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Database: PDB
Entry: 5K19
LinkDB: 5K19
Original site: 5K19 
HEADER    UNKNOWN FUNCTION                        17-MAY-16   5K19              
TITLE     CRYSTAL STRUCTURE OF WD REPEAT-CONTAINING PROTEIN 20                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: WD REPEAT-CONTAINING PROTEIN 20;                           
COMPND   3 CHAIN: A, B, C;                                                      
COMPND   4 SYNONYM: PROTEIN DMR;                                                
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: WDR20;                                                         
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12;                            
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 83333                                       
KEYWDS    WDR20, UNKNOWN FUNCTION                                               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    H.LI,A.D.D'ANDREA,N.ZHENG                                             
REVDAT   4   20-NOV-19 5K19    1       REMARK                                   
REVDAT   3   20-SEP-17 5K19    1       JRNL   REMARK                            
REVDAT   2   10-AUG-16 5K19    1       JRNL                                     
REVDAT   1   20-JUL-16 5K19    0                                                
JRNL        AUTH   H.LI,K.S.LIM,H.KIM,T.R.HINDS,U.JO,H.MAO,C.E.WELLER,J.SUN,    
JRNL        AUTH 2 C.CHATTERJEE,A.D.D'ANDREA,N.ZHENG                            
JRNL        TITL   ALLOSTERIC ACTIVATION OF UBIQUITIN-SPECIFIC PROTEASES BY     
JRNL        TITL 2 BETA-PROPELLER PROTEINS UAF1 AND WDR20.                      
JRNL        REF    MOL.CELL                      V.  63   249 2016              
JRNL        REFN                   ISSN 1097-2765                               
JRNL        PMID   27373336                                                     
JRNL        DOI    10.1016/J.MOLCEL.2016.05.031                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX DEV_1760                                      
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.60                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 45.63                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.960                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 46508                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.194                           
REMARK   3   R VALUE            (WORKING SET) : 0.191                           
REMARK   3   FREE R VALUE                     : 0.257                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.810                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2239                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 45.6327 -  6.5501    0.97     2701   153  0.1614 0.2251        
REMARK   3     2  6.5501 -  5.2014    0.97     2703   150  0.1703 0.2104        
REMARK   3     3  5.2014 -  4.5446    0.97     2777    85  0.1324 0.1605        
REMARK   3     4  4.5446 -  4.1294    0.98     2774   115  0.1475 0.2211        
REMARK   3     5  4.1294 -  3.8336    0.99     2756   167  0.1733 0.2275        
REMARK   3     6  3.8336 -  3.6076    0.99     2747   154  0.1935 0.2855        
REMARK   3     7  3.6076 -  3.4270    0.99     2800    96  0.2013 0.2304        
REMARK   3     8  3.4270 -  3.2779    0.99     2780   124  0.2103 0.2843        
REMARK   3     9  3.2779 -  3.1517    0.99     2858    96  0.2304 0.2710        
REMARK   3    10  3.1517 -  3.0430    1.00     2755   162  0.2378 0.3508        
REMARK   3    11  3.0430 -  2.9479    1.00     2780   160  0.2501 0.3382        
REMARK   3    12  2.9479 -  2.8636    1.00     2778   156  0.2645 0.3177        
REMARK   3    13  2.8636 -  2.7882    1.00     2744   136  0.2828 0.3631        
REMARK   3    14  2.7882 -  2.7202    1.00     2780   180  0.2951 0.3335        
REMARK   3    15  2.7202 -  2.6584    1.00     2782   156  0.3148 0.3354        
REMARK   3    16  2.6584 -  2.6018    0.99     2754   149  0.3524 0.4048        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.410            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.250           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.009           8722                                  
REMARK   3   ANGLE     :  1.255          11866                                  
REMARK   3   CHIRALITY :  0.048           1343                                  
REMARK   3   PLANARITY :  0.006           1500                                  
REMARK   3   DIHEDRAL  : 14.579           2965                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5K19 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-MAY-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000221564.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-NOV-14                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ALS                                
REMARK 200  BEAMLINE                       : 8.2.1                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0                                
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 46508                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.600                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.8                               
REMARK 200  DATA REDUNDANCY                : 2.800                              
REMARK 200  R MERGE                    (I) : 0.08900                            
REMARK 200  R SYM                      (I) : 0.10000                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 19.8000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.60                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.64                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.1                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.40                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.89800                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.500                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 1ERJ                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 41.36                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.10                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M SODIUM CITRATE, 7% PEG 3350,       
REMARK 280  0.15 M NACL, PH 5.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE     
REMARK 280  277.0K                                                              
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31                             
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       31.76900            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       63.53800            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3                                                 
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     GLU A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     GLY A     6                                                      
REMARK 465     GLY A     7                                                      
REMARK 465     LYS A     8                                                      
REMARK 465     GLU A     9                                                      
REMARK 465     MET A    10                                                      
REMARK 465     GLN A    43                                                      
REMARK 465     GLY A    44                                                      
REMARK 465     ASP A    57                                                      
REMARK 465     GLN A    58                                                      
REMARK 465     SER A   206                                                      
REMARK 465     LYS A   207                                                      
REMARK 465     SER A   208                                                      
REMARK 465     PRO A   324                                                      
REMARK 465     MET A   325                                                      
REMARK 465     GLU A   326                                                      
REMARK 465     PHE A   327                                                      
REMARK 465     SER A   328                                                      
REMARK 465     GLY A   329                                                      
REMARK 465     SER A   330                                                      
REMARK 465     ASP A   331                                                      
REMARK 465     GLU A   332                                                      
REMARK 465     ASP A   333                                                      
REMARK 465     PHE A   334                                                      
REMARK 465     GLN A   335                                                      
REMARK 465     ASP A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     LEU A   338                                                      
REMARK 465     HIS A   339                                                      
REMARK 465     PHE A   340                                                      
REMARK 465     GLY A   341                                                      
REMARK 465     ARG A   342                                                      
REMARK 465     ASP A   343                                                      
REMARK 465     ARG A   344                                                      
REMARK 465     ALA A   345                                                      
REMARK 465     ASN A   346                                                      
REMARK 465     SER A   347                                                      
REMARK 465     THR A   348                                                      
REMARK 465     GLN A   349                                                      
REMARK 465     SER A   350                                                      
REMARK 465     ARG A   351                                                      
REMARK 465     LEU A   352                                                      
REMARK 465     SER A   353                                                      
REMARK 465     LYS A   354                                                      
REMARK 465     ARG A   355                                                      
REMARK 465     ASN A   356                                                      
REMARK 465     SER A   357                                                      
REMARK 465     THR A   358                                                      
REMARK 465     ASP A   359                                                      
REMARK 465     SER A   360                                                      
