLY ARG THR PHE ASP ALA GLN          
SEQRES  26 i  426  ILE VAL ILE ILE GLU HIS LYS SER ILE ILE CYS PRO GLY          
SEQRES  27 i  426  TYR ASN ALA VAL LEU HIS ILE HIS THR CYS ILE GLU GLU          
SEQRES  28 i  426  VAL GLU ILE THR ALA LEU ILE CYS LEU VAL ASP LYS LYS          
SEQRES  29 i  426  SER GLY GLU LYS SER LYS THR ARG PRO ARG PHE VAL LYS          
SEQRES  30 i  426  GLN ASP GLN VAL CYS ILE ALA ARG LEU ARG THR ALA GLY          
SEQRES  31 i  426  THR ILE CYS LEU GLU THR PHE LYS ASP PHE PRO GLN MET          
SEQRES  32 i  426  GLY ARG PHE THR LEU ARG ASP GLU GLY LYS THR ILE ALA          
SEQRES  33 i  426  ILE GLY LYS VAL LEU LYS LEU VAL PRO GLU                      
SEQRES   1 j  201    A   A   A   A   A   U   G   U   G   A   U   C   U          
SEQRES   2 j  201    U   G   C   U   U   G   U   A   A   A   U   A   C          
SEQRES   3 j  201    A   A   U   U   U   U   G   A   G   A   G   G   U          
SEQRES   4 j  201    U   A   A   U   A   A   A   U   U   A   C   A   A          
SEQRES   5 j  201    G   U   A   G   U   G   C   U   A   U   U   U   U          
SEQRES   6 j  201    U   G   U   A   U   U   U   A   G   G   U   U   A          
SEQRES   7 j  201    G   C   U   A   U   U   U   A   G   C   U   U   U          
SEQRES   8 j  201    A   C   G   U   U   C   C   A   G   G   A   U   G          
SEQRES   9 j  201    C   C   U   A   G   U   G   G   C   A   G   C   C          
SEQRES  10 j  201    C   C   A   C   A   A   U   A   U   C   C   A   G          
SEQRES  11 j  201    G   A   A   G   C   C   C   U   C   U   C   U   G          
SEQRES  12 j  201    C   G   G   U   U   A   U   U   C   A   G   A   U          
SEQRES  13 j  201    U   A   G   G   U   A   G   U   C   G   A   A   A          
SEQRES  14 j  201    A   A   C   C   U   A   A   G   A   A   A   U   U          
SEQRES  15 j  201    U   A   C   C   U   U   A   A   G   G   C   U   U          
SEQRES  16 j  201    C   C   U   C   G   A                                      
HELIX    1   1 LYS A   11  GLY A   22  1                                  12    
HELIX    2   2 ASN A   50  VAL A   66  1                                  17    
HELIX    3   3 ASN A   70  ALA A   72  5                                   3    
HELIX    4   4 ARG A   80  THR A   94  1                                  15    
HELIX    5   5 ASP A  130  ASN A  141  1                                  12    
HELIX    6   6 GLY A  167  GLY A  187  1                                  21    
HELIX    7   7 MET A  198  TYR A  202  5                                   5    
HELIX    8   8 ARG A  205  GLU A  219  1                                  15    
HELIX    9   9 ILE B   57  LYS B   63  1                                   7    
HELIX   10  10 LEU B   71  ASN B   76  1                                   6    
HELIX   11  11 THR B  106  VAL B  114  1                                   9    
HELIX   12  12 HIS B  158  VAL B  176  1                                  19    
HELIX   13  13 ASN B  179  ILE B  189  1                                  11    
HELIX   14  14 ASP B  191  GLN B  202  1                                  12    
HELIX   15  15 GLU B  224  MET B  229  1                                   6    
HELIX   16  16 GLU B  230  HIS B  232  5                                   3    
HELIX   17  17 THR C   64  ASP C   72  1                                   9    
HELIX   18  18 SER C   77  SER C   85  1                                   9    
HELIX   19  19 SER C   91  LEU C   98  1                                   8    
HELIX   20  20 GLY C   99  LEU C  102  5                                   4    
HELIX   21  21 GLU C  146  SER C  161  1                                  16    
HELIX   22  22 ALA C  207  GLY C  218  1                                  12    
HELIX   23  23 THR C  232  THR C  247  1                                  16    
HELIX   24  24 TYR C  248  TYR C  250  5                                   3    
HELIX   25  25 THR C  252  TRP C  256  5                                   5    
HELIX   26  26 SER C  264  PHE C  269  1                                   6    
HELIX   27  27 PHE C  269  VAL C  274  1                                   6    
HELIX   28  28 SER D    6  LEU D   29  1                                  24    
HELIX   29  29 ARG D   54  GLY D   60  1                                   7    
HELIX   30  30 GLY D   63  GLY D   78  1                                  16    
HELIX   31  31 CYS D   97  GLY D  111  1                                  15    
HELIX   32  32 ALA D  114  GLY D  130  1                                  17    
HELIX   33  33 PRO D  163  TYR D  167  1                                   5    
HELIX   34  34 PRO E   15  MET E   19  5                                   5    
