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Database: PDB
Entry: 5TBY
LinkDB: 5TBY
Original site: 5TBY 
HEADER    CONTRACTILE PROTEIN                     13-SEP-16   5TBY              
TITLE     HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED  
TITLE    2 BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM      
TITLE    3 APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA- 
TITLE    4 CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-    
TITLE    5 2240)                                                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: MYOSIN-7;                                                  
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 FRAGMENT: SUBFRAGMENT 1(S1);                                         
COMPND   5 SYNONYM: MYOSIN HEAVY CHAIN 7,MYOSIN HEAVY CHAIN SLOW ISOFORM,MYHC-  
COMPND   6 SLOW,MYOSIN HEAVY CHAIN,CARDIAC MUSCLE BETA ISOFORM,MYHC-BETA;       
COMPND   7 OTHER_DETAILS: MYOSIN 2 HEAVY CHAIN, VENTRICULAR CARDIAC MUSCLE, FREE
COMPND   8 HEAD HOMOLOGY MODEL OF HUMAN BETA CARDIAC HEAVY MEROMYOSIN           
COMPND   9 INTERACTING-HEADS MOTIF;                                             
COMPND  10 MOL_ID: 2;                                                           
COMPND  11 MOLECULE: MYOSIN LIGHT CHAIN 3;                                      
COMPND  12 CHAIN: C, D;                                                         
COMPND  13 SYNONYM: CARDIAC MYOSIN LIGHT CHAIN 1,CMLC1,MYOSIN LIGHT CHAIN 1,    
COMPND  14 SLOW-TWITCH MUSCLE B/VENTRICULAR ISOFORM,MLC1SB,VENTRICULAR MYOSIN   
COMPND  15 ALKALI LIGHT CHAIN,VENTRICULAR MYOSIN LIGHT CHAIN 1,VLCL,            
COMPND  16 VENTRICULAR/SLOW TWITCH MYOSIN ALKALI LIGHT CHAIN,MLC-LV/SB;         
COMPND  17 OTHER_DETAILS: MYOSIN 2 ESSENTIAL LIGHT CHAIN, VENTRICULAR CARDIAC   
COMPND  18 MUSCLE, FREE (CHAIN C) AND BLOCKED (CHAIN D) HEAD HOMOLOGY MODEL OF  
COMPND  19 HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF;         
COMPND  20 MOL_ID: 3;                                                           
COMPND  21 MOLECULE: MYOSIN REGULATORY LIGHT CHAIN 2, VENTRICULAR/CARDIAC MUSCLE
COMPND  22 ISOFORM;                                                             
COMPND  23 CHAIN: E, F;                                                         
COMPND  24 SYNONYM: MLC-2V,CARDIAC MYOSIN LIGHT CHAIN 2,MYOSIN LIGHT CHAIN 2,   
COMPND  25 SLOW SKELETAL/VENTRICULAR MUSCLE ISOFORM,MLC-2S/V,VENTRICULAR MYOSIN 
COMPND  26 LIGHT CHAIN 2;                                                       
COMPND  27 OTHER_DETAILS: MYOSIN 2 REGULATORY LIGHT CHAIN, VENTRICULAR CARDIAC  
COMPND  28 MUSCLE, FREE (CHAIN E) AND BLOCKED (CHAIN F) HEAD HOMOLOGY MODEL OF  
COMPND  29 HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF          
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606                                                 
KEYWDS    CONTRACTILE PROTEIN HYPERTROPHIC OR DILATED CARDIOMYOPATHY BETA-      
KEYWDS   2 CARDIAC MYOSIN II MYOSIN INTERACTING-HEADS MOTIF, CONTRACTILE        
KEYWDS   3 PROTEIN                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    L.ALAMO,J.S.WARE,A.PINTO,R.E.GILLILAN,J.G.SEIDMAN,C.E.SEIDMAN,        
AUTHOR   2 R.PADRON                                                             
REVDAT   9   08-JAN-20 5TBY    1       REMARK                                   
REVDAT   8   20-NOV-19 5TBY    1       REMARK                                   
REVDAT   7   03-OCT-18 5TBY    1       REMARK                                   
REVDAT   6   18-JUL-18 5TBY    1       REMARK                                   
REVDAT   5   08-NOV-17 5TBY    1       REMARK                                   
REVDAT   4   20-SEP-17 5TBY    1       REMARK                                   
REVDAT   3   09-AUG-17 5TBY    1       REMARK                                   
REVDAT   2   28-JUN-17 5TBY    1       JRNL                                     
REVDAT   1   07-JUN-17 5TBY    0                                                
JRNL        AUTH   L.ALAMO,J.S.WARE,A.PINTO,R.E.GILLILAN,J.G.SEIDMAN,           
JRNL        AUTH 2 C.E.SEIDMAN,R.PADRON                                         
JRNL        TITL   EFFECTS OF MYOSIN VARIANTS ON INTERACTING-HEADS MOTIF        
JRNL        TITL 2 EXPLAIN DISTINCT HYPERTROPHIC AND DILATED CARDIOMYOPATHY     
JRNL        TITL 3 PHENOTYPES.                                                  
JRNL        REF    ELIFE                         V.   6       2017              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   28606303                                                     
JRNL        DOI    10.7554/ELIFE.24634                                          
REMARK   0                                                                      
REMARK   0 THIS ENTRY REFLECTS AN ALTERNATIVE MODELING OF THE ORIGINAL DATA     
REMARK   0 IN 3JBH, DETERMINED BY ALAMO, L., QI, D., WRIGGERS, W., PINTO,       
REMARK   0 A., ZHU, J., BILBAO, A., GILLILAN, R.E., HU, S., PADRON, R.          
REMARK   0 ORIGINAL DATA REFERENCE 1                                            
REMARK   0  AUTH   L.ALAMO,D.QI,W.WRIGGERS,A.PINTO,J.ZHU,A.BILBAO,R.E.GILLILAN, 
REMARK   0  AUTH 2 S.HU,R.PADRON                                                
REMARK   0  TITL   CONSERVED INTRAMOLECULAR INTERACTIONS MAINTAIN MYOSIN        
REMARK   0  TITL 2 INTERACTING-HEADS MOTIFS EXPLAINING TARANTULA MUSCLE         
REMARK   0  TITL 3 SUPER-RELAXED STATE STRUCTURAL BASIS.                        
REMARK   0  REF    J. MOL. BIOL.                 V. 428  1142 2016              
REMARK   0  REFN                   ESSN 1089-8638                               
REMARK   0  PMID   26851071                                                     
REMARK   0  DOI    10.1016/J.JMB.2016.01.027                                    
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   L.ALAMO,W.WRIGGERS,A.PINTO,F.BARTOLI,L.SALAZAR,F.Q.ZHAO,     
REMARK   1  AUTH 2 R.CRAIG,R.PADRON                                             
REMARK   1  TITL   THREE-DIMENSIONAL RECONSTRUCTION OF TARANTULA MYOSIN         
REMARK   1  TITL 2 FILAMENTS SUGGESTS HOW PHOSPHORYLATION MAY REGULATE MYOSIN   
REMARK   1  TITL 3 ACTIVITY.                                                    
REMARK   1  REF    J. MOL. BIOL.                 V. 384   780 2008              
REMARK   1  REFN                   ESSN 1089-8638                               
REMARK   1  PMID   18951904                                                     
REMARK   1  DOI    10.1016/J.JMB.2008.10.013                                    
REMARK   1 REFERENCE 2                                                          
REMARK   1  AUTH   L.ALAMO,D.QI,W.WRIGGERS,A.PINTO,J.ZHU,A.BILBAO,R.E.GILLILAN, 
REMARK   1  AUTH 2 S.HU,R.PADRON                                                
REMARK   1  TITL   CONSERVED INTRAMOLECULAR INTERACTIONS MAINTAIN MYOSIN        
REMARK   1  TITL 2 INTERACTING-HEADS MOTIFS EXPLAINING TARANTULA MUSCLE         
REMARK   1  TITL 3 SUPER-RELAXED STATE STRUCTURAL BASIS.                        
REMARK   1  REF    J. MOL. BIOL.                 V. 428  1142 2016              
REMARK   1  REFN                   ESSN 1089-8638                               
REMARK   1  PMID   26851071                                                     
REMARK   1  DOI    10.1016/J.JMB.2016.01.027                                    
REMARK   1 REFERENCE 3                                                          
REMARK   1  AUTH   H.A.AL-KHAYAT,R.W.KENSLER,J.M.SQUIRE,S.B.MARSTON,E.P.MORRIS  
REMARK   1  TITL   ATOMIC MODEL OF THE HUMAN CARDIAC MUSCLE MYOSIN FILAMENT.    
REMARK   1  REF    PROC. NATL. ACAD. SCI.        V. 110   318 2013              
REMARK   1  REF  2 U.S.A.                                                       
REMARK   1  REFN                   ESSN 1091-6490                               
REMARK   1  PMID   23251030                                                     
REMARK   1  DOI    10.1073/PNAS.1212708110                                      
REMARK   1 REFERENCE 4                                                          
REMARK   1  AUTH   N.GUEX,M.C.PEITSCH                                           
REMARK   1  TITL   SWISS-MODEL AND THE SWISS-PDBVIEWER: AN ENVIRONMENT FOR      
REMARK   1  TITL 2 COMPARATIVE PROTEIN MODELING.                                
REMARK   1  REF    ELECTROPHORESIS               V.  18  2714 1997              
REMARK   1  REFN                   ISSN 0173-0835                               
REMARK   1  PMID   9504803                                                      
REMARK   1 REFERENCE 5                                                          
REMARK   1  AUTH   T.SCHWEDE,J.KOPP,N.GUEX,M.C.PEITSCH                          
REMARK   1  TITL   SWISS-MODEL: AN AUTOMATED PROTEIN HOMOLOGY-MODELING SERVER.  
REMARK   1  REF    NUCLEIC ACIDS RES.            V.  31  3381 2003              
REMARK   1  REFN                   ESSN 1362-4962                               
REMARK   1  PMID   12824332                                                     
REMARK   1 REFERENCE 6                                                          
REMARK   1  AUTH   K.ARNOLD,L.BORDOLI,J.KOPP,T.SCHWEDE                          
REMARK   1  TITL   THE SWISS-MODEL WORKSPACE: A WEB-BASED ENVIRONMENT FOR       
REMARK   1  TITL 2 PROTEIN STRUCTURE HOMOLOGY MODELLING.                        
REMARK   1  REF    BIOINFORMATICS                V.  22   195 2006              
REMARK   1  REFN                   ISSN 1367-4803                               
REMARK   1  PMID   16301204                                                     
REMARK   2                                                                      
REMARK   2 RESOLUTION.   20.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EMAN, UCSF CHIMERA, ITERATIVE HELICAL     
REMARK   3                            REAL SPACE RECONSTRUCTION (EGELMAN,       
REMARK   3                            2000)                                     
REMARK   3   RECONSTRUCTION SCHEMA  : BACK PROJECTION                           
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 3JBH                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : CORRELATION COEFFICIENT             
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 20.00                          
REMARK   3   NUMBER OF PARTICLES               : 10700                          
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: FOR PROJECTION MATCHING, GIVING A TOTAL OF 4,095      
REMARK   3  PROJECTIONS (13 TILTED PROJECTIONS PLUS-MINUS 12 DEG. EVERY         
REMARK   3  2DEG., 45 REFERENCE ROTATED PROJECTIONS (0-90 DEGREES, 2DEG.        
REMARK   3  ROTATION ANGLE), AND 7 IMAGE AXIAL SHIFTS OF 2.2 NM. THE            
REMARK   3  RESULTING 3D-MAP COMBINES ABOUT 10,700 OUT OF 15,504 FILAMENT       
REMARK   3  SEGMENTS, A YIELD OF 69 PERCENT OF INCLUDED SEGMENTS. THERE ARE     
REMARK   3  4 HELICES OF MYOSIN HEADS, ROTATED 30 DEGREES, EVERY 145            
REMARK   3  ANGSTROMS. THE FILAMENT SEGMENTS WERE SELECTED BASED ON VISUAL      
REMARK   3  JUDGEMENT OF GOOD HELICAL ORDER.                                    
REMARK   4                                                                      
REMARK   4 5TBY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-SEP-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000223769.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : FILAMENT                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : MYOSIN THICK FILAMENTS            
REMARK 245                                    TARANTULA STRIATED MUSCLE         
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : HOLEY CARBON GRIDS HAD BEEN       
REMARK 245                                    RENDERED HYDROPHILIC BY GLOW      
REMARK 245                                    DISCHARGE IN N-AMYLAMINE VAPOR    
REMARK 245                                    FOR 3 MINUTES BEFORE USE.         
REMARK 245   SAMPLE VITRIFICATION DETAILS   : PLUNGING IN A LIQUID ETHANE       
REMARK 245                                    COOLED BY LIQUID NITROGEN.        
REMARK 245                                    BLOTTING WAS PERFORMED FROM ONE   
REMARK 245                                    SIDE OF THE GRID TILL A THIN      
REMARK 245                                    SAMPLE FILM ON IT USING WHATMAN   
REMARK 245                                    NO. 42 FILTER PAPER, THEN THE     
REMARK 245                                    GRID WAS IMMEDIATELY PLUNGED      
REMARK 245                                    UNDER GRAVITY INTO LIQUID         
REMARK 245                                    ETHANE COOLED BY LIQUID           
REMARK 245                                    NITROGEN. GRIDS WERE STORED       
REMARK 245                                    UNDER LIQUID NITROGEN.            
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.00                              
REMARK 245   SAMPLE DETAILS                 : THE ATOMIC MODEL CONSIST OF ONE   
REMARK 245  INTERACTING-HEADS MOTIF, FORMED BY TWO HEAVY MEROMYOSIN (S1         
REMARK 245  MYOSIN HEAD WITH A SEGMENT OF S2 AND ESSENTIAL AND REGULATORY       
REMARK 245  LIGHT CHAINS) SO CALLED BLOCKED AND FREE HEADS, THE HOMOLOGY        
REMARK 245  MODEL IS BASED ON TARANTULA STRIATED MUSCLE MODEL STRUCTURE         
REMARK 245  3JBH. THIS MODEL WAS RIGIDLY DOCKED TO A TARANTULA 3D MAP (EMD-     
REMARK 245  1950) AND ALSO AGAINST HUMAN BETA-CARDIAC NEGATIVELY STAINED        
REMARK 245  THICK FILAMENT 2.8 NM RESOLUTION 3D-RECONSTRUCTION (EMD-2240)       
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 500                            
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI/PHILIPS CM120T             
REMARK 245   DETECTOR TYPE                     : KODAK SO-163 FILM              
REMARK 245   MINIMUM DEFOCUS (NM)              : 1950.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 1950.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 9.00                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 35000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 35000                          
REMARK 245   SOURCE                            : LAB6                           
REMARK 245   ACCELERATION VOLTAGE (KV)         : 120                            
REMARK 245   IMAGING DETAILS                   : HOLEY CARBON GRIDS             
REMARK 245  CRYOPRESERVED IN LIQUID ETHANE WERE OBSERVED IN A PHILIPS CM120     
REMARK 245  ELECTRON MICROSCOPE UNDER LOW DOSE CONDITIONS. ONLY FILAMENTS ON    
REMARK 245  THIN CARBON OVER HOLES WERE PHOTOGRAPHED                            
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 THE ASSEMBLY REPRESENTED IN THIS ENTRY HAS REGULAR                   
REMARK 300 HELICAL SYMMETRY WITH THE FOLLOWING PARAMETERS:                      
REMARK 300 ROTATION PER SUBUNIT (TWIST) = 30.00 DEGREES                         
REMARK 300 RISE PER SUBUNIT (HEIGHT) = 145.00 ANGSTROMS                         
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLY A     2                                                      
REMARK 465     ASP A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     GLU A     5                                                      
REMARK 465     THR A   960                                                      
REMARK 465     LEU A   961                                                      
REMARK 465     ALA A   962                                                      
REMARK 465     LYS A   963                                                      
REMARK 465     VAL A   964                                                      
REMARK 465     GLU A   965                                                      
REMARK 465     LYS A   966                                                      
REMARK 465     GLU A   967                                                      
REMARK 465     LYS A   968                                                      
REMARK 465     HIS A   969                                                      
REMARK 465     ALA A   970                                                      
REMARK 465     THR A   971                                                      
REMARK 465     GLU A   972                                                      
REMARK 465     ASN A   973                                                      
REMARK 465     LYS A   974                                                      
REMARK 465     VAL A   975                                                      
REMARK 465     LYS A   976                                                      
REMARK 465     ASN A   977                                                      
REMARK 465     LEU A   978                                                      
REMARK 465     THR A   979                                                      
REMARK 465     GLU A   980                                                      
REMARK 465     GLU A   981                                                      
REMARK 465     MET A   982                                                      
REMARK 465     ALA A   983                                                      
REMARK 465     GLY A   984                                                      
REMARK 465     LEU A   985                                                      
REMARK 465     ASP A   986                                                      
REMARK 465     GLU A   987                                                      
REMARK 465     ILE A   988                                                      
REMARK 465     ILE A   989                                                      
REMARK 465     ALA A   990                                                      
REMARK 465     LYS A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     THR A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLU A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     LYS A   997                                                      
REMARK 465     ALA A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     GLN A  1000                                                      
REMARK 465     GLU A  1001                                                      
REMARK 465     ALA A  1002                                                      
REMARK 465     HIS A  1003                                                      
REMARK 465     GLN A  1004                                                      
REMARK 465     GLN A  1005                                                      
REMARK 465     ALA A  1006                                                      
REMARK 465     LEU A  1007                                                      
REMARK 465     ASP A  1008                                                      
REMARK 465     ASP A  1009                                                      
REMARK 465     LEU A  1010                                                      
REMARK 465     GLN A  1011                                                      
REMARK 465     ALA A  1012                                                      
REMARK 465     GLU A  1013                                                      
REMARK 465     GLU A  1014                                                      
REMARK 465     ASP A  1015                                                      
REMARK 465     LYS A  1016                                                      
REMARK 465     VAL A  1017                                                      
REMARK 465     ASN A  1018                                                      
REMARK 465     THR A  1019                                                      
REMARK 465     LEU A  1020                                                      
REMARK 465     THR A  1021                                                      
REMARK 465     LYS A  1022                                                      
REMARK 465     ALA A  1023                                                      
REMARK 465     LYS A  1024                                                      
REMARK 465     VAL A  1025                                                      
REMARK 465     LYS A  1026                                                      
REMARK 465     LEU A  1027                                                      
REMARK 465     GLU A  1028                                                      
REMARK 465     GLN A  1029                                                      
REMARK 465     GLN A  1030                                                      
REMARK 465     VAL A  1031                                                      
REMARK 465     ASP A  1032                                                      
REMARK 465     ASP A  1033                                                      
REMARK 465     LEU A  1034                                                      
REMARK 465     GLU A  1035                                                      
REMARK 465     GLY A  1036                                                      
REMARK 465     SER A  1037                                                      
REMARK 465     LEU A  1038                                                      
REMARK 465     GLU A  1039                                                      
REMARK 465     GLN A  1040                                                      
REMARK 465     GLU A  1041                                                      
REMARK 465     LYS A  1042                                                      
REMARK 465     LYS A  1043                                                      
REMARK 465     VAL A  1044                                                      
REMARK 465     ARG A  1045                                                      
REMARK 465     MET A  1046                                                      
REMARK 465     ASP A  1047                                                      
REMARK 465     LEU A  1048                                                      
REMARK 465     GLU A  1049                                                      
REMARK 465     ARG A  1050                                                      
REMARK 465     ALA A  1051                                                      
REMARK 465     LYS A  1052                                                      
REMARK 465     ARG A  1053                                                      
REMARK 465     LYS A  1054                                                      
REMARK 465     LEU A  1055                                                      
REMARK 465     GLU A  1056                                                      
REMARK 465     GLY A  1057                                                      
REMARK 465     ASP A  1058                                                      
REMARK 465     LEU A  1059                                                      
REMARK 465     LYS A  1060                                                      
REMARK 465     LEU A  1061                                                      
REMARK 465     THR A  1062                                                      
REMARK 465     GLN A  1063                                                      
REMARK 465     GLU A  1064                                                      
REMARK 465     SER A  1065                                                      
REMARK 465     ILE A  1066                                                      
REMARK 465     MET A  1067                                                      
REMARK 465     ASP A  1068                                                      
REMARK 465     LEU A  1069                                                      
REMARK 465     GLU A  1070                                                      
REMARK 465     ASN A  1071                                                      
REMARK 465     ASP A  1072                                                      
REMARK 465     LYS A  1073                                                      
REMARK 465     GLN A  1074                                                      
REMARK 465     GLN A  1075                                                      
REMARK 465     LEU A  1076                                                      
REMARK 465     ASP A  1077                                                      
REMARK 465     GLU A  1078                                                      
REMARK 465     ARG A  1079                                                      
REMARK 465     LEU A  1080                                                      
REMARK 465     LYS A  1081                                                      
REMARK 465     LYS A  1082                                                      
REMARK 465     LYS A  1083                                                      
REMARK 465     ASP A  1084                                                      
REMARK 465     PHE A  1085                                                      
REMARK 465     GLU A  1086                                                      
REMARK 465     LEU A  1087                                                      
REMARK 465     ASN A  1088                                                      
REMARK 465     ALA A  1089                                                      
REMARK 465     LEU A  1090                                                      
REMARK 465     ASN A  1091                                                      
REMARK 465     ALA A  1092                                                      
REMARK 465     ARG A  1093                                                      
REMARK 465     ILE A  1094                                                      
REMARK 465     GLU A  1095                                                      
REMARK 465     ASP A  1096                                                      
REMARK 465     GLU A  1097                                                      
REMARK 465     GLN A  1098                                                      
REMARK 465     ALA A  1099                                                      
REMARK 465     LEU A  1100                                                      
REMARK 465     GLY A  1101                                                      
REMARK 465     SER A  1102                                                      
REMARK 465     GLN A  1103                                                      
REMARK 465     LEU A  1104                                                      
REMARK 465     GLN A  1105                                                      
REMARK 465     LYS A  1106                                                      
REMARK 465     LYS A  1107                                                      
REMARK 465     LEU A  1108                                                      
REMARK 465     LYS A  1109                                                      
REMARK 465     GLU A  1110                                                      
REMARK 465     LEU A  1111                                                      
REMARK 465     GLN A  1112                                                      
REMARK 465     ALA A  1113                                                      
REMARK 465     ARG A  1114                                                      
REMARK 465     ILE A  1115                                                      
REMARK 465     GLU A  1116                                                      
REMARK 465     GLU A  1117                                                      
REMARK 465     LEU A  1118                                                      
REMARK 465     GLU A  1119                                                      
REMARK 465     GLU A  1120                                                      
REMARK 465     GLU A  1121                                                      
REMARK 465     LEU A  1122                                                      
REMARK 465     GLU A  1123                                                      
REMARK 465     ALA A  1124                                                      
REMARK 465     GLU A  1125                                                      
REMARK 465     ARG A  1126                                                      
REMARK 465     THR A  1127                                                      
REMARK 465     ALA A  1128                                                      
REMARK 465     ARG A  1129                                                      
REMARK 465     ALA A  1130                                                      
REMARK 465     LYS A  1131                                                      
REMARK 465     VAL A  1132                                                      
REMARK 465     GLU A  1133                                                      
REMARK 465     LYS A  1134                                                      
REMARK 465     LEU A  1135                                                      
REMARK 465     ARG A  1136                                                      
REMARK 465     SER A  1137                                                      
REMARK 465     ASP A  1138                                                      
REMARK 465     LEU A  1139                                                      
REMARK 465     SER A  1140                                                      
REMARK 465     ARG A  1141                                                      
REMARK 465     GLU A  1142                                                      
REMARK 465     LEU A  1143                                                      
REMARK 465     GLU A  1144                                                      
REMARK 465     GLU A  1145                                                      
REMARK 465     ILE A  1146                                                      
REMARK 465     SER A  1147                                                      
REMARK 465     GLU A  1148                                                      
REMARK 465     ARG A  1149                                                      
REMARK 465     LEU A  1150                                                      
REMARK 465     GLU A  1151                                                      
REMARK 465     GLU A  1152                                                      
REMARK 465     ALA A  1153                                                      
