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Database: PDB
Entry: 4N78
LinkDB: 4N78
Original site: 4N78 
HEADER    PROTEIN BINDING                         15-OCT-13   4N78              
TITLE     THE WAVE REGULATORY COMPLEX LINKS DIVERSE RECEPTORS TO THE ACTIN      
TITLE    2 CYTOSKELETON                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CYTOPLASMIC FMR1-INTERACTING PROTEIN 1;                    
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: SPECIFICALLY RAC1-ASSOCIATED PROTEIN 1, SRA-1, P140SRA-1;   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: NCK-ASSOCIATED PROTEIN 1;                                  
COMPND   8 CHAIN: B;                                                            
COMPND   9 SYNONYM: NAP 1, MEMBRANE-ASSOCIATED PROTEIN HEM-2, P125NAP1;         
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 1;          
COMPND  13 CHAIN: D;                                                            
COMPND  14 SYNONYM: WASP FAMILY PROTEIN MEMBER 1, PROTEIN WAVE-1, VERPROLIN     
COMPND  15 HOMOLOGY DOMAIN-CONTAINING PROTEIN 1;                                
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MOL_ID: 4;                                                           
COMPND  18 MOLECULE: PROTEIN BRICK1;                                            
COMPND  19 CHAIN: E;                                                            
COMPND  20 SYNONYM: BRK1;                                                       
COMPND  21 ENGINEERED: YES;                                                     
COMPND  22 MOL_ID: 5;                                                           
COMPND  23 MOLECULE: ABL INTERACTOR 2;                                          
COMPND  24 CHAIN: F;                                                            
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: WIRS;                                                      
COMPND  28 CHAIN: P;                                                            
COMPND  29 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: CYFIP1, KIAA0068;                                              
SOURCE   6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: NCKAP1, HEM2, KIAA0587, NAP1;                                  
SOURCE  13 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: WASF1, KIAA0269, SCAR1, WAVE1;                                 
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: BRK1, C3ORF10, HSPC300, MDS027;                                
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 GENE: ABI2;                                                          
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 SYNTHETIC: YES                                                       
KEYWDS    ACTIN DYNAMICS, PROTEIN BINDING                                       
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Z.C.CHEN                                                              
REVDAT   1   05-FEB-14 4N78    0                                                
JRNL        AUTH   B.CHEN,K.BRINKMANN,Z.CHEN,C.W.PAK,Y.LIAO,S.SHI,L.HENRY,      
JRNL        AUTH 2 N.V.GRISHIN,S.BOGDAN,M.K.ROSEN                               
JRNL        TITL   THE WAVE REGULATORY COMPLEX LINKS DIVERSE RECEPTORS TO THE   
JRNL        TITL 2 ACTIN CYTOSKELETON.                                          
JRNL        REF    CELL(CAMBRIDGE,MASS.)         V. 156   195 2014              
JRNL        REFN                   ISSN 0092-8674                               
JRNL        PMID   24439376                                                     
JRNL        DOI    10.1016/J.CELL.2013.11.048                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.43 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.1_743)                    
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.43                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.98                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 262551                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.189                           
REMARK   3   R VALUE            (WORKING SET) : 0.189                           
REMARK   3   FREE R VALUE                     : 0.209                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 1.340                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3512                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 19.9776 -  7.0059    1.00    10387   139  0.1477 0.1481        
REMARK   3     2  7.0059 -  5.6012    1.00    10430   136  0.2060 0.2050        
REMARK   3     3  5.6012 -  4.9051    1.00    10368   142  0.1623 0.1507        
REMARK   3     4  4.9051 -  4.4621    1.00    10411   143  0.1401 0.1197        
REMARK   3     5  4.4621 -  4.1453    1.00    10439   145  0.1445 0.1875        
REMARK   3     6  4.1453 -  3.9028    1.00    10364   140  0.1548 0.1691        
REMARK   3     7  3.9028 -  3.7087    1.00    10385   137  0.1702 0.2108        
REMARK   3     8  3.7087 -  3.5482    1.00    10449   141  0.1906 0.2249        
REMARK   3     9  3.5482 -  3.4123    1.00    10363   140  0.1994 0.2258        
REMARK   3    10  3.4123 -  3.2951    1.00    10452   141  0.2011 0.2308        
REMARK   3    11  3.2951 -  3.1924    1.00    10341   139  0.2090 0.2215        
REMARK   3    12  3.1924 -  3.1015    1.00    10453   142  0.2120 0.2588        
REMARK   3    13  3.1015 -  3.0202    1.00    10304   141  0.2188 0.2596        
REMARK   3    14  3.0202 -  2.9467    1.00    10401   141  0.2276 0.2828        
REMARK   3    15  2.9467 -  2.8799    1.00    10432   143  0.2201 0.2987        
REMARK   3    16  2.8799 -  2.8188    1.00    10477   143  0.2258 0.2336        
REMARK   3    17  2.8188 -  2.7626    1.00    10381   142  0.2335 0.2517        
REMARK   3    18  2.7626 -  2.7106    1.00    10339   138  0.2453 0.3081        
REMARK   3    19  2.7106 -  2.6623    1.00    10415   141  0.2483 0.2903        
REMARK   3    20  2.6623 -  2.6172    1.00    10441   139  0.2477 0.3002        
REMARK   3    21  2.6172 -  2.5751    1.00    10389   140  0.2595 0.3042        
REMARK   3    22  2.5751 -  2.5356    1.00    10414   143  0.2632 0.3000        
REMARK   3    23  2.5356 -  2.4984    0.99    10245   141  0.2752 0.2918        
REMARK   3    24  2.4984 -  2.4632    0.98    10217   140  0.2863 0.2942        
REMARK   3    25  2.4632 -  2.4300    0.94     9742   135  0.3096 0.3782        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.20                                          
REMARK   3   SHRINKAGE RADIUS   : 0.95                                          
REMARK   3   K_SOL              : 0.32                                          
REMARK   3   B_SOL              : 45.53                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.690            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.000           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 16.71480                                             
REMARK   3    B22 (A**2) : 0.09430                                              
REMARK   3    B33 (A**2) : -16.80910                                            
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : -0.00000                                             
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.002          22517                                  
REMARK   3   ANGLE     :  0.463          30397                                  
REMARK   3   CHIRALITY :  0.036           3417                                  
REMARK   3   PLANARITY :  0.002           3871                                  
REMARK   3   DIHEDRAL  : 10.982           8527                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 71                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 5:68)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  45.6439  56.0738 253.0081              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5168 T22:   0.5045                                     
REMARK   3      T33:   0.3945 T12:  -0.0306                                     
REMARK   3      T13:  -0.0557 T23:   0.0465                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0413 L22:  -0.0379                                     
REMARK   3      L33:  -0.0313 L12:   0.1251                                     
REMARK   3      L13:  -0.0102 L23:  -0.0372                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0395 S12:  -0.2202 S13:   0.4331                       
REMARK   3      S21:  -0.0495 S22:   0.0103 S23:   0.4159                       
REMARK   3      S31:   0.0757 S32:   0.2028 S33:   0.0000                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 69:144)                             
REMARK   3    ORIGIN FOR THE GROUP (A):   0.7783  45.4532 240.8070              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2271 T22:   0.3282                                     
REMARK   3      T33:   0.1868 T12:   0.0517                                     
REMARK   3      T13:   0.0841 T23:   0.0536                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3302 L22:  -0.3489                                     
REMARK   3      L33:   0.3078 L12:   0.4390                                     
REMARK   3      L13:  -0.4879 L23:   0.3456                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1634 S12:   0.1129 S13:  -0.0952                       
REMARK   3      S21:   0.4418 S22:   0.1629 S23:  -0.1046                       
REMARK   3      S31:   0.1269 S32:  -0.1464 S33:  -0.0000                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 145:185)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  17.6776  52.9928 243.9399              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3293 T22:   0.2714                                     
REMARK   3      T33:   0.2825 T12:   0.0809                                     
REMARK   3      T13:  -0.0447 T23:   0.0188                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1153 L22:   0.1932                                     
REMARK   3      L33:   0.2777 L12:   0.0127                                     
REMARK   3      L13:  -0.2824 L23:   0.1666                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3575 S12:  -0.1437 S13:   0.1652                       
REMARK   3      S21:   0.0917 S22:   0.1312 S23:  -0.0380                       
REMARK   3      S31:  -0.1285 S32:  -0.0757 S33:  -0.0000                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 186:223)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.6862  51.7564 244.0854              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4160 T22:   0.4763                                     
REMARK   3      T33:   0.4068 T12:   0.1730                                     
REMARK   3      T13:   0.0485 T23:  -0.0229                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0462 L22:   0.0162                                     
REMARK   3      L33:   0.1144 L12:  -0.0492                                     
REMARK   3      L13:   0.0318 L23:   0.0476                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1523 S12:  -0.0036 S13:   0.3868                       
REMARK   3      S21:   0.2502 S22:   0.0657 S23:   0.1832                       
REMARK   3      S31:  -0.3050 S32:  -0.1632 S33:   0.0000                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 224:334)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  25.7014  61.1756 236.3616              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3782 T22:   0.2318                                     
REMARK   3      T33:   0.2965 T12:   0.0205                                     
REMARK   3      T13:  -0.1195 T23:  -0.0128                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2101 L22:   0.0998                                     
REMARK   3      L33:   0.2333 L12:  -0.1438                                     
REMARK   3      L13:   0.0649 L23:  -0.1430                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2371 S12:  -0.0236 S13:  -0.0249                       
REMARK   3      S21:   0.0177 S22:   0.1328 S23:   0.0169                       
REMARK   3      S31:  -0.1515 S32:   0.0521 S33:  -0.0000                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 335:350)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  30.6915  54.8363 214.6862              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7056 T22:   0.4887                                     
REMARK   3      T33:   0.2554 T12:   0.0853                                     
REMARK   3      T13:  -0.0250 T23:   0.1034                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0071 L22:   0.0044                                     
REMARK   3      L33:  -0.0368 L12:  -0.0050                                     
REMARK   3      L13:  -0.0463 L23:  -0.0081                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0130 S12:   0.2424 S13:  -0.2252                       
REMARK   3      S21:   0.0501 S22:   0.4042 S23:  -0.0880                       
REMARK   3      S31:  -0.3414 S32:  -0.2295 S33:  -0.0000                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 351:382)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  45.2006  33.0612 221.7771              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1193 T22:   0.2885                                     
REMARK   3      T33:   0.2570 T12:   0.1086                                     
REMARK   3      T13:  -0.1084 T23:  -0.1173                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1078 L22:  -0.0400                                     
REMARK   3      L33:   0.0248 L12:  -0.0923                                     
REMARK   3      L13:   0.0233 L23:  -0.0141                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3188 S12:   0.0016 S13:  -0.2104                       
REMARK   3      S21:   0.2020 S22:   0.3258 S23:   0.2454                       
REMARK   3      S31:   0.0183 S32:   0.5409 S33:  -0.0000                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 383:439)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  27.0806  45.4627 220.0639              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2908 T22:   0.2034                                     
REMARK   3      T33:   0.3087 T12:   0.0027                                     
REMARK   3      T13:  -0.0394 T23:   0.0136                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0451 L22:  -0.0615                                     
REMARK   3      L33:   0.4888 L12:  -0.2661                                     
REMARK   3      L13:  -0.5167 L23:   0.0575                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0483 S12:   0.0875 S13:   0.0955                       
REMARK   3      S21:   0.0327 S22:   0.0116 S23:  -0.1032                       
REMARK   3      S31:  -0.1007 S32:  -0.0248 S33:   0.0000                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 440:521)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  41.3629  38.1077 240.0520              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2876 T22:   0.2579                                     
REMARK   3      T33:   0.2810 T12:   0.0187                                     
REMARK   3      T13:  -0.0978 T23:  -0.0100                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0455 L22:   0.3939                                     
REMARK   3      L33:   0.1830 L12:  -0.0233                                     
REMARK   3      L13:  -0.0762 L23:  -0.1613                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0277 S12:   0.0143 S13:  -0.0398                       
REMARK   3      S21:   0.1014 S22:   0.0133 S23:  -0.1159                       
REMARK   3      S31:   0.0284 S32:  -0.0313 S33:  -0.0000                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 522:546)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  58.8889  34.4288 261.2691              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9384 T22:   1.0946                                     
REMARK   3      T33:   0.9788 T12:   0.0394                                     
REMARK   3      T13:  -0.5919 T23:  -0.0451                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0223 L22:   0.0253                                     
REMARK   3      L33:   0.0121 L12:   0.0057                                     
REMARK   3      L13:   0.0166 L23:  -0.0084                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5792 S12:  -0.2552 S13:   0.0331                       
REMARK   3      S21:   0.1358 S22:  -0.4187 S23:  -0.2501                       
REMARK   3      S31:   0.2700 S32:  -0.0339 S33:  -0.0000                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 547:617)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  41.4109  41.7060 246.2280              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4295 T22:   0.3066                                     
REMARK   3      T33:   0.3699 T12:   0.0122                                     
REMARK   3      T13:  -0.0767 T23:   0.0254                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1726 L22:   0.2801                                     
REMARK   3      L33:   0.3271 L12:  -0.0061                                     
REMARK   3      L13:   0.0238 L23:  -0.1413                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1135 S12:   0.1643 S13:   0.0669                       
REMARK   3      S21:   0.1246 S22:  -0.0993 S23:  -0.0820                       
REMARK   3      S31:   0.0005 S32:  -0.0244 S33:   0.0000                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 618:738)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  17.9599  33.6725 208.2219              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2074 T22:   0.2445                                     
REMARK   3      T33:   0.2412 T12:  -0.0206                                     
REMARK   3      T13:  -0.0174 T23:  -0.0200                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0876 L22:   0.3964                                     
REMARK   3      L33:   0.1482 L12:  -0.2481                                     
REMARK   3      L13:  -0.2348 L23:   0.2242                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0004 S12:   0.0631 S13:  -0.0205                       
REMARK   3      S21:   0.0492 S22:  -0.0100 S23:  -0.0297                       
REMARK   3      S31:  -0.0256 S32:  -0.0593 S33:  -0.0000                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 739:806)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  19.9893  18.5458 193.5673              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2496 T22:   0.2821                                     
REMARK   3      T33:   0.3098 T12:  -0.0348                                     
REMARK   3      T13:  -0.0006 T23:  -0.0289                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.1460 L22:   0.3340                                     
REMARK   3      L33:   0.1107 L12:  -0.0895                                     
REMARK   3      L13:   0.0527 L23:   0.3462                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0208 S12:   0.0520 S13:  -0.0540                       
REMARK   3      S21:   0.0179 S22:  -0.0850 S23:  -0.0529                       
REMARK   3      S31:  -0.0836 S32:   0.0078 S33:  -0.0000                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 807:873)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  15.4637   9.8279 173.4137              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2479 T22:   0.2478                                     
REMARK   3      T33:   0.2444 T12:   0.0079                                     
REMARK   3      T13:   0.0035 T23:  -0.0521                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0305 L22:   0.1646                                     
REMARK   3      L33:   0.3235 L12:   0.2144                                     
REMARK   3      L13:  -0.0303 L23:   0.3641                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0810 S12:   0.0081 S13:  -0.0087                       
REMARK   3      S21:   0.0284 S22:  -0.1383 S23:  -0.0426                       
REMARK   3      S31:   0.1173 S32:  -0.1457 S33:  -0.0000                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 874:920)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  17.6013  19.1466 173.7394              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3739 T22:   0.3337                                     
REMARK   3      T33:   0.3749 T12:  -0.0255                                     
REMARK   3      T13:  -0.0005 T23:  -0.0454                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1452 L22:   0.0528                                     
REMARK   3      L33:   0.1180 L12:   0.0172                                     
REMARK   3      L13:   0.1948 L23:   0.2160                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0622 S12:  -0.0005 S13:  -0.0175                       
REMARK   3      S21:  -0.0233 S22:  -0.1999 S23:  -0.0049                       
REMARK   3      S31:  -0.0606 S32:  -0.1049 S33:  -0.0000                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 921:998)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   5.7695   1.0402 142.4106              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1938 T22:   0.3975                                     
REMARK   3      T33:   0.2582 T12:   0.0598                                     
REMARK   3      T13:  -0.0231 T23:  -0.0853                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2485 L22:   0.8353                                     
REMARK   3      L33:   0.0795 L12:  -0.2142                                     
REMARK   3      L13:  -0.1218 L23:   0.1625                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0293 S12:  -0.0219 S13:   0.0171                       
REMARK   3      S21:  -0.1035 S22:  -0.2400 S23:   0.1327                       
REMARK   3      S31:  -0.1196 S32:  -0.3947 S33:  -0.0000                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 999:1036)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  31.3509  -2.1738 168.0379              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2919 T22:   0.3026                                     
REMARK   3      T33:   0.3305 T12:   0.0309                                     
REMARK   3      T13:   0.0323 T23:  -0.0365                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0428 L22:  -0.0083                                     
REMARK   3      L33:   0.0762 L12:   0.0377                                     
REMARK   3      L13:  -0.0997 L23:  -0.2718                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1098 S12:  -0.0235 S13:  -0.0107                       
REMARK   3      S21:  -0.0812 S22:   0.0346 S23:  -0.0942                       
REMARK   3      S31:   0.1323 S32:  -0.0628 S33:  -0.0000                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 1037:1098)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  39.6947 -11.6657 178.2632              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4525 T22:   0.2514                                     
REMARK   3      T33:   0.3792 T12:   0.1324                                     
REMARK   3      T13:   0.0098 T23:   0.0588                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0554 L22:   0.2661                                     
REMARK   3      L33:  -0.0392 L12:  -0.0053                                     
REMARK   3      L13:  -0.0139 L23:  -0.1386                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0493 S12:   0.0039 S13:   0.0993                       
REMARK   3      S21:   0.0222 S22:  -0.1602 S23:  -0.1510                       
