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Database: PDB
Entry: 5DO7
LinkDB: 5DO7
Original site: 5DO7 
HEADER    TRANSPORT PROTEIN                       10-SEP-15   5DO7              
TITLE     CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5;                
COMPND   3 CHAIN: A, C;                                                         
COMPND   4 SYNONYM: STEROLIN-1;                                                 
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MUTATION: YES;                                                       
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8;                
COMPND   9 CHAIN: B, D;                                                         
COMPND  10 SYNONYM: STEROLIN-2;                                                 
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ABCG5;                                                         
SOURCE   6 EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS;                            
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 4922;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: ABCG8;                                                         
SOURCE  13 EXPRESSION_SYSTEM: KOMAGATAELLA PASTORIS;                            
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 4922                                        
KEYWDS    ATP-BINDING CASSETTE TRANSPORTER, ABCG, STEROL EFFLUX,                
KEYWDS   2 SITOSTEROLEMIA, TRANSPORT PROTEIN                                    
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.-Y.LEE,L.N.KINCH,D.M.BOREK,I.L.URBATSCH,X.-S.XIE,N.V.GRISHIN,       
AUTHOR   2 J.C.COHEN,Z.OTWINOWSKI,H.H.HOBBS,D.M.ROSENBAUM                       
REVDAT   5   04-DEC-19 5DO7    1       REMARK                                   
REVDAT   4   27-SEP-17 5DO7    1       JRNL   REMARK                            
REVDAT   3   08-JUN-16 5DO7    1       JRNL                                     
REVDAT   2   25-MAY-16 5DO7    1       JRNL                                     
REVDAT   1   11-MAY-16 5DO7    0                                                
JRNL        AUTH   J.Y.LEE,L.N.KINCH,D.M.BOREK,J.WANG,J.WANG,I.L.URBATSCH,      
JRNL        AUTH 2 X.S.XIE,N.V.GRISHIN,J.C.COHEN,Z.OTWINOWSKI,H.H.HOBBS,        
JRNL        AUTH 3 D.M.ROSENBAUM                                                
JRNL        TITL   CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER            
JRNL        TITL 2 ABCG5/ABCG8.                                                 
JRNL        REF    NATURE                        V. 533   561 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   27144356                                                     
JRNL        DOI    10.1038/NATURE17666                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.93 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0049                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,              
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN                             
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD WITH PHASES                
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.93                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 25.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 82.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 34889                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.250                           
REMARK   3   R VALUE            (WORKING SET) : 0.245                           
REMARK   3   FREE R VALUE                     : 0.329                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1845                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.93                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 4.03                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 268                          
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 8.91                         
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3790                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 15                           
REMARK   3   BIN FREE R VALUE                    : 0.5710                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 18150                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 0                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 70.20                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 1.55000                                              
REMARK   3    B22 (A**2) : -3.40000                                             
REMARK   3    B33 (A**2) : 1.86000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 1.011         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.853         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 65.732        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.851                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.731                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 18543 ; 0.010 ; 0.019       
REMARK   3   BOND LENGTHS OTHERS               (A): 18216 ; 0.004 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 25094 ; 1.642 ; 1.970       
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 41693 ; 1.178 ; 3.000       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  2283 ; 8.986 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   776 ;33.839 ;22.668       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  3223 ;19.664 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   137 ;16.841 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  2881 ; 0.092 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 20659 ; 0.008 ; 0.021       
REMARK   3   GENERAL PLANES OTHERS             (A):  4458 ; 0.003 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  9174 ;28.686 ; 6.227       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  9173 ;28.667 ; 6.226       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 11443 ;42.062 ; 9.209       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2): 11444 ;42.061 ; 9.210       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  9369 ;33.893 ; 7.618       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  9370 ;33.891 ; 7.618       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2): 13652 ;48.153 ;10.747       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 78465 ;56.377 ;59.106       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 78466 ;56.377 ;59.107       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NCS TYPE: LOCAL                                                    
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  : 2                                 
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT    
REMARK   3    1     A    36    649       C    36    649   32507  0.16  0.05     
REMARK   3    2     B    24    669       D    24    669   29570  0.18  0.05     
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : MASK                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: SAD WITH TUNGSTATE FOR INITIAL PHASE      
REMARK   3  DETERMINATION. HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS    
REMARK   4                                                                      
REMARK   4 5DO7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-SEP-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000213485.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 26-NOV-13; 18-OCT-13               
REMARK 200  TEMPERATURE           (KELVIN) : 80; 80                             
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : NULL                               
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y; Y                               
REMARK 200  RADIATION SOURCE               : APS; APS                           
REMARK 200  BEAMLINE                       : 19-ID; 23-ID-D                     
REMARK 200  X-RAY GENERATOR MODEL          : NULL; NULL                         
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M; M                               
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0; 1.0                           
REMARK 200  MONOCHROMATOR                  : NULL; NULL                         
REMARK 200  OPTICS                         : NULL; NULL                         
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD; CCD                           
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R; MARMOSAIC 300   
REMARK 200                                   MM CCD                             
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-3000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-3000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 46342                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4                               
REMARK 200  DATA REDUNDANCY                : 18.90                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 8.8000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH; SINGLE WAVELENGTH           
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD                          
REMARK 200 SOFTWARE USED: MLPHARE                                               
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 69.83                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.08                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: BICELLE, AMMONIUM SULFATE, PEG 400,      
REMARK 280  MES, TCEP, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K          
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: I 2 2 2                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z                                                 
REMARK 290       3555   -X,Y,-Z                                                 
REMARK 290       4555   X,-Y,-Z                                                 
REMARK 290       5555   X+1/2,Y+1/2,Z+1/2                                       
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2                                     
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       8555   X+1/2,-Y+1/2,-Z+1/2                                     
