GenomeNet

Database: PDB
Entry: 6O9L
LinkDB: 6O9L
Original site: 6O9L 
HEADER    TRANSCRIPTION/DNA                       14-MAR-19   6O9L              
TITLE     HUMAN HOLO-PIC IN THE CLOSED STATE                                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1;               
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: RNA POLYMERASE II SUBUNIT B1,DNA-DIRECTED RNA POLYMERASE II 
COMPND   5 SUBUNIT A,DNA-DIRECTED RNA POLYMERASE III LARGEST SUBUNIT,RNA-       
COMPND   6 DIRECTED RNA POLYMERASE II SUBUNIT RPB1;                             
COMPND   7 EC: 2.7.7.6,2.7.7.48;                                                
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2;               
COMPND  10 CHAIN: B;                                                            
COMPND  11 SYNONYM: DNA-DIRECTED RNA POLYMERASE II 140 KDA POLYPEPTIDE,DNA-     
COMPND  12 DIRECTED RNA POLYMERASE II SUBUNIT B,RNA POLYMERASE II SUBUNIT 2,RNA 
COMPND  13 POLYMERASE II SUBUNIT B2;                                            
COMPND  14 EC: 2.7.7.6;                                                         
COMPND  15 MOL_ID: 3;                                                           
COMPND  16 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3;               
COMPND  17 CHAIN: C;                                                            
COMPND  18 SYNONYM: RNA POLYMERASE II SUBUNIT B3,DNA-DIRECTED RNA POLYMERASE II 
COMPND  19 33 KDA POLYPEPTIDE,RPB33,DNA-DIRECTED RNA POLYMERASE II SUBUNIT C,   
COMPND  20 RPB31;                                                               
COMPND  21 MOL_ID: 4;                                                           
COMPND  22 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4;               
COMPND  23 CHAIN: D;                                                            
COMPND  24 SYNONYM: RNA POLYMERASE II SUBUNIT B4,DNA-DIRECTED RNA POLYMERASE II 
COMPND  25 SUBUNIT D,RNA POLYMERASE II 16 KDA SUBUNIT,RPB16;                    
COMPND  26 MOL_ID: 5;                                                           
COMPND  27 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB5;               
COMPND  28 CHAIN: E;                                                            
COMPND  29 SYNONYM: RNA POLYMERASES I,II,AND III SUBUNIT ABC1, DNA-DIRECTED RNA 
COMPND  30 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1,          
COMPND  31 POLYMERASE II 23 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II     
COMPND  32 SUBUNIT E, XAP4;                                                     
COMPND  33 MOL_ID: 6;                                                           
COMPND  34 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2;
COMPND  35 CHAIN: F;                                                            
COMPND  36 SYNONYM: RNA POLYMERASES I,II,AND III SUBUNIT ABC2,DNA-DIRECTED RNA  
COMPND  37 POLYMERASE II SUBUNIT F,DNA-DIRECTED RNA POLYMERASES I,AND III 14.4  
COMPND  38 KDA POLYPEPTIDE,RPABC14.4,RPB14.4,RPB6 HOMOLOG,RPC15;                
COMPND  39 MOL_ID: 7;                                                           
COMPND  40 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7;               
COMPND  41 CHAIN: G;                                                            
COMPND  42 SYNONYM: RNA POLYMERASE II SUBUNIT B7,DNA-DIRECTED RNA POLYMERASE II 
COMPND  43 SUBUNIT G,RNA POLYMERASE II 19 KDA SUBUNIT,RPB19;                    
COMPND  44 MOL_ID: 8;                                                           
COMPND  45 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3;
COMPND  46 CHAIN: H;                                                            
COMPND  47 SYNONYM: RNA POLYMERASES I,II,AND III SUBUNIT ABC3,DNA-DIRECTED RNA  
COMPND  48 POLYMERASE II SUBUNIT H,DNA-DIRECTED RNA POLYMERASES I,AND III 17.1  
COMPND  49 KDA POLYPEPTIDE,RPB17,RPB8 HOMOLOG,HRPB8;                            
COMPND  50 MOL_ID: 9;                                                           
COMPND  51 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9;               
COMPND  52 CHAIN: I;                                                            
COMPND  53 SYNONYM: RNA POLYMERASE II SUBUNIT B9,DNA-DIRECTED RNA POLYMERASE II 
COMPND  54 SUBUNIT I,RNA POLYMERASE II 14.5 KDA SUBUNIT,RPB14.5;                
COMPND  55 MOL_ID: 10;                                                          
COMPND  56 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5;
COMPND  57 CHAIN: J;                                                            
COMPND  58 SYNONYM: RNA POLYMERASES I,II,AND III SUBUNIT ABC5,DNA-DIRECTED RNA  
COMPND  59 POLYMERASE III SUBUNIT L,RNA POLYMERASE II 7.6 KDA SUBUNIT,RPB7.6,   
COMPND  60 RPB10 HOMOLOG;                                                       
COMPND  61 MOL_ID: 11;                                                          
COMPND  62 MOLECULE: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-A;            
COMPND  63 CHAIN: K;                                                            
COMPND  64 SYNONYM: RPB11A,DNA-DIRECTED RNA POLYMERASE II SUBUNIT J-1,RNA       
COMPND  65 POLYMERASE II 13.3 KDA SUBUNIT;                                      
COMPND  66 MOL_ID: 12;                                                          
COMPND  67 MOLECULE: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4;
COMPND  68 CHAIN: L;                                                            
COMPND  69 SYNONYM: RNA POLYMERASES I,II,AND III SUBUNIT ABC4,ABC10-ALPHA,DNA-  
COMPND  70 DIRECTED RNA POLYMERASE II SUBUNIT K,RNA POLYMERASE II 7.0 KDA       
COMPND  71 SUBUNIT,RPB7.0,RPB10ALPHA;                                           
COMPND  72 MOL_ID: 13;                                                          
COMPND  73 MOLECULE: TRANSCRIPTION INITIATION FACTOR IIB;                       
COMPND  74 CHAIN: M;                                                            
COMPND  75 SYNONYM: GENERAL TRANSCRIPTION FACTOR TFIIB,S300-II;                 
COMPND  76 EC: 2.3.1.48;                                                        
COMPND  77 ENGINEERED: YES;                                                     
COMPND  78 MOL_ID: 14;                                                          
COMPND  79 MOLECULE: TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1;             
COMPND  80 CHAIN: N;                                                            
COMPND  81 SYNONYM: GENERAL TRANSCRIPTION FACTOR IIA SUBUNIT 1,TFIIAL,          
COMPND  82 TRANSCRIPTION INITIATION FACTOR TFIIA 42 KDA SUBUNIT,TFIIA-42;       
COMPND  83 MOL_ID: 15;                                                          
COMPND  84 MOLECULE: TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2;             
COMPND  85 CHAIN: O;                                                            
COMPND  86 SYNONYM: GENERAL TRANSCRIPTION FACTOR IIA SUBUNIT 2,TFIIA P12        
COMPND  87 SUBUNIT,TFIIAS,TRANSCRIPTION INITIATION FACTOR IIA GAMMA CHAIN,TFIIA-
COMPND  88 GAMMA;                                                               
COMPND  89 ENGINEERED: YES;                                                     
COMPND  90 MOL_ID: 16;                                                          
COMPND  91 MOLECULE: TATA-BOX-BINDING PROTEIN;                                  
COMPND  92 CHAIN: P;                                                            
COMPND  93 SYNONYM: TATA SEQUENCE-BINDING PROTEIN,TATA-BINDING FACTOR,TATA-BOX  
COMPND  94 FACTOR,TRANSCRIPTION INITIATION FACTOR TFIID TBP SUBUNIT;            
COMPND  95 ENGINEERED: YES;                                                     
COMPND  96 MOL_ID: 17;                                                          
COMPND  97 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1;                
COMPND  98 CHAIN: Q;                                                            
COMPND  99 SYNONYM: GENERAL TRANSCRIPTION FACTOR IIE 56 KDA SUBUNIT,            
COMPND 100 TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT ALPHA,TFIIE-ALPHA;       
COMPND 101 ENGINEERED: YES;                                                     
COMPND 102 MOL_ID: 18;                                                          
COMPND 103 MOLECULE: TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA;          
COMPND 104 CHAIN: R;                                                            
COMPND 105 SYNONYM: TFIIE-BETA,GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 2;      
COMPND 106 ENGINEERED: YES;                                                     
COMPND 107 MOL_ID: 19;                                                          
COMPND 108 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1;                
COMPND 109 CHAIN: S;                                                            
COMPND 110 SYNONYM: GENERAL TRANSCRIPTION FACTOR IIF 74 KDA SUBUNIT,            
COMPND 111 TRANSCRIPTION INITIATION FACTOR IIF SUBUNIT ALPHA,TFIIF-ALPHA,       
COMPND 112 TRANSCRIPTION INITIATION FACTOR RAP74;                               
COMPND 113 ENGINEERED: YES;                                                     
COMPND 114 MOL_ID: 20;                                                          
COMPND 115 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2;                
COMPND 116 CHAIN: T;                                                            
COMPND 117 SYNONYM: ATP-DEPENDENT HELICASE GTF2F2,GENERAL TRANSCRIPTION FACTOR  
COMPND 118 IIF 30 KDA SUBUNIT,TRANSCRIPTION INITIATION FACTOR IIF SUBUNIT BETA, 
COMPND 119 TFIIF-BETA,TRANSCRIPTION INITIATION FACTOR RAP30;                    
COMPND 120 EC: 3.6.4.12;                                                        
COMPND 121 ENGINEERED: YES;                                                     
COMPND 122 MOL_ID: 21;                                                          
COMPND 123 MOLECULE: TRANSCRIPTION ELONGATION FACTOR A PROTEIN 1;               
COMPND 124 CHAIN: U;                                                            
COMPND 125 SYNONYM: TRANSCRIPTION ELONGATION FACTOR S-II PROTEIN 1,             
COMPND 126 TRANSCRIPTION ELONGATION FACTOR TFIIS.O;                             
COMPND 127 MOL_ID: 22;                                                          
COMPND 128 MOLECULE: TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX HELICASE XPD      
COMPND 129 SUBUNIT;                                                             
COMPND 130 CHAIN: 0;                                                            
COMPND 131 SYNONYM: BASIC TRANSCRIPTION FACTOR 2 80 KDA SUBUNIT, BTF2 P80, CXPD,
COMPND 132 DNA EXCISION REPAIR PROTEIN ERCC-2, DNA REPAIR PROTEIN COMPLEMENTING 
COMPND 133 XP-D CELLS, TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX 80 KDA SUBUNIT, 
COMPND 134 TFIIH P80, XERODERMA PIGMENTOSUM GROUP D-COMPLEMENTING PROTEIN;      
COMPND 135 EC: 3.6.4.12;                                                        
COMPND 136 ENGINEERED: YES;                                                     
COMPND 137 MOL_ID: 23;                                                          
COMPND 138 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1;                
COMPND 139 CHAIN: 1;                                                            
COMPND 140 SYNONYM: BASIC TRANSCRIPTION FACTOR 2 62 KDA SUBUNIT,BTF2 P62,GENERAL
COMPND 141 TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1,TFIIH BASAL TRANSCRIPTION     
COMPND 142 FACTOR COMPLEX P62 SUBUNIT;                                          
COMPND 143 MOL_ID: 24;                                                          
COMPND 144 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4, P52;           
COMPND 145 CHAIN: 2;                                                            
COMPND 146 SYNONYM: BASIC TRANSCRIPTION FACTOR 2 52 KDA SUBUNIT, BTF2 P52,      
COMPND 147 GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 4, TFIIH BASAL          
COMPND 148 TRANSCRIPTION FACTOR COMPLEX P52 SUBUNIT;                            
COMPND 149 MOL_ID: 25;                                                          
COMPND 150 MOLECULE: CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1;                
COMPND 151 CHAIN: 3;                                                            
COMPND 152 SYNONYM: CDK7/CYCLIN-H ASSEMBLY FACTOR,CYCLIN-G1-INTERACTING PROTEIN,
COMPND 153 MENAGE A TROIS,RING FINGER PROTEIN 66,RING FINGER PROTEIN MAT1,P35,  
COMPND 154 P36;                                                                 
COMPND 155 MOL_ID: 26;                                                          
COMPND 156 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3;                
COMPND 157 CHAIN: 4;                                                            
COMPND 158 SYNONYM: P34, BASIC TRANSCRIPTION FACTOR 2 44 KDA SUBUNIT, BTF2 P44, 
COMPND 159 GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 2, TFIIH BASAL          
COMPND 160 TRANSCRIPTION FACTOR COMPLEX P44 SUBUNIT;                            
COMPND 161 MOL_ID: 27;                                                          
COMPND 162 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5;                
COMPND 163 CHAIN: 5;                                                            
COMPND 164 SYNONYM: GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 5, TFB5        
COMPND 165 ORTHOLOG, TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX TTD-A SUBUNIT;    
COMPND 166 MOL_ID: 28;                                                          
COMPND 167 MOLECULE: GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2;                
COMPND 168 CHAIN: 6;                                                            
COMPND 169 SYNONYM: BASIC TRANSCRIPTION FACTOR 2 44 KDA SUBUNIT, BTF2 P44,      
COMPND 170 GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 2, TFIIH BASAL          
COMPND 171 TRANSCRIPTION FACTOR COMPLEX P44 SUBUNIT;                            
COMPND 172 MOL_ID: 29;                                                          
COMPND 173 MOLECULE: TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX HELICASE XPB      
COMPND 174 SUBUNIT;                                                             
COMPND 175 CHAIN: 7;                                                            
COMPND 176 SYNONYM: BASIC TRANSCRIPTION FACTOR 2 89 KDA SUBUNIT, BTF2 P89, DNA  
COMPND 177 EXCISION REPAIR PROTEIN ERCC-3, DNA REPAIR PROTEIN COMPLEMENTING XP-B
COMPND 178 CELLS, TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX 89 KDA SUBUNIT, TFIIH
COMPND 179 P89, XERODERMA PIGMENTOSUM GROUP B-COMPLEMENTING PROTEIN;            
COMPND 180 EC: 3.6.4.12;                                                        
COMPND 181 MOL_ID: 30;                                                          
COMPND 182 MOLECULE: CYCLIN-DEPENDENT KINASE 7;                                 
COMPND 183 CHAIN: 8;                                                            
COMPND 184 SYNONYM: 39 KDA PROTEIN KINASE,P39 MO15,CDK-ACTIVATING KINASE 1,CELL 
COMPND 185 DIVISION PROTEIN KINASE 7,SERINE/THREONINE-PROTEIN KINASE 1,TFIIH    
COMPND 186 BASAL TRANSCRIPTION FACTOR COMPLEX KINASE SUBUNIT;                   
COMPND 187 EC: 2.7.11.22,2.7.11.23;                                             
COMPND 188 MOL_ID: 31;                                                          
COMPND 189 MOLECULE: CYCLIN-H;                                                  
COMPND 190 CHAIN: 9;                                                            
COMPND 191 SYNONYM: MO15-ASSOCIATED PROTEIN,P34,P37;                            
COMPND 192 MOL_ID: 32;                                                          
COMPND 193 MOLECULE: DNA (65-MER);                                              
COMPND 194 CHAIN: X;                                                            
COMPND 195 ENGINEERED: YES;                                                     
COMPND 196 MOL_ID: 33;                                                          
COMPND 197 MOLECULE: DNA (65-MER);                                              
COMPND 198 CHAIN: Y;                                                            
COMPND 199 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  15 ORGANISM_COMMON: HUMAN;                                              
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  39 ORGANISM_COMMON: HUMAN;                                              
SOURCE  40 ORGANISM_TAXID: 9606;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  47 ORGANISM_COMMON: HUMAN;                                              
SOURCE  48 ORGANISM_TAXID: 9606;                                                
SOURCE  49 MOL_ID: 13;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: GTF2B, TF2B, TFIIB;                                            
SOURCE  54 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  55 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  56 MOL_ID: 14;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  58 ORGANISM_COMMON: HUMAN;                                              
SOURCE  59 ORGANISM_TAXID: 9606;                                                
SOURCE  60 MOL_ID: 15;                                                          
SOURCE  61 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  62 ORGANISM_COMMON: HUMAN;                                              
SOURCE  63 ORGANISM_TAXID: 9606;                                                
SOURCE  64 GENE: GTF2A2, TF2A2;                                                 
SOURCE  65 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  66 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  67 MOL_ID: 16;                                                          
SOURCE  68 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  69 ORGANISM_COMMON: HUMAN;                                              
SOURCE  70 ORGANISM_TAXID: 9606;                                                
SOURCE  71 GENE: TBP, GTF2D1, TF2D, TFIID;                                      
SOURCE  72 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  73 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  74 MOL_ID: 17;                                                          
SOURCE  75 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  76 ORGANISM_COMMON: HUMAN;                                              
SOURCE  77 ORGANISM_TAXID: 9606;                                                
SOURCE  78 GENE: GTF2E1, TF2E1;                                                 
SOURCE  79 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  81 MOL_ID: 18;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 GENE: GTF2E2, TF2E2;                                                 
SOURCE  86 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  87 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  88 MOL_ID: 19;                                                          
SOURCE  89 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  90 ORGANISM_COMMON: HUMAN;                                              
SOURCE  91 ORGANISM_TAXID: 9606;                                                
SOURCE  92 GENE: GTF2F1, RAP74;                                                 
SOURCE  93 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  94 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  95 MOL_ID: 20;                                                          
SOURCE  96 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  97 ORGANISM_COMMON: HUMAN;                                              
SOURCE  98 ORGANISM_TAXID: 9606;                                                
SOURCE  99 GENE: GTF2F2, RAP30;                                                 
SOURCE 100 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 101 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE 102 MOL_ID: 21;                                                          
SOURCE 103 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 104 ORGANISM_COMMON: HUMAN;                                              
SOURCE 105 ORGANISM_TAXID: 9606;                                                
SOURCE 106 MOL_ID: 22;                                                          
SOURCE 107 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 108 ORGANISM_COMMON: HUMAN;                                              
SOURCE 109 ORGANISM_TAXID: 9606;                                                
SOURCE 110 GENE: ERCC2, XPD, XPDC;                                              
SOURCE 111 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 112 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE 113 MOL_ID: 23;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 115 ORGANISM_COMMON: HUMAN;                                              
SOURCE 116 ORGANISM_TAXID: 9606;                                                
SOURCE 117 MOL_ID: 24;                                                          
SOURCE 118 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 119 ORGANISM_COMMON: HUMAN;                                              
SOURCE 120 ORGANISM_TAXID: 9606;                                                
SOURCE 121 MOL_ID: 25;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 123 ORGANISM_COMMON: HUMAN;                                              
SOURCE 124 ORGANISM_TAXID: 9606;                                                
SOURCE 125 MOL_ID: 26;                                                          
SOURCE 126 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 127 ORGANISM_COMMON: HUMAN;                                              
SOURCE 128 ORGANISM_TAXID: 9606;                                                
SOURCE 129 MOL_ID: 27;                                                          
SOURCE 130 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 131 ORGANISM_COMMON: HUMAN;                                              
SOURCE 132 ORGANISM_TAXID: 9606;                                                
SOURCE 133 MOL_ID: 28;                                                          
SOURCE 134 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 135 ORGANISM_COMMON: HUMAN;                                              
SOURCE 136 ORGANISM_TAXID: 9606;                                                
SOURCE 137 MOL_ID: 29;                                                          
SOURCE 138 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 139 ORGANISM_COMMON: HUMAN;                                              
SOURCE 140 ORGANISM_TAXID: 9606;                                                
SOURCE 141 MOL_ID: 30;                                                          
SOURCE 142 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 143 ORGANISM_COMMON: HUMAN;                                              
SOURCE 144 ORGANISM_TAXID: 9606;                                                
SOURCE 145 MOL_ID: 31;                                                          
SOURCE 146 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 147 ORGANISM_COMMON: HUMAN;                                              
SOURCE 148 ORGANISM_TAXID: 9606;                                                
SOURCE 149 MOL_ID: 32;                                                          
SOURCE 150 SYNTHETIC: YES;                                                      
SOURCE 151 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE 152 ORGANISM_TAXID: 32630;                                               
SOURCE 153 MOL_ID: 33;                                                          
SOURCE 154 SYNTHETIC: YES;                                                      
SOURCE 155 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE 156 ORGANISM_TAXID: 32630                                                
KEYWDS    TRANSCRIPTION INITIATION, MOLECULAR DYNAMICS, GENE REGULATION,        
KEYWDS   2 COMMUNITY NETWORK ANALYSIS, GLOBAL PROTEIN DYNAMICS, RNA POLYMERASE, 
KEYWDS   3 TRANSCRIPTION-DNA COMPLEX                                            
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.L.YAN,T.DODD,Y.HE,J.A.TAINER,S.E.TSUTAKAWA,I.IVANOV                 
REVDAT   4   01-JAN-20 6O9L    1       REMARK                                   
REVDAT   3   19-JUN-19 6O9L    1       JRNL                                     
REVDAT   2   05-JUN-19 6O9L    1       JRNL                                     
REVDAT   1   29-MAY-19 6O9L    0                                                
JRNL        AUTH   C.YAN,T.DODD,Y.HE,J.A.TAINER,S.E.TSUTAKAWA,I.IVANOV          
JRNL        TITL   TRANSCRIPTION PREINITIATION COMPLEX STRUCTURE AND DYNAMICS   
JRNL        TITL 2 PROVIDE INSIGHT INTO GENETIC DISEASES.                       
JRNL        REF    NAT.STRUCT.MOL.BIOL.          V.  26   397 2019              
JRNL        REFN                   ESSN 1545-9985                               
JRNL        PMID   31110295                                                     
JRNL        DOI    10.1038/S41594-019-0220-3                                    
REMARK   0                                                                      
REMARK   0 ORIGINAL DATA REFERENCE 1                                            
REMARK   0  AUTH   R.K.LOUDER,Y.HE,J.R.LOPEZ-BLANCO,J.FANG,P.CHACON,E.NOGALES   
REMARK   0  TITL   STRUCTURE OF PROMOTER-BOUND TFIID AND MODEL OF HUMAN         
REMARK   0  TITL 2 PRE-INITIATION COMPLEX ASSEMBLY.                             
REMARK   0  REF    NATURE                        V. 531   604 2016              
REMARK   0  REFN                   ESSN 1476-4687                               
REMARK   0  PMID   27007846                                                     
REMARK   0  DOI    10.1038/NATURE17394                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.20 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NAMD, UCSF CHIMERA, COOT, PHENIX          
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : OTHER                               
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : INITIAL MODEL ASSEMBLED FROM HIGH-RESOLUTION     
REMARK   3  STRUCTURES AND HOMOLOGY MODELS, SUBSEQUENTLY REBUILT IN COOT,       
REMARK   3  REFINED INTO THE CRYO-EM MAP USING PHENIX AND FULLY VALIDATED.      
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 7.200                          
REMARK   3   NUMBER OF PARTICLES               : 24290                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6O9L COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB.                               
REMARK 100 THE DEPOSITION ID IS D_1000240266.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : NULL                              
REMARK 245   NAME OF SAMPLE                 : HOLO-PIC IN THE CLOSED STATE      
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : NULL                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN                      
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 46.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 33-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 33-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 184510 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 497050 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -1132.0 KCAL/MOL                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: T, U, 0, 1, 2, 3, 4, 5, 6, 7,         
REMARK 350                    AND CHAINS: 8, 9, X, Y                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     HIS A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     GLY A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     SER A     8                                                      
REMARK 465     GLY A     9                                                      
REMARK 465     ILE A  1486                                                      
REMARK 465     PRO A  1487                                                      
REMARK 465     THR A  1488                                                      
REMARK 465     ASN A  1489                                                      
REMARK 465     ILE A  1490                                                      
REMARK 465     PRO A  1491                                                      
REMARK 465     GLY A  1492                                                      
REMARK 465     LEU A  1493                                                      
REMARK 465     GLY A  1494                                                      
REMARK 465     ALA A  1495                                                      
REMARK 465     ALA A  1496                                                      
REMARK 465     GLY A  1497                                                      
REMARK 465     PRO A  1498                                                      
REMARK 465     THR A  1499                                                      
REMARK 465     GLY A  1500                                                      
REMARK 465     MET A  1501                                                      
REMARK 465     PHE A  1502                                                      
REMARK 465     PHE A  1503                                                      
REMARK 465     GLY A  1504                                                      
REMARK 465     SER A  1505                                                      
REMARK 465     ALA A  1506                                                      
REMARK 465     PRO A  1507                                                      
REMARK 465     SER A  1508                                                      
REMARK 465     PRO A  1509                                                      
REMARK 465     MET A  1510                                                      
REMARK 465     GLY A  1511                                                      
REMARK 465     GLY A  1512                                                      
REMARK 465     ILE A  1513                                                      
REMARK 465     SER A  1514                                                      
REMARK 465     PRO A  1515                                                      
REMARK 465     ALA A  1516                                                      
REMARK 465     MET A  1517                                                      
REMARK 465     THR A  1518                                                      
REMARK 465     PRO A  1519                                                      
REMARK 465     TRP A  1520                                                      
REMARK 465     ASN A  1521                                                      
REMARK 465     GLN A  1522                                                      
REMARK 465     GLY A  1523                                                      
REMARK 465     ALA A  1524                                                      
REMARK 465     THR A  1525                                                      
REMARK 465     PRO A  1526                                                      
REMARK 465     ALA A  1527                                                      
REMARK 465     TYR A  1528                                                      
REMARK 465     GLY A  1529                                                      
REMARK 465     ALA A  1530                                                      
REMARK 465     TRP A  1531                                                      
REMARK 465     SER A  1532                                                      
REMARK 465     PRO A  1533                                                      
REMARK 465     SER A  1534                                                      
REMARK 465     VAL A  1535                                                      
REMARK 465     GLY A  1536                                                      
REMARK 465     SER A  1537                                                      
REMARK 465     GLY A  1538                                                      
REMARK 465     MET A  1539                                                      
REMARK 465     THR A  1540                                                      
REMARK 465     PRO A  1541                                                      
REMARK 465     GLY A  1542                                                      
REMARK 465     ALA A  1543                                                      
REMARK 465     ALA A  1544                                                      
REMARK 465     GLY A  1545                                                      
REMARK 465     PHE A  1546                                                      
REMARK 465     SER A  1547                                                      
REMARK 465     PRO A  1548                                                      
REMARK 465     SER A  1549                                                      
REMARK 465     ALA A  1550                                                      
REMARK 465     ALA A  1551                                                      
REMARK 465     SER A  1552                                                      
REMARK 465     ASP A  1553                                                      
REMARK 465     ALA A  1554                                                      
REMARK 465     SER A  1555                                                      
REMARK 465     GLY A  1556                                                      
REMARK 465     PHE A  1557                                                      
REMARK 465     SER A  1558                                                      
REMARK 465     PRO A  1559                                                      
REMARK 465     GLY A  1560                                                      
REMARK 465     TYR A  1561                                                      
REMARK 465     SER A  1562                                                      
REMARK 465     PRO A  1563                                                      
REMARK 465     ALA A  1564                                                      
REMARK 465     TRP A  1565                                                      
REMARK 465     SER A  1566                                                      
REMARK 465     PRO A  1567                                                      
REMARK 465     THR A  1568                                                      
REMARK 465     PRO A  1569                                                      
REMARK 465     GLY A  1570                                                      
REMARK 465     SER A  1571                                                      
REMARK 465     PRO A  1572                                                      
REMARK 465     GLY A  1573                                                      
REMARK 465     SER A  1574                                                      
REMARK 465     PRO A  1575                                                      
REMARK 465     GLY A  1576                                                      
REMARK 465     PRO A  1577                                                      
REMARK 465     SER A  1578                                                      
REMARK 465     SER A  1579                                                      
REMARK 465     PRO A  1580                                                      
REMARK 465     TYR A  1581                                                      
REMARK 465     ILE A  1582                                                      
REMARK 465     PRO A  1583                                                      
REMARK 465     SER A  1584                                                      
REMARK 465     PRO A  1585                                                      
REMARK 465     GLY A  1586                                                      
REMARK 465     GLY A  1587                                                      
REMARK 465     ALA A  1588                                                      
REMARK 465     MET A  1589                                                      
REMARK 465     SER A  1590                                                      
REMARK 465     PRO A  1591                                                      
REMARK 465     SER A  1592                                                      
REMARK 465     TYR A  1593                                                      
REMARK 465     SER A  1594                                                      
REMARK 465     PRO A  1595                                                      
REMARK 465     THR A  1596                                                      
REMARK 465     SER A  1597                                                      
REMARK 465     PRO A  1598                                                      
REMARK 465     ALA A  1599                                                      
REMARK 465     TYR A  1600                                                      
REMARK 465     GLU A  1601                                                      
REMARK 465     PRO A  1602                                                      
REMARK 465     ARG A  1603                                                      
REMARK 465     SER A  1604                                                      
REMARK 465     PRO A  1605                                                      
REMARK 465     GLY A  1606                                                      
REMARK 465     GLY A  1607                                                      
REMARK 465     TYR A  1608                                                      
REMARK 465     THR A  1609                                                      
REMARK 465     PRO A  1610                                                      
REMARK 465     GLN A  1611                                                      
REMARK 465     SER A  1612                                                      
REMARK 465     PRO A  1613                                                      
REMARK 465     SER A  1614                                                      
REMARK 465     TYR A  1615                                                      
REMARK 465     SER A  1616                                                      
REMARK 465     PRO A  1617                                                      
REMARK 465     THR A  1618                                                      
REMARK 465     SER A  1619                                                      
REMARK 465     PRO A  1620                                                      
REMARK 465     SER A  1621                                                      
REMARK 465     TYR A  1622                                                      
REMARK 465     SER A  1623                                                      
REMARK 465     PRO A  1624                                                      
REMARK 465     THR A  1625                                                      
REMARK 465     SER A  1626                                                      
REMARK 465     PRO A  1627                                                      
REMARK 465     SER A  1628                                                      
REMARK 465     TYR A  1629                                                      
REMARK 465     SER A  1630                                                      
REMARK 465     PRO A  1631                                                      
REMARK 465     THR A  1632                                                      
REMARK 465     SER A  1633                                                      
REMARK 465     PRO A  1634                                                      
REMARK 465     ASN A  1635                                                      
REMARK 465     TYR A  1636                                                      
REMARK 465     SER A  1637                                                      
REMARK 465     PRO A  1638                                                      