REMARK   3      S31:   0.6557 S32:  -0.1755 S33:   0.0000                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 1099:1227)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  14.0534   0.5154 138.2062              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2710 T22:   0.3142                                     
REMARK   3      T33:   0.2963 T12:   0.0481                                     
REMARK   3      T13:   0.0078 T23:  -0.0319                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1481 L22:   0.3714                                     
REMARK   3      L33:   0.4666 L12:   0.1135                                     
REMARK   3      L13:  -0.2891 L23:   0.5533                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0053 S12:   0.0161 S13:  -0.0207                       
REMARK   3      S21:  -0.0526 S22:  -0.0733 S23:  -0.0388                       
REMARK   3      S31:  -0.0578 S32:  -0.1578 S33:   0.0000                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 1237:1250)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  14.8608 -32.1373 129.4916              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7263 T22:   0.6611                                     
REMARK   3      T33:   0.4572 T12:  -0.2197                                     
REMARK   3      T13:   0.0916 T23:  -0.1289                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0012 L22:   0.0135                                     
REMARK   3      L33:   0.0019 L12:  -0.0261                                     
REMARK   3      L13:   0.0276 L23:  -0.0050                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0745 S12:   0.0636 S13:  -0.1848                       
REMARK   3      S21:   0.1067 S22:   0.2374 S23:   0.1742                       
REMARK   3      S31:  -0.0754 S32:  -0.1150 S33:   0.0000                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 7:66)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  65.7965 -22.2384 114.7955              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2878 T22:   0.3199                                     
REMARK   3      T33:   0.3776 T12:   0.0694                                     
REMARK   3      T13:   0.1032 T23:  -0.0525                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1015 L22:   0.0600                                     
REMARK   3      L33:   0.0459 L12:  -0.1130                                     
REMARK   3      L13:   0.0739 L23:  -0.0139                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0137 S12:   0.0330 S13:  -0.0590                       
REMARK   3      S21:   0.0364 S22:   0.0282 S23:  -0.0996                       
REMARK   3      S31:   0.1636 S32:   0.1407 S33:   0.0000                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 67:143)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  59.2076 -28.0335 110.6435              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2607 T22:   0.2951                                     
REMARK   3      T33:   0.2944 T12:   0.0884                                     
REMARK   3      T13:   0.1149 T23:  -0.0562                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1638 L22:  -0.4054                                     
REMARK   3      L33:   0.1194 L12:  -0.2200                                     
REMARK   3      L13:  -0.1334 L23:   0.5498                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1990 S12:  -0.0782 S13:   0.0110                       
REMARK   3      S21:  -0.1079 S22:   0.1803 S23:   0.0980                       
REMARK   3      S31:   0.2772 S32:   0.0479 S33:   0.0000                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 144:186)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  72.9806 -23.7659 110.0139              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2757 T22:   0.4803                                     
REMARK   3      T33:   0.3453 T12:   0.0707                                     
REMARK   3      T13:   0.0926 T23:  -0.0971                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1241 L22:   0.0872                                     
REMARK   3      L33:   0.0544 L12:   0.1463                                     
REMARK   3      L13:   0.0003 L23:  -0.1100                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1134 S12:   0.4393 S13:  -0.0251                       
REMARK   3      S21:  -0.0610 S22:   0.1649 S23:  -0.0138                       
REMARK   3      S31:  -0.0622 S32:   0.3727 S33:  -0.0000                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 187:314)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  39.6673 -16.0845 106.0872              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3194 T22:   0.2974                                     
REMARK   3      T33:   0.2643 T12:  -0.0077                                     
REMARK   3      T13:   0.0583 T23:   0.0053                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2618 L22:   0.2112                                     
REMARK   3      L33:   0.3994 L12:  -0.2729                                     
REMARK   3      L13:  -0.2675 L23:   0.3911                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0272 S12:   0.0774 S13:   0.0302                       
REMARK   3      S21:  -0.0732 S22:  -0.0219 S23:  -0.0122                       
REMARK   3      S31:  -0.0643 S32:  -0.1035 S33:   0.0000                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 315:368)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  34.1961  -7.9841 113.3587              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2673 T22:   0.2638                                     
REMARK   3      T33:   0.3160 T12:  -0.0219                                     
REMARK   3      T13:   0.0341 T23:   0.0002                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3014 L22:   0.1111                                     
REMARK   3      L33:  -0.0138 L12:  -0.0246                                     
REMARK   3      L13:  -0.0682 L23:   0.0309                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0629 S12:   0.1344 S13:   0.0962                       
REMARK   3      S21:  -0.0617 S22:  -0.0004 S23:   0.0444                       
REMARK   3      S31:  -0.0703 S32:  -0.2310 S33:   0.0000                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 369:534)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  32.2205 -28.7004 120.0970              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2717 T22:   0.2274                                     
REMARK   3      T33:   0.2523 T12:   0.0033                                     
REMARK   3      T13:   0.0515 T23:  -0.0196                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2439 L22:   0.5433                                     
REMARK   3      L33:   0.5695 L12:   0.2778                                     
REMARK   3      L13:  -0.2376 L23:   0.0791                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0523 S12:   0.0092 S13:   0.0122                       
REMARK   3      S21:   0.0412 S22:   0.0006 S23:  -0.0350                       
REMARK   3      S31:   0.1112 S32:  -0.0687 S33:   0.0000                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 535:624)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  45.8007  -6.9472 136.5488              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2879 T22:   0.2933                                     
REMARK   3      T33:   0.3303 T12:   0.0136                                     
REMARK   3      T13:   0.0292 T23:  -0.0362                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0309 L22:  -0.0867                                     
REMARK   3      L33:   0.4024 L12:  -0.1440                                     
REMARK   3      L13:  -0.2545 L23:  -0.0082                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0049 S12:  -0.0847 S13:   0.0135                       
REMARK   3      S21:  -0.0892 S22:   0.0198 S23:  -0.0034                       
REMARK   3      S31:  -0.0114 S32:   0.1155 S33:   0.0000                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 625:660)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  27.7099  28.9381 166.6542              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4032 T22:   0.2809                                     
REMARK   3      T33:   0.2028 T12:   0.0313                                     
REMARK   3      T13:   0.0420 T23:  -0.0283                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0001 L22:   0.0452                                     
REMARK   3      L33:   0.0459 L12:   0.0080                                     
REMARK   3      L13:   0.0518 L23:  -0.0678                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0364 S12:  -0.0126 S13:  -0.2011                       
REMARK   3      S21:  -0.4332 S22:   0.1770 S23:  -0.2036                       
REMARK   3      S31:  -0.5536 S32:  -0.0195 S33:  -0.0000                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 661:768)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  38.4109   3.0386 154.8491              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3024 T22:   0.3204                                     
REMARK   3      T33:   0.3080 T12:   0.0150                                     
REMARK   3      T13:   0.0197 T23:  -0.0289                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.3103 L22:  -0.1461                                     
REMARK   3      L33:   0.5536 L12:  -0.0090                                     
REMARK   3      L13:  -0.1007 L23:   0.0285                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0077 S12:  -0.0274 S13:   0.0032                       
REMARK   3      S21:  -0.0456 S22:   0.0292 S23:   0.0193                       
REMARK   3      S31:  -0.0162 S32:   0.0501 S33:   0.0000                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 769:850)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  48.1064  15.8494 178.4307              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0758 T22:   0.1580                                     
REMARK   3      T33:   0.1545 T12:  -0.0211                                     
REMARK   3      T13:   0.0253 T23:  -0.0372                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1038 L22:   0.2102                                     
REMARK   3      L33:   0.4657 L12:   0.0633                                     
REMARK   3      L13:   0.1260 L23:  -0.0351                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0226 S12:   0.0683 S13:  -0.0793                       
REMARK   3      S21:   0.0354 S22:  -0.0110 S23:   0.1216                       
REMARK   3      S31:  -0.0830 S32:   0.2329 S33:   0.0000                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 851:917)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  61.2075  18.0791 202.5550              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1714 T22:   0.3924                                     
REMARK   3      T33:   0.3346 T12:   0.0440                                     
REMARK   3      T13:  -0.0723 T23:  -0.0235                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1218 L22:   0.4188                                     
REMARK   3      L33:   0.1545 L12:  -0.2235                                     
REMARK   3      L13:  -0.0833 L23:  -0.0185                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0818 S12:  -0.0245 S13:  -0.0026                       
REMARK   3      S21:  -0.0299 S22:   0.0638 S23:  -0.2105                       
REMARK   3      S31:   0.0972 S32:   0.1719 S33:  -0.0000                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 918:968)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  39.0573  -0.3301 191.1585              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3029 T22:   0.2174                                     
REMARK   3      T33:   0.2429 T12:  -0.0060                                     
REMARK   3      T13:  -0.0257 T23:   0.0102                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1594 L22:   0.1953                                     
REMARK   3      L33:   0.0434 L12:   0.0063                                     
REMARK   3      L13:  -0.0138 L23:   0.0390                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0250 S12:  -0.0942 S13:   0.0577                       
REMARK   3      S21:   0.1910 S22:  -0.0259 S23:  -0.0017                       
REMARK   3      S31:   0.0929 S32:   0.0167 S33:  -0.0000                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 969:1017)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  57.2783  14.3773 202.6841              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3877 T22:   0.4600                                     
REMARK   3      T33:   0.4161 T12:   0.0065                                     
REMARK   3      T13:  -0.0929 T23:  -0.0003                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2274 L22:   0.0719                                     
REMARK   3      L33:   0.2074 L12:   0.0404                                     
REMARK   3      L13:  -0.1381 L23:  -0.0240                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0215 S12:  -0.0515 S13:   0.0614                       
REMARK   3      S21:  -0.0022 S22:   0.0131 S23:  -0.0224                       
REMARK   3      S31:   0.1431 S32:   0.1452 S33:   0.0000                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 1018:1121)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  46.7488  22.6878 206.5823              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3002 T22:   0.3057                                     
REMARK   3      T33:   0.3110 T12:  -0.0113                                     
REMARK   3      T13:  -0.0124 T23:  -0.0273                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3372 L22:   0.0543                                     
REMARK   3      L33:   0.4910 L12:  -0.2678                                     
REMARK   3      L13:  -0.0750 L23:   0.4549                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0576 S12:  -0.0597 S13:  -0.0133                       
REMARK   3      S21:   0.0936 S22:   0.0734 S23:   0.0804                       
REMARK   3      S31:  -0.0439 S32:   0.1606 S33:   0.0000                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 15:22)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  32.4004  31.7312 261.2885              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5279 T22:   1.4006                                     
REMARK   3      T33:   1.2425 T12:   0.0108                                     
REMARK   3      T13:  -0.4135 T23:  -0.0229                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0012 L22:   0.0009                                     
REMARK   3      L33:  -0.0010 L12:   0.0173                                     
REMARK   3      L13:   0.0078 L23:  -0.0073                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0894 S12:  -0.0010 S13:  -0.0820                       
REMARK   3      S21:  -0.0679 S22:  -0.0895 S23:   0.0027                       
REMARK   3      S31:   0.0169 S32:  -0.0468 S33:  -0.0000                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 23:33)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  31.4298  20.8986 260.9308              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9040 T22:   0.6742                                     
REMARK   3      T33:   0.5352 T12:  -0.0036                                     
REMARK   3      T13:  -0.0855 T23:  -0.0970                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0027 L22:   0.0044                                     
REMARK   3      L33:   0.0069 L12:   0.0103                                     
REMARK   3      L13:  -0.0048 L23:  -0.0040                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1636 S12:  -0.0269 S13:   0.1993                       
REMARK   3      S21:   0.1968 S22:   0.0305 S23:  -0.0738                       
REMARK   3      S31:  -0.0318 S32:  -0.1273 S33:   0.0000                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 34:49)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  24.0999  13.2068 242.6941              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3916 T22:   0.7903                                     
REMARK   3      T33:  -0.4182 T12:  -0.1567                                     
REMARK   3      T13:  -0.1329 T23:  -1.0314                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0169 L22:   0.0027                                     
REMARK   3      L33:   0.0098 L12:  -0.0257                                     
REMARK   3      L13:   0.0112 L23:  -0.0294                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4185 S12:  -0.0964 S13:   0.0125                       
REMARK   3      S21:   0.0122 S22:  -0.2065 S23:  -0.4999                       
REMARK   3      S31:  -0.2209 S32:  -0.3538 S33:   0.0000                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 50:62)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  18.4652   5.1838 223.3337              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5497 T22:   0.9703                                     
REMARK   3      T33:   0.7229 T12:  -0.2798                                     
REMARK   3      T13:   0.0514 T23:  -0.2599                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0023 L22:   0.0062                                     
REMARK   3      L33:   0.0186 L12:   0.0324                                     
REMARK   3      L13:   0.0109 L23:  -0.0307                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1826 S12:  -0.2022 S13:   0.3764                       
REMARK   3      S21:  -0.2024 S22:   0.2282 S23:   0.2270                       
REMARK   3      S31:   0.0469 S32:  -0.3920 S33:  -0.0000                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 63:73)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  15.3301  -5.5601 209.2524              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6514 T22:   0.3940                                     
REMARK   3      T33:   0.4052 T12:  -0.2132                                     
REMARK   3      T13:   0.0359 T23:  -0.0164                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0088 L22:   0.0165                                     
REMARK   3      L33:   0.0078 L12:  -0.0028                                     
REMARK   3      L13:  -0.0148 L23:   0.0009                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1728 S12:  -0.3116 S13:   0.2665                       
REMARK   3      S21:  -0.0102 S22:  -0.1655 S23:   0.2536                       
REMARK   3      S31:   0.0652 S32:  -0.1376 S33:  -0.0000                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 74:87)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  15.0091 -15.6498 192.0057              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7609 T22:   0.4926                                     
REMARK   3      T33:   0.3764 T12:  -0.2031                                     
REMARK   3      T13:   0.0377 T23:  -0.0533                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0187 L22:  -0.0047                                     
REMARK   3      L33:   0.0050 L12:  -0.0078                                     
REMARK   3      L13:   0.0024 L23:  -0.0048                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2597 S12:  -0.2252 S13:  -0.1322                       
REMARK   3      S21:  -0.1758 S22:   0.0366 S23:   0.0192                       
REMARK   3      S31:   0.1328 S32:  -0.1217 S33:  -0.0000                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 88:98)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   3.3409  -5.6222 181.1846              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2743 T22:   0.9455                                     
REMARK   3      T33:   1.5107 T12:   0.0215                                     
REMARK   3      T13:  -0.0601 T23:   0.1137                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0009 L22:  -0.0014                                     
REMARK   3      L33:  -0.0151 L12:  -0.0022                                     
REMARK   3      L13:   0.0019 L23:   0.0031                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0765 S12:   0.0413 S13:  -0.0006                       
REMARK   3      S21:  -0.0641 S22:  -0.1033 S23:   0.0889                       
REMARK   3      S31:  -0.0676 S32:  -0.1547 S33:  -0.0000                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 99:106)                             
REMARK   3    ORIGIN FOR THE GROUP (A):   7.3878   6.4336 194.7578              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4879 T22:   0.5219                                     
REMARK   3      T33:   0.3916 T12:  -0.0478                                     
REMARK   3      T13:   0.0484 T23:  -0.0667                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0127 L22:   0.0169                                     
REMARK   3      L33:   0.0032 L12:   0.0061                                     
REMARK   3      L13:  -0.0102 L23:  -0.0070                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2151 S12:  -0.1089 S13:  -0.1563                       
REMARK   3      S21:   0.0003 S22:  -0.0243 S23:   0.2773                       
REMARK   3      S31:  -0.1574 S32:  -0.0720 S33:  -0.0000                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 107:111)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.1192  18.9565 208.6816              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4719 T22:   0.6580                                     
REMARK   3      T33:   0.4881 T12:  -0.0158                                     
REMARK   3      T13:  -0.0561 T23:  -0.1673                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0067 L22:  -0.0050                                     
REMARK   3      L33:   0.0081 L12:   0.0057                                     
REMARK   3      L13:   0.0115 L23:   0.0074                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0194 S12:   0.2002 S13:   0.0028                       
REMARK   3      S21:  -0.0362 S22:   0.0823 S23:   0.2162                       
REMARK   3      S31:   0.0037 S32:  -0.1862 S33:  -0.0000                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 112:125)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.2037  20.5981 225.5763              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5952 T22:   0.3680                                     
REMARK   3      T33:   0.3832 T12:  -0.0310                                     
REMARK   3      T13:   0.0619 T23:   0.0630                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0102 L22:   0.0152                                     
REMARK   3      L33:   0.0167 L12:   0.0046                                     
REMARK   3      L13:   0.0112 L23:   0.0321                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4324 S12:   0.1336 S13:  -0.4333                       
REMARK   3      S21:   0.2673 S22:   0.1198 S23:  -0.0661                       
REMARK   3      S31:   0.1501 S32:   0.0042 S33:  -0.0000                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 126:132)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   3.1210  29.4456 233.9794              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6883 T22:   0.5775                                     
REMARK   3      T33:   0.4848 T12:  -0.0080                                     
REMARK   3      T13:   0.1675 T23:  -0.0457                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0058 L22:   0.0050                                     
REMARK   3      L33:   0.0117 L12:  -0.0025                                     