HELIX   35  35 PRO E   43  ASN E   50  1                                   8    
HELIX   36  36 THR E   57  GLN E   67  1                                  11    
HELIX   37  37 THR E  115  LYS E  120  1                                   6    
HELIX   38  38 THR E  247  LEU E  256  1                                  10    
HELIX   39  39 PRO F   67  MET F   77  1                                  11    
HELIX   40  40 HIS F   79  ASN F   83  5                                   5    
HELIX   41  41 LYS F   85  LEU F  103  1                                  19    
HELIX   42  42 ASN F  107  GLY F  120  1                                  14    
HELIX   43  43 SER F  142  ALA F  162  1                                  21    
HELIX   44  44 THR F  168  LYS F  182  1                                  15    
HELIX   45  45 SER F  187  ARG F  204  1                                  18    
HELIX   46  46 LEU G   24  TYR G   28  5                                   5    
HELIX   47  47 ASP G   39  LEU G   41  5                                   3    
HELIX   48  48 ILE G  121  THR G  127  1                                   7    
HELIX   49  49 ARG G  137  ASN G  146  1                                  10    
HELIX   50  50 THR G  181  ARG G  232  1                                  52    
HELIX   51  51 SER H    4  LYS H    7  5                                   4    
HELIX   52  52 ASP H   17  MET H   32  1                                  16    
HELIX   53  53 ASP H   35  ARG H   41  1                                   7    
HELIX   54  54 GLN H   68  ILE H   75  1                                   8    
HELIX   55  55 ILE H   75  PHE H   87  1                                  13    
HELIX   56  56 THR H  121  VAL H  134  1                                  14    
HELIX   57  57 GLN H  162  THR H  181  1                                  20    
HELIX   58  58 ASP I    6  LYS I   10  5                                   5    
HELIX   59  59 ARG I   25  LEU I   29  5                                   5    
HELIX   60  60 ASN I   88  LYS I   94  1                                   7    
HELIX   61  61 SER I  106  ALA I  118  1                                  13    
HELIX   62  62 LYS I  144  ARG I  152  1                                   9    
HELIX   63  63 SER I  159  GLY I  169  1                                  11    
HELIX   64  64 ARG I  178  GLY I  183  1                                   6    
HELIX   65  65 GLU I  191  LYS I  208  1                                  18    
HELIX   66  66 GLU J   21  GLY J   36  1                                  16    
HELIX   67  67 ASN J   39  THR J   62  1                                  24    
HELIX   68  68 ASP J   67  GLY J   85  1                                  19    
HELIX   69  69 ASP J   88  MET J   92  5                                   5    
HELIX   70  70 LYS J   93  LEU J  100  5                                   8    
HELIX   71  71 LYS J  101  ARG J  108  1                                   8    
HELIX   72  72 ARG J  109  LEU J  117  1                                   9    
HELIX   73  73 SER J  122  GLN J  132  1                                  11    
HELIX   74  74 ARG J  150  LYS J  155  1                                   6    
HELIX   75  75 GLY J  171  LYS J  180  1                                  10    
HELIX   76  76 PRO K    4  GLY K   19  1                                  16    
HELIX   77  77 PRO K   41  GLY K   56  1                                  16    
HELIX   78  78 THR K   72  HIS K   84  1                                  13    
HELIX   79  79 ALA L    2  GLU L    7  1                                   6    
HELIX   80  80 GLN L   18  GLY L   26  5                                   9    
HELIX   81  81 PRO L   47  GLU L   52  1                                   6    
HELIX   82  82 VAL M   11  HIS M   28  1                                  18    
HELIX   83  83 GLY M   34  LYS M   44  1                                  11    
HELIX   84  84 MET M   60  HIS M   72  1                                  13    
HELIX   85  85 ASP M   81  GLY M   90  1                                  10    
HELIX   86  86 ALA M  120  TYR M  127  1                                   8    
HELIX   87  87 THR N   29  GLY N   44  1                                  16    
HELIX   88  88 THR N   46  GLY N   59  1                                  14    
HELIX   89  89 GLN N   62  GLY N   68  1                                   7    
HELIX   90  90 LYS N   70  GLY N   79  1                                  10    
HELIX   91  91 PRO N   85  ASN N  105  1                                  21    
HELIX   92  92 ASP N  108  LYS N  132  1                                  25    