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       86.77600            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      112.40200            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000      126.65200            
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       86.77600            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      112.40200            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000      126.65200            
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       86.77600            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      112.40200            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000      126.65200            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       86.77600            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      112.40200            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      126.65200            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5070 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 49250 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -28.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5120 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 48390 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -32.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, C                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     ASP A     3                                                      
REMARK 465     LEU A     4                                                      
REMARK 465     SER A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     LEU A     7                                                      
REMARK 465     THR A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     GLY A    11                                                      
REMARK 465     SER A    12                                                      
REMARK 465     MET A    13                                                      
REMARK 465     GLY A    14                                                      
REMARK 465     LEU A    15                                                      
REMARK 465     GLN A    16                                                      
REMARK 465     VAL A    17                                                      
REMARK 465     ASN A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     GLY A    20                                                      
REMARK 465     SER A    21                                                      
REMARK 465     GLN A    22                                                      
REMARK 465     SER A    23                                                      
REMARK 465     SER A    24                                                      
REMARK 465     LEU A    25                                                      
REMARK 465     GLU A    26                                                      
REMARK 465     GLY A    27                                                      
REMARK 465     ALA A    28                                                      
REMARK 465     PRO A    29                                                      
REMARK 465     ALA A    30                                                      
REMARK 465     THR A    31                                                      
REMARK 465     ALA A    32                                                      
REMARK 465     PRO A    33                                                      
REMARK 465     VAL A    47                                                      
REMARK 465     SER A    48                                                      
REMARK 465     HIS A    49                                                      
REMARK 465     ARG A    50                                                      
REMARK 465     VAL A    51                                                      
REMARK 465     ARG A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     TRP A    54                                                      
REMARK 465     TRP A    55                                                      
REMARK 465     ASP A    56                                                      
REMARK 465     ILE A    57                                                      
REMARK 465     THR A    58                                                      
REMARK 465     SER A    59                                                      
REMARK 465     CYS A    60                                                      
REMARK 465     ARG A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLN A    63                                                      
REMARK 465     TRP A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     GLY A   588                                                      
REMARK 465     SER A   589                                                      
REMARK 465     SER A   590                                                      
REMARK 465     ASN A   591                                                      
REMARK 465     VAL A   592                                                      
REMARK 465     SER A   593                                                      
REMARK 465     VAL A   594                                                      
REMARK 465     THR A   595                                                      
REMARK 465     THR A   596                                                      
REMARK 465     ASN A   597                                                      
REMARK 465     PRO A   598                                                      
REMARK 465     MET A   599                                                      
REMARK 465     CYS A   600                                                      
REMARK 465     ARG A   651                                                      
REMARK 465     GLY A   652                                                      
REMARK 465     SER A   653                                                      
REMARK 465     HIS A   654                                                      
REMARK 465     HIS A   655                                                      
REMARK 465     HIS A   656                                                      
REMARK 465     HIS A   657                                                      
REMARK 465     HIS A   658                                                      
REMARK 465     HIS A   659                                                      
REMARK 465     GLY A   660                                                      
REMARK 465     HIS A   661                                                      
REMARK 465     HIS A   662                                                      
REMARK 465     HIS A   663                                                      
REMARK 465     HIS A   664                                                      
REMARK 465     HIS A   665                                                      
REMARK 465     HIS A   666                                                      
REMARK 465     MET B    -1                                                      
REMARK 465     GLY B     0                                                      
REMARK 465     SER B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     GLY B     3                                                      
REMARK 465     LYS B     4                                                      
REMARK 465     ALA B     5                                                      
REMARK 465     ALA B     6                                                      
REMARK 465     GLU B     7                                                      
REMARK 465     GLU B     8                                                      
REMARK 465     ARG B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     PRO B    12                                                      
REMARK 465     LYS B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     THR B    16                                                      
REMARK 465     PRO B    17                                                      
REMARK 465     GLN B    18                                                      
REMARK 465     ASP B    19                                                      
REMARK 465     THR B    20                                                      
REMARK 465     SER B    21                                                      
REMARK 465     GLY B    22                                                      
REMARK 465     ASN B    45                                                      
REMARK 465     THR B    46                                                      
REMARK 465     LEU B    47                                                      
REMARK 465     GLU B    48                                                      
REMARK 465     VAL B    49                                                      
REMARK 465     ARG B    50                                                      
REMARK 465     ASP B    51                                                      
REMARK 465     LEU B    52                                                      
REMARK 465     ASN B    53                                                      
REMARK 465     TYR B    54                                                      
REMARK 465     GLN B    55                                                      
REMARK 465     VAL B    56                                                      
REMARK 465     ASP B    57                                                      
REMARK 465     LEU B    58                                                      
REMARK 465     ALA B    59                                                      
REMARK 465     SER B    60                                                      
REMARK 465     GLN B    61                                                      
REMARK 465     VAL B    62                                                      
REMARK 465     PRO B    63                                                      
REMARK 465     TRP B    64                                                      
REMARK 465     PHE B    65                                                      
REMARK 465     GLU B    66                                                      