REMARK   3      L13:  -0.0113 L23:  -0.0037                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1221 S12:  -0.1197 S13:   0.1610                       
REMARK   3      S21:   0.0426 S22:  -0.0236 S23:   0.1900                       
REMARK   3      S31:  -0.0140 S32:  -0.0109 S33:  -0.0000                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 133:144)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -14.1562  34.8568 226.4794              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4483 T22:   0.7142                                     
REMARK   3      T33:   0.6185 T12:  -0.1454                                     
REMARK   3      T13:   0.1274 T23:  -0.0223                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0049 L22:   0.0063                                     
REMARK   3      L33:   0.0010 L12:   0.0185                                     
REMARK   3      L13:  -0.0007 L23:   0.0033                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2201 S12:   0.0915 S13:  -0.1322                       
REMARK   3      S21:  -0.1153 S22:  -0.1295 S23:   0.0198                       
REMARK   3      S31:   0.0327 S32:  -0.0949 S33:  -0.0000                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 145:162)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.6566  34.7185 216.6440              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4013 T22:   0.5734                                     
REMARK   3      T33:   0.4607 T12:   0.0420                                     
REMARK   3      T13:  -0.0331 T23:  -0.0310                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0258 L22:  -0.0277                                     
REMARK   3      L33:   0.0083 L12:  -0.0459                                     
REMARK   3      L13:  -0.0041 L23:  -0.0217                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0570 S12:   0.1350 S13:  -0.1401                       
REMARK   3      S21:  -0.0371 S22:  -0.1514 S23:   0.2391                       
REMARK   3      S31:   0.0643 S32:  -0.1858 S33:   0.0000                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 163:169)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.6336  37.9569 200.3934              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7066 T22:   1.0633                                     
REMARK   3      T33:   0.4749 T12:   0.3076                                     
REMARK   3      T13:   0.0435 T23:   0.1623                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0019 L22:   0.0083                                     
REMARK   3      L33:   0.0076 L12:   0.0080                                     
REMARK   3      L13:  -0.0033 L23:  -0.0030                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0873 S12:   0.0453 S13:   0.0688                       
REMARK   3      S21:   0.0692 S22:  -0.0159 S23:   0.1351                       
REMARK   3      S31:  -0.1116 S32:   0.0854 S33:  -0.0000                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 170:176)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.6317  41.2314 190.2299              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2901 T22:   1.6534                                     
REMARK   3      T33:   1.2574 T12:   0.1840                                     
REMARK   3      T13:   0.0349 T23:   0.0764                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0046 L22:   0.0021                                     
REMARK   3      L33:  -0.0008 L12:  -0.0004                                     
REMARK   3      L13:   0.0003 L23:  -0.0047                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0078 S12:  -0.0082 S13:   0.0272                       
REMARK   3      S21:   0.0623 S22:   0.0122 S23:   0.0361                       
REMARK   3      S31:   0.0099 S32:   0.0663 S33:   0.0000                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 177:501)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.5099   7.4340 168.7486              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8672 T22:   0.7807                                     
REMARK   3      T33:   0.7961 T12:   0.2069                                     
REMARK   3      T13:  -0.1810 T23:  -0.1896                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1069 L22:  -0.0193                                     
REMARK   3      L33:  -0.0843 L12:  -0.0631                                     
REMARK   3      L13:   0.1259 L23:   0.0655                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3740 S12:  -0.0710 S13:   0.3552                       
REMARK   3      S21:  -0.1572 S22:   0.0327 S23:  -0.0159                       
REMARK   3      S31:   0.4651 S32:  -0.2697 S33:   0.0000                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 502:511)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.6279   5.5375 174.7661              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0089 T22:   1.3403                                     
REMARK   3      T33:   0.8483 T12:  -0.0682                                     
REMARK   3      T13:   0.0936 T23:   0.0597                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0017 L22:   0.0002                                     
REMARK   3      L33:   0.0013 L12:  -0.0034                                     
REMARK   3      L13:  -0.0046 L23:  -0.0047                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0570 S12:  -0.0625 S13:   0.0999                       
REMARK   3      S21:  -0.0097 S22:   0.0268 S23:   0.1706                       
REMARK   3      S31:  -0.0126 S32:  -0.0746 S33:   0.0000                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 512:516)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.3983  12.8891 183.3288              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5823 T22:   1.8923                                     
REMARK   3      T33:   1.4302 T12:  -0.3110                                     
REMARK   3      T13:   0.0305 T23:   0.2736                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0000 L22:   0.0062                                     
REMARK   3      L33:   0.0013 L12:  -0.0006                                     
REMARK   3      L13:   0.0009 L23:  -0.0048                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0412 S12:  -0.0213 S13:  -0.1356                       
REMARK   3      S21:   0.0934 S22:   0.0404 S23:  -0.0547                       
REMARK   3      S31:   0.0297 S32:  -0.0240 S33:  -0.0001                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 527:532)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.6742  24.5053 203.2764              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3834 T22:   0.6051                                     
REMARK   3      T33:   0.5621 T12:   0.0533                                     
REMARK   3      T13:   0.0319 T23:   0.0045                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0064 L22:   0.0021                                     
REMARK   3      L33:   0.0006 L12:   0.0027                                     
REMARK   3      L13:  -0.0043 L23:   0.0043                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0150 S12:  -0.0125 S13:   0.0113                       
REMARK   3      S21:  -0.0211 S22:   0.0380 S23:  -0.0444                       
REMARK   3      S31:   0.0181 S32:   0.0064 S33:   0.0000                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 533:543)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   6.8266  31.0013 194.3738              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3912 T22:   0.6022                                     
REMARK   3      T33:   0.4630 T12:   0.1969                                     
REMARK   3      T13:  -0.0341 T23:   0.0148                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0110 L22:   0.0027                                     
REMARK   3      L33:   0.0061 L12:  -0.0045                                     
REMARK   3      L13:  -0.0023 L23:   0.0084                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1542 S12:  -0.0272 S13:   0.3071                       
REMARK   3      S21:  -0.0720 S22:  -0.1984 S23:   0.0689                       
REMARK   3      S31:   0.1474 S32:  -0.2351 S33:  -0.0000                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 6:13)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  43.4546  26.7947 263.3893              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8327 T22:   0.6603                                     
REMARK   3      T33:   0.6084 T12:   0.1737                                     
REMARK   3      T13:  -0.3483 T23:  -0.0902                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0082 L22:  -0.0011                                     
REMARK   3      L33:  -0.0005 L12:  -0.0024                                     
REMARK   3      L13:  -0.0007 L23:   0.0025                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0052 S12:  -0.0579 S13:   0.0564                       
REMARK   3      S21:   0.0764 S22:   0.0304 S23:  -0.0730                       
REMARK   3      S31:   0.0158 S32:   0.0401 S33:  -0.0000                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 14:29)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  38.0406  20.6485 248.8674              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4650 T22:   0.3679                                     
REMARK   3      T33:   0.4253 T12:  -0.0218                                     
REMARK   3      T13:  -0.0396 T23:  -0.0474                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0198 L22:   0.0242                                     
REMARK   3      L33:  -0.0099 L12:  -0.0129                                     
REMARK   3      L13:  -0.0001 L23:   0.0336                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0001 S12:   0.1024 S13:  -0.0851                       
REMARK   3      S21:   0.3406 S22:  -0.0830 S23:  -0.0901                       
REMARK   3      S31:  -0.0166 S32:  -0.1095 S33:  -0.0000                       
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 30:46)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  29.0052  12.9773 226.1720              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6125 T22:   0.4027                                     
REMARK   3      T33:   0.4690 T12:   0.0896                                     
REMARK   3      T13:  -0.1280 T23:  -0.0630                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0172 L22:  -0.0011                                     
REMARK   3      L33:   0.0281 L12:   0.0258                                     
REMARK   3      L13:  -0.0264 L23:  -0.0276                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3622 S12:  -0.1574 S13:  -0.0622                       
REMARK   3      S21:  -0.1327 S22:  -0.2236 S23:   0.2525                       
REMARK   3      S31:  -0.1368 S32:  -0.0923 S33:  -0.0000                       
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 47:58)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  21.0152   4.7932 207.8812              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3403 T22:   0.3371                                     
REMARK   3      T33:   0.3246 T12:  -0.0811                                     
REMARK   3      T13:  -0.0399 T23:  -0.0208                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0004 L22:  -0.0051                                     
REMARK   3      L33:   0.0040 L12:  -0.0004                                     
REMARK   3      L13:   0.0128 L23:   0.0089                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3234 S12:  -0.1463 S13:   0.0074                       
REMARK   3      S21:  -0.0690 S22:  -0.0143 S23:   0.1387                       
REMARK   3      S31:   0.0064 S32:  -0.0678 S33:   0.0000                       
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 59:72)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  11.8047  -2.7767 194.2186              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4640 T22:   0.3506                                     
REMARK   3      T33:   0.4325 T12:  -0.0969                                     
REMARK   3      T13:   0.0227 T23:  -0.0825                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0012 L22:   0.0293                                     
REMARK   3      L33:  -0.0186 L12:  -0.0030                                     
REMARK   3      L13:   0.0018 L23:  -0.0067                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2319 S12:  -0.1847 S13:  -0.2704                       
REMARK   3      S21:  -0.2683 S22:  -0.3072 S23:  -0.0205                       
REMARK   3      S31:  -0.1627 S32:  -0.3336 S33:  -0.0000                       
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 0:5)                                
REMARK   3    ORIGIN FOR THE GROUP (A):  24.2549 -10.3776 219.9587              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1596 T22:   0.1167                                     
REMARK   3      T33:   0.2802 T12:  -0.4051                                     
REMARK   3      T13:  -0.4138 T23:  -0.1812                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0023 L22:   0.0111                                     
REMARK   3      L33:   0.0009 L12:   0.0009                                     
REMARK   3      L13:   0.0007 L23:   0.0001                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1856 S12:  -0.0219 S13:  -0.1305                       
REMARK   3      S21:  -0.0899 S22:  -0.0599 S23:  -0.0815                       
REMARK   3      S31:   0.0680 S32:  -0.0841 S33:   0.0000                       
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 6:12)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  22.2699  -6.6236 227.1601              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9508 T22:   0.6535                                     
REMARK   3      T33:  -0.0598 T12:  -0.6849                                     
REMARK   3      T13:  -0.2910 T23:  -0.3482                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0013 L22:  -0.0023                                     
REMARK   3      L33:   0.0048 L12:   0.0115                                     
REMARK   3      L13:   0.0011 L23:   0.0010                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2495 S12:  -0.0113 S13:  -0.0780                       
REMARK   3      S21:   0.0376 S22:   0.1013 S23:   0.1630                       
REMARK   3      S31:   0.1163 S32:  -0.1687 S33:  -0.0000                       
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 13:26)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  20.2533   2.9293 239.6128              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2593 T22:   0.4841                                     
REMARK   3      T33:  -0.1589 T12:  -2.0974                                     
REMARK   3      T13:  -0.5447 T23:  -1.3251                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0009 L22:  -0.0067                                     
REMARK   3      L33:   0.0032 L12:   0.0313                                     
REMARK   3      L13:   0.0022 L23:   0.0166                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5710 S12:  -0.1473 S13:   0.0060                       
REMARK   3      S21:   0.1550 S22:   0.0272 S23:   0.0032                       
REMARK   3      S31:   0.0548 S32:  -0.2490 S33:  -0.0000                       
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 27:44)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  25.8534  10.9082 260.1938              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7659 T22:   1.1778                                     
REMARK   3      T33:   0.3801 T12:  -0.1809                                     
REMARK   3      T13:   0.1244 T23:  -0.1210                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0450 L22:  -0.0031                                     
REMARK   3      L33:   0.0295 L12:  -0.0514                                     
REMARK   3      L13:  -0.0329 L23:   0.0038                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1181 S12:   0.3038 S13:  -0.1803                       
REMARK   3      S21:   0.3143 S22:  -0.3335 S23:   0.0773                       
REMARK   3      S31:  -0.0244 S32:  -0.1565 S33:   0.0000                       
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 45:53)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  33.9750   9.6743 257.3505              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6110 T22:   0.6577                                     
REMARK   3      T33:   0.5399 T12:  -0.1045                                     
REMARK   3      T13:  -0.0425 T23:  -0.0615                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0072 L22:  -0.0031                                     
REMARK   3      L33:   0.0061 L12:  -0.0114                                     
REMARK   3      L13:  -0.0063 L23:  -0.0039                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1125 S12:  -0.0625 S13:  -0.0859                       
REMARK   3      S21:   0.1420 S22:   0.1418 S23:  -0.0445                       
REMARK   3      S31:   0.2243 S32:   0.0389 S33:   0.0000                       
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 54:73)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  30.9384   4.1086 236.4917              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6336 T22:   0.3800                                     
REMARK   3      T33:   0.2377 T12:  -0.1571                                     
REMARK   3      T13:   0.0138 T23:  -0.0164                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0404 L22:   0.0062                                     
REMARK   3      L33:   0.0045 L12:  -0.0721                                     
REMARK   3      L13:   0.0050 L23:   0.0227                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0702 S12:   0.0149 S13:   0.1665                       
REMARK   3      S21:   0.2592 S22:  -0.2732 S23:   0.1503                       
REMARK   3      S31:   0.2922 S32:  -0.1779 S33:   0.0000                       
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 74:86)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  26.9951  -3.0247 213.4456              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5777 T22:   0.2860                                     
REMARK   3      T33:   0.3337 T12:  -0.0562                                     
REMARK   3      T13:   0.0604 T23:  -0.0045                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0243 L22:   0.0061                                     
REMARK   3      L33:   0.0125 L12:   0.0061                                     
REMARK   3      L13:  -0.0010 L23:   0.0172                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0016 S12:   0.0663 S13:   0.1768                       
REMARK   3      S21:   0.1774 S22:  -0.2151 S23:  -0.0037                       
REMARK   3      S31:   0.2684 S32:   0.1645 S33:  -0.0000                       
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 87:104)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  22.4493  -7.9669 190.6185              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4205 T22:   0.3382                                     
REMARK   3      T33:   0.3829 T12:  -0.0763                                     
REMARK   3      T13:  -0.0079 T23:   0.0154                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0084 L22:   0.0049                                     
REMARK   3      L33:   0.0373 L12:  -0.0210                                     
REMARK   3      L13:  -0.0135 L23:  -0.0530                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0852 S12:   0.1249 S13:   0.0081                       
REMARK   3      S21:   0.0150 S22:  -0.1102 S23:  -0.1170                       
REMARK   3      S31:   0.0846 S32:   0.1366 S33:  -0.0000                       
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 105:116)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  20.1928 -12.0716 169.1486              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5141 T22:   0.2806                                     
REMARK   3      T33:   0.3221 T12:  -0.0019                                     
REMARK   3      T13:   0.0372 T23:  -0.0323                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0142 L22:   0.0137                                     
REMARK   3      L33:   0.0124 L12:   0.0212                                     
REMARK   3      L13:   0.0233 L23:   0.0017                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0474 S12:  -0.1328 S13:  -0.3474                       
REMARK   3      S21:   0.0352 S22:  -0.0539 S23:  -0.0230                       
REMARK   3      S31:   0.3255 S32:  -0.2072 S33:  -0.0000                       
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 117:130)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  45.7899 -18.3926 152.1991              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6475 T22:   0.5236                                     
REMARK   3      T33:   0.3964 T12:   0.1603                                     
REMARK   3      T13:   0.0651 T23:  -0.0567                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0121 L22:   0.0502                                     
REMARK   3      L33:   0.0255 L12:   0.0475                                     
REMARK   3      L13:   0.0371 L23:   0.0511                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0331 S12:   0.1787 S13:   0.0556                       
REMARK   3      S21:   0.0448 S22:  -0.4729 S23:   0.2530                       
REMARK   3      S31:   0.3054 S32:   0.1637 S33:  -0.0000                       
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 131:139)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  62.3924 -31.4955 130.1721              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5959 T22:   0.4710                                     
REMARK   3      T33:   0.6580 T12:   0.1896                                     
REMARK   3      T13:   0.0723 T23:   0.0073                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0018 L22:  -0.0064                                     
REMARK   3      L33:   0.0018 L12:   0.0064                                     
REMARK   3      L13:   0.0053 L23:   0.0204                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1107 S12:  -0.2667 S13:  -0.3747                       
REMARK   3      S21:   0.1926 S22:   0.1475 S23:  -0.2835                       
REMARK   3      S31:  -0.0913 S32:  -0.0315 S33:   0.0000                       
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 140:155)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  50.0041 -44.5415 116.4606              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.9882 T22:  -0.4598                                     
REMARK   3      T33:  -0.3385 T12:   1.5338                                     
REMARK   3      T13:   0.9814 T23:  -0.8732                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0735 L22:   0.0196                                     
REMARK   3      L33:  -0.0484 L12:   0.1111                                     
REMARK   3      L13:   0.0987 L23:  -0.0039                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2485 S12:   1.5571 S13:  -1.2692                       
REMARK   3      S21:  -0.4791 S22:   0.0075 S23:  -0.2084                       
REMARK   3      S31:   0.8753 S32:   1.4362 S33:  -0.0000                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4N78 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-NOV-13.                  