REMARK 465     GLY A  1154                                                      
REMARK 465     GLY A  1155                                                      
REMARK 465     ALA A  1156                                                      
REMARK 465     THR A  1157                                                      
REMARK 465     SER A  1158                                                      
REMARK 465     VAL A  1159                                                      
REMARK 465     GLN A  1160                                                      
REMARK 465     ILE A  1161                                                      
REMARK 465     GLU A  1162                                                      
REMARK 465     MET A  1163                                                      
REMARK 465     ASN A  1164                                                      
REMARK 465     LYS A  1165                                                      
REMARK 465     LYS A  1166                                                      
REMARK 465     ARG A  1167                                                      
REMARK 465     GLU A  1168                                                      
REMARK 465     ALA A  1169                                                      
REMARK 465     GLU A  1170                                                      
REMARK 465     PHE A  1171                                                      
REMARK 465     GLN A  1172                                                      
REMARK 465     LYS A  1173                                                      
REMARK 465     MET A  1174                                                      
REMARK 465     ARG A  1175                                                      
REMARK 465     ARG A  1176                                                      
REMARK 465     ASP A  1177                                                      
REMARK 465     LEU A  1178                                                      
REMARK 465     GLU A  1179                                                      
REMARK 465     GLU A  1180                                                      
REMARK 465     ALA A  1181                                                      
REMARK 465     THR A  1182                                                      
REMARK 465     LEU A  1183                                                      
REMARK 465     GLN A  1184                                                      
REMARK 465     HIS A  1185                                                      
REMARK 465     GLU A  1186                                                      
REMARK 465     ALA A  1187                                                      
REMARK 465     THR A  1188                                                      
REMARK 465     ALA A  1189                                                      
REMARK 465     ALA A  1190                                                      
REMARK 465     ALA A  1191                                                      
REMARK 465     LEU A  1192                                                      
REMARK 465     ARG A  1193                                                      
REMARK 465     LYS A  1194                                                      
REMARK 465     LYS A  1195                                                      
REMARK 465     HIS A  1196                                                      
REMARK 465     ALA A  1197                                                      
REMARK 465     ASP A  1198                                                      
REMARK 465     SER A  1199                                                      
REMARK 465     VAL A  1200                                                      
REMARK 465     ALA A  1201                                                      
REMARK 465     GLU A  1202                                                      
REMARK 465     LEU A  1203                                                      
REMARK 465     GLY A  1204                                                      
REMARK 465     GLU A  1205                                                      
REMARK 465     GLN A  1206                                                      
REMARK 465     ILE A  1207                                                      
REMARK 465     ASP A  1208                                                      
REMARK 465     ASN A  1209                                                      
REMARK 465     LEU A  1210                                                      
REMARK 465     GLN A  1211                                                      
REMARK 465     ARG A  1212                                                      
REMARK 465     VAL A  1213                                                      
REMARK 465     LYS A  1214                                                      
REMARK 465     GLN A  1215                                                      
REMARK 465     LYS A  1216                                                      
REMARK 465     LEU A  1217                                                      
REMARK 465     GLU A  1218                                                      
REMARK 465     LYS A  1219                                                      
REMARK 465     GLU A  1220                                                      
REMARK 465     LYS A  1221                                                      
REMARK 465     SER A  1222                                                      
REMARK 465     GLU A  1223                                                      
REMARK 465     PHE A  1224                                                      
REMARK 465     LYS A  1225                                                      
REMARK 465     LEU A  1226                                                      
REMARK 465     GLU A  1227                                                      
REMARK 465     LEU A  1228                                                      
REMARK 465     ASP A  1229                                                      
REMARK 465     ASP A  1230                                                      
REMARK 465     VAL A  1231                                                      
REMARK 465     THR A  1232                                                      
REMARK 465     SER A  1233                                                      
REMARK 465     ASN A  1234                                                      
REMARK 465     MET A  1235                                                      
REMARK 465     GLU A  1236                                                      
REMARK 465     GLN A  1237                                                      
REMARK 465     ILE A  1238                                                      
REMARK 465     ILE A  1239                                                      
REMARK 465     LYS A  1240                                                      
REMARK 465     ALA A  1241                                                      
REMARK 465     LYS A  1242                                                      
REMARK 465     ALA A  1243                                                      
REMARK 465     ASN A  1244                                                      
REMARK 465     LEU A  1245                                                      
REMARK 465     GLU A  1246                                                      
REMARK 465     LYS A  1247                                                      
REMARK 465     MET A  1248                                                      
REMARK 465     CYS A  1249                                                      
REMARK 465     ARG A  1250                                                      
REMARK 465     THR A  1251                                                      
REMARK 465     LEU A  1252                                                      
REMARK 465     GLU A  1253                                                      
REMARK 465     ASP A  1254                                                      
REMARK 465     GLN A  1255                                                      
REMARK 465     MET A  1256                                                      
REMARK 465     ASN A  1257                                                      
REMARK 465     GLU A  1258                                                      
REMARK 465     HIS A  1259                                                      
REMARK 465     ARG A  1260                                                      
REMARK 465     SER A  1261                                                      
REMARK 465     LYS A  1262                                                      
REMARK 465     ALA A  1263                                                      
REMARK 465     GLU A  1264                                                      
REMARK 465     GLU A  1265                                                      
REMARK 465     THR A  1266                                                      
REMARK 465     GLN A  1267                                                      
REMARK 465     ARG A  1268                                                      
REMARK 465     SER A  1269                                                      
REMARK 465     VAL A  1270                                                      
REMARK 465     ASN A  1271                                                      
REMARK 465     ASP A  1272                                                      
REMARK 465     LEU A  1273                                                      
REMARK 465     THR A  1274                                                      
REMARK 465     SER A  1275                                                      
REMARK 465     GLN A  1276                                                      
REMARK 465     ARG A  1277                                                      
REMARK 465     ALA A  1278                                                      
REMARK 465     LYS A  1279                                                      
REMARK 465     LEU A  1280                                                      
REMARK 465     GLN A  1281                                                      
REMARK 465     THR A  1282                                                      
REMARK 465     GLU A  1283                                                      
REMARK 465     ASN A  1284                                                      
REMARK 465     GLY A  1285                                                      
REMARK 465     GLU A  1286                                                      
REMARK 465     LEU A  1287                                                      
REMARK 465     SER A  1288                                                      
REMARK 465     ARG A  1289                                                      
REMARK 465     GLN A  1290                                                      
REMARK 465     LEU A  1291                                                      
REMARK 465     ASP A  1292                                                      
REMARK 465     GLU A  1293                                                      
REMARK 465     LYS A  1294                                                      
REMARK 465     GLU A  1295                                                      
REMARK 465     ALA A  1296                                                      
REMARK 465     LEU A  1297                                                      
REMARK 465     ILE A  1298                                                      
REMARK 465     SER A  1299                                                      
REMARK 465     GLN A  1300                                                      
REMARK 465     LEU A  1301                                                      
REMARK 465     THR A  1302                                                      
REMARK 465     ARG A  1303                                                      
REMARK 465     GLY A  1304                                                      
REMARK 465     LYS A  1305                                                      
REMARK 465     LEU A  1306                                                      
REMARK 465     THR A  1307                                                      
REMARK 465     TYR A  1308                                                      
REMARK 465     THR A  1309                                                      
REMARK 465     GLN A  1310                                                      
REMARK 465     GLN A  1311                                                      
REMARK 465     LEU A  1312                                                      
REMARK 465     GLU A  1313                                                      
REMARK 465     ASP A  1314                                                      
REMARK 465     LEU A  1315                                                      
REMARK 465     LYS A  1316                                                      
REMARK 465     ARG A  1317                                                      
REMARK 465     GLN A  1318                                                      
REMARK 465     LEU A  1319                                                      
REMARK 465     GLU A  1320                                                      
REMARK 465     GLU A  1321                                                      
REMARK 465     GLU A  1322                                                      
REMARK 465     VAL A  1323                                                      
REMARK 465     LYS A  1324                                                      
REMARK 465     ALA A  1325                                                      
REMARK 465     LYS A  1326                                                      
REMARK 465     ASN A  1327                                                      
REMARK 465     ALA A  1328                                                      
REMARK 465     LEU A  1329                                                      
REMARK 465     ALA A  1330                                                      
REMARK 465     HIS A  1331                                                      
REMARK 465     ALA A  1332                                                      
REMARK 465     LEU A  1333                                                      
REMARK 465     GLN A  1334                                                      
REMARK 465     SER A  1335                                                      
REMARK 465     ALA A  1336                                                      
REMARK 465     ARG A  1337                                                      
REMARK 465     HIS A  1338                                                      
REMARK 465     ASP A  1339                                                      
REMARK 465     CYS A  1340                                                      
REMARK 465     ASP A  1341                                                      
REMARK 465     LEU A  1342                                                      
REMARK 465     LEU A  1343                                                      
REMARK 465     ARG A  1344                                                      
REMARK 465     GLU A  1345                                                      
REMARK 465     GLN A  1346                                                      
REMARK 465     TYR A  1347                                                      
REMARK 465     GLU A  1348                                                      
REMARK 465     GLU A  1349                                                      
REMARK 465     GLU A  1350                                                      
REMARK 465     THR A  1351                                                      
REMARK 465     GLU A  1352                                                      
REMARK 465     ALA A  1353                                                      
REMARK 465     LYS A  1354                                                      
REMARK 465     ALA A  1355                                                      
REMARK 465     GLU A  1356                                                      
REMARK 465     LEU A  1357                                                      
REMARK 465     GLN A  1358                                                      
REMARK 465     ARG A  1359                                                      
REMARK 465     VAL A  1360                                                      
REMARK 465     LEU A  1361                                                      
REMARK 465     SER A  1362                                                      
REMARK 465     LYS A  1363                                                      
REMARK 465     ALA A  1364                                                      
REMARK 465     ASN A  1365                                                      
REMARK 465     SER A  1366                                                      
REMARK 465     GLU A  1367                                                      
REMARK 465     VAL A  1368                                                      
REMARK 465     ALA A  1369                                                      
REMARK 465     GLN A  1370                                                      
REMARK 465     TRP A  1371                                                      
REMARK 465     ARG A  1372                                                      
REMARK 465     THR A  1373                                                      
REMARK 465     LYS A  1374                                                      
REMARK 465     TYR A  1375                                                      
REMARK 465     GLU A  1376                                                      
REMARK 465     THR A  1377                                                      
REMARK 465     ASP A  1378                                                      
REMARK 465     ALA A  1379                                                      
REMARK 465     ILE A  1380                                                      
REMARK 465     GLN A  1381                                                      
REMARK 465     ARG A  1382                                                      
REMARK 465     THR A  1383                                                      
REMARK 465     GLU A  1384                                                      
REMARK 465     GLU A  1385                                                      
REMARK 465     LEU A  1386                                                      
REMARK 465     GLU A  1387                                                      
REMARK 465     GLU A  1388                                                      
REMARK 465     ALA A  1389                                                      
REMARK 465     LYS A  1390                                                      
REMARK 465     LYS A  1391                                                      
REMARK 465     LYS A  1392                                                      
REMARK 465     LEU A  1393                                                      
REMARK 465     ALA A  1394                                                      
REMARK 465     GLN A  1395                                                      
REMARK 465     ARG A  1396                                                      
REMARK 465     LEU A  1397                                                      
REMARK 465     GLN A  1398                                                      
REMARK 465     GLU A  1399                                                      
REMARK 465     ALA A  1400                                                      
REMARK 465     GLU A  1401                                                      
REMARK 465     GLU A  1402                                                      
REMARK 465     ALA A  1403                                                      
REMARK 465     VAL A  1404                                                      
REMARK 465     GLU A  1405                                                      
REMARK 465     ALA A  1406                                                      
REMARK 465     VAL A  1407                                                      
REMARK 465     ASN A  1408                                                      
REMARK 465     ALA A  1409                                                      
REMARK 465     LYS A  1410                                                      
REMARK 465     CYS A  1411                                                      
REMARK 465     SER A  1412                                                      
REMARK 465     SER A  1413                                                      
REMARK 465     LEU A  1414                                                      
REMARK 465     GLU A  1415                                                      
REMARK 465     LYS A  1416                                                      
REMARK 465     THR A  1417                                                      
REMARK 465     LYS A  1418                                                      
REMARK 465     HIS A  1419                                                      
REMARK 465     ARG A  1420                                                      
REMARK 465     LEU A  1421                                                      
REMARK 465     GLN A  1422                                                      
REMARK 465     ASN A  1423                                                      
REMARK 465     GLU A  1424                                                      
REMARK 465     ILE A  1425                                                      
REMARK 465     GLU A  1426                                                      
REMARK 465     ASP A  1427                                                      
REMARK 465     LEU A  1428                                                      
REMARK 465     MET A  1429                                                      
REMARK 465     VAL A  1430                                                      
REMARK 465     ASP A  1431                                                      
REMARK 465     VAL A  1432                                                      
REMARK 465     GLU A  1433                                                      
REMARK 465     ARG A  1434                                                      
REMARK 465     SER A  1435                                                      
REMARK 465     ASN A  1436                                                      
REMARK 465     ALA A  1437                                                      
REMARK 465     ALA A  1438                                                      
REMARK 465     ALA A  1439                                                      
REMARK 465     ALA A  1440                                                      
REMARK 465     ALA A  1441                                                      
REMARK 465     LEU A  1442                                                      
REMARK 465     ASP A  1443                                                      
REMARK 465     LYS A  1444                                                      
REMARK 465     LYS A  1445                                                      
REMARK 465     GLN A  1446                                                      
REMARK 465     ARG A  1447                                                      
REMARK 465     ASN A  1448                                                      
REMARK 465     PHE A  1449                                                      
REMARK 465     ASP A  1450                                                      
REMARK 465     LYS A  1451                                                      
REMARK 465     ILE A  1452                                                      
REMARK 465     LEU A  1453                                                      
REMARK 465     ALA A  1454                                                      
REMARK 465     GLU A  1455                                                      
REMARK 465     TRP A  1456                                                      
REMARK 465     LYS A  1457                                                      
REMARK 465     GLN A  1458                                                      
REMARK 465     LYS A  1459                                                      
REMARK 465     TYR A  1460                                                      
REMARK 465     GLU A  1461                                                      
REMARK 465     GLU A  1462                                                      
REMARK 465     SER A  1463                                                      
REMARK 465     GLN A  1464                                                      
REMARK 465     SER A  1465                                                      
REMARK 465     GLU A  1466                                                      
REMARK 465     LEU A  1467                                                      
REMARK 465     GLU A  1468                                                      
REMARK 465     SER A  1469                                                      
REMARK 465     SER A  1470                                                      
REMARK 465     GLN A  1471                                                      
REMARK 465     LYS A  1472                                                      
REMARK 465     GLU A  1473                                                      
REMARK 465     ALA A  1474                                                      
REMARK 465     ARG A  1475                                                      
REMARK 465     SER A  1476                                                      
REMARK 465     LEU A  1477                                                      
REMARK 465     SER A  1478                                                      
REMARK 465     THR A  1479                                                      
REMARK 465     GLU A  1480                                                      
REMARK 465     LEU A  1481                                                      
REMARK 465     PHE A  1482                                                      
REMARK 465     LYS A  1483                                                      
REMARK 465     LEU A  1484                                                      
REMARK 465     LYS A  1485                                                      
REMARK 465     ASN A  1486                                                      
REMARK 465     ALA A  1487                                                      
REMARK 465     TYR A  1488                                                      
REMARK 465     GLU A  1489                                                      
REMARK 465     GLU A  1490                                                      
REMARK 465     SER A  1491                                                      
REMARK 465     LEU A  1492                                                      
REMARK 465     GLU A  1493                                                      
REMARK 465     HIS A  1494                                                      
REMARK 465     LEU A  1495                                                      
REMARK 465     GLU A  1496                                                      
REMARK 465     THR A  1497                                                      
REMARK 465     PHE A  1498                                                      
REMARK 465     LYS A  1499                                                      
REMARK 465     ARG A  1500                                                      
REMARK 465     GLU A  1501                                                      
REMARK 465     ASN A  1502                                                      
REMARK 465     LYS A  1503                                                      
REMARK 465     ASN A  1504                                                      
REMARK 465     LEU A  1505                                                      
REMARK 465     GLN A  1506                                                      
REMARK 465     GLU A  1507                                                      
REMARK 465     GLU A  1508                                                      
REMARK 465     ILE A  1509                                                      
REMARK 465     SER A  1510                                                      
REMARK 465     ASP A  1511                                                      
REMARK 465     LEU A  1512                                                      
REMARK 465     THR A  1513                                                      
REMARK 465     GLU A  1514                                                      
REMARK 465     GLN A  1515                                                      
REMARK 465     LEU A  1516                                                      
REMARK 465     GLY A  1517                                                      
REMARK 465     SER A  1518                                                      
REMARK 465     SER A  1519                                                      
REMARK 465     GLY A  1520                                                      
REMARK 465     LYS A  1521                                                      
REMARK 465     THR A  1522                                                      
REMARK 465     ILE A  1523                                                      
REMARK 465     HIS A  1524                                                      
REMARK 465     GLU A  1525                                                      
REMARK 465     LEU A  1526                                                      
REMARK 465     GLU A  1527                                                      
REMARK 465     LYS A  1528                                                      
REMARK 465     VAL A  1529                                                      
REMARK 465     ARG A  1530                                                      
REMARK 465     LYS A  1531                                                      
REMARK 465     GLN A  1532                                                      
REMARK 465     LEU A  1533                                                      