REMARK 465     ARG A   361                                                      
REMARK 465     PRO A   362                                                      
REMARK 465     VAL A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     HIS A   391                                                      
REMARK 465     GLN A   392                                                      
REMARK 465     PRO A   393                                                      
REMARK 465     LEU A   394                                                      
REMARK 465     SER A   395                                                      
REMARK 465     ARG A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     ARG A   398                                                      
REMARK 465     THR A   399                                                      
REMARK 465     HIS A   400                                                      
REMARK 465     THR A   401                                                      
REMARK 465     ASN A   402                                                      
REMARK 465     VAL A   403                                                      
REMARK 465     MET A   404                                                      
REMARK 465     ASN A   405                                                      
REMARK 465     ALA A   406                                                      
REMARK 465     THR A   407                                                      
REMARK 465     SER A   408                                                      
REMARK 465     PRO A   409                                                      
REMARK 465     PRO A   410                                                      
REMARK 465     ALA A   411                                                      
REMARK 465     GLY A   412                                                      
REMARK 465     SER A   413                                                      
REMARK 465     ASN A   414                                                      
REMARK 465     GLY A   415                                                      
REMARK 465     ASN A   416                                                      
REMARK 465     SER A   417                                                      
REMARK 465     VAL A   418                                                      
REMARK 465     THR A   419                                                      
REMARK 465     THR A   420                                                      
REMARK 465     PRO A   421                                                      
REMARK 465     GLY A   422                                                      
REMARK 465     ASN A   423                                                      
REMARK 465     SER A   424                                                      
REMARK 465     VAL A   425                                                      
REMARK 465     PRO A   426                                                      
REMARK 465     PRO A   427                                                      
REMARK 465     PRO A   428                                                      
REMARK 465     LEU A   429                                                      
REMARK 465     PRO A   430                                                      
REMARK 465     ARG A   431                                                      
REMARK 465     SER A   432                                                      
REMARK 465     ASN A   433                                                      
REMARK 465     SER A   434                                                      
REMARK 465     LEU A   435                                                      
REMARK 465     PRO A   436                                                      
REMARK 465     HIS A   437                                                      
REMARK 465     SER A   438                                                      
REMARK 465     ALA A   439                                                      
REMARK 465     VAL A   440                                                      
REMARK 465     SER A   441                                                      
REMARK 465     ASN A   442                                                      
REMARK 465     ALA A   443                                                      
REMARK 465     GLY A   444                                                      
REMARK 465     SER A   445                                                      
REMARK 465     LYS A   446                                                      
REMARK 465     SER A   447                                                      
REMARK 465     SER A   448                                                      
REMARK 465     VAL A   449                                                      
REMARK 465     MET A   450                                                      
REMARK 465     ASP A   451                                                      
REMARK 465     GLY A   452                                                      
REMARK 465     ALA A   453                                                      
REMARK 465     ILE A   454                                                      
REMARK 465     ALA A   455                                                      
REMARK 465     SER A   456                                                      
REMARK 465     GLY A   457                                                      
REMARK 465     VAL A   458                                                      
REMARK 465     SER A   459                                                      
REMARK 465     LYS A   460                                                      
REMARK 465     PHE A   461                                                      
REMARK 465     ALA A   462                                                      
REMARK 465     THR A   463                                                      
REMARK 465     LEU A   464                                                      
REMARK 465     SER A   465                                                      
REMARK 465     LEU A   466                                                      
REMARK 465     HIS A   467                                                      
REMARK 465     ASP A   468                                                      
REMARK 465     ARG A   469                                                      
REMARK 465     LYS A   470                                                      
REMARK 465     GLU A   471                                                      
REMARK 465     ARG A   472                                                      
REMARK 465     HIS A   473                                                      
REMARK 465     HIS A   474                                                      
REMARK 465     GLU A   475                                                      
REMARK 465     LYS A   476                                                      
REMARK 465     ASP A   477                                                      
REMARK 465     HIS A   478                                                      
REMARK 465     LYS A   479                                                      
REMARK 465     ARG A   480                                                      
REMARK 465     ASN A   481                                                      
REMARK 465     HIS A   482                                                      
REMARK 465     SER A   483                                                      
REMARK 465     MET A   484                                                      
REMARK 465     GLY A   485                                                      
REMARK 465     HIS A   486                                                      
REMARK 465     ILE A   487                                                      
REMARK 465     SER A   488                                                      
REMARK 465     SER A   489                                                      
REMARK 465     LYS A   490                                                      
REMARK 465     SER A   491                                                      
REMARK 465     SER A   492                                                      
REMARK 465     ASP A   493                                                      
REMARK 465     LYS A   494                                                      
REMARK 465     LEU A   495                                                      
REMARK 465     ASN A   496                                                      
REMARK 465     LEU A   497                                                      
REMARK 465     VAL A   498                                                      
REMARK 465     THR A   499                                                      
REMARK 465     LYS A   500                                                      
REMARK 465     THR A   501                                                      
REMARK 465     LYS A   502                                                      
REMARK 465     THR A   503                                                      
REMARK 465     ASP A   504                                                      
REMARK 465     PRO A   505                                                      
REMARK 465     ALA A   506                                                      
REMARK 465     LYS A   507                                                      
REMARK 465     THR A   508                                                      
REMARK 465     LEU A   509                                                      
REMARK 465     GLY A   510                                                      
REMARK 465     THR A   511                                                      
REMARK 465     PRO A   512                                                      
REMARK 465     LEU A   513                                                      
REMARK 465     CYS A   514                                                      
REMARK 465     PRO A   515                                                      
REMARK 465     ARG A   516                                                      
REMARK 465     MET A   517                                                      
REMARK 465     GLU A   518                                                      
REMARK 465     ASP A   519                                                      
REMARK 465     VAL A   564                                                      
REMARK 465     VAL A   565                                                      
REMARK 465     SER A   566                                                      
REMARK 465     PHE A   567                                                      
REMARK 465     ASN A   568                                                      