REMARK 100 THE RCSB ID CODE IS RCSB082839.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 12-JAN-10                          
REMARK 200  TEMPERATURE           (KELVIN) : 173                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 19-ID                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9796                             
REMARK 200  MONOCHROMATOR                  : SAGITALLY FOCUSED SI(111)          
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R                  
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 262551                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.430                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.43                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.48                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.0                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 45.33                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.25                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 10% GLYCEROL, 4% PEG 10,000, 12-20%      
REMARK 280  PEG 300, 100 MM TRIS-HCL, 2MM EDTA, 2 MM TCEP, PH 8.5,              
REMARK 280  EVAPORATION, TEMPERATURE 277K                                       
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       48.74600            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      161.80250            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       57.37500            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      161.80250            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       48.74600            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       57.37500            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 44400 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 111240 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -268.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, D, F, E, P                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     GLN A     4                                                      
REMARK 465     PRO A    23                                                      
REMARK 465     ASP A    24                                                      
REMARK 465     GLN A    25                                                      
REMARK 465     GLN A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     CYS A    28                                                      
REMARK 465     ILE A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     PRO A    31                                                      
REMARK 465     PRO A    32                                                      
REMARK 465     PRO A    33                                                      
REMARK 465     SER A    34                                                      
REMARK 465     SER A    35                                                      
REMARK 465     LEU A    36                                                      
REMARK 465     LEU A    37                                                      
REMARK 465     TYR A    38                                                      
REMARK 465     GLN A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     ASN A    41                                                      
REMARK 465     PHE A    42                                                      
REMARK 465     ASN A    43                                                      
REMARK 465     THR A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     PHE A    46                                                      
REMARK 465     GLU A    47                                                      
REMARK 465     ASP A    48                                                      
REMARK 465     ARG A    49                                                      
REMARK 465     ASN A    50                                                      
REMARK 465     ALA A    51                                                      
REMARK 465     PHE A    52                                                      
REMARK 465     VAL A    53                                                      
REMARK 465     THR A    54                                                      
REMARK 465     ASN A   368                                                      
REMARK 465     SER A   369                                                      
REMARK 465     GLU A   370                                                      
REMARK 465     VAL A   371                                                      
REMARK 465     VAL A   372                                                      
REMARK 465     THR A   373                                                      
REMARK 465     GLY A   374                                                      
REMARK 465     SER A   375                                                      
REMARK 465     GLY A   376                                                      
REMARK 465     ARG A   377                                                      
REMARK 465     GLN A   378                                                      
REMARK 465     GLU A   379                                                      
REMARK 465     LYS A   540                                                      
REMARK 465     SER A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     ASP A   572                                                      
REMARK 465     LYS A   573                                                      
REMARK 465     SER A   574                                                      
REMARK 465     GLY A   575                                                      
REMARK 465     SER A   576                                                      
REMARK 465     LYS A   577                                                      
REMARK 465     SER A  1228                                                      
REMARK 465     GLY A  1229                                                      
REMARK 465     ASP A  1230                                                      
REMARK 465     GLY A  1231                                                      
REMARK 465     GLU A  1232                                                      
REMARK 465     GLY A  1233                                                      
REMARK 465     THR A  1234                                                      
REMARK 465     PRO A  1235                                                      
REMARK 465     VAL A  1236                                                      
REMARK 465     ALA A  1251                                                      
REMARK 465     SER A  1252                                                      
REMARK 465     SER A  1253                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     ARG B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     LEU B     6                                                      
REMARK 465     GLU B    68                                                      
REMARK 465     THR B    69                                                      
REMARK 465     ARG B    70                                                      
REMARK 465     ASN B    71                                                      
REMARK 465     ASN B    72                                                      
REMARK 465     ASN B    73                                                      
REMARK 465     GLN B    74                                                      
REMARK 465     GLN B    75                                                      
REMARK 465     LYS B   644                                                      
REMARK 465     SER B   645                                                      
REMARK 465     LYS B   646                                                      
REMARK 465     LYS B   647                                                      
REMARK 465     GLN B   648                                                      
REMARK 465     THR B   649                                                      
REMARK 465     GLY B   650                                                      
REMARK 465     LYS B   651                                                      
REMARK 465     LYS B   652                                                      
REMARK 465     GLY B   653                                                      
REMARK 465     GLU B   654                                                      
REMARK 465     PRO B   655                                                      
REMARK 465     GLU B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ARG B   948                                                      
REMARK 465     GLU B   949                                                      
REMARK 465     GLN B   982                                                      
REMARK 465     LYS B   983                                                      
REMARK 465     SER B   984                                                      
REMARK 465     GLU B   985                                                      
REMARK 465     ASN B   986                                                      
REMARK 465     ILE B   987                                                      
REMARK 465     GLN B  1122                                                      
REMARK 465     SER B  1123                                                      
REMARK 465     VAL B  1124                                                      
REMARK 465     THR B  1125                                                      
REMARK 465     SER B  1126                                                      
REMARK 465     SER B  1127                                                      
REMARK 465     ALA B  1128                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     VAL D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     ARG D     6                                                      
REMARK 465     ASN D     7                                                      
REMARK 465     ILE D     8                                                      
REMARK 465     ASP D     9                                                      
REMARK 465     PRO D    10                                                      
REMARK 465     ARG D    11                                                      
REMARK 465     HIS D    12                                                      
REMARK 465     LEU D    13                                                      
REMARK 465     CYS D    14                                                      
REMARK 465     LYS D   178                                                      
REMARK 465     GLN D   179                                                      
REMARK 465     LYS D   180                                                      
REMARK 465     GLN D   181                                                      
REMARK 465     LYS D   182                                                      
REMARK 465     ASN D   183                                                      
REMARK 465     LEU D   184                                                      
REMARK 465     ASP D   185                                                      
REMARK 465     ARG D   186                                                      
REMARK 465     PRO D   187                                                      
REMARK 465     HIS D   188                                                      
REMARK 465     GLU D   189                                                      
REMARK 465     PRO D   190                                                      
REMARK 465     GLU D   191                                                      
REMARK 465     LYS D   192                                                      
REMARK 465     VAL D   193                                                      
REMARK 465     PRO D   194                                                      
REMARK 465     ARG D   195                                                      
REMARK 465     ALA D   196                                                      
REMARK 465     PRO D   197                                                      
REMARK 465     HIS D   198                                                      
REMARK 465     ASP D   199                                                      
REMARK 465     ARG D   200                                                      
REMARK 465     ARG D   201                                                      
REMARK 465     ARG D   202                                                      
REMARK 465     GLU D   203                                                      
REMARK 465     TRP D   204                                                      
REMARK 465     GLN D   205                                                      
REMARK 465     LYS D   206                                                      
REMARK 465     LEU D   207                                                      
REMARK 465     ALA D   208                                                      
REMARK 465     GLN D   209                                                      
REMARK 465     GLY D   210                                                      
REMARK 465     PRO D   211                                                      
REMARK 465     GLU D   212                                                      
REMARK 465     LEU D   213                                                      
REMARK 465     ALA D   214                                                      
REMARK 465     GLU D   215                                                      
REMARK 465     ASP D   216                                                      
REMARK 465     ASP D   217                                                      
REMARK 465     ALA D   218                                                      
REMARK 465     ASN D   219                                                      
REMARK 465     LEU D   220                                                      
REMARK 465     LEU D   221                                                      
REMARK 465     HIS D   222                                                      
REMARK 465     LYS D   223                                                      
REMARK 465     HIS D   224                                                      
REMARK 465     ILE D   225                                                      
REMARK 465     GLU D   226                                                      
REMARK 465     VAL D   227                                                      
REMARK 465     ALA D   228                                                      
REMARK 465     ASN D   229                                                      
REMARK 465     GLY D   230                                                      
REMARK 465     PRO D   231                                                      
REMARK 465     ALA D   232                                                      
REMARK 465     SER D   233                                                      
REMARK 465     HIS D   234                                                      
REMARK 465     PHE D   235                                                      
REMARK 465     GLU D   236                                                      
REMARK 465     THR D   237                                                      
REMARK 465     ARG D   238                                                      
REMARK 465     PRO D   239                                                      
REMARK 465     GLN D   240                                                      
REMARK 465     THR D   241                                                      
REMARK 465     TYR D   242                                                      
REMARK 465     VAL D   243                                                      
REMARK 465     ASP D   244                                                      
REMARK 465     HIS D   245                                                      
REMARK 465     MET D   246                                                      
REMARK 465     ASP D   247                                                      
REMARK 465     GLY D   248                                                      
REMARK 465     SER D   249                                                      
REMARK 465     TYR D   250                                                      
REMARK 465     SER D   251                                                      
REMARK 465     LEU D   252                                                      
REMARK 465     SER D   253                                                      
REMARK 465     ALA D   254                                                      
REMARK 465     LEU D   255                                                      
REMARK 465     PRO D   256                                                      
REMARK 465     PHE D   257                                                      
REMARK 465     SER D   258                                                      
REMARK 465     GLN D   259                                                      
REMARK 465     MET D   260                                                      
REMARK 465     SER D   261                                                      
REMARK 465     GLU D   262                                                      
REMARK 465     LEU D   263                                                      
REMARK 465     LEU D   264                                                      
REMARK 465     THR D   265                                                      
REMARK 465     ARG D   266                                                      
REMARK 465     ALA D   267                                                      
REMARK 465     GLU D   268                                                      
REMARK 465     GLU D   269                                                      
REMARK 465     ARG D   270                                                      
REMARK 465     VAL D   271                                                      
REMARK 465     LEU D   272                                                      
REMARK 465     VAL D   273                                                      
REMARK 465     ARG D   274                                                      
REMARK 465     PRO D   275                                                      
REMARK 465     HIS D   276                                                      
REMARK 465     GLU D   277                                                      
REMARK 465     PRO D   278                                                      
REMARK 465     PRO D   279                                                      
REMARK 465     PRO D   280                                                      
REMARK 465     PRO D   281                                                      
REMARK 465     PRO D   282                                                      
REMARK 465     PRO D   283                                                      
REMARK 465     MET D   284                                                      
REMARK 465     HIS D   285                                                      
REMARK 465     GLY D   286                                                      
REMARK 465     ALA D   287                                                      
REMARK 465     GLY D   288                                                      
REMARK 465     ASP D   289                                                      
REMARK 465     ALA D   290                                                      
REMARK 465     LYS D   291                                                      
REMARK 465     PRO D   292                                                      
REMARK 465     ILE D   293                                                      
REMARK 465     PRO D   294                                                      
REMARK 465     THR D   295                                                      
REMARK 465     CYS D   296                                                      
REMARK 465     ILE D   297                                                      
REMARK 465     SER D   298                                                      
REMARK 465     SER D   299                                                      
REMARK 465     ALA D   300                                                      
REMARK 465     THR D   301                                                      
REMARK 465     GLY D   302                                                      
REMARK 465     LEU D   303                                                      
REMARK 465     ILE D   304                                                      
REMARK 465     GLU D   305                                                      
REMARK 465     ASN D   306                                                      
REMARK 465     ARG D   307                                                      
REMARK 465     PRO D   308                                                      
REMARK 465     GLN D   309                                                      
REMARK 465     SER D   310                                                      
REMARK 465     PRO D   311                                                      
REMARK 465     ALA D   312                                                      
REMARK 465     THR D   313                                                      
REMARK 465     GLY D   314                                                      
REMARK 465     ARG D   315                                                      
REMARK 465     THR D   316                                                      
REMARK 465     PRO D   317                                                      
REMARK 465     VAL D   318                                                      
REMARK 465     PHE D   319                                                      
REMARK 465     VAL D   320                                                      
REMARK 465     SER D   321                                                      
REMARK 465     PRO D   322                                                      
REMARK 465     THR D   323                                                      