REMARK 465     GLU A  1534                                                      
REMARK 465     ALA A  1535                                                      
REMARK 465     GLU A  1536                                                      
REMARK 465     LYS A  1537                                                      
REMARK 465     MET A  1538                                                      
REMARK 465     GLU A  1539                                                      
REMARK 465     LEU A  1540                                                      
REMARK 465     GLN A  1541                                                      
REMARK 465     SER A  1542                                                      
REMARK 465     ALA A  1543                                                      
REMARK 465     LEU A  1544                                                      
REMARK 465     GLU A  1545                                                      
REMARK 465     GLU A  1546                                                      
REMARK 465     ALA A  1547                                                      
REMARK 465     GLU A  1548                                                      
REMARK 465     ALA A  1549                                                      
REMARK 465     SER A  1550                                                      
REMARK 465     LEU A  1551                                                      
REMARK 465     GLU A  1552                                                      
REMARK 465     HIS A  1553                                                      
REMARK 465     GLU A  1554                                                      
REMARK 465     GLU A  1555                                                      
REMARK 465     GLY A  1556                                                      
REMARK 465     LYS A  1557                                                      
REMARK 465     ILE A  1558                                                      
REMARK 465     LEU A  1559                                                      
REMARK 465     ARG A  1560                                                      
REMARK 465     ALA A  1561                                                      
REMARK 465     GLN A  1562                                                      
REMARK 465     LEU A  1563                                                      
REMARK 465     GLU A  1564                                                      
REMARK 465     PHE A  1565                                                      
REMARK 465     ASN A  1566                                                      
REMARK 465     GLN A  1567                                                      
REMARK 465     ILE A  1568                                                      
REMARK 465     LYS A  1569                                                      
REMARK 465     ALA A  1570                                                      
REMARK 465     GLU A  1571                                                      
REMARK 465     ILE A  1572                                                      
REMARK 465     GLU A  1573                                                      
REMARK 465     ARG A  1574                                                      
REMARK 465     LYS A  1575                                                      
REMARK 465     LEU A  1576                                                      
REMARK 465     ALA A  1577                                                      
REMARK 465     GLU A  1578                                                      
REMARK 465     LYS A  1579                                                      
REMARK 465     ASP A  1580                                                      
REMARK 465     GLU A  1581                                                      
REMARK 465     GLU A  1582                                                      
REMARK 465     MET A  1583                                                      
REMARK 465     GLU A  1584                                                      
REMARK 465     GLN A  1585                                                      
REMARK 465     ALA A  1586                                                      
REMARK 465     LYS A  1587                                                      
REMARK 465     ARG A  1588                                                      
REMARK 465     ASN A  1589                                                      
REMARK 465     HIS A  1590                                                      
REMARK 465     LEU A  1591                                                      
REMARK 465     ARG A  1592                                                      
REMARK 465     VAL A  1593                                                      
REMARK 465     VAL A  1594                                                      
REMARK 465     ASP A  1595                                                      
REMARK 465     SER A  1596                                                      
REMARK 465     LEU A  1597                                                      
REMARK 465     GLN A  1598                                                      
REMARK 465     THR A  1599                                                      
REMARK 465     SER A  1600                                                      
REMARK 465     LEU A  1601                                                      
REMARK 465     ASP A  1602                                                      
REMARK 465     ALA A  1603                                                      
REMARK 465     GLU A  1604                                                      
REMARK 465     THR A  1605                                                      
REMARK 465     ARG A  1606                                                      
REMARK 465     SER A  1607                                                      
REMARK 465     ARG A  1608                                                      
REMARK 465     ASN A  1609                                                      
REMARK 465     GLU A  1610                                                      
REMARK 465     ALA A  1611                                                      
REMARK 465     LEU A  1612                                                      
REMARK 465     ARG A  1613                                                      
REMARK 465     VAL A  1614                                                      
REMARK 465     LYS A  1615                                                      
REMARK 465     LYS A  1616                                                      
REMARK 465     LYS A  1617                                                      
REMARK 465     MET A  1618                                                      
REMARK 465     GLU A  1619                                                      
REMARK 465     GLY A  1620                                                      
REMARK 465     ASP A  1621                                                      
REMARK 465     LEU A  1622                                                      
REMARK 465     ASN A  1623                                                      
REMARK 465     GLU A  1624                                                      
REMARK 465     MET A  1625                                                      
REMARK 465     GLU A  1626                                                      
REMARK 465     ILE A  1627                                                      
REMARK 465     GLN A  1628                                                      
REMARK 465     LEU A  1629                                                      
REMARK 465     SER A  1630                                                      
REMARK 465     HIS A  1631                                                      
REMARK 465     ALA A  1632                                                      
REMARK 465     ASN A  1633                                                      
REMARK 465     ARG A  1634                                                      
REMARK 465     MET A  1635                                                      
REMARK 465     ALA A  1636                                                      
REMARK 465     ALA A  1637                                                      
REMARK 465     GLU A  1638                                                      
REMARK 465     ALA A  1639                                                      
REMARK 465     GLN A  1640                                                      
REMARK 465     LYS A  1641                                                      
REMARK 465     GLN A  1642                                                      
REMARK 465     VAL A  1643                                                      
REMARK 465     LYS A  1644                                                      
REMARK 465     SER A  1645                                                      
REMARK 465     LEU A  1646                                                      
REMARK 465     GLN A  1647                                                      
REMARK 465     SER A  1648                                                      
REMARK 465     LEU A  1649                                                      
REMARK 465     LEU A  1650                                                      
REMARK 465     LYS A  1651                                                      
REMARK 465     ASP A  1652                                                      
REMARK 465     THR A  1653                                                      
REMARK 465     GLN A  1654                                                      
REMARK 465     ILE A  1655                                                      
REMARK 465     GLN A  1656                                                      
REMARK 465     LEU A  1657                                                      
REMARK 465     ASP A  1658                                                      
REMARK 465     ASP A  1659                                                      
REMARK 465     ALA A  1660                                                      
REMARK 465     VAL A  1661                                                      
REMARK 465     ARG A  1662                                                      
REMARK 465     ALA A  1663                                                      
REMARK 465     ASN A  1664                                                      
REMARK 465     ASP A  1665                                                      
REMARK 465     ASP A  1666                                                      
REMARK 465     LEU A  1667                                                      
REMARK 465     LYS A  1668                                                      
REMARK 465     GLU A  1669                                                      
REMARK 465     ASN A  1670                                                      
REMARK 465     ILE A  1671                                                      
REMARK 465     ALA A  1672                                                      
REMARK 465     ILE A  1673                                                      
REMARK 465     VAL A  1674                                                      
REMARK 465     GLU A  1675                                                      
REMARK 465     ARG A  1676                                                      
REMARK 465     ARG A  1677                                                      
REMARK 465     ASN A  1678                                                      
REMARK 465     ASN A  1679                                                      
REMARK 465     LEU A  1680                                                      
REMARK 465     LEU A  1681                                                      
REMARK 465     GLN A  1682                                                      
REMARK 465     ALA A  1683                                                      
REMARK 465     GLU A  1684                                                      
REMARK 465     LEU A  1685                                                      
REMARK 465     GLU A  1686                                                      
REMARK 465     GLU A  1687                                                      
REMARK 465     LEU A  1688                                                      
REMARK 465     ARG A  1689                                                      
REMARK 465     ALA A  1690                                                      
REMARK 465     VAL A  1691                                                      
REMARK 465     VAL A  1692                                                      
REMARK 465     GLU A  1693                                                      
REMARK 465     GLN A  1694                                                      
REMARK 465     THR A  1695                                                      
REMARK 465     GLU A  1696                                                      
REMARK 465     ARG A  1697                                                      
REMARK 465     SER A  1698                                                      
REMARK 465     ARG A  1699                                                      
REMARK 465     LYS A  1700                                                      
REMARK 465     LEU A  1701                                                      
REMARK 465     ALA A  1702                                                      
REMARK 465     GLU A  1703                                                      
REMARK 465     GLN A  1704                                                      
REMARK 465     GLU A  1705                                                      
REMARK 465     LEU A  1706                                                      
REMARK 465     ILE A  1707                                                      
REMARK 465     GLU A  1708                                                      
REMARK 465     THR A  1709                                                      
REMARK 465     SER A  1710                                                      
REMARK 465     GLU A  1711                                                      
REMARK 465     ARG A  1712                                                      
REMARK 465     VAL A  1713                                                      
REMARK 465     GLN A  1714                                                      
REMARK 465     LEU A  1715                                                      
REMARK 465     LEU A  1716                                                      
REMARK 465     HIS A  1717                                                      
REMARK 465     SER A  1718                                                      
REMARK 465     GLN A  1719                                                      
REMARK 465     ASN A  1720                                                      
REMARK 465     THR A  1721                                                      
REMARK 465     SER A  1722                                                      
REMARK 465     LEU A  1723                                                      
REMARK 465     ILE A  1724                                                      
REMARK 465     ASN A  1725                                                      
REMARK 465     GLN A  1726                                                      
REMARK 465     LYS A  1727                                                      
REMARK 465     LYS A  1728                                                      
REMARK 465     LYS A  1729                                                      
REMARK 465     MET A  1730                                                      
REMARK 465     ASP A  1731                                                      
REMARK 465     ALA A  1732                                                      
REMARK 465     ASP A  1733                                                      
REMARK 465     LEU A  1734                                                      
REMARK 465     SER A  1735                                                      
REMARK 465     GLN A  1736                                                      
REMARK 465     LEU A  1737                                                      
REMARK 465     GLN A  1738                                                      
REMARK 465     THR A  1739                                                      
REMARK 465     GLU A  1740                                                      
REMARK 465     VAL A  1741                                                      
REMARK 465     GLU A  1742                                                      
REMARK 465     GLU A  1743                                                      
REMARK 465     ALA A  1744                                                      
REMARK 465     VAL A  1745                                                      
REMARK 465     GLN A  1746                                                      
REMARK 465     GLU A  1747                                                      
REMARK 465     CYS A  1748                                                      
REMARK 465     ARG A  1749                                                      
REMARK 465     ASN A  1750                                                      
REMARK 465     ALA A  1751                                                      
REMARK 465     GLU A  1752                                                      
REMARK 465     GLU A  1753                                                      
REMARK 465     LYS A  1754                                                      
REMARK 465     ALA A  1755                                                      
REMARK 465     LYS A  1756                                                      
REMARK 465     LYS A  1757                                                      
REMARK 465     ALA A  1758                                                      
REMARK 465     ILE A  1759                                                      
REMARK 465     THR A  1760                                                      
REMARK 465     ASP A  1761                                                      
REMARK 465     ALA A  1762                                                      
REMARK 465     ALA A  1763                                                      
REMARK 465     MET A  1764                                                      
REMARK 465     MET A  1765                                                      
REMARK 465     ALA A  1766                                                      
REMARK 465     GLU A  1767                                                      
REMARK 465     GLU A  1768                                                      
REMARK 465     LEU A  1769                                                      
REMARK 465     LYS A  1770                                                      
REMARK 465     LYS A  1771                                                      
REMARK 465     GLU A  1772                                                      
REMARK 465     GLN A  1773                                                      
REMARK 465     ASP A  1774                                                      
REMARK 465     THR A  1775                                                      
REMARK 465     SER A  1776                                                      
REMARK 465     ALA A  1777                                                      
REMARK 465     HIS A  1778                                                      
REMARK 465     LEU A  1779                                                      
REMARK 465     GLU A  1780                                                      
REMARK 465     ARG A  1781                                                      
REMARK 465     MET A  1782                                                      
REMARK 465     LYS A  1783                                                      
REMARK 465     LYS A  1784                                                      
REMARK 465     ASN A  1785                                                      
REMARK 465     MET A  1786                                                      
REMARK 465     GLU A  1787                                                      
REMARK 465     GLN A  1788                                                      
REMARK 465     THR A  1789                                                      
REMARK 465     ILE A  1790                                                      
REMARK 465     LYS A  1791                                                      
REMARK 465     ASP A  1792                                                      
REMARK 465     LEU A  1793                                                      
REMARK 465     GLN A  1794                                                      
REMARK 465     HIS A  1795                                                      
REMARK 465     ARG A  1796                                                      
REMARK 465     LEU A  1797                                                      
REMARK 465     ASP A  1798                                                      
REMARK 465     GLU A  1799                                                      
REMARK 465     ALA A  1800                                                      
REMARK 465     GLU A  1801                                                      
REMARK 465     GLN A  1802                                                      
REMARK 465     ILE A  1803                                                      
REMARK 465     ALA A  1804                                                      
REMARK 465     LEU A  1805                                                      
REMARK 465     LYS A  1806                                                      
REMARK 465     GLY A  1807                                                      
REMARK 465     GLY A  1808                                                      
REMARK 465     LYS A  1809                                                      
REMARK 465     LYS A  1810                                                      
REMARK 465     GLN A  1811                                                      
REMARK 465     LEU A  1812                                                      
REMARK 465     GLN A  1813                                                      
REMARK 465     LYS A  1814                                                      
REMARK 465     LEU A  1815                                                      
REMARK 465     GLU A  1816                                                      
REMARK 465     ALA A  1817                                                      
REMARK 465     ARG A  1818                                                      
REMARK 465     VAL A  1819                                                      
REMARK 465     ARG A  1820                                                      
REMARK 465     GLU A  1821                                                      
REMARK 465     LEU A  1822                                                      
REMARK 465     GLU A  1823                                                      
REMARK 465     ASN A  1824                                                      
REMARK 465     GLU A  1825                                                      
REMARK 465     LEU A  1826                                                      
REMARK 465     GLU A  1827                                                      
REMARK 465     ALA A  1828                                                      
REMARK 465     GLU A  1829                                                      
REMARK 465     GLN A  1830                                                      
REMARK 465     LYS A  1831                                                      
REMARK 465     ARG A  1832                                                      
REMARK 465     ASN A  1833                                                      
REMARK 465     ALA A  1834                                                      
REMARK 465     GLU A  1835                                                      
REMARK 465     SER A  1836                                                      
REMARK 465     VAL A  1837                                                      
REMARK 465     LYS A  1838                                                      
REMARK 465     GLY A  1839                                                      
REMARK 465     MET A  1840                                                      
REMARK 465     ARG A  1841                                                      
REMARK 465     LYS A  1842                                                      
REMARK 465     SER A  1843                                                      
REMARK 465     GLU A  1844                                                      
REMARK 465     ARG A  1845                                                      
REMARK 465     ARG A  1846                                                      
REMARK 465     ILE A  1847                                                      
REMARK 465     LYS A  1848                                                      
REMARK 465     GLU A  1849                                                      
REMARK 465     LEU A  1850                                                      
REMARK 465     THR A  1851                                                      
REMARK 465     TYR A  1852                                                      
REMARK 465     GLN A  1853                                                      
REMARK 465     THR A  1854                                                      
REMARK 465     GLU A  1855                                                      
REMARK 465     GLU A  1856                                                      
REMARK 465     ASP A  1857                                                      
REMARK 465     ARG A  1858                                                      
REMARK 465     LYS A  1859                                                      
REMARK 465     ASN A  1860                                                      
REMARK 465     LEU A  1861                                                      
REMARK 465     LEU A  1862                                                      
REMARK 465     ARG A  1863                                                      
REMARK 465     LEU A  1864                                                      
REMARK 465     GLN A  1865                                                      
REMARK 465     ASP A  1866                                                      
REMARK 465     LEU A  1867                                                      
REMARK 465     VAL A  1868                                                      
REMARK 465     ASP A  1869                                                      
REMARK 465     LYS A  1870                                                      
REMARK 465     LEU A  1871                                                      
REMARK 465     GLN A  1872                                                      
REMARK 465     LEU A  1873                                                      
REMARK 465     LYS A  1874                                                      
REMARK 465     VAL A  1875                                                      
REMARK 465     LYS A  1876                                                      
REMARK 465     ALA A  1877                                                      
REMARK 465     TYR A  1878                                                      
REMARK 465     LYS A  1879                                                      
REMARK 465     ARG A  1880                                                      
REMARK 465     GLN A  1881                                                      
REMARK 465     ALA A  1882                                                      
REMARK 465     GLU A  1883                                                      
REMARK 465     GLU A  1884                                                      
REMARK 465     ALA A  1885                                                      
REMARK 465     GLU A  1886                                                      
REMARK 465     GLU A  1887                                                      
REMARK 465     GLN A  1888                                                      
REMARK 465     ALA A  1889                                                      
REMARK 465     ASN A  1890                                                      
REMARK 465     THR A  1891                                                      
REMARK 465     ASN A  1892                                                      
REMARK 465     LEU A  1893                                                      
REMARK 465     SER A  1894                                                      
REMARK 465     LYS A  1895                                                      
REMARK 465     PHE A  1896                                                      
REMARK 465     ARG A  1897                                                      
REMARK 465     LYS A  1898                                                      
REMARK 465     VAL A  1899                                                      
REMARK 465     GLN A  1900                                                      
REMARK 465     HIS A  1901                                                      
REMARK 465     GLU A  1902                                                      
REMARK 465     LEU A  1903                                                      
REMARK 465     ASP A  1904                                                      
REMARK 465     GLU A  1905                                                      
REMARK 465     ALA A  1906                                                      
REMARK 465     GLU A  1907                                                      
REMARK 465     GLU A  1908                                                      
REMARK 465     ARG A  1909                                                      
REMARK 465     ALA A  1910                                                      
REMARK 465     ASP A  1911                                                      
REMARK 465     ILE A  1912                                                      