REMARK 465     PRO A   569                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     THR B     3                                                      
REMARK 465     GLU B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     GLY B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     LYS B     8                                                      
REMARK 465     GLU B     9                                                      
REMARK 465     MET B    10                                                      
REMARK 465     ASN B    11                                                      
REMARK 465     SER B   206                                                      
REMARK 465     LYS B   207                                                      
REMARK 465     SER B   208                                                      
REMARK 465     SER B   318                                                      
REMARK 465     VAL B   319                                                      
REMARK 465     GLU B   320                                                      
REMARK 465     GLU B   321                                                      
REMARK 465     GLY B   322                                                      
REMARK 465     ASP B   323                                                      
REMARK 465     PRO B   324                                                      
REMARK 465     MET B   325                                                      
REMARK 465     GLU B   326                                                      
REMARK 465     PHE B   327                                                      
REMARK 465     SER B   328                                                      
REMARK 465     GLY B   329                                                      
REMARK 465     SER B   330                                                      
REMARK 465     ASP B   331                                                      
REMARK 465     GLU B   332                                                      
REMARK 465     ASP B   333                                                      
REMARK 465     PHE B   334                                                      
REMARK 465     GLN B   335                                                      
REMARK 465     ASP B   336                                                      
REMARK 465     LEU B   337                                                      
REMARK 465     LEU B   338                                                      
REMARK 465     HIS B   339                                                      
REMARK 465     PHE B   340                                                      
REMARK 465     GLY B   341                                                      
REMARK 465     ARG B   342                                                      
REMARK 465     ASP B   343                                                      
REMARK 465     ARG B   344                                                      
REMARK 465     ALA B   345                                                      
REMARK 465     ASN B   346                                                      
REMARK 465     SER B   347                                                      
REMARK 465     THR B   348                                                      
REMARK 465     GLN B   349                                                      
REMARK 465     SER B   350                                                      
REMARK 465     ARG B   351                                                      
REMARK 465     LEU B   352                                                      
REMARK 465     SER B   353                                                      
REMARK 465     LYS B   354                                                      
REMARK 465     ARG B   355                                                      
REMARK 465     ASN B   356                                                      
REMARK 465     SER B   357                                                      
REMARK 465     THR B   358                                                      
REMARK 465     ASP B   359                                                      
REMARK 465     SER B   360                                                      
REMARK 465     ARG B   361                                                      
REMARK 465     PRO B   362                                                      
REMARK 465     VAL B   363                                                      
REMARK 465     SER B   364                                                      
REMARK 465     PRO B   390                                                      
REMARK 465     HIS B   391                                                      
REMARK 465     GLN B   392                                                      
REMARK 465     PRO B   393                                                      
REMARK 465     LEU B   394                                                      
REMARK 465     SER B   395                                                      
REMARK 465     ARG B   396                                                      
REMARK 465     ALA B   397                                                      
REMARK 465     ARG B   398                                                      
REMARK 465     THR B   399                                                      
REMARK 465     HIS B   400                                                      
REMARK 465     THR B   401                                                      
REMARK 465     ASN B   402                                                      
REMARK 465     VAL B   403                                                      
REMARK 465     MET B   404                                                      
REMARK 465     ASN B   405                                                      
REMARK 465     ALA B   406                                                      
REMARK 465     THR B   407                                                      
REMARK 465     SER B   408                                                      
REMARK 465     PRO B   409                                                      
REMARK 465     PRO B   410                                                      
REMARK 465     ALA B   411                                                      
REMARK 465     GLY B   412                                                      
REMARK 465     SER B   413                                                      
REMARK 465     ASN B   414                                                      
REMARK 465     GLY B   415                                                      
REMARK 465     ASN B   416                                                      
REMARK 465     SER B   417                                                      
REMARK 465     VAL B   418                                                      
REMARK 465     THR B   419                                                      
REMARK 465     THR B   420                                                      
REMARK 465     PRO B   421                                                      
REMARK 465     GLY B   422                                                      
REMARK 465     ASN B   423                                                      
REMARK 465     SER B   424                                                      
REMARK 465     VAL B   425                                                      
REMARK 465     PRO B   426                                                      
REMARK 465     PRO B   427                                                      
REMARK 465     PRO B   428                                                      
REMARK 465     LEU B   429                                                      
REMARK 465     PRO B   430                                                      
REMARK 465     ARG B   431                                                      
REMARK 465     SER B   432                                                      
REMARK 465     ASN B   433                                                      
REMARK 465     SER B   434                                                      
REMARK 465     LEU B   435                                                      
REMARK 465     PRO B   436                                                      
REMARK 465     HIS B   437                                                      
REMARK 465     SER B   438                                                      
REMARK 465     ALA B   439                                                      
REMARK 465     VAL B   440                                                      
REMARK 465     SER B   441                                                      
REMARK 465     ASN B   442                                                      
REMARK 465     ALA B   443                                                      
REMARK 465     GLY B   444                                                      
REMARK 465     SER B   445                                                      
REMARK 465     LYS B   446                                                      
REMARK 465     SER B   447                                                      
REMARK 465     SER B   448                                                      
REMARK 465     VAL B   449                                                      
REMARK 465     MET B   450                                                      
REMARK 465     ASP B   451                                                      
REMARK 465     GLY B   452                                                      
REMARK 465     ALA B   453                                                      
REMARK 465     ILE B   454                                                      
REMARK 465     ALA B   455                                                      
REMARK 465     SER B   456                                                      
REMARK 465     GLY B   457                                                      
REMARK 465     VAL B   458                                                      
REMARK 465     SER B   459                                                      
REMARK 465     LYS B   460                                                      
REMARK 465     PHE B   461                                                      
REMARK 465     ALA B   462                                                      
REMARK 465     THR B   463                                                      
REMARK 465     LEU B   464                                                      
REMARK 465     SER B   465                                                      
REMARK 465     LEU B   466                                                      
REMARK 465     HIS B   467                                                      