REMARK 465     THR A  1639                                                      
REMARK 465     SER A  1640                                                      
REMARK 465     PRO A  1641                                                      
REMARK 465     SER A  1642                                                      
REMARK 465     TYR A  1643                                                      
REMARK 465     SER A  1644                                                      
REMARK 465     PRO A  1645                                                      
REMARK 465     THR A  1646                                                      
REMARK 465     SER A  1647                                                      
REMARK 465     PRO A  1648                                                      
REMARK 465     SER A  1649                                                      
REMARK 465     TYR A  1650                                                      
REMARK 465     SER A  1651                                                      
REMARK 465     PRO A  1652                                                      
REMARK 465     THR A  1653                                                      
REMARK 465     SER A  1654                                                      
REMARK 465     PRO A  1655                                                      
REMARK 465     SER A  1656                                                      
REMARK 465     TYR A  1657                                                      
REMARK 465     SER A  1658                                                      
REMARK 465     PRO A  1659                                                      
REMARK 465     THR A  1660                                                      
REMARK 465     SER A  1661                                                      
REMARK 465     PRO A  1662                                                      
REMARK 465     SER A  1663                                                      
REMARK 465     TYR A  1664                                                      
REMARK 465     SER A  1665                                                      
REMARK 465     PRO A  1666                                                      
REMARK 465     THR A  1667                                                      
REMARK 465     SER A  1668                                                      
REMARK 465     PRO A  1669                                                      
REMARK 465     SER A  1670                                                      
REMARK 465     TYR A  1671                                                      
REMARK 465     SER A  1672                                                      
REMARK 465     PRO A  1673                                                      
REMARK 465     THR A  1674                                                      
REMARK 465     SER A  1675                                                      
REMARK 465     PRO A  1676                                                      
REMARK 465     SER A  1677                                                      
REMARK 465     TYR A  1678                                                      
REMARK 465     SER A  1679                                                      
REMARK 465     PRO A  1680                                                      
REMARK 465     THR A  1681                                                      
REMARK 465     SER A  1682                                                      
REMARK 465     PRO A  1683                                                      
REMARK 465     SER A  1684                                                      
REMARK 465     TYR A  1685                                                      
REMARK 465     SER A  1686                                                      
REMARK 465     PRO A  1687                                                      
REMARK 465     THR A  1688                                                      
REMARK 465     SER A  1689                                                      
REMARK 465     PRO A  1690                                                      
REMARK 465     SER A  1691                                                      
REMARK 465     TYR A  1692                                                      
REMARK 465     SER A  1693                                                      
REMARK 465     PRO A  1694                                                      
REMARK 465     THR A  1695                                                      
REMARK 465     SER A  1696                                                      
REMARK 465     PRO A  1697                                                      
REMARK 465     SER A  1698                                                      
REMARK 465     TYR A  1699                                                      
REMARK 465     SER A  1700                                                      
REMARK 465     PRO A  1701                                                      
REMARK 465     THR A  1702                                                      
REMARK 465     SER A  1703                                                      
REMARK 465     PRO A  1704                                                      
REMARK 465     SER A  1705                                                      
REMARK 465     TYR A  1706                                                      
REMARK 465     SER A  1707                                                      
REMARK 465     PRO A  1708                                                      
REMARK 465     THR A  1709                                                      
REMARK 465     SER A  1710                                                      
REMARK 465     PRO A  1711                                                      
REMARK 465     SER A  1712                                                      
REMARK 465     TYR A  1713                                                      
REMARK 465     SER A  1714                                                      
REMARK 465     PRO A  1715                                                      
REMARK 465     THR A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     PRO A  1718                                                      
REMARK 465     SER A  1719                                                      
REMARK 465     TYR A  1720                                                      
REMARK 465     SER A  1721                                                      
REMARK 465     PRO A  1722                                                      
REMARK 465     THR A  1723                                                      
REMARK 465     SER A  1724                                                      
REMARK 465     PRO A  1725                                                      
REMARK 465     SER A  1726                                                      
REMARK 465     TYR A  1727                                                      
REMARK 465     SER A  1728                                                      
REMARK 465     PRO A  1729                                                      
REMARK 465     THR A  1730                                                      
REMARK 465     SER A  1731                                                      
REMARK 465     PRO A  1732                                                      
REMARK 465     SER A  1733                                                      
REMARK 465     TYR A  1734                                                      
REMARK 465     SER A  1735                                                      
REMARK 465     PRO A  1736                                                      
REMARK 465     THR A  1737                                                      
REMARK 465     SER A  1738                                                      
REMARK 465     PRO A  1739                                                      
REMARK 465     SER A  1740                                                      
REMARK 465     TYR A  1741                                                      
REMARK 465     SER A  1742                                                      
REMARK 465     PRO A  1743                                                      
REMARK 465     THR A  1744                                                      
REMARK 465     SER A  1745                                                      
REMARK 465     PRO A  1746                                                      
REMARK 465     ASN A  1747                                                      
REMARK 465     TYR A  1748                                                      
REMARK 465     SER A  1749                                                      
REMARK 465     PRO A  1750                                                      
REMARK 465     THR A  1751                                                      
REMARK 465     SER A  1752                                                      
REMARK 465     PRO A  1753                                                      
REMARK 465     ASN A  1754                                                      
REMARK 465     TYR A  1755                                                      
REMARK 465     THR A  1756                                                      
REMARK 465     PRO A  1757                                                      
REMARK 465     THR A  1758                                                      
REMARK 465     SER A  1759                                                      
REMARK 465     PRO A  1760                                                      
REMARK 465     SER A  1761                                                      
REMARK 465     TYR A  1762                                                      
REMARK 465     SER A  1763                                                      
REMARK 465     PRO A  1764                                                      
REMARK 465     THR A  1765                                                      
REMARK 465     SER A  1766                                                      
REMARK 465     PRO A  1767                                                      
REMARK 465     SER A  1768                                                      
REMARK 465     TYR A  1769                                                      
REMARK 465     SER A  1770                                                      
REMARK 465     PRO A  1771                                                      
REMARK 465     THR A  1772                                                      
REMARK 465     SER A  1773                                                      
REMARK 465     PRO A  1774                                                      
REMARK 465     ASN A  1775                                                      
REMARK 465     TYR A  1776                                                      
REMARK 465     THR A  1777                                                      
REMARK 465     PRO A  1778                                                      
REMARK 465     THR A  1779                                                      
REMARK 465     SER A  1780                                                      
REMARK 465     PRO A  1781                                                      
REMARK 465     ASN A  1782                                                      
REMARK 465     TYR A  1783                                                      
REMARK 465     SER A  1784                                                      
REMARK 465     PRO A  1785                                                      
REMARK 465     THR A  1786                                                      
REMARK 465     SER A  1787                                                      
REMARK 465     PRO A  1788                                                      
REMARK 465     SER A  1789                                                      
REMARK 465     TYR A  1790                                                      
REMARK 465     SER A  1791                                                      
REMARK 465     PRO A  1792                                                      
REMARK 465     THR A  1793                                                      
REMARK 465     SER A  1794                                                      
REMARK 465     PRO A  1795                                                      
REMARK 465     SER A  1796                                                      
REMARK 465     TYR A  1797                                                      
REMARK 465     SER A  1798                                                      
REMARK 465     PRO A  1799                                                      
REMARK 465     THR A  1800                                                      
REMARK 465     SER A  1801                                                      
REMARK 465     PRO A  1802                                                      
REMARK 465     SER A  1803                                                      
REMARK 465     TYR A  1804                                                      
REMARK 465     SER A  1805                                                      
REMARK 465     PRO A  1806                                                      
REMARK 465     SER A  1807                                                      
REMARK 465     SER A  1808                                                      
REMARK 465     PRO A  1809                                                      
REMARK 465     ARG A  1810                                                      
REMARK 465     TYR A  1811                                                      
REMARK 465     THR A  1812                                                      
REMARK 465     PRO A  1813                                                      
REMARK 465     GLN A  1814                                                      
REMARK 465     SER A  1815                                                      
REMARK 465     PRO A  1816                                                      
REMARK 465     THR A  1817                                                      
REMARK 465     TYR A  1818                                                      
REMARK 465     THR A  1819                                                      
REMARK 465     PRO A  1820                                                      
REMARK 465     SER A  1821                                                      
REMARK 465     SER A  1822                                                      
REMARK 465     PRO A  1823                                                      
REMARK 465     SER A  1824                                                      
REMARK 465     TYR A  1825                                                      
REMARK 465     SER A  1826                                                      
REMARK 465     PRO A  1827                                                      
REMARK 465     SER A  1828                                                      
REMARK 465     SER A  1829                                                      
REMARK 465     PRO A  1830                                                      
REMARK 465     SER A  1831                                                      
REMARK 465     TYR A  1832                                                      
REMARK 465     SER A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     ALA A  1835                                                      
REMARK 465     SER A  1836                                                      
REMARK 465     PRO A  1837                                                      
REMARK 465     LYS A  1838                                                      
REMARK 465     TYR A  1839                                                      
REMARK 465     THR A  1840                                                      
REMARK 465     PRO A  1841                                                      
REMARK 465     THR A  1842                                                      
REMARK 465     SER A  1843                                                      
REMARK 465     PRO A  1844                                                      
REMARK 465     SER A  1845                                                      
REMARK 465     TYR A  1846                                                      
REMARK 465     SER A  1847                                                      
REMARK 465     PRO A  1848                                                      
REMARK 465     SER A  1849                                                      
REMARK 465     SER A  1850                                                      
REMARK 465     PRO A  1851                                                      
REMARK 465     GLU A  1852                                                      
REMARK 465     TYR A  1853                                                      
REMARK 465     THR A  1854                                                      
REMARK 465     PRO A  1855                                                      
REMARK 465     THR A  1856                                                      
REMARK 465     SER A  1857                                                      
REMARK 465     PRO A  1858                                                      
REMARK 465     LYS A  1859                                                      
REMARK 465     TYR A  1860                                                      
REMARK 465     SER A  1861                                                      
REMARK 465     PRO A  1862                                                      
REMARK 465     THR A  1863                                                      
REMARK 465     SER A  1864                                                      
REMARK 465     PRO A  1865                                                      
REMARK 465     LYS A  1866                                                      
REMARK 465     TYR A  1867                                                      
REMARK 465     SER A  1868                                                      
REMARK 465     PRO A  1869                                                      
REMARK 465     THR A  1870                                                      
REMARK 465     SER A  1871                                                      
REMARK 465     PRO A  1872                                                      
REMARK 465     LYS A  1873                                                      
REMARK 465     TYR A  1874                                                      
REMARK 465     SER A  1875                                                      
REMARK 465     PRO A  1876                                                      
REMARK 465     THR A  1877                                                      
REMARK 465     SER A  1878                                                      
REMARK 465     PRO A  1879                                                      
REMARK 465     THR A  1880                                                      
REMARK 465     TYR A  1881                                                      
REMARK 465     SER A  1882                                                      
REMARK 465     PRO A  1883                                                      
REMARK 465     THR A  1884                                                      
REMARK 465     THR A  1885                                                      
REMARK 465     PRO A  1886                                                      
REMARK 465     LYS A  1887                                                      
REMARK 465     TYR A  1888                                                      
REMARK 465     SER A  1889                                                      
REMARK 465     PRO A  1890                                                      
REMARK 465     THR A  1891                                                      
REMARK 465     SER A  1892                                                      
REMARK 465     PRO A  1893                                                      
REMARK 465     THR A  1894                                                      
REMARK 465     TYR A  1895                                                      
REMARK 465     SER A  1896                                                      
REMARK 465     PRO A  1897                                                      
REMARK 465     THR A  1898                                                      
REMARK 465     SER A  1899                                                      
REMARK 465     PRO A  1900                                                      
REMARK 465     VAL A  1901                                                      
REMARK 465     TYR A  1902                                                      
REMARK 465     THR A  1903                                                      
REMARK 465     PRO A  1904                                                      
REMARK 465     THR A  1905                                                      
REMARK 465     SER A  1906                                                      
REMARK 465     PRO A  1907                                                      
REMARK 465     LYS A  1908                                                      
REMARK 465     TYR A  1909                                                      
REMARK 465     SER A  1910                                                      
REMARK 465     PRO A  1911                                                      
REMARK 465     THR A  1912                                                      
REMARK 465     SER A  1913                                                      
REMARK 465     PRO A  1914                                                      
REMARK 465     THR A  1915                                                      
REMARK 465     TYR A  1916                                                      
REMARK 465     SER A  1917                                                      
REMARK 465     PRO A  1918                                                      
REMARK 465     THR A  1919                                                      
REMARK 465     SER A  1920                                                      
REMARK 465     PRO A  1921                                                      
REMARK 465     LYS A  1922                                                      
REMARK 465     TYR A  1923                                                      
REMARK 465     SER A  1924                                                      
REMARK 465     PRO A  1925                                                      
REMARK 465     THR A  1926                                                      
REMARK 465     SER A  1927                                                      
REMARK 465     PRO A  1928                                                      
REMARK 465     THR A  1929                                                      
REMARK 465     TYR A  1930                                                      
REMARK 465     SER A  1931                                                      
REMARK 465     PRO A  1932                                                      
REMARK 465     THR A  1933                                                      
REMARK 465     SER A  1934                                                      
REMARK 465     PRO A  1935                                                      
REMARK 465     LYS A  1936                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     SER A  1938                                                      
REMARK 465     THR A  1939                                                      
REMARK 465     TYR A  1940                                                      
REMARK 465     SER A  1941                                                      
REMARK 465     PRO A  1942                                                      
REMARK 465     THR A  1943                                                      
REMARK 465     SER A  1944                                                      
REMARK 465     PRO A  1945                                                      
REMARK 465     GLY A  1946                                                      
REMARK 465     TYR A  1947                                                      
REMARK 465     SER A  1948                                                      
REMARK 465     PRO A  1949                                                      
REMARK 465     THR A  1950                                                      
REMARK 465     SER A  1951                                                      
REMARK 465     PRO A  1952                                                      
REMARK 465     THR A  1953                                                      
REMARK 465     TYR A  1954                                                      
REMARK 465     SER A  1955                                                      
REMARK 465     LEU A  1956                                                      
REMARK 465     THR A  1957                                                      
REMARK 465     SER A  1958                                                      
REMARK 465     PRO A  1959                                                      
REMARK 465     ALA A  1960                                                      
REMARK 465     ILE A  1961                                                      
REMARK 465     SER A  1962                                                      
REMARK 465     PRO A  1963                                                      
REMARK 465     ASP A  1964                                                      
REMARK 465     ASP A  1965                                                      
REMARK 465     SER A  1966                                                      
REMARK 465     ASP A  1967                                                      
REMARK 465     GLU A  1968                                                      
REMARK 465     GLU A  1969                                                      
REMARK 465     ASN A  1970                                                      
REMARK 465     MET B     1                                                      
REMARK 465     TYR B     2                                                      
REMARK 465     ASP B     3                                                      
REMARK 465     ALA B     4                                                      
REMARK 465     ASP B     5                                                      
REMARK 465     GLU B     6                                                      
REMARK 465     ASP B     7                                                      
REMARK 465     MET B     8                                                      
REMARK 465     GLN B     9                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     ALA D     3                                                      
REMARK 465     GLY D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     SER D     6                                                      
REMARK 465     ASP D     7                                                      
REMARK 465     PRO D     8                                                      
REMARK 465     ARG D     9                                                      
REMARK 465     ALA D    10                                                      
REMARK 465     GLY D    11                                                      
REMARK 465     ASP D    12                                                      
REMARK 465     VAL D    13                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     ASP F     3                                                      
REMARK 465     ASN F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     ASP F     6                                                      
REMARK 465     ASN F     7                                                      
REMARK 465     PHE F     8                                                      
REMARK 465     ASP F     9                                                      
REMARK 465     GLY F    10                                                      
REMARK 465     ASP F    11                                                      
REMARK 465     ASP F    12                                                      
REMARK 465     PHE F    13                                                      
REMARK 465     ASP F    14                                                      
REMARK 465     ASP F    15                                                      
REMARK 465     VAL F    16                                                      
REMARK 465     GLU F    17                                                      
REMARK 465     GLU F    18                                                      
REMARK 465     ASP F    19                                                      
REMARK 465     GLU F    20                                                      
REMARK 465     GLY F    21                                                      
REMARK 465     LEU F    22                                                      
REMARK 465     ASP F    23                                                      
REMARK 465     ASP F    24                                                      
REMARK 465     LEU F    25                                                      
REMARK 465     GLU F    26                                                      
REMARK 465     ASN F    27                                                      
REMARK 465     ALA F    28                                                      
REMARK 465     GLU F    29                                                      
REMARK 465     GLU F    30                                                      
REMARK 465     GLU F    31                                                      
REMARK 465     GLY F    32                                                      
REMARK 465     GLN F    33                                                      
REMARK 465     GLU F    34                                                      
REMARK 465     ASN F    35                                                      
REMARK 465     VAL F    36                                                      
REMARK 465     GLU F    37                                                      
REMARK 465     ILE F    38                                                      
REMARK 465     LEU F    39                                                      
REMARK 465     PRO F    40                                                      
REMARK 465     SER F    41                                                      
REMARK 465     SER G   172                                                      
REMARK 465     MET L     1                                                      
REMARK 465     ASP L     2                                                      
REMARK 465     THR L     3                                                      
REMARK 465     GLN L     4                                                      
REMARK 465     LYS L     5                                                      
REMARK 465     ASP L     6                                                      
REMARK 465     VAL L     7                                                      
REMARK 465     GLN L     8                                                      
REMARK 465     PRO L     9                                                      
REMARK 465     PRO L    10                                                      
REMARK 465     LYS L    11                                                      
REMARK 465     GLN L    12                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     SER M     3                                                      
REMARK 465     THR M     4                                                      
REMARK 465     SER M     5                                                      
REMARK 465     ARG M     6                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ASN N     3                                                      
REMARK 465     SER N     4                                                      
REMARK 465     ALA N     5                                                      
REMARK 465     ASN N     6                                                      
REMARK 465     THR N     7                                                      
REMARK 465     ASN N     8                                                      
REMARK 465     GLN N    52                                                      
REMARK 465     SER N    53                                                      
REMARK 465     ARG N    54                                                      
REMARK 465     ALA N    55                                                      
REMARK 465     VAL N    56                                                      
REMARK 465     ASP N    57                                                      
REMARK 465     GLY N    58                                                      
REMARK 465     PHE N    59                                                      
REMARK 465     HIS N    60                                                      
REMARK 465     SER N    61                                                      
REMARK 465     GLU N    62                                                      
REMARK 465     GLU N    63                                                      
REMARK 465     GLN N    64                                                      
REMARK 465     GLN N    65                                                      
REMARK 465     LEU N    66                                                      
REMARK 465     LEU N    67                                                      
REMARK 465     LEU N    68                                                      
REMARK 465     GLN N    69                                                      
REMARK 465     VAL N    70                                                      
REMARK 465     GLN N    71                                                      
REMARK 465     GLN N    72                                                      
REMARK 465     GLN N    73                                                      
REMARK 465     HIS N    74                                                      
REMARK 465     GLN N    75                                                      
REMARK 465     PRO N    76                                                      
REMARK 465     GLN N    77                                                      
REMARK 465     GLN N    78                                                      
REMARK 465     GLN N    79                                                      
REMARK 465     GLN N    80                                                      
REMARK 465     HIS N    81                                                      
REMARK 465     HIS N    82                                                      
REMARK 465     HIS N    83                                                      
REMARK 465     HIS N    84                                                      
REMARK 465     HIS N    85                                                      
REMARK 465     HIS N    86                                                      
REMARK 465     HIS N    87                                                      
REMARK 465     GLN N    88                                                      
REMARK 465     GLN N    89                                                      
REMARK 465     ALA N    90                                                      
REMARK 465     GLN N    91                                                      
REMARK 465     PRO N    92                                                      
REMARK 465     GLN N    93                                                      
REMARK 465     GLN N    94                                                      
REMARK 465     THR N    95                                                      
REMARK 465     VAL N    96                                                      
REMARK 465     PRO N    97                                                      
REMARK 465     GLN N    98                                                      
REMARK 465     GLN N    99                                                      
REMARK 465     ALA N   100                                                      
REMARK 465     GLN N   101                                                      
REMARK 465     THR N   102                                                      
REMARK 465     GLN N   103                                                      
REMARK 465     GLN N   104                                                      
REMARK 465     VAL N   105                                                      
REMARK 465     LEU N   106                                                      
REMARK 465     ILE N   107                                                      
REMARK 465     PRO N   108                                                      
REMARK 465     ALA N   109                                                      
REMARK 465     SER N   110                                                      
REMARK 465     GLN N   111                                                      
REMARK 465     GLN N   112                                                      
REMARK 465     ALA N   113                                                      
REMARK 465     THR N   114                                                      
REMARK 465     ALA N   115                                                      
REMARK 465     PRO N   116                                                      
REMARK 465     GLN N   117                                                      
REMARK 465     VAL N   118                                                      
REMARK 465     ILE N   119                                                      
REMARK 465     VAL N   120                                                      
REMARK 465     PRO N   121                                                      
REMARK 465     ASP N   122                                                      
REMARK 465     SER N   123                                                      
REMARK 465     LYS N   124                                                      
REMARK 465     LEU N   125                                                      
REMARK 465     ILE N   126                                                      
REMARK 465     GLN N   127                                                      
REMARK 465     HIS N   128                                                      
REMARK 465     MET N   129                                                      
REMARK 465     ASN N   130                                                      
REMARK 465     ALA N   131                                                      
REMARK 465     SER N   132                                                      
REMARK 465     ASN N   133                                                      
REMARK 465     MET N   134                                                      
REMARK 465     SER N   135                                                      
REMARK 465     ALA N   136                                                      
REMARK 465     ALA N   137                                                      
REMARK 465     ALA N   138                                                      
REMARK 465     THR N   139                                                      
REMARK 465     ALA N   140                                                      