REMARK 465     ALA A  1913                                                      
REMARK 465     GLU A  1914                                                      
REMARK 465     SER A  1915                                                      
REMARK 465     GLN A  1916                                                      
REMARK 465     VAL A  1917                                                      
REMARK 465     ASN A  1918                                                      
REMARK 465     LYS A  1919                                                      
REMARK 465     LEU A  1920                                                      
REMARK 465     ARG A  1921                                                      
REMARK 465     ALA A  1922                                                      
REMARK 465     LYS A  1923                                                      
REMARK 465     SER A  1924                                                      
REMARK 465     ARG A  1925                                                      
REMARK 465     ASP A  1926                                                      
REMARK 465     ILE A  1927                                                      
REMARK 465     GLY A  1928                                                      
REMARK 465     THR A  1929                                                      
REMARK 465     LYS A  1930                                                      
REMARK 465     GLY A  1931                                                      
REMARK 465     LEU A  1932                                                      
REMARK 465     ASN A  1933                                                      
REMARK 465     GLU A  1934                                                      
REMARK 465     GLU A  1935                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     ASP B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     MET B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     VAL B     8                                                      
REMARK 465     PHE B     9                                                      
REMARK 465     THR B   960                                                      
REMARK 465     LEU B   961                                                      
REMARK 465     ALA B   962                                                      
REMARK 465     LYS B   963                                                      
REMARK 465     VAL B   964                                                      
REMARK 465     GLU B   965                                                      
REMARK 465     LYS B   966                                                      
REMARK 465     GLU B   967                                                      
REMARK 465     LYS B   968                                                      
REMARK 465     HIS B   969                                                      
REMARK 465     ALA B   970                                                      
REMARK 465     THR B   971                                                      
REMARK 465     GLU B   972                                                      
REMARK 465     ASN B   973                                                      
REMARK 465     LYS B   974                                                      
REMARK 465     VAL B   975                                                      
REMARK 465     LYS B   976                                                      
REMARK 465     ASN B   977                                                      
REMARK 465     LEU B   978                                                      
REMARK 465     THR B   979                                                      
REMARK 465     GLU B   980                                                      
REMARK 465     GLU B   981                                                      
REMARK 465     MET B   982                                                      
REMARK 465     ALA B   983                                                      
REMARK 465     GLY B   984                                                      
REMARK 465     LEU B   985                                                      
REMARK 465     ASP B   986                                                      
REMARK 465     GLU B   987                                                      
REMARK 465     ILE B   988                                                      
REMARK 465     ILE B   989                                                      
REMARK 465     ALA B   990                                                      
REMARK 465     LYS B   991                                                      
REMARK 465     LEU B   992                                                      
REMARK 465     THR B   993                                                      
REMARK 465     LYS B   994                                                      
REMARK 465     GLU B   995                                                      
REMARK 465     LYS B   996                                                      
REMARK 465     LYS B   997                                                      
REMARK 465     ALA B   998                                                      
REMARK 465     LEU B   999                                                      
REMARK 465     GLN B  1000                                                      
REMARK 465     GLU B  1001                                                      
REMARK 465     ALA B  1002                                                      
REMARK 465     HIS B  1003                                                      
REMARK 465     GLN B  1004                                                      
REMARK 465     GLN B  1005                                                      
REMARK 465     ALA B  1006                                                      
REMARK 465     LEU B  1007                                                      
REMARK 465     ASP B  1008                                                      
REMARK 465     ASP B  1009                                                      
REMARK 465     LEU B  1010                                                      
REMARK 465     GLN B  1011                                                      
REMARK 465     ALA B  1012                                                      
REMARK 465     GLU B  1013                                                      
REMARK 465     GLU B  1014                                                      
REMARK 465     ASP B  1015                                                      
REMARK 465     LYS B  1016                                                      
REMARK 465     VAL B  1017                                                      
REMARK 465     ASN B  1018                                                      
REMARK 465     THR B  1019                                                      
REMARK 465     LEU B  1020                                                      
REMARK 465     THR B  1021                                                      
REMARK 465     LYS B  1022                                                      
REMARK 465     ALA B  1023                                                      
REMARK 465     LYS B  1024                                                      
REMARK 465     VAL B  1025                                                      
REMARK 465     LYS B  1026                                                      
REMARK 465     LEU B  1027                                                      
REMARK 465     GLU B  1028                                                      
REMARK 465     GLN B  1029                                                      
REMARK 465     GLN B  1030                                                      
REMARK 465     VAL B  1031                                                      
REMARK 465     ASP B  1032                                                      
REMARK 465     ASP B  1033                                                      
REMARK 465     LEU B  1034                                                      
REMARK 465     GLU B  1035                                                      
REMARK 465     GLY B  1036                                                      
REMARK 465     SER B  1037                                                      
REMARK 465     LEU B  1038                                                      
REMARK 465     GLU B  1039                                                      
REMARK 465     GLN B  1040                                                      
REMARK 465     GLU B  1041                                                      
REMARK 465     LYS B  1042                                                      
REMARK 465     LYS B  1043                                                      
REMARK 465     VAL B  1044                                                      
REMARK 465     ARG B  1045                                                      
REMARK 465     MET B  1046                                                      
REMARK 465     ASP B  1047                                                      
REMARK 465     LEU B  1048                                                      
REMARK 465     GLU B  1049                                                      
REMARK 465     ARG B  1050                                                      
REMARK 465     ALA B  1051                                                      
REMARK 465     LYS B  1052                                                      
REMARK 465     ARG B  1053                                                      
REMARK 465     LYS B  1054                                                      
REMARK 465     LEU B  1055                                                      
REMARK 465     GLU B  1056                                                      
REMARK 465     GLY B  1057                                                      
REMARK 465     ASP B  1058                                                      
REMARK 465     LEU B  1059                                                      
REMARK 465     LYS B  1060                                                      
REMARK 465     LEU B  1061                                                      
REMARK 465     THR B  1062                                                      
REMARK 465     GLN B  1063                                                      
REMARK 465     GLU B  1064                                                      
REMARK 465     SER B  1065                                                      
REMARK 465     ILE B  1066                                                      
REMARK 465     MET B  1067                                                      
REMARK 465     ASP B  1068                                                      
REMARK 465     LEU B  1069                                                      
REMARK 465     GLU B  1070                                                      
REMARK 465     ASN B  1071                                                      
REMARK 465     ASP B  1072                                                      
REMARK 465     LYS B  1073                                                      
REMARK 465     GLN B  1074                                                      
REMARK 465     GLN B  1075                                                      
REMARK 465     LEU B  1076                                                      
REMARK 465     ASP B  1077                                                      
REMARK 465     GLU B  1078                                                      
REMARK 465     ARG B  1079                                                      
REMARK 465     LEU B  1080                                                      
REMARK 465     LYS B  1081                                                      
REMARK 465     LYS B  1082                                                      
REMARK 465     LYS B  1083                                                      
REMARK 465     ASP B  1084                                                      
REMARK 465     PHE B  1085                                                      
REMARK 465     GLU B  1086                                                      
REMARK 465     LEU B  1087                                                      
REMARK 465     ASN B  1088                                                      
REMARK 465     ALA B  1089                                                      
REMARK 465     LEU B  1090                                                      
REMARK 465     ASN B  1091                                                      
REMARK 465     ALA B  1092                                                      
REMARK 465     ARG B  1093                                                      
REMARK 465     ILE B  1094                                                      
REMARK 465     GLU B  1095                                                      
REMARK 465     ASP B  1096                                                      
REMARK 465     GLU B  1097                                                      
REMARK 465     GLN B  1098                                                      
REMARK 465     ALA B  1099                                                      
REMARK 465     LEU B  1100                                                      
REMARK 465     GLY B  1101                                                      
REMARK 465     SER B  1102                                                      
REMARK 465     GLN B  1103                                                      
REMARK 465     LEU B  1104                                                      
REMARK 465     GLN B  1105                                                      
REMARK 465     LYS B  1106                                                      
REMARK 465     LYS B  1107                                                      
REMARK 465     LEU B  1108                                                      
REMARK 465     LYS B  1109                                                      
REMARK 465     GLU B  1110                                                      
REMARK 465     LEU B  1111                                                      
REMARK 465     GLN B  1112                                                      
REMARK 465     ALA B  1113                                                      
REMARK 465     ARG B  1114                                                      
REMARK 465     ILE B  1115                                                      
REMARK 465     GLU B  1116                                                      
REMARK 465     GLU B  1117                                                      
REMARK 465     LEU B  1118                                                      
REMARK 465     GLU B  1119                                                      
REMARK 465     GLU B  1120                                                      
REMARK 465     GLU B  1121                                                      
REMARK 465     LEU B  1122                                                      
REMARK 465     GLU B  1123                                                      
REMARK 465     ALA B  1124                                                      
REMARK 465     GLU B  1125                                                      
REMARK 465     ARG B  1126                                                      
REMARK 465     THR B  1127                                                      
REMARK 465     ALA B  1128                                                      
REMARK 465     ARG B  1129                                                      
REMARK 465     ALA B  1130                                                      
REMARK 465     LYS B  1131                                                      
REMARK 465     VAL B  1132                                                      
REMARK 465     GLU B  1133                                                      
REMARK 465     LYS B  1134                                                      
REMARK 465     LEU B  1135                                                      
REMARK 465     ARG B  1136                                                      
REMARK 465     SER B  1137                                                      
REMARK 465     ASP B  1138                                                      
REMARK 465     LEU B  1139                                                      
REMARK 465     SER B  1140                                                      
REMARK 465     ARG B  1141                                                      
REMARK 465     GLU B  1142                                                      
REMARK 465     LEU B  1143                                                      
REMARK 465     GLU B  1144                                                      
REMARK 465     GLU B  1145                                                      
REMARK 465     ILE B  1146                                                      
REMARK 465     SER B  1147                                                      
REMARK 465     GLU B  1148                                                      
REMARK 465     ARG B  1149                                                      
REMARK 465     LEU B  1150                                                      
REMARK 465     GLU B  1151                                                      
REMARK 465     GLU B  1152                                                      
REMARK 465     ALA B  1153                                                      
REMARK 465     GLY B  1154                                                      
REMARK 465     GLY B  1155                                                      
REMARK 465     ALA B  1156                                                      
REMARK 465     THR B  1157                                                      
REMARK 465     SER B  1158                                                      
REMARK 465     VAL B  1159                                                      
REMARK 465     GLN B  1160                                                      
REMARK 465     ILE B  1161                                                      
REMARK 465     GLU B  1162                                                      
REMARK 465     MET B  1163                                                      
REMARK 465     ASN B  1164                                                      
REMARK 465     LYS B  1165                                                      
REMARK 465     LYS B  1166                                                      
REMARK 465     ARG B  1167                                                      
REMARK 465     GLU B  1168                                                      
REMARK 465     ALA B  1169                                                      
REMARK 465     GLU B  1170                                                      
REMARK 465     PHE B  1171                                                      
REMARK 465     GLN B  1172                                                      
REMARK 465     LYS B  1173                                                      
REMARK 465     MET B  1174                                                      
REMARK 465     ARG B  1175                                                      
REMARK 465     ARG B  1176                                                      
REMARK 465     ASP B  1177                                                      
REMARK 465     LEU B  1178                                                      
REMARK 465     GLU B  1179                                                      
REMARK 465     GLU B  1180                                                      
REMARK 465     ALA B  1181                                                      
REMARK 465     THR B  1182                                                      
REMARK 465     LEU B  1183                                                      
REMARK 465     GLN B  1184                                                      
REMARK 465     HIS B  1185                                                      
REMARK 465     GLU B  1186                                                      
REMARK 465     ALA B  1187                                                      
REMARK 465     THR B  1188                                                      
REMARK 465     ALA B  1189                                                      
REMARK 465     ALA B  1190                                                      
REMARK 465     ALA B  1191                                                      
REMARK 465     LEU B  1192                                                      
REMARK 465     ARG B  1193                                                      
REMARK 465     LYS B  1194                                                      
REMARK 465     LYS B  1195                                                      
REMARK 465     HIS B  1196                                                      
REMARK 465     ALA B  1197                                                      
REMARK 465     ASP B  1198                                                      
REMARK 465     SER B  1199                                                      
REMARK 465     VAL B  1200                                                      
REMARK 465     ALA B  1201                                                      
REMARK 465     GLU B  1202                                                      
REMARK 465     LEU B  1203                                                      
REMARK 465     GLY B  1204                                                      
REMARK 465     GLU B  1205                                                      
REMARK 465     GLN B  1206                                                      
REMARK 465     ILE B  1207                                                      
REMARK 465     ASP B  1208                                                      
REMARK 465     ASN B  1209                                                      
REMARK 465     LEU B  1210                                                      
REMARK 465     GLN B  1211                                                      
REMARK 465     ARG B  1212                                                      
REMARK 465     VAL B  1213                                                      
REMARK 465     LYS B  1214                                                      
REMARK 465     GLN B  1215                                                      
REMARK 465     LYS B  1216                                                      
REMARK 465     LEU B  1217                                                      
REMARK 465     GLU B  1218                                                      
REMARK 465     LYS B  1219                                                      
REMARK 465     GLU B  1220                                                      
REMARK 465     LYS B  1221                                                      
REMARK 465     SER B  1222                                                      
REMARK 465     GLU B  1223                                                      
REMARK 465     PHE B  1224                                                      
REMARK 465     LYS B  1225                                                      
REMARK 465     LEU B  1226                                                      
REMARK 465     GLU B  1227                                                      
REMARK 465     LEU B  1228                                                      
REMARK 465     ASP B  1229                                                      
REMARK 465     ASP B  1230                                                      
REMARK 465     VAL B  1231                                                      
REMARK 465     THR B  1232                                                      
REMARK 465     SER B  1233                                                      
REMARK 465     ASN B  1234                                                      
REMARK 465     MET B  1235                                                      
REMARK 465     GLU B  1236                                                      
REMARK 465     GLN B  1237                                                      
REMARK 465     ILE B  1238                                                      
REMARK 465     ILE B  1239                                                      
REMARK 465     LYS B  1240                                                      
REMARK 465     ALA B  1241                                                      
REMARK 465     LYS B  1242                                                      
REMARK 465     ALA B  1243                                                      
REMARK 465     ASN B  1244                                                      
REMARK 465     LEU B  1245                                                      
REMARK 465     GLU B  1246                                                      
REMARK 465     LYS B  1247                                                      
REMARK 465     MET B  1248                                                      
REMARK 465     CYS B  1249                                                      
REMARK 465     ARG B  1250                                                      
REMARK 465     THR B  1251                                                      
REMARK 465     LEU B  1252                                                      
REMARK 465     GLU B  1253                                                      
REMARK 465     ASP B  1254                                                      
REMARK 465     GLN B  1255                                                      
REMARK 465     MET B  1256                                                      
REMARK 465     ASN B  1257                                                      
REMARK 465     GLU B  1258                                                      
REMARK 465     HIS B  1259                                                      
REMARK 465     ARG B  1260                                                      
REMARK 465     SER B  1261                                                      
REMARK 465     LYS B  1262                                                      
REMARK 465     ALA B  1263                                                      
REMARK 465     GLU B  1264                                                      
REMARK 465     GLU B  1265                                                      
REMARK 465     THR B  1266                                                      
REMARK 465     GLN B  1267                                                      
REMARK 465     ARG B  1268                                                      
REMARK 465     SER B  1269                                                      
REMARK 465     VAL B  1270                                                      
REMARK 465     ASN B  1271                                                      
REMARK 465     ASP B  1272                                                      
REMARK 465     LEU B  1273                                                      
REMARK 465     THR B  1274                                                      
REMARK 465     SER B  1275                                                      
REMARK 465     GLN B  1276                                                      
REMARK 465     ARG B  1277                                                      
REMARK 465     ALA B  1278                                                      
REMARK 465     LYS B  1279                                                      
REMARK 465     LEU B  1280                                                      
REMARK 465     GLN B  1281                                                      
REMARK 465     THR B  1282                                                      
REMARK 465     GLU B  1283                                                      
REMARK 465     ASN B  1284                                                      
REMARK 465     GLY B  1285                                                      
REMARK 465     GLU B  1286                                                      
REMARK 465     LEU B  1287                                                      
REMARK 465     SER B  1288                                                      
REMARK 465     ARG B  1289                                                      
REMARK 465     GLN B  1290                                                      
REMARK 465     LEU B  1291                                                      
REMARK 465     ASP B  1292                                                      
REMARK 465     GLU B  1293                                                      
REMARK 465     LYS B  1294                                                      
REMARK 465     GLU B  1295                                                      
REMARK 465     ALA B  1296                                                      
REMARK 465     LEU B  1297                                                      
REMARK 465     ILE B  1298                                                      
REMARK 465     SER B  1299                                                      
REMARK 465     GLN B  1300                                                      
REMARK 465     LEU B  1301                                                      
REMARK 465     THR B  1302                                                      
REMARK 465     ARG B  1303                                                      
REMARK 465     GLY B  1304                                                      
REMARK 465     LYS B  1305                                                      
REMARK 465     LEU B  1306                                                      
REMARK 465     THR B  1307                                                      
REMARK 465     TYR B  1308                                                      
REMARK 465     THR B  1309                                                      
REMARK 465     GLN B  1310                                                      
REMARK 465     GLN B  1311                                                      