REMARK 465     ASP B   468                                                      
REMARK 465     ARG B   469                                                      
REMARK 465     LYS B   470                                                      
REMARK 465     GLU B   471                                                      
REMARK 465     ARG B   472                                                      
REMARK 465     HIS B   473                                                      
REMARK 465     HIS B   474                                                      
REMARK 465     GLU B   475                                                      
REMARK 465     LYS B   476                                                      
REMARK 465     ASP B   477                                                      
REMARK 465     HIS B   478                                                      
REMARK 465     LYS B   479                                                      
REMARK 465     ARG B   480                                                      
REMARK 465     ASN B   481                                                      
REMARK 465     HIS B   482                                                      
REMARK 465     SER B   483                                                      
REMARK 465     MET B   484                                                      
REMARK 465     GLY B   485                                                      
REMARK 465     HIS B   486                                                      
REMARK 465     ILE B   487                                                      
REMARK 465     SER B   488                                                      
REMARK 465     SER B   489                                                      
REMARK 465     LYS B   490                                                      
REMARK 465     SER B   491                                                      
REMARK 465     SER B   492                                                      
REMARK 465     ASP B   493                                                      
REMARK 465     LYS B   494                                                      
REMARK 465     LEU B   495                                                      
REMARK 465     ASN B   496                                                      
REMARK 465     LEU B   497                                                      
REMARK 465     VAL B   498                                                      
REMARK 465     THR B   499                                                      
REMARK 465     LYS B   500                                                      
REMARK 465     THR B   501                                                      
REMARK 465     LYS B   502                                                      
REMARK 465     THR B   503                                                      
REMARK 465     ASP B   504                                                      
REMARK 465     PRO B   505                                                      
REMARK 465     ALA B   506                                                      
REMARK 465     LYS B   507                                                      
REMARK 465     THR B   508                                                      
REMARK 465     LEU B   509                                                      
REMARK 465     GLY B   510                                                      
REMARK 465     THR B   511                                                      
REMARK 465     PRO B   512                                                      
REMARK 465     LEU B   513                                                      
REMARK 465     CYS B   514                                                      
REMARK 465     PRO B   515                                                      
REMARK 465     ARG B   516                                                      
REMARK 465     MET B   517                                                      
REMARK 465     GLU B   518                                                      
REMARK 465     VAL B   564                                                      
REMARK 465     VAL B   565                                                      
REMARK 465     SER B   566                                                      
REMARK 465     PHE B   567                                                      
REMARK 465     ASN B   568                                                      
REMARK 465     PRO B   569                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     GLU C     4                                                      
REMARK 465     GLY C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     GLY C     7                                                      
REMARK 465     LYS C     8                                                      
REMARK 465     GLU C     9                                                      
REMARK 465     MET C    10                                                      
REMARK 465     ASN C    11                                                      
REMARK 465     GLN C    43                                                      
REMARK 465     GLY C    44                                                      
REMARK 465     SER C    45                                                      
REMARK 465     ASP C    57                                                      
REMARK 465     GLN C    58                                                      
REMARK 465     SER C    59                                                      
REMARK 465     GLY C    60                                                      
REMARK 465     SER C   206                                                      
REMARK 465     LYS C   207                                                      
REMARK 465     SER C   208                                                      
REMARK 465     SER C   318                                                      
REMARK 465     VAL C   319                                                      
REMARK 465     GLU C   320                                                      
REMARK 465     GLU C   321                                                      
REMARK 465     GLY C   322                                                      
REMARK 465     ASP C   323                                                      
REMARK 465     PRO C   324                                                      
REMARK 465     MET C   325                                                      
REMARK 465     GLU C   326                                                      
REMARK 465     PHE C   327                                                      
REMARK 465     SER C   328                                                      
REMARK 465     GLY C   329                                                      
REMARK 465     SER C   330                                                      
REMARK 465     ASP C   331                                                      
REMARK 465     GLU C   332                                                      
REMARK 465     ASP C   333                                                      
REMARK 465     PHE C   334                                                      
REMARK 465     GLN C   335                                                      
REMARK 465     ASP C   336                                                      
REMARK 465     LEU C   337                                                      
REMARK 465     LEU C   338                                                      
REMARK 465     HIS C   339                                                      
REMARK 465     PHE C   340                                                      
REMARK 465     GLY C   341                                                      
REMARK 465     ARG C   342                                                      
REMARK 465     ASP C   343                                                      
REMARK 465     ARG C   344                                                      
REMARK 465     ALA C   345                                                      
REMARK 465     ASN C   346                                                      
REMARK 465     SER C   347                                                      
REMARK 465     THR C   348                                                      
REMARK 465     GLN C   349                                                      
REMARK 465     SER C   350                                                      
REMARK 465     ARG C   351                                                      
REMARK 465     LEU C   352                                                      
REMARK 465     SER C   353                                                      
REMARK 465     LYS C   354                                                      
REMARK 465     ARG C   355                                                      
REMARK 465     ASN C   356                                                      
REMARK 465     SER C   357                                                      
REMARK 465     THR C   358                                                      
REMARK 465     ASP C   359                                                      
REMARK 465     SER C   360                                                      
REMARK 465     ARG C   361                                                      
REMARK 465     PRO C   362                                                      
REMARK 465     VAL C   363                                                      
REMARK 465     SER C   364                                                      
REMARK 465     VAL C   365                                                      
REMARK 465     PRO C   390                                                      
REMARK 465     HIS C   391                                                      
REMARK 465     GLN C   392                                                      
REMARK 465     PRO C   393                                                      
REMARK 465     LEU C   394                                                      
REMARK 465     SER C   395                                                      
REMARK 465     ARG C   396                                                      
REMARK 465     ALA C   397                                                      
REMARK 465     ARG C   398                                                      
REMARK 465     THR C   399                                                      
REMARK 465     HIS C   400                                                      
REMARK 465     THR C   401                                                      
REMARK 465     ASN C   402                                                      