HELIX   93  93 SER N  143  ALA N  151  1                                   9    
HELIX   94  94 GLY O   58  VAL O   62  1                                   5    
HELIX   95  95 ASP O   65  SER O   69  5                                   5    
HELIX   96  96 SER O   70  GLY O   89  1                                  20    
HELIX   97  97 PRO O  110  SER O  122  1                                  13    
HELIX   98  98 ASP P   21  ASP P   27  1                                   7    
HELIX   99  99 SER P   29  TYR P   37  1                                   9    
HELIX  100 100 SER P   38  ARG P   47  1                                  10    
HELIX  101 101 GLN P   53  ALA P   67  1                                  15    
HELIX  102 102 LEU P   86  VAL P   90  5                                   5    
HELIX  103 103 LYS P  108  ILE P  112  5                                   5    
HELIX  104 104 TYR P  115  SER P  120  1                                   6    
HELIX  105 105 PRO Q   38  ILE Q   42  5                                   5    
HELIX  106 106 LEU Q   47  GLY Q   59  1                                  13    
HELIX  107 107 LYS Q   60  GLY Q   65  1                                   6    
HELIX  108 108 GLY Q   76  VAL Q  100  1                                  25    
HELIX  109 109 ASP Q  101  ASP Q  116  1                                  16    
HELIX  110 110 THR R    6  TYR R   21  1                                  16    
HELIX  111 111 ASP R   27  ILE R   38  1                                  12    
HELIX  112 112 SER R   43  GLY R   64  1                                  22    
HELIX  113 113 GLU R   75  ASP R   82  1                                   8    
HELIX  114 114 PRO R  100  ASP R  110  1                                  11    
HELIX  115 115 LYS S   25  THR S   31  1                                   7    
HELIX  116 116 GLY S   37  ASP S   49  1                                  13    
HELIX  117 117 THR S   60  ASN S   73  1                                  14    
HELIX  118 118 ASN S   73  LYS S   78  1                                   6    
HELIX  119 119 PRO S   80  LEU S   84  5                                   5    
HELIX  120 120 LEU S   99  ARG S  118  1                                  20    
HELIX  121 121 ALA S  119  GLY S  128  1                                  10    
HELIX  122 122 THR T    5  VAL T    9  5                                   5    
HELIX  123 123 ASN T   10  GLY T   26  1                                  17    
HELIX  124 124 PRO T   31  THR T   36  1                                   6    
HELIX  125 125 ASN T   51  ARG T   67  1                                  17    
HELIX  126 126 GLY T   71  TYR T   79  1                                   9    
HELIX  127 127 SER T   96  LEU T  110  1                                  15    
HELIX  128 128 THR T  124  LYS T  144  1                                  21    
HELIX  129 129 ASN U   28  LYS U   46  1                                  19    
HELIX  130 130 PRO U   94  SER U  103  1                                  10    
HELIX  131 131 CYS V   56  GLY V   63  1                                   8    
HELIX  132 132 GLU V   64  ASP V   76  1                                  13    
HELIX  133 133 ASN W    5  GLY W   21  1                                  17    
HELIX  134 134 SER W   31  GLY W   45  1                                  15    
HELIX  135 135 GLN W   82  LYS W   84  5                                   3    
HELIX  136 136 ASP W   85  LEU W   94  1                                  10    
HELIX  137 137 HIS W  113  HIS W  120  1                                   8    
HELIX  138 138 THR X    9  TRP X   22  1                                  14    
HELIX  139 139 ASP X   24  LEU X   32  1                                   9    
HELIX  140 140 GLY X   33  ALA X   38  1                                   6    
HELIX  141 141 GLY X   89  ILE X   94  1                                   6    
HELIX  142 142 LEU X  130  LYS X  135  1                                   6    
HELIX  143 143 PRO Y   36  TYR Y   48  1                                  13    
HELIX  144 144 THR Y   51  ASP Y   53  5                                   3    
HELIX  145 145 SER Y   78  GLU Y   86  1                                   9    
HELIX  146 146 PRO Y   87  GLY Y   95  1                                   9    
HELIX  147 147 SER Y  103  LYS Y  116  1                                  14    
HELIX  148 148 ARG Y  118  ALA Y  123  1                                   6    
HELIX  149 149 ASP Z   51  GLU Z   61  1                                  11    
HELIX  150 150 THR Z   69  LYS Z   78  1                                  10    