REMARK 465     GLN B    67                                                      
REMARK 465     LEU B    68                                                      
REMARK 465     ALA B    69                                                      
REMARK 465     GLN B    70                                                      
REMARK 465     PHE B    71                                                      
REMARK 465     LYS B    72                                                      
REMARK 465     MET B    73                                                      
REMARK 465     PRO B    74                                                      
REMARK 465     TRP B    75                                                      
REMARK 465     THR B    76                                                      
REMARK 465     SER B    77                                                      
REMARK 465     PRO B    78                                                      
REMARK 465     SER B    79                                                      
REMARK 465     CYS B    80                                                      
REMARK 465     GLN B    81                                                      
REMARK 465     ASN B    82                                                      
REMARK 465     SER B    83                                                      
REMARK 465     CYS B    84                                                      
REMARK 465     GLU B    85                                                      
REMARK 465     LEU B    86                                                      
REMARK 465     VAL B   322                                                      
REMARK 465     ASP B   323                                                      
REMARK 465     LEU B   324                                                      
REMARK 465     THR B   325                                                      
REMARK 465     SER B   326                                                      
REMARK 465     ILE B   327                                                      
REMARK 465     ASP B   328                                                      
REMARK 465     ARG B   329                                                      
REMARK 465     ARG B   330                                                      
REMARK 465     SER B   331                                                      
REMARK 465     ARG B   332                                                      
REMARK 465     GLU B   333                                                      
REMARK 465     GLN B   334                                                      
REMARK 465     GLU B   335                                                      
REMARK 465     LEU B   336                                                      
REMARK 465     ALA B   337                                                      
REMARK 465     THR B   338                                                      
REMARK 465     ARG B   339                                                      
REMARK 465     GLU B   340                                                      
REMARK 465     LYS B   341                                                      
REMARK 465     ASP B   367                                                      
REMARK 465     LEU B   368                                                      
REMARK 465     ASP B   369                                                      
REMARK 465     GLU B   370                                                      
REMARK 465     ASP B   371                                                      
REMARK 465     THR B   372                                                      
REMARK 465     CYS B   373                                                      
REMARK 465     VAL B   374                                                      
REMARK 465     GLU B   375                                                      
REMARK 465     SER B   376                                                      
REMARK 465     SER B   377                                                      
REMARK 465     VAL B   378                                                      
REMARK 465     THR B   379                                                      
REMARK 465     PRO B   380                                                      
REMARK 465     LEU B   381                                                      
REMARK 465     ASP B   382                                                      
REMARK 465     THR B   383                                                      
REMARK 465     ASN B   384                                                      
REMARK 465     CYS B   385                                                      
REMARK 465     LEU B   386                                                      
REMARK 465     PRO B   387                                                      
REMARK 465     SER B   388                                                      
REMARK 465     PRO B   389                                                      
REMARK 465     THR B   390                                                      
REMARK 465     LYS B   391                                                      
REMARK 465     MET B   392                                                      
REMARK 465     PRO B   393                                                      
REMARK 465     ALA B   674                                                      
REMARK 465     SER B   675                                                      
REMARK 465     ASN B   676                                                      
REMARK 465     SER B   677                                                      
REMARK 465     LEU B   678                                                      
REMARK 465     GLU B   679                                                      
REMARK 465     VAL B   680                                                      
REMARK 465     LEU B   681                                                      
REMARK 465     PHE B   682                                                      
REMARK 465     GLN B   683                                                      
REMARK 465     MET D    -1                                                      
REMARK 465     GLY D     0                                                      
REMARK 465     SER D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     LYS D     4                                                      
REMARK 465     ALA D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     GLU D     8                                                      
REMARK 465     ARG D     9                                                      
REMARK 465     GLY D    10                                                      
REMARK 465     LEU D    11                                                      
REMARK 465     PRO D    12                                                      
REMARK 465     LYS D    13                                                      
REMARK 465     GLY D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     THR D    16                                                      
REMARK 465     PRO D    17                                                      
REMARK 465     GLN D    18                                                      
REMARK 465     ASP D    19                                                      
REMARK 465     THR D    20                                                      
REMARK 465     SER D    21                                                      
REMARK 465     GLY D    22                                                      
REMARK 465     LEU D    23                                                      
REMARK 465     ASN D    45                                                      
REMARK 465     THR D    46                                                      
REMARK 465     LEU D    47                                                      
REMARK 465     GLU D    48                                                      
REMARK 465     VAL D    49                                                      
REMARK 465     ARG D    50                                                      
REMARK 465     ASP D    51                                                      
REMARK 465     LEU D    52                                                      
REMARK 465     ASN D    53                                                      
REMARK 465     TYR D    54                                                      
REMARK 465     GLN D    55                                                      
REMARK 465     VAL D    56                                                      
REMARK 465     ASP D    57                                                      
REMARK 465     LEU D    58                                                      
REMARK 465     ALA D    59                                                      
REMARK 465     SER D    60                                                      
REMARK 465     GLN D    61                                                      
REMARK 465     VAL D    62                                                      
REMARK 465     PRO D    63                                                      
REMARK 465     TRP D    64                                                      
REMARK 465     PHE D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLN D    67                                                      
REMARK 465     LEU D    68                                                      
REMARK 465     ALA D    69                                                      
REMARK 465     GLN D    70                                                      
REMARK 465     PHE D    71                                                      
REMARK 465     LYS D    72                                                      
REMARK 465     MET D    73                                                      
REMARK 465     PRO D    74                                                      
REMARK 465     TRP D    75                                                      
REMARK 465     THR D    76                                                      
REMARK 465     SER D    77                                                      