REMARK 465     PRO D   324                                                      
REMARK 465     PRO D   325                                                      
REMARK 465     PRO D   326                                                      
REMARK 465     PRO D   327                                                      
REMARK 465     PRO D   328                                                      
REMARK 465     PRO D   329                                                      
REMARK 465     PRO D   330                                                      
REMARK 465     LEU D   331                                                      
REMARK 465     PRO D   332                                                      
REMARK 465     SER D   333                                                      
REMARK 465     ALA D   334                                                      
REMARK 465     LEU D   335                                                      
REMARK 465     SER D   336                                                      
REMARK 465     THR D   337                                                      
REMARK 465     SER D   338                                                      
REMARK 465     SER D   339                                                      
REMARK 465     LEU D   340                                                      
REMARK 465     ARG D   341                                                      
REMARK 465     ALA D   342                                                      
REMARK 465     SER D   343                                                      
REMARK 465     MET D   344                                                      
REMARK 465     THR D   345                                                      
REMARK 465     SER D   346                                                      
REMARK 465     THR D   347                                                      
REMARK 465     PRO D   348                                                      
REMARK 465     PRO D   349                                                      
REMARK 465     PRO D   350                                                      
REMARK 465     PRO D   351                                                      
REMARK 465     VAL D   352                                                      
REMARK 465     PRO D   353                                                      
REMARK 465     PRO D   354                                                      
REMARK 465     PRO D   355                                                      
REMARK 465     PRO D   356                                                      
REMARK 465     PRO D   357                                                      
REMARK 465     PRO D   358                                                      
REMARK 465     PRO D   359                                                      
REMARK 465     ALA D   360                                                      
REMARK 465     THR D   361                                                      
REMARK 465     ALA D   362                                                      
REMARK 465     LEU D   363                                                      
REMARK 465     GLN D   364                                                      
REMARK 465     ALA D   365                                                      
REMARK 465     PRO D   366                                                      
REMARK 465     ALA D   367                                                      
REMARK 465     VAL D   368                                                      
REMARK 465     PRO D   369                                                      
REMARK 465     PRO D   370                                                      
REMARK 465     PRO D   371                                                      
REMARK 465     PRO D   372                                                      
REMARK 465     ALA D   373                                                      
REMARK 465     PRO D   374                                                      
REMARK 465     LEU D   375                                                      
REMARK 465     GLN D   376                                                      
REMARK 465     ILE D   377                                                      
REMARK 465     ALA D   378                                                      
REMARK 465     PRO D   379                                                      
REMARK 465     GLY D   380                                                      
REMARK 465     VAL D   381                                                      
REMARK 465     LEU D   382                                                      
REMARK 465     HIS D   383                                                      
REMARK 465     PRO D   384                                                      
REMARK 465     ALA D   385                                                      
REMARK 465     PRO D   386                                                      
REMARK 465     PRO D   387                                                      
REMARK 465     PRO D   388                                                      
REMARK 465     ILE D   389                                                      
REMARK 465     ALA D   390                                                      
REMARK 465     PRO D   391                                                      
REMARK 465     PRO D   392                                                      
REMARK 465     LEU D   393                                                      
REMARK 465     VAL D   394                                                      
REMARK 465     GLN D   395                                                      
REMARK 465     PRO D   396                                                      
REMARK 465     SER D   397                                                      
REMARK 465     PRO D   398                                                      
REMARK 465     PRO D   399                                                      
REMARK 465     VAL D   400                                                      
REMARK 465     ALA D   401                                                      
REMARK 465     ARG D   402                                                      
REMARK 465     ALA D   403                                                      
REMARK 465     ALA D   404                                                      
REMARK 465     PRO D   405                                                      
REMARK 465     VAL D   406                                                      
REMARK 465     CYS D   407                                                      
REMARK 465     GLU D   408                                                      
REMARK 465     THR D   409                                                      
REMARK 465     VAL D   410                                                      
REMARK 465     PRO D   411                                                      
REMARK 465     VAL D   412                                                      
REMARK 465     HIS D   413                                                      
REMARK 465     PRO D   414                                                      
REMARK 465     LEU D   415                                                      
REMARK 465     PRO D   416                                                      
REMARK 465     GLN D   417                                                      
REMARK 465     GLY D   418                                                      
REMARK 465     GLU D   419                                                      
REMARK 465     VAL D   420                                                      
REMARK 465     GLN D   421                                                      
REMARK 465     GLY D   422                                                      
REMARK 465     LEU D   423                                                      
REMARK 465     PRO D   424                                                      
REMARK 465     PRO D   425                                                      
REMARK 465     PRO D   426                                                      
REMARK 465     PRO D   427                                                      
REMARK 465     PRO D   428                                                      
REMARK 465     PRO D   429                                                      
REMARK 465     PRO D   430                                                      
REMARK 465     PRO D   431                                                      
REMARK 465     LEU D   432                                                      
REMARK 465     PRO D   433                                                      
REMARK 465     PRO D   434                                                      
REMARK 465     PRO D   435                                                      
REMARK 465     GLY D   436                                                      
REMARK 465     ILE D   437                                                      
REMARK 465     ARG D   438                                                      
REMARK 465     PRO D   439                                                      
REMARK 465     SER D   440                                                      
REMARK 465     SER D   441                                                      
REMARK 465     PRO D   442                                                      
REMARK 465     VAL D   443                                                      
REMARK 465     THR D   444                                                      
REMARK 465     VAL D   445                                                      
REMARK 465     THR D   446                                                      
REMARK 465     ALA D   447                                                      
REMARK 465     LEU D   448                                                      
REMARK 465     ALA D   449                                                      
REMARK 465     HIS D   450                                                      
REMARK 465     PRO D   451                                                      
REMARK 465     PRO D   452                                                      
REMARK 465     SER D   453                                                      
REMARK 465     GLY D   454                                                      
REMARK 465     LEU D   455                                                      
REMARK 465     HIS D   456                                                      
REMARK 465     PRO D   457                                                      
REMARK 465     THR D   458                                                      
REMARK 465     PRO D   459                                                      
REMARK 465     SER D   460                                                      
REMARK 465     THR D   461                                                      
REMARK 465     ALA D   462                                                      
REMARK 465     PRO D   463                                                      
REMARK 465     GLY D   464                                                      
REMARK 465     PRO D   465                                                      
REMARK 465     HIS D   466                                                      
REMARK 465     VAL D   467                                                      
REMARK 465     PRO D   468                                                      
REMARK 465     LEU D   469                                                      
REMARK 465     MET D   470                                                      
REMARK 465     PRO D   471                                                      
REMARK 465     PRO D   472                                                      
REMARK 465     SER D   473                                                      
REMARK 465     PRO D   474                                                      
REMARK 465     PRO D   475                                                      
REMARK 465     SER D   476                                                      
REMARK 465     GLN D   477                                                      
REMARK 465     VAL D   478                                                      
REMARK 465     ILE D   479                                                      
REMARK 465     PRO D   480                                                      
REMARK 465     ALA D   481                                                      
REMARK 465     SER D   482                                                      
REMARK 465     GLU D   483                                                      
REMARK 465     PRO D   484                                                      
REMARK 465     LYS D   485                                                      
REMARK 465     ARG D   486                                                      
REMARK 465     HIS D   487                                                      
REMARK 465     PRO D   488                                                      
REMARK 465     SER D   489                                                      
REMARK 465     THR D   490                                                      
REMARK 465     LEU D   491                                                      
REMARK 465     PRO D   492                                                      
REMARK 465     VAL D   493                                                      
REMARK 465     ILE D   494                                                      
REMARK 465     GLN D   517                                                      
REMARK 465     ARG D   518                                                      
REMARK 465     GLU D   519                                                      
REMARK 465     GLN D   520                                                      
REMARK 465     GLU D   521                                                      
REMARK 465     ALA D   522                                                      
REMARK 465     LYS D   523                                                      
REMARK 465     HIS D   524                                                      
REMARK 465     GLU D   525                                                      
REMARK 465     ARG D   526                                                      
REMARK 465     SER D   544                                                      
REMARK 465     ASP D   545                                                      
REMARK 465     SER D   546                                                      
REMARK 465     GLU D   547                                                      
REMARK 465     ASP D   548                                                      
REMARK 465     ASP D   549                                                      
REMARK 465     SER D   550                                                      
REMARK 465     GLU D   551                                                      
REMARK 465     PHE D   552                                                      
REMARK 465     ASP D   553                                                      
REMARK 465     GLU D   554                                                      
REMARK 465     VAL D   555                                                      
REMARK 465     ASP D   556                                                      
REMARK 465     TRP D   557                                                      
REMARK 465     LEU D   558                                                      
REMARK 465     GLU D   559                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     GLN E     4                                                      
REMARK 465     GLU E     5                                                      
REMARK 465     THR E    73                                                      
REMARK 465     LEU E    74                                                      
REMARK 465     THR E    75                                                      
REMARK 465     LEU F   156                                                      
REMARK 465     LEU F   157                                                      
REMARK 465     ARG F   158                                                      
REMARK 465     PHE F   159                                                      
REMARK 465     LYS F   160                                                      
REMARK 465     VAL F   161                                                      
REMARK 465     SER F   162                                                      
REMARK 465     THR F   163                                                      
REMARK 465     GLN F   164                                                      
REMARK 465     ASN F   165                                                      
REMARK 465     MET F   166                                                      
REMARK 465     LYS F   167                                                      
REMARK 465     MET F   168                                                      
REMARK 465     GLY F   169                                                      
REMARK 465     GLY F   170                                                      
REMARK 465     LEU F   171                                                      
REMARK 465     PRO F   172                                                      
REMARK 465     ARG F   173                                                      
REMARK 465     THR F   174                                                      
REMARK 465     THR F   175                                                      
REMARK 465     PRO F   176                                                      
REMARK 465     PRO F   177                                                      
REMARK 465     THR F   178                                                      
REMARK 465     GLN F   179                                                      
REMARK 465     LYS F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     PRO F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     PRO F   184                                                      
REMARK 465     PRO F   185                                                      
REMARK 465     MET F   186                                                      
REMARK 465     SER F   187                                                      
REMARK 465     GLY F   188                                                      
REMARK 465     LYS F   189                                                      
REMARK 465     GLY F   190                                                      
REMARK 465     THR F   191                                                      
REMARK 465     LEU F   192                                                      
REMARK 465     GLY F   193                                                      
REMARK 465     ARG F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     SER F   196                                                      
REMARK 465     PRO F   197                                                      
REMARK 465     TYR F   198                                                      
REMARK 465     ARG F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     LEU F   201                                                      
REMARK 465     GLU F   202                                                      
REMARK 465     PRO F   203                                                      
REMARK 465     VAL F   204                                                      
REMARK 465     ARG F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     PRO F   207                                                      
REMARK 465     VAL F   208                                                      
REMARK 465     VAL F   209                                                      
REMARK 465     PRO F   210                                                      
REMARK 465     ASN F   211                                                      
REMARK 465     ASP F   212                                                      
REMARK 465     TYR F   213                                                      
REMARK 465     VAL F   214                                                      
REMARK 465     PRO F   215                                                      
REMARK 465     SER F   216                                                      
REMARK 465     PRO F   217                                                      
REMARK 465     THR F   218                                                      
REMARK 465     ARG F   219                                                      
REMARK 465     ASN F   220                                                      
REMARK 465     MET F   221                                                      
REMARK 465     ALA F   222                                                      
REMARK 465     PRO F   223                                                      
REMARK 465     SER F   224                                                      
REMARK 465     GLN F   225                                                      
REMARK 465     GLN F   226                                                      
REMARK 465     SER F   227                                                      
REMARK 465     PRO F   228                                                      
REMARK 465     VAL F   229                                                      
REMARK 465     ARG F   230                                                      
REMARK 465     THR F   231                                                      
REMARK 465     ALA F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     VAL F   234                                                      
REMARK 465     ASN F   235                                                      
REMARK 465     GLN F   236                                                      
REMARK 465     ARG F   237                                                      
REMARK 465     ASN F   238                                                      
REMARK 465     ARG F   239                                                      