HELIX  151 151 ARG Z   80  LYS Z   94  1                                  15    
HELIX  152 152 GLU a   46  ALA a   56  1                                  11    
HELIX  153 153 CYS a   74  ILE a   79  1                                   6    
HELIX  154 154 SER b   11  LYS b   18  1                                   8    
HELIX  155 155 HIS b   19  ARG b   23  5                                   5    
HELIX  156 156 GLY d   15  ARG d   19  5                                   5    
HELIX  157 157 CYS d   39  GLY d   51  1                                  13    
HELIX  158 158 GLY e   10  GLN e   15  1                                   6    
HELIX  159 159 ALA e   32  PHE e   42  1                                  11    
HELIX  160 160 ASP h    9  ALA h   27  1                                  19    
HELIX  161 161 GLN h   44  LYS h   63  1                                  20    
HELIX  162 162 SER h   64  TYR h   85  1                                  22    
HELIX  163 163 GLU h  103  GLY h  105  5                                   3    
HELIX  164 164 HIS h  132  LEU h  140  1                                   9    
HELIX  165 165 SER h  186  LEU h  193  1                                   8    
HELIX  166 166 LEU h  193  ILE h  214  1                                  22    
HELIX  167 167 ASP h  231  GLN h  238  1                                   8    
HELIX  168 168 GLN h  244  VAL h  250  1                                   7    
HELIX  169 169 GLU h  261  THR h  272  1                                  12    
HELIX  170 170 LYS h  279  GLN h  296  1                                  18    
HELIX  171 171 GLY h  304  GLY h  315  1                                  12    
HELIX  172 172 THR h  347  GLU h  349  5                                   3    
HELIX  173 173 GLN h  350  THR h  358  1                                   9    
HELIX  174 174 PRO h  373  GLY h  386  1                                  14    
HELIX  175 175 SER h  396  GLY h  407  1                                  12    
HELIX  176 176 ASP h  433  HIS h  440  1                                   8    
HELIX  177 177 GLY i  215  THR i  227  1                                  13    
HELIX  178 178 ASP i  231  LYS i  245  1                                  15    
HELIX  179 179 ARG i  247  TRP i  254  1                                   8    
HELIX  180 180 THR i  258  LYS i  265  1                                   8    
HELIX  181 181 PHE i  294  ALA i  302  1                                   9    
HELIX  182 182 ARG i  315  LYS i  325  1                                  11    
HELIX  183 183 GLN i  328  ALA i  339  1                                  12    
HELIX  184 184 GLU i  361  LYS i  369  1                                   9    
HELIX  185 185 VAL i  371  VAL i  377  1                                   7    
HELIX  186 186 GLY i  378  ASP i  384  1                                   7    
HELIX  187 187 PRO i  412  LEU i  420  1                                   9    
SHEET    1  AA 2 ILE A  38  ARG A  41  0                                        
SHEET    2  AA 2 TYR A  47  ILE A  49 -1  O  ILE A  48   N  TYR A  39           
SHEET    1  AB 5 THR A  97  ALA A 100  0                                        
SHEET    2  AB 5 VAL A  74  SER A  78  1  O  VAL A  76   N  ILE A  99           
SHEET    3  AB 5 LEU A 121  VAL A 124  1  O  LEU A 121   N  SER A  75           
SHEET    4  AB 5 THR A 144  CYS A 148  1  O  ILE A 145   N  VAL A 124           
SHEET    5  AB 5 ILE A 159  PRO A 162  1  O  ILE A 159   N  ALA A 146           
SHEET    1  BA 2 TRP B  30  LYS B  34  0                                        
SHEET    2  BA 2 ASN B  43  LEU B  48 -1  N  ILE B  44   O  VAL B  33           
SHEET    1  BB 6 VAL B  66  SER B  70  0                                        
SHEET    2  BB 6 LYS B  83  ILE B  87 -1  O  PHE B  84   N  VAL B  69           
SHEET    3  BB 6 ASN B  99  ASP B 104 -1  O  ASN B  99   N  ILE B  87           
SHEET    4  BB 6 VAL B 215  LYS B 219 -1  O  VAL B 215   N  MET B 103           
SHEET    5  BB 6 LEU B 134  PHE B 142 -1  O  LEU B 134   N  LEU B 218           
SHEET    6  BB 6 HIS B 208  PHE B 211 -1  O  HIS B 208   N  PHE B 142           
SHEET    1  BC 6 VAL B  66  SER B  70  0                                        
SHEET    2  BC 6 LYS B  83  ILE B  87 -1  O  PHE B  84   N  VAL B  69           
SHEET    3  BC 6 ASN B  99  ASP B 104 -1  O  ASN B  99   N  ILE B  87           
SHEET    4  BC 6 VAL B 215  LYS B 219 -1  O  VAL B 215   N  MET B 103           
SHEET    5  BC 6 LEU B 134  PHE B 142 -1  O  LEU B 134   N  LEU B 218           
SHEET    6  BC 6 MET B 120  LYS B 128 -1  O  ILE B 121   N  GLY B 141           