REMARK 465     PRO D    78                                                      
REMARK 465     SER D    79                                                      
REMARK 465     CYS D    80                                                      
REMARK 465     GLN D    81                                                      
REMARK 465     ASN D    82                                                      
REMARK 465     SER D    83                                                      
REMARK 465     CYS D    84                                                      
REMARK 465     GLU D    85                                                      
REMARK 465     LEU D   356                                                      
REMARK 465     ASP D   357                                                      
REMARK 465     ASP D   358                                                      
REMARK 465     PHE D   359                                                      
REMARK 465     LEU D   360                                                      
REMARK 465     TRP D   361                                                      
REMARK 465     LYS D   362                                                      
REMARK 465     ALA D   363                                                      
REMARK 465     GLU D   364                                                      
REMARK 465     THR D   365                                                      
REMARK 465     LYS D   366                                                      
REMARK 465     ASP D   367                                                      
REMARK 465     LEU D   368                                                      
REMARK 465     ASP D   369                                                      
REMARK 465     GLU D   370                                                      
REMARK 465     ASP D   371                                                      
REMARK 465     THR D   372                                                      
REMARK 465     CYS D   373                                                      
REMARK 465     VAL D   374                                                      
REMARK 465     GLU D   375                                                      
REMARK 465     SER D   376                                                      
REMARK 465     SER D   377                                                      
REMARK 465     VAL D   378                                                      
REMARK 465     THR D   379                                                      
REMARK 465     PRO D   380                                                      
REMARK 465     LEU D   381                                                      
REMARK 465     ASP D   382                                                      
REMARK 465     THR D   383                                                      
REMARK 465     ASN D   384                                                      
REMARK 465     CYS D   385                                                      
REMARK 465     LEU D   386                                                      
REMARK 465     PRO D   387                                                      
REMARK 465     SER D   388                                                      
REMARK 465     PRO D   389                                                      
REMARK 465     SER D   670                                                      
REMARK 465     GLN D   671                                                      
REMARK 465     ASP D   672                                                      
REMARK 465     TRP D   673                                                      
REMARK 465     ALA D   674                                                      
REMARK 465     SER D   675                                                      
REMARK 465     ASN D   676                                                      
REMARK 465     SER D   677                                                      
REMARK 465     LEU D   678                                                      
REMARK 465     GLU D   679                                                      
REMARK 465     VAL D   680                                                      
REMARK 465     LEU D   681                                                      
REMARK 465     PHE D   682                                                      
REMARK 465     GLN D   683                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLU C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     LEU C     4                                                      
REMARK 465     SER C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     LEU C     7                                                      
REMARK 465     THR C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     GLY C    11                                                      
REMARK 465     SER C    12                                                      
REMARK 465     MET C    13                                                      
REMARK 465     GLY C    14                                                      
REMARK 465     LEU C    15                                                      
REMARK 465     GLN C    16                                                      
REMARK 465     VAL C    17                                                      
REMARK 465     ASN C    18                                                      
REMARK 465     ARG C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     GLN C    22                                                      
REMARK 465     SER C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     LEU C    25                                                      
REMARK 465     GLU C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     ALA C    28                                                      
REMARK 465     PRO C    29                                                      
REMARK 465     ALA C    30                                                      
REMARK 465     THR C    31                                                      
REMARK 465     ALA C    32                                                      
REMARK 465     PRO C    33                                                      
REMARK 465     GLU C    34                                                      
REMARK 465     PRO C    35                                                      
REMARK 465     VAL C    47                                                      
REMARK 465     SER C    48                                                      
REMARK 465     HIS C    49                                                      
REMARK 465     ARG C    50                                                      
REMARK 465     VAL C    51                                                      
REMARK 465     ARG C    52                                                      
REMARK 465     PRO C    53                                                      
REMARK 465     TRP C    54                                                      
REMARK 465     TRP C    55                                                      
REMARK 465     ASP C    56                                                      
REMARK 465     ILE C    57                                                      
REMARK 465     THR C    58                                                      
REMARK 465     SER C    59                                                      
REMARK 465     CYS C    60                                                      
REMARK 465     ARG C    61                                                      
REMARK 465     GLN C    62                                                      
REMARK 465     GLN C    63                                                      
REMARK 465     TRP C    64                                                      
REMARK 465     THR C    65                                                      
REMARK 465     ARG C    66                                                      
REMARK 465     LYS C   349                                                      
REMARK 465     THR C   350                                                      
REMARK 465     LEU C   351                                                      
REMARK 465     PRO C   352                                                      
REMARK 465     MET C   353                                                      
REMARK 465     VAL C   354                                                      
REMARK 465     SER C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     VAL C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     VAL C   594                                                      
REMARK 465     THR C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     ASN C   597                                                      
REMARK 465     PRO C   598                                                      
REMARK 465     SER C   650                                                      
REMARK 465     ARG C   651                                                      
REMARK 465     GLY C   652                                                      
REMARK 465     SER C   653                                                      
REMARK 465     HIS C   654                                                      
REMARK 465     HIS C   655                                                      
REMARK 465     HIS C   656                                                      
REMARK 465     HIS C   657                                                      
REMARK 465     HIS C   658                                                      
REMARK 465     HIS C   659                                                      
REMARK 465     GLY C   660                                                      
REMARK 465     HIS C   661                                                      
REMARK 465     HIS C   662                                                      
REMARK 465     HIS C   663                                                      
REMARK 465     HIS C   664                                                      
REMARK 465     HIS C   665                                                      