REMARK 465     LEU B  1312                                                      
REMARK 465     GLU B  1313                                                      
REMARK 465     ASP B  1314                                                      
REMARK 465     LEU B  1315                                                      
REMARK 465     LYS B  1316                                                      
REMARK 465     ARG B  1317                                                      
REMARK 465     GLN B  1318                                                      
REMARK 465     LEU B  1319                                                      
REMARK 465     GLU B  1320                                                      
REMARK 465     GLU B  1321                                                      
REMARK 465     GLU B  1322                                                      
REMARK 465     VAL B  1323                                                      
REMARK 465     LYS B  1324                                                      
REMARK 465     ALA B  1325                                                      
REMARK 465     LYS B  1326                                                      
REMARK 465     ASN B  1327                                                      
REMARK 465     ALA B  1328                                                      
REMARK 465     LEU B  1329                                                      
REMARK 465     ALA B  1330                                                      
REMARK 465     HIS B  1331                                                      
REMARK 465     ALA B  1332                                                      
REMARK 465     LEU B  1333                                                      
REMARK 465     GLN B  1334                                                      
REMARK 465     SER B  1335                                                      
REMARK 465     ALA B  1336                                                      
REMARK 465     ARG B  1337                                                      
REMARK 465     HIS B  1338                                                      
REMARK 465     ASP B  1339                                                      
REMARK 465     CYS B  1340                                                      
REMARK 465     ASP B  1341                                                      
REMARK 465     LEU B  1342                                                      
REMARK 465     LEU B  1343                                                      
REMARK 465     ARG B  1344                                                      
REMARK 465     GLU B  1345                                                      
REMARK 465     GLN B  1346                                                      
REMARK 465     TYR B  1347                                                      
REMARK 465     GLU B  1348                                                      
REMARK 465     GLU B  1349                                                      
REMARK 465     GLU B  1350                                                      
REMARK 465     THR B  1351                                                      
REMARK 465     GLU B  1352                                                      
REMARK 465     ALA B  1353                                                      
REMARK 465     LYS B  1354                                                      
REMARK 465     ALA B  1355                                                      
REMARK 465     GLU B  1356                                                      
REMARK 465     LEU B  1357                                                      
REMARK 465     GLN B  1358                                                      
REMARK 465     ARG B  1359                                                      
REMARK 465     VAL B  1360                                                      
REMARK 465     LEU B  1361                                                      
REMARK 465     SER B  1362                                                      
REMARK 465     LYS B  1363                                                      
REMARK 465     ALA B  1364                                                      
REMARK 465     ASN B  1365                                                      
REMARK 465     SER B  1366                                                      
REMARK 465     GLU B  1367                                                      
REMARK 465     VAL B  1368                                                      
REMARK 465     ALA B  1369                                                      
REMARK 465     GLN B  1370                                                      
REMARK 465     TRP B  1371                                                      
REMARK 465     ARG B  1372                                                      
REMARK 465     THR B  1373                                                      
REMARK 465     LYS B  1374                                                      
REMARK 465     TYR B  1375                                                      
REMARK 465     GLU B  1376                                                      
REMARK 465     THR B  1377                                                      
REMARK 465     ASP B  1378                                                      
REMARK 465     ALA B  1379                                                      
REMARK 465     ILE B  1380                                                      
REMARK 465     GLN B  1381                                                      
REMARK 465     ARG B  1382                                                      
REMARK 465     THR B  1383                                                      
REMARK 465     GLU B  1384                                                      
REMARK 465     GLU B  1385                                                      
REMARK 465     LEU B  1386                                                      
REMARK 465     GLU B  1387                                                      
REMARK 465     GLU B  1388                                                      
REMARK 465     ALA B  1389                                                      
REMARK 465     LYS B  1390                                                      
REMARK 465     LYS B  1391                                                      
REMARK 465     LYS B  1392                                                      
REMARK 465     LEU B  1393                                                      
REMARK 465     ALA B  1394                                                      
REMARK 465     GLN B  1395                                                      
REMARK 465     ARG B  1396                                                      
REMARK 465     LEU B  1397                                                      
REMARK 465     GLN B  1398                                                      
REMARK 465     GLU B  1399                                                      
REMARK 465     ALA B  1400                                                      
REMARK 465     GLU B  1401                                                      
REMARK 465     GLU B  1402                                                      
REMARK 465     ALA B  1403                                                      
REMARK 465     VAL B  1404                                                      
REMARK 465     GLU B  1405                                                      
REMARK 465     ALA B  1406                                                      
REMARK 465     VAL B  1407                                                      
REMARK 465     ASN B  1408                                                      
REMARK 465     ALA B  1409                                                      
REMARK 465     LYS B  1410                                                      
REMARK 465     CYS B  1411                                                      
REMARK 465     SER B  1412                                                      
REMARK 465     SER B  1413                                                      
REMARK 465     LEU B  1414                                                      
REMARK 465     GLU B  1415                                                      
REMARK 465     LYS B  1416                                                      
REMARK 465     THR B  1417                                                      
REMARK 465     LYS B  1418                                                      
REMARK 465     HIS B  1419                                                      
REMARK 465     ARG B  1420                                                      
REMARK 465     LEU B  1421                                                      
REMARK 465     GLN B  1422                                                      
REMARK 465     ASN B  1423                                                      
REMARK 465     GLU B  1424                                                      
REMARK 465     ILE B  1425                                                      
REMARK 465     GLU B  1426                                                      
REMARK 465     ASP B  1427                                                      
REMARK 465     LEU B  1428                                                      
REMARK 465     MET B  1429                                                      
REMARK 465     VAL B  1430                                                      
REMARK 465     ASP B  1431                                                      
REMARK 465     VAL B  1432                                                      
REMARK 465     GLU B  1433                                                      
REMARK 465     ARG B  1434                                                      
REMARK 465     SER B  1435                                                      
REMARK 465     ASN B  1436                                                      
REMARK 465     ALA B  1437                                                      
REMARK 465     ALA B  1438                                                      
REMARK 465     ALA B  1439                                                      
REMARK 465     ALA B  1440                                                      
REMARK 465     ALA B  1441                                                      
REMARK 465     LEU B  1442                                                      
REMARK 465     ASP B  1443                                                      
REMARK 465     LYS B  1444                                                      
REMARK 465     LYS B  1445                                                      
REMARK 465     GLN B  1446                                                      
REMARK 465     ARG B  1447                                                      
REMARK 465     ASN B  1448                                                      
REMARK 465     PHE B  1449                                                      
REMARK 465     ASP B  1450                                                      
REMARK 465     LYS B  1451                                                      
REMARK 465     ILE B  1452                                                      
REMARK 465     LEU B  1453                                                      
REMARK 465     ALA B  1454                                                      
REMARK 465     GLU B  1455                                                      
REMARK 465     TRP B  1456                                                      
REMARK 465     LYS B  1457                                                      
REMARK 465     GLN B  1458                                                      
REMARK 465     LYS B  1459                                                      
REMARK 465     TYR B  1460                                                      
REMARK 465     GLU B  1461                                                      
REMARK 465     GLU B  1462                                                      
REMARK 465     SER B  1463                                                      
REMARK 465     GLN B  1464                                                      
REMARK 465     SER B  1465                                                      
REMARK 465     GLU B  1466                                                      
REMARK 465     LEU B  1467                                                      
REMARK 465     GLU B  1468                                                      
REMARK 465     SER B  1469                                                      
REMARK 465     SER B  1470                                                      
REMARK 465     GLN B  1471                                                      
REMARK 465     LYS B  1472                                                      
REMARK 465     GLU B  1473                                                      
REMARK 465     ALA B  1474                                                      
REMARK 465     ARG B  1475                                                      
REMARK 465     SER B  1476                                                      
REMARK 465     LEU B  1477                                                      
REMARK 465     SER B  1478                                                      
REMARK 465     THR B  1479                                                      
REMARK 465     GLU B  1480                                                      
REMARK 465     LEU B  1481                                                      
REMARK 465     PHE B  1482                                                      
REMARK 465     LYS B  1483                                                      
REMARK 465     LEU B  1484                                                      
REMARK 465     LYS B  1485                                                      
REMARK 465     ASN B  1486                                                      
REMARK 465     ALA B  1487                                                      
REMARK 465     TYR B  1488                                                      
REMARK 465     GLU B  1489                                                      
REMARK 465     GLU B  1490                                                      
REMARK 465     SER B  1491                                                      
REMARK 465     LEU B  1492                                                      
REMARK 465     GLU B  1493                                                      
REMARK 465     HIS B  1494                                                      
REMARK 465     LEU B  1495                                                      
REMARK 465     GLU B  1496                                                      
REMARK 465     THR B  1497                                                      
REMARK 465     PHE B  1498                                                      
REMARK 465     LYS B  1499                                                      
REMARK 465     ARG B  1500                                                      
REMARK 465     GLU B  1501                                                      
REMARK 465     ASN B  1502                                                      
REMARK 465     LYS B  1503                                                      
REMARK 465     ASN B  1504                                                      
REMARK 465     LEU B  1505                                                      
REMARK 465     GLN B  1506                                                      
REMARK 465     GLU B  1507                                                      
REMARK 465     GLU B  1508                                                      
REMARK 465     ILE B  1509                                                      
REMARK 465     SER B  1510                                                      
REMARK 465     ASP B  1511                                                      
REMARK 465     LEU B  1512                                                      
REMARK 465     THR B  1513                                                      
REMARK 465     GLU B  1514                                                      
REMARK 465     GLN B  1515                                                      
REMARK 465     LEU B  1516                                                      
REMARK 465     GLY B  1517                                                      
REMARK 465     SER B  1518                                                      
REMARK 465     SER B  1519                                                      
REMARK 465     GLY B  1520                                                      
REMARK 465     LYS B  1521                                                      
REMARK 465     THR B  1522                                                      
REMARK 465     ILE B  1523                                                      
REMARK 465     HIS B  1524                                                      
REMARK 465     GLU B  1525                                                      
REMARK 465     LEU B  1526                                                      
REMARK 465     GLU B  1527                                                      
REMARK 465     LYS B  1528                                                      
REMARK 465     VAL B  1529                                                      
REMARK 465     ARG B  1530                                                      
REMARK 465     LYS B  1531                                                      
REMARK 465     GLN B  1532                                                      
REMARK 465     LEU B  1533                                                      
REMARK 465     GLU B  1534                                                      
REMARK 465     ALA B  1535                                                      
REMARK 465     GLU B  1536                                                      
REMARK 465     LYS B  1537                                                      
REMARK 465     MET B  1538                                                      
REMARK 465     GLU B  1539                                                      
REMARK 465     LEU B  1540                                                      
REMARK 465     GLN B  1541                                                      
REMARK 465     SER B  1542                                                      
REMARK 465     ALA B  1543                                                      
REMARK 465     LEU B  1544                                                      
REMARK 465     GLU B  1545                                                      
REMARK 465     GLU B  1546                                                      
REMARK 465     ALA B  1547                                                      
REMARK 465     GLU B  1548                                                      
REMARK 465     ALA B  1549                                                      
REMARK 465     SER B  1550                                                      
REMARK 465     LEU B  1551                                                      
REMARK 465     GLU B  1552                                                      
REMARK 465     HIS B  1553                                                      
REMARK 465     GLU B  1554                                                      
REMARK 465     GLU B  1555                                                      
REMARK 465     GLY B  1556                                                      
REMARK 465     LYS B  1557                                                      
REMARK 465     ILE B  1558                                                      
REMARK 465     LEU B  1559                                                      
REMARK 465     ARG B  1560                                                      
REMARK 465     ALA B  1561                                                      
REMARK 465     GLN B  1562                                                      
REMARK 465     LEU B  1563                                                      
REMARK 465     GLU B  1564                                                      
REMARK 465     PHE B  1565                                                      
REMARK 465     ASN B  1566                                                      
REMARK 465     GLN B  1567                                                      
REMARK 465     ILE B  1568                                                      
REMARK 465     LYS B  1569                                                      
REMARK 465     ALA B  1570                                                      
REMARK 465     GLU B  1571                                                      
REMARK 465     ILE B  1572                                                      
REMARK 465     GLU B  1573                                                      
REMARK 465     ARG B  1574                                                      
REMARK 465     LYS B  1575                                                      
REMARK 465     LEU B  1576                                                      
REMARK 465     ALA B  1577                                                      
REMARK 465     GLU B  1578                                                      
REMARK 465     LYS B  1579                                                      
REMARK 465     ASP B  1580                                                      
REMARK 465     GLU B  1581                                                      
REMARK 465     GLU B  1582                                                      
REMARK 465     MET B  1583                                                      
REMARK 465     GLU B  1584                                                      
REMARK 465     GLN B  1585                                                      
REMARK 465     ALA B  1586                                                      
REMARK 465     LYS B  1587                                                      
REMARK 465     ARG B  1588                                                      
REMARK 465     ASN B  1589                                                      
REMARK 465     HIS B  1590                                                      
REMARK 465     LEU B  1591                                                      
REMARK 465     ARG B  1592                                                      
REMARK 465     VAL B  1593                                                      
REMARK 465     VAL B  1594                                                      
REMARK 465     ASP B  1595                                                      
REMARK 465     SER B  1596                                                      
REMARK 465     LEU B  1597                                                      
REMARK 465     GLN B  1598                                                      
REMARK 465     THR B  1599                                                      
REMARK 465     SER B  1600                                                      
REMARK 465     LEU B  1601                                                      
REMARK 465     ASP B  1602                                                      
REMARK 465     ALA B  1603                                                      
REMARK 465     GLU B  1604                                                      
REMARK 465     THR B  1605                                                      
REMARK 465     ARG B  1606                                                      
REMARK 465     SER B  1607                                                      
REMARK 465     ARG B  1608                                                      
REMARK 465     ASN B  1609                                                      
REMARK 465     GLU B  1610                                                      
REMARK 465     ALA B  1611                                                      
REMARK 465     LEU B  1612                                                      
REMARK 465     ARG B  1613                                                      
REMARK 465     VAL B  1614                                                      
REMARK 465     LYS B  1615                                                      
REMARK 465     LYS B  1616                                                      
REMARK 465     LYS B  1617                                                      
REMARK 465     MET B  1618                                                      
REMARK 465     GLU B  1619                                                      
REMARK 465     GLY B  1620                                                      
REMARK 465     ASP B  1621                                                      
REMARK 465     LEU B  1622                                                      
REMARK 465     ASN B  1623                                                      
REMARK 465     GLU B  1624                                                      
REMARK 465     MET B  1625                                                      
REMARK 465     GLU B  1626                                                      
REMARK 465     ILE B  1627                                                      
REMARK 465     GLN B  1628                                                      
REMARK 465     LEU B  1629                                                      
REMARK 465     SER B  1630                                                      
REMARK 465     HIS B  1631                                                      
REMARK 465     ALA B  1632                                                      
REMARK 465     ASN B  1633                                                      
REMARK 465     ARG B  1634                                                      
REMARK 465     MET B  1635                                                      
REMARK 465     ALA B  1636                                                      
REMARK 465     ALA B  1637                                                      
REMARK 465     GLU B  1638                                                      
REMARK 465     ALA B  1639                                                      
REMARK 465     GLN B  1640                                                      
REMARK 465     LYS B  1641                                                      
REMARK 465     GLN B  1642                                                      
REMARK 465     VAL B  1643                                                      
REMARK 465     LYS B  1644                                                      
REMARK 465     SER B  1645                                                      
REMARK 465     LEU B  1646                                                      
REMARK 465     GLN B  1647                                                      
REMARK 465     SER B  1648                                                      
REMARK 465     LEU B  1649                                                      
REMARK 465     LEU B  1650                                                      
REMARK 465     LYS B  1651                                                      
REMARK 465     ASP B  1652                                                      
REMARK 465     THR B  1653                                                      
REMARK 465     GLN B  1654                                                      
REMARK 465     ILE B  1655                                                      
REMARK 465     GLN B  1656                                                      
REMARK 465     LEU B  1657                                                      
REMARK 465     ASP B  1658                                                      
REMARK 465     ASP B  1659                                                      
REMARK 465     ALA B  1660                                                      
REMARK 465     VAL B  1661                                                      
REMARK 465     ARG B  1662                                                      
REMARK 465     ALA B  1663                                                      
REMARK 465     ASN B  1664                                                      
REMARK 465     ASP B  1665                                                      
REMARK 465     ASP B  1666                                                      
REMARK 465     LEU B  1667                                                      
REMARK 465     LYS B  1668                                                      
REMARK 465     GLU B  1669                                                      
REMARK 465     ASN B  1670                                                      
REMARK 465     ILE B  1671                                                      
REMARK 465     ALA B  1672                                                      
REMARK 465     ILE B  1673                                                      
REMARK 465     VAL B  1674                                                      
REMARK 465     GLU B  1675                                                      
REMARK 465     ARG B  1676                                                      
REMARK 465     ARG B  1677                                                      
REMARK 465     ASN B  1678                                                      
REMARK 465     ASN B  1679                                                      
REMARK 465     LEU B  1680                                                      
REMARK 465     LEU B  1681                                                      
REMARK 465     GLN B  1682                                                      
REMARK 465     ALA B  1683                                                      
REMARK 465     GLU B  1684                                                      
REMARK 465     LEU B  1685                                                      
REMARK 465     GLU B  1686                                                      
REMARK 465     GLU B  1687                                                      
REMARK 465     LEU B  1688                                                      
REMARK 465     ARG B  1689                                                      
REMARK 465     ALA B  1690                                                      