REMARK 465     THR F   240                                                      
REMARK 465     TYR F   241                                                      
REMARK 465     SER F   242                                                      
REMARK 465     SER F   243                                                      
REMARK 465     SER F   244                                                      
REMARK 465     GLY F   245                                                      
REMARK 465     SER F   246                                                      
REMARK 465     SER F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     GLY F   249                                                      
REMARK 465     SER F   250                                                      
REMARK 465     HIS F   251                                                      
REMARK 465     PRO F   252                                                      
REMARK 465     SER F   253                                                      
REMARK 465     SER F   254                                                      
REMARK 465     ARG F   255                                                      
REMARK 465     SER F   256                                                      
REMARK 465     SER F   257                                                      
REMARK 465     SER F   258                                                      
REMARK 465     ARG F   259                                                      
REMARK 465     GLU F   260                                                      
REMARK 465     ASN F   261                                                      
REMARK 465     SER F   262                                                      
REMARK 465     GLY F   263                                                      
REMARK 465     SER F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     SER F   266                                                      
REMARK 465     VAL F   267                                                      
REMARK 465     GLY F   268                                                      
REMARK 465     VAL F   269                                                      
REMARK 465     PRO F   270                                                      
REMARK 465     ILE F   271                                                      
REMARK 465     ALA F   272                                                      
REMARK 465     VAL F   273                                                      
REMARK 465     PRO F   274                                                      
REMARK 465     THR F   275                                                      
REMARK 465     PRO F   276                                                      
REMARK 465     SER F   277                                                      
REMARK 465     PRO F   278                                                      
REMARK 465     PRO F   279                                                      
REMARK 465     SER F   280                                                      
REMARK 465     VAL F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     PRO F   283                                                      
REMARK 465     ALA F   284                                                      
REMARK 465     PRO F   285                                                      
REMARK 465     ALA F   286                                                      
REMARK 465     GLY F   287                                                      
REMARK 465     SER F   288                                                      
REMARK 465     ALA F   289                                                      
REMARK 465     GLY F   290                                                      
REMARK 465     THR F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     PRO F   293                                                      
REMARK 465     LEU F   294                                                      
REMARK 465     PRO F   295                                                      
REMARK 465     ALA F   296                                                      
REMARK 465     THR F   297                                                      
REMARK 465     SER F   298                                                      
REMARK 465     ALA F   299                                                      
REMARK 465     SER F   300                                                      
REMARK 465     ALA F   301                                                      
REMARK 465     PRO F   302                                                      
REMARK 465     ALA F   303                                                      
REMARK 465     PRO F   304                                                      
REMARK 465     LEU F   305                                                      
REMARK 465     VAL F   306                                                      
REMARK 465     PRO F   307                                                      
REMARK 465     ALA F   308                                                      
REMARK 465     THR F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     SER F   313                                                      
REMARK 465     THR F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     ASP F   317                                                      
REMARK 465     ALA F   318                                                      
REMARK 465     ALA F   319                                                      
REMARK 465     ALA F   320                                                      
REMARK 465     GLY F   321                                                      
REMARK 465     GLY F   322                                                      
REMARK 465     ALA F   323                                                      
REMARK 465     GLN F   324                                                      
REMARK 465     THR F   325                                                      
REMARK 465     LEU F   326                                                      
REMARK 465     ALA F   327                                                      
REMARK 465     ASP F   328                                                      
REMARK 465     GLY F   329                                                      
REMARK 465     PHE F   330                                                      
REMARK 465     THR F   331                                                      
REMARK 465     SER F   332                                                      
REMARK 465     PRO F   333                                                      
REMARK 465     THR F   334                                                      
REMARK 465     PRO F   335                                                      
REMARK 465     PRO F   336                                                      
REMARK 465     VAL F   337                                                      
REMARK 465     VAL F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     SER F   340                                                      
REMARK 465     THR F   341                                                      
REMARK 465     PRO F   342                                                      
REMARK 465     PRO F   343                                                      
REMARK 465     THR F   344                                                      
REMARK 465     GLY F   345                                                      
REMARK 465     HIS F   346                                                      
REMARK 465     PRO F   347                                                      
REMARK 465     VAL F   348                                                      
REMARK 465     GLN F   349                                                      
REMARK 465     PHE F   350                                                      
REMARK 465     TYR F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     MET F   353                                                      
REMARK 465     ASN F   354                                                      
REMARK 465     ARG F   355                                                      
REMARK 465     PRO F   356                                                      
REMARK 465     ALA F   357                                                      
REMARK 465     SER F   358                                                      
REMARK 465     ARG F   359                                                      
REMARK 465     HIS F   360                                                      
REMARK 465     THR F   361                                                      
REMARK 465     PRO F   362                                                      
REMARK 465     PRO F   363                                                      
REMARK 465     THR F   364                                                      
REMARK 465     ILE F   365                                                      
REMARK 465     GLY F   366                                                      
REMARK 465     GLY F   367                                                      
REMARK 465     SER F   368                                                      
REMARK 465     LEU F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     TYR F   371                                                      
REMARK 465     ARG F   372                                                      
REMARK 465     ARG F   373                                                      
REMARK 465     PRO F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     SER F   376                                                      
REMARK 465     ILE F   377                                                      
REMARK 465     THR F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     GLN F   380                                                      
REMARK 465     THR F   381                                                      
REMARK 465     SER F   382                                                      
REMARK 465     LEU F   383                                                      
REMARK 465     GLN F   384                                                      
REMARK 465     ASN F   385                                                      
REMARK 465     GLN F   386                                                      
REMARK 465     MET F   387                                                      
REMARK 465     ASN F   388                                                      
REMARK 465     GLY F   389                                                      
REMARK 465     GLY F   390                                                      
REMARK 465     PRO F   391                                                      
REMARK 465     PHE F   392                                                      
REMARK 465     TYR F   393                                                      
REMARK 465     SER F   394                                                      
REMARK 465     GLN F   395                                                      
REMARK 465     ASN F   396                                                      
REMARK 465     PRO F   397                                                      
REMARK 465     VAL F   398                                                      
REMARK 465     SER F   399                                                      
REMARK 465     ASP F   400                                                      
REMARK 465     THR F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     PRO F   403                                                      
REMARK 465     PRO F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     PRO F   406                                                      
REMARK 465     PRO F   407                                                      
REMARK 465     VAL F   408                                                      
REMARK 465     GLU F   409                                                      
REMARK 465     GLU F   410                                                      
REMARK 465     PRO F   411                                                      
REMARK 465     VAL F   412                                                      
REMARK 465     PHE F   413                                                      
REMARK 465     ASP F   414                                                      
REMARK 465     GLU F   415                                                      
REMARK 465     SER F   416                                                      
REMARK 465     PRO F   417                                                      
REMARK 465     PRO F   418                                                      
REMARK 465     PRO F   419                                                      
REMARK 465     PRO F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     PRO F   422                                                      
REMARK 465     PRO F   423                                                      
REMARK 465     GLU F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     TYR F   426                                                      
REMARK 465     GLU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     GLU F   429                                                      
REMARK 465     GLU F   430                                                      
REMARK 465     ALA F   431                                                      
REMARK 465     ALA F   432                                                      
REMARK 465     VAL F   433                                                      
REMARK 465     VAL F   434                                                      
REMARK 465     GLU F   435                                                      
REMARK 465     TYR F   436                                                      
REMARK 465     SER F   437                                                      
REMARK 465     ASP F   438                                                      
REMARK 465     PRO F   439                                                      
REMARK 465     TYR F   440                                                      
REMARK 465     ALA F   441                                                      
REMARK 465     GLU F   442                                                      
REMARK 465     GLU F   443                                                      
REMARK 465     ASP F   444                                                      
REMARK 465     PRO F   445                                                      
REMARK 465     PRO F   446                                                      
REMARK 465     TRP F   447                                                      
REMARK 465     ALA F   448                                                      
REMARK 465     PRO F   449                                                      
REMARK 465     ARG F   450                                                      
REMARK 465     SER F   451                                                      
REMARK 465     TYR F   452                                                      
REMARK 465     LEU F   453                                                      
REMARK 465     GLU F   454                                                      
REMARK 465     LYS F   455                                                      
REMARK 465     VAL F   456                                                      
REMARK 465     VAL F   457                                                      
REMARK 465     ALA F   458                                                      
REMARK 465     ILE F   459                                                      
REMARK 465     TYR F   460                                                      
REMARK 465     ASP F   461                                                      
REMARK 465     TYR F   462                                                      
REMARK 465     THR F   463                                                      
REMARK 465     LYS F   464                                                      
REMARK 465     ASP F   465                                                      
REMARK 465     LYS F   466                                                      
REMARK 465     GLU F   467                                                      
REMARK 465     ASP F   468                                                      
REMARK 465     GLU F   469                                                      
REMARK 465     LEU F   470                                                      
REMARK 465     SER F   471                                                      
REMARK 465     PHE F   472                                                      
REMARK 465     GLN F   473                                                      
REMARK 465     GLU F   474                                                      
REMARK 465     GLY F   475                                                      
REMARK 465     ALA F   476                                                      
REMARK 465     ILE F   477                                                      
REMARK 465     ILE F   478                                                      
REMARK 465     TYR F   479                                                      
REMARK 465     VAL F   480                                                      
REMARK 465     ILE F   481                                                      
REMARK 465     LYS F   482                                                      
REMARK 465     LYS F   483                                                      
REMARK 465     ASN F   484                                                      
REMARK 465     ASP F   485                                                      
REMARK 465     ASP F   486                                                      
REMARK 465     GLY F   487                                                      
REMARK 465     TRP F   488                                                      
REMARK 465     TYR F   489                                                      
REMARK 465     GLU F   490                                                      
REMARK 465     GLY F   491                                                      
REMARK 465     VAL F   492                                                      
REMARK 465     MET F   493                                                      
REMARK 465     ASN F   494                                                      
REMARK 465     GLY F   495                                                      
REMARK 465     VAL F   496                                                      
REMARK 465     THR F   497                                                      
REMARK 465     GLY F   498                                                      
REMARK 465     LEU F   499                                                      
REMARK 465     PHE F   500                                                      
REMARK 465     PRO F   501                                                      
REMARK 465     GLY F   502                                                      
REMARK 465     ASN F   503                                                      
REMARK 465     TYR F   504                                                      
REMARK 465     VAL F   505                                                      
REMARK 465     GLU F   506                                                      
REMARK 465     SER F   507                                                      
REMARK 465     ILE F   508                                                      
REMARK 465     MET F   509                                                      
REMARK 465     HIS F   510                                                      
REMARK 465     TYR F   511                                                      
REMARK 465     SER F   512                                                      
REMARK 465     GLU F   513                                                      
REMARK 465     TRP P     1                                                      
REMARK 465     GLY P     2                                                      
REMARK 465     ALA P     3                                                      
REMARK 465     GLU P     4                                                      
REMARK 465     GLU P    13                                                      
REMARK 465     LYS P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 480                                                                      
REMARK 480 ZERO OCCUPANCY ATOM                                                  
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO                  
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS                
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;              
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):         
REMARK 480   M RES C SSEQI ATOMS                                                
REMARK 480     THR A  321   N    CA   C    O    CB   OG1  CG2                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OH   TYR A  1225     OD1  ASN B   755              2.12            
REMARK 500   OE2  GLU A   932     OG   SER D   499              2.12            
REMARK 500   O    MET A   212     ND2  ASN A   216              2.14            
REMARK 500   OD2  ASP B   105     NH2  ARG B   177              2.18            
REMARK 500   OD1  ASN B   766     O    HOH B  1551              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PHE A 308      124.20   -173.13                                   
REMARK 500    SER A 337      -68.66   -122.35                                   
REMARK 500    TYR A 366       53.28   -106.80                                   
REMARK 500    THR A 439      -84.31   -116.92                                   
REMARK 500    ALA A 551       51.48   -106.83                                   
REMARK 500    ASN A 607       54.02    -97.42                                   
REMARK 500    ARG A 624       41.59   -154.57                                   
REMARK 500    HIS A 754       81.24   -152.35                                   