REMARK 465     ALA N   141                                                      
REMARK 465     THR N   142                                                      
REMARK 465     LEU N   143                                                      
REMARK 465     ALA N   144                                                      
REMARK 465     LEU N   145                                                      
REMARK 465     PRO N   146                                                      
REMARK 465     ALA N   147                                                      
REMARK 465     GLY N   148                                                      
REMARK 465     VAL N   149                                                      
REMARK 465     THR N   150                                                      
REMARK 465     PRO N   151                                                      
REMARK 465     VAL N   152                                                      
REMARK 465     GLN N   153                                                      
REMARK 465     GLN N   154                                                      
REMARK 465     ILE N   155                                                      
REMARK 465     LEU N   156                                                      
REMARK 465     THR N   157                                                      
REMARK 465     ASN N   158                                                      
REMARK 465     SER N   159                                                      
REMARK 465     GLY N   160                                                      
REMARK 465     GLN N   161                                                      
REMARK 465     LEU N   162                                                      
REMARK 465     LEU N   163                                                      
REMARK 465     GLN N   164                                                      
REMARK 465     VAL N   165                                                      
REMARK 465     VAL N   166                                                      
REMARK 465     ARG N   167                                                      
REMARK 465     ALA N   168                                                      
REMARK 465     ALA N   169                                                      
REMARK 465     ASN N   170                                                      
REMARK 465     GLY N   171                                                      
REMARK 465     ALA N   172                                                      
REMARK 465     GLN N   173                                                      
REMARK 465     TYR N   174                                                      
REMARK 465     ILE N   175                                                      
REMARK 465     PHE N   176                                                      
REMARK 465     GLN N   177                                                      
REMARK 465     PRO N   178                                                      
REMARK 465     GLN N   179                                                      
REMARK 465     GLN N   180                                                      
REMARK 465     SER N   181                                                      
REMARK 465     VAL N   182                                                      
REMARK 465     VAL N   183                                                      
REMARK 465     LEU N   184                                                      
REMARK 465     GLN N   185                                                      
REMARK 465     GLN N   186                                                      
REMARK 465     GLN N   187                                                      
REMARK 465     VAL N   188                                                      
REMARK 465     ILE N   189                                                      
REMARK 465     PRO N   190                                                      
REMARK 465     GLN N   191                                                      
REMARK 465     MET N   192                                                      
REMARK 465     GLN N   193                                                      
REMARK 465     PRO N   194                                                      
REMARK 465     GLY N   195                                                      
REMARK 465     GLY N   196                                                      
REMARK 465     VAL N   197                                                      
REMARK 465     GLN N   198                                                      
REMARK 465     ALA N   199                                                      
REMARK 465     PRO N   200                                                      
REMARK 465     VAL N   201                                                      
REMARK 465     ILE N   202                                                      
REMARK 465     GLN N   203                                                      
REMARK 465     GLN N   204                                                      
REMARK 465     VAL N   205                                                      
REMARK 465     LEU N   206                                                      
REMARK 465     ALA N   207                                                      
REMARK 465     PRO N   208                                                      
REMARK 465     LEU N   209                                                      
REMARK 465     PRO N   210                                                      
REMARK 465     GLY N   211                                                      
REMARK 465     GLY N   212                                                      
REMARK 465     ILE N   213                                                      
REMARK 465     SER N   214                                                      
REMARK 465     PRO N   215                                                      
REMARK 465     GLN N   216                                                      
REMARK 465     THR N   217                                                      
REMARK 465     GLY N   218                                                      
REMARK 465     VAL N   219                                                      
REMARK 465     ILE N   220                                                      
REMARK 465     ILE N   221                                                      
REMARK 465     GLN N   222                                                      
REMARK 465     PRO N   223                                                      
REMARK 465     GLN N   224                                                      
REMARK 465     GLN N   225                                                      
REMARK 465     ILE N   226                                                      
REMARK 465     LEU N   227                                                      
REMARK 465     PHE N   228                                                      
REMARK 465     THR N   229                                                      
REMARK 465     GLY N   230                                                      
REMARK 465     ASN N   231                                                      
REMARK 465     LYS N   232                                                      
REMARK 465     THR N   233                                                      
REMARK 465     GLN N   234                                                      
REMARK 465     VAL N   235                                                      
REMARK 465     ILE N   236                                                      
REMARK 465     PRO N   237                                                      
REMARK 465     THR N   238                                                      
REMARK 465     THR N   239                                                      
REMARK 465     VAL N   240                                                      
REMARK 465     ALA N   241                                                      
REMARK 465     ALA N   242                                                      
REMARK 465     PRO N   243                                                      
REMARK 465     THR N   244                                                      
REMARK 465     PRO N   245                                                      
REMARK 465     ALA N   246                                                      
REMARK 465     GLN N   247                                                      
REMARK 465     ALA N   248                                                      
REMARK 465     GLN N   249                                                      
REMARK 465     ILE N   250                                                      
REMARK 465     THR N   251                                                      
REMARK 465     ALA N   252                                                      
REMARK 465     THR N   253                                                      
REMARK 465     GLY N   254                                                      
REMARK 465     GLN N   255                                                      
REMARK 465     GLN N   256                                                      
REMARK 465     GLN N   257                                                      
REMARK 465     PRO N   258                                                      
REMARK 465     GLN N   259                                                      
REMARK 465     ALA N   260                                                      
REMARK 465     GLN N   261                                                      
REMARK 465     PRO N   262                                                      
REMARK 465     ALA N   263                                                      
REMARK 465     GLN N   264                                                      
REMARK 465     THR N   265                                                      
REMARK 465     GLN N   266                                                      
REMARK 465     ALA N   267                                                      
REMARK 465     PRO N   268                                                      
REMARK 465     LEU N   269                                                      
REMARK 465     VAL N   270                                                      
REMARK 465     LEU N   271                                                      
REMARK 465     GLN N   272                                                      
REMARK 465     VAL N   273                                                      
REMARK 465     ASP N   274                                                      
REMARK 465     GLY N   275                                                      
REMARK 465     THR N   276                                                      
REMARK 465     GLY N   277                                                      
REMARK 465     ASP N   278                                                      
REMARK 465     THR N   279                                                      
REMARK 465     SER N   280                                                      
REMARK 465     SER N   281                                                      
REMARK 465     GLU N   282                                                      
REMARK 465     GLU N   283                                                      
REMARK 465     ASP N   284                                                      
REMARK 465     GLU N   285                                                      
REMARK 465     ASP N   286                                                      
REMARK 465     GLU N   287                                                      
REMARK 465     GLU N   288                                                      
REMARK 465     GLU N   289                                                      
REMARK 465     ASP N   290                                                      
REMARK 465     TYR N   291                                                      
REMARK 465     ASP N   292                                                      
REMARK 465     ASP N   293                                                      
REMARK 465     ASP N   294                                                      
REMARK 465     GLU N   295                                                      
REMARK 465     GLU N   296                                                      
REMARK 465     GLU N   297                                                      
REMARK 465     ASP N   298                                                      
REMARK 465     LYS N   299                                                      
REMARK 465     GLU N   300                                                      
REMARK 465     LYS N   301                                                      
REMARK 465     ASP N   302                                                      
REMARK 465     GLY N   303                                                      
REMARK 465     ALA N   304                                                      
REMARK 465     GLU N   305                                                      
REMARK 465     ASP N   306                                                      
REMARK 465     GLY O   100                                                      
REMARK 465     LYS O   101                                                      
REMARK 465     ASN O   102                                                      
REMARK 465     THR O   103                                                      
REMARK 465     GLY O   104                                                      
REMARK 465     SER O   105                                                      
REMARK 465     ASN O   106                                                      
REMARK 465     THR O   107                                                      
REMARK 465     THR O   108                                                      
REMARK 465     GLU O   109                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ASP P     2                                                      
REMARK 465     GLN P     3                                                      
REMARK 465     ASN P     4                                                      
REMARK 465     ASN P     5                                                      
REMARK 465     SER P     6                                                      
REMARK 465     LEU P     7                                                      
REMARK 465     PRO P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     TYR P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     GLN P    12                                                      
REMARK 465     GLY P    13                                                      
REMARK 465     LEU P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     SER P    16                                                      
REMARK 465     PRO P    17                                                      
REMARK 465     GLN P    18                                                      
REMARK 465     GLY P    19                                                      
REMARK 465     ALA P    20                                                      
REMARK 465     MET P    21                                                      
REMARK 465     THR P    22                                                      
REMARK 465     PRO P    23                                                      
REMARK 465     GLY P    24                                                      
REMARK 465     ILE P    25                                                      
REMARK 465     PRO P    26                                                      
REMARK 465     ILE P    27                                                      
REMARK 465     PHE P    28                                                      
REMARK 465     SER P    29                                                      
REMARK 465     PRO P    30                                                      
REMARK 465     MET P    31                                                      
REMARK 465     MET P    32                                                      
REMARK 465     PRO P    33                                                      
REMARK 465     TYR P    34                                                      
REMARK 465     GLY P    35                                                      
REMARK 465     THR P    36                                                      
REMARK 465     GLY P    37                                                      
REMARK 465     LEU P    38                                                      
REMARK 465     THR P    39                                                      
REMARK 465     PRO P    40                                                      
REMARK 465     GLN P    41                                                      
REMARK 465     PRO P    42                                                      
REMARK 465     ILE P    43                                                      
REMARK 465     GLN P    44                                                      
REMARK 465     ASN P    45                                                      
REMARK 465     THR P    46                                                      
REMARK 465     ASN P    47                                                      
REMARK 465     SER P    48                                                      
REMARK 465     LEU P    49                                                      
REMARK 465     SER P    50                                                      
REMARK 465     ILE P    51                                                      
REMARK 465     LEU P    52                                                      
REMARK 465     GLU P    53                                                      
REMARK 465     GLU P    54                                                      
REMARK 465     GLN P    55                                                      
REMARK 465     GLN P    56                                                      
REMARK 465     ARG P    57                                                      
REMARK 465     GLN P    58                                                      
REMARK 465     GLN P    59                                                      
REMARK 465     GLN P    60                                                      
REMARK 465     GLN P    61                                                      
REMARK 465     GLN P    62                                                      
REMARK 465     GLN P    63                                                      
REMARK 465     GLN P    64                                                      
REMARK 465     GLN P    65                                                      
REMARK 465     GLN P    66                                                      
REMARK 465     GLN P    67                                                      
REMARK 465     GLN P    68                                                      
REMARK 465     GLN P    69                                                      
REMARK 465     GLN P    70                                                      
REMARK 465     GLN P    71                                                      
REMARK 465     GLN P    72                                                      
REMARK 465     GLN P    73                                                      
REMARK 465     GLN P    74                                                      
REMARK 465     GLN P    75                                                      
REMARK 465     GLN P    76                                                      
REMARK 465     GLN P    77                                                      
REMARK 465     GLN P    78                                                      
REMARK 465     GLN P    79                                                      
REMARK 465     GLN P    80                                                      
REMARK 465     GLN P    81                                                      
REMARK 465     GLN P    82                                                      
REMARK 465     GLN P    83                                                      
REMARK 465     GLN P    84                                                      
REMARK 465     GLN P    85                                                      
REMARK 465     GLN P    86                                                      
REMARK 465     GLN P    87                                                      
REMARK 465     GLN P    88                                                      
REMARK 465     GLN P    89                                                      
REMARK 465     GLN P    90                                                      
REMARK 465     GLN P    91                                                      
REMARK 465     GLN P    92                                                      
REMARK 465     GLN P    93                                                      
REMARK 465     GLN P    94                                                      
REMARK 465     GLN P    95                                                      
REMARK 465     ALA P    96                                                      
REMARK 465     VAL P    97                                                      
REMARK 465     ALA P    98                                                      
REMARK 465     ALA P    99                                                      
REMARK 465     ALA P   100                                                      
REMARK 465     ALA P   101                                                      
REMARK 465     VAL P   102                                                      
REMARK 465     GLN P   103                                                      
REMARK 465     GLN P   104                                                      
REMARK 465     SER P   105                                                      
REMARK 465     THR P   106                                                      
REMARK 465     SER P   107                                                      
REMARK 465     GLN P   108                                                      
REMARK 465     GLN P   109                                                      
REMARK 465     ALA P   110                                                      
REMARK 465     THR P   111                                                      
REMARK 465     GLN P   112                                                      
REMARK 465     GLY P   113                                                      
REMARK 465     THR P   114                                                      
REMARK 465     SER P   115                                                      
REMARK 465     GLY P   116                                                      
REMARK 465     GLN P   117                                                      
REMARK 465     ALA P   118                                                      
REMARK 465     PRO P   119                                                      
REMARK 465     GLN P   120                                                      
REMARK 465     LEU P   121                                                      
REMARK 465     PHE P   122                                                      
REMARK 465     HIS P   123                                                      
REMARK 465     SER P   124                                                      
REMARK 465     GLN P   125                                                      
REMARK 465     THR P   126                                                      
REMARK 465     LEU P   127                                                      
REMARK 465     THR P   128                                                      
REMARK 465     THR P   129                                                      
REMARK 465     ALA P   130                                                      
REMARK 465     PRO P   131                                                      
REMARK 465     LEU P   132                                                      
REMARK 465     PRO P   133                                                      
REMARK 465     GLY P   134                                                      
REMARK 465     THR P   135                                                      
REMARK 465     THR P   136                                                      
REMARK 465     PRO P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     TYR P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     SER P   141                                                      
REMARK 465     PRO P   142                                                      
REMARK 465     MET P   143                                                      
REMARK 465     THR P   144                                                      
REMARK 465     PRO P   145                                                      
REMARK 465     MET P   146                                                      
REMARK 465     THR P   147                                                      
REMARK 465     PRO P   148                                                      
REMARK 465     ILE P   149                                                      
REMARK 465     THR P   150                                                      
REMARK 465     PRO P   151                                                      
REMARK 465     ALA P   152                                                      
REMARK 465     THR P   338                                                      
REMARK 465     THR P   339                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     ALA Q     2                                                      
REMARK 465     ASP Q     3                                                      
REMARK 465     PRO Q     4                                                      
REMARK 465     ASP Q     5                                                      
REMARK 465     VAL Q     6                                                      
REMARK 465     LEU Q     7                                                      
REMARK 465     THR Q     8                                                      
REMARK 465     GLU Q     9                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ASP R     2                                                      
REMARK 465     PRO R     3                                                      
REMARK 465     SER R     4                                                      
REMARK 465     LEU R     5                                                      
REMARK 465     LEU R     6                                                      
REMARK 465     ARG R     7                                                      
REMARK 465     GLU R     8                                                      
REMARK 465     ARG R     9                                                      
REMARK 465     GLU R    10                                                      
REMARK 465     LEU R    11                                                      
REMARK 465     PHE R    12                                                      
REMARK 465     LYS R    13                                                      
REMARK 465     LYS R    14                                                      
REMARK 465     ARG R    15                                                      
REMARK 465     ALA R    16                                                      
REMARK 465     LEU R    17                                                      
REMARK 465     SER R    18                                                      
REMARK 465     THR R    19                                                      
REMARK 465     PRO R    20                                                      
REMARK 465     VAL R    21                                                      
REMARK 465     VAL R    22                                                      
REMARK 465     GLU R    23                                                      
REMARK 465     LYS R    24                                                      
REMARK 465     ARG R    25                                                      
REMARK 465     SER R    26                                                      
REMARK 465     ALA R    27                                                      
REMARK 465     SER R    28                                                      
REMARK 465     SER R    29                                                      
REMARK 465     GLU R    30                                                      
REMARK 465     SER R    31                                                      
REMARK 465     SER R    32                                                      
REMARK 465     SER R    33                                                      
REMARK 465     SER R    34                                                      
REMARK 465     SER R    35                                                      
REMARK 465     SER R    36                                                      
REMARK 465     LYS R    37                                                      
REMARK 465     LYS R    38                                                      
REMARK 465     LYS R    39                                                      
REMARK 465     LYS R    40                                                      
REMARK 465     THR R    41                                                      
REMARK 465     LYS R    42                                                      
REMARK 465     VAL R    43                                                      
REMARK 465     GLU R    44                                                      
REMARK 465     HIS R    45                                                      
REMARK 465     GLY R    46                                                      
REMARK 465     GLY R    47                                                      
REMARK 465     SER R    48                                                      
REMARK 465     SER R    49                                                      
REMARK 465     GLY R    50                                                      
REMARK 465     SER R    51                                                      
REMARK 465     LYS R    52                                                      
REMARK 465     GLN R    53                                                      
REMARK 465     ASN R    54                                                      
REMARK 465     SER R    55                                                      
REMARK 465     ASP R    56                                                      
REMARK 465     HIS R    57                                                      
REMARK 465     SER R    58                                                      
REMARK 465     ASN R    59                                                      
REMARK 465     GLY R    60                                                      
REMARK 465     SER R    61                                                      
REMARK 465     PHE R    62                                                      
REMARK 465     ASN R    63                                                      
REMARK 465     LEU R    64                                                      
REMARK 465     LYS R    65                                                      
REMARK 465     ALA R    66                                                      
REMARK 465     LEU R    67                                                      
REMARK 465     SER R    68                                                      
REMARK 465     GLY R    69                                                      
REMARK 465     SER R    70                                                      
REMARK 465     SER R    71                                                      
REMARK 465     GLY R    72                                                      
REMARK 465     TYR R    73                                                      
REMARK 465     LYS R    74                                                      
REMARK 465     SER R   243                                                      
REMARK 465     SER R   244                                                      
REMARK 465     MET R   245                                                      
REMARK 465     GLN R   246                                                      
REMARK 465     GLU R   247                                                      
REMARK 465     SER R   248                                                      
REMARK 465     GLY R   249                                                      
REMARK 465     PRO R   250                                                      
REMARK 465     LYS R   251                                                      
REMARK 465     LYS R   252                                                      
REMARK 465     VAL R   253                                                      
REMARK 465     ALA R   254                                                      
REMARK 465     PRO R   255                                                      
REMARK 465     ILE R   256                                                      
REMARK 465     GLN R   257                                                      
REMARK 465     ARG R   258                                                      
REMARK 465     ARG R   259                                                      
REMARK 465     LYS R   260                                                      
REMARK 465     LYS R   261                                                      
REMARK 465     PRO R   262                                                      
REMARK 465     ALA R   263                                                      
REMARK 465     SER R   264                                                      
REMARK 465     GLN R   265                                                      
REMARK 465     LYS R   266                                                      
REMARK 465     LYS R   267                                                      
REMARK 465     ARG R   268                                                      
REMARK 465     ARG R   269                                                      
REMARK 465     PHE R   270                                                      
REMARK 465     LYS R   271                                                      
REMARK 465     THR R   272                                                      
REMARK 465     HIS R   273                                                      
REMARK 465     ASN R   274                                                      
REMARK 465     GLU R   275                                                      
REMARK 465     HIS R   276                                                      
REMARK 465     LEU R   277                                                      
REMARK 465     ALA R   278                                                      
REMARK 465     GLY R   279                                                      
REMARK 465     VAL R   280                                                      
REMARK 465     LEU R   281                                                      
REMARK 465     LYS R   282                                                      
REMARK 465     ASP R   283                                                      
REMARK 465     TYR R   284                                                      
REMARK 465     SER R   285                                                      
REMARK 465     ASP R   286                                                      
REMARK 465     ILE R   287                                                      
REMARK 465     THR R   288                                                      
REMARK 465     SER R   289                                                      
REMARK 465     SER R   290                                                      
REMARK 465     LYS R   291                                                      
REMARK 465     MET S     1                                                      
REMARK 465     ALA S     2                                                      
REMARK 465     ALA S     3                                                      
REMARK 465     LEU S     4                                                      
REMARK 465     ARG S   181                                                      
REMARK 465     LEU S   182                                                      
REMARK 465     LYS S   183                                                      
REMARK 465     ASP S   184                                                      
REMARK 465     GLN S   185                                                      
REMARK 465     ASP S   186                                                      
REMARK 465     GLN S   187                                                      
REMARK 465     ASP S   188                                                      
REMARK 465     GLU S   189                                                      
REMARK 465     ASP S   190                                                      
REMARK 465     GLU S   191                                                      
REMARK 465     GLU S   192                                                      
REMARK 465     GLU S   193                                                      
REMARK 465     LYS S   194                                                      
REMARK 465     GLU S   195                                                      
REMARK 465     LYS S   196                                                      
REMARK 465     ARG S   197                                                      
REMARK 465     GLY S   198                                                      
REMARK 465     ARG S   199                                                      
REMARK 465     ARG S   200                                                      
REMARK 465     LYS S   201                                                      
REMARK 465     ALA S   202                                                      
REMARK 465     SER S   203                                                      
REMARK 465     GLU S   204                                                      
REMARK 465     LEU S   205                                                      
REMARK 465     ARG S   206                                                      
REMARK 465     ILE S   207                                                      
REMARK 465     HIS S   208                                                      
REMARK 465     ASP S   209                                                      
REMARK 465     LEU S   210                                                      
REMARK 465     GLU S   211                                                      
REMARK 465     ASP S   212                                                      
REMARK 465     ASP S   213                                                      
REMARK 465     LEU S   214                                                      
REMARK 465     GLU S   215                                                      
REMARK 465     MET S   216                                                      
REMARK 465     SER S   217                                                      
REMARK 465     SER S   218                                                      
REMARK 465     ASP S   219                                                      
REMARK 465     ALA S   220                                                      
REMARK 465     SER S   221                                                      