REMARK 465     VAL C   403                                                      
REMARK 465     MET C   404                                                      
REMARK 465     ASN C   405                                                      
REMARK 465     ALA C   406                                                      
REMARK 465     THR C   407                                                      
REMARK 465     SER C   408                                                      
REMARK 465     PRO C   409                                                      
REMARK 465     PRO C   410                                                      
REMARK 465     ALA C   411                                                      
REMARK 465     GLY C   412                                                      
REMARK 465     SER C   413                                                      
REMARK 465     ASN C   414                                                      
REMARK 465     GLY C   415                                                      
REMARK 465     ASN C   416                                                      
REMARK 465     SER C   417                                                      
REMARK 465     VAL C   418                                                      
REMARK 465     THR C   419                                                      
REMARK 465     THR C   420                                                      
REMARK 465     PRO C   421                                                      
REMARK 465     GLY C   422                                                      
REMARK 465     ASN C   423                                                      
REMARK 465     SER C   424                                                      
REMARK 465     VAL C   425                                                      
REMARK 465     PRO C   426                                                      
REMARK 465     PRO C   427                                                      
REMARK 465     PRO C   428                                                      
REMARK 465     LEU C   429                                                      
REMARK 465     PRO C   430                                                      
REMARK 465     ARG C   431                                                      
REMARK 465     SER C   432                                                      
REMARK 465     ASN C   433                                                      
REMARK 465     SER C   434                                                      
REMARK 465     LEU C   435                                                      
REMARK 465     PRO C   436                                                      
REMARK 465     HIS C   437                                                      
REMARK 465     SER C   438                                                      
REMARK 465     ALA C   439                                                      
REMARK 465     VAL C   440                                                      
REMARK 465     SER C   441                                                      
REMARK 465     ASN C   442                                                      
REMARK 465     ALA C   443                                                      
REMARK 465     GLY C   444                                                      
REMARK 465     SER C   445                                                      
REMARK 465     LYS C   446                                                      
REMARK 465     SER C   447                                                      
REMARK 465     SER C   448                                                      
REMARK 465     VAL C   449                                                      
REMARK 465     MET C   450                                                      
REMARK 465     ASP C   451                                                      
REMARK 465     GLY C   452                                                      
REMARK 465     ALA C   453                                                      
REMARK 465     ILE C   454                                                      
REMARK 465     ALA C   455                                                      
REMARK 465     SER C   456                                                      
REMARK 465     GLY C   457                                                      
REMARK 465     VAL C   458                                                      
REMARK 465     SER C   459                                                      
REMARK 465     LYS C   460                                                      
REMARK 465     PHE C   461                                                      
REMARK 465     ALA C   462                                                      
REMARK 465     THR C   463                                                      
REMARK 465     LEU C   464                                                      
REMARK 465     SER C   465                                                      
REMARK 465     LEU C   466                                                      
REMARK 465     HIS C   467                                                      
REMARK 465     ASP C   468                                                      
REMARK 465     ARG C   469                                                      
REMARK 465     LYS C   470                                                      
REMARK 465     GLU C   471                                                      
REMARK 465     ARG C   472                                                      
REMARK 465     HIS C   473                                                      
REMARK 465     HIS C   474                                                      
REMARK 465     GLU C   475                                                      
REMARK 465     LYS C   476                                                      
REMARK 465     ASP C   477                                                      
REMARK 465     HIS C   478                                                      
REMARK 465     LYS C   479                                                      
REMARK 465     ARG C   480                                                      
REMARK 465     ASN C   481                                                      
REMARK 465     HIS C   482                                                      
REMARK 465     SER C   483                                                      
REMARK 465     MET C   484                                                      
REMARK 465     GLY C   485                                                      
REMARK 465     HIS C   486                                                      
REMARK 465     ILE C   487                                                      
REMARK 465     SER C   488                                                      
REMARK 465     SER C   489                                                      
REMARK 465     LYS C   490                                                      
REMARK 465     SER C   491                                                      
REMARK 465     SER C   492                                                      
REMARK 465     ASP C   493                                                      
REMARK 465     LYS C   494                                                      
REMARK 465     LEU C   495                                                      
REMARK 465     ASN C   496                                                      
REMARK 465     LEU C   497                                                      
REMARK 465     VAL C   498                                                      
REMARK 465     THR C   499                                                      
REMARK 465     LYS C   500                                                      
REMARK 465     THR C   501                                                      
REMARK 465     LYS C   502                                                      
REMARK 465     THR C   503                                                      
REMARK 465     ASP C   504                                                      
REMARK 465     PRO C   505                                                      
REMARK 465     ALA C   506                                                      
REMARK 465     LYS C   507                                                      
REMARK 465     THR C   508                                                      
REMARK 465     LEU C   509                                                      
REMARK 465     GLY C   510                                                      
REMARK 465     THR C   511                                                      
REMARK 465     PRO C   512                                                      
REMARK 465     LEU C   513                                                      
REMARK 465     CYS C   514                                                      
REMARK 465     PRO C   515                                                      
REMARK 465     ARG C   516                                                      
REMARK 465     MET C   517                                                      
REMARK 465     GLU C   518                                                      
REMARK 465     ASP C   519                                                      
REMARK 465     GLY C   559                                                      
REMARK 465     ARG C   560                                                      
REMARK 465     PRO C   561                                                      
REMARK 465     GLY C   562                                                      
REMARK 465     LYS C   563                                                      
REMARK 465     VAL C   564                                                      
REMARK 465     VAL C   565                                                      
REMARK 465     SER C   566                                                      
REMARK 465     PHE C   567                                                      
REMARK 465     ASN C   568                                                      
REMARK 465     PRO C   569                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ASN A  11    CG   OD1  ND2                                       
REMARK 470     GLU A  12    CG   CD   OE1  OE2                                  
REMARK 470     ARG A  20    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A  37    NE   CZ   NH1  NH2                                  
REMARK 470     SER A  42    OG                                                  
REMARK 470     ASN A  56    CG   OD1  ND2                                       
REMARK 470     ASN A  61    CG   OD1  ND2                                       
REMARK 470     LYS A  97    CD   CE   NZ                                        