SHEET    1  BD 2 HIS B 208  PHE B 211  0                                        
SHEET    2  BD 2 LEU B 134  PHE B 142 -1  O  VAL B 140   N  PHE B 211           
SHEET    1  BE 2 VAL B  91  GLN B  92  0                                        
SHEET    2  BE 2 ASN B  95  CYS B  96 -1  O  ASN B  95   N  GLN B  92           
SHEET    1  CA 4 ASP C 104  GLN C 115  0                                        
SHEET    2  CA 4 GLN C 120  ILE C 130 -1  O  ARG C 121   N  LYS C 114           
SHEET    3  CA 4 HIS C 136  SER C 144 -1  O  GLY C 138   N  ILE C 130           
SHEET    4  CA 4 VAL C 163  PRO C 164 -1  O  VAL C 163   N  VAL C 137           
SHEET    1  CB 4 VAL C 184  CYS C 188  0                                        
SHEET    2  CB 4 VAL C 191  ILE C 196 -1  O  VAL C 191   N  CYS C 188           
SHEET    3  CB 4 CYS C 222  ARG C 227 -1  O  TYR C 223   N  ILE C 196           
SHEET    4  CB 4 ILE C 204  VAL C 205  1  O  VAL C 205   N  THR C 224           
SHEET    1  DA 3 TYR D  34  VAL D  41  0                                        
SHEET    2  DA 3 THR D  46  ALA D  52 -1  O  GLU D  47   N  ARG D  40           
SHEET    3  DA 3 VAL D  84  LYS D  90  1  O  GLU D  85   N  ILE D  48           
SHEET    1  DB 4 LYS D 148  GLY D 155  0                                        
SHEET    2  DB 4 GLY D 133  GLY D 140 -1  O  CYS D 134   N  ASP D 154           
SHEET    3  DB 4 VAL D 181  MET D 189 -1  O  GLY D 183   N  SER D 139           
SHEET    4  DB 4 VAL D 168  LEU D 176 -1  O  ASP D 169   N  ILE D 188           
SHEET    1  DC 2 SER D 209  ILE D 210  0                                        
SHEET    2  DC 2 ALA R  39  ILE R  40 -1  O  ILE R  40   N  SER D 209           
SHEET    1  EA 2 LEU E   9  LYS E  10  0                                        
SHEET    2  EA 2 PHE E  27  ALA E  28 -1  O  ALA E  28   N  LEU E   9           
SHEET    1  EB 5 LYS E  75  VAL E  76  0                                        
SHEET    2  EB 5 ILE E  70  ILE E  72 -1  O  ILE E  72   N  LYS E  75           
SHEET    3  EB 5 VAL E  89  ILE E  92 -1  O  SER E  91   N  LYS E  71           
SHEET    4  EB 5 GLU E  97  TYR E 103 -1  O  GLU E  97   N  ILE E  92           
SHEET    5  EB 5 PHE E 109  ILE E 114 -1  O  ALA E 110   N  VAL E 102           
SHEET    1  EC 5 ARG E 145  ARG E 148  0                                        
SHEET    2  EC 5 PRO E 137  THR E 141 -1  O  LEU E 139   N  ILE E 147           
SHEET    3  EC 5 TYR E 121  VAL E 131 -1  N  ARG E 127   O  VAL E 140           
SHEET    4  EC 5 ASP E 158  ASP E 163 -1  O  ASP E 158   N  VAL E 126           
SHEET    5  EC 5 LYS E 168  LYS E 174 -1  O  LYS E 168   N  ASP E 163           
SHEET    1  ED 5 SER E 217  ARG E 221  0                                        
SHEET    2  ED 5 VAL E 207  LYS E 211 -1  O  VAL E 208   N  THR E 220           
SHEET    3  ED 5 VAL E 192  GLU E 199 -1  O  VAL E 194   N  LYS E 211           
SHEET    4  ED 5 LEU E 180  VAL E 183 -1  O  CYS E 181   N  GLY E 193           
SHEET    5  ED 5 ILE E 225  GLY E 229 -1  O  PHE E 226   N  MET E 182           
SHEET    1  FA 6 GLU F 123  ILE F 128  0                                        
SHEET    2  FA 6 ARG F 135  VAL F 141 -1  O  ARG F 135   N  ILE F 128           
SHEET    3  FA 6 SER c  41  LYS c  47  1  O  ASN c  45   N  ASP F 140           
SHEET    4  FA 6 CYS c  27  PHE c  34 -1  O  THR c  28   N  VAL c  46           
SHEET    5  FA 6 ILE c   9  THR c  21 -1  O  ARG c  13   N  GLU c  33           
SHEET    6  FA 6 VAL c  55  LEU c  59 -1  O  LEU c  56   N  ALA c  12           
SHEET    1  GA 5 CYS G  12  GLU G  17  0                                        
SHEET    2  GA 5 LYS G   2  PHE G   7 -1  O  LEU G   3   N  ILE G  16           
SHEET    3  GA 5 VAL G 108  LYS G 115  1  O  LEU G 109   N  ASN G   4           
SHEET    4  GA 5 VAL G  49  ASN G  56 -1  O  VAL G  49   N  VAL G 114           
SHEET    5  GA 5 GLU G  35  ALA G  37 -1  O  VAL G  36   N  VAL G  50           
SHEET    1  GB 2 ARG G  72  LEU G  76  0                                        
SHEET    2  GB 2 ARG G  94  ARG G  98 -1  O  LYS G  95   N  LEU G  75           
SHEET    1  GC 2 LYS G 160  ASN G 163  0                                        
SHEET    2  GC 2 PRO G 169  LYS G 172 -1  O  ARG G 170   N  LEU G 162           
SHEET    1  HA 3 ALA H  47  GLU H  52  0                                        
SHEET    2  HA 3 LYS H  58  PRO H  65 -1  O  ALA H  59   N  ILE H  51           
SHEET    3  HA 3 HIS H  91  GLN H  97  1  O  HIS H  91   N  ILE H  60           
SHEET    1  HB 6 ASP H 184  GLU H 188  0                                        
SHEET    2  HB 6 ARG H 152  LEU H 158  1  O  ARG H 152   N  ASP H 184           