REMARK 465     ASP S   222                                                      
REMARK 465     ALA S   223                                                      
REMARK 465     SER S   224                                                      
REMARK 465     GLY S   225                                                      
REMARK 465     GLU S   226                                                      
REMARK 465     GLU S   227                                                      
REMARK 465     GLY S   228                                                      
REMARK 465     GLY S   229                                                      
REMARK 465     ARG S   230                                                      
REMARK 465     VAL S   231                                                      
REMARK 465     PRO S   232                                                      
REMARK 465     LYS S   233                                                      
REMARK 465     ALA S   234                                                      
REMARK 465     LYS S   235                                                      
REMARK 465     LYS S   236                                                      
REMARK 465     LYS S   237                                                      
REMARK 465     ALA S   238                                                      
REMARK 465     PRO S   239                                                      
REMARK 465     LEU S   240                                                      
REMARK 465     ALA S   241                                                      
REMARK 465     LYS S   242                                                      
REMARK 465     GLY S   243                                                      
REMARK 465     GLY S   244                                                      
REMARK 465     ARG S   245                                                      
REMARK 465     LYS S   246                                                      
REMARK 465     LYS S   247                                                      
REMARK 465     LYS S   248                                                      
REMARK 465     LYS S   249                                                      
REMARK 465     LYS S   250                                                      
REMARK 465     LYS S   251                                                      
REMARK 465     GLY S   252                                                      
REMARK 465     SER S   253                                                      
REMARK 465     ASP S   254                                                      
REMARK 465     ASP S   255                                                      
REMARK 465     GLU S   256                                                      
REMARK 465     ALA S   257                                                      
REMARK 465     PHE S   258                                                      
REMARK 465     GLU S   259                                                      
REMARK 465     ASP S   260                                                      
REMARK 465     SER S   261                                                      
REMARK 465     ASP S   262                                                      
REMARK 465     ASP S   263                                                      
REMARK 465     GLY S   264                                                      
REMARK 465     ASP S   265                                                      
REMARK 465     PHE S   266                                                      
REMARK 465     GLU S   267                                                      
REMARK 465     GLY S   268                                                      
REMARK 465     GLN S   269                                                      
REMARK 465     GLU S   270                                                      
REMARK 465     VAL S   271                                                      
REMARK 465     ASP S   272                                                      
REMARK 465     TYR S   273                                                      
REMARK 465     MET S   274                                                      
REMARK 465     SER S   275                                                      
REMARK 465     ASP S   276                                                      
REMARK 465     GLY S   277                                                      
REMARK 465     SER S   278                                                      
REMARK 465     SER S   279                                                      
REMARK 465     SER S   280                                                      
REMARK 465     SER S   281                                                      
REMARK 465     GLN S   282                                                      
REMARK 465     GLU S   283                                                      
REMARK 465     GLU S   284                                                      
REMARK 465     PRO S   285                                                      
REMARK 465     GLU S   286                                                      
REMARK 465     SER S   287                                                      
REMARK 465     LYS S   288                                                      
REMARK 465     ALA S   289                                                      
REMARK 465     LYS S   290                                                      
REMARK 465     ALA S   291                                                      
REMARK 465     PRO S   292                                                      
REMARK 465     GLN S   293                                                      
REMARK 465     GLN S   294                                                      
REMARK 465     GLU S   295                                                      
REMARK 465     GLU S   296                                                      
REMARK 465     GLY S   297                                                      
REMARK 465     PRO S   298                                                      
REMARK 465     LYS S   299                                                      
REMARK 465     GLY S   300                                                      
REMARK 465     VAL S   301                                                      
REMARK 465     ASP S   302                                                      
REMARK 465     GLU S   303                                                      
REMARK 465     GLN S   304                                                      
REMARK 465     SER S   305                                                      
REMARK 465     ASP S   306                                                      
REMARK 465     SER S   307                                                      
REMARK 465     SER S   308                                                      
REMARK 465     GLU S   309                                                      
REMARK 465     GLU S   310                                                      
REMARK 465     SER S   311                                                      
REMARK 465     GLU S   312                                                      
REMARK 465     GLU S   313                                                      
REMARK 465     GLU S   314                                                      
REMARK 465     LYS S   315                                                      
REMARK 465     PRO S   316                                                      
REMARK 465     PRO S   317                                                      
REMARK 465     GLU S   318                                                      
REMARK 465     GLU S   319                                                      
REMARK 465     ASP S   320                                                      
REMARK 465     LYS S   321                                                      
REMARK 465     GLU S   322                                                      
REMARK 465     GLU S   323                                                      
REMARK 465     GLU S   324                                                      
REMARK 465     GLU S   325                                                      
REMARK 465     GLU S   326                                                      
REMARK 465     LYS S   327                                                      
REMARK 465     LYS S   328                                                      
REMARK 465     ALA S   329                                                      
REMARK 465     PRO S   330                                                      
REMARK 465     THR S   331                                                      
REMARK 465     PRO S   332                                                      
REMARK 465     GLN S   333                                                      
REMARK 465     GLU S   334                                                      
REMARK 465     LYS S   335                                                      
REMARK 465     LYS S   336                                                      
REMARK 465     ARG S   337                                                      
REMARK 465     ARG S   338                                                      
REMARK 465     LYS S   339                                                      
REMARK 465     ASP S   340                                                      
REMARK 465     SER S   341                                                      
REMARK 465     SER S   342                                                      
REMARK 465     GLU S   343                                                      
REMARK 465     GLU S   344                                                      
REMARK 465     SER S   345                                                      
REMARK 465     ASP S   346                                                      
REMARK 465     SER S   347                                                      
REMARK 465     SER S   348                                                      
REMARK 465     GLU S   349                                                      
REMARK 465     GLU S   350                                                      
REMARK 465     SER S   351                                                      
REMARK 465     ASP S   352                                                      
REMARK 465     ILE S   353                                                      
REMARK 465     ASP S   354                                                      
REMARK 465     SER S   355                                                      
REMARK 465     GLU S   356                                                      
REMARK 465     ALA S   357                                                      
REMARK 465     SER S   358                                                      
REMARK 465     SER S   359                                                      
REMARK 465     ALA S   360                                                      
REMARK 465     LEU S   361                                                      
REMARK 465     PHE S   362                                                      
REMARK 465     MET S   363                                                      
REMARK 465     ALA S   364                                                      
REMARK 465     LYS S   365                                                      
REMARK 465     LYS S   366                                                      
REMARK 465     LYS S   367                                                      
REMARK 465     THR S   368                                                      
REMARK 465     PRO S   369                                                      
REMARK 465     PRO S   370                                                      
REMARK 465     LYS S   371                                                      
REMARK 465     ARG S   372                                                      
REMARK 465     GLU S   373                                                      
REMARK 465     ARG S   374                                                      
REMARK 465     LYS S   375                                                      
REMARK 465     PRO S   376                                                      
REMARK 465     SER S   377                                                      
REMARK 465     GLY S   378                                                      
REMARK 465     GLY S   379                                                      
REMARK 465     SER S   380                                                      
REMARK 465     SER S   381                                                      
REMARK 465     ARG S   382                                                      
REMARK 465     GLY S   383                                                      
REMARK 465     ASN S   384                                                      
REMARK 465     SER S   385                                                      
REMARK 465     ARG S   386                                                      
REMARK 465     PRO S   387                                                      
REMARK 465     GLY S   388                                                      
REMARK 465     THR S   389                                                      
REMARK 465     PRO S   390                                                      
REMARK 465     SER S   391                                                      
REMARK 465     ALA S   392                                                      
REMARK 465     GLU S   393                                                      
REMARK 465     GLY S   394                                                      
REMARK 465     GLY S   395                                                      
REMARK 465     SER S   396                                                      
REMARK 465     THR S   397                                                      
REMARK 465     SER S   398                                                      
REMARK 465     SER S   399                                                      
REMARK 465     THR S   400                                                      
REMARK 465     LEU S   401                                                      
REMARK 465     ARG S   402                                                      
REMARK 465     ALA S   403                                                      
REMARK 465     ALA S   404                                                      
REMARK 465     ALA S   405                                                      
REMARK 465     SER S   406                                                      
REMARK 465     LYS S   407                                                      
REMARK 465     LEU S   408                                                      
REMARK 465     GLU S   409                                                      
REMARK 465     GLN S   410                                                      
REMARK 465     GLY S   411                                                      
REMARK 465     LYS S   412                                                      
REMARK 465     ARG S   413                                                      
REMARK 465     VAL S   414                                                      
REMARK 465     SER S   415                                                      
REMARK 465     GLU S   416                                                      
REMARK 465     MET S   417                                                      
REMARK 465     PRO S   418                                                      
REMARK 465     ALA S   419                                                      
REMARK 465     ALA S   420                                                      
REMARK 465     LYS S   421                                                      
REMARK 465     ARG S   422                                                      
REMARK 465     LEU S   423                                                      
REMARK 465     ARG S   424                                                      
REMARK 465     LEU S   425                                                      
REMARK 465     ASP S   426                                                      
REMARK 465     THR S   427                                                      
REMARK 465     GLY S   428                                                      
REMARK 465     PRO S   429                                                      
REMARK 465     GLN S   430                                                      
REMARK 465     SER S   431                                                      
REMARK 465     LEU S   432                                                      
REMARK 465     SER S   433                                                      
REMARK 465     GLY S   434                                                      
REMARK 465     LYS S   435                                                      
REMARK 465     SER S   436                                                      
REMARK 465     THR S   437                                                      
REMARK 465     PRO S   438                                                      
REMARK 465     GLN S   439                                                      
REMARK 465     PRO S   440                                                      
REMARK 465     PRO S   441                                                      
REMARK 465     SER S   442                                                      
REMARK 465     GLY S   443                                                      
REMARK 465     LYS S   444                                                      
REMARK 465     THR S   445                                                      
REMARK 465     THR S   446                                                      
REMARK 465     PRO S   447                                                      
REMARK 465     ASN S   448                                                      
REMARK 465     SER S   449                                                      
REMARK 465     GLY S   450                                                      
REMARK 465     ASP S   451                                                      
REMARK 465     VAL S   452                                                      
REMARK 465     GLN S   453                                                      
REMARK 465     VAL S   454                                                      
REMARK 465     THR S   455                                                      
REMARK 465     GLU S   456                                                      
REMARK 465     ASP S   457                                                      
REMARK 465     ALA S   458                                                      
REMARK 465     VAL S   459                                                      
REMARK 465     ARG S   460                                                      
REMARK 465     ARG S   461                                                      
REMARK 465     TYR S   462                                                      
REMARK 465     LEU S   463                                                      
REMARK 465     THR S   464                                                      
REMARK 465     ARG S   465                                                      
REMARK 465     LYS S   466                                                      
REMARK 465     PRO S   467                                                      
REMARK 465     MET S   468                                                      
REMARK 465     THR S   469                                                      
REMARK 465     THR S   470                                                      
REMARK 465     LYS S   471                                                      
REMARK 465     ASP S   472                                                      
REMARK 465     LEU S   473                                                      
REMARK 465     LEU S   474                                                      
REMARK 465     LYS S   475                                                      
REMARK 465     LYS S   476                                                      
REMARK 465     PHE S   477                                                      
REMARK 465     GLN S   478                                                      
REMARK 465     THR S   479                                                      
REMARK 465     LYS S   480                                                      
REMARK 465     LYS S   481                                                      
REMARK 465     THR S   482                                                      
REMARK 465     GLY S   483                                                      
REMARK 465     LEU S   484                                                      
REMARK 465     SER S   485                                                      
REMARK 465     SER S   486                                                      
REMARK 465     GLU S   487                                                      
REMARK 465     GLN S   488                                                      
REMARK 465     THR S   489                                                      
REMARK 465     VAL S   490                                                      
REMARK 465     ASN S   491                                                      
REMARK 465     VAL S   492                                                      
REMARK 465     LEU S   493                                                      
REMARK 465     ALA S   494                                                      
REMARK 465     GLN S   495                                                      
REMARK 465     ILE S   496                                                      
REMARK 465     LEU S   497                                                      
REMARK 465     LYS S   498                                                      
REMARK 465     ARG S   499                                                      
REMARK 465     LEU S   500                                                      
REMARK 465     ASN S   501                                                      
REMARK 465     PRO S   502                                                      
REMARK 465     GLU S   503                                                      
REMARK 465     ARG S   504                                                      
REMARK 465     LYS S   505                                                      
REMARK 465     MET S   506                                                      
REMARK 465     ILE S   507                                                      
REMARK 465     ASN S   508                                                      
REMARK 465     ASP S   509                                                      
REMARK 465     LYS S   510                                                      
REMARK 465     MET S   511                                                      
REMARK 465     HIS S   512                                                      
REMARK 465     PHE S   513                                                      
REMARK 465     SER S   514                                                      
REMARK 465     LEU S   515                                                      
REMARK 465     LYS S   516                                                      
REMARK 465     GLU S   517                                                      
REMARK 465     MET T     1                                                      
REMARK 465     TYR T   239                                                      
REMARK 465     ARG T   240                                                      
REMARK 465     HIS T   241                                                      
REMARK 465     TYR T   242                                                      
REMARK 465     GLN T   243                                                      
REMARK 465     GLY T   244                                                      
REMARK 465     GLU T   245                                                      
REMARK 465     GLU T   246                                                      
REMARK 465     LYS T   247                                                      
REMARK 465     SER T   248                                                      
REMARK 465     ASP T   249                                                      
REMARK 465     MET U     1                                                      
REMARK 465     GLU U     2                                                      
REMARK 465     ASP U     3                                                      
REMARK 465     GLU U     4                                                      
REMARK 465     VAL U     5                                                      
REMARK 465     VAL U     6                                                      
REMARK 465     ARG U     7                                                      
REMARK 465     PHE U     8                                                      
REMARK 465     ALA U     9                                                      
REMARK 465     LYS U    10                                                      
REMARK 465     LYS U    11                                                      
REMARK 465     MET U    12                                                      
REMARK 465     ASP U    13                                                      
REMARK 465     LYS U    14                                                      
REMARK 465     MET U    15                                                      
REMARK 465     VAL U    16                                                      
REMARK 465     GLN U    17                                                      
REMARK 465     LYS U    18                                                      
REMARK 465     LYS U    19                                                      
REMARK 465     ASN U    20                                                      
REMARK 465     ALA U    21                                                      
REMARK 465     ALA U    22                                                      
REMARK 465     GLY U    23                                                      
REMARK 465     ALA U    24                                                      
REMARK 465     LEU U    25                                                      
REMARK 465     ASP U    26                                                      
REMARK 465     LEU U    27                                                      
REMARK 465     LEU U    28                                                      
REMARK 465     LYS U    29                                                      
REMARK 465     GLU U    30                                                      
REMARK 465     LEU U    31                                                      
REMARK 465     LYS U    32                                                      
REMARK 465     ASN U    33                                                      
REMARK 465     ILE U    34                                                      
REMARK 465     PRO U    35                                                      
REMARK 465     MET U    36                                                      
REMARK 465     THR U    37                                                      
REMARK 465     LEU U    38                                                      
REMARK 465     GLU U    39                                                      
REMARK 465     LEU U    40                                                      
REMARK 465     LEU U    41                                                      
REMARK 465     GLN U    42                                                      
REMARK 465     SER U    43                                                      
REMARK 465     THR U    44                                                      
REMARK 465     ARG U    45                                                      
REMARK 465     ILE U    46                                                      
REMARK 465     GLY U    47                                                      
REMARK 465     MET U    48                                                      
REMARK 465     SER U    49                                                      
REMARK 465     VAL U    50                                                      
REMARK 465     ASN U    51                                                      
REMARK 465     ALA U    52                                                      
REMARK 465     ILE U    53                                                      
REMARK 465     ARG U    54                                                      
REMARK 465     LYS U    55                                                      
REMARK 465     GLN U    56                                                      
REMARK 465     SER U    57                                                      
REMARK 465     THR U    58                                                      
REMARK 465     ASP U    59                                                      
REMARK 465     GLU U    60                                                      
REMARK 465     GLU U    61                                                      
REMARK 465     VAL U    62                                                      
REMARK 465     THR U    63                                                      
REMARK 465     SER U    64                                                      
REMARK 465     LEU U    65                                                      
REMARK 465     ALA U    66                                                      
REMARK 465     LYS U    67                                                      
REMARK 465     SER U    68                                                      
REMARK 465     LEU U    69                                                      
REMARK 465     ILE U    70                                                      
REMARK 465     LYS U    71                                                      
REMARK 465     SER U    72                                                      
REMARK 465     TRP U    73                                                      
REMARK 465     LYS U    74                                                      
REMARK 465     LYS U    75                                                      
REMARK 465     LEU U    76                                                      
REMARK 465     LEU U    77                                                      
REMARK 465     ASP U    78                                                      
REMARK 465     GLY U    79                                                      
REMARK 465     PRO U    80                                                      
REMARK 465     SER U    81                                                      
REMARK 465     THR U    82                                                      
REMARK 465     GLU U    83                                                      
REMARK 465     LYS U    84                                                      
REMARK 465     ASP U    85                                                      
REMARK 465     LEU U    86                                                      
REMARK 465     ASP U    87                                                      
REMARK 465     GLU U    88                                                      
REMARK 465     LYS U    89                                                      
REMARK 465     LYS U    90                                                      
REMARK 465     LYS U    91                                                      
REMARK 465     GLU U    92                                                      
REMARK 465     PRO U    93                                                      
REMARK 465     ALA U    94                                                      
REMARK 465     ILE U    95                                                      
REMARK 465     THR U    96                                                      
REMARK 465     SER U    97                                                      
REMARK 465     GLN U    98                                                      
REMARK 465     ASN U    99                                                      
REMARK 465     SER U   100                                                      
REMARK 465     PRO U   101                                                      
REMARK 465     GLU U   102                                                      
REMARK 465     ALA U   103                                                      
REMARK 465     ARG U   104                                                      
REMARK 465     GLU U   105                                                      
REMARK 465     GLU U   106                                                      
REMARK 465     SER U   107                                                      
REMARK 465     THR U   108                                                      
REMARK 465     SER U   109                                                      
REMARK 465     SER U   110                                                      
REMARK 465     GLY U   111                                                      
REMARK 465     ASN U   112                                                      
REMARK 465     VAL U   113                                                      
REMARK 465     SER U   114                                                      
REMARK 465     ASN U   115                                                      
REMARK 465     ARG U   116                                                      
REMARK 465     LYS U   117                                                      
REMARK 465     ASP U   118                                                      
REMARK 465     GLU U   119                                                      
REMARK 465     THR U   120                                                      
REMARK 465     ASN U   121                                                      
REMARK 465     ALA U   122                                                      
REMARK 465     ARG U   123                                                      
REMARK 465     ASP U   124                                                      
REMARK 465     THR U   125                                                      
REMARK 465     TYR U   126                                                      
REMARK 465     VAL U   127                                                      
REMARK 465     SER U   128                                                      
REMARK 465     SER U   129                                                      
REMARK 465     PHE U   130                                                      
REMARK 465     PRO U   131                                                      
REMARK 465     MET 0     1                                                      
REMARK 465     LYS 0     2                                                      
REMARK 465     LEU 0     3                                                      
REMARK 465     ASN 0     4                                                      
REMARK 465     VAL 0     5                                                      
REMARK 465     ASP 0     6                                                      
REMARK 465     GLY 0     7                                                      
REMARK 465     LEU 0     8                                                      
REMARK 465     LEU 0     9                                                      
REMARK 465     VAL 0    10                                                      
REMARK 465     GLN 0   743                                                      
REMARK 465     LEU 0   744                                                      
REMARK 465     GLU 0   745                                                      
REMARK 465     SER 0   746                                                      
REMARK 465     GLU 0   747                                                      
REMARK 465     GLU 0   748                                                      
REMARK 465     THR 0   749                                                      
REMARK 465     LEU 0   750                                                      
REMARK 465     LYS 0   751                                                      
REMARK 465     ARG 0   752                                                      
REMARK 465     ILE 0   753                                                      
REMARK 465     GLU 0   754                                                      
REMARK 465     GLN 0   755                                                      
REMARK 465     ILE 0   756                                                      
REMARK 465     ALA 0   757                                                      
REMARK 465     GLN 0   758                                                      
REMARK 465     GLN 0   759                                                      
REMARK 465     LEU 0   760                                                      
REMARK 465     LYS 1   547                                                      
REMARK 465     THR 1   548                                                      
REMARK 465     MET 2     1                                                      
REMARK 465     GLU 2     2                                                      
REMARK 465     SER 2     3                                                      
REMARK 465     THR 2     4                                                      
REMARK 465     PRO 2     5                                                      
REMARK 465     LYS 2   459                                                      
REMARK 465     HIS 2   460                                                      
REMARK 465     SER 2   461                                                      
REMARK 465     SER 2   462                                                      
REMARK 465     MET 4     1                                                      
REMARK 465     VAL 4     2                                                      
REMARK 465     SER 4     3                                                      
REMARK 465     ASP 4     4                                                      
REMARK 465     GLU 4     5                                                      
REMARK 465     LYS 4   301                                                      
REMARK 465     LYS 4   302                                                      
REMARK 465     LYS 4   303                                                      
REMARK 465     LEU 4   304                                                      
REMARK 465     LYS 4   305                                                      
REMARK 465     VAL 4   306                                                      
REMARK 465     SER 4   307                                                      
REMARK 465     ALA 4   308                                                      
REMARK 465     MET 5     1                                                      
REMARK 465     LEU 5    68                                                      
REMARK 465     THR 5    69                                                      
REMARK 465     GLN 5    70                                                      
REMARK 465     LYS 5    71                                                      
REMARK 465     MET 6     1                                                      