REMARK 465     HIS C   666                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OH   TYR D   293     O    ARG D   354              1.71            
REMARK 500   CZ   TYR C    75     OE2  GLU C    77              1.85            
REMARK 500   O    GLU D   335     OG1  THR D   338              1.87            
REMARK 500   OE2  GLU C   573     NH2  ARG C   619              1.87            
REMARK 500   OH   TYR C    75     OE2  GLU C    77              1.90            
REMARK 500   OE1  GLU B   423     ND2  ASN B   462              1.93            
REMARK 500   OD1  ASP A    97     OH   TYR A   131              1.95            
REMARK 500   O    SER D    97     O    ARG D   263              1.99            
REMARK 500   CE2  TYR C    75     OE2  GLU C    77              2.04            
REMARK 500   O    LEU B   630     O    MET B   633              2.05            
REMARK 500   OH   TYR D   293     C    ASP D   355              2.07            
REMARK 500   O    MET C   480     OG   SER C   484              2.08            
REMARK 500   O    MET A   480     OG   SER A   484              2.08            
REMARK 500   OG   SER C    90     OG1  THR C    93              2.10            
REMARK 500   O    PHE C   300     N    MET C   302              2.11            
REMARK 500   O    ILE B   134     N    GLY B   136              2.11            
REMARK 500   O    MET A   302     OG1  THR A   305              2.14            
REMARK 500   O    SER B   444     N    ASP B   447              2.15            
REMARK 500   O    PRO A   292     OG   SER A   295              2.15            
REMARK 500   O    LEU B    36     CG2  VAL B    95              2.15            
REMARK 500   O    VAL D   660     O    LEU D   662              2.16            
REMARK 500   O    ASN C   296     N    ASP C   299              2.17            
REMARK 500   O    VAL C   542     OG   SER C   546              2.18            
REMARK 500   N    GLU A    77     OE1  GLN A    80              2.19            
REMARK 500   N    GLU C    77     OE1  GLN C    80              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   OD1  ASP B   357     NH2  ARG D   339     6454     2.09            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ILE A  81   CB  -  CA  -  C   ANGL. DEV. = -13.1 DEGREES          
REMARK 500    TYR B  37   CA  -  CB  -  CG  ANGL. DEV. =  15.5 DEGREES          
REMARK 500    TYR B 571   CA  -  CB  -  CG  ANGL. DEV. =  15.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A  42       59.27     39.59                                   
REMARK 500    GLN A  67       66.97   -158.06                                   
REMARK 500    ASP A  71       63.22     28.65                                   
REMARK 500    SER A  90     -124.33     70.52                                   
REMARK 500    ARG A 118      162.81     69.80                                   
REMARK 500    PHE A 125      -70.07    -30.05                                   
REMARK 500    ASP A 136       68.64   -153.56                                   
REMARK 500    ARG A 158     -129.21   -146.53                                   
REMARK 500    PRO A 161       -9.24    -53.05                                   
REMARK 500    LEU A 184      108.94    -38.35                                   
REMARK 500    CYS A 225      -59.53    -29.81                                   
REMARK 500    ARG A 241       35.74    -78.24                                   
REMARK 500    HIS A 250      -79.38    -68.84                                   
REMARK 500    ILE A 272     -123.83   -126.51                                   
REMARK 500    ASN A 296       81.77     65.17                                   
REMARK 500    SER A 332      151.47    -48.09                                   
REMARK 500    MET A 353       38.23     38.36                                   
REMARK 500    PHE A 356      143.83   -170.42                                   
REMARK 500    LYS A 357      166.18    171.39                                   
REMARK 500    LYS A 359      -88.13   -107.17                                   
REMARK 500    PRO A 362     -135.23    -89.95                                   
REMARK 500    ASN A 378      -70.16    -44.44                                   
REMARK 500    ARG A 381       40.04    -92.89                                   
REMARK 500    LEU A 384      -64.06    -27.89                                   
REMARK 500    LEU A 405     -138.36     60.38                                   
REMARK 500    VAL A 407       98.49    -68.34                                   
REMARK 500    ASN A 410      -76.28    -49.37                                   
REMARK 500    ALA A 415      -78.45   -100.55                                   
REMARK 500    ASP A 450      -72.24    -48.79                                   
REMARK 500    HIS A 493      105.05    -12.72                                   
REMARK 500    ARG A 550       40.34   -157.69                                   
REMARK 500    ASN A 551       63.84     36.36                                   
REMARK 500    ILE A 552      -55.81    -26.89                                   
REMARK 500    ILE A 557      -86.42     -1.84                                   
REMARK 500    TYR A 581      -44.40    -27.90                                   
REMARK 500    PHE A 602     -159.29    -79.96                                   
REMARK 500    THR A 603      -51.24   -160.18                                   
REMARK 500    THR A 617      -57.75    -27.98                                   
REMARK 500    PHE A 620      -63.06    -27.08                                   
REMARK 500    ASP B  25      164.48     78.13                                   
REMARK 500    LEU B  27      129.54     66.53                                   
REMARK 500    SER B  30      135.34    163.80                                   
REMARK 500    ASP B  33      137.66    162.43                                   
REMARK 500    ASN B  34      160.99    179.29                                   
REMARK 500    TYR B  40       80.16     47.65                                   
REMARK 500    ASN B  90       67.76     65.22                                   
REMARK 500    SER B  97       56.33     18.78                                   
REMARK 500    SER B 107       86.13    -67.57                                   
REMARK 500    ILE B 127      147.53    -23.40                                   
REMARK 500    ASN B 135      -58.87     14.48                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     166 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLU A   34     PRO A   35                  149.20                    
REMARK 500 GLY A  104     ARG A  105                 -145.35                    
REMARK 500 GLY A  186     ASN A  187                  146.28                    
REMARK 500 GLY A  192     ILE A  193                  149.91                    
REMARK 500 ASP A  308     THR A  309                 -146.32                    
REMARK 500 LEU A  348     LYS A  349                  147.49                    
REMARK 500 LEU A  492     HIS A  493                 -142.79                    
REMARK 500 GLY A  547     PHE A  548                 -148.25                    
REMARK 500 GLU B   31     SER B   32                 -149.42                    
REMARK 500 SER B   32     ASP B   33                   98.64                    
REMARK 500 GLY B  490     PRO B  491                 -148.84                    
REMARK 500 GLN D   24     ASP D   25                 -138.85                    
REMARK 500 LYS D  126     ILE D  127                  147.66                    
REMARK 500 PRO D  272     ARG D  273                 -148.48                    
REMARK 500 LEU D  324     THR D  325                  139.95                    
REMARK 500 LEU D  583     TRP D  584                 -143.28                    
REMARK 500 GLN D  607     PHE D  608                 -148.72                    
REMARK 500 GLY C   89     SER C   90                  142.02                    
REMARK 500 GLY C  414     ALA C  415                 -148.87                    
REMARK 500 PHE C  602     THR C  603                 -138.62                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  5DO7 A    1   651  UNP    Q9H222   ABCG5_HUMAN      1    651             
DBREF  5DO7 B    2   673  UNP    Q9H221   ABCG8_HUMAN      2    673             
DBREF  5DO7 D    2   673  UNP    Q9H221   ABCG8_HUMAN      2    673             
DBREF  5DO7 C    1   651  UNP    Q9H222   ABCG5_HUMAN      1    651             
SEQADV 5DO7 GLU A    2  UNP  Q9H222    GLY     2 ENGINEERED MUTATION            
SEQADV 5DO7 GLY A  652  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 SER A  653  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  654  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  655  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  656  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  657  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  658  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  659  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 GLY A  660  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  661  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  662  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  663  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  664  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  665  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS A  666  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 MET B   -1  UNP  Q9H221              INITIATING METHIONINE          
SEQADV 5DO7 GLY B    0  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER B    1  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 ALA B  674  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER B  675  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 ASN B  676  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER B  677  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 LEU B  678  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 GLU B  679  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 VAL B  680  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 LEU B  681  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 PHE B  682  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 GLN B  683  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 MET D   -1  UNP  Q9H221              INITIATING METHIONINE          