REMARK 470     GLU A 114    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 180    CD   OE1  OE2                                       
REMARK 470     THR A 185    OG1  CG2                                            
REMARK 470     GLU A 197    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 205    CG   CD   CE   NZ                                   
REMARK 470     THR A 209    OG1  CG2                                            
REMARK 470     ARG A 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 220    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 233    CG   CD   CE   NZ                                   
REMARK 470     ASP A 250    CG   OD1  OD2                                       
REMARK 470     ARG A 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 386    CG   OD1  OD2                                       
REMARK 470     ARG A 535    CZ   NH1  NH2                                       
REMARK 470     SER B  42    OG                                                  
REMARK 470     GLN B  43    CG   CD   OE1  NE2                                  
REMARK 470     ASN B  56    CG   OD1  ND2                                       
REMARK 470     GLN B  58    CG   CD   OE1  NE2                                  
REMARK 470     GLU B 114    CD   OE1  OE2                                       
REMARK 470     LYS B 139    CG   CD   CE   NZ                                   
REMARK 470     GLU B 144    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 180    CD   OE1  OE2                                       
REMARK 470     GLN B 191    CG   CD   OE1  NE2                                  
REMARK 470     LYS B 194    CD   CE   NZ                                        
REMARK 470     GLU B 197    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 205    CG   CD   CE   NZ                                   
REMARK 470     THR B 209    OG1  CG2                                            
REMARK 470     ARG B 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 220    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 233    CG   CD   CE   NZ                                   
REMARK 470     ASP B 250    CG   OD1  OD2                                       
REMARK 470     LYS B 259    CE   NZ                                             
REMARK 470     ARG B 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B 317    OG1  CG2                                            
REMARK 470     GLU B 385    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 386    CG   OD1  OD2                                       
REMARK 470     ILE B 387    CG1  CG2  CD1                                       
REMARK 470     ARG B 535    CZ   NH1  NH2                                       
REMARK 470     LYS B 563    CG   CD   CE   NZ                                   
REMARK 470     GLU C  12    CG   CD   OE1  OE2                                  
REMARK 470     LYS C  14    CG   CD   CE   NZ                                   
REMARK 470     GLN C  16    CG   CD   OE1  NE2                                  
REMARK 470     ARG C  20    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C  25    CG   CD   CE   NZ                                   
REMARK 470     LEU C  26    CG   CD1  CD2                                       
REMARK 470     ARG C  37    NE   CZ   NH1  NH2                                  
REMARK 470     SER C  42    OG                                                  
REMARK 470     LEU C  55    CG   CD1  CD2                                       
REMARK 470     ASN C  56    CG   OD1  ND2                                       
REMARK 470     ARG C  64    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL C  69    CG1  CG2                                            
REMARK 470     LYS C  79    CG   CD   CE   NZ                                   
REMARK 470     ARG C  82    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C  83    CG   CD   CE   NZ                                   
REMARK 470     LYS C  89    CG   CD   CE   NZ                                   
REMARK 470     LYS C  97    CG   CD   CE   NZ                                   
REMARK 470     GLU C 114    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 135    CG   CD   CE   NZ                                   
REMARK 470     GLU C 136    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 139    CG   CD   CE   NZ                                   
REMARK 470     LYS C 149    CG   CD   CE   NZ                                   
REMARK 470     GLU C 162    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 183    SG                                                  
REMARK 470     THR C 185    OG1  CG2                                            
REMARK 470     THR C 186    OG1  CG2                                            
REMARK 470     HIS C 189    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN C 191    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 194    CG   CD   CE   NZ                                   
REMARK 470     GLU C 197    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 205    CG   CD   CE   NZ                                   
REMARK 470     THR C 209    OG1  CG2                                            
REMARK 470     ARG C 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 220    CD   OE1  OE2                                       
REMARK 470     LYS C 233    CG   CD   CE   NZ                                   
REMARK 470     ASP C 250    CG   OD1  OD2                                       
REMARK 470     GLU C 253    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 275    CG   CD   CE   NZ                                   
REMARK 470     GLU C 282    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 304    CG   CD   CE   NZ                                   
REMARK 470     THR C 317    OG1  CG2                                            
REMARK 470     LEU C 383    CG   CD1  CD2                                       
REMARK 470     GLU C 385    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 386    CG   OD1  OD2                                       
REMARK 470     ILE C 387    CG1  CG2  CD1                                       
REMARK 470     GLU C 524    CG   CD   OE1  OE2                                  
REMARK 470     ILE C 527    CG1  CG2  CD1                                       
REMARK 470     LYS C 529    CG   CD   CE   NZ                                   
REMARK 470     ARG C 535    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 543    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 544    CG   OD1  OD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   ND2  ASN A    36     O    HOH A   701              1.89            
REMARK 500   OG   SER C   171     ND2  ASN C   173              2.05            
REMARK 500   N    GLY B   302     O    HOH B   701              2.06            
REMARK 500   O    GLY B    70     OE1  GLN B   100              2.16            
REMARK 500   O    GLY C    70     OE1  GLN C   100              2.17            
REMARK 500   OD2  ASP A   273     OH   TYR A   367              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    GLY B  60   N     GLY B  60   CA     -0.091                       
REMARK 500    GLY B  70   N     GLY B  70   CA     -0.134                       
REMARK 500    GLY C  70   N     GLY C  70   CA     -0.174                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ASN A 211   N   -  CA  -  C   ANGL. DEV. =  16.2 DEGREES          
REMARK 500    PRO A 212   C   -  N   -  CD  ANGL. DEV. =  12.9 DEGREES          
REMARK 500    ASN B  36   CA  -  C   -  N   ANGL. DEV. = -16.5 DEGREES          
REMARK 500    ASN B  36   O   -  C   -  N   ANGL. DEV. =  14.8 DEGREES          
REMARK 500    GLY B  60   O   -  C   -  N   ANGL. DEV. =  12.5 DEGREES          
REMARK 500    VAL B  69   CB  -  CA  -  C   ANGL. DEV. =  17.0 DEGREES          
REMARK 500    GLY B  70   O   -  C   -  N   ANGL. DEV. =  10.7 DEGREES          
REMARK 500    PRO B 212   C   -  N   -  CD  ANGL. DEV. =  12.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    VAL A  69      -72.48   -124.64                                   
REMARK 500    ILE A 133      -76.13    -92.13                                   
REMARK 500    CYS A 154      129.44   -174.11                                   
REMARK 500    CYS A 183     -135.03     81.23                                   
REMARK 500    VAL A 252       66.16     64.87                                   
REMARK 500    ASP A 284        7.37     81.77                                   
REMARK 500    SER A 305     -168.74   -166.33                                   
REMARK 500    ASP B  57      -58.05   -137.17                                   
REMARK 500    SER B  59       -2.84    -59.25                                   
REMARK 500    ASN B  61       46.18    -97.78                                   
REMARK 500    VAL B  69      -75.75    -94.78                                   
REMARK 500    ILE B 133      -63.25   -100.01                                   
REMARK 500    LEU B 193      -28.39   -145.31                                   
REMARK 500    SER B 305     -167.24   -170.25                                   
REMARK 500    THR B 316       42.37   -142.11                                   
REMARK 500    SER C  33     -176.38   -176.17                                   
REMARK 500    LEU C  55       33.97    -94.92                                   
REMARK 500    VAL C  69      -79.42   -104.02                                   
REMARK 500    SER C 138       78.81   -151.18                                   
REMARK 500    ASP C 148      132.40   -172.09                                   
REMARK 500    CYS C 154      127.17   -174.45                                   
REMARK 500    CYS C 183     -153.99   -135.28                                   
REMARK 500    LEU C 193      -67.60    -96.02                                   
REMARK 500    ASN C 211      -72.91    -65.90                                   
REMARK 500    PRO C 212       93.20    -57.26                                   
REMARK 500    SER C 305     -162.47   -164.46                                   
REMARK 500    CYS C 528       55.54   -158.59                                   
REMARK 500    GLU C 552       -7.08     85.16                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 THR A  182     CYS A  183                  136.69                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL A 602                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 B 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL B 602                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL B 603                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL B 604                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL C 601                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 5K1C   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5K1A   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5K1B   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5K16   RELATED DB: PDB                                   