SHEET    3  HB 6 ILE H 139  VAL H 146 -1  N  VAL H 140   O  HIS H 157           
SHEET    4  HB 6 PHE W  50  ILE W  53 -1  O  PHE W  50   N  VAL H 146           
SHEET    5  HB 6 LYS W  60  ASN W  64 -1  O  LYS W  60   N  ILE W  53           
SHEET    6  HB 6 GLN W  24  ILE W  27 -1  O  VAL W  25   N  VAL W  63           
SHEET    1  IA 2 ARG I  42  ARG I  47  0                                        
SHEET    2  IA 2 LYS I  53  ARG I  59 -1  O  LYS I  54   N  VAL I  46           
SHEET    1  IB 6 VAL I  62  TRP I  67  0                                        
SHEET    2  IB 6 CYS I  72  VAL I  81 -1  O  CYS I  72   N  TRP I  67           
SHEET    3  IB 6 ILE I 101  ILE I 104 -1  O  LEU I 103   N  ILE I  79           
SHEET    4  IB 6 LEU I 171  ILE I 175 -1  O  LEU I 171   N  ILE I 104           
SHEET    5  IB 6 ASP I 186  VAL I 189 -1  O  TYR I 188   N  CYS I 174           
SHEET    6  IB 6 VAL I  62  TRP I  67  1  O  ASN I  64   N  GLY I 187           
SHEET    1  JA 3 GLN J 140  VAL J 141  0                                        
SHEET    2  JA 3 ARG J 136  VAL J 137 -1  O  VAL J 137   N  GLN J 140           
SHEET    3  JA 3 ILE J 157  ASP J 158 -1  O  ASP J 158   N  ARG J 136           
SHEET    1  KA 3 VAL K  20  LYS K  24  0                                        
SHEET    2  KA 3 HIS K  66  LEU K  71 -1  O  PHE K  67   N  ALA K  23           
SHEET    3  KA 3 VAL K  58  ALA K  63 -1  O  LYS K  59   N  TYR K  70           
SHEET    1  LA 6 ILE L  68  LYS L  79  0                                        
SHEET    2  LA 6 ILE L 125  CYS L 131 -1  O  VAL L 126   N  GLY L  75           
SHEET    3  LA 6 PHE L 140  VAL L 145 -1  O  ASN L 141   N  GLY L 129           
SHEET    4  LA 6 ARG L 101  HIS L 112  1  O  HIS L 112   N  VAL L 142           
SHEET    5  LA 6 THR L  85  ILE L  96 -1  O  ILE L  86   N  VAL L 111           
SHEET    6  LA 6 ILE L  68  LYS L  79 -1  O  VAL L  76   N  ARG L  89           
SHEET    1  MA 4 LEU M  31  ARG M  33  0                                        
SHEET    2  MA 4 CYS M 108  VAL M 111 -1  O  VAL M 110   N  ALA M  32           
SHEET    3  MA 4 LEU M  49  ALA M  53 -1  O  LEU M  49   N  VAL M 111           
SHEET    4  MA 4 LEU M  76  VAL M  79  1  O  ILE M  77   N  LEU M  52           
SHEET    1  MB 2 CYS M  92  ILE M  94  0                                        
SHEET    2  MB 2 PRO M 100  VAL M 103 -1  N  ARG M 101   O  LYS M  93           
SHEET    1  OA 5 THR O  52  THR O  57  0                                        
SHEET    2  OA 5 THR O  40  THR O  45 -1  O  VAL O  42   N  VAL O  56           
SHEET    3  OA 5 PHE O  28  ALA O  35 -1  O  VAL O  30   N  THR O  45           
SHEET    4  OA 5 ALA O  92  ARG O  98  1  O  ALA O  92   N  GLY O  29           
SHEET    5  OA 5 LYS O 125  ASP O 131  1  O  LYS O 125   N  LEU O  93           
SHEET    1  PA 3 VAL P  76  THR P  78  0                                        
SHEET    2  PA 3 MET P  93  TYR P  97  1  O  MET P  93   N  VAL P  76           
SHEET    3  PA 3 PHE P 102  GLU P 106 -1  O  ASN P 103   N  VAL P  96           
SHEET    1  QA 4 VAL Q  10  LYS Q  16  0                                        
SHEET    2  QA 4 ALA Q  19  ARG Q  27 -1  O  ALA Q  19   N  LYS Q  16           
SHEET    3  QA 4 VAL Q  66  VAL Q  72 -1  O  ASP Q  67   N  LYS Q  26           
SHEET    4  QA 4 LEU Q  31  VAL Q  34  1  O  LEU Q  31   N  ILE Q  68           
SHEET    1  SA 2 ARG S  86  GLN S  87  0                                        
SHEET    2  SA 2 TYR S  95  SER S  96 -1  O  SER S  96   N  ARG S  86           
SHEET    1  TA 2 GLY T  81  GLN T  83  0                                        
SHEET    2  TA 2 HIS T  91  SER T  93 -1  O  HIS T  91   N  GLN T  83           
SHEET    1  TB 2 VAL T 113  LYS T 115  0                                        
SHEET    2  TB 2 ARG T 121  LEU T 123 -1  O  LYS T 122   N  GLU T 114           
SHEET    1  UA 2 LYS U  49  ARG U  55  0                                        
SHEET    2  UA 2 TRP U  77  HIS U  92  1  O  LEU U  88   N  VAL U  54           
SHEET    1  UB 2 LYS U  59  ARG U  66  0                                        
SHEET    2  UB 2 TRP U  77  HIS U  92 -1  O  ASP U  78   N  THR U  65           
SHEET    1  UC 4 VAL U 110  ALA U 117  0                                        
SHEET    2  UC 4 ARG U  19  SER U  26 -1  O  ARG U  19   N  ALA U 117           
SHEET    3  UC 4 TRP U  77  HIS U  92 -1  O  HIS U  85   N  SER U  26           
SHEET    4  UC 4 LYS U  59  ARG U  66 -1  O  LYS U  59   N  ILE U  84           
SHEET    1  UD 4 VAL U 110  ALA U 117  0                                        
SHEET    2  UD 4 ARG U  19  SER U  26 -1  O  ARG U  19   N  ALA U 117           