REMARK 465     ASP 6     2                                                      
REMARK 465     GLU 6     3                                                      
REMARK 465     GLU 6     4                                                      
REMARK 465     PRO 6     5                                                      
REMARK 465     GLU 6     6                                                      
REMARK 465     ARG 6     7                                                      
REMARK 465     THR 6     8                                                      
REMARK 465     LYS 6     9                                                      
REMARK 465     VAL 6   395                                                      
REMARK 465     MET 7     1                                                      
REMARK 465     GLY 7     2                                                      
REMARK 465     LYS 7     3                                                      
REMARK 465     ARG 7     4                                                      
REMARK 465     ASP 7     5                                                      
REMARK 465     ARG 7     6                                                      
REMARK 465     ALA 7     7                                                      
REMARK 465     ASP 7     8                                                      
REMARK 465     ARG 7     9                                                      
REMARK 465     ASP 7    10                                                      
REMARK 465     LYS 7    11                                                      
REMARK 465     LYS 7    12                                                      
REMARK 465     LYS 7    13                                                      
REMARK 465     SER 7    14                                                      
REMARK 465     ARG 7    15                                                      
REMARK 465     LYS 7    16                                                      
REMARK 465     ARG 7    17                                                      
REMARK 465     HIS 7    18                                                      
REMARK 465     TYR 7    19                                                      
REMARK 465     GLU 7    20                                                      
REMARK 465     ASP 7    21                                                      
REMARK 465     GLU 7    22                                                      
REMARK 465     GLU 7    23                                                      
REMARK 465     ASP 7    24                                                      
REMARK 465     ASP 7    25                                                      
REMARK 465     GLU 7    26                                                      
REMARK 465     GLU 7    27                                                      
REMARK 465     ASP 7    28                                                      
REMARK 465     ALA 7    29                                                      
REMARK 465     SER 7   202                                                      
REMARK 465     GLU 7   203                                                      
REMARK 465     GLY 7   204                                                      
REMARK 465     GLU 7   205                                                      
REMARK 465     ALA 7   206                                                      
REMARK 465     THR 7   207                                                      
REMARK 465     GLU 7   208                                                      
REMARK 465     LEU 7   209                                                      
REMARK 465     ILE 7   210                                                      
REMARK 465     THR 7   211                                                      
REMARK 465     GLU 7   212                                                      
REMARK 465     THR 7   213                                                      
REMARK 465     PHE 7   214                                                      
REMARK 465     THR 7   215                                                      
REMARK 465     SER 7   216                                                      
REMARK 465     LYS 7   217                                                      
REMARK 465     SER 7   218                                                      
REMARK 465     ALA 7   219                                                      
REMARK 465     ILE 7   220                                                      
REMARK 465     SER 7   221                                                      
REMARK 465     LYS 7   222                                                      
REMARK 465     THR 7   223                                                      
REMARK 465     ALA 7   224                                                      
REMARK 465     GLU 7   225                                                      
REMARK 465     SER 7   226                                                      
REMARK 465     SER 7   227                                                      
REMARK 465     GLY 7   228                                                      
REMARK 465     GLY 7   229                                                      
REMARK 465     PRO 7   230                                                      
REMARK 465     SER 7   231                                                      
REMARK 465     THR 7   232                                                      
REMARK 465     SER 7   233                                                      
REMARK 465     ARG 7   234                                                      
REMARK 465     VAL 7   235                                                      
REMARK 465     THR 7   236                                                      
REMARK 465     ASP 7   237                                                      
REMARK 465     PRO 7   238                                                      
REMARK 465     GLN 7   239                                                      
REMARK 465     GLY 7   240                                                      
REMARK 465     LYS 7   241                                                      
REMARK 465     SER 7   242                                                      
REMARK 465     ASP 7   243                                                      
REMARK 465     ILE 7   244                                                      
REMARK 465     PRO 7   245                                                      
REMARK 465     MET 7   246                                                      
REMARK 465     ASP 7   247                                                      
REMARK 465     LEU 7   248                                                      
REMARK 465     PHE 7   249                                                      
REMARK 465     ASP 7   250                                                      
REMARK 465     PHE 7   251                                                      
REMARK 465     TYR 7   252                                                      
REMARK 465     GLU 7   253                                                      
REMARK 465     GLN 7   254                                                      
REMARK 465     MET 7   255                                                      
REMARK 465     ASP 7   256                                                      
REMARK 465     LYS 7   257                                                      
REMARK 465     ASP 7   258                                                      
REMARK 465     GLU 7   259                                                      
REMARK 465     GLU 7   260                                                      
REMARK 465     GLU 7   261                                                      
REMARK 465     GLU 7   262                                                      
REMARK 465     GLU 7   263                                                      
REMARK 465     GLU 7   264                                                      
REMARK 465     THR 7   265                                                      
REMARK 465     GLN 7   266                                                      
REMARK 465     VAL 7   729                                                      
REMARK 465     ALA 7   730                                                      
REMARK 465     GLY 7   731                                                      
REMARK 465     GLU 7   732                                                      
REMARK 465     PHE 7   733                                                      
REMARK 465     GLY 7   734                                                      
REMARK 465     SER 7   735                                                      
REMARK 465     ARG 7   736                                                      
REMARK 465     SER 7   737                                                      
REMARK 465     SER 7   738                                                      
REMARK 465     GLN 7   739                                                      
REMARK 465     ALA 7   740                                                      
REMARK 465     SER 7   741                                                      
REMARK 465     ARG 7   742                                                      
REMARK 465     ARG 7   743                                                      
REMARK 465     PHE 7   744                                                      
REMARK 465     GLY 7   745                                                      
REMARK 465     THR 7   746                                                      
REMARK 465     MET 7   747                                                      
REMARK 465     SER 7   748                                                      
REMARK 465     SER 7   749                                                      
REMARK 465     MET 7   750                                                      
REMARK 465     SER 7   751                                                      
REMARK 465     GLY 7   752                                                      
REMARK 465     ALA 7   753                                                      
REMARK 465     ASP 7   754                                                      
REMARK 465     ASP 7   755                                                      
REMARK 465     THR 7   756                                                      
REMARK 465     VAL 7   757                                                      
REMARK 465     TYR 7   758                                                      
REMARK 465     MET 7   759                                                      
REMARK 465     GLU 7   760                                                      
REMARK 465     TYR 7   761                                                      
REMARK 465     HIS 7   762                                                      
REMARK 465     SER 7   763                                                      
REMARK 465     SER 7   764                                                      
REMARK 465     ARG 7   765                                                      
REMARK 465     SER 7   766                                                      
REMARK 465     LYS 7   767                                                      
REMARK 465     ALA 7   768                                                      
REMARK 465     PRO 7   769                                                      
REMARK 465     SER 7   770                                                      
REMARK 465     LYS 7   771                                                      
REMARK 465     HIS 7   772                                                      
REMARK 465     VAL 7   773                                                      
REMARK 465     HIS 7   774                                                      
REMARK 465     PRO 7   775                                                      
REMARK 465     LEU 7   776                                                      
REMARK 465     PHE 7   777                                                      
REMARK 465     LYS 7   778                                                      
REMARK 465     ARG 7   779                                                      
REMARK 465     PHE 7   780                                                      
REMARK 465     ARG 7   781                                                      
REMARK 465     LYS 7   782                                                      
REMARK 465     MET 8     1                                                      
REMARK 465     ALA 8     2                                                      
REMARK 465     LEU 8     3                                                      
REMARK 465     ASP 8     4                                                      
REMARK 465     VAL 8     5                                                      
REMARK 465     LYS 8     6                                                      
REMARK 465     SER 8     7                                                      
REMARK 465     ARG 8     8                                                      
REMARK 465     ALA 8     9                                                      
REMARK 465     LYS 8    10                                                      
REMARK 465     ARG 8    11                                                      
REMARK 465     TYR 8    12                                                      
REMARK 465     CYS 8   312                                                      
REMARK 465     PRO 8   313                                                      
REMARK 465     VAL 8   314                                                      
REMARK 465     GLU 8   315                                                      
REMARK 465     THR 8   316                                                      
REMARK 465     LEU 8   317                                                      
REMARK 465     LYS 8   318                                                      
REMARK 465     GLU 8   319                                                      
REMARK 465     GLN 8   320                                                      
REMARK 465     SER 8   321                                                      
REMARK 465     ASN 8   322                                                      
REMARK 465     PRO 8   323                                                      
REMARK 465     ALA 8   324                                                      
REMARK 465     LEU 8   325                                                      
REMARK 465     ALA 8   326                                                      
REMARK 465     ILE 8   327                                                      
REMARK 465     LYS 8   328                                                      
REMARK 465     ARG 8   329                                                      
REMARK 465     LYS 8   330                                                      
REMARK 465     ARG 8   331                                                      
REMARK 465     THR 8   332                                                      
REMARK 465     GLU 8   333                                                      
REMARK 465     ALA 8   334                                                      
REMARK 465     LEU 8   335                                                      
REMARK 465     GLU 8   336                                                      
REMARK 465     GLN 8   337                                                      
REMARK 465     GLY 8   338                                                      
REMARK 465     GLY 8   339                                                      
REMARK 465     LEU 8   340                                                      
REMARK 465     PRO 8   341                                                      
REMARK 465     LYS 8   342                                                      
REMARK 465     LYS 8   343                                                      
REMARK 465     LEU 8   344                                                      
REMARK 465     ILE 8   345                                                      
REMARK 465     PHE 8   346                                                      
REMARK 465     MET 9     1                                                      
REMARK 465     TYR 9     2                                                      
REMARK 465     HIS 9     3                                                      
REMARK 465     ASN 9     4                                                      
REMARK 465     SER 9     5                                                      
REMARK 465     SER 9     6                                                      
REMARK 465     GLN 9     7                                                      
REMARK 465     LYS 9     8                                                      
REMARK 465     ARG 9     9                                                      
REMARK 465     HIS 9    10                                                      
REMARK 465     LEU 9   287                                                      
REMARK 465     ASN 9   288                                                      
REMARK 465     VAL 9   289                                                      
REMARK 465     ILE 9   290                                                      
REMARK 465     THR 9   291                                                      
REMARK 465     LYS 9   292                                                      
REMARK 465     LYS 9   293                                                      
REMARK 465     ARG 9   294                                                      
REMARK 465     LYS 9   295                                                      
REMARK 465     GLY 9   296                                                      
REMARK 465     TYR 9   297                                                      
REMARK 465     GLU 9   298                                                      
REMARK 465     ASP 9   299                                                      
REMARK 465     ASP 9   300                                                      
REMARK 465     ASP 9   301                                                      
REMARK 465     TYR 9   302                                                      
REMARK 465     VAL 9   303                                                      
REMARK 465     SER 9   304                                                      
REMARK 465     LYS 9   305                                                      
REMARK 465     LYS 9   306                                                      
REMARK 465     SER 9   307                                                      
REMARK 465     LYS 9   308                                                      
REMARK 465     HIS 9   309                                                      
REMARK 465     GLU 9   310                                                      
REMARK 465     GLU 9   311                                                      
REMARK 465     GLU 9   312                                                      
REMARK 465     GLU 9   313                                                      
REMARK 465     TRP 9   314                                                      
REMARK 465     THR 9   315                                                      
REMARK 465     ASP 9   316                                                      
REMARK 465     ASP 9   317                                                      
REMARK 465     ASP 9   318                                                      
REMARK 465     LEU 9   319                                                      
REMARK 465     VAL 9   320                                                      
REMARK 465     GLU 9   321                                                      
REMARK 465     SER 9   322                                                      
REMARK 465     LEU 9   323                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ALA K   3    CB                                                  
REMARK 470     PHE R  75    N                                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CE2  TYR 0    59     CG2  THR 0    68              1.76            
REMARK 500   O    SER 0   151     CD   PRO 0   153              1.83            
REMARK 500   CG1  VAL 0    77     CB   ASP 1   268              2.11            
REMARK 500   CB   MET 0    57     OH   TYR 0    94              2.14            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LYS 0  89   N   -  CA  -  C   ANGL. DEV. =  17.5 DEGREES          
REMARK 500    PRO 0 153   C   -  N   -  CA  ANGL. DEV. =   9.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  12       47.80    -94.98                                   
REMARK 500    VAL A  36       -3.34   -142.17                                   
REMARK 500    GLU A  38      -87.76     58.61                                   
REMARK 500    PRO A  44       95.33    -62.53                                   
REMARK 500    THR A  47      -78.74   -141.66                                   
REMARK 500    LYS A  53       46.77    -98.78                                   
REMARK 500    LEU A  54     -127.63     59.22                                   
REMARK 500    LEU A  57      -70.75   -142.54                                   
REMARK 500    ASP A  59       78.14   -155.81                                   
REMARK 500    GLN A  62      -14.88   -140.95                                   
REMARK 500    GLU A  66      155.55     68.97                                   
REMARK 500    ARG A  67       90.87    -62.04                                   
REMARK 500    ARG A  70       86.41     57.59                                   
REMARK 500    CYS A  71       74.40   -150.13                                   
REMARK 500    GLN A  72     -150.44     38.73                                   
REMARK 500    ALA A  75     -158.19     57.35                                   
REMARK 500    ASN A  77     -153.42   -118.19                                   
REMARK 500    PHE A 113      -30.82     66.35                                   
REMARK 500    SER A 115      -58.40     61.90                                   
REMARK 500    ALA A 131      -76.71    -73.99                                   
REMARK 500    GLU A 155      -51.31   -125.21                                   
REMARK 500    ASP A 161      -61.43   -155.59                                   
REMARK 500    VAL A 166     -166.66   -120.46                                   
REMARK 500    LYS A 177     -149.68   -140.87                                   
REMARK 500    HIS A 181       33.10    -88.08                                   
REMARK 500    CYS A 184       79.72     56.30                                   
REMARK 500    ASN A 206      -43.79   -146.98                                   
REMARK 500    GLU A 207       -0.49   -144.18                                   
REMARK 500    ASP A 208       79.16   -150.96                                   
REMARK 500    PRO A 257     -132.00    -77.69                                   
REMARK 500    GLN A 267     -126.92     59.98                                   
REMARK 500    ALA A 270      -91.99   -151.71                                   
REMARK 500    ARG A 271       98.06     59.72                                   
REMARK 500    ASN A 272     -121.87    -78.07                                   
REMARK 500    GLN A 273     -140.10   -138.74                                   
REMARK 500    ASN A 296     -128.18    -95.29                                   
REMARK 500    ALA A 299     -141.36     58.56                                   
REMARK 500    ALA A 300      -42.15   -154.37                                   
REMARK 500    GLU A 321       95.93    -69.67                                   
REMARK 500    GLN A 330     -109.09   -122.90                                   
REMARK 500    SER A 332      -78.95    -68.83                                   
REMARK 500    SER A 338     -129.34     59.11                                   
REMARK 500    LEU A 339      -30.14   -138.78                                   
REMARK 500    VAL A 350      -64.18   -120.22                                   
REMARK 500    ASN A 353      -56.79   -140.58                                   
REMARK 500    LYS A 357     -166.13   -115.63                                   
REMARK 500    PHE A 361       76.41     56.06                                   
REMARK 500    THR A 365     -140.87   -117.66                                   
REMARK 500    ASP A 370       83.00   -157.61                                   
REMARK 500    ASN A 387      -29.76   -142.18                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS    1124 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TYR 0   18     PRO 0   19                   51.49                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A2002  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A  74   SG                                                     
REMARK 620 2 CYS A  81   SG   84.3                                              
REMARK 620 3 HIS A  84   NE2 131.1 128.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A2003  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A 111   SG                                                     
REMARK 620 2 CYS A 184   O   139.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG B1201  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 495   OD1                                                    
REMARK 620 2 GLU B 791   OE1 104.3                                              
REMARK 620 3 GLU B 791   OE2  60.4  43.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG A2001  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 495   OD2                                                    
REMARK 620 2 ASP A 499   OD2 103.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1202  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1119   SG                                                     
REMARK 620 2 CYS B1122   SG  102.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 301  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS C  88   SG                                                     
REMARK 620 2 CYS C  94   SG   87.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN I 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I  20   SG                                                     
REMARK 620 2 CYS I  42   SG   86.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN J 101  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS J  10   SG                                                     
REMARK 620 2 CYS J  44   SG   84.8                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN L 101  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS L  19   SG                                                     
REMARK 620 2 CYS L  36   SG  113.5                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN M 401  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS M  15   SG                                                     
REMARK 620 2 HIS M  18   NE2 123.2                                              
REMARK 620 3 CYS M  37   SG  116.9 109.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN Q 501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS Q 129   SG                                                     
REMARK 620 2 CYS Q 132   SG   95.1                                              
REMARK 620 3 CYS Q 154   SG  148.0  96.8                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN U 401  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS U 263   SG                                                     
REMARK 620 2 CYS U 291   SG   88.9                                              
REMARK 620 3 CYS U 294   SG   90.0 117.5                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 01000  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 0 116   SG                                                     
REMARK 620 2 SF4 01000   S2  122.1                                              
REMARK 620 3 SF4 01000   S3  126.1  76.6                                        
REMARK 620 4 SF4 01000   S4  126.3  98.8  94.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 01000  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 0 134   SG                                                     
REMARK 620 2 SF4 01000   S1  121.9                                              
REMARK 620 3 SF4 01000   S2  140.9  91.0                                        
REMARK 620 4 SF4 01000   S4   70.2  90.9  90.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 01000  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 0 155   SG                                                     
REMARK 620 2 SF4 01000   S1  113.9                                              
REMARK 620 3 SF4 01000   S3  121.8  92.0                                        
REMARK 620 4 SF4 01000   S4  136.7  88.6  92.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 01000  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 0 190   SG                                                     
REMARK 620 2 SF4 01000   S1  113.5                                              
REMARK 620 3 SF4 01000   S2  144.4  97.7                                        
REMARK 620 4 SF4 01000   S3  118.5  91.8  75.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN 3 401  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 3   6   SG                                                     
REMARK 620 2 CYS 3   9   SG   91.2                                              
REMARK 620 3 CYS 3  31   SG  132.1 124.7                                        
REMARK 620 4 CYS 3  34   SG   99.1  93.3 108.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN 3 402  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 3  26   SG                                                     
REMARK 620 2 CYS 3  46   SG  118.6                                              
REMARK 620 3 CYS 3  49   SG  100.2  88.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN 4 401  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 4 271   SG                                                     
REMARK 620 2 CYS 4 285   SG  102.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN 6 401  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 6 345   SG                                                     
REMARK 620 2 CYS 6 348   SG   88.4                                              
REMARK 620 3 CYS 6 368   SG  162.0  87.3                                        
REMARK 620 4 CYS 6 371   SG   99.8  89.9  97.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN 6 402  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS 6 360   SG                                                     
REMARK 620 2 CYS 6 363   SG   87.3                                              
REMARK 620 3 CYS 6 382   SG   93.9  79.8                                        
REMARK 620 4 CYS 6 385   SG  138.7 123.7 116.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG A 2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG B 1201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN C 301                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN I 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN I 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN J 101                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN L 101                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN M 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN Q 501                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN U 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 0 1000                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 3 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 3 402                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 4 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 6 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 6 402                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN 6 403                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-3307   RELATED DB: EMDB                              
REMARK 900 THIS ENTRY 6O9L REFLECTS AN ALTERNATIVE MODELING OF EM DATA EMD-     
REMARK 900 3307.                                                                
DBREF  6O9L A    1  1970  UNP    P24928   RPB1_HUMAN       1   1970             
DBREF  6O9L B    1  1174  UNP    P30876   RPB2_HUMAN       1   1174             
DBREF  6O9L C    1   275  UNP    P19387   RPB3_HUMAN       1    275             
DBREF  6O9L D    1   142  UNP    O15514   RPB4_HUMAN       1    142             
DBREF  6O9L E    1   210  UNP    P19388   RPAB1_HUMAN      1    210             
DBREF  6O9L F    1   127  UNP    P61218   RPAB2_HUMAN      1    127             
DBREF  6O9L G    1   172  UNP    P62487   RPB7_HUMAN       1    172             
DBREF  6O9L H    1   150  UNP    P52434   RPAB3_HUMAN      1    150             
DBREF  6O9L I    1   125  UNP    P36954   RPB9_HUMAN       1    125             
DBREF  6O9L J    1    67  UNP    P62875   RPAB5_HUMAN      1     67             
DBREF  6O9L K    1   117  UNP    P52435   RPB11_HUMAN      1    117             
DBREF  6O9L L    1    58  UNP    P53803   RPAB4_HUMAN      1     58             
DBREF  6O9L M    1   316  UNP    Q00403   TF2B_HUMAN       1    316             
DBREF  6O9L N    1   376  UNP    P52655   TF2AA_HUMAN      1    376             
DBREF  6O9L O    1   109  UNP    P52657   T2AG_HUMAN       1    109             
DBREF  6O9L P    1   339  UNP    P20226   TBP_HUMAN        1    339             
DBREF  6O9L Q    1   439  UNP    P29083   T2EA_HUMAN       1    439             
DBREF  6O9L R    1   291  UNP    P29084   T2EB_HUMAN       1    291             
DBREF  6O9L S    1   517  UNP    P35269   T2FA_HUMAN       1    517             
DBREF  6O9L T    1   249  UNP    P13984   T2FB_HUMAN       1    249             
DBREF  6O9L U    1   301  UNP    P23193   TCEA1_HUMAN      1    301             
DBREF  6O9L 0    1   760  UNP    P18074   ERCC2_HUMAN      1    760             
DBREF  6O9L 1    1   548  UNP    P32780   TF2H1_HUMAN      1    548             
DBREF  6O9L 2    1   462  UNP    Q92759   TF2H4_HUMAN      1    462             
DBREF  6O9L 3    1   309  UNP    P51948   MAT1_HUMAN       1    309             
DBREF  6O9L 4    1   308  UNP    Q13889   TF2H3_HUMAN      1    308             
DBREF  6O9L 5    1    71  UNP    Q6ZYL4   TF2H5_HUMAN      1     71             
DBREF  6O9L 6    1   395  UNP    Q13888   TF2H2_HUMAN      1    395             
DBREF  6O9L 7    1   782  UNP    P19447   ERCC3_HUMAN      1    782             
DBREF  6O9L 8    1   346  UNP    P50613   CDK7_HUMAN       1    346             
DBREF  6O9L 9    1   323  UNP    P51946   CCNH_HUMAN       1    323             
DBREF  6O9L X    1    65  PDB    6O9L     6O9L             1     65             
DBREF  6O9L Y   29    93  PDB    6O9L     6O9L            29     93             
SEQRES   1 A 1970  MET HIS GLY GLY GLY PRO PRO SER GLY ASP SER ALA CYS          
SEQRES   2 A 1970  PRO LEU ARG THR ILE LYS ARG VAL GLN PHE GLY VAL LEU          
SEQRES   3 A 1970  SER PRO ASP GLU LEU LYS ARG MET SER VAL THR GLU GLY          
SEQRES   4 A 1970  GLY ILE LYS TYR PRO GLU THR THR GLU GLY GLY ARG PRO          
SEQRES   5 A 1970  LYS LEU GLY GLY LEU MET ASP PRO ARG GLN GLY VAL ILE          
SEQRES   6 A 1970  GLU ARG THR GLY ARG CYS GLN THR CYS ALA GLY ASN MET          
SEQRES   7 A 1970  THR GLU CYS PRO GLY HIS PHE GLY HIS ILE GLU LEU ALA          
SEQRES   8 A 1970  LYS PRO VAL PHE HIS VAL GLY PHE LEU VAL LYS THR MET          
SEQRES   9 A 1970  LYS VAL LEU ARG CYS VAL CYS PHE PHE CYS SER LYS LEU          
SEQRES  10 A 1970  LEU VAL ASP SER ASN ASN PRO LYS ILE LYS ASP ILE LEU          
SEQRES  11 A 1970  ALA LYS SER LYS GLY GLN PRO LYS LYS ARG LEU THR HIS          
SEQRES  12 A 1970  VAL TYR ASP LEU CYS LYS GLY LYS ASN ILE CYS GLU GLY          
SEQRES  13 A 1970  GLY GLU GLU MET ASP ASN LYS PHE GLY VAL GLU GLN PRO          
SEQRES  14 A 1970  GLU GLY ASP GLU ASP LEU THR LYS GLU LYS GLY HIS GLY          
SEQRES  15 A 1970  GLY CYS GLY ARG TYR GLN PRO ARG ILE ARG ARG SER GLY          
SEQRES  16 A 1970  LEU GLU LEU TYR ALA GLU TRP LYS HIS VAL ASN GLU ASP          
SEQRES  17 A 1970  SER GLN GLU LYS LYS ILE LEU LEU SER PRO GLU ARG VAL          
SEQRES  18 A 1970  HIS GLU ILE PHE LYS ARG ILE SER ASP GLU GLU CYS PHE          
SEQRES  19 A 1970  VAL LEU GLY MET GLU PRO ARG TYR ALA ARG PRO GLU TRP          
SEQRES  20 A 1970  MET ILE VAL THR VAL LEU PRO VAL PRO PRO LEU SER VAL          
SEQRES  21 A 1970  ARG PRO ALA VAL VAL MET GLN GLY SER ALA ARG ASN GLN          
SEQRES  22 A 1970  ASP ASP LEU THR HIS LYS LEU ALA ASP ILE VAL LYS ILE          
SEQRES  23 A 1970  ASN ASN GLN LEU ARG ARG ASN GLU GLN ASN GLY ALA ALA          
SEQRES  24 A 1970  ALA HIS VAL ILE ALA GLU ASP VAL LYS LEU LEU GLN PHE          
SEQRES  25 A 1970  HIS VAL ALA THR MET VAL ASP ASN GLU LEU PRO GLY LEU          
SEQRES  26 A 1970  PRO ARG ALA MET GLN LYS SER GLY ARG PRO LEU LYS SER          
SEQRES  27 A 1970  LEU LYS GLN ARG LEU LYS GLY LYS GLU GLY ARG VAL ARG          
SEQRES  28 A 1970  GLY ASN LEU MET GLY LYS ARG VAL ASP PHE SER ALA ARG          
SEQRES  29 A 1970  THR VAL ILE THR PRO ASP PRO ASN LEU SER ILE ASP GLN          
SEQRES  30 A 1970  VAL GLY VAL PRO ARG SER ILE ALA ALA ASN MET THR PHE          
SEQRES  31 A 1970  ALA GLU ILE VAL THR PRO PHE ASN ILE ASP ARG LEU GLN          
SEQRES  32 A 1970  GLU LEU VAL ARG ARG GLY ASN SER GLN TYR PRO GLY ALA          
SEQRES  33 A 1970  LYS TYR ILE ILE ARG ASP ASN GLY ASP ARG ILE ASP LEU          
SEQRES  34 A 1970  ARG PHE HIS PRO LYS PRO SER ASP LEU HIS LEU GLN THR          
SEQRES  35 A 1970  GLY TYR LYS VAL GLU ARG HIS MET CYS ASP GLY ASP ILE          
SEQRES  36 A 1970  VAL ILE PHE ASN ARG GLN PRO THR LEU HIS LYS MET SER          
SEQRES  37 A 1970  MET MET GLY HIS ARG VAL ARG ILE LEU PRO TRP SER THR          
SEQRES  38 A 1970  PHE ARG LEU ASN LEU SER VAL THR THR PRO TYR ASN ALA          
SEQRES  39 A 1970  ASP PHE ASP GLY ASP GLU MET ASN LEU HIS LEU PRO GLN          
SEQRES  40 A 1970  SER LEU GLU THR ARG ALA GLU ILE GLN GLU LEU ALA MET          
SEQRES  41 A 1970  VAL PRO ARG MET ILE VAL THR PRO GLN SER ASN ARG PRO          
SEQRES  42 A 1970  VAL MET GLY ILE VAL GLN ASP THR LEU THR ALA VAL ARG          
SEQRES  43 A 1970  LYS PHE THR LYS ARG ASP VAL PHE LEU GLU ARG GLY GLU          
SEQRES  44 A 1970  VAL MET ASN LEU LEU MET PHE LEU SER THR TRP ASP GLY          
SEQRES  45 A 1970  LYS VAL PRO GLN PRO ALA ILE LEU LYS PRO ARG PRO LEU          
SEQRES  46 A 1970  TRP THR GLY LYS GLN ILE PHE SER LEU ILE ILE PRO GLY          
SEQRES  47 A 1970  HIS ILE ASN CYS ILE ARG THR HIS SER THR HIS PRO ASP          
SEQRES  48 A 1970  ASP GLU ASP SER GLY PRO TYR LYS HIS ILE SER PRO GLY          
SEQRES  49 A 1970  ASP THR LYS VAL VAL VAL GLU ASN GLY GLU LEU ILE MET          
SEQRES  50 A 1970  GLY ILE LEU CYS LYS LYS SER LEU GLY THR SER ALA GLY          
SEQRES  51 A 1970  SER LEU VAL HIS ILE SER TYR LEU GLU MET GLY HIS ASP          
SEQRES  52 A 1970  ILE THR ARG LEU PHE TYR SER ASN ILE GLN THR VAL ILE          
SEQRES  53 A 1970  ASN ASN TRP LEU LEU ILE GLU GLY HIS THR ILE GLY ILE          
SEQRES  54 A 1970  GLY ASP SER ILE ALA ASP SER LYS THR TYR GLN ASP ILE          
SEQRES  55 A 1970  GLN ASN THR ILE LYS LYS ALA LYS GLN ASP VAL ILE GLU          
SEQRES  56 A 1970  VAL ILE GLU LYS ALA HIS ASN ASN GLU LEU GLU PRO THR          
SEQRES  57 A 1970  PRO GLY ASN THR LEU ARG GLN THR PHE GLU ASN GLN VAL          
SEQRES  58 A 1970  ASN ARG ILE LEU ASN ASP ALA ARG ASP LYS THR GLY SER          