SEQADV 5DO7 GLY D    0  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER D    1  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 ALA D  674  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER D  675  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 ASN D  676  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 SER D  677  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 LEU D  678  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 GLU D  679  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 VAL D  680  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 LEU D  681  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 PHE D  682  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 GLN D  683  UNP  Q9H221              EXPRESSION TAG                 
SEQADV 5DO7 GLU C    2  UNP  Q9H222    GLY     2 ENGINEERED MUTATION            
SEQADV 5DO7 GLY C  652  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 SER C  653  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  654  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  655  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  656  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  657  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  658  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  659  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 GLY C  660  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  661  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  662  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  663  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  664  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  665  UNP  Q9H222              EXPRESSION TAG                 
SEQADV 5DO7 HIS C  666  UNP  Q9H222              EXPRESSION TAG                 
SEQRES   1 A  666  MET GLU ASP LEU SER SER LEU THR PRO GLY GLY SER MET          
SEQRES   2 A  666  GLY LEU GLN VAL ASN ARG GLY SER GLN SER SER LEU GLU          
SEQRES   3 A  666  GLY ALA PRO ALA THR ALA PRO GLU PRO HIS SER LEU GLY          
SEQRES   4 A  666  ILE LEU HIS ALA SER TYR SER VAL SER HIS ARG VAL ARG          
SEQRES   5 A  666  PRO TRP TRP ASP ILE THR SER CYS ARG GLN GLN TRP THR          
SEQRES   6 A  666  ARG GLN ILE LEU LYS ASP VAL SER LEU TYR VAL GLU SER          
SEQRES   7 A  666  GLY GLN ILE MET CYS ILE LEU GLY SER SER GLY SER GLY          
SEQRES   8 A  666  LYS THR THR LEU LEU ASP ALA MET SER GLY ARG LEU GLY          
SEQRES   9 A  666  ARG ALA GLY THR PHE LEU GLY GLU VAL TYR VAL ASN GLY          
SEQRES  10 A  666  ARG ALA LEU ARG ARG GLU GLN PHE GLN ASP CYS PHE SER          
SEQRES  11 A  666  TYR VAL LEU GLN SER ASP THR LEU LEU SER SER LEU THR          
SEQRES  12 A  666  VAL ARG GLU THR LEU HIS TYR THR ALA LEU LEU ALA ILE          
SEQRES  13 A  666  ARG ARG GLY ASN PRO GLY SER PHE GLN LYS LYS VAL GLU          
SEQRES  14 A  666  ALA VAL MET ALA GLU LEU SER LEU SER HIS VAL ALA ASP          
SEQRES  15 A  666  ARG LEU ILE GLY ASN TYR SER LEU GLY GLY ILE SER THR          
SEQRES  16 A  666  GLY GLU ARG ARG ARG VAL SER ILE ALA ALA GLN LEU LEU          
SEQRES  17 A  666  GLN ASP PRO LYS VAL MET LEU PHE ASP GLU PRO THR THR          
SEQRES  18 A  666  GLY LEU ASP CYS MET THR ALA ASN GLN ILE VAL VAL LEU          
SEQRES  19 A  666  LEU VAL GLU LEU ALA ARG ARG ASN ARG ILE VAL VAL LEU          
SEQRES  20 A  666  THR ILE HIS GLN PRO ARG SER GLU LEU PHE GLN LEU PHE          
SEQRES  21 A  666  ASP LYS ILE ALA ILE LEU SER PHE GLY GLU LEU ILE PHE          
SEQRES  22 A  666  CYS GLY THR PRO ALA GLU MET LEU ASP PHE PHE ASN ASP          
SEQRES  23 A  666  CYS GLY TYR PRO CYS PRO GLU HIS SER ASN PRO PHE ASP          
SEQRES  24 A  666  PHE TYR MET ASP LEU THR SER VAL ASP THR GLN SER LYS          
SEQRES  25 A  666  GLU ARG GLU ILE GLU THR SER LYS ARG VAL GLN MET ILE          
SEQRES  26 A  666  GLU SER ALA TYR LYS LYS SER ALA ILE CYS HIS LYS THR          
SEQRES  27 A  666  LEU LYS ASN ILE GLU ARG MET LYS HIS LEU LYS THR LEU          
SEQRES  28 A  666  PRO MET VAL PRO PHE LYS THR LYS ASP SER PRO GLY VAL          
SEQRES  29 A  666  PHE SER LYS LEU GLY VAL LEU LEU ARG ARG VAL THR ARG          
SEQRES  30 A  666  ASN LEU VAL ARG ASN LYS LEU ALA VAL ILE THR ARG LEU          
SEQRES  31 A  666  LEU GLN ASN LEU ILE MET GLY LEU PHE LEU LEU PHE PHE          
SEQRES  32 A  666  VAL LEU ARG VAL ARG SER ASN VAL LEU LYS GLY ALA ILE          
SEQRES  33 A  666  GLN ASP ARG VAL GLY LEU LEU TYR GLN PHE VAL GLY ALA          
SEQRES  34 A  666  THR PRO TYR THR GLY MET LEU ASN ALA VAL ASN LEU PHE          
SEQRES  35 A  666  PRO VAL LEU ARG ALA VAL SER ASP GLN GLU SER GLN ASP          
SEQRES  36 A  666  GLY LEU TYR GLN LYS TRP GLN MET MET LEU ALA TYR ALA          
SEQRES  37 A  666  LEU HIS VAL LEU PRO PHE SER VAL VAL ALA THR MET ILE          
SEQRES  38 A  666  PHE SER SER VAL CYS TYR TRP THR LEU GLY LEU HIS PRO          
SEQRES  39 A  666  GLU VAL ALA ARG PHE GLY TYR PHE SER ALA ALA LEU LEU          
SEQRES  40 A  666  ALA PRO HIS LEU ILE GLY GLU PHE LEU THR LEU VAL LEU          
SEQRES  41 A  666  LEU GLY ILE VAL GLN ASN PRO ASN ILE VAL ASN SER VAL          
SEQRES  42 A  666  VAL ALA LEU LEU SER ILE ALA GLY VAL LEU VAL GLY SER          
SEQRES  43 A  666  GLY PHE LEU ARG ASN ILE GLN GLU MET PRO ILE PRO PHE          
SEQRES  44 A  666  LYS ILE ILE SER TYR PHE THR PHE GLN LYS TYR CYS SER          
SEQRES  45 A  666  GLU ILE LEU VAL VAL ASN GLU PHE TYR GLY LEU ASN PHE          
SEQRES  46 A  666  THR CYS GLY SER SER ASN VAL SER VAL THR THR ASN PRO          
SEQRES  47 A  666  MET CYS ALA PHE THR GLN GLY ILE GLN PHE ILE GLU LYS          
SEQRES  48 A  666  THR CYS PRO GLY ALA THR SER ARG PHE THR MET ASN PHE          
SEQRES  49 A  666  LEU ILE LEU TYR SER PHE ILE PRO ALA LEU VAL ILE LEU          
SEQRES  50 A  666  GLY ILE VAL VAL PHE LYS ILE ARG ASP HIS LEU ILE SER          
SEQRES  51 A  666  ARG GLY SER HIS HIS HIS HIS HIS HIS GLY HIS HIS HIS          
SEQRES  52 A  666  HIS HIS HIS                                                  
SEQRES   1 B  685  MET GLY SER ALA GLY LYS ALA ALA GLU GLU ARG GLY LEU          
SEQRES   2 B  685  PRO LYS GLY ALA THR PRO GLN ASP THR SER GLY LEU GLN          
SEQRES   3 B  685  ASP ARG LEU PHE SER SER GLU SER ASP ASN SER LEU TYR          
SEQRES   4 B  685  PHE THR TYR SER GLY GLN PRO ASN THR LEU GLU VAL ARG          
SEQRES   5 B  685  ASP LEU ASN TYR GLN VAL ASP LEU ALA SER GLN VAL PRO          
SEQRES   6 B  685  TRP PHE GLU GLN LEU ALA GLN PHE LYS MET PRO TRP THR          
SEQRES   7 B  685  SER PRO SER CYS GLN ASN SER CYS GLU LEU GLY ILE GLN          
SEQRES   8 B  685  ASN LEU SER PHE LYS VAL ARG SER GLY GLN MET LEU ALA          
SEQRES   9 B  685  ILE ILE GLY SER SER GLY CYS GLY ARG ALA SER LEU LEU          
SEQRES  10 B  685  ASP VAL ILE THR GLY ARG GLY HIS GLY GLY LYS ILE LYS          
SEQRES  11 B  685  SER GLY GLN ILE TRP ILE ASN GLY GLN PRO SER SER PRO          
SEQRES  12 B  685  GLN LEU VAL ARG LYS CYS VAL ALA HIS VAL ARG GLN HIS          
SEQRES  13 B  685  ASN GLN LEU LEU PRO ASN LEU THR VAL ARG GLU THR LEU          
SEQRES  14 B  685  ALA PHE ILE ALA GLN MET ARG LEU PRO ARG THR PHE SER          
SEQRES  15 B  685  GLN ALA GLN ARG ASP LYS ARG VAL GLU ASP VAL ILE ALA          
SEQRES  16 B  685  GLU LEU ARG LEU ARG GLN CYS ALA ASP THR ARG VAL GLY          
SEQRES  17 B  685  ASN MET TYR VAL ARG GLY LEU SER GLY GLY GLU ARG ARG          
SEQRES  18 B  685  ARG VAL SER ILE GLY VAL GLN LEU LEU TRP ASN PRO GLY          
SEQRES  19 B  685  ILE LEU ILE LEU ASP GLU PRO THR SER GLY LEU ASP SER          
SEQRES  20 B  685  PHE THR ALA HIS ASN LEU VAL LYS THR LEU SER ARG LEU          
SEQRES  21 B  685  ALA LYS GLY ASN ARG LEU VAL LEU ILE SER LEU HIS GLN          
SEQRES  22 B  685  PRO ARG SER ASP ILE PHE ARG LEU PHE ASP LEU VAL LEU          
SEQRES  23 B  685  LEU MET THR SER GLY THR PRO ILE TYR LEU GLY ALA ALA          
SEQRES  24 B  685  GLN HIS MET VAL GLN TYR PHE THR ALA ILE GLY TYR PRO          
SEQRES  25 B  685  CYS PRO ARG TYR SER ASN PRO ALA ASP PHE TYR VAL ASP          
SEQRES  26 B  685  LEU THR SER ILE ASP ARG ARG SER ARG GLU GLN GLU LEU          
SEQRES  27 B  685  ALA THR ARG GLU LYS ALA GLN SER LEU ALA ALA LEU PHE          
SEQRES  28 B  685  LEU GLU LYS VAL ARG ASP LEU ASP ASP PHE LEU TRP LYS          
SEQRES  29 B  685  ALA GLU THR LYS ASP LEU ASP GLU ASP THR CYS VAL GLU          
SEQRES  30 B  685  SER SER VAL THR PRO LEU ASP THR ASN CYS LEU PRO SER          
SEQRES  31 B  685  PRO THR LYS MET PRO GLY ALA VAL GLN GLN PHE THR THR          
SEQRES  32 B  685  LEU ILE ARG ARG GLN ILE SER ASN ASP PHE ARG ASP LEU          
SEQRES  33 B  685  PRO THR LEU LEU ILE HIS GLY ALA GLU ALA CYS LEU MET          
SEQRES  34 B  685  SER MET THR ILE GLY PHE LEU TYR PHE GLY HIS GLY SER          
SEQRES  35 B  685  ILE GLN LEU SER PHE MET ASP THR ALA ALA LEU LEU PHE          
SEQRES  36 B  685  MET ILE GLY ALA LEU ILE PRO PHE ASN VAL ILE LEU ASP          
SEQRES  37 B  685  VAL ILE SER LYS CYS TYR SER GLU ARG ALA MET LEU TYR          
SEQRES  38 B  685  TYR GLU LEU GLU ASP GLY LEU TYR THR THR GLY PRO TYR          
SEQRES  39 B  685  PHE PHE ALA LYS ILE LEU GLY GLU LEU PRO GLU HIS CYS          
SEQRES  40 B  685  ALA TYR ILE ILE ILE TYR GLY MET PRO THR TYR TRP LEU          
SEQRES  41 B  685  ALA ASN LEU ARG PRO GLY LEU GLN PRO PHE LEU LEU HIS          
SEQRES  42 B  685  PHE LEU LEU VAL TRP LEU VAL VAL PHE CYS CYS ARG ILE          
SEQRES  43 B  685  MET ALA LEU ALA ALA ALA ALA LEU LEU PRO THR PHE HIS          
SEQRES  44 B  685  MET ALA SER PHE PHE SER ASN ALA LEU TYR ASN SER PHE          
SEQRES  45 B  685  TYR LEU ALA GLY GLY PHE MET ILE ASN LEU SER SER LEU          
SEQRES  46 B  685  TRP THR VAL PRO ALA TRP ILE SER LYS VAL SER PHE LEU          
SEQRES  47 B  685  ARG TRP CYS PHE GLU GLY LEU MET LYS ILE GLN PHE SER          
SEQRES  48 B  685  ARG ARG THR TYR LYS MET PRO LEU GLY ASN LEU THR ILE          
SEQRES  49 B  685  ALA VAL SER GLY ASP LYS ILE LEU SER VAL MET GLU LEU          
SEQRES  50 B  685  ASP SER TYR PRO LEU TYR ALA ILE TYR LEU ILE VAL ILE          
SEQRES  51 B  685  GLY LEU SER GLY GLY PHE MET VAL LEU TYR TYR VAL SER          