DBREF  5K19 A    1   569  UNP    Q8TBZ3   WDR20_HUMAN      1    569             
DBREF  5K19 B    1   569  UNP    Q8TBZ3   WDR20_HUMAN      1    569             
DBREF  5K19 C    1   569  UNP    Q8TBZ3   WDR20_HUMAN      1    569             
SEQRES   1 A  569  MET ALA THR GLU GLY GLY GLY LYS GLU MET ASN GLU ILE          
SEQRES   2 A  569  LYS THR GLN PHE THR THR ARG GLU GLY LEU TYR LYS LEU          
SEQRES   3 A  569  LEU PRO HIS SER GLU TYR SER ARG PRO ASN ARG VAL PRO          
SEQRES   4 A  569  PHE ASN SER GLN GLY SER ASN PRO VAL ARG VAL SER PHE          
SEQRES   5 A  569  VAL ASN LEU ASN ASP GLN SER GLY ASN GLY ASP ARG LEU          
SEQRES   6 A  569  CYS PHE ASN VAL GLY ARG GLU LEU TYR PHE TYR ILE TYR          
SEQRES   7 A  569  LYS GLY VAL ARG LYS ALA ALA ASP LEU SER LYS PRO ILE          
SEQRES   8 A  569  ASP LYS ARG ILE TYR LYS GLY THR GLN PRO THR CYS HIS          
SEQRES   9 A  569  ASP PHE ASN HIS LEU THR ALA THR ALA GLU SER VAL SER          
SEQRES  10 A  569  LEU LEU VAL GLY PHE SER ALA GLY GLN VAL GLN LEU ILE          
SEQRES  11 A  569  ASP PRO ILE LYS LYS GLU THR SER LYS LEU PHE ASN GLU          
SEQRES  12 A  569  GLU ARG LEU ILE ASP LYS SER ARG VAL THR CYS VAL LYS          
SEQRES  13 A  569  TRP VAL PRO GLY SER GLU SER LEU PHE LEU VAL ALA HIS          
SEQRES  14 A  569  SER SER GLY ASN MET TYR LEU TYR ASN VAL GLU HIS THR          
SEQRES  15 A  569  CYS GLY THR THR ALA PRO HIS TYR GLN LEU LEU LYS GLN          
SEQRES  16 A  569  GLY GLU SER PHE ALA VAL HIS THR CYS LYS SER LYS SER          
SEQRES  17 A  569  THR ARG ASN PRO LEU LEU LYS TRP THR VAL GLY GLU GLY          
SEQRES  18 A  569  ALA LEU ASN GLU PHE ALA PHE SER PRO ASP GLY LYS PHE          
SEQRES  19 A  569  LEU ALA CYS VAL SER GLN ASP GLY PHE LEU ARG VAL PHE          
SEQRES  20 A  569  ASN PHE ASP SER VAL GLU LEU HIS GLY THR MET LYS SER          
SEQRES  21 A  569  TYR PHE GLY GLY LEU LEU CYS VAL CYS TRP SER PRO ASP          
SEQRES  22 A  569  GLY LYS TYR ILE VAL THR GLY GLY GLU ASP ASP LEU VAL          
SEQRES  23 A  569  THR VAL TRP SER PHE VAL ASP CYS ARG VAL ILE ALA ARG          
SEQRES  24 A  569  GLY HIS GLY HIS LYS SER TRP VAL SER VAL VAL ALA PHE          
SEQRES  25 A  569  ASP PRO TYR THR THR SER VAL GLU GLU GLY ASP PRO MET          
SEQRES  26 A  569  GLU PHE SER GLY SER ASP GLU ASP PHE GLN ASP LEU LEU          
SEQRES  27 A  569  HIS PHE GLY ARG ASP ARG ALA ASN SER THR GLN SER ARG          
SEQRES  28 A  569  LEU SER LYS ARG ASN SER THR ASP SER ARG PRO VAL SER          
SEQRES  29 A  569  VAL THR TYR ARG PHE GLY SER VAL GLY GLN ASP THR GLN          
SEQRES  30 A  569  LEU CYS LEU TRP ASP LEU THR GLU ASP ILE LEU PHE PRO          
SEQRES  31 A  569  HIS GLN PRO LEU SER ARG ALA ARG THR HIS THR ASN VAL          
SEQRES  32 A  569  MET ASN ALA THR SER PRO PRO ALA GLY SER ASN GLY ASN          
SEQRES  33 A  569  SER VAL THR THR PRO GLY ASN SER VAL PRO PRO PRO LEU          
SEQRES  34 A  569  PRO ARG SER ASN SER LEU PRO HIS SER ALA VAL SER ASN          
SEQRES  35 A  569  ALA GLY SER LYS SER SER VAL MET ASP GLY ALA ILE ALA          
SEQRES  36 A  569  SER GLY VAL SER LYS PHE ALA THR LEU SER LEU HIS ASP          
SEQRES  37 A  569  ARG LYS GLU ARG HIS HIS GLU LYS ASP HIS LYS ARG ASN          
SEQRES  38 A  569  HIS SER MET GLY HIS ILE SER SER LYS SER SER ASP LYS          
SEQRES  39 A  569  LEU ASN LEU VAL THR LYS THR LYS THR ASP PRO ALA LYS          
SEQRES  40 A  569  THR LEU GLY THR PRO LEU CYS PRO ARG MET GLU ASP VAL          
SEQRES  41 A  569  PRO LEU LEU GLU PRO LEU ILE CYS LYS LYS ILE ALA HIS          
SEQRES  42 A  569  GLU ARG LEU THR VAL LEU ILE PHE LEU GLU ASP CYS ILE          
SEQRES  43 A  569  VAL THR ALA CYS GLN GLU GLY PHE ILE CYS THR TRP GLY          
SEQRES  44 A  569  ARG PRO GLY LYS VAL VAL SER PHE ASN PRO                      
SEQRES   1 B  569  MET ALA THR GLU GLY GLY GLY LYS GLU MET ASN GLU ILE          
SEQRES   2 B  569  LYS THR GLN PHE THR THR ARG GLU GLY LEU TYR LYS LEU          
SEQRES   3 B  569  LEU PRO HIS SER GLU TYR SER ARG PRO ASN ARG VAL PRO          
SEQRES   4 B  569  PHE ASN SER GLN GLY SER ASN PRO VAL ARG VAL SER PHE          
SEQRES   5 B  569  VAL ASN LEU ASN ASP GLN SER GLY ASN GLY ASP ARG LEU          
SEQRES   6 B  569  CYS PHE ASN VAL GLY ARG GLU LEU TYR PHE TYR ILE TYR          
SEQRES   7 B  569  LYS GLY VAL ARG LYS ALA ALA ASP LEU SER LYS PRO ILE          
SEQRES   8 B  569  ASP LYS ARG ILE TYR LYS GLY THR GLN PRO THR CYS HIS          
SEQRES   9 B  569  ASP PHE ASN HIS LEU THR ALA THR ALA GLU SER VAL SER          
SEQRES  10 B  569  LEU LEU VAL GLY PHE SER ALA GLY GLN VAL GLN LEU ILE          
SEQRES  11 B  569  ASP PRO ILE LYS LYS GLU THR SER LYS LEU PHE ASN GLU          
SEQRES  12 B  569  GLU ARG LEU ILE ASP LYS SER ARG VAL THR CYS VAL LYS          
SEQRES  13 B  569  TRP VAL PRO GLY SER GLU SER LEU PHE LEU VAL ALA HIS          
SEQRES  14 B  569  SER SER GLY ASN MET TYR LEU TYR ASN VAL GLU HIS THR          
SEQRES  15 B  569  CYS GLY THR THR ALA PRO HIS TYR GLN LEU LEU LYS GLN          
SEQRES  16 B  569  GLY GLU SER PHE ALA VAL HIS THR CYS LYS SER LYS SER          
SEQRES  17 B  569  THR ARG ASN PRO LEU LEU LYS TRP THR VAL GLY GLU GLY          
SEQRES  18 B  569  ALA LEU ASN GLU PHE ALA PHE SER PRO ASP GLY LYS PHE          
SEQRES  19 B  569  LEU ALA CYS VAL SER GLN ASP GLY PHE LEU ARG VAL PHE          
SEQRES  20 B  569  ASN PHE ASP SER VAL GLU LEU HIS GLY THR MET LYS SER          
SEQRES  21 B  569  TYR PHE GLY GLY LEU LEU CYS VAL CYS TRP SER PRO ASP          
SEQRES  22 B  569  GLY LYS TYR ILE VAL THR GLY GLY GLU ASP ASP LEU VAL          
SEQRES  23 B  569  THR VAL TRP SER PHE VAL ASP CYS ARG VAL ILE ALA ARG          
SEQRES  24 B  569  GLY HIS GLY HIS LYS SER TRP VAL SER VAL VAL ALA PHE          
SEQRES  25 B  569  ASP PRO TYR THR THR SER VAL GLU GLU GLY ASP PRO MET          
SEQRES  26 B  569  GLU PHE SER GLY SER ASP GLU ASP PHE GLN ASP LEU LEU          
SEQRES  27 B  569  HIS PHE GLY ARG ASP ARG ALA ASN SER THR GLN SER ARG          
SEQRES  28 B  569  LEU SER LYS ARG ASN SER THR ASP SER ARG PRO VAL SER          
SEQRES  29 B  569  VAL THR TYR ARG PHE GLY SER VAL GLY GLN ASP THR GLN          
SEQRES  30 B  569  LEU CYS LEU TRP ASP LEU THR GLU ASP ILE LEU PHE PRO          
SEQRES  31 B  569  HIS GLN PRO LEU SER ARG ALA ARG THR HIS THR ASN VAL          
SEQRES  32 B  569  MET ASN ALA THR SER PRO PRO ALA GLY SER ASN GLY ASN          
SEQRES  33 B  569  SER VAL THR THR PRO GLY ASN SER VAL PRO PRO PRO LEU          
SEQRES  34 B  569  PRO ARG SER ASN SER LEU PRO HIS SER ALA VAL SER ASN          
SEQRES  35 B  569  ALA GLY SER LYS SER SER VAL MET ASP GLY ALA ILE ALA          
SEQRES  36 B  569  SER GLY VAL SER LYS PHE ALA THR LEU SER LEU HIS ASP          
SEQRES  37 B  569  ARG LYS GLU ARG HIS HIS GLU LYS ASP HIS LYS ARG ASN          
SEQRES  38 B  569  HIS SER MET GLY HIS ILE SER SER LYS SER SER ASP LYS          
SEQRES  39 B  569  LEU ASN LEU VAL THR LYS THR LYS THR ASP PRO ALA LYS          
SEQRES  40 B  569  THR LEU GLY THR PRO LEU CYS PRO ARG MET GLU ASP VAL          
SEQRES  41 B  569  PRO LEU LEU GLU PRO LEU ILE CYS LYS LYS ILE ALA HIS          
SEQRES  42 B  569  GLU ARG LEU THR VAL LEU ILE PHE LEU GLU ASP CYS ILE          
SEQRES  43 B  569  VAL THR ALA CYS GLN GLU GLY PHE ILE CYS THR TRP GLY          
SEQRES  44 B  569  ARG PRO GLY LYS VAL VAL SER PHE ASN PRO                      
SEQRES   1 C  569  MET ALA THR GLU GLY GLY GLY LYS GLU MET ASN GLU ILE          
SEQRES   2 C  569  LYS THR GLN PHE THR THR ARG GLU GLY LEU TYR LYS LEU          
SEQRES   3 C  569  LEU PRO HIS SER GLU TYR SER ARG PRO ASN ARG VAL PRO          
SEQRES   4 C  569  PHE ASN SER GLN GLY SER ASN PRO VAL ARG VAL SER PHE          
SEQRES   5 C  569  VAL ASN LEU ASN ASP GLN SER GLY ASN GLY ASP ARG LEU          
SEQRES   6 C  569  CYS PHE ASN VAL GLY ARG GLU LEU TYR PHE TYR ILE TYR          
SEQRES   7 C  569  LYS GLY VAL ARG LYS ALA ALA ASP LEU SER LYS PRO ILE          
SEQRES   8 C  569  ASP LYS ARG ILE TYR LYS GLY THR GLN PRO THR CYS HIS          
SEQRES   9 C  569  ASP PHE ASN HIS LEU THR ALA THR ALA GLU SER VAL SER          
SEQRES  10 C  569  LEU LEU VAL GLY PHE SER ALA GLY GLN VAL GLN LEU ILE          
SEQRES  11 C  569  ASP PRO ILE LYS LYS GLU THR SER LYS LEU PHE ASN GLU          
SEQRES  12 C  569  GLU ARG LEU ILE ASP LYS SER ARG VAL THR CYS VAL LYS          
SEQRES  13 C  569  TRP VAL PRO GLY SER GLU SER LEU PHE LEU VAL ALA HIS          
SEQRES  14 C  569  SER SER GLY ASN MET TYR LEU TYR ASN VAL GLU HIS THR          
SEQRES  15 C  569  CYS GLY THR THR ALA PRO HIS TYR GLN LEU LEU LYS GLN          
SEQRES  16 C  569  GLY GLU SER PHE ALA VAL HIS THR CYS LYS SER LYS SER          
SEQRES  17 C  569  THR ARG ASN PRO LEU LEU LYS TRP THR VAL GLY GLU GLY          
SEQRES  18 C  569  ALA LEU ASN GLU PHE ALA PHE SER PRO ASP GLY LYS PHE          
SEQRES  19 C  569  LEU ALA CYS VAL SER GLN ASP GLY PHE LEU ARG VAL PHE          
SEQRES  20 C  569  ASN PHE ASP SER VAL GLU LEU HIS GLY THR MET LYS SER          
SEQRES  21 C  569  TYR PHE GLY GLY LEU LEU CYS VAL CYS TRP SER PRO ASP          
SEQRES  22 C  569  GLY LYS TYR ILE VAL THR GLY GLY GLU ASP ASP LEU VAL          
SEQRES  23 C  569  THR VAL TRP SER PHE VAL ASP CYS ARG VAL ILE ALA ARG          
SEQRES  24 C  569  GLY HIS GLY HIS LYS SER TRP VAL SER VAL VAL ALA PHE          
SEQRES  25 C  569  ASP PRO TYR THR THR SER VAL GLU GLU GLY ASP PRO MET          
SEQRES  26 C  569  GLU PHE SER GLY SER ASP GLU ASP PHE GLN ASP LEU LEU          
SEQRES  27 C  569  HIS PHE GLY ARG ASP ARG ALA ASN SER THR GLN SER ARG          
SEQRES  28 C  569  LEU SER LYS ARG ASN SER THR ASP SER ARG PRO VAL SER          
SEQRES  29 C  569  VAL THR TYR ARG PHE GLY SER VAL GLY GLN ASP THR GLN          
SEQRES  30 C  569  LEU CYS LEU TRP ASP LEU THR GLU ASP ILE LEU PHE PRO          
SEQRES  31 C  569  HIS GLN PRO LEU SER ARG ALA ARG THR HIS THR ASN VAL          
SEQRES  32 C  569  MET ASN ALA THR SER PRO PRO ALA GLY SER ASN GLY ASN          
SEQRES  33 C  569  SER VAL THR THR PRO GLY ASN SER VAL PRO PRO PRO LEU          
SEQRES  34 C  569  PRO ARG SER ASN SER LEU PRO HIS SER ALA VAL SER ASN          
SEQRES  35 C  569  ALA GLY SER LYS SER SER VAL MET ASP GLY ALA ILE ALA          
SEQRES  36 C  569  SER GLY VAL SER LYS PHE ALA THR LEU SER LEU HIS ASP          
SEQRES  37 C  569  ARG LYS GLU ARG HIS HIS GLU LYS ASP HIS LYS ARG ASN          
SEQRES  38 C  569  HIS SER MET GLY HIS ILE SER SER LYS SER SER ASP LYS          
SEQRES  39 C  569  LEU ASN LEU VAL THR LYS THR LYS THR ASP PRO ALA LYS          
SEQRES  40 C  569  THR LEU GLY THR PRO LEU CYS PRO ARG MET GLU ASP VAL          
SEQRES  41 C  569  PRO LEU LEU GLU PRO LEU ILE CYS LYS LYS ILE ALA HIS          