SEQRES  59 A 1970  SER ALA GLN LYS SER LEU SER GLU TYR ASN ASN PHE LYS          
SEQRES  60 A 1970  SER MET VAL VAL SER GLY ALA LYS GLY SER LYS ILE ASN          
SEQRES  61 A 1970  ILE SER GLN VAL ILE ALA VAL VAL GLY GLN GLN ASN VAL          
SEQRES  62 A 1970  GLU GLY LYS ARG ILE PRO PHE GLY PHE LYS HIS ARG THR          
SEQRES  63 A 1970  LEU PRO HIS PHE ILE LYS ASP ASP TYR GLY PRO GLU SER          
SEQRES  64 A 1970  ARG GLY PHE VAL GLU ASN SER TYR LEU ALA GLY LEU THR          
SEQRES  65 A 1970  PRO THR GLU PHE PHE PHE HIS ALA MET GLY GLY ARG GLU          
SEQRES  66 A 1970  GLY LEU ILE ASP THR ALA VAL LYS THR ALA GLU THR GLY          
SEQRES  67 A 1970  TYR ILE GLN ARG ARG LEU ILE LYS SER MET GLU SER VAL          
SEQRES  68 A 1970  MET VAL LYS TYR ASP ALA THR VAL ARG ASN SER ILE ASN          
SEQRES  69 A 1970  GLN VAL VAL GLN LEU ARG TYR GLY GLU ASP GLY LEU ALA          
SEQRES  70 A 1970  GLY GLU SER VAL GLU PHE GLN ASN LEU ALA THR LEU LYS          
SEQRES  71 A 1970  PRO SER ASN LYS ALA PHE GLU LYS LYS PHE ARG PHE ASP          
SEQRES  72 A 1970  TYR THR ASN GLU ARG ALA LEU ARG ARG THR LEU GLN GLU          
SEQRES  73 A 1970  ASP LEU VAL LYS ASP VAL LEU SER ASN ALA HIS ILE GLN          
SEQRES  74 A 1970  ASN GLU LEU GLU ARG GLU PHE GLU ARG MET ARG GLU ASP          
SEQRES  75 A 1970  ARG GLU VAL LEU ARG VAL ILE PHE PRO THR GLY ASP SER          
SEQRES  76 A 1970  LYS VAL VAL LEU PRO CYS ASN LEU LEU ARG MET ILE TRP          
SEQRES  77 A 1970  ASN ALA GLN LYS ILE PHE HIS ILE ASN PRO ARG LEU PRO          
SEQRES  78 A 1970  SER ASP LEU HIS PRO ILE LYS VAL VAL GLU GLY VAL LYS          
SEQRES  79 A 1970  GLU LEU SER LYS LYS LEU VAL ILE VAL ASN GLY ASP ASP          
SEQRES  80 A 1970  PRO LEU SER ARG GLN ALA GLN GLU ASN ALA THR LEU LEU          
SEQRES  81 A 1970  PHE ASN ILE HIS LEU ARG SER THR LEU CYS SER ARG ARG          
SEQRES  82 A 1970  MET ALA GLU GLU PHE ARG LEU SER GLY GLU ALA PHE ASP          
SEQRES  83 A 1970  TRP LEU LEU GLY GLU ILE GLU SER LYS PHE ASN GLN ALA          
SEQRES  84 A 1970  ILE ALA HIS PRO GLY GLU MET VAL GLY ALA LEU ALA ALA          
SEQRES  85 A 1970  GLN SER LEU GLY GLU PRO ALA THR GLN MET THR LEU ASN          
SEQRES  86 A 1970  THR PHE HIS TYR ALA GLY VAL SER ALA LYS ASN VAL THR          
SEQRES  87 A 1970  LEU GLY VAL PRO ARG LEU LYS GLU LEU ILE ASN ILE SER          
SEQRES  88 A 1970  LYS LYS PRO LYS THR PRO SER LEU THR VAL PHE LEU LEU          
SEQRES  89 A 1970  GLY GLN SER ALA ARG ASP ALA GLU ARG ALA LYS ASP ILE          
SEQRES  90 A 1970  LEU CYS ARG LEU GLU HIS THR THR LEU ARG LYS VAL THR          
SEQRES  91 A 1970  ALA ASN THR ALA ILE TYR TYR ASP PRO ASN PRO GLN SER          
SEQRES  92 A 1970  THR VAL VAL ALA GLU ASP GLN GLU TRP VAL ASN VAL TYR          
SEQRES  93 A 1970  TYR GLU MET PRO ASP PHE ASP VAL ALA ARG ILE SER PRO          
SEQRES  94 A 1970  TRP LEU LEU ARG VAL GLU LEU ASP ARG LYS HIS MET THR          
SEQRES  95 A 1970  ASP ARG LYS LEU THR MET GLU GLN ILE ALA GLU LYS ILE          
SEQRES  96 A 1970  ASN ALA GLY PHE GLY ASP ASP LEU ASN CYS ILE PHE ASN          
SEQRES  97 A 1970  ASP ASP ASN ALA GLU LYS LEU VAL LEU ARG ILE ARG ILE          
SEQRES  98 A 1970  MET ASN SER ASP GLU ASN LYS MET GLN GLU GLU GLU GLU          
SEQRES  99 A 1970  VAL VAL ASP LYS MET ASP ASP ASP VAL PHE LEU ARG CYS          
SEQRES 100 A 1970  ILE GLU SER ASN MET LEU THR ASP MET THR LEU GLN GLY          
SEQRES 101 A 1970  ILE GLU GLN ILE SER LYS VAL TYR MET HIS LEU PRO GLN          
SEQRES 102 A 1970  THR ASP ASN LYS LYS LYS ILE ILE ILE THR GLU ASP GLY          
SEQRES 103 A 1970  GLU PHE LYS ALA LEU GLN GLU TRP ILE LEU GLU THR ASP          
SEQRES 104 A 1970  GLY VAL SER LEU MET ARG VAL LEU SER GLU LYS ASP VAL          
SEQRES 105 A 1970  ASP PRO VAL ARG THR THR SER ASN ASP ILE VAL GLU ILE          
SEQRES 106 A 1970  PHE THR VAL LEU GLY ILE GLU ALA VAL ARG LYS ALA LEU          
SEQRES 107 A 1970  GLU ARG GLU LEU TYR HIS VAL ILE SER PHE ASP GLY SER          
SEQRES 108 A 1970  TYR VAL ASN TYR ARG HIS LEU ALA LEU LEU CYS ASP THR          
SEQRES 109 A 1970  MET THR CYS ARG GLY HIS LEU MET ALA ILE THR ARG HIS          
SEQRES 110 A 1970  GLY VAL ASN ARG GLN ASP THR GLY PRO LEU MET LYS CYS          
SEQRES 111 A 1970  SER PHE GLU GLU THR VAL ASP VAL LEU MET GLU ALA ALA          
SEQRES 112 A 1970  ALA HIS GLY GLU SER ASP PRO MET LYS GLY VAL SER GLU          
SEQRES 113 A 1970  ASN ILE MET LEU GLY GLN LEU ALA PRO ALA GLY THR GLY          
SEQRES 114 A 1970  CYS PHE ASP LEU LEU LEU ASP ALA GLU LYS CYS LYS TYR          
SEQRES 115 A 1970  GLY MET GLU ILE PRO THR ASN ILE PRO GLY LEU GLY ALA          
SEQRES 116 A 1970  ALA GLY PRO THR GLY MET PHE PHE GLY SER ALA PRO SER          
SEQRES 117 A 1970  PRO MET GLY GLY ILE SER PRO ALA MET THR PRO TRP ASN          
SEQRES 118 A 1970  GLN GLY ALA THR PRO ALA TYR GLY ALA TRP SER PRO SER          
SEQRES 119 A 1970  VAL GLY SER GLY MET THR PRO GLY ALA ALA GLY PHE SER          
SEQRES 120 A 1970  PRO SER ALA ALA SER ASP ALA SER GLY PHE SER PRO GLY          
SEQRES 121 A 1970  TYR SER PRO ALA TRP SER PRO THR PRO GLY SER PRO GLY          
SEQRES 122 A 1970  SER PRO GLY PRO SER SER PRO TYR ILE PRO SER PRO GLY          
SEQRES 123 A 1970  GLY ALA MET SER PRO SER TYR SER PRO THR SER PRO ALA          
SEQRES 124 A 1970  TYR GLU PRO ARG SER PRO GLY GLY TYR THR PRO GLN SER          
SEQRES 125 A 1970  PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO THR          
SEQRES 126 A 1970  SER PRO SER TYR SER PRO THR SER PRO ASN TYR SER PRO          
SEQRES 127 A 1970  THR SER PRO SER TYR SER PRO THR SER PRO SER TYR SER          
SEQRES 128 A 1970  PRO THR SER PRO SER TYR SER PRO THR SER PRO SER TYR          
SEQRES 129 A 1970  SER PRO THR SER PRO SER TYR SER PRO THR SER PRO SER          
SEQRES 130 A 1970  TYR SER PRO THR SER PRO SER TYR SER PRO THR SER PRO          
SEQRES 131 A 1970  SER TYR SER PRO THR SER PRO SER TYR SER PRO THR SER          
SEQRES 132 A 1970  PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO THR          
SEQRES 133 A 1970  SER PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO          
SEQRES 134 A 1970  THR SER PRO SER TYR SER PRO THR SER PRO SER TYR SER          
SEQRES 135 A 1970  PRO THR SER PRO ASN TYR SER PRO THR SER PRO ASN TYR          
SEQRES 136 A 1970  THR PRO THR SER PRO SER TYR SER PRO THR SER PRO SER          
SEQRES 137 A 1970  TYR SER PRO THR SER PRO ASN TYR THR PRO THR SER PRO          
SEQRES 138 A 1970  ASN TYR SER PRO THR SER PRO SER TYR SER PRO THR SER          
SEQRES 139 A 1970  PRO SER TYR SER PRO THR SER PRO SER TYR SER PRO SER          
SEQRES 140 A 1970  SER PRO ARG TYR THR PRO GLN SER PRO THR TYR THR PRO          
SEQRES 141 A 1970  SER SER PRO SER TYR SER PRO SER SER PRO SER TYR SER          
SEQRES 142 A 1970  PRO ALA SER PRO LYS TYR THR PRO THR SER PRO SER TYR          
SEQRES 143 A 1970  SER PRO SER SER PRO GLU TYR THR PRO THR SER PRO LYS          
SEQRES 144 A 1970  TYR SER PRO THR SER PRO LYS TYR SER PRO THR SER PRO          
SEQRES 145 A 1970  LYS TYR SER PRO THR SER PRO THR TYR SER PRO THR THR          
SEQRES 146 A 1970  PRO LYS TYR SER PRO THR SER PRO THR TYR SER PRO THR          
SEQRES 147 A 1970  SER PRO VAL TYR THR PRO THR SER PRO LYS TYR SER PRO          
SEQRES 148 A 1970  THR SER PRO THR TYR SER PRO THR SER PRO LYS TYR SER          
SEQRES 149 A 1970  PRO THR SER PRO THR TYR SER PRO THR SER PRO LYS GLY          
SEQRES 150 A 1970  SER THR TYR SER PRO THR SER PRO GLY TYR SER PRO THR          
SEQRES 151 A 1970  SER PRO THR TYR SER LEU THR SER PRO ALA ILE SER PRO          
SEQRES 152 A 1970  ASP ASP SER ASP GLU GLU ASN                                  
SEQRES   1 B 1174  MET TYR ASP ALA ASP GLU ASP MET GLN TYR ASP GLU ASP          
SEQRES   2 B 1174  ASP ASP GLU ILE THR PRO ASP LEU TRP GLN GLU ALA CYS          
SEQRES   3 B 1174  TRP ILE VAL ILE SER SER TYR PHE ASP GLU LYS GLY LEU          
SEQRES   4 B 1174  VAL ARG GLN GLN LEU ASP SER PHE ASP GLU PHE ILE GLN          
SEQRES   5 B 1174  MET SER VAL GLN ARG ILE VAL GLU ASP ALA PRO PRO ILE          
SEQRES   6 B 1174  ASP LEU GLN ALA GLU ALA GLN HIS ALA SER GLY GLU VAL          
SEQRES   7 B 1174  GLU GLU PRO PRO ARG TYR LEU LEU LYS PHE GLU GLN ILE          
SEQRES   8 B 1174  TYR LEU SER LYS PRO THR HIS TRP GLU ARG ASP GLY ALA          
SEQRES   9 B 1174  PRO SER PRO MET MET PRO ASN GLU ALA ARG LEU ARG ASN          
SEQRES  10 B 1174  LEU THR TYR SER ALA PRO LEU TYR VAL ASP ILE THR LYS          
SEQRES  11 B 1174  THR VAL ILE LYS GLU GLY GLU GLU GLN LEU GLN THR GLN          
SEQRES  12 B 1174  HIS GLN LYS THR PHE ILE GLY LYS ILE PRO ILE MET LEU          
SEQRES  13 B 1174  ARG SER THR TYR CYS LEU LEU ASN GLY LEU THR ASP ARG          
SEQRES  14 B 1174  ASP LEU CYS GLU LEU ASN GLU CYS PRO LEU ASP PRO GLY          
SEQRES  15 B 1174  GLY TYR PHE ILE ILE ASN GLY SER GLU LYS VAL LEU ILE          
SEQRES  16 B 1174  ALA GLN GLU LYS MET ALA THR ASN THR VAL TYR VAL PHE          
SEQRES  17 B 1174  ALA LYS LYS ASP SER LYS TYR ALA TYR THR GLY GLU CYS          
SEQRES  18 B 1174  ARG SER CYS LEU GLU ASN SER SER ARG PRO THR SER THR          
SEQRES  19 B 1174  ILE TRP VAL SER MET LEU ALA ARG GLY GLY GLN GLY ALA          
SEQRES  20 B 1174  LYS LYS SER ALA ILE GLY GLN ARG ILE VAL ALA THR LEU          
SEQRES  21 B 1174  PRO TYR ILE LYS GLN GLU VAL PRO ILE ILE ILE VAL PHE          
SEQRES  22 B 1174  ARG ALA LEU GLY PHE VAL SER ASP ARG ASP ILE LEU GLU          
SEQRES  23 B 1174  HIS ILE ILE TYR ASP PHE GLU ASP PRO GLU MET MET GLU          
SEQRES  24 B 1174  MET VAL LYS PRO SER LEU ASP GLU ALA PHE VAL ILE GLN          
SEQRES  25 B 1174  GLU GLN ASN VAL ALA LEU ASN PHE ILE GLY SER ARG GLY          
SEQRES  26 B 1174  ALA LYS PRO GLY VAL THR LYS GLU LYS ARG ILE LYS TYR          
SEQRES  27 B 1174  ALA LYS GLU VAL LEU GLN LYS GLU MET LEU PRO HIS VAL          
SEQRES  28 B 1174  GLY VAL SER ASP PHE CYS GLU THR LYS LYS ALA TYR PHE          
SEQRES  29 B 1174  LEU GLY TYR MET VAL HIS ARG LEU LEU LEU ALA ALA LEU          
SEQRES  30 B 1174  GLY ARG ARG GLU LEU ASP ASP ARG ASP HIS TYR GLY ASN          
SEQRES  31 B 1174  LYS ARG LEU ASP LEU ALA GLY PRO LEU LEU ALA PHE LEU          
SEQRES  32 B 1174  PHE ARG GLY MET PHE LYS ASN LEU LEU LYS GLU VAL ARG          
SEQRES  33 B 1174  ILE TYR ALA GLN LYS PHE ILE ASP ARG GLY LYS ASP PHE          
SEQRES  34 B 1174  ASN LEU GLU LEU ALA ILE LYS THR ARG ILE ILE SER ASP          
SEQRES  35 B 1174  GLY LEU LYS TYR SER LEU ALA THR GLY ASN TRP GLY ASP          
SEQRES  36 B 1174  GLN LYS LYS ALA HIS GLN ALA ARG ALA GLY VAL SER GLN          
SEQRES  37 B 1174  VAL LEU ASN ARG LEU THR PHE ALA SER THR LEU SER HIS          
SEQRES  38 B 1174  LEU ARG ARG LEU ASN SER PRO ILE GLY ARG ASP GLY LYS          
SEQRES  39 B 1174  LEU ALA LYS PRO ARG GLN LEU HIS ASN THR LEU TRP GLY          
SEQRES  40 B 1174  MET VAL CYS PRO ALA GLU THR PRO GLU GLY HIS ALA VAL          
SEQRES  41 B 1174  GLY LEU VAL LYS ASN LEU ALA LEU MET ALA TYR ILE SER          
SEQRES  42 B 1174  VAL GLY SER GLN PRO SER PRO ILE LEU GLU PHE LEU GLU          
SEQRES  43 B 1174  GLU TRP SER MET GLU ASN LEU GLU GLU ILE SER PRO ALA          
SEQRES  44 B 1174  ALA ILE ALA ASP ALA THR LYS ILE PHE VAL ASN GLY CYS          
SEQRES  45 B 1174  TRP VAL GLY ILE HIS LYS ASP PRO GLU GLN LEU MET ASN          
SEQRES  46 B 1174  THR LEU ARG LYS LEU ARG ARG GLN MET ASP ILE ILE VAL          
SEQRES  47 B 1174  SER GLU VAL SER MET ILE ARG ASP ILE ARG GLU ARG GLU          
SEQRES  48 B 1174  ILE ARG ILE TYR THR ASP ALA GLY ARG ILE CYS ARG PRO          
SEQRES  49 B 1174  LEU LEU ILE VAL GLU LYS GLN LYS LEU LEU LEU LYS LYS          
SEQRES  50 B 1174  ARG HIS ILE ASP GLN LEU LYS GLU ARG GLU TYR ASN ASN          
SEQRES  51 B 1174  TYR SER TRP GLN ASP LEU VAL ALA SER GLY VAL VAL GLU          
SEQRES  52 B 1174  TYR ILE ASP THR LEU GLU GLU GLU THR VAL MET LEU ALA          
SEQRES  53 B 1174  MET THR PRO ASP ASP LEU GLN GLU LYS GLU VAL ALA TYR          
SEQRES  54 B 1174  CYS SER THR TYR THR HIS CYS GLU ILE HIS PRO SER MET          
SEQRES  55 B 1174  ILE LEU GLY VAL CYS ALA SER ILE ILE PRO PHE PRO ASP          
SEQRES  56 B 1174  HIS ASN GLN SER PRO ARG ASN THR TYR GLN SER ALA MET          
SEQRES  57 B 1174  GLY LYS GLN ALA MET GLY VAL TYR ILE THR ASN PHE HIS          
SEQRES  58 B 1174  VAL ARG MET ASP THR LEU ALA HIS VAL LEU TYR TYR PRO          
SEQRES  59 B 1174  GLN LYS PRO LEU VAL THR THR ARG SER MET GLU TYR LEU          
SEQRES  60 B 1174  ARG PHE ARG GLU LEU PRO ALA GLY ILE ASN SER ILE VAL          
SEQRES  61 B 1174  ALA ILE ALA SER TYR THR GLY TYR ASN GLN GLU ASP SER          
SEQRES  62 B 1174  VAL ILE MET ASN ARG SER ALA VAL ASP ARG GLY PHE PHE          
SEQRES  63 B 1174  ARG SER VAL PHE TYR ARG SER TYR LYS GLU GLN GLU SER          
SEQRES  64 B 1174  LYS LYS GLY PHE ASP GLN GLU GLU VAL PHE GLU LYS PRO          
SEQRES  65 B 1174  THR ARG GLU THR CYS GLN GLY MET ARG HIS ALA ILE TYR          
SEQRES  66 B 1174  ASP LYS LEU ASP ASP ASP GLY LEU ILE ALA PRO GLY VAL          
SEQRES  67 B 1174  ARG VAL SER GLY ASP ASP VAL ILE ILE GLY LYS THR VAL          
SEQRES  68 B 1174  THR LEU PRO GLU ASN GLU ASP GLU LEU GLU SER THR ASN          
SEQRES  69 B 1174  ARG ARG TYR THR LYS ARG ASP CYS SER THR PHE LEU ARG          
SEQRES  70 B 1174  THR SER GLU THR GLY ILE VAL ASP GLN VAL MET VAL THR          
SEQRES  71 B 1174  LEU ASN GLN GLU GLY TYR LYS PHE CYS LYS ILE ARG VAL          
SEQRES  72 B 1174  ARG SER VAL ARG ILE PRO GLN ILE GLY ASP LYS PHE ALA          
SEQRES  73 B 1174  SER ARG HIS GLY GLN LYS GLY THR CYS GLY ILE GLN TYR          
SEQRES  74 B 1174  ARG GLN GLU ASP MET PRO PHE THR CYS GLU GLY ILE THR          
SEQRES  75 B 1174  PRO ASP ILE ILE ILE ASN PRO HIS ALA ILE PRO SER ARG          
SEQRES  76 B 1174  MET THR ILE GLY HIS LEU ILE GLU CYS LEU GLN GLY LYS          
SEQRES  77 B 1174  VAL SER ALA ASN LYS GLY GLU ILE GLY ASP ALA THR PRO          
SEQRES  78 B 1174  PHE ASN ASP ALA VAL ASN VAL GLN LYS ILE SER ASN LEU          
SEQRES  79 B 1174  LEU SER ASP TYR GLY TYR HIS LEU ARG GLY ASN GLU VAL          
SEQRES  80 B 1174  LEU TYR ASN GLY PHE THR GLY ARG LYS ILE THR SER GLN          
SEQRES  81 B 1174  ILE PHE ILE GLY PRO THR TYR TYR GLN ARG LEU LYS HIS          
SEQRES  82 B 1174  MET VAL ASP ASP LYS ILE HIS SER ARG ALA ARG GLY PRO          
SEQRES  83 B 1174  ILE GLN ILE LEU ASN ARG GLN PRO MET GLU GLY ARG SER          
SEQRES  84 B 1174  ARG ASP GLY GLY LEU ARG PHE GLY GLU MET GLU ARG ASP          
SEQRES  85 B 1174  CYS GLN ILE ALA HIS GLY ALA ALA GLN PHE LEU ARG GLU          
SEQRES  86 B 1174  ARG LEU PHE GLU ALA SER ASP PRO TYR GLN VAL HIS VAL          
SEQRES  87 B 1174  CYS ASN LEU CYS GLY ILE MET ALA ILE ALA ASN THR ARG          
SEQRES  88 B 1174  THR HIS THR TYR GLU CYS ARG GLY CYS ARG ASN LYS THR          
SEQRES  89 B 1174  GLN ILE SER LEU VAL ARG MET PRO TYR ALA CYS LYS LEU          
SEQRES  90 B 1174  LEU PHE GLN GLU LEU MET SER MET SER ILE ALA PRO ARG          
SEQRES  91 B 1174  MET MET SER VAL                                              
SEQRES   1 C  275  MET PRO TYR ALA ASN GLN PRO THR VAL ARG ILE THR GLU          
SEQRES   2 C  275  LEU THR ASP GLU ASN VAL LYS PHE ILE ILE GLU ASN THR          
SEQRES   3 C  275  ASP LEU ALA VAL ALA ASN SER ILE ARG ARG VAL PHE ILE          
SEQRES   4 C  275  ALA GLU VAL PRO ILE ILE ALA ILE ASP TRP VAL GLN ILE          
SEQRES   5 C  275  ASP ALA ASN SER SER VAL LEU HIS ASP GLU PHE ILE ALA          
SEQRES   6 C  275  HIS ARG LEU GLY LEU ILE PRO LEU ILE SER ASP ASP ILE          
SEQRES   7 C  275  VAL ASP LYS LEU GLN TYR SER ARG ASP CYS THR CYS GLU          
SEQRES   8 C  275  GLU PHE CYS PRO GLU CYS SER VAL GLU PHE THR LEU ASP          
SEQRES   9 C  275  VAL ARG CYS ASN GLU ASP GLN THR ARG HIS VAL THR SER          
SEQRES  10 C  275  ARG ASP LEU ILE SER ASN SER PRO ARG VAL ILE PRO VAL          
SEQRES  11 C  275  THR SER ARG ASN ARG ASP ASN ASP PRO ASN ASP TYR VAL          
SEQRES  12 C  275  GLU GLN ASP ASP ILE LEU ILE VAL LYS LEU ARG LYS GLY          
SEQRES  13 C  275  GLN GLU LEU ARG LEU ARG ALA TYR ALA LYS LYS GLY PHE          
SEQRES  14 C  275  GLY LYS GLU HIS ALA LYS TRP ASN PRO THR ALA GLY VAL          
SEQRES  15 C  275  ALA PHE GLU TYR ASP PRO ASP ASN ALA LEU ARG HIS THR          
SEQRES  16 C  275  VAL TYR PRO LYS PRO GLU GLU TRP PRO LYS SER GLU TYR          
SEQRES  17 C  275  SER GLU LEU ASP GLU ASP GLU SER GLN ALA PRO TYR ASP          
SEQRES  18 C  275  PRO ASN GLY LYS PRO GLU ARG PHE TYR TYR ASN VAL GLU          
SEQRES  19 C  275  SER CYS GLY SER LEU ARG PRO GLU THR ILE VAL LEU SER          
SEQRES  20 C  275  ALA LEU SER GLY LEU LYS LYS LYS LEU SER ASP LEU GLN          
SEQRES  21 C  275  THR GLN LEU SER HIS GLU ILE GLN SER ASP VAL LEU THR          
SEQRES  22 C  275  ILE ASN                                                      
SEQRES   1 D  142  MET ALA ALA GLY GLY SER ASP PRO ARG ALA GLY ASP VAL          
SEQRES   2 D  142  GLU GLU ASP ALA SER GLN LEU ILE PHE PRO LYS GLU PHE          
SEQRES   3 D  142  GLU THR ALA GLU THR LEU LEU ASN SER GLU VAL HIS MET          
SEQRES   4 D  142  LEU LEU GLU HIS ARG LYS GLN GLN ASN GLU SER ALA GLU          
SEQRES   5 D  142  ASP GLU GLN GLU LEU SER GLU VAL PHE MET LYS THR LEU          
SEQRES   6 D  142  ASN TYR THR ALA ARG PHE SER ARG PHE LYS ASN ARG GLU          
SEQRES   7 D  142  THR ILE ALA SER VAL ARG SER LEU LEU LEU GLN LYS LYS          
SEQRES   8 D  142  LEU HIS LYS PHE GLU LEU ALA CYS LEU ALA ASN LEU CYS          
SEQRES   9 D  142  PRO GLU THR ALA GLU GLU SER LYS ALA LEU ILE PRO SER          
SEQRES  10 D  142  LEU GLU GLY ARG PHE GLU ASP GLU GLU LEU GLN GLN ILE          
SEQRES  11 D  142  LEU ASP ASP ILE GLN THR LYS ARG SER PHE GLN TYR              
SEQRES   1 E  210  MET ASP ASP GLU GLU GLU THR TYR ARG LEU TRP LYS ILE          
SEQRES   2 E  210  ARG LYS THR ILE MET GLN LEU CYS HIS ASP ARG GLY TYR          
SEQRES   3 E  210  LEU VAL THR GLN ASP GLU LEU ASP GLN THR LEU GLU GLU          
SEQRES   4 E  210  PHE LYS ALA GLN SER GLY ASP LYS PRO SER GLU GLY ARG          
SEQRES   5 E  210  PRO ARG ARG THR ASP LEU THR VAL LEU VAL ALA HIS ASN          
SEQRES   6 E  210  ASP ASP PRO THR ASP GLN MET PHE VAL PHE PHE PRO GLU          
SEQRES   7 E  210  GLU PRO LYS VAL GLY ILE LYS THR ILE LYS VAL TYR CYS          
SEQRES   8 E  210  GLN ARG MET GLN GLU GLU ASN ILE THR ARG ALA LEU ILE          
SEQRES   9 E  210  VAL VAL GLN GLN GLY MET THR PRO SER ALA LYS GLN SER          
SEQRES  10 E  210  LEU VAL ASP MET ALA PRO LYS TYR ILE LEU GLU GLN PHE          
SEQRES  11 E  210  LEU GLN GLN GLU LEU LEU ILE ASN ILE THR GLU HIS GLU          
SEQRES  12 E  210  LEU VAL PRO GLU HIS VAL VAL MET THR LYS GLU GLU VAL          
SEQRES  13 E  210  THR GLU LEU LEU ALA ARG TYR LYS LEU ARG GLU ASN GLN          
SEQRES  14 E  210  LEU PRO ARG ILE GLN ALA GLY ASP PRO VAL ALA ARG TYR          
SEQRES  15 E  210  PHE GLY ILE LYS ARG GLY GLN VAL VAL LYS ILE ILE ARG          
SEQRES  16 E  210  PRO SER GLU THR ALA GLY ARG TYR ILE THR TYR ARG LEU          
SEQRES  17 E  210  VAL GLN                                                      
SEQRES   1 F  127  MET SER ASP ASN GLU ASP ASN PHE ASP GLY ASP ASP PHE          
SEQRES   2 F  127  ASP ASP VAL GLU GLU ASP GLU GLY LEU ASP ASP LEU GLU          
SEQRES   3 F  127  ASN ALA GLU GLU GLU GLY GLN GLU ASN VAL GLU ILE LEU          
SEQRES   4 F  127  PRO SER GLY GLU ARG PRO GLN ALA ASN GLN LYS ARG ILE          
SEQRES   5 F  127  THR THR PRO TYR MET THR LYS TYR GLU ARG ALA ARG VAL          
SEQRES   6 F  127  LEU GLY THR ARG ALA LEU GLN ILE ALA MET CYS ALA PRO          
SEQRES   7 F  127  VAL MET VAL GLU LEU GLU GLY GLU THR ASP PRO LEU LEU          
SEQRES   8 F  127  ILE ALA MET LYS GLU LEU LYS ALA ARG LYS ILE PRO ILE          
SEQRES   9 F  127  ILE ILE ARG ARG TYR LEU PRO ASP GLY SER TYR GLU ASP          
SEQRES  10 F  127  TRP GLY VAL ASP GLU LEU ILE ILE THR ASP                      
SEQRES   1 G  172  MET PHE TYR HIS ILE SER LEU GLU HIS GLU ILE LEU LEU          
SEQRES   2 G  172  HIS PRO ARG TYR PHE GLY PRO ASN LEU LEU ASN THR VAL          
SEQRES   3 G  172  LYS GLN LYS LEU PHE THR GLU VAL GLU GLY THR CYS THR          
SEQRES   4 G  172  GLY LYS TYR GLY PHE VAL ILE ALA VAL THR THR ILE ASP          
SEQRES   5 G  172  ASN ILE GLY ALA GLY VAL ILE GLN PRO GLY ARG GLY PHE          
SEQRES   6 G  172  VAL LEU TYR PRO VAL LYS TYR LYS ALA ILE VAL PHE ARG          
SEQRES   7 G  172  PRO PHE LYS GLY GLU VAL VAL ASP ALA VAL VAL THR GLN          
SEQRES   8 G  172  VAL ASN LYS VAL GLY LEU PHE THR GLU ILE GLY PRO MET          
SEQRES   9 G  172  SER CYS PHE ILE SER ARG HIS SER ILE PRO SER GLU MET          
SEQRES  10 G  172  GLU PHE ASP PRO ASN SER ASN PRO PRO CYS TYR LYS THR          
SEQRES  11 G  172  MET ASP GLU ASP ILE VAL ILE GLN GLN ASP ASP GLU ILE          
SEQRES  12 G  172  ARG LEU LYS ILE VAL GLY THR ARG VAL ASP LYS ASN ASP          
SEQRES  13 G  172  ILE PHE ALA ILE GLY SER LEU MET ASP ASP TYR LEU GLY          
SEQRES  14 G  172  LEU VAL SER                                                  
SEQRES   1 H  150  MET ALA GLY ILE LEU PHE GLU ASP ILE PHE ASP VAL LYS          
SEQRES   2 H  150  ASP ILE ASP PRO GLU GLY LYS LYS PHE ASP ARG VAL SER          
SEQRES   3 H  150  ARG LEU HIS CYS GLU SER GLU SER PHE LYS MET ASP LEU          
SEQRES   4 H  150  ILE LEU ASP VAL ASN ILE GLN ILE TYR PRO VAL ASP LEU          
SEQRES   5 H  150  GLY ASP LYS PHE ARG LEU VAL ILE ALA SER THR LEU TYR          
SEQRES   6 H  150  GLU ASP GLY THR LEU ASP ASP GLY GLU TYR ASN PRO THR          
SEQRES   7 H  150  ASP ASP ARG PRO SER ARG ALA ASP GLN PHE GLU TYR VAL          
SEQRES   8 H  150  MET TYR GLY LYS VAL TYR ARG ILE GLU GLY ASP GLU THR          
SEQRES   9 H  150  SER THR GLU ALA ALA THR ARG LEU SER ALA TYR VAL SER          
SEQRES  10 H  150  TYR GLY GLY LEU LEU MET ARG LEU GLN GLY ASP ALA ASN          
SEQRES  11 H  150  ASN LEU HIS GLY PHE GLU VAL ASP SER ARG VAL TYR LEU          
SEQRES  12 H  150  LEU MET LYS LYS LEU ALA PHE                                  
SEQRES   1 I  125  MET GLU PRO ASP GLY THR TYR GLU PRO GLY PHE VAL GLY          
SEQRES   2 I  125  ILE ARG PHE CYS GLN GLU CYS ASN ASN MET LEU TYR PRO          
SEQRES   3 I  125  LYS GLU ASP LYS GLU ASN ARG ILE LEU LEU TYR ALA CYS          
SEQRES   4 I  125  ARG ASN CYS ASP TYR GLN GLN GLU ALA ASP ASN SER CYS          
SEQRES   5 I  125  ILE TYR VAL ASN LYS ILE THR HIS GLU VAL ASP GLU LEU          
SEQRES   6 I  125  THR GLN ILE ILE ALA ASP VAL SER GLN ASP PRO THR LEU          
SEQRES   7 I  125  PRO ARG THR GLU ASP HIS PRO CYS GLN LYS CYS GLY HIS          
SEQRES   8 I  125  LYS GLU ALA VAL PHE PHE GLN SER HIS SER ALA ARG ALA          
SEQRES   9 I  125  GLU ASP ALA MET ARG LEU TYR TYR VAL CYS THR ALA PRO          
SEQRES  10 I  125  HIS CYS GLY HIS ARG TRP THR GLU                              
SEQRES   1 J   67  MET ILE ILE PRO VAL ARG CYS PHE THR CYS GLY LYS ILE          
SEQRES   2 J   67  VAL GLY ASN LYS TRP GLU ALA TYR LEU GLY LEU LEU GLN          
SEQRES   3 J   67  ALA GLU TYR THR GLU GLY ASP ALA LEU ASP ALA LEU GLY          
SEQRES   4 J   67  LEU LYS ARG TYR CYS CYS ARG ARG MET LEU LEU ALA HIS          
SEQRES   5 J   67  VAL ASP LEU ILE GLU LYS LEU LEU ASN TYR ALA PRO LEU          
SEQRES   6 J   67  GLU LYS                                                      
SEQRES   1 K  117  MET ASN ALA PRO PRO ALA PHE GLU SER PHE LEU LEU PHE          
SEQRES   2 K  117  GLU GLY GLU LYS LYS ILE THR ILE ASN LYS ASP THR LYS          
SEQRES   3 K  117  VAL PRO ASN ALA CYS LEU PHE THR ILE ASN LYS GLU ASP          
SEQRES   4 K  117  HIS THR LEU GLY ASN ILE ILE LYS SER GLN LEU LEU LYS          
SEQRES   5 K  117  ASP PRO GLN VAL LEU PHE ALA GLY TYR LYS VAL PRO HIS          
SEQRES   6 K  117  PRO LEU GLU HIS LYS ILE ILE ILE ARG VAL GLN THR THR          
SEQRES   7 K  117  PRO ASP TYR SER PRO GLN GLU ALA PHE THR ASN ALA ILE          
SEQRES   8 K  117  THR ASP LEU ILE SER GLU LEU SER LEU LEU GLU GLU ARG          
SEQRES   9 K  117  PHE ARG VAL ALA ILE LYS ASP LYS GLN GLU GLY ILE GLU          
SEQRES   1 L   58  MET ASP THR GLN LYS ASP VAL GLN PRO PRO LYS GLN GLN          
SEQRES   2 L   58  PRO MET ILE TYR ILE CYS GLY GLU CYS HIS THR GLU ASN          
SEQRES   3 L   58  GLU ILE LYS SER ARG ASP PRO ILE ARG CYS ARG GLU CYS          
SEQRES   4 L   58  GLY TYR ARG ILE MET TYR LYS LYS ARG THR LYS ARG LEU          
SEQRES   5 L   58  VAL VAL PHE ASP ALA ARG                                      
SEQRES   1 M  316  MET ALA SER THR SER ARG LEU ASP ALA LEU PRO ARG VAL          
SEQRES   2 M  316  THR CYS PRO ASN HIS PRO ASP ALA ILE LEU VAL GLU ASP          
SEQRES   3 M  316  TYR ARG ALA GLY ASP MET ILE CYS PRO GLU CYS GLY LEU          
SEQRES   4 M  316  VAL VAL GLY ASP ARG VAL ILE ASP VAL GLY SER GLU TRP          
SEQRES   5 M  316  ARG THR PHE SER ASN ASP LYS ALA THR LYS ASP PRO SER          
SEQRES   6 M  316  ARG VAL GLY ASP SER GLN ASN PRO LEU LEU SER ASP GLY          
SEQRES   7 M  316  ASP LEU SER THR MET ILE GLY LYS GLY THR GLY ALA ALA          
SEQRES   8 M  316  SER PHE ASP GLU PHE GLY ASN SER LYS TYR GLN ASN ARG          
SEQRES   9 M  316  ARG THR MET SER SER SER ASP ARG ALA MET MET ASN ALA          
SEQRES  10 M  316  PHE LYS GLU ILE THR THR MET ALA ASP ARG ILE ASN LEU          
SEQRES  11 M  316  PRO ARG ASN ILE VAL ASP ARG THR ASN ASN LEU PHE LYS          
SEQRES  12 M  316  GLN VAL TYR GLU GLN LYS SER LEU LYS GLY ARG ALA ASN          
SEQRES  13 M  316  ASP ALA ILE ALA SER ALA CYS LEU TYR ILE ALA CYS ARG          
SEQRES  14 M  316  GLN GLU GLY VAL PRO ARG THR PHE LYS GLU ILE CYS ALA          
SEQRES  15 M  316  VAL SER ARG ILE SER LYS LYS GLU ILE GLY ARG CYS PHE          
SEQRES  16 M  316  LYS LEU ILE LEU LYS ALA LEU GLU THR SER VAL ASP LEU          
SEQRES  17 M  316  ILE THR THR GLY ASP PHE MET SER ARG PHE CYS SER ASN          
SEQRES  18 M  316  LEU CYS LEU PRO LYS GLN VAL GLN MET ALA ALA THR HIS          
SEQRES  19 M  316  ILE ALA ARG LYS ALA VAL GLU LEU ASP LEU VAL PRO GLY          
SEQRES  20 M  316  ARG SER PRO ILE SER VAL ALA ALA ALA ALA ILE TYR MET          
SEQRES  21 M  316  ALA SER GLN ALA SER ALA GLU LYS ARG THR GLN LYS GLU          
SEQRES  22 M  316  ILE GLY ASP ILE ALA GLY VAL ALA ASP VAL THR ILE ARG          
SEQRES  23 M  316  GLN SER TYR ARG LEU ILE TYR PRO ARG ALA PRO ASP LEU          
SEQRES  24 M  316  PHE PRO THR ASP PHE LYS PHE ASP THR PRO VAL ASP LYS          
SEQRES  25 M  316  LEU PRO GLN LEU                                              
SEQRES   1 N  376  MET ALA ASN SER ALA ASN THR ASN THR VAL PRO LYS LEU          
SEQRES   2 N  376  TYR ARG SER VAL ILE GLU ASP VAL ILE ASN ASP VAL ARG          
SEQRES   3 N  376  ASP ILE PHE LEU ASP ASP GLY VAL ASP GLU GLN VAL LEU          
SEQRES   4 N  376  MET GLU LEU LYS THR LEU TRP GLU ASN LYS LEU MET GLN          
SEQRES   5 N  376  SER ARG ALA VAL ASP GLY PHE HIS SER GLU GLU GLN GLN          
SEQRES   6 N  376  LEU LEU LEU GLN VAL GLN GLN GLN HIS GLN PRO GLN GLN          
SEQRES   7 N  376  GLN GLN HIS HIS HIS HIS HIS HIS HIS GLN GLN ALA GLN          
SEQRES   8 N  376  PRO GLN GLN THR VAL PRO GLN GLN ALA GLN THR GLN GLN          
SEQRES   9 N  376  VAL LEU ILE PRO ALA SER GLN GLN ALA THR ALA PRO GLN          
SEQRES  10 N  376  VAL ILE VAL PRO ASP SER LYS LEU ILE GLN HIS MET ASN          
SEQRES  11 N  376  ALA SER ASN MET SER ALA ALA ALA THR ALA ALA THR LEU          
SEQRES  12 N  376  ALA LEU PRO ALA GLY VAL THR PRO VAL GLN GLN ILE LEU          
SEQRES  13 N  376  THR ASN SER GLY GLN LEU LEU GLN VAL VAL ARG ALA ALA          
SEQRES  14 N  376  ASN GLY ALA GLN TYR ILE PHE GLN PRO GLN GLN SER VAL          
SEQRES  15 N  376  VAL LEU GLN GLN GLN VAL ILE PRO GLN MET GLN PRO GLY          
SEQRES  16 N  376  GLY VAL GLN ALA PRO VAL ILE GLN GLN VAL LEU ALA PRO          
SEQRES  17 N  376  LEU PRO GLY GLY ILE SER PRO GLN THR GLY VAL ILE ILE          
SEQRES  18 N  376  GLN PRO GLN GLN ILE LEU PHE THR GLY ASN LYS THR GLN          
SEQRES  19 N  376  VAL ILE PRO THR THR VAL ALA ALA PRO THR PRO ALA GLN          
SEQRES  20 N  376  ALA GLN ILE THR ALA THR GLY GLN GLN GLN PRO GLN ALA          
SEQRES  21 N  376  GLN PRO ALA GLN THR GLN ALA PRO LEU VAL LEU GLN VAL          
SEQRES  22 N  376  ASP GLY THR GLY ASP THR SER SER GLU GLU ASP GLU ASP          
SEQRES  23 N  376  GLU GLU GLU ASP TYR ASP ASP ASP GLU GLU GLU ASP LYS          
SEQRES  24 N  376  GLU LYS ASP GLY ALA GLU ASP GLY GLN VAL GLU GLU GLU          
SEQRES  25 N  376  PRO LEU ASN SER GLU ASP ASP VAL SER ASP GLU GLU GLY          
SEQRES  26 N  376  GLN GLU LEU PHE ASP THR GLU ASN VAL VAL VAL CYS GLN          
SEQRES  27 N  376  TYR ASP LYS ILE HIS ARG SER LYS ASN LYS TRP LYS PHE          
SEQRES  28 N  376  HIS LEU LYS ASP GLY ILE MET ASN LEU ASN GLY ARG ASP          
SEQRES  29 N  376  TYR ILE PHE SER LYS ALA ILE GLY ASP ALA GLU TRP              
SEQRES   1 O  109  MET ALA TYR GLN LEU TYR ARG ASN THR THR LEU GLY ASN          
SEQRES   2 O  109  SER LEU GLN GLU SER LEU ASP GLU LEU ILE GLN SER GLN          
SEQRES   3 O  109  GLN ILE THR PRO GLN LEU ALA LEU GLN VAL LEU LEU GLN          
SEQRES   4 O  109  PHE ASP LYS ALA ILE ASN ALA ALA LEU ALA GLN ARG VAL          
SEQRES   5 O  109  ARG ASN ARG VAL ASN PHE ARG GLY SER LEU ASN THR TYR          
SEQRES   6 O  109  ARG PHE CYS ASP ASN VAL TRP THR PHE VAL LEU ASN ASP          
SEQRES   7 O  109  VAL GLU PHE ARG GLU VAL THR GLU LEU ILE LYS VAL ASP          
SEQRES   8 O  109  LYS VAL LYS ILE VAL ALA CYS ASP GLY LYS ASN THR GLY          
SEQRES   9 O  109  SER ASN THR THR GLU                                          
SEQRES   1 P  339  MET ASP GLN ASN ASN SER LEU PRO PRO TYR ALA GLN GLY          
SEQRES   2 P  339  LEU ALA SER PRO GLN GLY ALA MET THR PRO GLY ILE PRO          
SEQRES   3 P  339  ILE PHE SER PRO MET MET PRO TYR GLY THR GLY LEU THR          
SEQRES   4 P  339  PRO GLN PRO ILE GLN ASN THR ASN SER LEU SER ILE LEU          
SEQRES   5 P  339  GLU GLU GLN GLN ARG GLN GLN GLN GLN GLN GLN GLN GLN          
SEQRES   6 P  339  GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN          
SEQRES   7 P  339  GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN          
SEQRES   8 P  339  GLN GLN GLN GLN ALA VAL ALA ALA ALA ALA VAL GLN GLN          
SEQRES   9 P  339  SER THR SER GLN GLN ALA THR GLN GLY THR SER GLY GLN          
SEQRES  10 P  339  ALA PRO GLN LEU PHE HIS SER GLN THR LEU THR THR ALA          
SEQRES  11 P  339  PRO LEU PRO GLY THR THR PRO LEU TYR PRO SER PRO MET          
SEQRES  12 P  339  THR PRO MET THR PRO ILE THR PRO ALA THR PRO ALA SER          
SEQRES  13 P  339  GLU SER SER GLY ILE VAL PRO GLN LEU GLN ASN ILE VAL          
SEQRES  14 P  339  SER THR VAL ASN LEU GLY CYS LYS LEU ASP LEU LYS THR          
SEQRES  15 P  339  ILE ALA LEU ARG ALA ARG ASN ALA GLU TYR ASN PRO LYS          
SEQRES  16 P  339  ARG PHE ALA ALA VAL ILE MET ARG ILE ARG GLU PRO ARG          
SEQRES  17 P  339  THR THR ALA LEU ILE PHE SER SER GLY LYS MET VAL CYS          
SEQRES  18 P  339  THR GLY ALA LYS SER GLU GLU GLN SER ARG LEU ALA ALA          
SEQRES  19 P  339  ARG LYS TYR ALA ARG VAL VAL GLN LYS LEU GLY PHE PRO          
SEQRES  20 P  339  ALA LYS PHE LEU ASP PHE LYS ILE GLN ASN MET VAL GLY          
SEQRES  21 P  339  SER CYS ASP VAL LYS PHE PRO ILE ARG LEU GLU GLY LEU          
SEQRES  22 P  339  VAL LEU THR HIS GLN GLN PHE SER SER TYR GLU PRO GLU          
SEQRES  23 P  339  LEU PHE PRO GLY LEU ILE TYR ARG MET ILE LYS PRO ARG          
SEQRES  24 P  339  ILE VAL LEU LEU ILE PHE VAL SER GLY LYS VAL VAL LEU          
SEQRES  25 P  339  THR GLY ALA LYS VAL ARG ALA GLU ILE TYR GLU ALA PHE          
SEQRES  26 P  339  GLU ASN ILE TYR PRO ILE LEU LYS GLY PHE ARG LYS THR          
SEQRES  27 P  339  THR                                                          
SEQRES   1 Q  439  MET ALA ASP PRO ASP VAL LEU THR GLU VAL PRO ALA ALA          
SEQRES   2 Q  439  LEU LYS ARG LEU ALA LYS TYR VAL ILE ARG GLY PHE TYR          
SEQRES   3 Q  439  GLY ILE GLU HIS ALA LEU ALA LEU ASP ILE LEU ILE ARG          
SEQRES   4 Q  439  ASN SER CYS VAL LYS GLU GLU ASP MET LEU GLU LEU LEU          
SEQRES   5 Q  439  LYS PHE ASP ARG LYS GLN LEU ARG SER VAL LEU ASN ASN          
SEQRES   6 Q  439  LEU LYS GLY ASP LYS PHE ILE LYS CYS ARG MET ARG VAL          
SEQRES   7 Q  439  GLU THR ALA ALA ASP GLY LYS THR THR ARG HIS ASN TYR          
SEQRES   8 Q  439  TYR PHE ILE ASN TYR ARG THR LEU VAL ASN VAL VAL LYS          
SEQRES   9 Q  439  TYR LYS LEU ASP HIS MET ARG ARG ARG ILE GLU THR ASP          
SEQRES  10 Q  439  GLU ARG ASP SER THR ASN ARG ALA SER PHE LYS CYS PRO          
SEQRES  11 Q  439  VAL CYS SER SER THR PHE THR ASP LEU GLU ALA ASN GLN          
SEQRES  12 Q  439  LEU PHE ASP PRO MET THR GLY THR PHE ARG CYS THR PHE          
SEQRES  13 Q  439  CYS HIS THR GLU VAL GLU GLU ASP GLU SER ALA MET PRO          
SEQRES  14 Q  439  LYS LYS ASP ALA ARG THR LEU LEU ALA ARG PHE ASN GLU          
SEQRES  15 Q  439  GLN ILE GLU PRO ILE TYR ALA LEU LEU ARG GLU THR GLU          
SEQRES  16 Q  439  ASP VAL ASN LEU ALA TYR GLU ILE LEU GLU PRO GLU PRO          
SEQRES  17 Q  439  THR GLU ILE PRO ALA LEU LYS GLN SER LYS ASP HIS ALA          
SEQRES  18 Q  439  ALA THR THR ALA GLY ALA ALA SER LEU ALA GLY GLY HIS          
SEQRES  19 Q  439  HIS ARG GLU ALA TRP ALA THR LYS GLY PRO SER TYR GLU          
SEQRES  20 Q  439  ASP LEU TYR THR GLN ASN VAL VAL ILE ASN MET ASP ASP          
SEQRES  21 Q  439  GLN GLU ASP LEU HIS ARG ALA SER LEU GLU GLY LYS SER          
SEQRES  22 Q  439  ALA LYS GLU ARG PRO ILE TRP LEU ARG GLU SER THR VAL          
SEQRES  23 Q  439  GLN GLY ALA TYR GLY SER GLU ASP MET LYS GLU GLY GLY          
SEQRES  24 Q  439  ILE ASP MET ASP ALA PHE GLN GLU ARG GLU GLU GLY HIS          
SEQRES  25 Q  439  ALA GLY PRO ASP ASP ASN GLU GLU VAL MET ARG ALA LEU          
SEQRES  26 Q  439  LEU ILE HIS GLU LYS LYS THR SER SER ALA MET ALA GLY          
SEQRES  27 Q  439  SER VAL GLY ALA ALA ALA PRO VAL THR ALA ALA ASN GLY          
SEQRES  28 Q  439  SER ASP SER GLU SER GLU THR SER GLU SER ASP ASP ASP          
SEQRES  29 Q  439  SER PRO PRO ARG PRO ALA ALA VAL ALA VAL HIS LYS ARG          
SEQRES  30 Q  439  GLU GLU ASP GLU GLU GLU ASP ASP GLU PHE GLU GLU VAL          
SEQRES  31 Q  439  ALA ASP ASP PRO ILE VAL MET VAL ALA GLY ARG PRO PHE          
SEQRES  32 Q  439  SER TYR SER GLU VAL SER GLN ARG PRO GLU LEU VAL ALA          
SEQRES  33 Q  439  GLN MET THR PRO GLU GLU LYS GLU ALA TYR ILE ALA MET          
SEQRES  34 Q  439  GLY GLN ARG MET PHE GLU ASP LEU PHE GLU                      
SEQRES   1 R  291  MET ASP PRO SER LEU LEU ARG GLU ARG GLU LEU PHE LYS          
SEQRES   2 R  291  LYS ARG ALA LEU SER THR PRO VAL VAL GLU LYS ARG SER          
SEQRES   3 R  291  ALA SER SER GLU SER SER SER SER SER SER LYS LYS LYS          
SEQRES   4 R  291  LYS THR LYS VAL GLU HIS GLY GLY SER SER GLY SER LYS          
SEQRES   5 R  291  GLN ASN SER ASP HIS SER ASN GLY SER PHE ASN LEU LYS          
SEQRES   6 R  291  ALA LEU SER GLY SER SER GLY TYR LYS PHE GLY VAL LEU          
SEQRES   7 R  291  ALA LYS ILE VAL ASN TYR MET LYS THR ARG HIS GLN ARG          
SEQRES   8 R  291  GLY ASP THR HIS PRO LEU THR LEU ASP GLU ILE LEU ASP          
SEQRES   9 R  291  GLU THR GLN HIS LEU ASP ILE GLY LEU LYS GLN LYS GLN          
SEQRES  10 R  291  TRP LEU MET THR GLU ALA LEU VAL ASN ASN PRO LYS ILE          
SEQRES  11 R  291  GLU VAL ILE ASP GLY LYS TYR ALA PHE LYS PRO LYS TYR          
SEQRES  12 R  291  ASN VAL ARG ASP LYS LYS ALA LEU LEU ARG LEU LEU ASP          
SEQRES  13 R  291  GLN HIS ASP GLN ARG GLY LEU GLY GLY ILE LEU LEU GLU          
SEQRES  14 R  291  ASP ILE GLU GLU ALA LEU PRO ASN SER GLN LYS ALA VAL          
SEQRES  15 R  291  LYS ALA LEU GLY ASP GLN ILE LEU PHE VAL ASN ARG PRO          
SEQRES  16 R  291  ASP LYS LYS LYS ILE LEU PHE PHE ASN ASP LYS SER CYS          
SEQRES  17 R  291  GLN PHE SER VAL ASP GLU GLU PHE GLN LYS LEU TRP ARG          
SEQRES  18 R  291  SER VAL THR VAL ASP SER MET ASP GLU GLU LYS ILE GLU          
SEQRES  19 R  291  GLU TYR LEU LYS ARG GLN GLY ILE SER SER MET GLN GLU          
SEQRES  20 R  291  SER GLY PRO LYS LYS VAL ALA PRO ILE GLN ARG ARG LYS          
SEQRES  21 R  291  LYS PRO ALA SER GLN LYS LYS ARG ARG PHE LYS THR HIS          
SEQRES  22 R  291  ASN GLU HIS LEU ALA GLY VAL LEU LYS ASP TYR SER ASP          
SEQRES  23 R  291  ILE THR SER SER LYS                                          
SEQRES   1 S  517  MET ALA ALA LEU GLY PRO SER SER GLN ASN VAL THR GLU          
SEQRES   2 S  517  TYR VAL VAL ARG VAL PRO LYS ASN THR THR LYS LYS TYR          
SEQRES   3 S  517  ASN ILE MET ALA PHE ASN ALA ALA ASP LYS VAL ASN PHE          
SEQRES   4 S  517  ALA THR TRP ASN GLN ALA ARG LEU GLU ARG ASP LEU SER          
SEQRES   5 S  517  ASN LYS LYS ILE TYR GLN GLU GLU GLU MET PRO GLU SER          
SEQRES   6 S  517  GLY ALA GLY SER GLU PHE ASN ARG LYS LEU ARG GLU GLU          
SEQRES   7 S  517  ALA ARG ARG LYS LYS TYR GLY ILE VAL LEU LYS GLU PHE          
SEQRES   8 S  517  ARG PRO GLU ASP GLN PRO TRP LEU LEU ARG VAL ASN GLY          
SEQRES   9 S  517  LYS SER GLY ARG LYS PHE LYS GLY ILE LYS LYS GLY GLY          
SEQRES  10 S  517  VAL THR GLU ASN THR SER TYR TYR ILE PHE THR GLN CYS          
SEQRES  11 S  517  PRO ASP GLY ALA PHE GLU ALA PHE PRO VAL HIS ASN TRP          
SEQRES  12 S  517  TYR ASN PHE THR PRO LEU ALA ARG HIS ARG THR LEU THR          
SEQRES  13 S  517  ALA GLU GLU ALA GLU GLU GLU TRP GLU ARG ARG ASN LYS          
SEQRES  14 S  517  VAL LEU ASN HIS PHE SER ILE MET GLN GLN ARG ARG LEU          
SEQRES  15 S  517  LYS ASP GLN ASP GLN ASP GLU ASP GLU GLU GLU LYS GLU          
SEQRES  16 S  517  LYS ARG GLY ARG ARG LYS ALA SER GLU LEU ARG ILE HIS          
SEQRES  17 S  517  ASP LEU GLU ASP ASP LEU GLU MET SER SER ASP ALA SER          
SEQRES  18 S  517  ASP ALA SER GLY GLU GLU GLY GLY ARG VAL PRO LYS ALA          
SEQRES  19 S  517  LYS LYS LYS ALA PRO LEU ALA LYS GLY GLY ARG LYS LYS          
SEQRES  20 S  517  LYS LYS LYS LYS GLY SER ASP ASP GLU ALA PHE GLU ASP          
SEQRES  21 S  517  SER ASP ASP GLY ASP PHE GLU GLY GLN GLU VAL ASP TYR          
SEQRES  22 S  517  MET SER ASP GLY SER SER SER SER GLN GLU GLU PRO GLU          
SEQRES  23 S  517  SER LYS ALA LYS ALA PRO GLN GLN GLU GLU GLY PRO LYS          
SEQRES  24 S  517  GLY VAL ASP GLU GLN SER ASP SER SER GLU GLU SER GLU          
SEQRES  25 S  517  GLU GLU LYS PRO PRO GLU GLU ASP LYS GLU GLU GLU GLU          
SEQRES  26 S  517  GLU LYS LYS ALA PRO THR PRO GLN GLU LYS LYS ARG ARG          
SEQRES  27 S  517  LYS ASP SER SER GLU GLU SER ASP SER SER GLU GLU SER          
SEQRES  28 S  517  ASP ILE ASP SER GLU ALA SER SER ALA LEU PHE MET ALA          
SEQRES  29 S  517  LYS LYS LYS THR PRO PRO LYS ARG GLU ARG LYS PRO SER          
SEQRES  30 S  517  GLY GLY SER SER ARG GLY ASN SER ARG PRO GLY THR PRO          
SEQRES  31 S  517  SER ALA GLU GLY GLY SER THR SER SER THR LEU ARG ALA          
SEQRES  32 S  517  ALA ALA SER LYS LEU GLU GLN GLY LYS ARG VAL SER GLU          
SEQRES  33 S  517  MET PRO ALA ALA LYS ARG LEU ARG LEU ASP THR GLY PRO          
SEQRES  34 S  517  GLN SER LEU SER GLY LYS SER THR PRO GLN PRO PRO SER          
SEQRES  35 S  517  GLY LYS THR THR PRO ASN SER GLY ASP VAL GLN VAL THR          
SEQRES  36 S  517  GLU ASP ALA VAL ARG ARG TYR LEU THR ARG LYS PRO MET          
SEQRES  37 S  517  THR THR LYS ASP LEU LEU LYS LYS PHE GLN THR LYS LYS          
SEQRES  38 S  517  THR GLY LEU SER SER GLU GLN THR VAL ASN VAL LEU ALA          
SEQRES  39 S  517  GLN ILE LEU LYS ARG LEU ASN PRO GLU ARG LYS MET ILE          
SEQRES  40 S  517  ASN ASP LYS MET HIS PHE SER LEU LYS GLU                      
SEQRES   1 T  249  MET ALA GLU ARG GLY GLU LEU ASP LEU THR GLY ALA LYS          
SEQRES   2 T  249  GLN ASN THR GLY VAL TRP LEU VAL LYS VAL PRO LYS TYR          
SEQRES   3 T  249  LEU SER GLN GLN TRP ALA LYS ALA SER GLY ARG GLY GLU          
SEQRES   4 T  249  VAL GLY LYS LEU ARG ILE ALA LYS THR GLN GLY ARG THR          
SEQRES   5 T  249  GLU VAL SER PHE THR LEU ASN GLU ASP LEU ALA ASN ILE          
SEQRES   6 T  249  HIS ASP ILE GLY GLY LYS PRO ALA SER VAL SER ALA PRO          
SEQRES   7 T  249  ARG GLU HIS PRO PHE VAL LEU GLN SER VAL GLY GLY GLN          
SEQRES   8 T  249  THR LEU THR VAL PHE THR GLU SER SER SER ASP LYS LEU          
SEQRES   9 T  249  SER LEU GLU GLY ILE VAL VAL GLN ARG ALA GLU CYS ARG          