SEQRES  52 B  685  LEU ARG PHE ILE LYS GLN LYS PRO SER GLN ASP TRP ALA          
SEQRES  53 B  685  SER ASN SER LEU GLU VAL LEU PHE GLN                          
SEQRES   1 D  685  MET GLY SER ALA GLY LYS ALA ALA GLU GLU ARG GLY LEU          
SEQRES   2 D  685  PRO LYS GLY ALA THR PRO GLN ASP THR SER GLY LEU GLN          
SEQRES   3 D  685  ASP ARG LEU PHE SER SER GLU SER ASP ASN SER LEU TYR          
SEQRES   4 D  685  PHE THR TYR SER GLY GLN PRO ASN THR LEU GLU VAL ARG          
SEQRES   5 D  685  ASP LEU ASN TYR GLN VAL ASP LEU ALA SER GLN VAL PRO          
SEQRES   6 D  685  TRP PHE GLU GLN LEU ALA GLN PHE LYS MET PRO TRP THR          
SEQRES   7 D  685  SER PRO SER CYS GLN ASN SER CYS GLU LEU GLY ILE GLN          
SEQRES   8 D  685  ASN LEU SER PHE LYS VAL ARG SER GLY GLN MET LEU ALA          
SEQRES   9 D  685  ILE ILE GLY SER SER GLY CYS GLY ARG ALA SER LEU LEU          
SEQRES  10 D  685  ASP VAL ILE THR GLY ARG GLY HIS GLY GLY LYS ILE LYS          
SEQRES  11 D  685  SER GLY GLN ILE TRP ILE ASN GLY GLN PRO SER SER PRO          
SEQRES  12 D  685  GLN LEU VAL ARG LYS CYS VAL ALA HIS VAL ARG GLN HIS          
SEQRES  13 D  685  ASN GLN LEU LEU PRO ASN LEU THR VAL ARG GLU THR LEU          
SEQRES  14 D  685  ALA PHE ILE ALA GLN MET ARG LEU PRO ARG THR PHE SER          
SEQRES  15 D  685  GLN ALA GLN ARG ASP LYS ARG VAL GLU ASP VAL ILE ALA          
SEQRES  16 D  685  GLU LEU ARG LEU ARG GLN CYS ALA ASP THR ARG VAL GLY          
SEQRES  17 D  685  ASN MET TYR VAL ARG GLY LEU SER GLY GLY GLU ARG ARG          
SEQRES  18 D  685  ARG VAL SER ILE GLY VAL GLN LEU LEU TRP ASN PRO GLY          
SEQRES  19 D  685  ILE LEU ILE LEU ASP GLU PRO THR SER GLY LEU ASP SER          
SEQRES  20 D  685  PHE THR ALA HIS ASN LEU VAL LYS THR LEU SER ARG LEU          
SEQRES  21 D  685  ALA LYS GLY ASN ARG LEU VAL LEU ILE SER LEU HIS GLN          
SEQRES  22 D  685  PRO ARG SER ASP ILE PHE ARG LEU PHE ASP LEU VAL LEU          
SEQRES  23 D  685  LEU MET THR SER GLY THR PRO ILE TYR LEU GLY ALA ALA          
SEQRES  24 D  685  GLN HIS MET VAL GLN TYR PHE THR ALA ILE GLY TYR PRO          
SEQRES  25 D  685  CYS PRO ARG TYR SER ASN PRO ALA ASP PHE TYR VAL ASP          
SEQRES  26 D  685  LEU THR SER ILE ASP ARG ARG SER ARG GLU GLN GLU LEU          
SEQRES  27 D  685  ALA THR ARG GLU LYS ALA GLN SER LEU ALA ALA LEU PHE          
SEQRES  28 D  685  LEU GLU LYS VAL ARG ASP LEU ASP ASP PHE LEU TRP LYS          
SEQRES  29 D  685  ALA GLU THR LYS ASP LEU ASP GLU ASP THR CYS VAL GLU          
SEQRES  30 D  685  SER SER VAL THR PRO LEU ASP THR ASN CYS LEU PRO SER          
SEQRES  31 D  685  PRO THR LYS MET PRO GLY ALA VAL GLN GLN PHE THR THR          
SEQRES  32 D  685  LEU ILE ARG ARG GLN ILE SER ASN ASP PHE ARG ASP LEU          
SEQRES  33 D  685  PRO THR LEU LEU ILE HIS GLY ALA GLU ALA CYS LEU MET          
SEQRES  34 D  685  SER MET THR ILE GLY PHE LEU TYR PHE GLY HIS GLY SER          
SEQRES  35 D  685  ILE GLN LEU SER PHE MET ASP THR ALA ALA LEU LEU PHE          
SEQRES  36 D  685  MET ILE GLY ALA LEU ILE PRO PHE ASN VAL ILE LEU ASP          
SEQRES  37 D  685  VAL ILE SER LYS CYS TYR SER GLU ARG ALA MET LEU TYR          
SEQRES  38 D  685  TYR GLU LEU GLU ASP GLY LEU TYR THR THR GLY PRO TYR          
SEQRES  39 D  685  PHE PHE ALA LYS ILE LEU GLY GLU LEU PRO GLU HIS CYS          
SEQRES  40 D  685  ALA TYR ILE ILE ILE TYR GLY MET PRO THR TYR TRP LEU          
SEQRES  41 D  685  ALA ASN LEU ARG PRO GLY LEU GLN PRO PHE LEU LEU HIS          
SEQRES  42 D  685  PHE LEU LEU VAL TRP LEU VAL VAL PHE CYS CYS ARG ILE          
SEQRES  43 D  685  MET ALA LEU ALA ALA ALA ALA LEU LEU PRO THR PHE HIS          
SEQRES  44 D  685  MET ALA SER PHE PHE SER ASN ALA LEU TYR ASN SER PHE          
SEQRES  45 D  685  TYR LEU ALA GLY GLY PHE MET ILE ASN LEU SER SER LEU          
SEQRES  46 D  685  TRP THR VAL PRO ALA TRP ILE SER LYS VAL SER PHE LEU          
SEQRES  47 D  685  ARG TRP CYS PHE GLU GLY LEU MET LYS ILE GLN PHE SER          
SEQRES  48 D  685  ARG ARG THR TYR LYS MET PRO LEU GLY ASN LEU THR ILE          
SEQRES  49 D  685  ALA VAL SER GLY ASP LYS ILE LEU SER VAL MET GLU LEU          
SEQRES  50 D  685  ASP SER TYR PRO LEU TYR ALA ILE TYR LEU ILE VAL ILE          
SEQRES  51 D  685  GLY LEU SER GLY GLY PHE MET VAL LEU TYR TYR VAL SER          
SEQRES  52 D  685  LEU ARG PHE ILE LYS GLN LYS PRO SER GLN ASP TRP ALA          
SEQRES  53 D  685  SER ASN SER LEU GLU VAL LEU PHE GLN                          
SEQRES   1 C  666  MET GLU ASP LEU SER SER LEU THR PRO GLY GLY SER MET          
SEQRES   2 C  666  GLY LEU GLN VAL ASN ARG GLY SER GLN SER SER LEU GLU          
SEQRES   3 C  666  GLY ALA PRO ALA THR ALA PRO GLU PRO HIS SER LEU GLY          
SEQRES   4 C  666  ILE LEU HIS ALA SER TYR SER VAL SER HIS ARG VAL ARG          
SEQRES   5 C  666  PRO TRP TRP ASP ILE THR SER CYS ARG GLN GLN TRP THR          
SEQRES   6 C  666  ARG GLN ILE LEU LYS ASP VAL SER LEU TYR VAL GLU SER          
SEQRES   7 C  666  GLY GLN ILE MET CYS ILE LEU GLY SER SER GLY SER GLY          
SEQRES   8 C  666  LYS THR THR LEU LEU ASP ALA MET SER GLY ARG LEU GLY          
SEQRES   9 C  666  ARG ALA GLY THR PHE LEU GLY GLU VAL TYR VAL ASN GLY          
SEQRES  10 C  666  ARG ALA LEU ARG ARG GLU GLN PHE GLN ASP CYS PHE SER          
SEQRES  11 C  666  TYR VAL LEU GLN SER ASP THR LEU LEU SER SER LEU THR          
SEQRES  12 C  666  VAL ARG GLU THR LEU HIS TYR THR ALA LEU LEU ALA ILE          
SEQRES  13 C  666  ARG ARG GLY ASN PRO GLY SER PHE GLN LYS LYS VAL GLU          
SEQRES  14 C  666  ALA VAL MET ALA GLU LEU SER LEU SER HIS VAL ALA ASP          
SEQRES  15 C  666  ARG LEU ILE GLY ASN TYR SER LEU GLY GLY ILE SER THR          
SEQRES  16 C  666  GLY GLU ARG ARG ARG VAL SER ILE ALA ALA GLN LEU LEU          
SEQRES  17 C  666  GLN ASP PRO LYS VAL MET LEU PHE ASP GLU PRO THR THR          
SEQRES  18 C  666  GLY LEU ASP CYS MET THR ALA ASN GLN ILE VAL VAL LEU          
SEQRES  19 C  666  LEU VAL GLU LEU ALA ARG ARG ASN ARG ILE VAL VAL LEU          
SEQRES  20 C  666  THR ILE HIS GLN PRO ARG SER GLU LEU PHE GLN LEU PHE          
SEQRES  21 C  666  ASP LYS ILE ALA ILE LEU SER PHE GLY GLU LEU ILE PHE          
SEQRES  22 C  666  CYS GLY THR PRO ALA GLU MET LEU ASP PHE PHE ASN ASP          
SEQRES  23 C  666  CYS GLY TYR PRO CYS PRO GLU HIS SER ASN PRO PHE ASP          
SEQRES  24 C  666  PHE TYR MET ASP LEU THR SER VAL ASP THR GLN SER LYS          
SEQRES  25 C  666  GLU ARG GLU ILE GLU THR SER LYS ARG VAL GLN MET ILE          
SEQRES  26 C  666  GLU SER ALA TYR LYS LYS SER ALA ILE CYS HIS LYS THR          
SEQRES  27 C  666  LEU LYS ASN ILE GLU ARG MET LYS HIS LEU LYS THR LEU          
SEQRES  28 C  666  PRO MET VAL PRO PHE LYS THR LYS ASP SER PRO GLY VAL          
SEQRES  29 C  666  PHE SER LYS LEU GLY VAL LEU LEU ARG ARG VAL THR ARG          
SEQRES  30 C  666  ASN LEU VAL ARG ASN LYS LEU ALA VAL ILE THR ARG LEU          
SEQRES  31 C  666  LEU GLN ASN LEU ILE MET GLY LEU PHE LEU LEU PHE PHE          
SEQRES  32 C  666  VAL LEU ARG VAL ARG SER ASN VAL LEU LYS GLY ALA ILE          
SEQRES  33 C  666  GLN ASP ARG VAL GLY LEU LEU TYR GLN PHE VAL GLY ALA          
SEQRES  34 C  666  THR PRO TYR THR GLY MET LEU ASN ALA VAL ASN LEU PHE          
SEQRES  35 C  666  PRO VAL LEU ARG ALA VAL SER ASP GLN GLU SER GLN ASP          
SEQRES  36 C  666  GLY LEU TYR GLN LYS TRP GLN MET MET LEU ALA TYR ALA          
SEQRES  37 C  666  LEU HIS VAL LEU PRO PHE SER VAL VAL ALA THR MET ILE          
SEQRES  38 C  666  PHE SER SER VAL CYS TYR TRP THR LEU GLY LEU HIS PRO          
SEQRES  39 C  666  GLU VAL ALA ARG PHE GLY TYR PHE SER ALA ALA LEU LEU          
SEQRES  40 C  666  ALA PRO HIS LEU ILE GLY GLU PHE LEU THR LEU VAL LEU          
SEQRES  41 C  666  LEU GLY ILE VAL GLN ASN PRO ASN ILE VAL ASN SER VAL          
SEQRES  42 C  666  VAL ALA LEU LEU SER ILE ALA GLY VAL LEU VAL GLY SER          
SEQRES  43 C  666  GLY PHE LEU ARG ASN ILE GLN GLU MET PRO ILE PRO PHE          
SEQRES  44 C  666  LYS ILE ILE SER TYR PHE THR PHE GLN LYS TYR CYS SER          
SEQRES  45 C  666  GLU ILE LEU VAL VAL ASN GLU PHE TYR GLY LEU ASN PHE          
SEQRES  46 C  666  THR CYS GLY SER SER ASN VAL SER VAL THR THR ASN PRO          
SEQRES  47 C  666  MET CYS ALA PHE THR GLN GLY ILE GLN PHE ILE GLU LYS          
SEQRES  48 C  666  THR CYS PRO GLY ALA THR SER ARG PHE THR MET ASN PHE          
SEQRES  49 C  666  LEU ILE LEU TYR SER PHE ILE PRO ALA LEU VAL ILE LEU          
SEQRES  50 C  666  GLY ILE VAL VAL PHE LYS ILE ARG ASP HIS LEU ILE SER          
SEQRES  51 C  666  ARG GLY SER HIS HIS HIS HIS HIS HIS GLY HIS HIS HIS          
SEQRES  52 C  666  HIS HIS HIS                                                  
HELIX    1 AA1 GLY A   91  SER A  100  1                                  10    
HELIX    2 AA2 GLN A  124  PHE A  129  1                                   6    
HELIX    3 AA3 THR A  143  ILE A  156  1                                  14    
HELIX    4 AA4 GLY A  162  LEU A  175  1                                  14    
HELIX    5 AA5 LEU A  177  ALA A  181  5                                   5    
HELIX    6 AA6 SER A  194  LEU A  208  1                                  15    
HELIX    7 AA7 ASP A  224  ARG A  241  1                                  18    
HELIX    8 AA8 GLU A  255  PHE A  260  5                                   6    
HELIX    9 AA9 THR A  276  CYS A  287  1                                  12    
HELIX   10 AB1 ASN A  296  SER A  306  1                                  11    
HELIX   11 AB2 SER A  311  SER A  332  1                                  22    
HELIX   12 AB3 SER A  332  LEU A  348  1                                  17    
HELIX   13 AB4 GLY A  363  ARG A  381  1                                  19    
HELIX   14 AB5 ASN A  382  LEU A  405  1                                  24    
HELIX   15 AB6 ALA A  415  GLY A  428  1                                  14    
HELIX   16 AB7 PRO A  431  GLN A  454  1                                  24    
HELIX   17 AB8 GLN A  459  GLY A  491  1                                  33    
HELIX   18 AB9 GLU A  495  LEU A  506  1                                  12    
HELIX   19 AC1 LEU A  506  VAL A  524  1                                  19    
HELIX   20 AC2 PRO A  527  SER A  546  1                                  20    
HELIX   21 AC3 ASN A  551  MET A  555  5                                   5    