SHEET    3  UD 4 TRP U  77  HIS U  92 -1  O  HIS U  85   N  SER U  26           
SHEET    4  UD 4 LYS U  49  ARG U  55  1  O  LYS U  49   N  HIS U  92           
SHEET    1  VA 2 ILE V  32  VAL V  39  0                                        
SHEET    2  VA 2 PHE V  46  ILE V  55 -1  N  ASN V  47   O  GLU V  38           
SHEET    1  WA 2 LYS W  71  VAL W  74  0                                        
SHEET    2  WA 2 GLY W 123  PHE W 130 -1  O  PHE W 128   N  GLY W  73           
SHEET    1  WB 2 ASP W  80  VAL W  81  0                                        
SHEET    2  WB 2 GLY W 123  PHE W 130  1  O  GLY W 123   N  VAL W  81           
SHEET    1  WC 4 GLY W 109  ASP W 112  0                                        
SHEET    2  WC 4 PHE W 101  THR W 106 -1  O  LEU W 104   N  MET W 111           
SHEET    3  WC 4 GLY W 123  PHE W 130 -1  O  LYS W 124   N  THR W 105           
SHEET    4  WC 4 ASP W  80  VAL W  81  1  O  VAL W  81   N  GLY W 123           
SHEET    1  WD 4 GLY W 109  ASP W 112  0                                        
SHEET    2  WD 4 PHE W 101  THR W 106 -1  O  LEU W 104   N  MET W 111           
SHEET    3  WD 4 GLY W 123  PHE W 130 -1  O  LYS W 124   N  THR W 105           
SHEET    4  WD 4 LYS W  71  VAL W  74 -1  O  LYS W  71   N  PHE W 130           
SHEET    1  XA 7 HIS X  46  GLU X  58  0                                        
SHEET    2  XA 7 GLU X  99  GLY X 104 -1  O  VAL X 100   N  GLY X  49           
SHEET    3  XA 7 PHE X 120  VAL X 125  0                                        
SHEET    4  XA 7 THR X  82  PHE X  84  1  O  THR X  82   N  PHE X 120           
SHEET    5  XA 7 ILE X  66  LEU X  74 -1  O  VAL X  70   N  ALA X  83           
SHEET    6  XA 7 HIS X  46  GLU X  58  0                                        
SHEET    1  YA 4 THR Y   6  ASN Y  15  0                                        
SHEET    2  YA 4 ARG Y  20  LEU Y  28 -1  O  ARG Y  20   N  ASN Y  15           
SHEET    3  YA 4 LYS Y  68  TYR Y  76 -1  O  THR Y  69   N  VAL Y  27           
SHEET    4  YA 4 ILE Y  55  THR Y  62 -1  O  PHE Y  56   N  MET Y  74           
SHEET    1  ZA 3 LEU Z  67  ILE Z  68  0                                        
SHEET    2  ZA 3 VAL Z 107  ARG Z 111 -1  O  TYR Z 109   N  ILE Z  68           
SHEET    3  ZA 3 ILE Z  97  LYS Z 102 -1  O  LYS Z  98   N  THR Z 110           
SHEET    1  AA 2 PRO a  20  ARG a  22  0                                        
SHEET    2  AA 2 CYS a  29  PRO a  31 -1                                        
SHEET    1  AB 5 VAL a  40  ASN a  43  0                                        
SHEET    2  AB 5 LYS a  66  VAL a  69  1                                        
SHEET    1  BA 2 ILE b  43  PHE b  47  0                                        
SHEET    2  BA 2 PHE b  32  LYS b  36 -1                                        
SHEET    3  BA 2 PHE b  79  ARG b  81 -1  O  ARG b  80   N  ASP b  34           
SHEET    1  BB 6 VAL b  54  LEU b  55  0                                        
SHEET    2  BB 6 VAL b  62  GLN b  65 -1                                        
SHEET    3  BB 6 ARG b  72  LEU b  73 -1                                        
SHEET    1  FA 6 TYR f 106  ASP f 109  0                                        
SHEET    2  FA 6 LYS f 113  ARG f 116 -1                                        
SHEET    1  FB 3 ALA f 133  SER f 134  0                                        
SHEET    2  FB 3 HIS f 139  TYR f 140 -1  O  TYR f 140   N  ALA f 133           
SHEET    3  FB 3 THR f 147  TYR f 148 -1  O  TYR f 148   N  HIS f 139           
SHEET    1  GA 5 GLU g   3  LYS g  12  0                                        
SHEET    2  GA 5 LEU g 306  ILE g 314 -1                                        
SHEET    3  GA 5 THR g 297  GLY g 301  1                                        
SHEET    4  GA 5 SER g 288  TRP g 291 -1                                        
SHEET    1  GB 2 VAL g  18  THR g  23  0                                        
SHEET    2  GB 2 MET g  30  SER g  35 -1                                        
SHEET    3  GB 2 THR g  39  LEU g  45 -1  O  THR g  39   N  SER g  35           
SHEET    4  GB 2 GLY g  53  ARG g  60 -1  O  ILE g  54   N  LYS g  44           
SHEET    1  GC 2 ASP g  68  ILE g  71  0                                        
SHEET    2  GC 2 PHE g  77  GLY g  81 -1                                        
SHEET    3  GC 2 THR g  86  ASP g  91 -1  O  ARG g  88   N  SER g  80           
SHEET    4  GC 2 GLY g  95  VAL g 102 -1  O  GLY g  95   N  ASP g  91           
SHEET    1  GD 4 VAL g 108  PHE g 113  0                                        
SHEET    2  GD 4 ILE g 120  SER g 124 -1  O  VAL g 121   N  ALA g 112           
SHEET    3  GD 4 ILE g 129  TRP g 132 -1  O  LYS g 130   N  SER g 122           