SEQRES  42 C  569  GLU ARG LEU THR VAL LEU ILE PHE LEU GLU ASP CYS ILE          
SEQRES  43 C  569  VAL THR ALA CYS GLN GLU GLY PHE ILE CYS THR TRP GLY          
SEQRES  44 C  569  ARG PRO GLY LYS VAL VAL SER PHE ASN PRO                      
HET    SO4  A 601       5                                                       
HET    GOL  A 602       6                                                       
HET    SO4  B 601       5                                                       
HET    GOL  B 602       6                                                       
HET    GOL  B 603       6                                                       
HET    GOL  B 604       6                                                       
HET    GOL  C 601       6                                                       
HETNAM     SO4 SULFATE ION                                                      
HETNAM     GOL GLYCEROL                                                         
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL                                    
FORMUL   4  SO4    2(O4 S 2-)                                                   
FORMUL   5  GOL    5(C3 H8 O3)                                                  
FORMUL  11  HOH   *57(H2 O)                                                     
HELIX    1 AA1 PRO A   28  GLU A   31  5                                   4    
HELIX    2 AA2 GLU A  385  PHE A  389  1                                   5    
HELIX    3 AA3 PRO B  314  THR B  317  5                                   4    
HELIX    4 AA4 GLU B  385  PHE B  389  1                                   5    
HELIX    5 AA5 THR C  384  PHE C  389  1                                   6    
SHEET    1 AA1 5 GLN A  16  THR A  19  0                                        
SHEET    2 AA1 5 GLY A  22  LEU A  26 -1  O  GLY A  22   N  THR A  19           
SHEET    3 AA1 5 ILE A 555  GLY A 559 -1  O  GLY A 559   N  LYS A  25           
SHEET    4 AA1 5 CYS A 545  CYS A 550 -1  N  THR A 548   O  CYS A 556           
SHEET    5 AA1 5 LEU A 536  PHE A 541 -1  N  ILE A 540   O  VAL A 547           
SHEET    1 AA2 4 VAL A  50  ASN A  54  0                                        
SHEET    2 AA2 4 ASP A  63  ASN A  68 -1  O  ARG A  64   N  VAL A  53           
SHEET    3 AA2 4 GLU A  72  ILE A  77 -1  O  TYR A  74   N  PHE A  67           
SHEET    4 AA2 4 ASP A  92  ILE A  95 -1  O  ARG A  94   N  LEU A  73           
SHEET    1 AA3 4 PRO A 101  PHE A 106  0                                        
SHEET    2 AA3 4 LEU A 118  PHE A 122 -1  O  LEU A 119   N  ASP A 105           
SHEET    3 AA3 4 VAL A 127  ILE A 130 -1  O  GLN A 128   N  VAL A 120           
SHEET    4 AA3 4 SER A 138  PHE A 141 -1  O  LYS A 139   N  LEU A 129           
SHEET    1 AA4 6 VAL A 152  TRP A 157  0                                        
SHEET    2 AA4 6 LEU A 164  HIS A 169 -1  O  LEU A 166   N  LYS A 156           
SHEET    3 AA4 6 ASN A 173  ASN A 178 -1  O  TYR A 177   N  PHE A 165           
SHEET    4 AA4 6 PRO A 212  VAL A 218 -1  O  LEU A 213   N  LEU A 176           
SHEET    5 AA4 6 PHE A 199  CYS A 204 -1  N  HIS A 202   O  LYS A 215           
SHEET    6 AA4 6 TYR A 190  GLY A 196 -1  N  GLN A 191   O  THR A 203           
SHEET    1 AA5 4 LEU A 223  PHE A 228  0                                        
SHEET    2 AA5 4 PHE A 234  SER A 239 -1  O  ALA A 236   N  ALA A 227           
SHEET    3 AA5 4 PHE A 243  ASN A 248 -1  O  PHE A 247   N  LEU A 235           
SHEET    4 AA5 4 GLU A 253  LYS A 259 -1  O  MET A 258   N  LEU A 244           
SHEET    1 AA6 5 LEU A 265  TRP A 270  0                                        
SHEET    2 AA6 5 TYR A 276  GLY A 281 -1  O  VAL A 278   N  CYS A 269           
SHEET    3 AA6 5 VAL A 286  SER A 290 -1  O  THR A 287   N  THR A 279           
SHEET    4 AA6 5 VAL A 296  GLY A 300 -1  O  ILE A 297   N  VAL A 288           
SHEET    5 AA6 5 LEU A 522  LEU A 523  1  O  LEU A 523   N  ARG A 299           
SHEET    1 AA7 4 VAL A 307  PHE A 312  0                                        
SHEET    2 AA7 4 THR A 366  GLY A 373 -1  O  GLY A 370   N  ALA A 311           
SHEET    3 AA7 4 GLN A 377  THR A 384 -1  O  TRP A 381   N  PHE A 369           
SHEET    4 AA7 4 ILE A 527  LYS A 530 -1  O  LYS A 529   N  LEU A 378           
SHEET    1 AA8 5 GLN B  16  THR B  19  0                                        
SHEET    2 AA8 5 GLY B  22  LEU B  26 -1  O  TYR B  24   N  PHE B  17           
SHEET    3 AA8 5 ILE B 555  GLY B 559 -1  O  GLY B 559   N  LYS B  25           
SHEET    4 AA8 5 CYS B 545  CYS B 550 -1  N  THR B 548   O  CYS B 556           
SHEET    5 AA8 5 LEU B 536  PHE B 541 -1  N  ILE B 540   O  VAL B 547           
SHEET    1 AA9 4 VAL B  50  ASN B  54  0                                        
SHEET    2 AA9 4 ASP B  63  ASN B  68 -1  O  ARG B  64   N  VAL B  53           
SHEET    3 AA9 4 GLU B  72  ILE B  77 -1  O  TYR B  74   N  PHE B  67           
SHEET    4 AA9 4 ASP B  92  ILE B  95 -1  O  ARG B  94   N  LEU B  73           
SHEET    1 AB1 4 PRO B 101  PHE B 106  0                                        
SHEET    2 AB1 4 LEU B 118  PHE B 122 -1  O  LEU B 119   N  ASP B 105           
SHEET    3 AB1 4 VAL B 127  ILE B 130 -1  O  GLN B 128   N  VAL B 120           
SHEET    4 AB1 4 SER B 138  PHE B 141 -1  O  LYS B 139   N  LEU B 129           
SHEET    1 AB2 6 VAL B 152  TRP B 157  0                                        
SHEET    2 AB2 6 LEU B 164  HIS B 169 -1  O  LEU B 166   N  LYS B 156           
SHEET    3 AB2 6 ASN B 173  ASN B 178 -1  O  TYR B 177   N  PHE B 165           
SHEET    4 AB2 6 LEU B 214  VAL B 218 -1  O  TRP B 216   N  MET B 174           
SHEET    5 AB2 6 PHE B 199  CYS B 204 -1  N  HIS B 202   O  LYS B 215           
SHEET    6 AB2 6 TYR B 190  GLY B 196 -1  N  GLN B 191   O  THR B 203           
SHEET    1 AB3 4 LEU B 223  PHE B 228  0                                        
SHEET    2 AB3 4 PHE B 234  SER B 239 -1  O  VAL B 238   N  ASN B 224           
SHEET    3 AB3 4 PHE B 243  ASN B 248 -1  O  ARG B 245   N  CYS B 237           
SHEET    4 AB3 4 GLU B 253  LYS B 259 -1  O  HIS B 255   N  VAL B 246           
SHEET    1 AB4 5 LEU B 265  TRP B 270  0                                        
SHEET    2 AB4 5 TYR B 276  GLY B 281 -1  O  VAL B 278   N  CYS B 269           
SHEET    3 AB4 5 VAL B 286  SER B 290 -1  O  TRP B 289   N  ILE B 277           
SHEET    4 AB4 5 VAL B 296  GLY B 300 -1  O  ILE B 297   N  VAL B 288           
SHEET    5 AB4 5 LEU B 522  LEU B 523  1  O  LEU B 523   N  ARG B 299           
SHEET    1 AB5 4 VAL B 307  PHE B 312  0                                        
SHEET    2 AB5 4 THR B 366  GLY B 373 -1  O  GLY B 370   N  ALA B 311           
SHEET    3 AB5 4 GLN B 377  THR B 384 -1  O  TRP B 381   N  PHE B 369           
SHEET    4 AB5 4 ILE B 527  LYS B 530 -1  O  LYS B 529   N  LEU B 378           
SHEET    1 AB6 2 GLN C  16  THR C  19  0                                        
SHEET    2 AB6 2 GLY C  22  LYS C  25 -1  O  TYR C  24   N  PHE C  17           
SHEET    1 AB7 4 LEU C  27  TYR C  32  0                                        
SHEET    2 AB7 4 PHE C 554  TRP C 558 -1  O  ILE C 555   N  TYR C  32           
SHEET    3 AB7 4 ILE C 546  CYS C 550 -1  N  THR C 548   O  CYS C 556           
SHEET    4 AB7 4 LEU C 536  PHE C 541 -1  N  THR C 537   O  ALA C 549           
SHEET    1 AB8 4 VAL C  50  ASN C  54  0                                        
SHEET    2 AB8 4 ASP C  63  ASN C  68 -1  O  ARG C  64   N  VAL C  53           
SHEET    3 AB8 4 GLU C  72  ILE C  77 -1  O  TYR C  74   N  PHE C  67           
SHEET    4 AB8 4 ASP C  92  ILE C  95 -1  O  ARG C  94   N  LEU C  73           
SHEET    1 AB9 4 PRO C 101  PHE C 106  0                                        
SHEET    2 AB9 4 LEU C 118  PHE C 122 -1  O  GLY C 121   N  CYS C 103           
SHEET    3 AB9 4 VAL C 127  ILE C 130 -1  O  ILE C 130   N  LEU C 118           
SHEET    4 AB9 4 SER C 138  PHE C 141 -1  O  LYS C 139   N  LEU C 129           
SHEET    1 AC1 6 VAL C 152  TRP C 157  0                                        
SHEET    2 AC1 6 LEU C 164  HIS C 169 -1  O  ALA C 168   N  CYS C 154           
SHEET    3 AC1 6 ASN C 173  ASN C 178 -1  O  TYR C 177   N  PHE C 165           
SHEET    4 AC1 6 LEU C 214  VAL C 218 -1  O  TRP C 216   N  MET C 174           
SHEET    5 AC1 6 PHE C 199  CYS C 204 -1  N  HIS C 202   O  LYS C 215           
SHEET    6 AC1 6 TYR C 190  GLY C 196 -1  N  GLY C 196   O  PHE C 199           
SHEET    1 AC2 4 LEU C 223  PHE C 228  0                                        
SHEET    2 AC2 4 PHE C 234  SER C 239 -1  O  ALA C 236   N  ALA C 227           
SHEET    3 AC2 4 PHE C 243  ASN C 248 -1  O  PHE C 247   N  LEU C 235           
SHEET    4 AC2 4 GLU C 253  LYS C 259 -1  O  GLU C 253   N  ASN C 248           
SHEET    1 AC3 5 LEU C 265  TRP C 270  0                                        
SHEET    2 AC3 5 TYR C 276  GLY C 281 -1  O  GLY C 280   N  LEU C 266           
SHEET    3 AC3 5 VAL C 286  SER C 290 -1  O  TRP C 289   N  ILE C 277           
SHEET    4 AC3 5 ARG C 295  GLY C 300 -1  O  ILE C 297   N  VAL C 288           
SHEET    5 AC3 5 LEU C 522  LEU C 523  1  O  LEU C 523   N  ARG C 299           
SHEET    1 AC4 4 VAL C 307  ASP C 313  0                                        
SHEET    2 AC4 4 TYR C 367  GLY C 373 -1  O  GLY C 370   N  ALA C 311           
SHEET    3 AC4 4 GLN C 377  LEU C 383 -1  O  LEU C 383   N  TYR C 367           
SHEET    4 AC4 4 CYS C 528  LYS C 530 -1  O  LYS C 529   N  LEU C 378           
CISPEP   1 CYS A  183    GLY A  184          0       -11.66                     
SITE     1 AC1  2 ARG A 145  LYS A 149                                          
SITE     1 AC2  6 SER A 229  PRO A 230  ASP A 231  PHE A 234                    
SITE     2 AC2  6 GLY A 274  PHE A 291                                          
SITE     1 AC3  2 ARG B 151  SER B 170                                          
SITE     1 AC4  5 PHE A  17  THR A  18  LYS A 529  THR B  18                    
SITE     2 AC4  5 LYS B 529                                                     
SITE     1 AC5  3 ARG B 145  LYS B 149  HOH B 705                               
SITE     1 AC6  6 ARG B  49  CYS B 103  THR B 153  CYS B 154                    
SITE     2 AC6  6 ASN B 224  GLU B 225                                          
SITE     1 AC7  6 ILE C  95  GLN C 240  GLY C 263  GLY C 264                    
SITE     2 AC7  6 LEU C 266  GLU C 282                                          
CRYST1  120.014  120.014   95.307  90.00  90.00 120.00 P 31          9          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008332  0.004811  0.000000        0.00000                         
SCALE2      0.000000  0.009621  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.010492        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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