REMARK 500    ASP A 850      -59.92   -131.12                                   
REMARK 500    LEU A 888     -107.52   -118.28                                   
REMARK 500    VAL A 992      -60.88   -121.76                                   
REMARK 500    LYS A1038     -167.60    -79.20                                   
REMARK 500    LEU A1104       52.44   -112.81                                   
REMARK 500    VAL A1118      -68.49   -125.96                                   
REMARK 500    VAL A1121      -54.61   -129.17                                   
REMARK 500    CYS A1124       71.87   -112.33                                   
REMARK 500    PRO A1200      109.08    -57.73                                   
REMARK 500    PRO B  41        3.64    -56.78                                   
REMARK 500    PHE B  64      133.04    -37.52                                   
REMARK 500    VAL B 125      -73.69   -130.01                                   
REMARK 500    VAL B 213      -62.49   -131.66                                   
REMARK 500    ARG B 297     -121.40     57.68                                   
REMARK 500    ILE B 314     -165.11   -115.79                                   
REMARK 500    ARG B 315      -82.07   -117.80                                   
REMARK 500    CYS B 452      119.87   -172.04                                   
REMARK 500    GLN B 758       71.65    -63.76                                   
REMARK 500    SER B 883       40.78    -97.08                                   
REMARK 500    HIS B 945       54.29   -109.24                                   
REMARK 500    PHE B1107       95.54   -165.11                                   
REMARK 500    THR D  16      -82.33   -143.09                                   
REMARK 500    ALA D  17     -167.57   -120.18                                   
REMARK 500    PRO D 133       60.01    -67.20                                   
REMARK 500    ASN D 529       37.35    -86.62                                   
REMARK 500    GLU F  10      -57.61   -134.45                                   
REMARK 500    ASN F 117       78.48    -63.78                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH A1682        DISTANCE =  5.28 ANGSTROMS                       
REMARK 525    HOH B1582        DISTANCE =  5.36 ANGSTROMS                       
REMARK 525    HOH B1621        DISTANCE =  6.00 ANGSTROMS                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL A 1301                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1302                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1303                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1304                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1305                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A 1306                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 1203                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1204                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1205                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1206                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1207                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1208                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1209                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1210                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1211                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B 1212                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL F 602                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 3P8C   RELATED DB: PDB                                   
REMARK 900 APO COMPLEX                                                          
DBREF  4N78 A    1  1253  UNP    Q7L576   CYFP1_HUMAN      1   1253             
DBREF  4N78 B    1  1128  UNP    Q9Y2A7   NCKP1_HUMAN      1   1128             
DBREF  4N78 D    1   559  UNP    Q92558   WASF1_HUMAN      1    559             
DBREF  4N78 E    1    75  UNP    Q8WUW1   BRK1_HUMAN       1     75             
DBREF  4N78 F    1   513  UNP    J3KNB2   J3KNB2_HUMAN     1    513             
DBREF  4N78 P    1    15  PDB    4N78     4N78             1     15             
SEQADV 4N78 ALA F    0  UNP  J3KNB2              EXPRESSION TAG                 
SEQRES   1 A 1253  MET ALA ALA GLN VAL THR LEU GLU ASP ALA LEU SER ASN          
SEQRES   2 A 1253  VAL ASP LEU LEU GLU GLU LEU PRO LEU PRO ASP GLN GLN          
SEQRES   3 A 1253  PRO CYS ILE GLU PRO PRO PRO SER SER LEU LEU TYR GLN          
SEQRES   4 A 1253  PRO ASN PHE ASN THR ASN PHE GLU ASP ARG ASN ALA PHE          
SEQRES   5 A 1253  VAL THR GLY ILE ALA ARG TYR ILE GLU GLN ALA THR VAL          
SEQRES   6 A 1253  HIS SER SER MET ASN GLU MET LEU GLU GLU GLY GLN GLU          
SEQRES   7 A 1253  TYR ALA VAL MET LEU TYR THR TRP ARG SER CYS SER ARG          
SEQRES   8 A 1253  ALA ILE PRO GLN VAL LYS CYS ASN GLU GLN PRO ASN ARG          
SEQRES   9 A 1253  VAL GLU ILE TYR GLU LYS THR VAL GLU VAL LEU GLU PRO          
SEQRES  10 A 1253  GLU VAL THR LYS LEU MET ASN PHE MET TYR PHE GLN ARG          
SEQRES  11 A 1253  ASN ALA ILE GLU ARG PHE CYS GLY GLU VAL ARG ARG LEU          
SEQRES  12 A 1253  CYS HIS ALA GLU ARG ARG LYS ASP PHE VAL SER GLU ALA          
SEQRES  13 A 1253  TYR LEU ILE THR LEU GLY LYS PHE ILE ASN MET PHE ALA          
SEQRES  14 A 1253  VAL LEU ASP GLU LEU LYS ASN MET LYS CYS SER VAL LYS          
SEQRES  15 A 1253  ASN ASP HIS SER ALA TYR LYS ARG ALA ALA GLN PHE LEU          
SEQRES  16 A 1253  ARG LYS MET ALA ASP PRO GLN SER ILE GLN GLU SER GLN          
SEQRES  17 A 1253  ASN LEU SER MET PHE LEU ALA ASN HIS ASN LYS ILE THR          
SEQRES  18 A 1253  GLN SER LEU GLN GLN GLN LEU GLU VAL ILE SER GLY TYR          
SEQRES  19 A 1253  GLU GLU LEU LEU ALA ASP ILE VAL ASN LEU CYS VAL ASP          
SEQRES  20 A 1253  TYR TYR GLU ASN ARG MET TYR LEU THR PRO SER GLU LYS          
SEQRES  21 A 1253  HIS MET LEU LEU LYS VAL MET GLY PHE GLY LEU TYR LEU          
SEQRES  22 A 1253  MET ASP GLY SER VAL SER ASN ILE TYR LYS LEU ASP ALA          
SEQRES  23 A 1253  LYS LYS ARG ILE ASN LEU SER LYS ILE ASP LYS TYR PHE          
SEQRES  24 A 1253  LYS GLN LEU GLN VAL VAL PRO LEU PHE GLY ASP MET GLN          
SEQRES  25 A 1253  ILE GLU LEU ALA ARG TYR ILE LYS THR SER ALA HIS TYR          
SEQRES  26 A 1253  GLU GLU ASN LYS SER ARG TRP THR CYS THR SER SER GLY          
SEQRES  27 A 1253  SER SER PRO GLN TYR ASN ILE CYS GLU GLN MET ILE GLN          
SEQRES  28 A 1253  ILE ARG GLU ASP HIS MET ARG PHE ILE SER GLU LEU ALA          
SEQRES  29 A 1253  ARG TYR SER ASN SER GLU VAL VAL THR GLY SER GLY ARG          
SEQRES  30 A 1253  GLN GLU ALA GLN LYS THR ASP ALA GLU TYR ARG LYS LEU          
SEQRES  31 A 1253  PHE ASP LEU ALA LEU GLN GLY LEU GLN LEU LEU SER GLN          
SEQRES  32 A 1253  TRP SER ALA HIS VAL MET GLU VAL TYR SER TRP LYS LEU          
SEQRES  33 A 1253  VAL HIS PRO THR ASP LYS TYR SER ASN LYS ASP CYS PRO          
SEQRES  34 A 1253  ASP SER ALA GLU GLU TYR GLU ARG ALA THR ARG TYR ASN          
SEQRES  35 A 1253  TYR THR SER GLU GLU LYS PHE ALA LEU VAL GLU VAL ILE          
SEQRES  36 A 1253  ALA MET ILE LYS GLY LEU GLN VAL LEU MET GLY ARG MET          
SEQRES  37 A 1253  GLU SER VAL PHE ASN HIS ALA ILE ARG HIS THR VAL TYR          
SEQRES  38 A 1253  ALA ALA LEU GLN ASP PHE SER GLN VAL THR LEU ARG GLU          
SEQRES  39 A 1253  PRO LEU ARG GLN ALA ILE LYS LYS LYS LYS ASN VAL ILE          
SEQRES  40 A 1253  GLN SER VAL LEU GLN ALA ILE ARG LYS THR VAL CYS ASP          
SEQRES  41 A 1253  TRP GLU THR GLY HIS GLU PRO PHE ASN ASP PRO ALA LEU          
SEQRES  42 A 1253  ARG GLY GLU LYS ASP PRO LYS SER GLY PHE ASP ILE LYS          
SEQRES  43 A 1253  VAL PRO ARG ARG ALA VAL GLY PRO SER SER THR GLN LEU          
SEQRES  44 A 1253  TYR MET VAL ARG THR MET LEU GLU SER LEU ILE ALA ASP          
SEQRES  45 A 1253  LYS SER GLY SER LYS LYS THR LEU ARG SER SER LEU GLU          
SEQRES  46 A 1253  GLY PRO THR ILE LEU ASP ILE GLU LYS PHE HIS ARG GLU          
SEQRES  47 A 1253  SER PHE PHE TYR THR HIS LEU ILE ASN PHE SER GLU THR          
SEQRES  48 A 1253  LEU GLN GLN CYS CYS ASP LEU SER GLN LEU TRP PHE ARG          
SEQRES  49 A 1253  GLU PHE PHE LEU GLU LEU THR MET GLY ARG ARG ILE GLN          
SEQRES  50 A 1253  PHE PRO ILE GLU MET SER MET PRO TRP ILE LEU THR ASP          
SEQRES  51 A 1253  HIS ILE LEU GLU THR LYS GLU ALA SER MET MET GLU TYR          
SEQRES  52 A 1253  VAL LEU TYR SER LEU ASP LEU TYR ASN ASP SER ALA HIS          
SEQRES  53 A 1253  TYR ALA LEU THR ARG PHE ASN LYS GLN PHE LEU TYR ASP          
SEQRES  54 A 1253  GLU ILE GLU ALA GLU VAL ASN LEU CYS PHE ASP GLN PHE          
SEQRES  55 A 1253  VAL TYR LYS LEU ALA ASP GLN ILE PHE ALA TYR TYR LYS          
SEQRES  56 A 1253  VAL MET ALA GLY SER LEU LEU LEU ASP LYS ARG LEU ARG          
SEQRES  57 A 1253  SER GLU CYS LYS ASN GLN GLY ALA THR ILE HIS LEU PRO          
SEQRES  58 A 1253  PRO SER ASN ARG TYR GLU THR LEU LEU LYS GLN ARG HIS          
SEQRES  59 A 1253  VAL GLN LEU LEU GLY ARG SER ILE ASP LEU ASN ARG LEU          
SEQRES  60 A 1253  ILE THR GLN ARG VAL SER ALA ALA MET TYR LYS SER LEU          
SEQRES  61 A 1253  GLU LEU ALA ILE GLY ARG PHE GLU SER GLU ASP LEU THR          
SEQRES  62 A 1253  SER ILE VAL GLU LEU ASP GLY LEU LEU GLU ILE ASN ARG          
SEQRES  63 A 1253  MET THR HIS LYS LEU LEU SER ARG TYR LEU THR LEU ASP          
SEQRES  64 A 1253  GLY PHE ASP ALA MET PHE ARG GLU ALA ASN HIS ASN VAL          
SEQRES  65 A 1253  SER ALA PRO TYR GLY ARG ILE THR LEU HIS VAL PHE TRP          
SEQRES  66 A 1253  GLU LEU ASN TYR ASP PHE LEU PRO ASN TYR CYS TYR ASN          
SEQRES  67 A 1253  GLY SER THR ASN ARG PHE VAL ARG THR VAL LEU PRO PHE          
SEQRES  68 A 1253  SER GLN GLU PHE GLN ARG ASP LYS GLN PRO ASN ALA GLN          
SEQRES  69 A 1253  PRO GLN TYR LEU HIS GLY SER LYS ALA LEU ASN LEU ALA          
SEQRES  70 A 1253  TYR SER SER ILE TYR GLY SER TYR ARG ASN PHE VAL GLY          
SEQRES  71 A 1253  PRO PRO HIS PHE GLN VAL ILE CYS ARG LEU LEU GLY TYR          
SEQRES  72 A 1253  GLN GLY ILE ALA VAL VAL MET GLU GLU LEU LEU LYS VAL          
SEQRES  73 A 1253  VAL LYS SER LEU LEU GLN GLY THR ILE LEU GLN TYR VAL          
SEQRES  74 A 1253  LYS THR LEU MET GLU VAL MET PRO LYS ILE CYS ARG LEU          
SEQRES  75 A 1253  PRO ARG HIS GLU TYR GLY SER PRO GLY ILE LEU GLU PHE          
SEQRES  76 A 1253  PHE HIS HIS GLN LEU LYS ASP ILE VAL GLU TYR ALA GLU          
SEQRES  77 A 1253  LEU LYS THR VAL CYS PHE GLN ASN LEU ARG GLU VAL GLY          
SEQRES  78 A 1253  ASN ALA ILE LEU PHE CYS LEU LEU ILE GLU GLN SER LEU          
SEQRES  79 A 1253  SER LEU GLU GLU VAL CYS ASP LEU LEU HIS ALA ALA PRO          
SEQRES  80 A 1253  PHE GLN ASN ILE LEU PRO ARG VAL HIS VAL LYS GLU GLY          
SEQRES  81 A 1253  GLU ARG LEU ASP ALA LYS MET LYS ARG LEU GLU SER LYS          
SEQRES  82 A 1253  TYR ALA PRO LEU HIS LEU VAL PRO LEU ILE GLU ARG LEU          
SEQRES  83 A 1253  GLY THR PRO GLN GLN ILE ALA ILE ALA ARG GLU GLY ASP          
SEQRES  84 A 1253  LEU LEU THR LYS GLU ARG LEU CYS CYS GLY LEU SER MET          
SEQRES  85 A 1253  PHE GLU VAL ILE LEU THR ARG ILE ARG SER PHE LEU ASP          
SEQRES  86 A 1253  ASP PRO ILE TRP ARG GLY PRO LEU PRO SER ASN GLY VAL          
SEQRES  87 A 1253  MET HIS VAL ASP GLU CYS VAL GLU PHE HIS ARG LEU TRP          
SEQRES  88 A 1253  SER ALA MET GLN PHE VAL TYR CYS ILE PRO VAL GLY THR          
SEQRES  89 A 1253  HIS GLU PHE THR VAL GLU GLN CYS PHE GLY ASP GLY LEU          
SEQRES  90 A 1253  HIS TRP ALA GLY CYS MET ILE ILE VAL LEU LEU GLY GLN          
SEQRES  91 A 1253  GLN ARG ARG PHE ALA VAL LEU ASP PHE CYS TYR HIS LEU          
SEQRES  92 A 1253  LEU LYS VAL GLN LYS HIS ASP GLY LYS ASP GLU ILE ILE          
SEQRES  93 A 1253  LYS ASN VAL PRO LEU LYS LYS MET VAL GLU ARG ILE ARG          
SEQRES  94 A 1253  LYS PHE GLN ILE LEU ASN ASP GLU ILE ILE THR ILE LEU          
SEQRES  95 A 1253  ASP LYS TYR LEU LYS SER GLY ASP GLY GLU GLY THR PRO          
SEQRES  96 A 1253  VAL GLU HIS VAL ARG CYS PHE GLN PRO PRO ILE HIS GLN          
SEQRES  97 A 1253  SER LEU ALA SER SER                                          
SEQRES   1 B 1128  MET SER ARG SER VAL LEU GLN PRO SER GLN GLN LYS LEU          
SEQRES   2 B 1128  ALA GLU LYS LEU THR ILE LEU ASN ASP ARG GLY VAL GLY          
SEQRES   3 B 1128  MET LEU THR ARG LEU TYR ASN ILE LYS LYS ALA CYS GLY          
SEQRES   4 B 1128  ASP PRO LYS ALA LYS PRO SER TYR LEU ILE ASP LYS ASN          
SEQRES   5 B 1128  LEU GLU SER ALA VAL LYS PHE ILE VAL ARG LYS PHE PRO          
SEQRES   6 B 1128  ALA VAL GLU THR ARG ASN ASN ASN GLN GLN LEU ALA GLN          
SEQRES   7 B 1128  LEU GLN LYS GLU LYS SER GLU ILE LEU LYS ASN LEU ALA          
SEQRES   8 B 1128  LEU TYR TYR PHE THR PHE VAL ASP VAL MET GLU PHE LYS          
SEQRES   9 B 1128  ASP HIS VAL CYS GLU LEU LEU ASN THR ILE ASP VAL CYS          
SEQRES  10 B 1128  GLN VAL PHE PHE ASP ILE THR VAL ASN PHE ASP LEU THR          
SEQRES  11 B 1128  LYS ASN TYR LEU ASP LEU ILE ILE THR TYR THR THR LEU          
SEQRES  12 B 1128  MET ILE LEU LEU SER ARG ILE GLU GLU ARG LYS ALA ILE          
SEQRES  13 B 1128  ILE GLY LEU TYR ASN TYR ALA HIS GLU MET THR HIS GLY          
SEQRES  14 B 1128  ALA SER ASP ARG GLU TYR PRO ARG LEU GLY GLN MET ILE          
SEQRES  15 B 1128  VAL ASP TYR GLU ASN PRO LEU LYS LYS MET MET GLU GLU          
SEQRES  16 B 1128  PHE VAL PRO HIS SER LYS SER LEU SER ASP ALA LEU ILE          
SEQRES  17 B 1128  SER LEU GLN MET VAL TYR PRO ARG ARG ASN LEU SER ALA          
SEQRES  18 B 1128  ASP GLN TRP ARG ASN ALA GLN LEU LEU SER LEU ILE SER          
SEQRES  19 B 1128  ALA PRO SER THR MET LEU ASN PRO ALA GLN SER ASP THR          
SEQRES  20 B 1128  MET PRO CYS GLU TYR LEU SER LEU ASP ALA MET GLU LYS          
SEQRES  21 B 1128  TRP ILE ILE PHE GLY PHE ILE LEU CYS HIS GLY ILE LEU          
SEQRES  22 B 1128  ASN THR ASP ALA THR ALA LEU ASN LEU TRP LYS LEU ALA          
SEQRES  23 B 1128  LEU GLN SER SER SER CYS LEU SER LEU PHE ARG ASP GLU          
SEQRES  24 B 1128  VAL PHE HIS ILE HIS LYS ALA ALA GLU ASP LEU PHE VAL          
SEQRES  25 B 1128  ASN ILE ARG GLY TYR ASN LYS ARG ILE ASN ASP ILE ARG          
SEQRES  26 B 1128  GLU CYS LYS GLU ALA ALA VAL SER HIS ALA GLY SER MET          
SEQRES  27 B 1128  HIS ARG GLU ARG ARG LYS PHE LEU ARG SER ALA LEU LYS          
SEQRES  28 B 1128  GLU LEU ALA THR VAL LEU SER ASP GLN PRO GLY LEU LEU          
SEQRES  29 B 1128  GLY PRO LYS ALA LEU PHE VAL PHE MET ALA LEU SER PHE          
SEQRES  30 B 1128  ALA ARG ASP GLU ILE ILE TRP LEU LEU ARG HIS ALA ASP          
SEQRES  31 B 1128  ASN MET PRO LYS LYS SER ALA ASP ASP PHE ILE ASP LYS          
SEQRES  32 B 1128  HIS ILE ALA GLU LEU ILE PHE TYR MET GLU GLU LEU ARG          
SEQRES  33 B 1128  ALA HIS VAL ARG LYS TYR GLY PRO VAL MET GLN ARG TYR          
SEQRES  34 B 1128  TYR VAL GLN TYR LEU SER GLY PHE ASP ALA VAL VAL LEU          
SEQRES  35 B 1128  ASN GLU LEU VAL GLN ASN LEU SER VAL CYS PRO GLU ASP          
SEQRES  36 B 1128  GLU SER ILE ILE MET SER SER PHE VAL ASN THR MET THR          
SEQRES  37 B 1128  SER LEU SER VAL LYS GLN VAL GLU ASP GLY GLU VAL PHE          
SEQRES  38 B 1128  ASP PHE ARG GLY MET ARG LEU ASP TRP PHE ARG LEU GLN          
SEQRES  39 B 1128  ALA TYR THR SER VAL SER LYS ALA SER LEU GLY LEU ALA          
SEQRES  40 B 1128  ASP HIS ARG GLU LEU GLY LYS MET MET ASN THR ILE ILE          
SEQRES  41 B 1128  PHE HIS THR LYS MET VAL ASP SER LEU VAL GLU MET LEU          
SEQRES  42 B 1128  VAL GLU THR SER ASP LEU SER ILE PHE CYS PHE TYR SER          
SEQRES  43 B 1128  ARG ALA PHE GLU LYS MET PHE GLN GLN CYS LEU GLU LEU          
SEQRES  44 B 1128  PRO SER GLN SER ARG TYR SER ILE ALA PHE PRO LEU LEU          
SEQRES  45 B 1128  CYS THR HIS PHE MET SER CYS THR HIS GLU LEU CYS PRO          
SEQRES  46 B 1128  GLU GLU ARG HIS HIS ILE GLY ASP ARG SER LEU SER LEU          
SEQRES  47 B 1128  CYS ASN MET PHE LEU ASP GLU MET ALA LYS GLN ALA ARG          
SEQRES  48 B 1128  ASN LEU ILE THR ASP ILE CYS THR GLU GLN CYS THR LEU          
SEQRES  49 B 1128  SER ASP GLN LEU LEU PRO LYS HIS CYS ALA LYS THR ILE          
SEQRES  50 B 1128  SER GLN ALA VAL ASN LYS LYS SER LYS LYS GLN THR GLY          
SEQRES  51 B 1128  LYS LYS GLY GLU PRO GLU ARG GLU LYS PRO GLY VAL GLU          
SEQRES  52 B 1128  SER MET ARG LYS ASN ARG LEU VAL VAL THR ASN LEU ASP          
SEQRES  53 B 1128  LYS LEU HIS THR ALA LEU SER GLU LEU CYS PHE SER ILE          
SEQRES  54 B 1128  ASN TYR VAL PRO ASN MET VAL VAL TRP GLU HIS THR PHE          
SEQRES  55 B 1128  THR PRO ARG GLU TYR LEU THR SER HIS LEU GLU ILE ARG          
SEQRES  56 B 1128  PHE THR LYS SER ILE VAL GLY MET THR MET TYR ASN GLN          
SEQRES  57 B 1128  ALA THR GLN GLU ILE ALA LYS PRO SER GLU LEU LEU THR          
SEQRES  58 B 1128  SER VAL ARG ALA TYR MET THR VAL LEU GLN SER ILE GLU          
SEQRES  59 B 1128  ASN TYR VAL GLN ILE ASP ILE THR ARG VAL PHE ASN ASN          
SEQRES  60 B 1128  VAL LEU LEU GLN GLN THR GLN HIS LEU ASP SER HIS GLY          
SEQRES  61 B 1128  GLU PRO THR ILE THR SER LEU TYR THR ASN TRP TYR LEU          
SEQRES  62 B 1128  GLU THR LEU LEU ARG GLN VAL SER ASN GLY HIS ILE ALA          
SEQRES  63 B 1128  TYR PHE PRO ALA MET LYS ALA PHE VAL ASN LEU PRO THR          
SEQRES  64 B 1128  GLU ASN GLU LEU THR PHE ASN ALA GLU GLU TYR SER ASP          
SEQRES  65 B 1128  ILE SER GLU MET ARG SER LEU SER GLU LEU LEU GLY PRO          
SEQRES  66 B 1128  TYR GLY MET LYS PHE LEU SER GLU SER LEU MET TRP HIS          
SEQRES  67 B 1128  ILE SER SER GLN VAL ALA GLU LEU LYS LYS LEU VAL VAL          
SEQRES  68 B 1128  GLU ASN VAL ASP VAL LEU THR GLN MET ARG THR SER PHE          
SEQRES  69 B 1128  ASP LYS PRO ASP GLN MET ALA ALA LEU PHE LYS ARG LEU          
SEQRES  70 B 1128  SER SER VAL ASP SER VAL LEU LYS ARG MET THR ILE ILE          
SEQRES  71 B 1128  GLY VAL ILE LEU SER PHE ARG SER LEU ALA GLN GLU ALA          
SEQRES  72 B 1128  LEU ARG ASP VAL LEU SER TYR HIS ILE PRO PHE LEU VAL          
SEQRES  73 B 1128  SER SER ILE GLU ASP PHE LYS ASP HIS ILE PRO ARG GLU          
SEQRES  74 B 1128  THR ASP MET LYS VAL ALA MET ASN VAL TYR GLU LEU SER          
SEQRES  75 B 1128  SER ALA ALA GLY LEU PRO CYS GLU ILE ASP PRO ALA LEU          
SEQRES  76 B 1128  VAL VAL ALA LEU SER SER GLN LYS SER GLU ASN ILE SER          
SEQRES  77 B 1128  PRO GLU GLU GLU TYR LYS ILE ALA CYS LEU LEU MET VAL          
SEQRES  78 B 1128  PHE VAL ALA VAL SER LEU PRO THR LEU ALA SER ASN VAL          
SEQRES  79 B 1128  MET SER GLN TYR SER PRO ALA ILE GLU GLY HIS CYS ASN          
SEQRES  80 B 1128  ASN ILE HIS CYS LEU ALA LYS ALA ILE ASN GLN ILE ALA          
SEQRES  81 B 1128  ALA ALA LEU PHE THR ILE HIS LYS GLY SER ILE GLU ASP          
SEQRES  82 B 1128  ARG LEU LYS GLU PHE LEU ALA LEU ALA SER SER SER LEU          
SEQRES  83 B 1128  LEU LYS ILE GLY GLN GLU THR ASP LYS THR THR THR ARG          
SEQRES  84 B 1128  ASN ARG GLU SER VAL TYR LEU LEU LEU ASP MET ILE VAL          
SEQRES  85 B 1128  GLN GLU SER PRO PHE LEU THR MET ASP LEU LEU GLU SER          
SEQRES  86 B 1128  CYS PHE PRO TYR VAL LEU LEU ARG ASN ALA TYR HIS ALA          
SEQRES  87 B 1128  VAL TYR LYS GLN SER VAL THR SER SER ALA                      
SEQRES   1 D  559  MET PRO LEU VAL LYS ARG ASN ILE ASP PRO ARG HIS LEU          
SEQRES   2 D  559  CYS HIS THR ALA LEU PRO ARG GLY ILE LYS ASN GLU LEU          
SEQRES   3 D  559  GLU CYS VAL THR ASN ILE SER LEU ALA ASN ILE ILE ARG          
SEQRES   4 D  559  GLN LEU SER SER LEU SER LYS TYR ALA GLU ASP ILE PHE          
SEQRES   5 D  559  GLY GLU LEU PHE ASN GLU ALA HIS SER PHE SER PHE ARG          
SEQRES   6 D  559  VAL ASN SER LEU GLN GLU ARG VAL ASP ARG LEU SER VAL          
SEQRES   7 D  559  SER VAL THR GLN LEU ASP PRO LYS GLU GLU GLU LEU SER          
SEQRES   8 D  559  LEU GLN ASP ILE THR MET ARG LYS ALA PHE ARG SER SER          
SEQRES   9 D  559  THR ILE GLN ASP GLN GLN LEU PHE ASP ARG LYS THR LEU          
SEQRES  10 D  559  PRO ILE PRO LEU GLN GLU THR TYR ASP VAL CYS GLU GLN          
SEQRES  11 D  559  PRO PRO PRO LEU ASN ILE LEU THR PRO TYR ARG ASP ASP          
SEQRES  12 D  559  GLY LYS GLU GLY LEU LYS PHE TYR THR ASN PRO SER TYR          
SEQRES  13 D  559  PHE PHE ASP LEU TRP LYS GLU LYS MET LEU GLN ASP THR          
SEQRES  14 D  559  GLU ASP LYS ARG LYS GLU LYS ARG LYS GLN LYS GLN LYS          
SEQRES  15 D  559  ASN LEU ASP ARG PRO HIS GLU PRO GLU LYS VAL PRO ARG          
SEQRES  16 D  559  ALA PRO HIS ASP ARG ARG ARG GLU TRP GLN LYS LEU ALA          
SEQRES  17 D  559  GLN GLY PRO GLU LEU ALA GLU ASP ASP ALA ASN LEU LEU          
SEQRES  18 D  559  HIS LYS HIS ILE GLU VAL ALA ASN GLY PRO ALA SER HIS          
SEQRES  19 D  559  PHE GLU THR ARG PRO GLN THR TYR VAL ASP HIS MET ASP          
SEQRES  20 D  559  GLY SER TYR SER LEU SER ALA LEU PRO PHE SER GLN MET          
SEQRES  21 D  559  SER GLU LEU LEU THR ARG ALA GLU GLU ARG VAL LEU VAL          
SEQRES  22 D  559  ARG PRO HIS GLU PRO PRO PRO PRO PRO PRO MET HIS GLY          
SEQRES  23 D  559  ALA GLY ASP ALA LYS PRO ILE PRO THR CYS ILE SER SER          
SEQRES  24 D  559  ALA THR GLY LEU ILE GLU ASN ARG PRO GLN SER PRO ALA          
SEQRES  25 D  559  THR GLY ARG THR PRO VAL PHE VAL SER PRO THR PRO PRO          
SEQRES  26 D  559  PRO PRO PRO PRO PRO LEU PRO SER ALA LEU SER THR SER          
SEQRES  27 D  559  SER LEU ARG ALA SER MET THR SER THR PRO PRO PRO PRO          
SEQRES  28 D  559  VAL PRO PRO PRO PRO PRO PRO PRO ALA THR ALA LEU GLN          
SEQRES  29 D  559  ALA PRO ALA VAL PRO PRO PRO PRO ALA PRO LEU GLN ILE          
SEQRES  30 D  559  ALA PRO GLY VAL LEU HIS PRO ALA PRO PRO PRO ILE ALA          
SEQRES  31 D  559  PRO PRO LEU VAL GLN PRO SER PRO PRO VAL ALA ARG ALA          
SEQRES  32 D  559  ALA PRO VAL CYS GLU THR VAL PRO VAL HIS PRO LEU PRO          
SEQRES  33 D  559  GLN GLY GLU VAL GLN GLY LEU PRO PRO PRO PRO PRO PRO          
SEQRES  34 D  559  PRO PRO LEU PRO PRO PRO GLY ILE ARG PRO SER SER PRO          
SEQRES  35 D  559  VAL THR VAL THR ALA LEU ALA HIS PRO PRO SER GLY LEU          
SEQRES  36 D  559  HIS PRO THR PRO SER THR ALA PRO GLY PRO HIS VAL PRO          
SEQRES  37 D  559  LEU MET PRO PRO SER PRO PRO SER GLN VAL ILE PRO ALA          
SEQRES  38 D  559  SER GLU PRO LYS ARG HIS PRO SER THR LEU PRO VAL ILE          
SEQRES  39 D  559  SER ASP ALA ARG SER VAL LEU LEU GLU ALA ILE ARG LYS          