SEQRES  10 T  249  PRO ALA ALA SER GLU ASN TYR MET ARG LEU LYS ARG LEU          
SEQRES  11 T  249  GLN ILE GLU GLU SER SER LYS PRO VAL ARG LEU SER GLN          
SEQRES  12 T  249  GLN LEU ASP LYS VAL VAL THR THR ASN TYR LYS PRO VAL          
SEQRES  13 T  249  ALA ASN HIS GLN TYR ASN ILE GLU TYR GLU ARG LYS LYS          
SEQRES  14 T  249  LYS GLU ASP GLY LYS ARG ALA ARG ALA ASP LYS GLN HIS          
SEQRES  15 T  249  VAL LEU ASP MET LEU PHE SER ALA PHE GLU LYS HIS GLN          
SEQRES  16 T  249  TYR TYR ASN LEU LYS ASP LEU VAL ASP ILE THR LYS GLN          
SEQRES  17 T  249  PRO VAL VAL TYR LEU LYS GLU ILE LEU LYS GLU ILE GLY          
SEQRES  18 T  249  VAL GLN ASN VAL LYS GLY ILE HIS LYS ASN THR TRP GLU          
SEQRES  19 T  249  LEU LYS PRO GLU TYR ARG HIS TYR GLN GLY GLU GLU LYS          
SEQRES  20 T  249  SER ASP                                                      
SEQRES   1 U  301  MET GLU ASP GLU VAL VAL ARG PHE ALA LYS LYS MET ASP          
SEQRES   2 U  301  LYS MET VAL GLN LYS LYS ASN ALA ALA GLY ALA LEU ASP          
SEQRES   3 U  301  LEU LEU LYS GLU LEU LYS ASN ILE PRO MET THR LEU GLU          
SEQRES   4 U  301  LEU LEU GLN SER THR ARG ILE GLY MET SER VAL ASN ALA          
SEQRES   5 U  301  ILE ARG LYS GLN SER THR ASP GLU GLU VAL THR SER LEU          
SEQRES   6 U  301  ALA LYS SER LEU ILE LYS SER TRP LYS LYS LEU LEU ASP          
SEQRES   7 U  301  GLY PRO SER THR GLU LYS ASP LEU ASP GLU LYS LYS LYS          
SEQRES   8 U  301  GLU PRO ALA ILE THR SER GLN ASN SER PRO GLU ALA ARG          
SEQRES   9 U  301  GLU GLU SER THR SER SER GLY ASN VAL SER ASN ARG LYS          
SEQRES  10 U  301  ASP GLU THR ASN ALA ARG ASP THR TYR VAL SER SER PHE          
SEQRES  11 U  301  PRO ARG ALA PRO SER THR SER ASP SER VAL ARG LEU LYS          
SEQRES  12 U  301  CYS ARG GLU MET LEU ALA ALA ALA LEU ARG THR GLY ASP          
SEQRES  13 U  301  ASP TYR ILE ALA ILE GLY ALA ASP GLU GLU GLU LEU GLY          
SEQRES  14 U  301  SER GLN ILE GLU GLU ALA ILE TYR GLN GLU ILE ARG ASN          
SEQRES  15 U  301  THR ASP MET LYS TYR LYS ASN ARG VAL ARG SER ARG ILE          
SEQRES  16 U  301  SER ASN LEU LYS ASP ALA LYS ASN PRO ASN LEU ARG LYS          
SEQRES  17 U  301  ASN VAL LEU CYS GLY ASN ILE PRO PRO ASP LEU PHE ALA          
SEQRES  18 U  301  ARG MET THR ALA GLU GLU MET ALA SER ASP GLU LEU LYS          
SEQRES  19 U  301  GLU MET ARG LYS ASN LEU THR LYS GLU ALA ILE ARG GLU          
SEQRES  20 U  301  HIS GLN MET ALA LYS THR GLY GLY THR GLN THR ASP LEU          
SEQRES  21 U  301  PHE THR CYS GLY LYS CYS LYS LYS LYS ASN CYS THR TYR          
SEQRES  22 U  301  THR GLN VAL GLN THR ARG SER ALA ASP GLU PRO MET THR          
SEQRES  23 U  301  THR PHE VAL VAL CYS ASN GLU CYS GLY ASN ARG TRP LYS          
SEQRES  24 U  301  PHE CYS                                                      
SEQRES   1 0  760  MET LYS LEU ASN VAL ASP GLY LEU LEU VAL TYR PHE PRO          
SEQRES   2 0  760  TYR ASP TYR ILE TYR PRO GLU GLN PHE SER TYR MET ARG          
SEQRES   3 0  760  GLU LEU LYS ARG THR LEU ASP ALA LYS GLY HIS GLY VAL          
SEQRES   4 0  760  LEU GLU MET PRO SER GLY THR GLY LYS THR VAL SER LEU          
SEQRES   5 0  760  LEU ALA LEU ILE MET ALA TYR GLN ARG ALA TYR PRO LEU          
SEQRES   6 0  760  GLU VAL THR LYS LEU ILE TYR CYS SER ARG THR VAL PRO          
SEQRES   7 0  760  GLU ILE GLU LYS VAL ILE GLU GLU LEU ARG LYS LEU LEU          
SEQRES   8 0  760  ASN PHE TYR GLU LYS GLN GLU GLY GLU LYS LEU PRO PHE          
SEQRES   9 0  760  LEU GLY LEU ALA LEU SER SER ARG LYS ASN LEU CYS ILE          
SEQRES  10 0  760  HIS PRO GLU VAL THR PRO LEU ARG PHE GLY LYS ASP VAL          
SEQRES  11 0  760  ASP GLY LYS CYS HIS SER LEU THR ALA SER TYR VAL ARG          
SEQRES  12 0  760  ALA GLN TYR GLN HIS ASP THR SER LEU PRO HIS CYS ARG          
SEQRES  13 0  760  PHE TYR GLU GLU PHE ASP ALA HIS GLY ARG GLU VAL PRO          
SEQRES  14 0  760  LEU PRO ALA GLY ILE TYR ASN LEU ASP ASP LEU LYS ALA          
SEQRES  15 0  760  LEU GLY ARG ARG GLN GLY TRP CYS PRO TYR PHE LEU ALA          
SEQRES  16 0  760  ARG TYR SER ILE LEU HIS ALA ASN VAL VAL VAL TYR SER          
SEQRES  17 0  760  TYR HIS TYR LEU LEU ASP PRO LYS ILE ALA ASP LEU VAL          
SEQRES  18 0  760  SER LYS GLU LEU ALA ARG LYS ALA VAL VAL VAL PHE ASP          
SEQRES  19 0  760  GLU ALA HIS ASN ILE ASP ASN VAL CYS ILE ASP SER MET          
SEQRES  20 0  760  SER VAL ASN LEU THR ARG ARG THR LEU ASP ARG CYS GLN          
SEQRES  21 0  760  GLY ASN LEU GLU THR LEU GLN LYS THR VAL LEU ARG ILE          
SEQRES  22 0  760  LYS GLU THR ASP GLU GLN ARG LEU ARG ASP GLU TYR ARG          
SEQRES  23 0  760  ARG LEU VAL GLU GLY LEU ARG GLU ALA SER ALA ALA ARG          
SEQRES  24 0  760  GLU THR ASP ALA HIS LEU ALA ASN PRO VAL LEU PRO ASP          
SEQRES  25 0  760  GLU VAL LEU GLN GLU ALA VAL PRO GLY SER ILE ARG THR          
SEQRES  26 0  760  ALA GLU HIS PHE LEU GLY PHE LEU ARG ARG LEU LEU GLU          
SEQRES  27 0  760  TYR VAL LYS TRP ARG LEU ARG VAL GLN HIS VAL VAL GLN          
SEQRES  28 0  760  GLU SER PRO PRO ALA PHE LEU SER GLY LEU ALA GLN ARG          
SEQRES  29 0  760  VAL CYS ILE GLN ARG LYS PRO LEU ARG PHE CYS ALA GLU          
SEQRES  30 0  760  ARG LEU ARG SER LEU LEU HIS THR LEU GLU ILE THR ASP          
SEQRES  31 0  760  LEU ALA ASP PHE SER PRO LEU THR LEU LEU ALA ASN PHE          
SEQRES  32 0  760  ALA THR LEU VAL SER THR TYR ALA LYS GLY PHE THR ILE          
SEQRES  33 0  760  ILE ILE GLU PRO PHE ASP ASP ARG THR PRO THR ILE ALA          
SEQRES  34 0  760  ASN PRO ILE LEU HIS PHE SER CYS MET ASP ALA SER LEU          
SEQRES  35 0  760  ALA ILE LYS PRO VAL PHE GLU ARG PHE GLN SER VAL ILE          
SEQRES  36 0  760  ILE THR SER GLY THR LEU SER PRO LEU ASP ILE TYR PRO          
SEQRES  37 0  760  LYS ILE LEU ASP PHE HIS PRO VAL THR MET ALA THR PHE          
SEQRES  38 0  760  THR MET THR LEU ALA ARG VAL CYS LEU CYS PRO MET ILE          
SEQRES  39 0  760  ILE GLY ARG GLY ASN ASP GLN VAL ALA ILE SER SER LYS          
SEQRES  40 0  760  PHE GLU THR ARG GLU ASP ILE ALA VAL ILE ARG ASN TYR          
SEQRES  41 0  760  GLY ASN LEU LEU LEU GLU MET SER ALA VAL VAL PRO ASP          
SEQRES  42 0  760  GLY ILE VAL ALA PHE PHE THR SER TYR GLN TYR MET GLU          
SEQRES  43 0  760  SER THR VAL ALA SER TRP TYR GLU GLN GLY ILE LEU GLU          
SEQRES  44 0  760  ASN ILE GLN ARG ASN LYS LEU LEU PHE ILE GLU THR GLN          
SEQRES  45 0  760  ASP GLY ALA GLU THR SER VAL ALA LEU GLU LYS TYR GLN          
SEQRES  46 0  760  GLU ALA CYS GLU ASN GLY ARG GLY ALA ILE LEU LEU SER          
SEQRES  47 0  760  VAL ALA ARG GLY LYS VAL SER GLU GLY ILE ASP PHE VAL          
SEQRES  48 0  760  HIS HIS TYR GLY ARG ALA VAL ILE MET PHE GLY VAL PRO          
SEQRES  49 0  760  TYR VAL TYR THR GLN SER ARG ILE LEU LYS ALA ARG LEU          
SEQRES  50 0  760  GLU TYR LEU ARG ASP GLN PHE GLN ILE ARG GLU ASN ASP          
SEQRES  51 0  760  PHE LEU THR PHE ASP ALA MET ARG HIS ALA ALA GLN CYS          
SEQRES  52 0  760  VAL GLY ARG ALA ILE ARG GLY LYS THR ASP TYR GLY LEU          
SEQRES  53 0  760  MET VAL PHE ALA ASP LYS ARG PHE ALA ARG GLY ASP LYS          
SEQRES  54 0  760  ARG GLY LYS LEU PRO ARG TRP ILE GLN GLU HIS LEU THR          
SEQRES  55 0  760  ASP ALA ASN LEU ASN LEU THR VAL ASP GLU GLY VAL GLN          
SEQRES  56 0  760  VAL ALA LYS TYR PHE LEU ARG GLN MET ALA GLN PRO PHE          
SEQRES  57 0  760  HIS ARG GLU ASP GLN LEU GLY LEU SER LEU LEU SER LEU          
SEQRES  58 0  760  GLU GLN LEU GLU SER GLU GLU THR LEU LYS ARG ILE GLU          
SEQRES  59 0  760  GLN ILE ALA GLN GLN LEU                                      
SEQRES   1 1  548  MET ALA THR SER SER GLU GLU VAL LEU LEU ILE VAL LYS          
SEQRES   2 1  548  LYS VAL ARG GLN LYS LYS GLN ASP GLY ALA LEU TYR LEU          
SEQRES   3 1  548  MET ALA GLU ARG ILE ALA TRP ALA PRO GLU GLY LYS ASP          
SEQRES   4 1  548  ARG PHE THR ILE SER HIS MET TYR ALA ASP ILE LYS CYS          
SEQRES   5 1  548  GLN LYS ILE SER PRO GLU GLY LYS ALA LYS ILE GLN LEU          
SEQRES   6 1  548  GLN LEU VAL LEU HIS ALA GLY ASP THR THR ASN PHE HIS          
SEQRES   7 1  548  PHE SER ASN GLU SER THR ALA VAL LYS GLU ARG ASP ALA          
SEQRES   8 1  548  VAL LYS ASP LEU LEU GLN GLN LEU LEU PRO LYS PHE LYS          
SEQRES   9 1  548  ARG LYS ALA ASN LYS GLU LEU GLU GLU LYS ASN ARG MET          
SEQRES  10 1  548  LEU GLN GLU ASP PRO VAL LEU PHE GLN LEU TYR LYS ASP          
SEQRES  11 1  548  LEU VAL VAL SER GLN VAL ILE SER ALA GLU GLU PHE TRP          
SEQRES  12 1  548  ALA ASN ARG LEU ASN VAL ASN ALA THR ASP SER SER SER          
SEQRES  13 1  548  THR SER ASN HIS LYS GLN ASP VAL GLY ILE SER ALA ALA          
SEQRES  14 1  548  PHE LEU ALA ASP VAL ARG PRO GLN THR ASP GLY CYS ASN          
SEQRES  15 1  548  GLY LEU ARG TYR ASN LEU THR SER ASP ILE ILE GLU SER          
SEQRES  16 1  548  ILE PHE ARG THR TYR PRO ALA VAL LYS MET LYS TYR ALA          
SEQRES  17 1  548  GLU ASN VAL PRO HIS ASN MET THR GLU LYS GLU PHE TRP          
SEQRES  18 1  548  THR ARG PHE PHE GLN SER HIS TYR PHE HIS ARG ASP ARG          
SEQRES  19 1  548  LEU ASN THR GLY SER LYS ASP LEU PHE ALA GLU CYS ALA          
SEQRES  20 1  548  LYS ILE ASP GLU LYS GLY LEU LYS THR MET VAL SER LEU          
SEQRES  21 1  548  GLY VAL LYS ASN PRO LEU LEU ASP LEU THR ALA LEU GLU          
SEQRES  22 1  548  ASP LYS PRO LEU ASP GLU GLY TYR GLY ILE SER SER VAL          
SEQRES  23 1  548  PRO SER ALA SER ASN SER LYS SER ILE LYS GLU ASN SER          
SEQRES  24 1  548  ASN ALA ALA ILE ILE LYS ARG PHE ASN HIS HIS SER ALA          
SEQRES  25 1  548  MET VAL LEU ALA ALA GLY LEU ARG LYS GLN GLU ALA GLN          
SEQRES  26 1  548  ASN GLU GLN THR SER GLU PRO SER ASN MET ASP GLY ASN          
SEQRES  27 1  548  SER GLY ASP ALA ASP CYS PHE GLN PRO ALA VAL LYS ARG          
SEQRES  28 1  548  ALA LYS LEU GLN GLU SER ILE GLU TYR GLU ASP LEU GLY          
SEQRES  29 1  548  LYS ASN ASN SER VAL LYS THR ILE ALA LEU ASN LEU LYS          
SEQRES  30 1  548  LYS SER ASP ARG TYR TYR HIS GLY PRO THR PRO ILE GLN          
SEQRES  31 1  548  SER LEU GLN TYR ALA THR SER GLN ASP ILE ILE ASN SER          
SEQRES  32 1  548  PHE GLN SER ILE ARG GLN GLU MET GLU ALA TYR THR PRO          
SEQRES  33 1  548  LYS LEU THR GLN VAL LEU SER SER SER ALA ALA SER SER          
SEQRES  34 1  548  THR ILE THR ALA LEU SER PRO GLY GLY ALA LEU MET GLN          
SEQRES  35 1  548  GLY GLY THR GLN GLN ALA ILE ASN GLN MET VAL PRO ASN          
SEQRES  36 1  548  ASP ILE GLN SER GLU LEU LYS HIS LEU TYR VAL ALA VAL          
SEQRES  37 1  548  GLY GLU LEU LEU ARG HIS PHE TRP SER CYS PHE PRO VAL          
SEQRES  38 1  548  ASN THR PRO PHE LEU GLU GLU LYS VAL VAL LYS MET LYS          
SEQRES  39 1  548  SER ASN LEU GLU ARG PHE GLN VAL THR LYS LEU CYS PRO          
SEQRES  40 1  548  PHE GLN GLU LYS ILE ARG ARG GLN TYR LEU SER THR ASN          
SEQRES  41 1  548  LEU VAL SER HIS ILE GLU GLU MET LEU GLN THR ALA TYR          
SEQRES  42 1  548  ASN LYS LEU HIS THR TRP GLN SER ARG ARG LEU MET LYS          
SEQRES  43 1  548  LYS THR                                                      
SEQRES   1 2  462  MET GLU SER THR PRO SER ARG GLY LEU ASN ARG VAL HIS          
SEQRES   2 2  462  LEU GLN CYS ARG ASN LEU GLN GLU PHE LEU GLY GLY LEU          
SEQRES   3 2  462  SER PRO GLY VAL LEU ASP ARG LEU TYR GLY HIS PRO ALA          
SEQRES   4 2  462  THR CYS LEU ALA VAL PHE ARG GLU LEU PRO SER LEU ALA          
SEQRES   5 2  462  LYS ASN TRP VAL MET ARG MET LEU PHE LEU GLU GLN PRO          
SEQRES   6 2  462  LEU PRO GLN ALA ALA VAL ALA LEU TRP VAL LYS LYS GLU          
SEQRES   7 2  462  PHE SER LYS ALA GLN GLU GLU SER THR GLY LEU LEU SER          
SEQRES   8 2  462  GLY LEU ARG ILE TRP HIS THR GLN LEU LEU PRO GLY GLY          
SEQRES   9 2  462  LEU GLN GLY LEU ILE LEU ASN PRO ILE PHE ARG GLN ASN          
SEQRES  10 2  462  LEU ARG ILE ALA LEU LEU GLY GLY GLY LYS ALA TRP SER          
SEQRES  11 2  462  ASP ASP THR SER GLN LEU GLY PRO ASP LYS HIS ALA ARG          
SEQRES  12 2  462  ASP VAL PRO SER LEU ASP LYS TYR ALA GLU GLU ARG TRP          
SEQRES  13 2  462  GLU VAL VAL LEU HIS PHE MET VAL GLY SER PRO SER ALA          
SEQRES  14 2  462  ALA VAL SER GLN ASP LEU ALA GLN LEU LEU SER GLN ALA          
SEQRES  15 2  462  GLY LEU MET LYS SER THR GLU PRO GLY GLU PRO PRO CYS          
SEQRES  16 2  462  ILE THR SER ALA GLY PHE GLN PHE LEU LEU LEU ASP THR          
SEQRES  17 2  462  PRO ALA GLN LEU TRP TYR PHE MET LEU GLN TYR LEU GLN          
SEQRES  18 2  462  THR ALA GLN SER ARG GLY MET ASP LEU VAL GLU ILE LEU          
SEQRES  19 2  462  SER PHE LEU PHE GLN LEU SER PHE SER THR LEU GLY LYS          
SEQRES  20 2  462  ASP TYR SER VAL GLU GLY MET SER ASP SER LEU LEU ASN          
SEQRES  21 2  462  PHE LEU GLN HIS LEU ARG GLU PHE GLY LEU VAL PHE GLN          
SEQRES  22 2  462  ARG LYS ARG LYS SER ARG ARG TYR TYR PRO THR ARG LEU          
SEQRES  23 2  462  ALA ILE ASN LEU SER SER GLY VAL SER GLY ALA GLY GLY          
SEQRES  24 2  462  THR VAL HIS GLN PRO GLY PHE ILE VAL VAL GLU THR ASN          
SEQRES  25 2  462  TYR ARG LEU TYR ALA TYR THR GLU SER GLU LEU GLN ILE          
SEQRES  26 2  462  ALA LEU ILE ALA LEU PHE SER GLU MET LEU TYR ARG PHE          
SEQRES  27 2  462  PRO ASN MET VAL VAL ALA GLN VAL THR ARG GLU SER VAL          
SEQRES  28 2  462  GLN GLN ALA ILE ALA SER GLY ILE THR ALA GLN GLN ILE          
SEQRES  29 2  462  ILE HIS PHE LEU ARG THR ARG ALA HIS PRO VAL MET LEU          
SEQRES  30 2  462  LYS GLN THR PRO VAL LEU PRO PRO THR ILE THR ASP GLN          
SEQRES  31 2  462  ILE ARG LEU TRP GLU LEU GLU ARG ASP ARG LEU ARG PHE          
SEQRES  32 2  462  THR GLU GLY VAL LEU TYR ASN GLN PHE LEU SER GLN VAL          
SEQRES  33 2  462  ASP PHE GLU LEU LEU LEU ALA HIS ALA ARG GLU LEU GLY          
SEQRES  34 2  462  VAL LEU VAL PHE GLU ASN SER ALA LYS ARG LEU MET VAL          
SEQRES  35 2  462  VAL THR PRO ALA GLY HIS SER ASP VAL LYS ARG PHE TRP          
SEQRES  36 2  462  LYS ARG GLN LYS HIS SER SER                                  
SEQRES   1 3  309  MET ASP ASP GLN GLY CYS PRO ARG CYS LYS THR THR LYS          
SEQRES   2 3  309  TYR ARG ASN PRO SER LEU LYS LEU MET VAL ASN VAL CYS          
SEQRES   3 3  309  GLY HIS THR LEU CYS GLU SER CYS VAL ASP LEU LEU PHE          
SEQRES   4 3  309  VAL ARG GLY ALA GLY ASN CYS PRO GLU CYS GLY THR PRO          
SEQRES   5 3  309  LEU ARG LYS SER ASN PHE ARG VAL GLN LEU PHE GLU ASP          
SEQRES   6 3  309  PRO THR VAL ASP LYS GLU VAL GLU ILE ARG LYS LYS VAL          
SEQRES   7 3  309  LEU LYS ILE TYR ASN LYS ARG GLU GLU ASP PHE PRO SER          
SEQRES   8 3  309  LEU ARG GLU TYR ASN ASP PHE LEU GLU GLU VAL GLU GLU          
SEQRES   9 3  309  ILE VAL PHE ASN LEU THR ASN ASN VAL ASP LEU ASP ASN          
SEQRES  10 3  309  THR LYS LYS LYS MET GLU ILE TYR GLN LYS GLU ASN LYS          
SEQRES  11 3  309  ASP VAL ILE GLN LYS ASN LYS LEU LYS LEU THR ARG GLU          
SEQRES  12 3  309  GLN GLU GLU LEU GLU GLU ALA LEU GLU VAL GLU ARG GLN          
SEQRES  13 3  309  GLU ASN GLU GLN ARG ARG LEU PHE ILE GLN LYS GLU GLU          
SEQRES  14 3  309  GLN LEU GLN GLN ILE LEU LYS ARG LYS ASN LYS GLN ALA          
SEQRES  15 3  309  PHE LEU ASP GLU LEU GLU SER SER ASP LEU PRO VAL ALA          
SEQRES  16 3  309  LEU LEU LEU ALA GLN HIS LYS ASP ARG SER THR GLN LEU          
SEQRES  17 3  309  GLU MET GLN LEU GLU LYS PRO LYS PRO VAL LYS PRO VAL          
SEQRES  18 3  309  THR PHE SER THR GLY ILE LYS MET GLY GLN HIS ILE SER          
SEQRES  19 3  309  LEU ALA PRO ILE HIS LYS LEU GLU GLU ALA LEU TYR GLU          
SEQRES  20 3  309  TYR GLN PRO LEU GLN ILE GLU THR TYR GLY PRO HIS VAL          
SEQRES  21 3  309  PRO GLU LEU GLU MET LEU GLY ARG LEU GLY TYR LEU ASN          
SEQRES  22 3  309  HIS VAL ARG ALA ALA SER PRO GLN ASP LEU ALA GLY GLY          
SEQRES  23 3  309  TYR THR SER SER LEU ALA CYS HIS ARG ALA LEU GLN ASP          
SEQRES  24 3  309  ALA PHE SER GLY LEU PHE TRP GLN PRO SER                      
SEQRES   1 4  308  MET VAL SER ASP GLU ASP GLU LEU ASN LEU LEU VAL ILE          
SEQRES   2 4  308  VAL VAL ASP ALA ASN PRO ILE TRP TRP GLY LYS GLN ALA          
SEQRES   3 4  308  LEU LYS GLU SER GLN PHE THR LEU SER LYS CYS ILE ASP          
SEQRES   4 4  308  ALA VAL MET VAL LEU GLY ASN SER HIS LEU PHE MET ASN          
SEQRES   5 4  308  ARG SER ASN LYS LEU ALA VAL ILE ALA SER HIS ILE GLN          
SEQRES   6 4  308  GLU SER ARG PHE LEU TYR PRO GLY LYS ASN GLY ARG LEU          
SEQRES   7 4  308  GLY ASP PHE PHE GLY ASP PRO GLY ASN PRO PRO GLU PHE          
SEQRES   8 4  308  ASN PRO SER GLY SER LYS ASP GLY LYS TYR GLU LEU LEU          
SEQRES   9 4  308  THR SER ALA ASN GLU VAL ILE VAL GLU GLU ILE LYS ASP          
SEQRES  10 4  308  LEU MET THR LYS SER ASP ILE LYS GLY GLN HIS THR GLU          
SEQRES  11 4  308  THR LEU LEU ALA GLY SER LEU ALA LYS ALA LEU CYS TYR          
SEQRES  12 4  308  ILE HIS ARG MET ASN LYS GLU VAL LYS ASP ASN GLN GLU          
SEQRES  13 4  308  MET LYS SER ARG ILE LEU VAL ILE LYS ALA ALA GLU ASP          
SEQRES  14 4  308  SER ALA LEU GLN TYR MET ASN PHE MET ASN VAL ILE PHE          
SEQRES  15 4  308  ALA ALA GLN LYS GLN ASN ILE LEU ILE ASP ALA CYS VAL          
SEQRES  16 4  308  LEU ASP SER ASP SER GLY LEU LEU GLN GLN ALA CYS ASP          
SEQRES  17 4  308  ILE THR GLY GLY LEU TYR LEU LYS VAL PRO GLN MET PRO          
SEQRES  18 4  308  SER LEU LEU GLN TYR LEU LEU TRP VAL PHE LEU PRO ASP          
SEQRES  19 4  308  GLN ASP GLN ARG SER GLN LEU ILE LEU PRO PRO PRO VAL          
SEQRES  20 4  308  HIS VAL ASP TYR ARG ALA ALA CYS PHE CYS HIS ARG ASN          
SEQRES  21 4  308  LEU ILE GLU ILE GLY TYR VAL CYS SER VAL CYS LEU SER          
SEQRES  22 4  308  ILE PHE CYS ASN PHE SER PRO ILE CYS THR THR CYS GLU          
SEQRES  23 4  308  THR ALA PHE LYS ILE SER LEU PRO PRO VAL LEU LYS ALA          
SEQRES  24 4  308  LYS LYS LYS LYS LEU LYS VAL SER ALA                          
SEQRES   1 5   71  MET VAL ASN VAL LEU LYS GLY VAL LEU ILE GLU CYS ASP          
SEQRES   2 5   71  PRO ALA MET LYS GLN PHE LEU LEU TYR LEU ASP GLU SER          
SEQRES   3 5   71  ASN ALA LEU GLY LYS LYS PHE ILE ILE GLN ASP ILE ASP          
SEQRES   4 5   71  ASP THR HIS VAL PHE VAL ILE ALA GLU LEU VAL ASN VAL          
SEQRES   5 5   71  LEU GLN GLU ARG VAL GLY GLU LEU MET ASP GLN ASN ALA          
SEQRES   6 5   71  PHE SER LEU THR GLN LYS                                      
SEQRES   1 6  395  MET ASP GLU GLU PRO GLU ARG THR LYS ARG TRP GLU GLY          
SEQRES   2 6  395  GLY TYR GLU ARG THR TRP GLU ILE LEU LYS GLU ASP GLU          
SEQRES   3 6  395  SER GLY SER LEU LYS ALA THR ILE GLU ASP ILE LEU PHE          
SEQRES   4 6  395  LYS ALA LYS ARG LYS ARG VAL PHE GLU HIS HIS GLY GLN          
SEQRES   5 6  395  VAL ARG LEU GLY MET MET ARG HIS LEU TYR VAL VAL VAL          
SEQRES   6 6  395  ASP GLY SER ARG THR MET GLU ASP GLN ASP LEU LYS PRO          
SEQRES   7 6  395  ASN ARG LEU THR CYS THR LEU LYS LEU LEU GLU TYR PHE          
SEQRES   8 6  395  VAL GLU GLU TYR PHE ASP GLN ASN PRO ILE SER GLN ILE          
SEQRES   9 6  395  GLY ILE ILE VAL THR LYS SER LYS ARG ALA GLU LYS LEU          
SEQRES  10 6  395  THR GLU LEU SER GLY ASN PRO ARG LYS HIS ILE THR SER          
SEQRES  11 6  395  LEU LYS LYS ALA VAL ASP MET THR CYS HIS GLY GLU PRO          
SEQRES  12 6  395  SER LEU TYR ASN SER LEU SER ILE ALA MET GLN THR LEU          
SEQRES  13 6  395  LYS HIS MET PRO GLY HIS THR SER ARG GLU VAL LEU ILE          
SEQRES  14 6  395  ILE PHE SER SER LEU THR THR CYS ASP PRO SER ASN ILE          
SEQRES  15 6  395  TYR ASP LEU ILE LYS THR LEU LYS ALA ALA LYS ILE ARG          
SEQRES  16 6  395  VAL SER VAL ILE GLY LEU SER ALA GLU VAL ARG VAL CYS          
SEQRES  17 6  395  THR VAL LEU ALA ARG GLU THR GLY GLY THR TYR HIS VAL          
SEQRES  18 6  395  ILE LEU ASP GLU SER HIS TYR LYS GLU LEU LEU THR HIS          
SEQRES  19 6  395  HIS VAL SER PRO PRO PRO ALA SER SER SER SER GLU CYS          
SEQRES  20 6  395  SER LEU ILE ARG MET GLY PHE PRO GLN HIS THR ILE ALA          
SEQRES  21 6  395  SER LEU SER ASP GLN ASP ALA LYS PRO SER PHE SER MET          
SEQRES  22 6  395  ALA HIS LEU ASP GLY ASN THR GLU PRO GLY LEU THR LEU          
SEQRES  23 6  395  GLY GLY TYR PHE CYS PRO GLN CYS ARG ALA LYS TYR CYS          
SEQRES  24 6  395  GLU LEU PRO VAL GLU CYS LYS ILE CYS GLY LEU THR LEU          
SEQRES  25 6  395  VAL SER ALA PRO HIS LEU ALA ARG SER TYR HIS HIS LEU          
SEQRES  26 6  395  PHE PRO LEU ASP ALA PHE GLN GLU ILE PRO LEU GLU GLU          
SEQRES  27 6  395  TYR ASN GLY GLU ARG PHE CYS TYR GLY CYS GLN GLY GLU          
SEQRES  28 6  395  LEU LYS ASP GLN HIS VAL TYR VAL CYS ALA VAL CYS GLN          
SEQRES  29 6  395  ASN VAL PHE CYS VAL ASP CYS ASP VAL PHE VAL HIS ASP          
SEQRES  30 6  395  SER LEU HIS CYS CYS PRO GLY CYS ILE HIS LYS ILE PRO          
SEQRES  31 6  395  ALA PRO SER GLY VAL                                          
SEQRES   1 7  782  MET GLY LYS ARG ASP ARG ALA ASP ARG ASP LYS LYS LYS          
SEQRES   2 7  782  SER ARG LYS ARG HIS TYR GLU ASP GLU GLU ASP ASP GLU          
SEQRES   3 7  782  GLU ASP ALA PRO GLY ASN ASP PRO GLN GLU ALA VAL PRO          
SEQRES   4 7  782  SER ALA ALA GLY LYS GLN VAL ASP GLU SER GLY THR LYS          
SEQRES   5 7  782  VAL ASP GLU TYR GLY ALA LYS ASP TYR ARG LEU GLN MET          
SEQRES   6 7  782  PRO LEU LYS ASP ASP HIS THR SER ARG PRO LEU TRP VAL          
SEQRES   7 7  782  ALA PRO ASP GLY HIS ILE PHE LEU GLU ALA PHE SER PRO          
SEQRES   8 7  782  VAL TYR LYS TYR ALA GLN ASP PHE LEU VAL ALA ILE ALA          
SEQRES   9 7  782  GLU PRO VAL CYS ARG PRO THR HIS VAL HIS GLU TYR LYS          
SEQRES  10 7  782  LEU THR ALA TYR SER LEU TYR ALA ALA VAL SER VAL GLY          
SEQRES  11 7  782  LEU GLN THR SER ASP ILE THR GLU TYR LEU ARG LYS LEU          
SEQRES  12 7  782  SER LYS THR GLY VAL PRO ASP GLY ILE MET GLN PHE ILE          
SEQRES  13 7  782  LYS LEU CYS THR VAL SER TYR GLY LYS VAL LYS LEU VAL          
SEQRES  14 7  782  LEU LYS HIS ASN ARG TYR PHE VAL GLU SER CYS HIS PRO          
SEQRES  15 7  782  ASP VAL ILE GLN HIS LEU LEU GLN ASP PRO VAL ILE ARG          
SEQRES  16 7  782  GLU CYS ARG LEU ARG ASN SER GLU GLY GLU ALA THR GLU          
SEQRES  17 7  782  LEU ILE THR GLU THR PHE THR SER LYS SER ALA ILE SER          
SEQRES  18 7  782  LYS THR ALA GLU SER SER GLY GLY PRO SER THR SER ARG          
SEQRES  19 7  782  VAL THR ASP PRO GLN GLY LYS SER ASP ILE PRO MET ASP          
SEQRES  20 7  782  LEU PHE ASP PHE TYR GLU GLN MET ASP LYS ASP GLU GLU          
SEQRES  21 7  782  GLU GLU GLU GLU THR GLN THR VAL SER PHE GLU VAL LYS          
SEQRES  22 7  782  GLN GLU MET ILE GLU GLU LEU GLN LYS ARG CYS ILE HIS          
SEQRES  23 7  782  LEU GLU TYR PRO LEU LEU ALA GLU TYR ASP PHE ARG ASN          
SEQRES  24 7  782  ASP SER VAL ASN PRO ASP ILE ASN ILE ASP LEU LYS PRO          
SEQRES  25 7  782  THR ALA VAL LEU ARG PRO TYR GLN GLU LYS SER LEU ARG          
SEQRES  26 7  782  LYS MET PHE GLY ASN GLY ARG ALA ARG SER GLY VAL ILE          
SEQRES  27 7  782  VAL LEU PRO CYS GLY ALA GLY LYS SER LEU VAL GLY VAL          
SEQRES  28 7  782  THR ALA ALA CYS THR VAL ARG LYS ARG CYS LEU VAL LEU          
SEQRES  29 7  782  GLY ASN SER ALA VAL SER VAL GLU GLN TRP LYS ALA GLN          
SEQRES  30 7  782  PHE LYS MET TRP SER THR ILE ASP ASP SER GLN ILE CYS          
SEQRES  31 7  782  ARG PHE THR SER ASP ALA LYS ASP LYS PRO ILE GLY CYS          
SEQRES  32 7  782  SER VAL ALA ILE SER THR TYR SER MET LEU GLY HIS THR          
SEQRES  33 7  782  THR LYS ARG SER TRP GLU ALA GLU ARG VAL MET GLU TRP          
SEQRES  34 7  782  LEU LYS THR GLN GLU TRP GLY LEU MET ILE LEU ASP GLU          
SEQRES  35 7  782  VAL HIS THR ILE PRO ALA LYS MET PHE ARG ARG VAL LEU          
SEQRES  36 7  782  THR ILE VAL GLN ALA HIS CYS LYS LEU GLY LEU THR ALA          
SEQRES  37 7  782  THR LEU VAL ARG GLU ASP ASP LYS ILE VAL ASP LEU ASN          
SEQRES  38 7  782  PHE LEU ILE GLY PRO LYS LEU TYR GLU ALA ASN TRP MET          
SEQRES  39 7  782  GLU LEU GLN ASN ASN GLY TYR ILE ALA LYS VAL GLN CYS          
SEQRES  40 7  782  ALA GLU VAL TRP CYS PRO MET SER PRO GLU PHE TYR ARG          
SEQRES  41 7  782  GLU TYR VAL ALA ILE LYS THR LYS LYS ARG ILE LEU LEU          
SEQRES  42 7  782  TYR THR MET ASN PRO ASN LYS PHE ARG ALA CYS GLN PHE          
SEQRES  43 7  782  LEU ILE LYS PHE HIS GLU ARG ARG ASN ASP LYS ILE ILE          
SEQRES  44 7  782  VAL PHE ALA ASP ASN VAL PHE ALA LEU LYS GLU TYR ALA          
SEQRES  45 7  782  ILE ARG LEU ASN LYS PRO TYR ILE TYR GLY PRO THR SER          
SEQRES  46 7  782  GLN GLY GLU ARG MET GLN ILE LEU GLN ASN PHE LYS HIS          
SEQRES  47 7  782  ASN PRO LYS ILE ASN THR ILE PHE ILE SER LYS VAL GLY          
SEQRES  48 7  782  ASP THR SER PHE ASP LEU PRO GLU ALA ASN VAL LEU ILE          
SEQRES  49 7  782  GLN ILE SER SER HIS GLY GLY SER ARG ARG GLN GLU ALA          
SEQRES  50 7  782  GLN ARG LEU GLY ARG VAL LEU ARG ALA LYS LYS GLY MET          
SEQRES  51 7  782  VAL ALA GLU GLU TYR ASN ALA PHE PHE TYR SER LEU VAL          
SEQRES  52 7  782  SER GLN ASP THR GLN GLU MET ALA TYR SER THR LYS ARG          
SEQRES  53 7  782  GLN ARG PHE LEU VAL ASP GLN GLY TYR SER PHE LYS VAL          
SEQRES  54 7  782  ILE THR LYS LEU ALA GLY MET GLU GLU GLU ASP LEU ALA          
SEQRES  55 7  782  PHE SER THR LYS GLU GLU GLN GLN GLN LEU LEU GLN LYS          
SEQRES  56 7  782  VAL LEU ALA ALA THR ASP LEU ASP ALA GLU GLU GLU VAL          
SEQRES  57 7  782  VAL ALA GLY GLU PHE GLY SER ARG SER SER GLN ALA SER          
SEQRES  58 7  782  ARG ARG PHE GLY THR MET SER SER MET SER GLY ALA ASP          
SEQRES  59 7  782  ASP THR VAL TYR MET GLU TYR HIS SER SER ARG SER LYS          
SEQRES  60 7  782  ALA PRO SER LYS HIS VAL HIS PRO LEU PHE LYS ARG PHE          
SEQRES  61 7  782  ARG LYS                                                      
SEQRES   1 8  346  MET ALA LEU ASP VAL LYS SER ARG ALA LYS ARG TYR GLU          
SEQRES   2 8  346  LYS LEU ASP PHE LEU GLY GLU GLY GLN PHE ALA THR VAL          
SEQRES   3 8  346  TYR LYS ALA ARG ASP LYS ASN THR ASN GLN ILE VAL ALA          
SEQRES   4 8  346  ILE LYS LYS ILE LYS LEU GLY HIS ARG SER GLU ALA LYS          
SEQRES   5 8  346  ASP GLY ILE ASN ARG THR ALA LEU ARG GLU ILE LYS LEU          
SEQRES   6 8  346  LEU GLN GLU LEU SER HIS PRO ASN ILE ILE GLY LEU LEU          
SEQRES   7 8  346  ASP ALA PHE GLY HIS LYS SER ASN ILE SER LEU VAL PHE          
SEQRES   8 8  346  ASP PHE MET GLU THR ASP LEU GLU VAL ILE ILE LYS ASP          
SEQRES   9 8  346  ASN SER LEU VAL LEU THR PRO SER HIS ILE LYS ALA TYR          
SEQRES  10 8  346  MET LEU MET THR LEU GLN GLY LEU GLU TYR LEU HIS GLN          
SEQRES  11 8  346  HIS TRP ILE LEU HIS ARG ASP LEU LYS PRO ASN ASN LEU          
SEQRES  12 8  346  LEU LEU ASP GLU ASN GLY VAL LEU LYS LEU ALA ASP PHE          
SEQRES  13 8  346  GLY LEU ALA LYS SER PHE GLY SER PRO ASN ARG ALA TYR          
SEQRES  14 8  346  THR HIS GLN VAL VAL THR ARG TRP TYR ARG ALA PRO GLU          
SEQRES  15 8  346  LEU LEU PHE GLY ALA ARG MET TYR GLY VAL GLY VAL ASP          
SEQRES  16 8  346  MET TRP ALA VAL GLY CYS ILE LEU ALA GLU LEU LEU LEU          
SEQRES  17 8  346  ARG VAL PRO PHE LEU PRO GLY ASP SER ASP LEU ASP GLN          
SEQRES  18 8  346  LEU THR ARG ILE PHE GLU THR LEU GLY THR PRO THR GLU          
SEQRES  19 8  346  GLU GLN TRP PRO ASP MET CYS SER LEU PRO ASP TYR VAL          
SEQRES  20 8  346  THR PHE LYS SER PHE PRO GLY ILE PRO LEU HIS HIS ILE          
SEQRES  21 8  346  PHE SER ALA ALA GLY ASP ASP LEU LEU ASP LEU ILE GLN          
SEQRES  22 8  346  GLY LEU PHE LEU PHE ASN PRO CYS ALA ARG ILE THR ALA          
SEQRES  23 8  346  THR GLN ALA LEU LYS MET LYS TYR PHE SER ASN ARG PRO          
SEQRES  24 8  346  GLY PRO THR PRO GLY CYS GLN LEU PRO ARG PRO ASN CYS          
SEQRES  25 8  346  PRO VAL GLU THR LEU LYS GLU GLN SER ASN PRO ALA LEU          
SEQRES  26 8  346  ALA ILE LYS ARG LYS ARG THR GLU ALA LEU GLU GLN GLY          
SEQRES  27 8  346  GLY LEU PRO LYS LYS LEU ILE PHE                              
SEQRES   1 9  323  MET TYR HIS ASN SER SER GLN LYS ARG HIS TRP THR PHE          
SEQRES   2 9  323  SER SER GLU GLU GLN LEU ALA ARG LEU ARG ALA ASP ALA          
SEQRES   3 9  323  ASN ARG LYS PHE ARG CYS LYS ALA VAL ALA ASN GLY LYS          
SEQRES   4 9  323  VAL LEU PRO ASN ASP PRO VAL PHE LEU GLU PRO HIS GLU          
SEQRES   5 9  323  GLU MET THR LEU CYS LYS TYR TYR GLU LYS ARG LEU LEU          
SEQRES   6 9  323  GLU PHE CYS SER VAL PHE LYS PRO ALA MET PRO ARG SER          
SEQRES   7 9  323  VAL VAL GLY THR ALA CYS MET TYR PHE LYS ARG PHE TYR          
SEQRES   8 9  323  LEU ASN ASN SER VAL MET GLU TYR HIS PRO ARG ILE ILE          
SEQRES   9 9  323  MET LEU THR CYS ALA PHE LEU ALA CYS LYS VAL ASP GLU          
SEQRES  10 9  323  PHE ASN VAL SER SER PRO GLN PHE VAL GLY ASN LEU ARG          
SEQRES  11 9  323  GLU SER PRO LEU GLY GLN GLU LYS ALA LEU GLU GLN ILE          
SEQRES  12 9  323  LEU GLU TYR GLU LEU LEU LEU ILE GLN GLN LEU ASN PHE          
SEQRES  13 9  323  HIS LEU ILE VAL HIS ASN PRO TYR ARG PRO PHE GLU GLY          
SEQRES  14 9  323  PHE LEU ILE ASP LEU LYS THR ARG TYR PRO ILE LEU GLU          
SEQRES  15 9  323  ASN PRO GLU ILE LEU ARG LYS THR ALA ASP ASP PHE LEU          
SEQRES  16 9  323  ASN ARG ILE ALA LEU THR ASP ALA TYR LEU LEU TYR THR          
SEQRES  17 9  323  PRO SER GLN ILE ALA LEU THR ALA ILE LEU SER SER ALA          
SEQRES  18 9  323  SER ARG ALA GLY ILE THR MET GLU SER TYR LEU SER GLU          
SEQRES  19 9  323  SER LEU MET LEU LYS GLU ASN ARG THR CYS LEU SER GLN          
SEQRES  20 9  323  LEU LEU ASP ILE MET LYS SER MET ARG ASN LEU VAL LYS          
SEQRES  21 9  323  LYS TYR GLU PRO PRO ARG SER GLU GLU VAL ALA VAL LEU          
SEQRES  22 9  323  LYS GLN LYS LEU GLU ARG CYS HIS SER ALA GLU LEU ALA          
SEQRES  23 9  323  LEU ASN VAL ILE THR LYS LYS ARG LYS GLY TYR GLU ASP          
SEQRES  24 9  323  ASP ASP TYR VAL SER LYS LYS SER LYS HIS GLU GLU GLU          
SEQRES  25 9  323  GLU TRP THR ASP ASP ASP LEU VAL GLU SER LEU                  
SEQRES   1 X   65   DG  DA  DA  DG  DG  DG  DC  DG  DC  DC  DT  DA  DT          
SEQRES   2 X   65   DA  DA  DA  DA  DG  DG  DG  DG  DG  DT  DG  DG  DG          
SEQRES   3 X   65   DG  DG  DC  DG  DC  DG  DT  DT  DC  DG  DT  DC  DC          
SEQRES   4 X   65   DT  DC  DA  DG  DT  DC  DG  DC  DG  DA  DT  DC  DG          
SEQRES   5 X   65   DA  DA  DC  DA  DC  DT  DC  DG  DA  DG  DC  DC  DG          
SEQRES   1 Y   65   DC  DG  DG  DC  DT  DC  DG  DA  DG  DT  DG  DT  DT          
SEQRES   2 Y   65   DC  DG  DA  DT  DC  DG  DC  DG  DA  DC  DT  DG  DA          
SEQRES   3 Y   65   DG  DG  DA  DC  DG  DA  DA  DC  DG  DC  DG  DC  DC          
SEQRES   4 Y   65   DC  DC  DC  DA  DC  DC  DC  DC  DC  DT  DT  DT  DT          
SEQRES   5 Y   65   DA  DT  DA  DG  DG  DC  DG  DC  DC  DC  DT  DT  DC          
HET     MG  A2001       1                                                       
HET     ZN  A2002       1                                                       
HET     ZN  A2003       1                                                       
HET     MG  B1201       1                                                       
HET     ZN  B1202       1                                                       
HET     ZN  C 301       1                                                       
HET     ZN  I 201       1                                                       
HET     ZN  I 202       1                                                       
HET     ZN  J 101       1                                                       
HET     ZN  L 101       1                                                       
HET     ZN  M 401       1                                                       
HET     ZN  Q 501       1                                                       
HET     ZN  U 401       1                                                       
HET    SF4  01000       8                                                       
HET     ZN  3 401       1                                                       
HET     ZN  3 402       1                                                       
HET     ZN  4 401       1                                                       
HET     ZN  6 401       1                                                       
HET     ZN  6 402       1                                                       
HET     ZN  6 403       1                                                       
HETNAM      MG MAGNESIUM ION                                                    
HETNAM      ZN ZINC ION                                                         
HETNAM     SF4 IRON/SULFUR CLUSTER                                              
FORMUL  34   MG    2(MG 2+)                                                     
FORMUL  35   ZN    17(ZN 2+)                                                    
FORMUL  47  SF4    FE4 S4                                                       
HELIX    1 AA1 SER A   27  ARG A   33  1                                   7    
HELIX    2 AA2 PHE A   99  VAL A  110  1                                  12    
HELIX    3 AA3 ILE A  126  LYS A  132  1                                   7    
HELIX    4 AA4 GLN A  136  LYS A  151  1                                  16    
HELIX    5 AA5 SER A  217  ILE A  228  1                                  12    
HELIX    6 AA6 SER A  229  GLY A  237  1                                   9    
HELIX    7 AA7 ARG A  244  MET A  248  5                                   5    
HELIX    8 AA8 ASP A  274  ASN A  296  1                                  23    
HELIX    9 AA9 ALA A  300  MET A  317  1                                  18    
HELIX   10 AB1 LYS A  340  GLY A  345  1                                   6    
HELIX   11 AB2 PRO A  381  ALA A  386  1                                   6    
HELIX   12 AB3 THR A  395  PHE A  397  5                                   3    
HELIX   13 AB4 ASN A  398  GLY A  409  1                                  12    
HELIX   14 AB5 ASN A  485  ASN A  493  1                                   9    
HELIX   15 AB6 SER A  508  GLU A  517  1                                  10    
HELIX   16 AB7 GLN A  539  THR A  549  1                                  11    
HELIX   17 AB8 GLU A  559  PHE A  566  1                                   8    
HELIX   18 AB9 ILE A  591  ILE A  595  5                                   5    
HELIX   19 AC1 VAL A  653  LEU A  658  1                                   6    
HELIX   20 AC2 ILE A  664  GLY A  684  1                                  21    
HELIX   21 AC3 ILE A  689  ILE A  693  5                                   5    
HELIX   22 AC4 ASP A  695  ASN A  722  1                                  28    
HELIX   23 AC5 LEU A  733  LEU A  760  1                                  28    
HELIX   24 AC6 ASN A  764  GLY A  773  1                                  10    
HELIX   25 AC7 LYS A  778  GLN A  783  1                                   6    
HELIX   26 AC8 GLY A  816  ARG A  820  5                                   5    
HELIX   27 AC9 THR A  832  LYS A  866  1                                  35    
HELIX   28 AD1 ARG A  890  ASP A  894  5                                   5    
HELIX   29 AD2 SER A  912  ARG A  921  1                                  10    
HELIX   30 AD3 LEU A  938  VAL A  942  5                                   5    
HELIX   31 AD4 ASN A  945  VAL A  965  1                                  21    
HELIX   32 AD5 VAL A  965  PHE A  970  1                                   6    
HELIX   33 AD6 ASN A  982  PHE A  994  1                                  13    
HELIX   34 AD7 HIS A 1005  LYS A 1019  1                                  15    
HELIX   35 AD8 ASP A 1027  ASN A 1036  1                                  10    
HELIX   36 AD9 THR A 1038  LEU A 1049  1                                  12    
HELIX   37 AE1 SER A 1061  ALA A 1079  1                                  19    
HELIX   38 AE2 MET A 1086  THR A 1100  1                                  15    
HELIX   39 AE3 GLY A 1120  ILE A 1130  1                                  11    
HELIX   40 AE4 LEU A 1144  ARG A 1149  5                                   6    
HELIX   41 AE5 ALA A 1151  GLU A 1162  1                                  12    
HELIX   42 AE6 THR A 1165  VAL A 1169  1                                   5    
HELIX   43 AE7 GLU A 1191  TYR A 1196  1                                   6    
HELIX   44 AE8 ASP A 1217  LYS A 1225  1                                   9    
HELIX   45 AE9 MET A 1228  ASN A 1236  1                                   9    
HELIX   46 AF1 ASP A 1280  LEU A 1293  1                                  14    
HELIX   47 AF2 ILE A 1301  SER A 1305  5                                   5    
HELIX   48 AF3 SER A 1342  SER A 1348  1                                   7    
HELIX   49 AF4 ILE A 1362  LEU A 1369  1                                   8    
HELIX   50 AF5 GLY A 1370  GLY A 1390  1                                  21    
HELIX   51 AF6 ASN A 1394  THR A 1406  1                                  13    
HELIX   52 AF7 THR A 1415  VAL A 1419  5                                   5    
HELIX   53 AF8 GLY A 1425  CYS A 1430  1                                   6    
HELIX   54 AF9 THR A 1435  GLY A 1446  1                                  12    
HELIX   55 AG1 ASP A 1476  MET A 1484  1                                   9    
HELIX   56 AG2 TRP B   22  GLU B   24  5                                   3    
HELIX   57 AG3 ALA B   25  LYS B   37  1                                  13    
HELIX   58 AG4 VAL B   40  GLU B   49  1                                  10    
HELIX   59 AG5 MET B   53  ASP B   61  1                                   9    
HELIX   60 AG6 ASN B  111  ARG B  116  1                                   6    
HELIX   61 AG7 THR B  167  CYS B  172  1                                   6    
HELIX   62 AG8 ALA B  251  ARG B  255  5                                   5    
HELIX   63 AG9 ILE B  269  LEU B  276  1                                   8    
HELIX   64 AH1 SER B  280  ILE B  289  1                                  10    
HELIX   65 AH2 ASP B  294  GLU B  296  5                                   3    
HELIX   66 AH3 MET B  297  LYS B  302  1                                   6    
HELIX   67 AH4 PRO B  303  PHE B  309  5                                   7    
HELIX   68 AH5 GLU B  313  ARG B  324  1                                  12    
HELIX   69 AH6 GLU B  333  LYS B  345  1                                  13    
HELIX   70 AH7 SER B  354  PHE B  356  5                                   3    
HELIX   71 AH8 CYS B  357  ALA B  376  1                                  20    
HELIX   72 AH9 HIS B  387  GLY B  389  5                                   3    
HELIX   73 AI1 GLY B  397  GLY B  426  1                                  30    
HELIX   74 AI2 ASN B  430  ILE B  435  1                                   6    
HELIX   75 AI3 ARG B  438  SER B  447  1                                  10    
HELIX   76 AI4 THR B  474  ARG B  483  1                                  10    
HELIX   77 AI5 HIS B  502  TRP B  506  5                                   5    
HELIX   78 AI6 PRO B  538  TRP B  548  1                                  11    
HELIX   79 AI7 SER B  557  ILE B  561  5                                   5    
HELIX   80 AI8 ASP B  579  ARG B  592  1                                  14    
HELIX   81 AI9 LYS B  637  GLU B  645  1                                   9    
HELIX   82 AJ1 ARG B  646  TYR B  648  5                                   3    
HELIX   83 AJ2 SER B  652  ALA B  658  1                                   7    
HELIX   84 AJ3 ASP B  666  THR B  672  1                                   7    
HELIX   85 AJ4 HIS B  699  LEU B  704  5                                   6    
HELIX   86 AJ5 GLN B  718  GLN B  731  1                                  14    
HELIX   87 AJ6 THR B  761  TYR B  766  5                                   6    
HELIX   88 AJ7 ARG B  798  PHE B  805  1                                   8    
HELIX   89 AJ8 ASN B  968  ILE B  972  5                                   5    
HELIX   90 AJ9 ILE B  978  GLY B  994  1                                  17    
HELIX   91 AK1 GLN B 1009  GLY B 1019  1                                  11    