REMARK 465     VAL B  1691                                                      
REMARK 465     VAL B  1692                                                      
REMARK 465     GLU B  1693                                                      
REMARK 465     GLN B  1694                                                      
REMARK 465     THR B  1695                                                      
REMARK 465     GLU B  1696                                                      
REMARK 465     ARG B  1697                                                      
REMARK 465     SER B  1698                                                      
REMARK 465     ARG B  1699                                                      
REMARK 465     LYS B  1700                                                      
REMARK 465     LEU B  1701                                                      
REMARK 465     ALA B  1702                                                      
REMARK 465     GLU B  1703                                                      
REMARK 465     GLN B  1704                                                      
REMARK 465     GLU B  1705                                                      
REMARK 465     LEU B  1706                                                      
REMARK 465     ILE B  1707                                                      
REMARK 465     GLU B  1708                                                      
REMARK 465     THR B  1709                                                      
REMARK 465     SER B  1710                                                      
REMARK 465     GLU B  1711                                                      
REMARK 465     ARG B  1712                                                      
REMARK 465     VAL B  1713                                                      
REMARK 465     GLN B  1714                                                      
REMARK 465     LEU B  1715                                                      
REMARK 465     LEU B  1716                                                      
REMARK 465     HIS B  1717                                                      
REMARK 465     SER B  1718                                                      
REMARK 465     GLN B  1719                                                      
REMARK 465     ASN B  1720                                                      
REMARK 465     THR B  1721                                                      
REMARK 465     SER B  1722                                                      
REMARK 465     LEU B  1723                                                      
REMARK 465     ILE B  1724                                                      
REMARK 465     ASN B  1725                                                      
REMARK 465     GLN B  1726                                                      
REMARK 465     LYS B  1727                                                      
REMARK 465     LYS B  1728                                                      
REMARK 465     LYS B  1729                                                      
REMARK 465     MET B  1730                                                      
REMARK 465     ASP B  1731                                                      
REMARK 465     ALA B  1732                                                      
REMARK 465     ASP B  1733                                                      
REMARK 465     LEU B  1734                                                      
REMARK 465     SER B  1735                                                      
REMARK 465     GLN B  1736                                                      
REMARK 465     LEU B  1737                                                      
REMARK 465     GLN B  1738                                                      
REMARK 465     THR B  1739                                                      
REMARK 465     GLU B  1740                                                      
REMARK 465     VAL B  1741                                                      
REMARK 465     GLU B  1742                                                      
REMARK 465     GLU B  1743                                                      
REMARK 465     ALA B  1744                                                      
REMARK 465     VAL B  1745                                                      
REMARK 465     GLN B  1746                                                      
REMARK 465     GLU B  1747                                                      
REMARK 465     CYS B  1748                                                      
REMARK 465     ARG B  1749                                                      
REMARK 465     ASN B  1750                                                      
REMARK 465     ALA B  1751                                                      
REMARK 465     GLU B  1752                                                      
REMARK 465     GLU B  1753                                                      
REMARK 465     LYS B  1754                                                      
REMARK 465     ALA B  1755                                                      
REMARK 465     LYS B  1756                                                      
REMARK 465     LYS B  1757                                                      
REMARK 465     ALA B  1758                                                      
REMARK 465     ILE B  1759                                                      
REMARK 465     THR B  1760                                                      
REMARK 465     ASP B  1761                                                      
REMARK 465     ALA B  1762                                                      
REMARK 465     ALA B  1763                                                      
REMARK 465     MET B  1764                                                      
REMARK 465     MET B  1765                                                      
REMARK 465     ALA B  1766                                                      
REMARK 465     GLU B  1767                                                      
REMARK 465     GLU B  1768                                                      
REMARK 465     LEU B  1769                                                      
REMARK 465     LYS B  1770                                                      
REMARK 465     LYS B  1771                                                      
REMARK 465     GLU B  1772                                                      
REMARK 465     GLN B  1773                                                      
REMARK 465     ASP B  1774                                                      
REMARK 465     THR B  1775                                                      
REMARK 465     SER B  1776                                                      
REMARK 465     ALA B  1777                                                      
REMARK 465     HIS B  1778                                                      
REMARK 465     LEU B  1779                                                      
REMARK 465     GLU B  1780                                                      
REMARK 465     ARG B  1781                                                      
REMARK 465     MET B  1782                                                      
REMARK 465     LYS B  1783                                                      
REMARK 465     LYS B  1784                                                      
REMARK 465     ASN B  1785                                                      
REMARK 465     MET B  1786                                                      
REMARK 465     GLU B  1787                                                      
REMARK 465     GLN B  1788                                                      
REMARK 465     THR B  1789                                                      
REMARK 465     ILE B  1790                                                      
REMARK 465     LYS B  1791                                                      
REMARK 465     ASP B  1792                                                      
REMARK 465     LEU B  1793                                                      
REMARK 465     GLN B  1794                                                      
REMARK 465     HIS B  1795                                                      
REMARK 465     ARG B  1796                                                      
REMARK 465     LEU B  1797                                                      
REMARK 465     ASP B  1798                                                      
REMARK 465     GLU B  1799                                                      
REMARK 465     ALA B  1800                                                      
REMARK 465     GLU B  1801                                                      
REMARK 465     GLN B  1802                                                      
REMARK 465     ILE B  1803                                                      
REMARK 465     ALA B  1804                                                      
REMARK 465     LEU B  1805                                                      
REMARK 465     LYS B  1806                                                      
REMARK 465     GLY B  1807                                                      
REMARK 465     GLY B  1808                                                      
REMARK 465     LYS B  1809                                                      
REMARK 465     LYS B  1810                                                      
REMARK 465     GLN B  1811                                                      
REMARK 465     LEU B  1812                                                      
REMARK 465     GLN B  1813                                                      
REMARK 465     LYS B  1814                                                      
REMARK 465     LEU B  1815                                                      
REMARK 465     GLU B  1816                                                      
REMARK 465     ALA B  1817                                                      
REMARK 465     ARG B  1818                                                      
REMARK 465     VAL B  1819                                                      
REMARK 465     ARG B  1820                                                      
REMARK 465     GLU B  1821                                                      
REMARK 465     LEU B  1822                                                      
REMARK 465     GLU B  1823                                                      
REMARK 465     ASN B  1824                                                      
REMARK 465     GLU B  1825                                                      
REMARK 465     LEU B  1826                                                      
REMARK 465     GLU B  1827                                                      
REMARK 465     ALA B  1828                                                      
REMARK 465     GLU B  1829                                                      
REMARK 465     GLN B  1830                                                      
REMARK 465     LYS B  1831                                                      
REMARK 465     ARG B  1832                                                      
REMARK 465     ASN B  1833                                                      
REMARK 465     ALA B  1834                                                      
REMARK 465     GLU B  1835                                                      
REMARK 465     SER B  1836                                                      
REMARK 465     VAL B  1837                                                      
REMARK 465     LYS B  1838                                                      
REMARK 465     GLY B  1839                                                      
REMARK 465     MET B  1840                                                      
REMARK 465     ARG B  1841                                                      
REMARK 465     LYS B  1842                                                      
REMARK 465     SER B  1843                                                      
REMARK 465     GLU B  1844                                                      
REMARK 465     ARG B  1845                                                      
REMARK 465     ARG B  1846                                                      
REMARK 465     ILE B  1847                                                      
REMARK 465     LYS B  1848                                                      
REMARK 465     GLU B  1849                                                      
REMARK 465     LEU B  1850                                                      
REMARK 465     THR B  1851                                                      
REMARK 465     TYR B  1852                                                      
REMARK 465     GLN B  1853                                                      
REMARK 465     THR B  1854                                                      
REMARK 465     GLU B  1855                                                      
REMARK 465     GLU B  1856                                                      
REMARK 465     ASP B  1857                                                      
REMARK 465     ARG B  1858                                                      
REMARK 465     LYS B  1859                                                      
REMARK 465     ASN B  1860                                                      
REMARK 465     LEU B  1861                                                      
REMARK 465     LEU B  1862                                                      
REMARK 465     ARG B  1863                                                      
REMARK 465     LEU B  1864                                                      
REMARK 465     GLN B  1865                                                      
REMARK 465     ASP B  1866                                                      
REMARK 465     LEU B  1867                                                      
REMARK 465     VAL B  1868                                                      
REMARK 465     ASP B  1869                                                      
REMARK 465     LYS B  1870                                                      
REMARK 465     LEU B  1871                                                      
REMARK 465     GLN B  1872                                                      
REMARK 465     LEU B  1873                                                      
REMARK 465     LYS B  1874                                                      
REMARK 465     VAL B  1875                                                      
REMARK 465     LYS B  1876                                                      
REMARK 465     ALA B  1877                                                      
REMARK 465     TYR B  1878                                                      
REMARK 465     LYS B  1879                                                      
REMARK 465     ARG B  1880                                                      
REMARK 465     GLN B  1881                                                      
REMARK 465     ALA B  1882                                                      
REMARK 465     GLU B  1883                                                      
REMARK 465     GLU B  1884                                                      
REMARK 465     ALA B  1885                                                      
REMARK 465     GLU B  1886                                                      
REMARK 465     GLU B  1887                                                      
REMARK 465     GLN B  1888                                                      
REMARK 465     ALA B  1889                                                      
REMARK 465     ASN B  1890                                                      
REMARK 465     THR B  1891                                                      
REMARK 465     ASN B  1892                                                      
REMARK 465     LEU B  1893                                                      
REMARK 465     SER B  1894                                                      
REMARK 465     LYS B  1895                                                      
REMARK 465     PHE B  1896                                                      
REMARK 465     ARG B  1897                                                      
REMARK 465     LYS B  1898                                                      
REMARK 465     VAL B  1899                                                      
REMARK 465     GLN B  1900                                                      
REMARK 465     HIS B  1901                                                      
REMARK 465     GLU B  1902                                                      
REMARK 465     LEU B  1903                                                      
REMARK 465     ASP B  1904                                                      
REMARK 465     GLU B  1905                                                      
REMARK 465     ALA B  1906                                                      
REMARK 465     GLU B  1907                                                      
REMARK 465     GLU B  1908                                                      
REMARK 465     ARG B  1909                                                      
REMARK 465     ALA B  1910                                                      
REMARK 465     ASP B  1911                                                      
REMARK 465     ILE B  1912                                                      
REMARK 465     ALA B  1913                                                      
REMARK 465     GLU B  1914                                                      
REMARK 465     SER B  1915                                                      
REMARK 465     GLN B  1916                                                      
REMARK 465     VAL B  1917                                                      
REMARK 465     ASN B  1918                                                      
REMARK 465     LYS B  1919                                                      
REMARK 465     LEU B  1920                                                      
REMARK 465     ARG B  1921                                                      
REMARK 465     ALA B  1922                                                      
REMARK 465     LYS B  1923                                                      
REMARK 465     SER B  1924                                                      
REMARK 465     ARG B  1925                                                      
REMARK 465     ASP B  1926                                                      
REMARK 465     ILE B  1927                                                      
REMARK 465     GLY B  1928                                                      
REMARK 465     THR B  1929                                                      
REMARK 465     LYS B  1930                                                      
REMARK 465     GLY B  1931                                                      
REMARK 465     LEU B  1932                                                      
REMARK 465     ASN B  1933                                                      
REMARK 465     GLU B  1934                                                      
REMARK 465     GLU B  1935                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     PRO C     3                                                      
REMARK 465     LYS C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     PRO C     6                                                      
REMARK 465     GLU C     7                                                      
REMARK 465     PRO C     8                                                      
REMARK 465     LYS C     9                                                      
REMARK 465     LYS C    10                                                      
REMARK 465     ASP C    11                                                      
REMARK 465     ASP C    12                                                      
REMARK 465     ALA C    13                                                      
REMARK 465     LYS C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     ALA C    16                                                      
REMARK 465     PRO C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     ALA C    19                                                      
REMARK 465     ALA C    20                                                      
REMARK 465     PRO C    21                                                      
REMARK 465     ALA C    22                                                      
REMARK 465     PRO C    23                                                      
REMARK 465     ALA C    24                                                      
REMARK 465     PRO C    25                                                      
REMARK 465     PRO C    26                                                      
REMARK 465     PRO C    27                                                      
REMARK 465     GLU C    28                                                      
REMARK 465     PRO C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     ARG C    31                                                      
REMARK 465     PRO C    32                                                      
REMARK 465     LYS C    33                                                      
REMARK 465     GLU C    34                                                      
REMARK 465     VAL C    35                                                      
REMARK 465     GLU C    36                                                      
REMARK 465     PHE C    37                                                      
REMARK 465     ASP C    38                                                      
REMARK 465     ALA C    39                                                      
REMARK 465     SER C    40                                                      
REMARK 465     LYS C    41                                                      
REMARK 465     ILE C    42                                                      
REMARK 465     LYS C    43                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     PRO D     3                                                      
REMARK 465     LYS D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     PRO D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     PRO D     8                                                      
REMARK 465     LYS D     9                                                      
REMARK 465     LYS D    10                                                      
REMARK 465     ASP D    11                                                      
REMARK 465     ASP D    12                                                      
REMARK 465     ALA D    13                                                      
REMARK 465     LYS D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     PRO D    17                                                      
REMARK 465     LYS D    18                                                      
REMARK 465     ALA D    19                                                      
REMARK 465     ALA D    20                                                      
REMARK 465     PRO D    21                                                      
REMARK 465     ALA D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     ALA D    24                                                      
REMARK 465     PRO D    25                                                      
REMARK 465     PRO D    26                                                      
REMARK 465     PRO D    27                                                      
REMARK 465     GLU D    28                                                      
REMARK 465     PRO D    29                                                      
REMARK 465     GLU D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     PRO D    32                                                      
REMARK 465     LYS D    33                                                      
REMARK 465     GLU D    34                                                      
REMARK 465     VAL D    35                                                      
REMARK 465     GLU D    36                                                      
REMARK 465     PHE D    37                                                      
REMARK 465     ASP D    38                                                      
REMARK 465     ALA D    39                                                      
REMARK 465     SER D    40                                                      
REMARK 465     LYS D    41                                                      
REMARK 465     ILE D    42                                                      
REMARK 465     LYS D    43                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     PRO E     3                                                      
REMARK 465     LYS E     4                                                      
REMARK 465     LYS E     5                                                      
REMARK 465     ALA E     6                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     PRO F     3                                                      
REMARK 465     LYS F     4                                                      
REMARK 465     LYS F     5                                                      
REMARK 465     ALA F     6                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH2  ARG B   787     O    THR D   127              0.45            
REMARK 500   C    GLU B   732     CG   GLU D   135              0.60            
REMARK 500   O    GLU B   732     CD   GLU D   135              0.70            
REMARK 500   NH2  ARG A   787     N    GLY C   128              0.72            
REMARK 500   CE1  PHE B   834     CB   GLU F   164              0.72            
REMARK 500   CG   LEU A   908     CD2  LEU B   908              0.80            
REMARK 500   NH1  ARG A   845     CD   GLN F    23              0.82            
REMARK 500   NE   ARG A   845     NE   ARG B   845              0.82            
REMARK 500   CD1  LEU A   908     CD2  LEU B   908              0.88            
REMARK 500   NE2  HIS A   760     OD2  ASP B   376              0.89            
REMARK 500   CD2  LEU A   859     CG   LEU B   859              0.90            
REMARK 500   CE   LYS A   803     CA   PRO E   108              0.90            
REMARK 500   CD2  LEU A   859     CD2  LEU B   859              0.91            
REMARK 500   CG   LEU A   859     CD2  LEU B   859              0.95            
REMARK 500   CD2  LEU B   811     C    THR D    64              0.99            
REMARK 500   O    GLU B   732     CG   GLU D   135              1.00            
REMARK 500   CD1  LEU A   714     CB   LEU B   396              1.00            
REMARK 500   CD2  LEU A   908     CG   LEU B   908              1.01            
REMARK 500   CZ   ARG B   787     O    THR D   127              1.03            
REMARK 500   CD   LYS A   803     N    PRO E   108              1.04            
REMARK 500   CD2  LEU B   811     N    PRO D    65              1.09            
REMARK 500   NH1  ARG A   845     CG   GLN F    23              1.09            
REMARK 500   NE   ARG A   845     CZ   ARG B   845              1.11            
REMARK 500   NH2  ARG A   787     C    THR C   127              1.12            
REMARK 500   C    LYS B   825     NE   ARG F    58              1.13            
REMARK 500   O    GLU B   732     OE2  GLU D   135              1.53            
REMARK 500   CD   ARG A   845     OE1  GLN F    23              1.62            
REMARK 500   NE   ARG A   787     C    THR C   127              1.62            
REMARK 500   CD2  HIS A   760     OD2  ASP B   376              1.63            
REMARK 500   CZ   ARG A   845     OE1  GLN F    23              1.66            
REMARK 500   CD2  LEU A   908     CD2  LEU B   908              1.66            
REMARK 500   CG   GLN A   454     CD2  TYR B   410              1.67            
REMARK 500   NE   ARG A   845     OE1  GLN F    23              1.68            
REMARK 500   NH1  ARG B   719     O    VAL D   139              1.70            
REMARK 500   CB   LEU A   859     CD2  LEU B   859              1.71            
REMARK 500   N    GLY B   733     CB   GLU D   135              1.72            
REMARK 500   CD2  LEU A   859     CB   LEU B   859              1.72            
REMARK 500   OE1  GLN A   791     CZ   PHE C   133              1.73            
REMARK 500   CE1  TYR A   455     NH1  ARG B   403              1.73            
REMARK 500   CD   ARG A   845     CZ   ARG B   845              1.73            
REMARK 500   CG   PRO D    65     OE1  GLN F   126              1.73            
REMARK 500   CD   LYS A   803     CG   PRO E   108              1.76            
REMARK 500   CD1  ILE A   788     CG   PHE C   133              1.76            
REMARK 500   CE1  PHE B   834     CG   GLU F   164              1.76            
REMARK 500   O    GLU B   732     OE1  GLU D   135              1.77            
REMARK 500   NH2  ARG A   787     CA   THR C   127              1.78            
REMARK 500   NE   ARG A   845     CD   ARG B   845              1.79            
REMARK 500   N    GLY B   733     NH2  ARG D   138              1.79            
REMARK 500   NE2  HIS A   760     CG   ASP B   376              1.79            
REMARK 500   CE1  PHE B   834     CA   GLU F   164              1.80            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     133 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TRP A 112   CG    TRP A 112   CD1    -0.123                       
REMARK 500    TRP A 112   CE2   TRP A 112   CD2    -0.102                       
REMARK 500    HIS B 666   NE2   HIS B 666   CD2    -0.130                       
REMARK 500    GLN D 101   C     GLN D 101   O      -0.208                       
REMARK 500    ARG E 129   NE    ARG E 129   CZ      0.122                       