SEQRES  40 D  559  GLY ILE GLN LEU ARG LYS VAL GLU GLU GLN ARG GLU GLN          
SEQRES  41 D  559  GLU ALA LYS HIS GLU ARG ILE GLU ASN ASP VAL ALA THR          
SEQRES  42 D  559  ILE LEU SER ARG ARG ILE ALA VAL GLU TYR SER ASP SER          
SEQRES  43 D  559  GLU ASP ASP SER GLU PHE ASP GLU VAL ASP TRP LEU GLU          
SEQRES   1 E   75  MET ALA GLY GLN GLU ASP PRO VAL GLN ARG GLU ILE HIS          
SEQRES   2 E   75  GLN ASP TRP ALA ASN ARG GLU TYR ILE GLU ILE ILE THR          
SEQRES   3 E   75  SER SER ILE LYS LYS ILE ALA ASP PHE LEU ASN SER PHE          
SEQRES   4 E   75  ASP MET SER CYS ARG SER ARG LEU ALA THR LEU ASN GLU          
SEQRES   5 E   75  LYS LEU THR ALA LEU GLU ARG ARG ILE GLU TYR ILE GLU          
SEQRES   6 E   75  ALA ARG VAL THR LYS GLY GLU THR LEU THR                      
SEQRES   1 F  514  ALA MET ALA GLU LEU GLN MET LEU LEU GLU GLU GLU ILE          
SEQRES   2 F  514  PRO GLY GLY ARG ARG ALA LEU PHE ASP SER TYR THR ASN          
SEQRES   3 F  514  LEU GLU ARG VAL ALA ASP TYR CYS GLU ASN ASN TYR ILE          
SEQRES   4 F  514  GLN SER ALA ASP LYS GLN ARG ALA LEU GLU GLU THR LYS          
SEQRES   5 F  514  ALA TYR THR THR GLN SER LEU ALA SER VAL ALA TYR LEU          
SEQRES   6 F  514  ILE ASN THR LEU ALA ASN ASN VAL LEU GLN MET LEU ASP          
SEQRES   7 F  514  ILE GLN ALA SER GLN LEU ARG ARG MET GLU SER SER ILE          
SEQRES   8 F  514  ASN HIS ILE SER GLN THR VAL ASP ILE HIS LYS GLU LYS          
SEQRES   9 F  514  VAL ALA ARG ARG GLU ILE GLY ILE LEU THR THR ASN LYS          
SEQRES  10 F  514  ASN THR SER ARG THR HIS LYS ILE ILE ALA PRO ALA ASN          
SEQRES  11 F  514  LEU GLU ARG PRO VAL ARG TYR ILE ARG LYS PRO ILE ASP          
SEQRES  12 F  514  TYR THR ILE LEU ASP ASP ILE GLY HIS GLY VAL LYS TRP          
SEQRES  13 F  514  LEU LEU ARG PHE LYS VAL SER THR GLN ASN MET LYS MET          
SEQRES  14 F  514  GLY GLY LEU PRO ARG THR THR PRO PRO THR GLN LYS PRO          
SEQRES  15 F  514  PRO SER PRO PRO MET SER GLY LYS GLY THR LEU GLY ARG          
SEQRES  16 F  514  HIS SER PRO TYR ARG THR LEU GLU PRO VAL ARG PRO PRO          
SEQRES  17 F  514  VAL VAL PRO ASN ASP TYR VAL PRO SER PRO THR ARG ASN          
SEQRES  18 F  514  MET ALA PRO SER GLN GLN SER PRO VAL ARG THR ALA SER          
SEQRES  19 F  514  VAL ASN GLN ARG ASN ARG THR TYR SER SER SER GLY SER          
SEQRES  20 F  514  SER GLY GLY SER HIS PRO SER SER ARG SER SER SER ARG          
SEQRES  21 F  514  GLU ASN SER GLY SER GLY SER VAL GLY VAL PRO ILE ALA          
SEQRES  22 F  514  VAL PRO THR PRO SER PRO PRO SER VAL PHE PRO ALA PRO          
SEQRES  23 F  514  ALA GLY SER ALA GLY THR PRO PRO LEU PRO ALA THR SER          
SEQRES  24 F  514  ALA SER ALA PRO ALA PRO LEU VAL PRO ALA THR VAL PRO          
SEQRES  25 F  514  SER SER THR ALA PRO ASP ALA ALA ALA GLY GLY ALA GLN          
SEQRES  26 F  514  THR LEU ALA ASP GLY PHE THR SER PRO THR PRO PRO VAL          
SEQRES  27 F  514  VAL SER SER THR PRO PRO THR GLY HIS PRO VAL GLN PHE          
SEQRES  28 F  514  TYR SER MET ASN ARG PRO ALA SER ARG HIS THR PRO PRO          
SEQRES  29 F  514  THR ILE GLY GLY SER LEU PRO TYR ARG ARG PRO PRO SER          
SEQRES  30 F  514  ILE THR SER GLN THR SER LEU GLN ASN GLN MET ASN GLY          
SEQRES  31 F  514  GLY PRO PHE TYR SER GLN ASN PRO VAL SER ASP THR PRO          
SEQRES  32 F  514  PRO PRO PRO PRO PRO VAL GLU GLU PRO VAL PHE ASP GLU          
SEQRES  33 F  514  SER PRO PRO PRO PRO PRO PRO PRO GLU ASP TYR GLU GLU          
SEQRES  34 F  514  GLU GLU ALA ALA VAL VAL GLU TYR SER ASP PRO TYR ALA          
SEQRES  35 F  514  GLU GLU ASP PRO PRO TRP ALA PRO ARG SER TYR LEU GLU          
SEQRES  36 F  514  LYS VAL VAL ALA ILE TYR ASP TYR THR LYS ASP LYS GLU          
SEQRES  37 F  514  ASP GLU LEU SER PHE GLN GLU GLY ALA ILE ILE TYR VAL          
SEQRES  38 F  514  ILE LYS LYS ASN ASP ASP GLY TRP TYR GLU GLY VAL MET          
SEQRES  39 F  514  ASN GLY VAL THR GLY LEU PHE PRO GLY ASN TYR VAL GLU          
SEQRES  40 F  514  SER ILE MET HIS TYR SER GLU                                  
SEQRES   1 P   15  TRP GLY ALA GLU ARG SER MET SER THR PHE GLY LYS GLU          
SEQRES   2 P   15  LYS ALA                                                      
HET     CL  A1301       1                                                       
HET    GOL  A1302       6                                                       
HET    GOL  A1303       6                                                       
HET    GOL  A1304       6                                                       
HET    GOL  A1305       6                                                       
HET    GOL  A1306       6                                                       
HET     CL  B1201       1                                                       
HET     CL  B1202       1                                                       
HET     CL  B1203       1                                                       
HET    GOL  B1204       6                                                       
HET    GOL  B1205       6                                                       
HET    GOL  B1206       6                                                       
HET    GOL  B1207       6                                                       
HET    GOL  B1208       6                                                       
HET    GOL  B1209       6                                                       
HET    GOL  B1210       6                                                       
HET    GOL  B1211       6                                                       
HET    GOL  B1212       6                                                       
HET    GOL  F 601       6                                                       
HET    GOL  F 602       6                                                       
HETNAM      CL CHLORIDE ION                                                     
HETNAM     GOL GLYCEROL                                                         
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL                                    
FORMUL   7   CL    4(CL 1-)                                                     
FORMUL   8  GOL    16(C3 H8 O3)                                                 
FORMUL  27  HOH   *746(H2 O)                                                    
HELIX    1   1 THR A    6  GLU A   19  1                                  14    
HELIX    2   2 ILE A   56  THR A   85  1                                  30    
HELIX    3   3 CYS A   89  ILE A   93  5                                   5    
HELIX    4   4 ASN A  103  CYS A  144  1                                  42    
HELIX    5   5 GLU A  147  ASP A  151  5                                   5    
HELIX    6   6 SER A  154  LYS A  178  1                                  25    
HELIX    7   7 LYS A  178  LEU A  195  1                                  18    
HELIX    8   8 ASP A  200  ASN A  216  1                                  17    
HELIX    9   9 ASN A  218  VAL A  230  1                                  13    
HELIX   10  10 GLY A  233  ARG A  252  1                                  20    
HELIX   11  11 THR A  256  MET A  274  1                                  19    
HELIX   12  12 ASN A  280  LYS A  287  1                                   8    
HELIX   13  13 ASN A  291  LEU A  302  1                                  12    
HELIX   14  14 LEU A  315  THR A  321  1                                   7    
HELIX   15  15 TYR A  325  TRP A  332  5                                   8    
HELIX   16  16 ASN A  344  ARG A  365  1                                  22    
HELIX   17  17 THR A  383  HIS A  418  1                                  36    
HELIX   18  18 GLU A  433  THR A  439  1                                   7    
HELIX   19  19 ARG A  440  TYR A  443  5                                   4    
HELIX   20  20 THR A  444  MET A  468  1                                  25    
HELIX   21  21 MET A  468  VAL A  490  1                                  23    
HELIX   22  22 LEU A  492  LYS A  502  1                                  11    
HELIX   23  23 LYS A  504  CYS A  519  1                                  16    
HELIX   24  24 SER A  555  ILE A  570  1                                  16    
HELIX   25  25 THR A  579  LEU A  584  5                                   6    
HELIX   26  26 GLU A  585  SER A  599  1                                  15    
HELIX   27  27 PHE A  601  ASN A  607  1                                   7    
HELIX   28  28 ASN A  607  CYS A  615  1                                   9    
HELIX   29  29 LEU A  618  TRP A  622  5                                   5    
HELIX   30  30 ARG A  624  THR A  631  1                                   8    
HELIX   31  31 PRO A  639  MET A  642  5                                   4    
HELIX   32  32 SER A  643  LYS A  656  1                                  14    
HELIX   33  33 GLU A  657  MET A  661  5                                   5    
HELIX   34  34 TYR A  663  ASP A  669  1                                   7    
HELIX   35  35 ASP A  669  ARG A  681  1                                  13    
HELIX   36  36 LYS A  684  LEU A  723  1                                  40    
HELIX   37  37 ASP A  724  ASN A  733  1                                  10    
HELIX   38  38 TYR A  746  LYS A  751  1                                   6    
HELIX   39  39 ASP A  763  GLU A  788  1                                  26    
HELIX   40  40 SER A  789  GLU A  790  5                                   2    
HELIX   41  41 ASP A  791  THR A  793  5                                   3    
HELIX   42  42 SER A  794  SER A  813  1                                  20    
HELIX   43  43 GLY A  820  ASN A  829  1                                  10    
HELIX   44  44 GLY A  837  ASP A  850  1                                  14    
HELIX   45  45 ASP A  850  ASN A  854  1                                   5    
HELIX   46  46 VAL A  868  SER A  872  5                                   5    
HELIX   47  47 GLN A  884  LEU A  888  5                                   5    
HELIX   48  48 SER A  891  TYR A  902  1                                  12    
HELIX   49  49 GLY A  903  ARG A  906  5                                   4    
HELIX   50  50 GLY A  910  GLN A  942  1                                  33    
HELIX   51  51 GLY A  943  MET A  956  1                                  14    
HELIX   52  52 ARG A  964  TYR A  967  5                                   4    
HELIX   53  53 GLY A  968  LEU A  980  1                                  13    
HELIX   54  54 LEU A  980  GLU A  985  1                                   6    
HELIX   55  55 VAL A  992  ALA A 1026  1                                  35    
HELIX   56  56 PRO A 1027  ASN A 1030  5                                   4    
HELIX   57  57 ARG A 1042  TYR A 1054  1                                  13    
HELIX   58  58 ALA A 1055  LEU A 1057  5                                   3    
HELIX   59  59 HIS A 1058  GLY A 1067  1                                  10    
HELIX   60  60 THR A 1068  GLU A 1084  1                                  17    
HELIX   61  61 ARG A 1085  CYS A 1088  5                                   4    
HELIX   62  62 MET A 1092  SER A 1102  1                                  11    
HELIX   63  63 GLU A 1126  ILE A 1140  1                                  15    
HELIX   64  64 THR A 1148  GLY A 1154  1                                   7    
HELIX   65  65 ASP A 1155  LEU A 1168  1                                  14    
HELIX   66  66 GLN A 1170  ASP A 1178  1                                   9    
HELIX   67  67 ASP A 1178  GLY A 1191  1                                  14    
HELIX   68  68 LEU A 1201  LYS A 1227  1                                  27    
HELIX   69  69 GLN B    7  GLN B   11  5                                   5    
HELIX   70  70 LYS B   12  GLY B   39  1                                  28    
HELIX   71  71 PRO B   45  ILE B   49  5                                   5    
HELIX   72  72 ASP B   50  PHE B   64  1                                  15    
HELIX   73  73 GLN B   78  LYS B   81  5                                   4    
HELIX   74  74 GLU B   82  GLN B  118  1                                  37    
HELIX   75  75 ASN B  126  ARG B  149  1                                  24    
HELIX   76  76 GLU B  152  MET B  166  1                                  15    
HELIX   77  77 GLU B  174  TYR B  185  1                                  12    
HELIX   78  78 ASN B  187  PHE B  196  1                                  10    
HELIX   79  79 HIS B  199  LEU B  210  1                                  12    
HELIX   80  80 VAL B  213  ASN B  218  1                                   6    
HELIX   81  81 SER B  220  ALA B  227  1                                   8    
HELIX   82  82 ALA B  235  MET B  239  5                                   5    
HELIX   83  83 THR B  247  LEU B  253  1                                   7    
HELIX   84  84 SER B  254  CYS B  269  1                                  16    
HELIX   85  85 HIS B  270  ASN B  274  5                                   5    
HELIX   86  86 ASP B  276  GLN B  288  1                                  13    
HELIX   87  87 ILE B  303  VAL B  312  1                                  10    
HELIX   88  88 TYR B  317  GLN B  360  1                                  44    
HELIX   89  89 PRO B  361  GLY B  365  5                                   5    
HELIX   90  90 LYS B  367  MET B  392  1                                  26    
HELIX   91  91 HIS B  404  TYR B  422  1                                  19    
HELIX   92  92 TYR B  422  GLY B  436  1                                  15    
HELIX   93  93 GLY B  436  ASN B  448  1                                  13    
HELIX   94  94 PRO B  453  SER B  469  1                                  17    
HELIX   95  95 SER B  471  ASP B  477  1                                   7    
HELIX   96  96 PHE B  483  VAL B  499  1                                  17    
HELIX   97  97 GLY B  505  ASP B  508  5                                   4    
HELIX   98  98 HIS B  509  SER B  528  1                                  20    
HELIX   99  99 SER B  528  ASP B  538  1                                  11    
HELIX  100 100 LEU B  539  PHE B  544  5                                   6    
HELIX  101 101 TYR B  545  LEU B  559  1                                  15    
HELIX  102 102 LEU B  559  ARG B  564  1                                   6    
HELIX  103 103 ILE B  567  CYS B  573  1                                   7    
HELIX  104 104 THR B  574  THR B  580  5                                   7    
HELIX  105 105 GLU B  587  GLN B  627  1                                  41    
HELIX  106 106 LEU B  628  HIS B  632  5                                   5    
HELIX  107 107 CYS B  633  ASN B  642  1                                  10    
HELIX  108 108 GLY B  661  MET B  665  5                                   5    
HELIX  109 109 THR B  673  ASN B  690  1                                  18    
HELIX  110 110 THR B  703  THR B  724  1                                  22    
HELIX  111 111 LYS B  735  ILE B  753  1                                  19    
HELIX  112 112 GLU B  754  TYR B  756  5                                   3    
HELIX  113 113 ASP B  760  GLN B  772  1                                  13    
HELIX  114 114 THR B  783  THR B  795  1                                  13    
HELIX  115 115 THR B  795  ASN B  802  1                                   8    
HELIX  116 116 ALA B  827  ASP B  832  1                                   6    
HELIX  117 117 ASP B  832  GLU B  872  1                                  41    
HELIX  118 118 ASN B  873  SER B  883  1                                  11    
HELIX  119 119 LYS B  886  LYS B  895  1                                  10    
HELIX  120 120 SER B  899  ILE B  932  1                                  34    
HELIX  121 121 ILE B  932  HIS B  945  1                                  14    
HELIX  122 122 MET B  952  ALA B  965  1                                  14    
HELIX  123 123 ASP B  972  SER B  981  1                                  10    
HELIX  124 124 PRO B  989  VAL B 1005  1                                  17    
HELIX  125 125 SER B 1006  SER B 1016  5                                  11    
HELIX  126 126 ASN B 1028  HIS B 1030  5                                   3    
HELIX  127 127 CYS B 1031  HIS B 1047  1                                  17    
HELIX  128 128 SER B 1050  ILE B 1069  1                                  20    
HELIX  129 129 GLY B 1070  GLU B 1072  5                                   3    
HELIX  130 130 ASN B 1080  SER B 1095  1                                  16    
HELIX  131 131 THR B 1099  SER B 1105  1                                   7    
HELIX  132 132 PRO B 1108  LYS B 1121  1                                  14    
HELIX  133 133 ASN D   24  LEU D   83  1                                  60    
HELIX  134 134 SER D   91  ILE D   95  5                                   5    
HELIX  135 135 ASP D  113  LEU D  117  5                                   5    
HELIX  136 136 PRO D  118  VAL D  127  1                                  10    
HELIX  137 137 PRO D  133  ARG D  141  5                                   9    
HELIX  138 138 GLU D  146  TYR D  151  5                                   6    
HELIX  139 139 SER D  155  ARG D  177  1                                  23    
HELIX  140 140 SER D  499  GLN D  510  1                                  12    
HELIX  141 141 ASP D  530  VAL D  541  1                                  12    
HELIX  142 142 PRO E    7  THR E   69  1                                  63    
HELIX  143 143 MET F    1  GLU F   10  1                                  10    
HELIX  144 144 GLU F   10  GLN F   39  1                                  30    
HELIX  145 145 ASP F   42  ILE F  111  1                                  70    
HELIX  146 146 MET P    7  GLY P   11  5                                   5    
SHEET    1   A 2 VAL A 304  PHE A 308  0                                        
SHEET    2   A 2 MET A 311  GLU A 314 -1  O  ILE A 313   N  VAL A 305           
SHEET    1   B 2 VAL A 755  LEU A 757  0                                        
SHEET    2   B 2 ARG A 760  ILE A 762 -1  O  ILE A 762   N  VAL A 755           
SHEET    1   C 2 TYR A 855  ASN A 858  0                                        
SHEET    2   C 2 ARG A 863  ARG A 866 -1  O  VAL A 865   N  CYS A 856           
SHEET    1   D 2 LEU A1090  SER A1091  0                                        
SHEET    2   D 2 THR F 114  ASN F 115 -1  O  THR F 114   N  SER A1091           
SHEET    1   E 2 ILE A1195  ILE A1196  0                                        
SHEET    2   E 2 VAL A1199  PRO A1200 -1  O  VAL A1199   N  ILE A1196           
SHEET    1   F 2 CYS B 292  PHE B 296  0                                        
SHEET    2   F 2 GLU B 299  HIS B 302 -1  O  PHE B 301   N  LEU B 293           
SHEET    1   G 3 MET B 695  VAL B 697  0                                        
SHEET    2   G 3 HIS B 700  PHE B 702 -1  O  PHE B 702   N  MET B 695           
SHEET    3   G 3 ILE F 124  ILE F 125 -1  O  ILE F 125   N  THR B 701           
SHEET    1   H 2 ILE B 805  PHE B 808  0                                        
SHEET    2   H 2 ALA B 813  ASN B 816 -1  O  ALA B 813   N  PHE B 808           
SHEET    1   I 2 TYR B1018  SER B1019  0                                        
SHEET    2   I 2 GLY B1024  HIS B1025 -1  O  GLY B1024   N  SER B1019           
CISPEP   1 PHE B   64    PRO B   65          0        -0.06                     
SITE     1 AC1  1 HOH A1589                                                     
SITE     1 AC2  6 LYS A 656  ALA A 658  PRO A 742  SER A 743                    
SITE     2 AC2  6 ASN A 744  HOH A1549                                          
SITE     1 AC3  5 GLN A1187  LYS A1188  LYS A1202  ARG A1209                    
SITE     2 AC3  5 HOH A1617                                                     
SITE     1 AC4  5 GLN A  77  PHE A 308  GLY A 309  GLN A 620                    
SITE     2 AC4  5 TYR A 677                                                     
SITE     1 AC5  2 TYR A  79  LYS A 121                                          
SITE     1 AC6  8 THR A 769  THR A 817  HOH A1449  HOH A1494                    
SITE     2 AC6  8 HOH A1559  HOH A1600  HOH A1628  ARG E  59                    
SITE     1 AC7  4 ARG B 715  LYS B 718  GOL B1208  HOH B1435                    
SITE     1 AC8  4 ARG B 340  ARG B 343  PHE B 400  HOH B1335                    
SITE     1 AC9  1 ASP B 926                                                     
SITE     1 BC1  4 ARG B 744  SER B 834  ARG B 837  GLU B 841                    
SITE     1 BC2  6 PHE B 481  ASP B 482  ARG B 484  ASP B 527                    
SITE     2 BC2  6 SER B 528  GLU B 531                                          
SITE     1 BC3  5 LEU B 793  GLU B 794  ARG B 798  SER B 801                    
SITE     2 BC3  5 HIS B 858                                                     
SITE     1 BC4  4 ASP B 901  LEU B1010  ASN B1013  ASN B1027                    
SITE     1 BC5  3 LYS B 608  ARG B 611   CL B1201                               
SITE     1 BC6 10 GLU A  61  THR A  64  VAL A  65  SER A  68                    
SITE     2 BC6 10 VAL B 451  SER B 503  LEU B 504  GLY B 505                    
SITE     3 BC6 10 ASP B 508  HIS B 509                                          
SITE     1 BC7  4 GLN B 921  CYS B 969  ASP B 972  HOH B1327                    
SITE     1 BC8  4 ARG B 420  MET B 695  VAL B 696  HOH B1490                    
SITE     1 BC9  6 ARG B  30  ASN B  33  ILE B  34  LEU B  92                    
SITE     2 BC9  6 CYS B 584  GLU B 586                                          
SITE     1 CC1  2 HIS F 122  LYS F 123                                          
SITE     1 CC2  7 GLU B 582  LEU B 583  GLN D  82  ARG F 135                    
SITE     2 CC2  7 TYR F 136  ILE F 137  LYS F 139                               
CRYST1   97.492  114.750  323.605  90.00  90.00  90.00 P 21 21 21    4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010257  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.008715  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003090        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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