SHEET    4  GD 4 GLN g 143  ASP g 144 -1  O  ASP g 144   N  ILE g 129           
SHEET    1  GE 4 VAL g 151  PHE g 156  0                                        
SHEET    2  GE 4 ILE g 164  GLY g 169 -1  O  VAL g 166   N  ARG g 155           
SHEET    3  GE 4 LEU g 173  ASN g 178 -1  O  LEU g 173   N  GLY g 169           
SHEET    4  GE 4 LYS g 183  ILE g 189 -1  O  LYS g 183   N  ASN g 178           
SHEET    1  GF 4 LEU g 195  VAL g 200  0                                        
SHEET    2  GF 4 LEU g 206  GLY g 211 -1  O  ALA g 208   N  THR g 199           
SHEET    3  GF 4 GLN g 215  ASP g 220 -1  O  MET g 217   N  SER g 209           
SHEET    4  GF 4 LYS g 225  ASP g 231 -1  O  LYS g 225   N  ASP g 220           
SHEET    1  GG 4 ILE g 236  PHE g 241  0                                        
SHEET    2  GG 4 TRP g 247  THR g 252 -1  O  CYS g 249   N  CYS g 240           
SHEET    3  GG 4 ILE g 256  ASP g 260 -1  O  LYS g 257   N  ALA g 250           
SHEET    4  GG 4 ILE g 265  LEU g 270 -1  O  ILE g 265   N  ASP g 260           
SHEET    1  HA 3 GLU h 107  PHE h 114  0                                        
SHEET    2  HA 3 LEU h  93  VAL h 101 -1                                        
SHEET    3  HA 3 MET h  34  ILE h  39  1                                        
SHEET    4  HA 3 LEU h 124  ASP h 128 -1  O  LEU h 124   N  ILE h  38           
SHEET    1  HB 6 THR h 165  PHE h 172  0                                        
SHEET    2  HB 6 ALA h 156  GLN h 162  1                                        
SHEET    3  HB 6 PHE h 146  ILE h 151 -1                                        
SHEET    4  HB 6 VAL h 225  GLY h 228 -1                                        
SHEET    5  HB 6 LEU h 253  ASP h 255 -1                                        
SHEET    1  HC 4 TYR h 301  PHE h 303  0                                        
SHEET    2  HC 4 ILE h 409  LEU h 413 -1  O  GLY h 411   N  CYS h 302           
SHEET    3  HC 4 VAL h 317  TYR h 323 -1  N  GLU h 318   O  ILE h 412           
SHEET    4  HC 4 THR h 388  VAL h 392  1  O  THR h 388   N  LEU h 320           
SHEET    1  HD 2 LEU h 333  HIS h 334  0                                        
SHEET    2  HD 2 GLU h 367  LEU h 368 -1  O  GLU h 367   N  HIS h 334           
SHEET    1  IA 2 ARG i 273  GLU i 277  0                                        
SHEET    2  IA 2 HIS i 282  ALA i 288 -1                                        
SHEET    3  IA 2 HIS i 203  GLY i 210  1  O  VAL i 204   N  THR i 284           
SHEET    4  IA 2 LEU i 307  SER i 313  1  O  LEU i 307   N  VAL i 207           
SHEET    5  IA 2 HIS i 343  ASN i 349  1  O  HIS i 343   N  ALA i 308           
SHEET    6  IA 2 MET i 388  PRO i 389  1  O  MET i 388   N  ILE i 348           
SHEET    1  IB 6 LEU i 433  TYR i 439  0                                        
SHEET    2  IB 6 ILE i 508  CYS i 510 -1                                        
SHEET    3  IB 6 GLN i 460  MET i 463 -1                                        
SHEET    4  IB 6 HIS i 468  SER i 477 -1                                        
SHEET    5  IB 6 VAL i 480  GLU i 481 -1                                        
SHEET    6  IB 6 VAL i 445  LYS i 449  1                                        
SHEET    7  IB 6 ASN i 490  LYS i 496 -1  O  LYS i 492   N  LEU i 476           
SHEET    8  IB 6 LEU i 433  TYR i 439 -1  O  LEU i 433   N  LEU i 509           
SHEET    1  IC 2 ILE i 455  CYS i 456  0                                        
SHEET    2  IC 2 THR i 484  VAL i 485 -1  O  VAL i 485   N  ILE i 455           
SHEET    1  ID14 GLY i 519  ILE i 528  0                                        
SHEET    2  ID14 LYS i 613  PRO i 625 -1  O  ILE i 617   N  VAL i 527           
SHEET    3  ID14 ASN i 540  ILE i 545  0                                        
SHEET    4  ID14 CYS i 548  VAL i 561 -1  O  CYS i 548   N  ILE i 545           
SHEET    5  ID14 LYS i 568  THR i 571  0                                        
SHEET    6  ID14 VAL i 581  THR i 588 -1  O  VAL i 581   N  VAL i 561           
SHEET    7  ID14 ARG i 605  ASP i 610  0                                        
SHEET    8  ID14 GLY i 519  ILE i 528 -1  N  ARG i 520   O  VAL i 624           
SSBOND   1 CYS a   23    CYS a   26                          1555   1555  2.05  
SSBOND   2 CYS b   37    CYS b   40                          1555   1555  2.01  
SSBOND   3 CYS b   56    CYS b   59                          1555   1555  2.04  
SSBOND   4 CYS f  126    CYS f  144                          1555   1555  2.01  
SSBOND   5 CYS i  510    CYS i  516                          1555   1555  2.03  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system