REMARK 500    ARG E 129   CZ    ARG E 129   NH1    -0.255                       
REMARK 500    ARG E 129   CZ    ARG E 129   NH2     0.120                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A  14   C   -  N   -  CA  ANGL. DEV. =  10.0 DEGREES          
REMARK 500    ARG A  29   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    ARG A  29   NE  -  CZ  -  NH2 ANGL. DEV. =   3.0 DEGREES          
REMARK 500    LYS A  34   CA  -  CB  -  CG  ANGL. DEV. =  14.9 DEGREES          
REMARK 500    GLU A  45   OE1 -  CD  -  OE2 ANGL. DEV. =  14.2 DEGREES          
REMARK 500    PHE A  46   CG  -  CD1 -  CE1 ANGL. DEV. =   9.2 DEGREES          
REMARK 500    PHE A  46   CZ  -  CE2 -  CD2 ANGL. DEV. =   7.5 DEGREES          
REMARK 500    TYR A  65   CB  -  CG  -  CD2 ANGL. DEV. =  -3.7 DEGREES          
REMARK 500    TRP A 112   CB  -  CG  -  CD1 ANGL. DEV. =  -8.0 DEGREES          
REMARK 500    TRP A 112   CD2 -  CE2 -  CZ2 ANGL. DEV. =   7.4 DEGREES          
REMARK 500    SER A 210   N   -  CA  -  CB  ANGL. DEV. =   9.3 DEGREES          
REMARK 500    ASP A 282   CB  -  CG  -  OD1 ANGL. DEV. =  -6.6 DEGREES          
REMARK 500    VAL A 320   CG1 -  CB  -  CG2 ANGL. DEV. = -15.4 DEGREES          
REMARK 500    LEU A 366   N   -  CA  -  CB  ANGL. DEV. = -14.6 DEGREES          
REMARK 500    LYS A 367   C   -  N   -  CA  ANGL. DEV. =  21.6 DEGREES          
REMARK 500    VAL A 404   CG1 -  CB  -  CG2 ANGL. DEV. = -11.3 DEGREES          
REMARK 500    PRO A 452   CA  -  N   -  CD  ANGL. DEV. = -10.2 DEGREES          
REMARK 500    ALA A 575   N   -  CA  -  CB  ANGL. DEV. =  -9.4 DEGREES          
REMARK 500    MET A 684   CG  -  SD  -  CE  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    ILE A 736   CG1 -  CB  -  CG2 ANGL. DEV. = -14.9 DEGREES          
REMARK 500    TYR A 756   CB  -  CG  -  CD2 ANGL. DEV. =  -6.7 DEGREES          
REMARK 500    TYR A 756   CB  -  CG  -  CD1 ANGL. DEV. =   6.5 DEGREES          
REMARK 500    TYR A 756   CG  -  CD2 -  CE2 ANGL. DEV. =  -7.9 DEGREES          
REMARK 500    TYR A 756   CZ  -  CE2 -  CD2 ANGL. DEV. =  14.2 DEGREES          
REMARK 500    ASP B  36   N   -  CA  -  CB  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    PHE B  38   CG  -  CD2 -  CE2 ANGL. DEV. =   8.5 DEGREES          
REMARK 500    TYR B  65   CG  -  CD1 -  CE1 ANGL. DEV. =  -5.5 DEGREES          
REMARK 500    TYR B  65   CD1 -  CE1 -  CZ  ANGL. DEV. =   7.7 DEGREES          
REMARK 500    LEU B 102   CB  -  CG  -  CD2 ANGL. DEV. = -21.4 DEGREES          
REMARK 500    TYR B 109   CB  -  CG  -  CD2 ANGL. DEV. =  -6.2 DEGREES          
REMARK 500    TYR B 109   CB  -  CG  -  CD1 ANGL. DEV. =   5.6 DEGREES          
REMARK 500    VAL B 139   CA  -  CB  -  CG1 ANGL. DEV. = -10.7 DEGREES          
REMARK 500    ALA B 199   N   -  CA  -  CB  ANGL. DEV. = -15.1 DEGREES          
REMARK 500    ASP B 282   CB  -  CG  -  OD1 ANGL. DEV. =  -5.6 DEGREES          
REMARK 500    MET B 349   CG  -  SD  -  CE  ANGL. DEV. = -12.2 DEGREES          
REMARK 500    LEU B 352   CB  -  CG  -  CD1 ANGL. DEV. = -10.9 DEGREES          
REMARK 500    LEU B 390   CB  -  CG  -  CD1 ANGL. DEV. = -11.3 DEGREES          
REMARK 500    CYS B 538   CA  -  CB  -  SG  ANGL. DEV. = -11.0 DEGREES          
REMARK 500    LYS B 549   CD  -  CE  -  NZ  ANGL. DEV. =  15.0 DEGREES          
REMARK 500    ASP B 599   CB  -  CG  -  OD2 ANGL. DEV. =  -5.5 DEGREES          
REMARK 500    LEU B 617   CB  -  CG  -  CD2 ANGL. DEV. = -10.8 DEGREES          
REMARK 500    LEU B 620   CD1 -  CG  -  CD2 ANGL. DEV. = -21.1 DEGREES          
REMARK 500    LYS B 635   CA  -  C   -  N   ANGL. DEV. =  13.0 DEGREES          
REMARK 500    GLY B 636   C   -  N   -  CA  ANGL. DEV. =  16.9 DEGREES          
REMARK 500    GLY B 641   CA  -  C   -  O   ANGL. DEV. = -24.3 DEGREES          
REMARK 500    GLY B 641   CA  -  C   -  N   ANGL. DEV. =  25.2 DEGREES          
REMARK 500    HIS B 666   CB  -  CG  -  CD2 ANGL. DEV. = -11.9 DEGREES          
REMARK 500    HIS B 666   ND1 -  CE1 -  NE2 ANGL. DEV. =  -8.3 DEGREES          
REMARK 500    HIS B 666   CE1 -  NE2 -  CD2 ANGL. DEV. =  13.7 DEGREES          
REMARK 500    HIS B 666   CG  -  CD2 -  NE2 ANGL. DEV. = -11.1 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      69 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  11      -55.24      1.08                                   
REMARK 500    TYR A  15       24.47    -75.16                                   
REMARK 500    LEU A  16      -49.74   -166.47                                   
REMARK 500    ARG A  17     -159.06    -98.44                                   
REMARK 500    SER A  19       86.35    -69.46                                   
REMARK 500    GLU A  22     -175.29    176.63                                   
REMARK 500    LEU A  24       84.22    -66.80                                   
REMARK 500    GLN A  27      -64.83      9.09                                   
REMARK 500    PRO A  30      102.59    -57.26                                   
REMARK 500    LYS A  43      -58.17   -126.56                                   
REMARK 500    GLU A  45      -97.46     62.93                                   
REMARK 500    GLU A  64       90.10    -56.96                                   
REMARK 500    TYR A  65       33.74     81.78                                   
REMARK 500    LYS A  67     -163.17   -120.22                                   
REMARK 500    VAL A  71     -146.29   -113.79                                   
REMARK 500    VAL A  76      108.74    -56.33                                   
REMARK 500    LEU A  96       64.21   -113.25                                   
REMARK 500    TRP A 112      -25.42     71.74                                   
REMARK 500    MET A 113       95.61    -62.59                                   
REMARK 500    SER A 118       55.55   -142.22                                   
REMARK 500    PRO A 132       26.67    -74.50                                   
REMARK 500    ARG A 143       91.84    -49.36                                   
REMARK 500    SER A 148       38.78    -85.63                                   
REMARK 500    PRO A 152      107.37    -54.65                                   
REMARK 500    ARG A 169       -9.45     76.27                                   
REMARK 500    GLU A 179     -159.86    -70.19                                   
REMARK 500    ALA A 182     -150.52    -73.35                                   
REMARK 500    LYS A 184      -78.28    -95.41                                   
REMARK 500    ASP A 208       41.20    -20.73                                   
REMARK 500    GLN A 209      -60.18   -121.71                                   
REMARK 500    SER A 210       95.07     81.47                                   
REMARK 500    PHE A 230       40.87    -87.97                                   
REMARK 500    ASN A 240       66.72   -112.78                                   
REMARK 500    LEU A 267      138.29    -30.88                                   
REMARK 500    LYS A 270       35.76    -96.69                                   
REMARK 500    SER A 271      -72.30    -51.65                                   
REMARK 500    ARG A 272      -39.48    170.05                                   
REMARK 500    VAL A 273       28.15    -78.42                                   
REMARK 500    ILE A 274     -129.35   -146.35                                   
REMARK 500    LEU A 277     -152.29   -105.46                                   
REMARK 500    ARG A 281     -145.84   -115.01                                   
REMARK 500    ASP A 282     -100.24   -115.25                                   
REMARK 500    ILE A 285       33.68    -85.82                                   
REMARK 500    LEU A 302       93.45     41.39                                   
REMARK 500    THR A 304     -157.87    -73.06                                   
REMARK 500    ASN A 305       86.25   -165.46                                   
REMARK 500    PRO A 307      -79.61    -70.24                                   
REMARK 500    ASP A 309      155.03     79.81                                   
REMARK 500    TYR A 310     -148.18     50.77                                   
REMARK 500    ILE A 313      -82.34    137.49                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     305 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TYR A  308     ASP A  309                  149.85                    
REMARK 500 TYR A  310     ALA A  311                 -138.51                    
REMARK 500 ILE A  313     SER A  314                 -127.63                    
REMARK 500 ARG A  369     GLU A  370                  141.85                    
REMARK 500 LYS A  413     GLY A  414                  143.67                    
REMARK 500 GLY A  634     LYS A  635                 -122.49                    
REMARK 500 GLN B  209     SER B  210                  -94.10                    
REMARK 500 LYS B  572     PRO B  573                 -139.56                    
REMARK 500 ASN B  623     TYR B  624                 -130.69                    
REMARK 500 LYS B  633     GLY B  634                 -145.47                    
REMARK 500 GLN B  734     PHE B  735                  140.32                    
REMARK 500 SER B  866     GLU B  867                  148.05                    
REMARK 500 GLN C  101     GLU C  102                  118.54                    
REMARK 500 VAL E   59     ASN E   60                   48.37                    
REMARK 500 VAL F   59     ASN F   60                 -145.46                    
REMARK 500 THR F   84     MET F   85                  147.31                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR A  15         0.06    SIDE CHAIN                              
REMARK 500    TYR A 115         0.09    SIDE CHAIN                              
REMARK 500    TYR A 162         0.09    SIDE CHAIN                              
REMARK 500    TYR A 310         0.10    SIDE CHAIN                              
REMARK 500    ARG A 369         0.10    SIDE CHAIN                              
REMARK 500    TYR A 588         0.14    SIDE CHAIN                              
REMARK 500    TYR A 722         0.15    SIDE CHAIN                              
REMARK 500    TYR A 756         0.08    SIDE CHAIN                              
REMARK 500    PHE A 821         0.07    SIDE CHAIN                              
REMARK 500    ARG A 870         0.12    SIDE CHAIN                              
REMARK 500    ARG B 108         0.12    SIDE CHAIN                              
REMARK 500    TYR B 164         0.14    SIDE CHAIN                              
REMARK 500    PHE B 465         0.08    SIDE CHAIN                              
REMARK 500    TYR B 501         0.07    SIDE CHAIN                              
REMARK 500    PHE B 644         0.08    SIDE CHAIN                              
REMARK 500    ARG B 671         0.13    SIDE CHAIN                              
REMARK 500    TYR B 715         0.10    SIDE CHAIN                              
REMARK 500    TYR C 185         0.06    SIDE CHAIN                              
REMARK 500    ARG E 129         0.07    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    GLU A  25        -11.03                                           
REMARK 500    GLU A  45         14.53                                           
REMARK 500    ILE A 274         10.32                                           
REMARK 500    LYS A 635         10.56                                           
REMARK 500    GLU B  45         10.52                                           
REMARK 500    ALA B 141        -10.31                                           
REMARK 500    VAL B 197        -18.90                                           
REMARK 500    LYS B 633        -17.21                                           
REMARK 500    GLY B 636         16.46                                           
REMARK 500    GLN B 734         13.84                                           
REMARK 500    THR E 125         20.51                                           
REMARK 500    LYS F  91         13.18                                           
REMARK 500    PRO F  95         12.99                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-1950   RELATED DB: EMDB                              
REMARK 900 3D-STRUCTURE OF TARANTULA MYOSIN FILAMENT OBTAINED BY CRYO-ELECTRON  
REMARK 900 MICROSCOPY                                                           
REMARK 900 RELATED ID: 3JBH   RELATED DB: PDB                                   
REMARK 900 TWO INTERACTING-HEADS MOTIFS FLEXIBLE DOCKED INTO TARANTULA THICK    
REMARK 900 FILAMENT 3D-MAP ALLOWS IN DEPTH STUDY OF INTRA- E INTERMOLECULAR     
REMARK 900 INTERACTIONS                                                         
REMARK 900 RELATED ID: EMD-2240   RELATED DB: EMDB                              
REMARK 900 3D STRUCTURE OF MYOSIN FILAMENTS ISOLATED FROM HUMAN HEART MUSCLES   
REMARK 900 BY NEGATIVE STAIN ELECTRON MICROSCOPY AND SINGLE PARTICLE IMAGE      
REMARK 900 ANALYSIS                                                             
DBREF  5TBY A    1  1935  UNP    P12883   MYH7_HUMAN       1   1935             
DBREF  5TBY B    1  1935  UNP    P12883   MYH7_HUMAN       1   1935             
DBREF  5TBY C    1   195  UNP    P08590   MYL3_HUMAN       1    195             
DBREF  5TBY D    1   195  UNP    P08590   MYL3_HUMAN       1    195             
DBREF  5TBY E    1   166  UNP    P10916   MLRV_HUMAN       1    166             
DBREF  5TBY F    1   166  UNP    P10916   MLRV_HUMAN       1    166             
SEQRES   1 A 1935  MET GLY ASP SER GLU MET ALA VAL PHE GLY ALA ALA ALA          
SEQRES   2 A 1935  PRO TYR LEU ARG LYS SER GLU LYS GLU ARG LEU GLU ALA          
SEQRES   3 A 1935  GLN THR ARG PRO PHE ASP LEU LYS LYS ASP VAL PHE VAL          
SEQRES   4 A 1935  PRO ASP ASP LYS GLN GLU PHE VAL LYS ALA LYS ILE VAL          
SEQRES   5 A 1935  SER ARG GLU GLY GLY LYS VAL THR ALA GLU THR GLU TYR          
SEQRES   6 A 1935  GLY LYS THR VAL THR VAL LYS GLU ASP GLN VAL MET GLN          
SEQRES   7 A 1935  GLN ASN PRO PRO LYS PHE ASP LYS ILE GLU ASP MET ALA          
SEQRES   8 A 1935  MET LEU THR PHE LEU HIS GLU PRO ALA VAL LEU TYR ASN          
SEQRES   9 A 1935  LEU LYS ASP ARG TYR GLY SER TRP MET ILE TYR THR TYR          
SEQRES  10 A 1935  SER GLY LEU PHE CYS VAL THR VAL ASN PRO TYR LYS TRP          
SEQRES  11 A 1935  LEU PRO VAL TYR THR PRO GLU VAL VAL ALA ALA TYR ARG          
SEQRES  12 A 1935  GLY LYS LYS ARG SER GLU ALA PRO PRO HIS ILE PHE SER          
SEQRES  13 A 1935  ILE SER ASP ASN ALA TYR GLN TYR MET LEU THR ASP ARG          
SEQRES  14 A 1935  GLU ASN GLN SER ILE LEU ILE THR GLY GLU SER GLY ALA          
SEQRES  15 A 1935  GLY LYS THR VAL ASN THR LYS ARG VAL ILE GLN TYR PHE          
SEQRES  16 A 1935  ALA VAL ILE ALA ALA ILE GLY ASP ARG SER LYS LYS ASP          
SEQRES  17 A 1935  GLN SER PRO GLY LYS GLY THR LEU GLU ASP GLN ILE ILE          
SEQRES  18 A 1935  GLN ALA ASN PRO ALA LEU GLU ALA PHE GLY ASN ALA LYS          
SEQRES  19 A 1935  THR VAL ARG ASN ASP ASN SER SER ARG PHE GLY LYS PHE          
SEQRES  20 A 1935  ILE ARG ILE HIS PHE GLY ALA THR GLY LYS LEU ALA SER          
SEQRES  21 A 1935  ALA ASP ILE GLU THR TYR LEU LEU GLU LYS SER ARG VAL          
SEQRES  22 A 1935  ILE PHE GLN LEU LYS ALA GLU ARG ASP TYR HIS ILE PHE          
SEQRES  23 A 1935  TYR GLN ILE LEU SER ASN LYS LYS PRO GLU LEU LEU ASP          
SEQRES  24 A 1935  MET LEU LEU ILE THR ASN ASN PRO TYR ASP TYR ALA PHE          
SEQRES  25 A 1935  ILE SER GLN GLY GLU THR THR VAL ALA SER ILE ASP ASP          
SEQRES  26 A 1935  ALA GLU GLU LEU MET ALA THR ASP ASN ALA PHE ASP VAL          
SEQRES  27 A 1935  LEU GLY PHE THR SER GLU GLU LYS ASN SER MET TYR LYS          
SEQRES  28 A 1935  LEU THR GLY ALA ILE MET HIS PHE GLY ASN MET LYS PHE          
SEQRES  29 A 1935  LYS LEU LYS GLN ARG GLU GLU GLN ALA GLU PRO ASP GLY          
SEQRES  30 A 1935  THR GLU GLU ALA ASP LYS SER ALA TYR LEU MET GLY LEU          
SEQRES  31 A 1935  ASN SER ALA ASP LEU LEU LYS GLY LEU CYS HIS PRO ARG          
SEQRES  32 A 1935  VAL LYS VAL GLY ASN GLU TYR VAL THR LYS GLY GLN ASN          
SEQRES  33 A 1935  VAL GLN GLN VAL ILE TYR ALA THR GLY ALA LEU ALA LYS          
SEQRES  34 A 1935  ALA VAL TYR GLU ARG MET PHE ASN TRP MET VAL THR ARG          
SEQRES  35 A 1935  ILE ASN ALA THR LEU GLU THR LYS GLN PRO ARG GLN TYR          
SEQRES  36 A 1935  PHE ILE GLY VAL LEU ASP ILE ALA GLY PHE GLU ILE PHE          
SEQRES  37 A 1935  ASP PHE ASN SER PHE GLU GLN LEU CYS ILE ASN PHE THR          
SEQRES  38 A 1935  ASN GLU LYS LEU GLN GLN PHE PHE ASN HIS HIS MET PHE          
SEQRES  39 A 1935  VAL LEU GLU GLN GLU GLU TYR LYS LYS GLU GLY ILE GLU          
SEQRES  40 A 1935  TRP THR PHE ILE ASP PHE GLY MET ASP LEU GLN ALA CYS          
SEQRES  41 A 1935  ILE ASP LEU ILE GLU LYS PRO MET GLY ILE MET SER ILE          
SEQRES  42 A 1935  LEU GLU GLU GLU CYS MET PHE PRO LYS ALA THR ASP MET          
SEQRES  43 A 1935  THR PHE LYS ALA LYS LEU PHE ASP ASN HIS LEU GLY LYS          
SEQRES  44 A 1935  SER ALA ASN PHE GLN LYS PRO ARG ASN ILE LYS GLY LYS          
SEQRES  45 A 1935  PRO GLU ALA HIS PHE SER LEU ILE HIS TYR ALA GLY ILE          
SEQRES  46 A 1935  VAL ASP TYR ASN ILE ILE GLY TRP LEU GLN LYS ASN LYS          
SEQRES  47 A 1935  ASP PRO LEU ASN GLU THR VAL VAL GLY LEU TYR GLN LYS          
SEQRES  48 A 1935  SER SER LEU LYS LEU LEU SER THR LEU PHE ALA ASN TYR          
SEQRES  49 A 1935  ALA GLY ALA ASP ALA PRO ILE GLU LYS GLY LYS GLY LYS          
SEQRES  50 A 1935  ALA LYS LYS GLY SER SER PHE GLN THR VAL SER ALA LEU          
SEQRES  51 A 1935  HIS ARG GLU ASN LEU ASN LYS LEU MET THR ASN LEU ARG          
SEQRES  52 A 1935  SER THR HIS PRO HIS PHE VAL ARG CYS ILE ILE PRO ASN          
SEQRES  53 A 1935  GLU THR LYS SER PRO GLY VAL MET ASP ASN PRO LEU VAL          
SEQRES  54 A 1935  MET HIS GLN LEU ARG CYS ASN GLY VAL LEU GLU GLY ILE          
SEQRES  55 A 1935  ARG ILE CYS ARG LYS GLY PHE PRO ASN ARG ILE LEU TYR          
SEQRES  56 A 1935  GLY ASP PHE ARG GLN ARG TYR ARG ILE LEU ASN PRO ALA          
SEQRES  57 A 1935  ALA ILE PRO GLU GLY GLN PHE ILE ASP SER ARG LYS GLY          
SEQRES  58 A 1935  ALA GLU LYS LEU LEU SER SER LEU ASP ILE ASP HIS ASN          
SEQRES  59 A 1935  GLN TYR LYS PHE GLY HIS THR LYS VAL PHE PHE LYS ALA          
SEQRES  60 A 1935  GLY LEU LEU GLY LEU LEU GLU GLU MET ARG ASP GLU ARG          
SEQRES  61 A 1935  LEU SER ARG ILE ILE THR ARG ILE GLN ALA GLN SER ARG          
SEQRES  62 A 1935  GLY VAL LEU ALA ARG MET GLU TYR LYS LYS LEU LEU GLU          
SEQRES  63 A 1935  ARG ARG ASP SER LEU LEU VAL ILE GLN TRP ASN ILE ARG          
SEQRES  64 A 1935  ALA PHE MET GLY VAL LYS ASN TRP PRO TRP MET LYS LEU          
SEQRES  65 A 1935  TYR PHE LYS ILE LYS PRO LEU LEU LYS SER ALA GLU ARG          
SEQRES  66 A 1935  GLU LYS GLU MET ALA SER MET LYS GLU GLU PHE THR ARG          
SEQRES  67 A 1935  LEU LYS GLU ALA LEU GLU LYS SER GLU ALA ARG ARG LYS          
SEQRES  68 A 1935  GLU LEU GLU GLU LYS MET VAL SER LEU LEU GLN GLU LYS          
SEQRES  69 A 1935  ASN ASP LEU GLN LEU GLN VAL GLN ALA GLU GLN ASP ASN          
SEQRES  70 A 1935  LEU ALA ASP ALA GLU GLU ARG CYS ASP GLN LEU ILE LYS          
SEQRES  71 A 1935  ASN LYS ILE GLN LEU GLU ALA LYS VAL LYS GLU MET ASN          
SEQRES  72 A 1935  GLU ARG LEU GLU ASP GLU GLU GLU MET ASN ALA GLU LEU          
SEQRES  73 A 1935  THR ALA LYS LYS ARG LYS LEU GLU ASP GLU CYS SER GLU          
SEQRES  74 A 1935  LEU LYS ARG ASP ILE ASP ASP LEU GLU LEU THR LEU ALA          
SEQRES  75 A 1935  LYS VAL GLU LYS GLU LYS HIS ALA THR GLU ASN LYS VAL          
SEQRES  76 A 1935  LYS ASN LEU THR GLU GLU MET ALA GLY LEU ASP GLU ILE          
SEQRES  77 A 1935  ILE ALA LYS LEU THR LYS GLU LYS LYS ALA LEU GLN GLU          
SEQRES  78 A 1935  ALA HIS GLN GLN ALA LEU ASP ASP LEU GLN ALA GLU GLU          
SEQRES  79 A 1935  ASP LYS VAL ASN THR LEU THR LYS ALA LYS VAL LYS LEU          
SEQRES  80 A 1935  GLU GLN GLN VAL ASP ASP LEU GLU GLY SER LEU GLU GLN          
SEQRES  81 A 1935  GLU LYS LYS VAL ARG MET ASP LEU GLU ARG ALA LYS ARG          
SEQRES  82 A 1935  LYS LEU GLU GLY ASP LEU LYS LEU THR GLN GLU SER ILE          
SEQRES  83 A 1935  MET ASP LEU GLU ASN ASP LYS GLN GLN LEU ASP GLU ARG          
SEQRES  84 A 1935  LEU LYS LYS LYS ASP PHE GLU LEU ASN ALA LEU ASN ALA          
SEQRES  85 A 1935  ARG ILE GLU ASP GLU GLN ALA LEU GLY SER GLN LEU GLN          
SEQRES  86 A 1935  LYS LYS LEU LYS GLU LEU GLN ALA ARG ILE GLU GLU LEU          
SEQRES  87 A 1935  GLU GLU GLU LEU GLU ALA GLU ARG THR ALA ARG ALA LYS          
SEQRES  88 A 1935  VAL GLU LYS LEU ARG SER ASP LEU SER ARG GLU LEU GLU          
SEQRES  89 A 1935  GLU ILE SER GLU ARG LEU GLU GLU ALA GLY GLY ALA THR          
SEQRES  90 A 1935  SER VAL GLN ILE GLU MET ASN LYS LYS ARG GLU ALA GLU          
SEQRES  91 A 1935  PHE GLN LYS MET ARG ARG ASP LEU GLU GLU ALA THR LEU          
SEQRES  92 A 1935  GLN HIS GLU ALA THR ALA ALA ALA LEU ARG LYS LYS HIS          
SEQRES  93 A 1935  ALA ASP SER VAL ALA GLU LEU GLY GLU GLN ILE ASP ASN          
SEQRES  94 A 1935  LEU GLN ARG VAL LYS GLN LYS LEU GLU LYS GLU LYS SER          
SEQRES  95 A 1935  GLU PHE LYS LEU GLU LEU ASP ASP VAL THR SER ASN MET          
SEQRES  96 A 1935  GLU GLN ILE ILE LYS ALA LYS ALA ASN LEU GLU LYS MET          
SEQRES  97 A 1935  CYS ARG THR LEU GLU ASP GLN MET ASN GLU HIS ARG SER          
SEQRES  98 A 1935  LYS ALA GLU GLU THR GLN ARG SER VAL ASN ASP LEU THR          
SEQRES  99 A 1935  SER GLN ARG ALA LYS LEU GLN THR GLU ASN GLY GLU LEU          
SEQRES 100 A 1935  SER ARG GLN LEU ASP GLU LYS GLU ALA LEU ILE SER GLN          
SEQRES 101 A 1935  LEU THR ARG GLY LYS LEU THR TYR THR GLN GLN LEU GLU          
SEQRES 102 A 1935  ASP LEU LYS ARG GLN LEU GLU GLU GLU VAL LYS ALA LYS          
SEQRES 103 A 1935  ASN ALA LEU ALA HIS ALA LEU GLN SER ALA ARG HIS ASP          
SEQRES 104 A 1935  CYS ASP LEU LEU ARG GLU GLN TYR GLU GLU GLU THR GLU          
SEQRES 105 A 1935  ALA LYS ALA GLU LEU GLN ARG VAL LEU SER LYS ALA ASN          
SEQRES 106 A 1935  SER GLU VAL ALA GLN TRP ARG THR LYS TYR GLU THR ASP          
SEQRES 107 A 1935  ALA ILE GLN ARG THR GLU GLU LEU GLU GLU ALA LYS LYS          
SEQRES 108 A 1935  LYS LEU ALA GLN ARG LEU GLN GLU ALA GLU GLU ALA VAL          
SEQRES 109 A 1935  GLU ALA VAL ASN ALA LYS CYS SER SER LEU GLU LYS THR          
SEQRES 110 A 1935  LYS HIS ARG LEU GLN ASN GLU ILE GLU ASP LEU MET VAL          
SEQRES 111 A 1935  ASP VAL GLU ARG SER ASN ALA ALA ALA ALA ALA LEU ASP          
SEQRES 112 A 1935  LYS LYS GLN ARG ASN PHE ASP LYS ILE LEU ALA GLU TRP          
SEQRES 113 A 1935  LYS GLN LYS TYR GLU GLU SER GLN SER GLU LEU GLU SER          
SEQRES 114 A 1935  SER GLN LYS GLU ALA ARG SER LEU SER THR GLU LEU PHE          
SEQRES 115 A 1935  LYS LEU LYS ASN ALA TYR GLU GLU SER LEU GLU HIS LEU          
SEQRES 116 A 1935  GLU THR PHE LYS ARG GLU ASN LYS ASN LEU GLN GLU GLU          
SEQRES 117 A 1935  ILE SER ASP LEU THR GLU GLN LEU GLY SER SER GLY LYS          
SEQRES 118 A 1935  THR ILE HIS GLU LEU GLU LYS VAL ARG LYS GLN LEU GLU          
SEQRES 119 A 1935  ALA GLU LYS MET GLU LEU GLN SER ALA LEU GLU GLU ALA          
SEQRES 120 A 1935  GLU ALA SER LEU GLU HIS GLU GLU GLY LYS ILE LEU ARG          
SEQRES 121 A 1935  ALA GLN LEU GLU PHE ASN GLN ILE LYS ALA GLU ILE GLU          
SEQRES 122 A 1935  ARG LYS LEU ALA GLU LYS ASP GLU GLU MET GLU GLN ALA          
SEQRES 123 A 1935  LYS ARG ASN HIS LEU ARG VAL VAL ASP SER LEU GLN THR          
SEQRES 124 A 1935  SER LEU ASP ALA GLU THR ARG SER ARG ASN GLU ALA LEU          
SEQRES 125 A 1935  ARG VAL LYS LYS LYS MET GLU GLY ASP LEU ASN GLU MET          
SEQRES 126 A 1935  GLU ILE GLN LEU SER HIS ALA ASN ARG MET ALA ALA GLU          
SEQRES 127 A 1935  ALA GLN LYS GLN VAL LYS SER LEU GLN SER LEU LEU LYS          
SEQRES 128 A 1935  ASP THR GLN ILE GLN LEU ASP ASP ALA VAL ARG ALA ASN          
SEQRES 129 A 1935  ASP ASP LEU LYS GLU ASN ILE ALA ILE VAL GLU ARG ARG          
SEQRES 130 A 1935  ASN ASN LEU LEU GLN ALA GLU LEU GLU GLU LEU ARG ALA          
SEQRES 131 A 1935  VAL VAL GLU GLN THR GLU ARG SER ARG LYS LEU ALA GLU          
SEQRES 132 A 1935  GLN GLU LEU ILE GLU THR SER GLU ARG VAL GLN LEU LEU          
SEQRES 133 A 1935  HIS SER GLN ASN THR SER LEU ILE ASN GLN LYS LYS LYS          
SEQRES 134 A 1935  MET ASP ALA ASP LEU SER GLN LEU GLN THR GLU VAL GLU          
SEQRES 135 A 1935  GLU ALA VAL GLN GLU CYS ARG ASN ALA GLU GLU LYS ALA          
SEQRES 136 A 1935  LYS LYS ALA ILE THR ASP ALA ALA MET MET ALA GLU GLU          
SEQRES 137 A 1935  LEU LYS LYS GLU GLN ASP THR SER ALA HIS LEU GLU ARG          
SEQRES 138 A 1935  MET LYS LYS ASN MET GLU GLN THR ILE LYS ASP LEU GLN          
SEQRES 139 A 1935  HIS ARG LEU ASP GLU ALA GLU GLN ILE ALA LEU LYS GLY          
SEQRES 140 A 1935  GLY LYS LYS GLN LEU GLN LYS LEU GLU ALA ARG VAL ARG          
SEQRES 141 A 1935  GLU LEU GLU ASN GLU LEU GLU ALA GLU GLN LYS ARG ASN          
SEQRES 142 A 1935  ALA GLU SER VAL LYS GLY MET ARG LYS SER GLU ARG ARG          
SEQRES 143 A 1935  ILE LYS GLU LEU THR TYR GLN THR GLU GLU ASP ARG LYS          
SEQRES 144 A 1935  ASN LEU LEU ARG LEU GLN ASP LEU VAL ASP LYS LEU GLN          
SEQRES 145 A 1935  LEU LYS VAL LYS ALA TYR LYS ARG GLN ALA GLU GLU ALA          
SEQRES 146 A 1935  GLU GLU GLN ALA ASN THR ASN LEU SER LYS PHE ARG LYS          
SEQRES 147 A 1935  VAL GLN HIS GLU LEU ASP GLU ALA GLU GLU ARG ALA ASP          
SEQRES 148 A 1935  ILE ALA GLU SER GLN VAL ASN LYS LEU ARG ALA LYS SER          
SEQRES 149 A 1935  ARG ASP ILE GLY THR LYS GLY LEU ASN GLU GLU                  
SEQRES   1 B 1935  MET GLY ASP SER GLU MET ALA VAL PHE GLY ALA ALA ALA          
SEQRES   2 B 1935  PRO TYR LEU ARG LYS SER GLU LYS GLU ARG LEU GLU ALA          
SEQRES   3 B 1935  GLN THR ARG PRO PHE ASP LEU LYS LYS ASP VAL PHE VAL          
SEQRES   4 B 1935  PRO ASP ASP LYS GLN GLU PHE VAL LYS ALA LYS ILE VAL          
SEQRES   5 B 1935  SER ARG GLU GLY GLY LYS VAL THR ALA GLU THR GLU TYR          
SEQRES   6 B 1935  GLY LYS THR VAL THR VAL LYS GLU ASP GLN VAL MET GLN          
SEQRES   7 B 1935  GLN ASN PRO PRO LYS PHE ASP LYS ILE GLU ASP MET ALA          
SEQRES   8 B 1935  MET LEU THR PHE LEU HIS GLU PRO ALA VAL LEU TYR ASN          
SEQRES   9 B 1935  LEU LYS ASP ARG TYR GLY SER TRP MET ILE TYR THR TYR          
SEQRES  10 B 1935  SER GLY LEU PHE CYS VAL THR VAL ASN PRO TYR LYS TRP          
SEQRES  11 B 1935  LEU PRO VAL TYR THR PRO GLU VAL VAL ALA ALA TYR ARG          
SEQRES  12 B 1935  GLY LYS LYS ARG SER GLU ALA PRO PRO HIS ILE PHE SER          
SEQRES  13 B 1935  ILE SER ASP ASN ALA TYR GLN TYR MET LEU THR ASP ARG          
SEQRES  14 B 1935  GLU ASN GLN SER ILE LEU ILE THR GLY GLU SER GLY ALA          
SEQRES  15 B 1935  GLY LYS THR VAL ASN THR LYS ARG VAL ILE GLN TYR PHE          
SEQRES  16 B 1935  ALA VAL ILE ALA ALA ILE GLY ASP ARG SER LYS LYS ASP          
SEQRES  17 B 1935  GLN SER PRO GLY LYS GLY THR LEU GLU ASP GLN ILE ILE          
SEQRES  18 B 1935  GLN ALA ASN PRO ALA LEU GLU ALA PHE GLY ASN ALA LYS          
SEQRES  19 B 1935  THR VAL ARG ASN ASP ASN SER SER ARG PHE GLY LYS PHE          
SEQRES  20 B 1935  ILE ARG ILE HIS PHE GLY ALA THR GLY LYS LEU ALA SER          
SEQRES  21 B 1935  ALA ASP ILE GLU THR TYR LEU LEU GLU LYS SER ARG VAL          
SEQRES  22 B 1935  ILE PHE GLN LEU LYS ALA GLU ARG ASP TYR HIS ILE PHE          
SEQRES  23 B 1935  TYR GLN ILE LEU SER ASN LYS LYS PRO GLU LEU LEU ASP          
SEQRES  24 B 1935  MET LEU LEU ILE THR ASN ASN PRO TYR ASP TYR ALA PHE          
SEQRES  25 B 1935  ILE SER GLN GLY GLU THR THR VAL ALA SER ILE ASP ASP          
SEQRES  26 B 1935  ALA GLU GLU LEU MET ALA THR ASP ASN ALA PHE ASP VAL          
SEQRES  27 B 1935  LEU GLY PHE THR SER GLU GLU LYS ASN SER MET TYR LYS          
SEQRES  28 B 1935  LEU THR GLY ALA ILE MET HIS PHE GLY ASN MET LYS PHE          
SEQRES  29 B 1935  LYS LEU LYS GLN ARG GLU GLU GLN ALA GLU PRO ASP GLY          
SEQRES  30 B 1935  THR GLU GLU ALA ASP LYS SER ALA TYR LEU MET GLY LEU          
SEQRES  31 B 1935  ASN SER ALA ASP LEU LEU LYS GLY LEU CYS HIS PRO ARG          
SEQRES  32 B 1935  VAL LYS VAL GLY ASN GLU TYR VAL THR LYS GLY GLN ASN          
SEQRES  33 B 1935  VAL GLN GLN VAL ILE TYR ALA THR GLY ALA LEU ALA LYS          
SEQRES  34 B 1935  ALA VAL TYR GLU ARG MET PHE ASN TRP MET VAL THR ARG          
SEQRES  35 B 1935  ILE ASN ALA THR LEU GLU THR LYS GLN PRO ARG GLN TYR          
SEQRES  36 B 1935  PHE ILE GLY VAL LEU ASP ILE ALA GLY PHE GLU ILE PHE          
SEQRES  37 B 1935  ASP PHE ASN SER PHE GLU GLN LEU CYS ILE ASN PHE THR          
SEQRES  38 B 1935  ASN GLU LYS LEU GLN GLN PHE PHE ASN HIS HIS MET PHE          
SEQRES  39 B 1935  VAL LEU GLU GLN GLU GLU TYR LYS LYS GLU GLY ILE GLU          
SEQRES  40 B 1935  TRP THR PHE ILE ASP PHE GLY MET ASP LEU GLN ALA CYS          
SEQRES  41 B 1935  ILE ASP LEU ILE GLU LYS PRO MET GLY ILE MET SER ILE          
SEQRES  42 B 1935  LEU GLU GLU GLU CYS MET PHE PRO LYS ALA THR ASP MET          
SEQRES  43 B 1935  THR PHE LYS ALA LYS LEU PHE ASP ASN HIS LEU GLY LYS          
SEQRES  44 B 1935  SER ALA ASN PHE GLN LYS PRO ARG ASN ILE LYS GLY LYS          
SEQRES  45 B 1935  PRO GLU ALA HIS PHE SER LEU ILE HIS TYR ALA GLY ILE          
SEQRES  46 B 1935  VAL ASP TYR ASN ILE ILE GLY TRP LEU GLN LYS ASN LYS          
SEQRES  47 B 1935  ASP PRO LEU ASN GLU THR VAL VAL GLY LEU TYR GLN LYS          
SEQRES  48 B 1935  SER SER LEU LYS LEU LEU SER THR LEU PHE ALA ASN TYR          
SEQRES  49 B 1935  ALA GLY ALA ASP ALA PRO ILE GLU LYS GLY LYS GLY LYS          
SEQRES  50 B 1935  ALA LYS LYS GLY SER SER PHE GLN THR VAL SER ALA LEU          
SEQRES  51 B 1935  HIS ARG GLU ASN LEU ASN LYS LEU MET THR ASN LEU ARG          
SEQRES  52 B 1935  SER THR HIS PRO HIS PHE VAL ARG CYS ILE ILE PRO ASN          
SEQRES  53 B 1935  GLU THR LYS SER PRO GLY VAL MET ASP ASN PRO LEU VAL          
SEQRES  54 B 1935  MET HIS GLN LEU ARG CYS ASN GLY VAL LEU GLU GLY ILE          
SEQRES  55 B 1935  ARG ILE CYS ARG LYS GLY PHE PRO ASN ARG ILE LEU TYR          
SEQRES  56 B 1935  GLY ASP PHE ARG GLN ARG TYR ARG ILE LEU ASN PRO ALA          
SEQRES  57 B 1935  ALA ILE PRO GLU GLY GLN PHE ILE ASP SER ARG LYS GLY          
SEQRES  58 B 1935  ALA GLU LYS LEU LEU SER SER LEU ASP ILE ASP HIS ASN          
SEQRES  59 B 1935  GLN TYR LYS PHE GLY HIS THR LYS VAL PHE PHE LYS ALA          
SEQRES  60 B 1935  GLY LEU LEU GLY LEU LEU GLU GLU MET ARG ASP GLU ARG          
SEQRES  61 B 1935  LEU SER ARG ILE ILE THR ARG ILE GLN ALA GLN SER ARG          