HELIX   22 AC4 PRO A  556  TYR A  564  1                                   9    
HELIX   23 AC5 THR A  566  TYR A  581  1                                  16    
HELIX   24 AC6 GLY A  605  CYS A  613  1                                   9    
HELIX   25 AC7 GLY A  615  ILE A  649  1                                  35    
HELIX   26 AC8 GLY B  110  GLY B  120  1                                  11    
HELIX   27 AC9 SER B  140  VAL B  148  1                                   9    
HELIX   28 AD1 THR B  162  LEU B  175  1                                  14    
HELIX   29 AD2 SER B  180  ALA B  193  1                                  14    
HELIX   30 AD3 GLY B  206  ARG B  211  1                                   6    
HELIX   31 AD4 SER B  214  VAL B  225  1                                  12    
HELIX   32 AD5 GLN B  226  ASN B  230  5                                   5    
HELIX   33 AD6 ASP B  244  GLY B  261  1                                  18    
HELIX   34 AD7 ARG B  273  LEU B  279  1                                   7    
HELIX   35 AD8 ALA B  297  PHE B  304  1                                   8    
HELIX   36 AD9 THR B  305  ILE B  307  5                                   3    
HELIX   37 AE1 SER B  315  TYR B  321  1                                   7    
HELIX   38 AE2 SER B  344  LYS B  366  1                                  23    
HELIX   39 AE3 ALA B  395  ASP B  413  1                                  19    
HELIX   40 AE4 ASP B  413  TYR B  435  1                                  23    
HELIX   41 AE5 SER B  444  LEU B  458  1                                  15    
HELIX   42 AE6 ILE B  459  SER B  473  1                                  15    
HELIX   43 AE7 ARG B  475  ASP B  484  1                                  10    
HELIX   44 AE8 TYR B  492  GLU B  500  1                                   9    
HELIX   45 AE9 GLU B  500  ALA B  519  1                                  20    
HELIX   46 AF1 LEU B  525  LEU B  553  1                                  29    
HELIX   47 AF2 THR B  555  GLY B  574  1                                  20    
HELIX   48 AF3 GLY B  574  ASN B  579  1                                   6    
HELIX   49 AF4 TRP B  584  LYS B  592  1                                   9    
HELIX   50 AF5 SER B  594  SER B  609  1                                  16    
HELIX   51 AF6 ASP B  627  MET B  633  1                                   7    
HELIX   52 AF7 GLU B  634  TYR B  638  5                                   5    
HELIX   53 AF8 TYR B  641  ILE B  665  1                                  25    
HELIX   54 AF9 GLY D  110  GLY D  120  1                                  11    
HELIX   55 AG1 SER D  140  VAL D  148  1                                   9    
HELIX   56 AG2 THR D  162  LEU D  175  1                                  14    
HELIX   57 AG3 SER D  180  ALA D  193  1                                  14    
HELIX   58 AG4 SER D  214  VAL D  225  1                                  12    
HELIX   59 AG5 GLN D  226  ASN D  230  5                                   5    
HELIX   60 AG6 ASP D  244  GLY D  261  1                                  18    
HELIX   61 AG7 ARG D  273  LEU D  279  1                                   7    
HELIX   62 AG8 GLN D  298  PHE D  304  1                                   7    
HELIX   63 AG9 THR D  305  ILE D  307  5                                   3    
HELIX   64 AH1 TYR D  314  TYR D  321  1                                   8    
HELIX   65 AH2 SER D  326  GLU D  335  1                                  10    
HELIX   66 AH3 GLU D  335  LEU D  348  1                                  14    
HELIX   67 AH4 GLY D  394  ASP D  413  1                                  20    
HELIX   68 AH5 ASP D  413  TYR D  435  1                                  23    
HELIX   69 AH6 SER D  444  LEU D  458  1                                  15    
HELIX   70 AH7 ILE D  459  SER D  473  1                                  15    
HELIX   71 AH8 ARG D  475  ASP D  484  1                                  10    
HELIX   72 AH9 PHE D  494  GLU D  500  1                                   7    
HELIX   73 AI1 GLU D  500  ALA D  519  1                                  20    
HELIX   74 AI2 LEU D  525  LEU D  553  1                                  29    
HELIX   75 AI3 THR D  555  GLY D  574  1                                  20    
HELIX   76 AI4 GLY D  574  ASN D  579  1                                   6    
HELIX   77 AI5 PRO D  587  VAL D  593  5                                   7    
HELIX   78 AI6 SER D  594  SER D  609  1                                  16    
HELIX   79 AI7 ASP D  627  GLU D  634  1                                   8    
HELIX   80 AI8 TYR D  641  ILE D  665  1                                  25    
HELIX   81 AI9 SER C   90  SER C  100  1                                  11    
HELIX   82 AJ1 GLN C  124  PHE C  129  1                                   6    
HELIX   83 AJ2 THR C  143  ILE C  156  1                                  14    
HELIX   84 AJ3 GLY C  162  SER C  176  1                                  15    
HELIX   85 AJ4 LEU C  177  ALA C  181  5                                   5    
HELIX   86 AJ5 SER C  194  GLN C  206  1                                  13    
HELIX   87 AJ6 ASP C  224  ARG C  241  1                                  18    
HELIX   88 AJ7 LEU C  256  PHE C  260  5                                   5    
HELIX   89 AJ8 THR C  276  CYS C  287  1                                  12    
HELIX   90 AJ9 ASN C  296  SER C  306  1                                  11    
HELIX   91 AK1 LYS C  312  SER C  332  1                                  21    
HELIX   92 AK2 SER C  332  MET C  345  1                                  14    
HELIX   93 AK3 GLY C  363  ARG C  381  1                                  19    
HELIX   94 AK4 ASN C  382  LEU C  405  1                                  24    
HELIX   95 AK5 ILE C  416  GLY C  428  1                                  13    
HELIX   96 AK6 PRO C  431  GLN C  454  1                                  24    
HELIX   97 AK7 GLN C  459  GLY C  491  1                                  33    
HELIX   98 AK8 GLU C  495  LEU C  506  1                                  12    
HELIX   99 AK9 LEU C  506  VAL C  524  1                                  19    
HELIX  100 AL1 PRO C  527  SER C  546  1                                  20    
HELIX  101 AL2 ASN C  551  MET C  555  5                                   5    
HELIX  102 AL3 PRO C  556  TYR C  564  1                                   9    
HELIX  103 AL4 THR C  566  TYR C  581  1                                  16    
HELIX  104 AL5 GLY C  605  CYS C  613  1                                   9    
HELIX  105 AL6 GLY C  615  ILE C  649  1                                  35    
SHEET    1 AA1 3 LEU A  69  GLU A  77  0                                        
SHEET    2 AA1 3 SER A  37  TYR A  45 -1  N  LEU A  38   O  VAL A  76           
SHEET    3 AA1 3 PHE A 109  VAL A 115 -1  O  TYR A 114   N  GLY A  39           
SHEET    1 AA2 6 SER A 130  VAL A 132  0                                        
SHEET    2 AA2 6 VAL A 213  ASP A 217  1  O  ASP A 217   N  VAL A 132           
SHEET    3 AA2 6 ILE A 244  THR A 248  1  O  VAL A 246   N  PHE A 216           
SHEET    4 AA2 6 ILE A  81  GLY A  86  1  N  MET A  82   O  VAL A 245           
SHEET    5 AA2 6 LYS A 262  SER A 267  1  O  LYS A 262   N  CYS A  83           
SHEET    6 AA2 6 GLU A 270  GLY A 275 -1  O  GLU A 270   N  SER A 267           
SHEET    1 AA3 3 VAL B  95  ARG B  96  0                                        
SHEET    2 AA3 3 SER B  35  GLY B  42 -1  N  LEU B  36   O  VAL B  95           
SHEET    3 AA3 3 SER B 129  ILE B 134 -1  O  TRP B 133   N  TYR B  37           
SHEET    1 AA4 6 HIS B 150  VAL B 151  0                                        
SHEET    2 AA4 6 ILE B 233  ASP B 237  1  O  ASP B 237   N  VAL B 151           
SHEET    3 AA4 6 LEU B 264  SER B 268  1  O  LEU B 266   N  LEU B 236           
SHEET    4 AA4 6 MET B 100  ILE B 103  1  N  LEU B 101   O  VAL B 265           
SHEET    5 AA4 6 LEU B 282  THR B 287  1  O  LEU B 282   N  MET B 100           
SHEET    6 AA4 6 THR B 290  ALA B 296 -1  O  GLY B 295   N  VAL B 283           
SHEET    1 AA5 2 TYR B 613  LYS B 614  0                                        
SHEET    2 AA5 2 SER B 625  GLY B 626 -1  O  SER B 625   N  LYS B 614           
SHEET    1 AA6 4 LYS D  94  ARG D  96  0                                        
SHEET    2 AA6 4 SER D  35  GLY D  42 -1  N  LEU D  36   O  VAL D  95           
SHEET    3 AA6 4 SER D 129  ILE D 134 -1  O  TRP D 133   N  TYR D  37           
SHEET    4 AA6 4 GLN D 137  PRO D 138 -1  O  GLN D 137   N  ILE D 134           
SHEET    1 AA7 6 HIS D 150  VAL D 151  0                                        
SHEET    2 AA7 6 ILE D 233  ASP D 237  1  O  ASP D 237   N  VAL D 151           
SHEET    3 AA7 6 LEU D 264  SER D 268  1  O  LEU D 266   N  LEU D 236           
SHEET    4 AA7 6 MET D 100  ILE D 103  1  N  LEU D 101   O  VAL D 265           
SHEET    5 AA7 6 LEU D 282  THR D 287  1  O  LEU D 282   N  MET D 100           
SHEET    6 AA7 6 THR D 290  ALA D 296 -1  O  GLY D 295   N  VAL D 283           
SHEET    1 AA8 3 LEU C  69  GLU C  77  0                                        
SHEET    2 AA8 3 SER C  37  TYR C  45 -1  N  LEU C  38   O  VAL C  76           
SHEET    3 AA8 3 PHE C 109  VAL C 115 -1  O  TYR C 114   N  GLY C  39           
SHEET    1 AA9 6 SER C 130  VAL C 132  0                                        
SHEET    2 AA9 6 VAL C 213  ASP C 217  1  O  ASP C 217   N  VAL C 132           
SHEET    3 AA9 6 ILE C 244  THR C 248  1  O  VAL C 246   N  PHE C 216           
SHEET    4 AA9 6 ILE C  81  GLY C  86  1  N  MET C  82   O  LEU C 247           
SHEET    5 AA9 6 LYS C 262  SER C 267  1  O  ALA C 264   N  CYS C  83           
SHEET    6 AA9 6 GLU C 270  GLY C 275 -1  O  GLU C 270   N  SER C 267           
CISPEP   1 LEU C  103    GLY C  104          0        -1.77                     
CRYST1  173.552  224.804  253.304  90.00  90.00  90.00 I 2 2 2      16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005762  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.004448  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003948        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system