SEQRES  62 B 1935  GLY VAL LEU ALA ARG MET GLU TYR LYS LYS LEU LEU GLU          
SEQRES  63 B 1935  ARG ARG ASP SER LEU LEU VAL ILE GLN TRP ASN ILE ARG          
SEQRES  64 B 1935  ALA PHE MET GLY VAL LYS ASN TRP PRO TRP MET LYS LEU          
SEQRES  65 B 1935  TYR PHE LYS ILE LYS PRO LEU LEU LYS SER ALA GLU ARG          
SEQRES  66 B 1935  GLU LYS GLU MET ALA SER MET LYS GLU GLU PHE THR ARG          
SEQRES  67 B 1935  LEU LYS GLU ALA LEU GLU LYS SER GLU ALA ARG ARG LYS          
SEQRES  68 B 1935  GLU LEU GLU GLU LYS MET VAL SER LEU LEU GLN GLU LYS          
SEQRES  69 B 1935  ASN ASP LEU GLN LEU GLN VAL GLN ALA GLU GLN ASP ASN          
SEQRES  70 B 1935  LEU ALA ASP ALA GLU GLU ARG CYS ASP GLN LEU ILE LYS          
SEQRES  71 B 1935  ASN LYS ILE GLN LEU GLU ALA LYS VAL LYS GLU MET ASN          
SEQRES  72 B 1935  GLU ARG LEU GLU ASP GLU GLU GLU MET ASN ALA GLU LEU          
SEQRES  73 B 1935  THR ALA LYS LYS ARG LYS LEU GLU ASP GLU CYS SER GLU          
SEQRES  74 B 1935  LEU LYS ARG ASP ILE ASP ASP LEU GLU LEU THR LEU ALA          
SEQRES  75 B 1935  LYS VAL GLU LYS GLU LYS HIS ALA THR GLU ASN LYS VAL          
SEQRES  76 B 1935  LYS ASN LEU THR GLU GLU MET ALA GLY LEU ASP GLU ILE          
SEQRES  77 B 1935  ILE ALA LYS LEU THR LYS GLU LYS LYS ALA LEU GLN GLU          
SEQRES  78 B 1935  ALA HIS GLN GLN ALA LEU ASP ASP LEU GLN ALA GLU GLU          
SEQRES  79 B 1935  ASP LYS VAL ASN THR LEU THR LYS ALA LYS VAL LYS LEU          
SEQRES  80 B 1935  GLU GLN GLN VAL ASP ASP LEU GLU GLY SER LEU GLU GLN          
SEQRES  81 B 1935  GLU LYS LYS VAL ARG MET ASP LEU GLU ARG ALA LYS ARG          
SEQRES  82 B 1935  LYS LEU GLU GLY ASP LEU LYS LEU THR GLN GLU SER ILE          
SEQRES  83 B 1935  MET ASP LEU GLU ASN ASP LYS GLN GLN LEU ASP GLU ARG          
SEQRES  84 B 1935  LEU LYS LYS LYS ASP PHE GLU LEU ASN ALA LEU ASN ALA          
SEQRES  85 B 1935  ARG ILE GLU ASP GLU GLN ALA LEU GLY SER GLN LEU GLN          
SEQRES  86 B 1935  LYS LYS LEU LYS GLU LEU GLN ALA ARG ILE GLU GLU LEU          
SEQRES  87 B 1935  GLU GLU GLU LEU GLU ALA GLU ARG THR ALA ARG ALA LYS          
SEQRES  88 B 1935  VAL GLU LYS LEU ARG SER ASP LEU SER ARG GLU LEU GLU          
SEQRES  89 B 1935  GLU ILE SER GLU ARG LEU GLU GLU ALA GLY GLY ALA THR          
SEQRES  90 B 1935  SER VAL GLN ILE GLU MET ASN LYS LYS ARG GLU ALA GLU          
SEQRES  91 B 1935  PHE GLN LYS MET ARG ARG ASP LEU GLU GLU ALA THR LEU          
SEQRES  92 B 1935  GLN HIS GLU ALA THR ALA ALA ALA LEU ARG LYS LYS HIS          
SEQRES  93 B 1935  ALA ASP SER VAL ALA GLU LEU GLY GLU GLN ILE ASP ASN          
SEQRES  94 B 1935  LEU GLN ARG VAL LYS GLN LYS LEU GLU LYS GLU LYS SER          
SEQRES  95 B 1935  GLU PHE LYS LEU GLU LEU ASP ASP VAL THR SER ASN MET          
SEQRES  96 B 1935  GLU GLN ILE ILE LYS ALA LYS ALA ASN LEU GLU LYS MET          
SEQRES  97 B 1935  CYS ARG THR LEU GLU ASP GLN MET ASN GLU HIS ARG SER          
SEQRES  98 B 1935  LYS ALA GLU GLU THR GLN ARG SER VAL ASN ASP LEU THR          
SEQRES  99 B 1935  SER GLN ARG ALA LYS LEU GLN THR GLU ASN GLY GLU LEU          
SEQRES 100 B 1935  SER ARG GLN LEU ASP GLU LYS GLU ALA LEU ILE SER GLN          
SEQRES 101 B 1935  LEU THR ARG GLY LYS LEU THR TYR THR GLN GLN LEU GLU          
SEQRES 102 B 1935  ASP LEU LYS ARG GLN LEU GLU GLU GLU VAL LYS ALA LYS          
SEQRES 103 B 1935  ASN ALA LEU ALA HIS ALA LEU GLN SER ALA ARG HIS ASP          
SEQRES 104 B 1935  CYS ASP LEU LEU ARG GLU GLN TYR GLU GLU GLU THR GLU          
SEQRES 105 B 1935  ALA LYS ALA GLU LEU GLN ARG VAL LEU SER LYS ALA ASN          
SEQRES 106 B 1935  SER GLU VAL ALA GLN TRP ARG THR LYS TYR GLU THR ASP          
SEQRES 107 B 1935  ALA ILE GLN ARG THR GLU GLU LEU GLU GLU ALA LYS LYS          
SEQRES 108 B 1935  LYS LEU ALA GLN ARG LEU GLN GLU ALA GLU GLU ALA VAL          
SEQRES 109 B 1935  GLU ALA VAL ASN ALA LYS CYS SER SER LEU GLU LYS THR          
SEQRES 110 B 1935  LYS HIS ARG LEU GLN ASN GLU ILE GLU ASP LEU MET VAL          
SEQRES 111 B 1935  ASP VAL GLU ARG SER ASN ALA ALA ALA ALA ALA LEU ASP          
SEQRES 112 B 1935  LYS LYS GLN ARG ASN PHE ASP LYS ILE LEU ALA GLU TRP          
SEQRES 113 B 1935  LYS GLN LYS TYR GLU GLU SER GLN SER GLU LEU GLU SER          
SEQRES 114 B 1935  SER GLN LYS GLU ALA ARG SER LEU SER THR GLU LEU PHE          
SEQRES 115 B 1935  LYS LEU LYS ASN ALA TYR GLU GLU SER LEU GLU HIS LEU          
SEQRES 116 B 1935  GLU THR PHE LYS ARG GLU ASN LYS ASN LEU GLN GLU GLU          
SEQRES 117 B 1935  ILE SER ASP LEU THR GLU GLN LEU GLY SER SER GLY LYS          
SEQRES 118 B 1935  THR ILE HIS GLU LEU GLU LYS VAL ARG LYS GLN LEU GLU          
SEQRES 119 B 1935  ALA GLU LYS MET GLU LEU GLN SER ALA LEU GLU GLU ALA          
SEQRES 120 B 1935  GLU ALA SER LEU GLU HIS GLU GLU GLY LYS ILE LEU ARG          
SEQRES 121 B 1935  ALA GLN LEU GLU PHE ASN GLN ILE LYS ALA GLU ILE GLU          
SEQRES 122 B 1935  ARG LYS LEU ALA GLU LYS ASP GLU GLU MET GLU GLN ALA          
SEQRES 123 B 1935  LYS ARG ASN HIS LEU ARG VAL VAL ASP SER LEU GLN THR          
SEQRES 124 B 1935  SER LEU ASP ALA GLU THR ARG SER ARG ASN GLU ALA LEU          
SEQRES 125 B 1935  ARG VAL LYS LYS LYS MET GLU GLY ASP LEU ASN GLU MET          
SEQRES 126 B 1935  GLU ILE GLN LEU SER HIS ALA ASN ARG MET ALA ALA GLU          
SEQRES 127 B 1935  ALA GLN LYS GLN VAL LYS SER LEU GLN SER LEU LEU LYS          
SEQRES 128 B 1935  ASP THR GLN ILE GLN LEU ASP ASP ALA VAL ARG ALA ASN          
SEQRES 129 B 1935  ASP ASP LEU LYS GLU ASN ILE ALA ILE VAL GLU ARG ARG          
SEQRES 130 B 1935  ASN ASN LEU LEU GLN ALA GLU LEU GLU GLU LEU ARG ALA          
SEQRES 131 B 1935  VAL VAL GLU GLN THR GLU ARG SER ARG LYS LEU ALA GLU          
SEQRES 132 B 1935  GLN GLU LEU ILE GLU THR SER GLU ARG VAL GLN LEU LEU          
SEQRES 133 B 1935  HIS SER GLN ASN THR SER LEU ILE ASN GLN LYS LYS LYS          
SEQRES 134 B 1935  MET ASP ALA ASP LEU SER GLN LEU GLN THR GLU VAL GLU          
SEQRES 135 B 1935  GLU ALA VAL GLN GLU CYS ARG ASN ALA GLU GLU LYS ALA          
SEQRES 136 B 1935  LYS LYS ALA ILE THR ASP ALA ALA MET MET ALA GLU GLU          
SEQRES 137 B 1935  LEU LYS LYS GLU GLN ASP THR SER ALA HIS LEU GLU ARG          
SEQRES 138 B 1935  MET LYS LYS ASN MET GLU GLN THR ILE LYS ASP LEU GLN          
SEQRES 139 B 1935  HIS ARG LEU ASP GLU ALA GLU GLN ILE ALA LEU LYS GLY          
SEQRES 140 B 1935  GLY LYS LYS GLN LEU GLN LYS LEU GLU ALA ARG VAL ARG          
SEQRES 141 B 1935  GLU LEU GLU ASN GLU LEU GLU ALA GLU GLN LYS ARG ASN          
SEQRES 142 B 1935  ALA GLU SER VAL LYS GLY MET ARG LYS SER GLU ARG ARG          
SEQRES 143 B 1935  ILE LYS GLU LEU THR TYR GLN THR GLU GLU ASP ARG LYS          
SEQRES 144 B 1935  ASN LEU LEU ARG LEU GLN ASP LEU VAL ASP LYS LEU GLN          
SEQRES 145 B 1935  LEU LYS VAL LYS ALA TYR LYS ARG GLN ALA GLU GLU ALA          
SEQRES 146 B 1935  GLU GLU GLN ALA ASN THR ASN LEU SER LYS PHE ARG LYS          
SEQRES 147 B 1935  VAL GLN HIS GLU LEU ASP GLU ALA GLU GLU ARG ALA ASP          
SEQRES 148 B 1935  ILE ALA GLU SER GLN VAL ASN LYS LEU ARG ALA LYS SER          
SEQRES 149 B 1935  ARG ASP ILE GLY THR LYS GLY LEU ASN GLU GLU                  
SEQRES   1 C  195  MET ALA PRO LYS LYS PRO GLU PRO LYS LYS ASP ASP ALA          
SEQRES   2 C  195  LYS ALA ALA PRO LYS ALA ALA PRO ALA PRO ALA PRO PRO          
SEQRES   3 C  195  PRO GLU PRO GLU ARG PRO LYS GLU VAL GLU PHE ASP ALA          
SEQRES   4 C  195  SER LYS ILE LYS ILE GLU PHE THR PRO GLU GLN ILE GLU          
SEQRES   5 C  195  GLU PHE LYS GLU ALA PHE MET LEU PHE ASP ARG THR PRO          
SEQRES   6 C  195  LYS CYS GLU MET LYS ILE THR TYR GLY GLN CYS GLY ASP          
SEQRES   7 C  195  VAL LEU ARG ALA LEU GLY GLN ASN PRO THR GLN ALA GLU          
SEQRES   8 C  195  VAL LEU ARG VAL LEU GLY LYS PRO ARG GLN GLU GLU LEU          
SEQRES   9 C  195  ASN THR LYS MET MET ASP PHE GLU THR PHE LEU PRO MET          
SEQRES  10 C  195  LEU GLN HIS ILE SER LYS ASN LYS ASP THR GLY THR TYR          
SEQRES  11 C  195  GLU ASP PHE VAL GLU GLY LEU ARG VAL PHE ASP LYS GLU          
SEQRES  12 C  195  GLY ASN GLY THR VAL MET GLY ALA GLU LEU ARG HIS VAL          
SEQRES  13 C  195  LEU ALA THR LEU GLY GLU ARG LEU THR GLU ASP GLU VAL          
SEQRES  14 C  195  GLU LYS LEU MET ALA GLY GLN GLU ASP SER ASN GLY CYS          
SEQRES  15 C  195  ILE ASN TYR GLU ALA PHE VAL LYS HIS ILE MET SER SER          
SEQRES   1 D  195  MET ALA PRO LYS LYS PRO GLU PRO LYS LYS ASP ASP ALA          
SEQRES   2 D  195  LYS ALA ALA PRO LYS ALA ALA PRO ALA PRO ALA PRO PRO          
SEQRES   3 D  195  PRO GLU PRO GLU ARG PRO LYS GLU VAL GLU PHE ASP ALA          
SEQRES   4 D  195  SER LYS ILE LYS ILE GLU PHE THR PRO GLU GLN ILE GLU          
SEQRES   5 D  195  GLU PHE LYS GLU ALA PHE MET LEU PHE ASP ARG THR PRO          
SEQRES   6 D  195  LYS CYS GLU MET LYS ILE THR TYR GLY GLN CYS GLY ASP          
SEQRES   7 D  195  VAL LEU ARG ALA LEU GLY GLN ASN PRO THR GLN ALA GLU          
SEQRES   8 D  195  VAL LEU ARG VAL LEU GLY LYS PRO ARG GLN GLU GLU LEU          
SEQRES   9 D  195  ASN THR LYS MET MET ASP PHE GLU THR PHE LEU PRO MET          
SEQRES  10 D  195  LEU GLN HIS ILE SER LYS ASN LYS ASP THR GLY THR TYR          
SEQRES  11 D  195  GLU ASP PHE VAL GLU GLY LEU ARG VAL PHE ASP LYS GLU          
SEQRES  12 D  195  GLY ASN GLY THR VAL MET GLY ALA GLU LEU ARG HIS VAL          
SEQRES  13 D  195  LEU ALA THR LEU GLY GLU ARG LEU THR GLU ASP GLU VAL          
SEQRES  14 D  195  GLU LYS LEU MET ALA GLY GLN GLU ASP SER ASN GLY CYS          
SEQRES  15 D  195  ILE ASN TYR GLU ALA PHE VAL LYS HIS ILE MET SER SER          
SEQRES   1 E  166  MET ALA PRO LYS LYS ALA LYS LYS ARG ALA GLY GLY ALA          
SEQRES   2 E  166  ASN SER ASN VAL PHE SER MET PHE GLU GLN THR GLN ILE          
SEQRES   3 E  166  GLN GLU PHE LYS GLU ALA PHE THR ILE MET ASP GLN ASN          
SEQRES   4 E  166  ARG ASP GLY PHE ILE ASP LYS ASN ASP LEU ARG ASP THR          
SEQRES   5 E  166  PHE ALA ALA LEU GLY ARG VAL ASN VAL LYS ASN GLU GLU          
SEQRES   6 E  166  ILE ASP GLU MET ILE LYS GLU ALA PRO GLY PRO ILE ASN          
SEQRES   7 E  166  PHE THR VAL PHE LEU THR MET PHE GLY GLU LYS LEU LYS          
SEQRES   8 E  166  GLY ALA ASP PRO GLU GLU THR ILE LEU ASN ALA PHE LYS          
SEQRES   9 E  166  VAL PHE ASP PRO GLU GLY LYS GLY VAL LEU LYS ALA ASP          
SEQRES  10 E  166  TYR VAL ARG GLU MET LEU THR THR GLN ALA GLU ARG PHE          
SEQRES  11 E  166  SER LYS GLU GLU VAL ASP GLN MET PHE ALA ALA PHE PRO          
SEQRES  12 E  166  PRO ASP VAL THR GLY ASN LEU ASP TYR LYS ASN LEU VAL          
SEQRES  13 E  166  HIS ILE ILE THR HIS GLY GLU GLU LYS ASP                      
SEQRES   1 F  166  MET ALA PRO LYS LYS ALA LYS LYS ARG ALA GLY GLY ALA          
SEQRES   2 F  166  ASN SER ASN VAL PHE SER MET PHE GLU GLN THR GLN ILE          
SEQRES   3 F  166  GLN GLU PHE LYS GLU ALA PHE THR ILE MET ASP GLN ASN          
SEQRES   4 F  166  ARG ASP GLY PHE ILE ASP LYS ASN ASP LEU ARG ASP THR          
SEQRES   5 F  166  PHE ALA ALA LEU GLY ARG VAL ASN VAL LYS ASN GLU GLU          
SEQRES   6 F  166  ILE ASP GLU MET ILE LYS GLU ALA PRO GLY PRO ILE ASN          
SEQRES   7 F  166  PHE THR VAL PHE LEU THR MET PHE GLY GLU LYS LEU LYS          
SEQRES   8 F  166  GLY ALA ASP PRO GLU GLU THR ILE LEU ASN ALA PHE LYS          
SEQRES   9 F  166  VAL PHE ASP PRO GLU GLY LYS GLY VAL LEU LYS ALA ASP          
SEQRES  10 F  166  TYR VAL ARG GLU MET LEU THR THR GLN ALA GLU ARG PHE          
SEQRES  11 F  166  SER LYS GLU GLU VAL ASP GLN MET PHE ALA ALA PHE PRO          
SEQRES  12 F  166  PRO ASP VAL THR GLY ASN LEU ASP TYR LYS ASN LEU VAL          
SEQRES  13 F  166  HIS ILE ILE THR HIS GLY GLU GLU LYS ASP                      
HELIX    1 AA1 ALA A   12  LEU A   16  5                                   5    
HELIX    2 AA2 GLU A   25  ARG A   29  5                                   5    
HELIX    3 AA3 ASP A   89  LEU A   93  5                                   5    
HELIX    4 AA4 HIS A   97  SER A  111  1                                  15    
HELIX    5 AA5 THR A  135  ARG A  143  1                                   9    
HELIX    6 AA6 LYS A  146  ALA A  150  5                                   5    
HELIX    7 AA7 HIS A  153  ARG A  169  1                                  17    
HELIX    8 AA8 LYS A  184  ALA A  199  1                                  16    
HELIX    9 AA9 GLY A  214  PHE A  230  1                                  17    
HELIX   10 AB1 TYR A  283  ASN A  292  1                                  10    
HELIX   11 AB2 LYS A  294  LEU A  301  1                                   8    
HELIX   12 AB3 GLU A  327  GLY A  340  1                                  14    
HELIX   13 AB4 THR A  342  PHE A  359  1                                  18    
HELIX   14 AB5 ALA A  381  GLY A  389  1                                   9    
HELIX   15 AB6 LEU A  395  CYS A  400  5                                   6    
HELIX   16 AB7 ASN A  416  THR A  424  1                                   9    
HELIX   17 AB8 ALA A  426  GLU A  448  1                                  23    
HELIX   18 AB9 GLN A  475  VAL A  495  1                                  21    
HELIX   19 AC1 VAL A  495  GLY A  505  1                                  11    
HELIX   20 AC2 GLY A  529  CYS A  538  1                                  10    
HELIX   21 AC3 THR A  544  ASN A  555  1                                  12    
HELIX   22 AC4 GLY A  592  ASN A  597  1                                   6    
HELIX   23 AC5 VAL A  606  LYS A  611  1                                   6    
HELIX   24 AC6 LEU A  614  PHE A  621  1                                   8    
HELIX   25 AC7 THR A  646  SER A  664  1                                  19    
HELIX   26 AC8 ASP A  685  ASN A  696  1                                  12    
HELIX   27 AC9 GLY A  697  GLY A  708  1                                  12    
HELIX   28 AD1 GLY A  716  TYR A  722  1                                   7    
HELIX   29 AD2 ASN A  726  ILE A  730  5                                   5    
HELIX   30 AD3 ASP A  737  LEU A  749  1                                  13    
HELIX   31 AD4 LEU A  769  ARG A  783  1                                  15    
HELIX   32 AD5 ILE A  785  TYR A  801  1                                  17    
HELIX   33 AD6 TYR A  801  VAL A  824  1                                  24    
HELIX   34 AD7 ILE A  836  LEU A  840  5                                   5    
HELIX   35 AD8 ARG A  845  VAL A  878  1                                  34    
HELIX   36 AD9 VAL A  878  LEU A  959  1                                  82    
HELIX   37 AE1 GLU B   25  ASP B   32  5                                   8    
HELIX   38 AE2 ASP B   74  VAL B   76  5                                   3    
HELIX   39 AE3 PRO B   81  ASP B   85  5                                   5    
HELIX   40 AE4 HIS B   97  SER B  111  1                                  15    
HELIX   41 AE5 GLU B  137  TYR B  142  1                                   6    
HELIX   42 AE6 ILE B  154  ARG B  169  1                                  16    
HELIX   43 AE7 GLY B  183  ALA B  199  1                                  17    
HELIX   44 AE8 GLY B  214  GLY B  231  1                                  18    
HELIX   45 AE9 LYS B  270  ILE B  274  5                                   5    
HELIX   46 AF1 HIS B  284  LYS B  293  1                                  10    
HELIX   47 AF2 LYS B  294  LEU B  301  1                                   8    
HELIX   48 AF3 ALA B  326  GLY B  340  1                                  15    
HELIX   49 AF4 THR B  342  PHE B  359  1                                  18    
HELIX   50 AF5 GLY B  360  MET B  362  5                                   3    
HELIX   51 AF6 THR B  378  GLY B  389  1                                  12    
HELIX   52 AF7 ASN B  391  LEU B  399  1                                   9    
HELIX   53 AF8 ASN B  416  LEU B  447  1                                  32    
HELIX   54 AF9 SER B  472  PHE B  494  1                                  23    
HELIX   55 AG1 PHE B  494  GLY B  505  1                                  12    
HELIX   56 AG2 ILE B  524  GLY B  529  1                                   6    
HELIX   57 AG3 SER B  532  GLU B  537  1                                   6    
HELIX   58 AG4 THR B  544  HIS B  556  1                                  13    
HELIX   59 AG5 GLY B  592  ASN B  597  1                                   6    
HELIX   60 AG6 ASN B  602  LYS B  611  1                                  10    
HELIX   61 AG7 LYS B  615  LEU B  620  1                                   6    
HELIX   62 AG8 THR B  646  SER B  664  1                                  19    
HELIX   63 AG9 ASP B  685  ASN B  696  1                                  12    
HELIX   64 AH1 GLY B  697  CYS B  705  1                                   9    
HELIX   65 AH2 TYR B  715  ARG B  723  1                                   9    
HELIX   66 AH3 ILE B  724  ASN B  726  5                                   3    
HELIX   67 AH4 GLY B  741  SER B  748  1                                   8    
HELIX   68 AH5 ASP B  752  ASN B  754  5                                   3    
HELIX   69 AH6 GLY B  768  LEU B  781  1                                  14    
HELIX   70 AH7 SER B  782  TYR B  801  1                                  20    
HELIX   71 AH8 GLU B  806  ARG B  819  1                                  14    
HELIX   72 AH9 ALA B  820  LYS B  825  1                                   6    
HELIX   73 AI1 ARG B  845  SER B  866  1                                  22    
HELIX   74 AI2 ALA B  868  LEU B  959  1                                  92    
HELIX   75 AI3 THR C   47  ASP C   62  1                                  16    
HELIX   76 AI4 GLY C   74  LEU C   83  1                                  10    
HELIX   77 AI5 THR C   88  LEU C   96  1                                   9    
HELIX   78 AI6 PHE C  111  ASN C  124  1                                  14    
HELIX   79 AI7 THR C  129  ARG C  138  1                                  10    
HELIX   80 AI8 GLY C  150  LEU C  160  1                                  11    
HELIX   81 AI9 THR C  165  MET C  173  1                                   9    
HELIX   82 AJ1 TYR C  185  SER C  195  1                                  11    
HELIX   83 AJ2 THR D   47  ASP D   62  1                                  16    
HELIX   84 AJ3 GLN D   75  GLY D   84  1                                  10    
HELIX   85 AJ4 THR D   88  VAL D   95  1                                   8    
HELIX   86 AJ5 ASP D  110  SER D  122  1                                  13    
HELIX   87 AJ6 TYR D  130  VAL D  139  1                                  10    
HELIX   88 AJ7 GLY D  150  LEU D  160  1                                  11    
HELIX   89 AJ8 THR D  165  MET D  173  1                                   9    
HELIX   90 AJ9 TYR D  185  SER D  195  1                                  11    
HELIX   91 AK1 ALA E   32  ASP E   37  1                                   6    
HELIX   92 AK2 ASP E   45  GLY E   57  1                                  13    
HELIX   93 AK3 LYS E   62  ALA E   73  1                                  12    
HELIX   94 AK4 ASN E   78  GLU E   88  1                                  11    
HELIX   95 AK5 PRO E   95  ASN E  101  1                                   7    
HELIX   96 AK6 PHE E  103  ASP E  107  5                                   5    
HELIX   97 AK7 ALA E  116  THR E  124  1                                   9    
HELIX   98 AK8 SER E  131  ALA E  141  1                                  11    
HELIX   99 AK9 LEU E  150  ILE E  159  1                                  10    
HELIX  100 AL1 GLN F   27  PHE F   33  1                                   7    
HELIX  101 AL2 THR F   34  MET F   36  5                                   3    
HELIX  102 AL3 ASP F   48  PHE F   53  1                                   6    
HELIX  103 AL4 ALA F   54  LEU F   56  5                                   3    
HELIX  104 AL5 LYS F   62  GLU F   64  5                                   3    
HELIX  105 AL6 GLU F   65  ILE F   70  1                                   6    
HELIX  106 AL7 ASN F   78  GLY F   92  1                                  15    
HELIX  107 AL8 PRO F   95  LEU F  100  1                                   6    
HELIX  108 AL9 LEU F  100  VAL F  105  1                                   6    
HELIX  109 AM1 LYS F  115  GLN F  126  1                                  12    
HELIX  110 AM2 SER F  131  PHE F  142  1                                  12    
HELIX  111 AM3 LEU F  150  HIS F  157  1                                   8    
SHEET    1 AA1 5 THR A  68  LYS A  72  0                                        
SHEET    2 AA1 5 LYS A  58  THR A  63 -1  N  ALA A  61   O  VAL A  69           
SHEET    3 AA1 5 GLU A  45  ILE A  51 -1  N  LYS A  50   O  GLU A  62           
SHEET    4 AA1 5 ASP A  36  ASP A  41 -1  N  ASP A  41   O  GLU A  45           
SHEET    5 AA1 5 MET A  77  GLN A  78 -1  O  MET A  77   N  PHE A  38           
SHEET    1 AA2 7 THR A 116  SER A 118  0                                        
SHEET    2 AA2 7 PHE A 121  VAL A 125 -1  O  PHE A 121   N  SER A 118           
SHEET    3 AA2 7 HIS A 666  ILE A 673  1  O  ARG A 671   N  CYS A 122           
SHEET    4 AA2 7 GLN A 172  THR A 177  1  N  THR A 177   O  CYS A 672           
SHEET    5 AA2 7 VAL A 459  ASP A 461  1  O  LEU A 460   N  ILE A 174           
SHEET    6 AA2 7 LYS A 246  PHE A 252 -1  N  LYS A 246   O  ASP A 461           
SHEET    7 AA2 7 LEU A 258  GLU A 264 -1  O  ASP A 262   N  ARG A 249           
SHEET    1 AA3 7 THR A 116  SER A 118  0                                        
SHEET    2 AA3 7 PHE A 121  VAL A 125 -1  O  PHE A 121   N  SER A 118           
SHEET    3 AA3 7 HIS A 666  ILE A 673  1  O  ARG A 671   N  CYS A 122           
SHEET    4 AA3 7 GLN A 172  THR A 177  1  N  THR A 177   O  CYS A 672           
SHEET    5 AA3 7 VAL A 459  ASP A 461  1  O  LEU A 460   N  ILE A 174           
SHEET    6 AA3 7 LYS A 246  PHE A 252 -1  N  LYS A 246   O  ASP A 461           
SHEET    7 AA3 7 PHE A 456  ILE A 457 -1  O  ILE A 457   N  ILE A 250           
SHEET    1 AA4 2 ARG A 403  VAL A 406  0                                        
SHEET    2 AA4 2 GLU A 409  THR A 412 -1  O  VAL A 411   N  VAL A 404           
SHEET    1 AA5 3 PHE A 563  GLN A 564  0                                        
SHEET    2 AA5 3 HIS A 576  ILE A 580 -1  O  SER A 578   N  GLN A 564           
SHEET    3 AA5 3 ILE A 585  ASN A 589 -1  O  VAL A 586   N  LEU A 579           
SHEET    1 AA6 3 ASN A 711  ILE A 713  0                                        
SHEET    2 AA6 3 VAL A 763  PHE A 765 -1  O  VAL A 763   N  ILE A 713           
SHEET    3 AA6 3 TYR A 756  PHE A 758 -1  N  LYS A 757   O  PHE A 764           
SHEET    1 AA7 5 VAL B  69  LYS B  72  0                                        
SHEET    2 AA7 5 LYS B  58  ALA B  61 -1  N  VAL B  59   O  VAL B  71           
SHEET    3 AA7 5 PHE B  46  GLU B  55 -1  N  SER B  53   O  THR B  60           
SHEET    4 AA7 5 ASP B  36  PRO B  40 -1  N  VAL B  37   O  ALA B  49           
SHEET    5 AA7 5 MET B  77  GLN B  78 -1  O  MET B  77   N  PHE B  38           
SHEET    1 AA8 7 TYR B 115  THR B 116  0                                        
SHEET    2 AA8 7 CYS B 122  VAL B 125 -1  O  VAL B 123   N  THR B 116           
SHEET    3 AA8 7 PHE B 669  ILE B 673  1  O  ILE B 673   N  THR B 124           
SHEET    4 AA8 7 GLN B 172  THR B 177  1  N  THR B 177   O  CYS B 672           
SHEET    5 AA8 7 TYR B 455  ILE B 462  1  O  GLY B 458   N  ILE B 174           
SHEET    6 AA8 7 PHE B 244  PHE B 252 -1  N  ILE B 248   O  VAL B 459           
SHEET    7 AA8 7 LEU B 258  LEU B 268 -1  O  SER B 260   N  HIS B 251           
SHEET    1 AA9 2 ASN B 232  ALA B 233  0                                        
SHEET    2 AA9 2 SER B 241  SER B 242 -1  O  SER B 241   N  ALA B 233           
SHEET    1 AB1 2 ARG B 403  VAL B 406  0                                        
SHEET    2 AB1 2 GLU B 409  THR B 412 -1  O  VAL B 411   N  VAL B 404           
SHEET    1 AB2 3 PHE B 563  GLN B 564  0                                        
SHEET    2 AB2 3 HIS B 576  LEU B 579 -1  O  SER B 578   N  GLN B 564           
SHEET    3 AB2 3 TYR B 588  ASN B 589 -1  O  TYR B 588   N  PHE B 577           
SHEET    1 AB3 3 ASN B 711  LEU B 714  0                                        
SHEET    2 AB3 3 LYS B 762  PHE B 765 -1  O  PHE B 765   N  ASN B 711           
SHEET    3 AB3 3 TYR B 756  LYS B 757 -1  N  LYS B 757   O  PHE B 764           
SHEET    1 AB4 2 LYS C  70  THR C  72  0                                        
SHEET    2 AB4 2 MET C 108  ASP C 110 -1  O  MET C 109   N  ILE C  71           
SHEET    1 AB5 2 THR C 147  MET C 149  0                                        
SHEET    2 AB5 2 CYS C 182  ASN C 184 -1  O  ILE C 183   N  VAL C 148           
SHEET    1 AB6 2 ILE D  71  THR D  72  0                                        
SHEET    2 AB6 2 MET D 108  MET D 109 -1  O  MET D 109   N  ILE D  71           
SHEET    1 AB7 2 THR D 147  MET D 149  0                                        
SHEET    2 AB7 2 CYS D 182  ASN D 184 -1  O  ILE D 183   N  VAL D 148           
SHEET    1 AB8 3 LEU E 114  LYS E 115  0                                        
SHEET    2 AB8 3 GLY E 148  ASN E 149 -1  O  ASN E 149   N  LEU E 114           
SHEET    3 AB8 3 PRO E 144  ASP E 145 -1  N  ASP E 145   O  GLY E 148           
LINK         CG  GLN A 454                 CE2 TYR B 410     1555   1555  1.08  
LINK         CD  GLN A 454                 CE2 TYR B 410     1555   1555  1.60  
LINK         NH2 ARG A 723                 NH2 ARG C 138     1555   1555  1.19  
LINK         CE1 HIS A 760                 CG  ASP B 376     1555   1555  1.20  
LINK         CE1 HIS A 760                 OD2 ASP B 376     1555   1555  1.25  
LINK         CE1 HIS A 760                 CB  ASP B 376     1555   1555  1.58  
LINK         NE  ARG A 787                 O   THR C 127     1555   1555  1.26  
LINK         CZ  ARG A 787                 N   GLY C 128     1555   1555  1.47  
LINK         CZ  ARG A 787                 C   THR C 127     1555   1555  1.40  
LINK         CD1 ILE A 788                 CD1 PHE C 133     1555   1555  1.64  
LINK         CD  LYS A 803                 CB  PRO E 108     1555   1555  1.41  
LINK         CD  LYS A 803                 CD  PRO E 108     1555   1555  1.48  
LINK         CD  LYS A 803                 CA  PRO E 108     1555   1555  1.09  
LINK         CE  LYS A 803                 C   PRO E 108     1555   1555  1.42  
LINK         CE  LYS A 803                 CB  PRO E 108     1555   1555  1.15  
LINK         NZ  LYS A 803                 CB  PRO E 108     1555   1555  1.30  
LINK         CD1 ILE A 818                 CE2 PHE E 130     1555   1555  1.64  
LINK         CD2 PHE A 834                 O   GLY E 162     1555   1555  1.45  
LINK         CD1 ILE A 836                 CD2 LEU E  56     1555   1555  1.49  
LINK         CD  ARG A 845                 NH1 ARG B 845     1555   1555  1.39  
LINK         CZ  ARG A 845                 NE  ARG B 845     1555   1555  1.47  
LINK         CZ  ARG A 845                 CD  GLN F  23     1555   1555  1.57  
LINK         NH1 ARG A 845                 OE1 GLN F  23     1555   1555  1.40  
LINK         CG  MET A 877                 CE  MET B 877     1555   1555  1.64  
LINK         CD2 LEU A 908                 CD1 LEU B 908     1555   1555  1.57  
LINK         N   GLU B 732                 OE1 GLU D 135     1555   1555  1.49  
LINK         CA  GLU B 732                 CB  GLU D 135     1555   1555  1.57  
LINK         C   GLU B 732                 CD  GLU D 135     1555   1555  1.52  
LINK         C   GLU B 732                 CB  GLU D 135     1555   1555  1.33  
LINK         CB  GLU B 732                 CB  GLU D 135     1555   1555  1.58  
LINK         N   GLY B 733                 CG  GLU D 135     1555   1555  1.32  
LINK         NH2 ARG B 787                 C   THR D 127     1555   1555  1.47  
LINK         CG  LEU B 811                 CA  PRO D  65     1555   1555  1.45  
LINK         CD2 LEU B 811                 O   THR D  64     1555   1555  1.50  
LINK         O   VAL B 824                 NH2 ARG F  58     1555   1555  1.39  
LINK         C   LYS B 825                 CZ  ARG F  58     1555   1555  1.61  
LINK         O   LYS B 825                 NE  ARG F  58     1555   1555  1.25  
LINK         O   LYS B 825                 CZ  ARG F  58     1555   1555  1.54  
LINK         N   ASN B 826                 NE  ARG F  58     1555   1555  1.23  
LINK         CA  ASN B 826                 NE  ARG F  58     1555   1555  1.59  
LINK         CZ  PHE B 834                 CB  GLU F 164     1555   1555  1.32  
CISPEP   1 GLN A  209    SER A  210          0        -0.56                     
CISPEP   2 SER A  271    ARG A  272          0        -3.58                     
CISPEP   3 GLY A  316    GLU A  317          0         9.52                     
CISPEP   4 LYS A  363    PHE A  364          0        -4.43                     
CISPEP   5 LEU A  366    LYS A  367          0       -10.42                     
CISPEP   6 GLU A  370    GLU A  371          0        -6.53                     
CISPEP   7 GLY A  425    ALA A  426          0         1.00                     
CISPEP   8 GLN A  454    TYR A  455          0        -3.01                     
CISPEP   9 PHE A  735    ILE A  736          0        20.59                     
CISPEP  10 ILE A  784    ILE A  785          0       -10.44                     
CISPEP  11 LEU B   33    LYS B   34          0       -11.08                     
CISPEP  12 LYS B  213    GLY B  214          0         6.85                     
CISPEP  13 MET B  531    SER B  532          0         3.56                     
CISPEP  14 LYS B  635    GLY B  636          0         1.42                     
CISPEP  15 ALA B  638    LYS B  639          0         1.36                     
CISPEP  16 LYS B  639    LYS B  640          0        -3.83                     
CISPEP  17 CYS C   67    GLU C   68          0        -3.30                     
CISPEP  18 GLY C  175    GLN C  176          0        -2.88                     
CISPEP  19 GLY D  175    GLN D  176          0         1.72                     
CISPEP  20 ASN D  180    GLY D  181          0         1.25                     
CISPEP  21 GLU E  109    GLY E  110          0        -1.04                     
CISPEP  22 GLU E  164    LYS E  165          0         8.87                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system