HELIX   92 AK2 GLY B 1087  GLY B 1098  1                                  12    
HELIX   93 AK3 ALA B 1099  ARG B 1106  1                                   8    
HELIX   94 AK4 PRO B 1152  MET B 1163  1                                  12    
HELIX   95 AK5 SER B 1164  SER B 1166  5                                   3    
HELIX   96 AK6 ASP C   27  PHE C   38  1                                  12    
HELIX   97 AK7 HIS C   60  LEU C   70  1                                  11    
HELIX   98 AK8 HIS C  173  ASN C  177  5                                   5    
HELIX   99 AK9 ARG C  240  ASP C  270  1                                  31    
HELIX  100 AL1 LEU D   33  SER D   50  1                                  18    
HELIX  101 AL2 SER D   58  PHE D   71  1                                  14    
HELIX  102 AL3 ASN D   76  LEU D   87  1                                  12    
HELIX  103 AL4 HIS D   93  LEU D  100  1                                   8    
HELIX  104 AL5 THR D  107  ILE D  115  1                                   9    
HELIX  105 AL6 PRO D  116  GLU D  119  5                                   4    
HELIX  106 AL7 GLU D  123  ARG D  138  1                                  16    
HELIX  107 AL8 GLU E    5  GLY E   25  1                                  21    
HELIX  108 AL9 THR E   29  ASP E   34  1                                   6    
HELIX  109 AM1 THR E   36  LYS E   41  1                                   6    
HELIX  110 AM2 GLY E   83  ASN E   98  1                                  16    
HELIX  111 AM3 THR E  111  ASP E  120  1                                  10    
HELIX  112 AM4 GLN E  132  LEU E  136  1                                   5    
HELIX  113 AM5 ASN E  138  HIS E  142  5                                   5    
HELIX  114 AM6 THR E  152  ALA E  161  1                                  10    
HELIX  115 AM7 ASP E  177  GLY E  184  1                                   8    
HELIX  116 AM8 THR F   58  MET F   75  1                                  18    
HELIX  117 AM9 ASP F   88  ALA F   99  1                                  12    
HELIX  118 AN1 ASN G   21  THR G   32  1                                  12    
HELIX  119 AN2 LYS J   17  GLU J   28  1                                  12    
HELIX  120 AN3 THR J   30  LEU J   38  1                                   9    
HELIX  121 AN4 ARG J   42  ALA J   51  1                                  10    
HELIX  122 AN5 LEU J   55  LEU J   60  1                                   6    
HELIX  123 AN6 ASP K   39  ASP K   53  1                                  15    
HELIX  124 AN7 SER K   82  ILE K  109  1                                  28    
HELIX  125 AN8 SER M  108  SER M  110  5                                   3    
HELIX  126 AN9 ASP M  111  ALA M  125  1                                  15    
HELIX  127 AO1 PRO M  131  LYS M  149  1                                  19    
HELIX  128 AO2 ALA M  155  GLY M  172  1                                  18    
HELIX  129 AO3 THR M  176  ALA M  182  1                                   7    
HELIX  130 AO4 SER M  187  GLU M  203  1                                  17    
HELIX  131 AO5 PRO M  225  ASP M  243  1                                  19    
HELIX  132 AO6 SER M  249  ALA M  264  1                                  16    
HELIX  133 AO7 THR M  270  GLY M  279  1                                  10    
HELIX  134 AO8 ALA M  281  ARG M  290  1                                  10    
HELIX  135 AO9 VAL N   10  ASN N   23  1                                  14    
HELIX  136 AP1 VAL N   25  GLY N   33  1                                   9    
HELIX  137 AP2 ASP N   35  MET N   51  1                                  17    
HELIX  138 AP3 LEU N  314  ASP N  318  5                                   5    
HELIX  139 AP4 TYR O    3  ASN O    8  5                                   6    
HELIX  140 AP5 THR O    9  SER O   25  1                                  17    
HELIX  141 AP6 GLN O   31  ALA O   47  1                                  17    
HELIX  142 AP7 ASP P  179  ALA P  187  1                                   9    
HELIX  143 AP8 SER P  226  GLY P  245  1                                  20    
HELIX  144 AP9 ARG P  269  HIS P  277  1                                   9    
HELIX  145 AQ1 VAL P  317  PHE P  325  1                                   9    
HELIX  146 AQ2 ILE P  328  GLY P  334  1                                   7    
HELIX  147 AQ3 PRO Q   11  PHE Q   25  1                                  15    
HELIX  148 AQ4 GLY Q   27  ASN Q   40  1                                  14    
HELIX  149 AQ5 GLU Q   46  LEU Q   51  1                                   6    
HELIX  150 AQ6 ASP Q   55  ASP Q   69  1                                  15    
HELIX  151 AQ7 THR Q   98  ASN Q  123  1                                  26    
HELIX  152 AQ8 THR Q  137  ALA Q  141  5                                   5    
HELIX  153 AQ9 ALA Q  173  GLN Q  183  1                                  11    
HELIX  154 AR1 GLN Q  183  ALA Q  200  1                                  18    
HELIX  155 AR2 HIS Q  220  GLY Q  232  1                                  13    
HELIX  156 AR3 LEU Q  264  ARG Q  266  5                                   3    
HELIX  157 AR4 ALA Q  267  SER Q  273  1                                   7    
HELIX  158 AR5 ASN Q  318  THR Q  332  1                                  15    
HELIX  159 AR6 TYR Q  405  GLN Q  410  1                                   6    
HELIX  160 AR7 ARG Q  411  VAL Q  415  5                                   5    
HELIX  161 AR8 THR Q  419  MET Q  429  1                                  11    
HELIX  162 AR9 ARG Q  432  LEU Q  437  1                                   6    
HELIX  163 AS1 GLY R   76  ARG R   88  1                                  13    
HELIX  164 AS2 LEU R   99  THR R  106  1                                   8    
HELIX  165 AS3 LEU R  113  LEU R  119  1                                   7    
HELIX  166 AS4 ALA R  150  GLY R  162  1                                  13    
HELIX  167 AS5 LEU R  168  LEU R  175  1                                   8    
HELIX  168 AS6 LYS R  180  GLY R  186  1                                   7    
HELIX  169 AS7 ASP R  213  VAL R  223  1                                  11    
HELIX  170 AS8 ASP R  229  GLY R  241  1                                  13    
HELIX  171 AS9 GLY S    5  GLN S    9  5                                   5    
HELIX  172 AT1 GLU S  161  LYS S  169  1                                   9    
HELIX  173 AT2 HIS S  173  GLN S  178  1                                   6    
HELIX  174 AT3 THR T   10  ASN T   15  1                                   6    
HELIX  175 AT4 PRO T   24  GLN T   29  1                                   6    
HELIX  176 AT5 GLN T   30  ALA T   34  5                                   5    
HELIX  177 AT6 ASP T   61  ILE T   65  5                                   5    
HELIX  178 AT7 ARG T  126  SER T  136  1                                  11    
HELIX  179 AT8 ASN T  158  LYS T  169  1                                  12    
HELIX  180 AT9 GLN T  181  MET T  186  1                                   6    
HELIX  181 AU1 LEU T  199  THR T  206  1                                   8    
HELIX  182 AU2 PRO T  209  ILE T  220  1                                  12    
HELIX  183 AU3 ASP U  138  THR U  154  1                                  17    
HELIX  184 AU4 ASP U  157  GLY U  162  1                                   6    
HELIX  185 AU5 ASP U  164  ARG U  181  1                                  18    
HELIX  186 AU6 ASP U  184  LYS U  199  1                                  16    
HELIX  187 AU7 ASN U  203  CYS U  212  1                                  10    
HELIX  188 AU8 ASP U  218  ARG U  222  5                                   5    
HELIX  189 AU9 LEU U  233  ILE U  245  1                                  13    
HELIX  190 AV1 ARG U  246  MET U  250  5                                   5    
HELIX  191 AV2 GLU 0   20  LYS 0   35  1                                  16    
HELIX  192 AV3 THR 0   49  ARG 0   61  1                                  13    
HELIX  193 AV4 THR 0   76  GLU 0   98  1                                  23    
HELIX  194 AV5 SER 0  111  LEU 0  115  5                                   5    
HELIX  195 AV6 GLY 0  127  SER 0  140  1                                  14    
HELIX  196 AV7 CYS 0  155  GLU 0  167  1                                  13    
HELIX  197 AV8 ASN 0  176  ARG 0  186  1                                  11    
HELIX  198 AV9 CYS 0  190  LEU 0  200  1                                  11    
HELIX  199 AW1 ASN 0  241  SER 0  246  1                                   6    
HELIX  200 AW2 ARG 0  253  ARG 0  272  1                                  20    
HELIX  201 AW3 GLU 0  275  GLY 0  291  1                                  17    
HELIX  202 AW4 GLU 0  294  ALA 0  298  5                                   5    
HELIX  203 AW5 ARG 0  299  HIS 0  304  1                                   6    
HELIX  204 AW6 ARG 0  324  GLU 0  338  1                                  15    
HELIX  205 AW7 GLU 0  338  GLN 0  347  1                                  10    
HELIX  206 AW8 SER 0  353  VAL 0  365  1                                  13    
HELIX  207 AW9 LYS 0  370  GLU 0  387  1                                  18    
HELIX  208 AX1 ASP 0  390  THR 0  409  1                                  20    
HELIX  209 AX2 ILE 0  444  PHE 0  451  1                                   8    
HELIX  210 AX3 ILE 0  466  ILE 0  470  5                                   5    
HELIX  211 AX4 ILE 0  514  SER 0  528  1                                  15    
HELIX  212 AX5 SER 0  541  GLY 0  556  1                                  16    
HELIX  213 AX6 ILE 0  557  LYS 0  565  1                                   9    
HELIX  214 AX7 GLY 0  574  GLY 0  591  1                                  18    
HELIX  215 AX8 SER 0  630  TYR 0  639  1                                  10    
HELIX  216 AX9 TYR 0  639  PHE 0  644  1                                   6    
HELIX  217 AY1 GLN 0  645  GLU 0  648  5                                   4    
HELIX  218 AY2 ASN 0  649  GLY 0  665  1                                  17    
HELIX  219 AY3 ARG 0  686  ARG 0  690  5                                   5    
HELIX  220 AY4 LEU 0  693  GLN 0  698  1                                   6    
HELIX  221 AY5 THR 0  709  MET 0  724  1                                  16    
HELIX  222 AY6 LEU 0  738  GLU 0  742  5                                   5    
HELIX  223 AY7 GLU 1   88  LEU 1   96  1                                   9    
HELIX  224 AY8 ASN 1  115  GLU 1  120  1                                   6    
HELIX  225 AY9 ASP 1  121  VAL 1  132  1                                  12    
HELIX  226 AZ1 SER 1  138  TRP 1  143  1                                   6    
HELIX  227 AZ2 ASN 1  150  SER 1  155  1                                   6    
HELIX  228 AZ3 SER 1  156  ASN 1  159  5                                   4    
HELIX  229 AZ4 ILE 1  193  TYR 1  200  1                                   8    
HELIX  230 AZ5 TYR 1  200  GLU 1  209  1                                  10    
HELIX  231 AZ6 THR 1  216  GLU 1  219  5                                   4    
HELIX  232 AZ7 PHE 1  220  PHE 1  225  1                                   6    
HELIX  233 AZ8 GLY 1  238  GLY 1  261  1                                  24    
HELIX  234 AZ9 PRO 1  265  LYS 1  275  1                                  11    
HELIX  235 BA1 ILE 1  295  ASN 1  300  1                                   6    
HELIX  236 BA2 ASN 1  300  ARG 1  320  1                                  21    
HELIX  237 BA3 GLU 1  331  MET 1  335  5                                   5    
HELIX  238 BA4 LYS 1  350  LEU 1  363  1                                  14    
HELIX  239 BA5 GLY 1  364  ASN 1  367  5                                   4    
HELIX  240 BA6 LEU 1  374  GLY 1  385  1                                  12    
HELIX  241 BA7 GLN 1  390  GLN 1  409  1                                  20    
HELIX  242 BA8 GLU 1  410  TYR 1  414  5                                   5    
HELIX  243 BA9 LYS 1  417  SER 1  435  1                                  19    
HELIX  244 BB1 ALA 1  448  MET 1  452  5                                   5    
HELIX  245 BB2 ASP 1  456  SER 1  477  1                                  22    
HELIX  246 BB3 GLU 1  488  LYS 1  504  1                                  17    
HELIX  247 BB4 LYS 1  504  GLN 1  509  1                                   6    
HELIX  248 BB5 ARG 1  514  THR 1  519  1                                   6    
HELIX  249 BB6 ASN 1  520  VAL 1  522  5                                   3    
HELIX  250 BB7 ILE 1  525  TRP 1  539  1                                  15    
HELIX  251 BB8 LEU 2    9  LEU 2   14  1                                   6    
HELIX  252 BB9 LEU 2   14  GLY 2   24  1                                  11    
HELIX  253 BC1 SER 2   27  TYR 2   35  1                                   9    
HELIX  254 BC2 GLY 2   36  CYS 2   41  1                                   6    
HELIX  255 BC3 PRO 2   49  LEU 2   62  1                                  14    
HELIX  256 BC4 GLN 2   68  VAL 2   75  1                                   8    
HELIX  257 BC5 PHE 2   79  GLU 2   84  1                                   6    
HELIX  258 BC6 SER 2   86  ARG 2   94  1                                   9    
HELIX  259 BC7 ASN 2  111  ALA 2  121  1                                  11    
HELIX  260 BC8 LYS 2  127  ASP 2  131  5                                   5    
HELIX  261 BC9 ASP 2  144  GLY 2  165  1                                  22    
HELIX  262 BD1 LEU 2  175  GLN 2  181  1                                   7    
HELIX  263 BD2 ALA 2  199  ASP 2  207  1                                   9    
HELIX  264 BD3 PRO 2  209  LEU 2  217  1                                   9    
HELIX  265 BD4 GLN 2  218  ALA 2  223  5                                   6    
HELIX  266 BD5 GLY 2  227  PHE 2  236  1                                  10    
HELIX  267 BD6 LEU 2  237  SER 2  241  5                                   5    
HELIX  268 BD7 ASP 2  248  GLY 2  253  1                                   6    
HELIX  269 BD8 SER 2  255  GLU 2  267  1                                  13    
HELIX  270 BD9 LYS 2  275  SER 2  278  5                                   4    
HELIX  271 BE1 ALA 2  287  GLY 2  293  1                                   7    
HELIX  272 BE2 GLN 2  324  SER 2  332  1                                   9    
HELIX  273 BE3 GLU 2  349  ALA 2  356  1                                   8    
HELIX  274 BE4 ALA 2  361  THR 2  370  1                                  10    
HELIX  275 BE5 PRO 2  374  GLN 2  379  1                                   6    
HELIX  276 BE6 THR 2  386  GLU 2  397  1                                  12    
HELIX  277 BE7 ARG 2  398  ARG 2  400  5                                   3    
HELIX  278 BE8 GLN 2  415  LEU 2  428  1                                  14    
HELIX  279 BE9 GLY 2  447  GLN 2  458  1                                  12    
HELIX  280 BF1 GLU 3   32  VAL 3   40  1                                   9    
HELIX  281 BF2 VAL 3   68  LEU 3   79  1                                  12    
HELIX  282 BF3 LYS 3   84  PHE 3   89  1                                   6    
HELIX  283 BF4 PHE 3   98  LEU 3  109  1                                  12    
HELIX  284 BF5 LEU 3  115  ILE 3  124  1                                  10    
HELIX  285 BF6 VAL 3  132  ASP 3  185  1                                  54    
HELIX  286 BF7 ALA 3  195  LYS 3  214  1                                  20    
HELIX  287 BF8 ARG 3  268  VAL 3  275  1                                   8    
HELIX  288 BF9 SER 3  290  SER 3  302  1                                  13    
HELIX  289 BG1 ASN 4   18  ALA 4   26  1                                   9    
HELIX  290 BG2 LEU 4   27  GLU 4   29  5                                   3    
HELIX  291 BG3 THR 4   33  ASN 4   52  1                                  20    
HELIX  292 BG4 GLU 4  102  LYS 4  121  1                                  20    
HELIX  293 BG5 LEU 4  133  LYS 4  152  1                                  20    
HELIX  294 BG6 TYR 4  174  LYS 4  186  1                                  13    
HELIX  295 BG7 GLN 4  204  THR 4  210  1                                   7    
HELIX  296 BG8 LEU 4  293  LYS 4  298  1                                   6    
HELIX  297 BG9 ASP 5   13  ALA 5   15  5                                   3    
HELIX  298 BH1 MET 5   16  GLU 5   25  1                                  10    
HELIX  299 BH2 ILE 5   46  GLU 5   48  5                                   3    
HELIX  300 BH3 LEU 5   49  GLN 5   54  1                                   6    
HELIX  301 BH4 ARG 5   56  ALA 5   65  1                                  10    
HELIX  302 BH5 TRP 6   11  GLU 6   24  1                                  14    
HELIX  303 BH6 ASP 6   25  GLY 6   28  5                                   4    
HELIX  304 BH7 ALA 6   32  ARG 6   43  1                                  12    
HELIX  305 BH8 ARG 6   80  ASN 6   99  1                                  20    
HELIX  306 BH9 ASN 6  123  LYS 6  133  1                                  11    
HELIX  307 BI1 ALA 6  134  ASP 6  136  5                                   3    
HELIX  308 BI2 SER 6  144  LYS 6  157  1                                  14    
HELIX  309 BI3 ILE 6  182  LYS 6  190  1                                   9    
HELIX  310 BI4 CYS 6  208  THR 6  215  1                                   8    
HELIX  311 BI5 ASP 6  224  HIS 6  235  1                                  12    
HELIX  312 BI6 LEU 6  318  LEU 6  325  1                                   8    
HELIX  313 BI7 CYS 6  368  SER 6  378  1                                  11    
HELIX  314 BI8 CYS 6  382  ILE 6  386  5                                   5    
HELIX  315 BI9 ASP 7   60  MET 7   65  1                                   6    
HELIX  316 BJ1 LYS 7   94  ILE 7  103  1                                  10    
HELIX  317 BJ2 GLN 7  132  SER 7  144  1                                  13    
HELIX  318 BJ3 HIS 7  181  GLN 7  186  1                                   6    
HELIX  319 BJ4 GLU 7  278  TYR 7  289  1                                  12    
HELIX  320 BJ5 ARG 7  317  PHE 7  328  1                                  12    
HELIX  321 BJ6 GLY 7  345  ARG 7  358  1                                  14    
HELIX  322 BJ7 ALA 7  368  PHE 7  378  1                                  11    
HELIX  323 BJ8 THR 7  383  SER 7  387  5                                   5    
HELIX  324 BJ9 SER 7  420  TRP 7  429  1                                  10    
HELIX  325 BK1 TRP 7  429  GLU 7  434  1                                   6    
HELIX  326 BK2 PRO 7  447  VAL 7  458  1                                  12    
HELIX  327 BK3 ASN 7  492  ASN 7  498  1                                   7    
HELIX  328 BK4 SER 7  515  ARG 7  520  1                                   6    
HELIX  329 BK5 THR 7  527  LYS 7  529  5                                   3    
HELIX  330 BK6 ARG 7  530  MET 7  536  1                                   7    
HELIX  331 BK7 ASN 7  537  ARG 7  553  1                                  17    
HELIX  332 BK8 LYS 7  569  ARG 7  574  1                                   6    
HELIX  333 BK9 SER 7  585  ASN 7  595  1                                  11    
HELIX  334 BL1 ARG 7  634  LEU 7  644  1                                  11    
HELIX  335 BL2 GLU 7  669  THR 7  674  1                                   6    
HELIX  336 BL3 THR 7  674  VAL 7  681  1                                   8    
HELIX  337 BL4 THR 7  705  LEU 7  712  1                                   8    
HELIX  338 BL5 LEU 7  712  LEU 7  717  1                                   6    
HELIX  339 BL6 ASN 8   56  LEU 8   60  5                                   5    
HELIX  340 BL7 ARG 8   61  LEU 8   66  1                                   6    
HELIX  341 BL8 LEU 8   98  LYS 8  103  1                                   6    
HELIX  342 BL9 ILE 8  114  HIS 8  131  1                                  18    
HELIX  343 BM1 ALA 8  180  PHE 8  185  1                                   6    
HELIX  344 BM2 GLY 8  191  ASP 8  195  5                                   5    
HELIX  345 BM3 MET 8  196  ARG 8  209  1                                  14    
HELIX  346 BM4 SER 8  217  LEU 8  229  1                                  13    
HELIX  347 BM5 GLY 8  265  PHE 8  276  1                                  12    
HELIX  348 BM6 ALA 8  286  LYS 8  291  1                                   6    
HELIX  349 BM7 SER 9   15  ALA 9   36  1                                  22    
HELIX  350 BM8 GLU 9   52  VAL 9   70  1                                  19    
HELIX  351 BM9 PRO 9   76  TYR 9   91  1                                  16    
HELIX  352 BN1 HIS 9  100  LEU 9  111  1                                  12    
HELIX  353 BN2 SER 9  121  GLY 9  127  1                                   7    
HELIX  354 BN3 LEU 9  134  GLN 9  153  1                                  20    
HELIX  355 BN4 PRO 9  166  TYR 9  178  1                                  13    
HELIX  356 BN5 GLU 9  185  LEU 9  200  1                                  16    
HELIX  357 BN6 THR 9  208  ARG 9  223  1                                  16    
HELIX  358 BN7 LEU 9  236  ASN 9  241  5                                   6    
HELIX  359 BN8 LEU 9  245  LYS 9  261  1                                  17    
HELIX  360 BN9 ARG 9  266  SER 9  282  1                                  17    
SHEET    1 AA1 3 SER A1448  ASP A1449  0                                        
SHEET    2 AA1 3 ARG A  20  GLN A  22 -1  N  VAL A  21   O  ASP A1449           
SHEET    3 AA1 3 ARG B1170  MET B1172 -1  O  ARG B1170   N  GLN A  22           
SHEET    1 AA2 2 GLY A  86  VAL A  94  0                                        
SHEET    2 AA2 2 VAL A 250  VAL A 255 -1  O  LEU A 253   N  ILE A  88           
SHEET    1 AA3 2 GLY A 157  GLU A 158  0                                        
SHEET    2 AA3 2 LYS A 179  GLY A 180 -1  O  LYS A 179   N  GLU A 158           
SHEET    1 AA4 3 ARG A 190  ARG A 193  0                                        
SHEET    2 AA4 3 LEU A 198  HIS A 204 -1  O  GLU A 201   N  ARG A 190           
SHEET    3 AA4 3 ASP A 208  LEU A 215 -1  N  ASP A 208   O  HIS A 204           
SHEET    1 AA5 2 ARG A 358  VAL A 359  0                                        
SHEET    2 AA5 2 LEU B1084  ARG B1085 -1  O  LEU B1084   N  VAL A 359           
SHEET    1 AA6 3 THR A 481  LEU A 484  0                                        
SHEET    2 AA6 3 SER A 362  PRO A 369  1  N  VAL A 366   O  PHE A 482           
SHEET    3 AA6 3 GLU A 500  HIS A 504 -1  O  LEU A 503   N  ALA A 363           
SHEET    1 AA7 4 THR A 389  ILE A 393  0                                        
SHEET    2 AA7 4 LYS A 445  HIS A 449 -1  O  VAL A 446   N  GLU A 392           
SHEET    3 AA7 4 ALA A 416  ILE A 420 -1  N  ILE A 420   O  LYS A 445           
SHEET    4 AA7 4 ARG A 426  ASP A 428 -1  O  ILE A 427   N  ILE A 419           
SHEET    1 AA8 2 ILE A 455  ASN A 459  0                                        
SHEET    2 AA8 2 MET A 469  ARG A 473 -1  O  HIS A 472   N  VAL A 456           
SHEET    1 AA9 2 VAL A 526  THR A 527  0                                        
SHEET    2 AA9 2 ARG A 532  PRO A 533 -1  O  ARG A 532   N  THR A 527           
SHEET    1 AB1 2 PHE A 554  LEU A 555  0                                        
SHEET    2 AB1 2 TRP A 586  THR A 587 -1  O  TRP A 586   N  LEU A 555           
SHEET    1 AB2 8 ILE A 579  LYS A 581  0                                        
SHEET    2 AB2 8 VAL H  91  TYR H  93 -1  O  VAL H  91   N  LYS A 581           
SHEET    3 AB2 8 TYR H 142  LYS H 146 -1  O  LEU H 143   N  MET H  92           
SHEET    4 AB2 8 ARG H  57  ALA H  61 -1  N  ALA H  61   O  TYR H 142           
SHEET    5 AB2 8 ILE H   4  ASP H  14 -1  N  PHE H   6   O  ILE H  60           
SHEET    6 AB2 8 HIS H  29  SER H  32 -1  O  HIS H  29   N  LYS H  13           
SHEET    7 AB2 8 ASP H  38  VAL H  43 -1  O  LEU H  39   N  CYS H  30           
SHEET    8 AB2 8 SER H  26  ARG H  27 -1  N  SER H  26   O  VAL H  43           
SHEET    1 AB310 ILE A 579  LYS A 581  0                                        
SHEET    2 AB310 VAL H  91  TYR H  93 -1  O  VAL H  91   N  LYS A 581           
SHEET    3 AB310 TYR H 142  LYS H 146 -1  O  LEU H 143   N  MET H  92           
SHEET    4 AB310 ARG H  57  ALA H  61 -1  N  ALA H  61   O  TYR H 142           
SHEET    5 AB310 ILE H   4  ASP H  14 -1  N  PHE H   6   O  ILE H  60           
SHEET    6 AB310 HIS H  29  SER H  32 -1  O  HIS H  29   N  LYS H  13           
SHEET    7 AB310 ASP H  38  VAL H  43 -1  O  LEU H  39   N  CYS H  30           
SHEET    8 AB310 LEU H 121  GLY H 127 -1  O  LEU H 122   N  ASP H  42           
SHEET    9 AB310 LEU H 112  TYR H 118 -1  N  ALA H 114   O  LEU H 125           
SHEET   10 AB310 LYS H  95  ILE H  99 -1  N  ARG H  98   O  TYR H 115           
SHEET    1 AB4 2 VAL A 629  GLU A 631  0                                        
SHEET    2 AB4 2 GLU A 634  MET A 637 -1  O  GLU A 634   N  GLU A 631           
SHEET    1 AB5 2 MET A 872  VAL A 873  0                                        
SHEET    2 AB5 2 VAL A 879  ARG A 880 -1  O  ARG A 880   N  MET A 872           
SHEET    1 AB6 2 VAL A 901  PHE A 903  0                                        
SHEET    2 AB6 2 VAL A 978  PRO A 980 -1  O  LEU A 979   N  GLU A 902           
SHEET    1 AB7 2 LEU A1139  VAL A1141  0                                        
SHEET    2 AB7 2 LEU A1336  THR A1338 -1  O  LEU A1336   N  VAL A1141           
SHEET    1 AB8 4 THR A1170  TYR A1177  0                                        
SHEET    2 AB8 4 TRP A1210  LEU A1216 -1  O  GLU A1215   N  ALA A1171           
SHEET    3 AB8 4 LEU A1255  ARG A1260 -1  O  LEU A1255   N  LEU A1216           
SHEET    4 AB8 4 ASN A1244  PHE A1247 -1  N  ASN A1244   O  ARG A1260           
SHEET    1 AB9 2 ILE A1320  ILE A1321  0                                        
SHEET    2 AB9 2 LYS A1329  ALA A1330 -1  O  LYS A1329   N  ILE A1321           
SHEET    1 AC1 3 PHE A1471  LEU A1473  0                                        
SHEET    2 AC1 3 ILE F 106  TYR F 109 -1  O  ARG F 107   N  ASP A1472           
SHEET    3 AC1 3 TYR F 115  TRP F 118 -1  O  TRP F 118   N  ILE F 106           
SHEET    1 AC2 3 LEU B  86  LEU B  93  0                                        
SHEET    2 AC2 3 SER B 121  LYS B 130 -1  O  THR B 129   N  LYS B  87           
SHEET    3 AC2 3 GLN B 143  GLN B 145 -1  O  GLN B 143   N  LYS B 130           
SHEET    1 AC3 3 LEU B  86  LEU B  93  0                                        
SHEET    2 AC3 3 SER B 121  LYS B 130 -1  O  THR B 129   N  LYS B  87           
SHEET    3 AC3 3 GLY B 150  PRO B 153 -1  O  GLY B 150   N  LEU B 124           
SHEET    1 AC4 2 THR B  97  TRP B  99  0                                        
SHEET    2 AC4 2 PRO B 105  PRO B 107 -1  O  SER B 106   N  HIS B  98           
SHEET    1 AC5 3 PHE B 185  ILE B 187  0                                        
SHEET    2 AC5 3 SER B 190  LEU B 194 -1  O  SER B 190   N  ILE B 187           
SHEET    3 AC5 3 SER B 467  VAL B 469 -1  O  GLN B 468   N  VAL B 193           
SHEET    1 AC6 2 GLN B 197  MET B 200  0                                        
SHEET    2 AC6 2 LYS B 391  ASP B 394 -1  O  ARG B 392   N  LYS B 199           
SHEET    1 AC7 3 PHE B 208  ALA B 209  0                                        
SHEET    2 AC7 3 TYR B 215  ARG B 222 -1  O  THR B 218   N  PHE B 208           
SHEET    3 AC7 3 THR B 234  LEU B 240 -1  O  VAL B 237   N  GLY B 219           
SHEET    1 AC8 3 TYR B 531  ILE B 532  0                                        
SHEET    2 AC8 3 ILE B 621  GLU B 629 -1  O  CYS B 622   N  TYR B 531           
SHEET    3 AC8 3 VAL B 662  ILE B 665 -1  O  ILE B 665   N  ARG B 623           
SHEET    1 AC9 4 LYS B 632  LEU B 633  0                                        
SHEET    2 AC9 4 ILE B 621  GLU B 629 -1  N  GLU B 629   O  LYS B 632           
SHEET    3 AC9 4 HIS B 695  CYS B 696 -1  O  CYS B 696   N  LEU B 626           
SHEET    4 AC9 4 LEU B 675  ALA B 676  1  N  ALA B 676   O  HIS B 695           
SHEET    1 AD1 3 CYS B 572  HIS B 577  0                                        
SHEET    2 AD1 3 THR B 565  VAL B 569 -1  N  VAL B 569   O  CYS B 572           
SHEET    3 AD1 3 GLU B 611  ILE B 614  1  O  ILE B 612   N  PHE B 568           
SHEET    1 AD2 4 ALA B 748  LEU B 751  0                                        
SHEET    2 AD2 4 SER B 808  GLU B 816 -1  O  TYR B 811   N  ALA B 748           
SHEET    3 AD2 4 LYS B 917  ARG B 927 -1  O  VAL B 923   N  ARG B 812           
SHEET    4 AD2 4 ILE B 903  LEU B 911 -1  N  ILE B 903   O  ARG B 924           
SHEET    1 AD3 5 THR B 944  TYR B 949  0                                        
SHEET    2 AD3 5 SER B 793  ASN B 797  1  N  VAL B 794   O  THR B 944           
SHEET    3 AD3 5 ILE B 965  ILE B 967 -1  O  ILE B 966   N  ILE B 795           
SHEET    4 AD3 5 ASN B 777  ILE B 782  1  O  ILE B 779   N  ILE B 965           
SHEET    5 AD3 5 PRO B1045  TYR B1047 -1  O  THR B1046   N  SER B 778           
SHEET    1 AD4 2 VAL B 865  ILE B 867  0                                        
SHEET    2 AD4 2 THR B 894  PHE B 895 -1  O  THR B 894   N  ILE B 867           
SHEET    1 AD5 2 THR B 870  VAL B 871  0                                        
SHEET    2 AD5 2 ARG B 890  ASP B 891 -1  O  ARG B 890   N  VAL B 871           
SHEET    1 AD6 2 ASN B1025  GLU B1026  0                                        
SHEET    2 AD6 2 ILE B1041  PHE B1042 -1  O  ILE B1041   N  GLU B1026           
SHEET    1 AD7 2 GLN B1115  CYS B1119  0                                        
SHEET    2 AD7 2 ILE B1146  ARG B1150 -1  O  SER B1147   N  VAL B1118           
SHEET    1 AD8 4 THR C   8  LEU C  14  0                                        
SHEET    2 AD8 4 ASN C  18  GLU C  24 -1  O  LYS C  20   N  GLU C  13           
SHEET    3 AD8 4 PHE C 229  SER C 235 -1  O  PHE C 229   N  ILE C  23           
SHEET    4 AD8 4 THR C 179  TYR C 186 -1  N  GLU C 185   O  TYR C 230           
SHEET    1 AD9 4 ILE C  44  ASN C  55  0                                        
SHEET    2 AD9 4 GLN C 157  GLY C 168 -1  O  ARG C 162   N  GLN C  51           
SHEET    3 AD9 4 PHE C 101  CYS C 107 -1  N  PHE C 101   O  ALA C 163           
SHEET    4 AD9 4 LEU C 120  ILE C 121 -1  O  ILE C 121   N  THR C 102           
SHEET    1 AE1 2 ARG C 113  HIS C 114  0                                        
SHEET    2 AE1 2 LYS C 152  LEU C 153 -1  O  LEU C 153   N  ARG C 113           
SHEET    1 AE2 4 GLU D  30  LEU D  32  0                                        
SHEET    2 AE2 4 PHE G   2  HIS G   4 -1  O  PHE G   2   N  LEU D  32           
SHEET    3 AE2 4 ARG G  63  PHE G  77 -1  O  VAL G  76   N  TYR G   3           
SHEET    4 AE2 4 VAL G  48  ILE G  54 -1  N  ASN G  53   O  LYS G  71           
SHEET    1 AE3 3 LEU G   7  LEU G  13  0                                        
SHEET    2 AE3 3 ARG G  63  PHE G  77 -1  O  VAL G  66   N  LEU G  13           
SHEET    3 AE3 3 VAL G  58  GLN G  60 -1  N  VAL G  58   O  LEU G  67           
SHEET    1 AE4 4 VAL E  60  VAL E  62  0                                        
SHEET    2 AE4 4 MET E  72  VAL E  74 -1  O  VAL E  74   N  VAL E  60           
SHEET    3 AE4 4 ARG E 101  VAL E 106  1  O  LEU E 103   N  PHE E  73           
SHEET    4 AE4 4 ILE E 126  LEU E 131  1  O  PHE E 130   N  ILE E 104           
SHEET    1 AE5 3 GLU E 147  VAL E 149  0                                        
SHEET    2 AE5 3 VAL E 190  ARG E 195 -1  O  ILE E 194   N  GLU E 147           
SHEET    3 AE5 3 TYR E 203  LEU E 208 -1  O  TYR E 203   N  ARG E 195           
SHEET    1 AE6 6 VAL G  84  VAL G  92  0                                        
SHEET    2 AE6 6 LEU G  97  ILE G 101 -1  O  PHE G  98   N  GLN G  91           
SHEET    3 AE6 6 MET G 104  ILE G 108 -1  O  CYS G 106   N  THR G  99           
SHEET    4 AE6 6 PHE G 158  SER G 162  1  O  GLY G 161   N  PHE G 107           
SHEET    5 AE6 6 GLU G 142  ARG G 151 -1  N  VAL G 148   O  ILE G 160           
SHEET    6 AE6 6 VAL G  84  VAL G  92 -1  N  VAL G  85   O  LEU G 145           
SHEET    1 AE7 3 GLU G 118  PHE G 119  0                                        
SHEET    2 AE7 3 TYR G 128  LYS G 129 -1  N  LYS G 129   O  GLU G 118           
SHEET    3 AE7 3 VAL G 136  ILE G 137 -1  O  ILE G 137   N  TYR G 128           
SHEET    1 AE8 3 TYR I  25  ASP I  29  0                                        
SHEET    2 AE8 3 ILE I  34  ALA I  38 -1  O  LEU I  36   N  LYS I  27           
SHEET    3 AE8 3 GLN I  45  GLU I  47 -1  O  GLN I  46   N  TYR I  37           
SHEET    1 AE9 4 ILE K  19  THR K  20  0                                        
SHEET    2 AE9 4 CYS K  31  ASN K  36 -1  O  THR K  34   N  THR K  20           
SHEET    3 AE9 4 LYS K  70  THR K  77 -1  O  ILE K  73   N  PHE K  33           
SHEET    4 AE9 4 VAL K  56  LYS K  62 -1  N  PHE K  58   O  GLN K  76           
SHEET    1 AF1 2 ILE L  18  CYS L  19  0                                        
SHEET    2 AF1 2 MET L  44  TYR L  45 -1  O  TYR L  45   N  ILE L  18           
SHEET    1 AF2 7 ASN N 333  SER N 345  0                                        
SHEET    2 AF2 7 LYS N 348  LEU N 360 -1  O  LYS N 348   N  SER N 345           
SHEET    3 AF2 7 ARG N 363  GLU N 375 -1  O  ALA N 370   N  LEU N 353           
SHEET    4 AF2 7 ASN O  57  PHE O  67  1  O  LEU O  62   N  GLU N 375           
SHEET    5 AF2 7 VAL O  71  ARG O  82 -1  O  GLU O  80   N  ARG O  59           
SHEET    6 AF2 7 LYS O  89  CYS O  98 -1  O  ILE O  95   N  PHE O  74           
SHEET    7 AF2 7 ASN N 333  SER N 345  1  N  VAL N 335   O  VAL O  96           
SHEET    1 AF3 6 ALA P 190  ASN P 193  0                                        
SHEET    2 AF3 6 PHE P 197  MET P 202 -1  O  ILE P 201   N  GLU P 191           
SHEET    3 AF3 6 THR P 210  ILE P 213 -1  O  ILE P 213   N  VAL P 200           
SHEET    4 AF3 6 LYS P 218  ALA P 224 -1  O  THR P 222   N  THR P 210           
SHEET    5 AF3 6 GLN P 164  ASN P 173 -1  N  VAL P 172   O  MET P 219           
SHEET    6 AF3 6 LEU P 251  SER P 261 -1  O  ASN P 257   N  VAL P 169           
SHEET    1 AF4 4 SER P 281  GLU P 284  0                                        
SHEET    2 AF4 4 PHE P 288  MET P 295 -1  O  ILE P 292   N  SER P 282           
SHEET    3 AF4 4 ILE P 300  ILE P 304 -1  O  ILE P 304   N  LEU P 291           
SHEET    4 AF4 4 VAL P 311  THR P 313 -1  O  THR P 313   N  VAL P 301           
SHEET    1 AF5 2 ARG Q  75  THR Q  80  0                                        
SHEET    2 AF5 2 THR Q  86  TYR Q  91 -1  O  THR Q  87   N  GLU Q  79           
SHEET    1 AF6 2 PHE Q 127  CYS Q 129  0                                        
SHEET    2 AF6 2 SER Q 134  PHE Q 136 -1  O  PHE Q 136   N  PHE Q 127           
SHEET    1 AF7 2 ILE Q 395  VAL Q 398  0                                        
SHEET    2 AF7 2 ARG Q 401  SER Q 404 -1  O  PHE Q 403   N  VAL Q 396           
SHEET    1 AF8 2 ILE R 166  LEU R 167  0                                        
SHEET    2 AF8 2 ILE R 200  LEU R 201 -1  O  LEU R 201   N  ILE R 166           
SHEET    1 AF911 LYS S  24  ALA S  30  0                                        
SHEET    2 AF911 LEU T  93  SER T  99 -1  O  THR T  94   N  MET S  29           
SHEET    3 AF911 LYS T 103  CYS T 116 -1  O  LYS T 103   N  SER T  99           
SHEET    4 AF911 GLU T  80  GLN T  86 -1  N  GLN T  86   O  ARG T 113           
SHEET    5 AF911 THR T  52  LEU T  58 -1  N  VAL T  54   O  PHE T  83           
SHEET    6 AF911 GLU T  39  LYS T  47 -1  N  ALA T  46   O  GLU T  53           
SHEET    7 AF911 THR S  12  ARG S  17 -1  N  TYR S  14   O  LEU T  43           
SHEET    8 AF911 PHE S 135  PRO S 139  1  O  PHE S 135   N  ARG S  17           
SHEET    9 AF911 SER S 123  GLN S 129 -1  N  ILE S 126   O  PHE S 138           
SHEET   10 AF911 GLY T  17  VAL T  23 -1  O  VAL T  23   N  SER S 123           
SHEET   11 AF911 LYS T 103  CYS T 116  1  O  ALA T 114   N  LEU T  20           
SHEET    1 AG1 4 GLU S  48  ARG S  49  0                                        
SHEET    2 AG1 4 TRP S  98  VAL S 102 -1  O  LEU S  99   N  GLU S  48           
SHEET    3 AG1 4 ARG S 108  LYS S 114 -1  O  ARG S 108   N  VAL S 102           
SHEET    4 AG1 4 TYR S 144  PRO S 148 -1  O  THR S 147   N  LYS S 111           
SHEET    1 AG2 3 TYR T 197  ASN T 198  0                                        
SHEET    2 AG2 3 THR T 232  LEU T 235 -1  O  TRP T 233   N  TYR T 197           
SHEET    3 AG2 3 GLY T 221  ASN T 224 -1  N  ASN T 224   O  THR T 232           
SHEET    1 AG3 3 CYS U 271  THR U 274  0                                        
SHEET    2 AG3 3 PHE U 288  CYS U 291 -1  O  VAL U 290   N  THR U 272           
SHEET    3 AG3 3 ASN U 296  LYS U 299 -1  O  ASN U 296   N  CYS U 291           
SHEET    1 AG4 7 GLY 0 106  ALA 0 108  0                                        
SHEET    2 AG4 7 VAL 0 204  SER 0 208  1  O  VAL 0 204   N  LEU 0 107           
SHEET    3 AG4 7 ILE 0  71  SER 0  74  1  N  TYR 0  72   O  VAL 0 205           
SHEET    4 AG4 7 VAL 0 230  VAL 0 232  1  O  VAL 0 232   N  ILE 0  71           
SHEET    5 AG4 7 SER 0 453  SER 0 458  1  O  ILE 0 455   N  VAL 0 231           
SHEET    6 AG4 7 GLY 0  38  GLU 0  41  1  N  GLY 0  38   O  VAL 0 454           
SHEET    7 AG4 7 VAL 0 476  MET 0 478  1  O  VAL 0 476   N  VAL 0  39           
SHEET    1 AG5 3 VAL 0 249  THR 0 252  0                                        
SHEET    2 AG5 3 ILE 0 432  PHE 0 435 -1  O  PHE 0 435   N  VAL 0 249           
SHEET    3 AG5 3 ILE 0 417  ILE 0 418 -1  N  ILE 0 417   O  HIS 0 434           
SHEET    1 AG6 6 PRO 0 492  ILE 0 495  0                                        
SHEET    2 AG6 6 LEU 0 676  ALA 0 680  1  O  PHE 0 679   N  MET 0 493           
SHEET    3 AG6 6 ALA 0 617  PHE 0 621  1  N  VAL 0 618   O  LEU 0 676           
SHEET    4 AG6 6 ILE 0 535  PHE 0 539  1  N  VAL 0 536   O  ALA 0 617           
SHEET    5 AG6 6 ILE 0 595  VAL 0 599  1  O  LEU 0 596   N  ILE 0 535           
SHEET    6 AG6 6 LEU 0 567  ILE 0 569  1  N  PHE 0 568   O  LEU 0 597           
SHEET    1 AG7 4 VAL 1  15  ARG 1  16  0                                        
SHEET    2 AG7 4 THR 1  74  PHE 1  79 -1  O  HIS 1  78   N  ARG 1  16           
SHEET    3 AG7 4 GLN 1  64  VAL 1  68 -1  N  LEU 1  65   O  PHE 1  77           
SHEET    4 AG7 4 GLN 1  53  LYS 1  54 -1  N  LYS 1  54   O  GLN 1  66           
SHEET    1 AG8 3 TYR 1  25  LEU 1  26  0                                        
SHEET    2 AG8 3 ILE 1  31  TRP 1  33 -1  O  ALA 1  32   N  TYR 1  25           
SHEET    3 AG8 3 ILE 1  43  SER 1  44 -1  O  ILE 1  43   N  TRP 1  33           
SHEET    1 AG9 3 LEU 2  66  PRO 2  67  0                                        
SHEET    2 AG9 3 GLY 2 107  LEU 2 110 -1  O  LEU 2 108   N  LEU 2  66           
SHEET    3 AG9 3 TRP 2  96  THR 2  98 -1  N  HIS 2  97   O  ILE 2 109           
SHEET    1 AH1 2 VAL 2 271  GLN 2 273  0                                        
SHEET    2 AH1 2 TYR 2 281  PRO 2 283 -1  O  TYR 2 282   N  PHE 2 272           
SHEET    1 AH2 6 LEU 2 431  ASN 2 435  0                                        
SHEET    2 AH2 6 LEU 2 440  VAL 2 443 -1  O  VAL 2 442   N  PHE 2 433           
SHEET    3 AH2 6 THR 2 404  TYR 2 409 -1  N  VAL 2 407   O  VAL 2 443           
SHEET    4 AH2 6 LEU 5   5  GLU 5  11 -1  O  GLY 5   7   N  GLY 2 406           
SHEET    5 AH2 6 HIS 5  42  VAL 5  43 -1  O  VAL 5  43   N  ILE 5  10           
SHEET    6 AH2 6 ASP 5  37  ASP 5  39 -1  N  ILE 5  38   O  HIS 5  42           
SHEET    1 AH3 2 LEU 3  21  VAL 3  23  0                                        
SHEET    2 AH3 2 THR 3  29  CYS 3  31 -1  O  LEU 3  30   N  MET 3  22           
SHEET    1 AH4 4 PHE 4  69  TYR 4  71  0                                        
SHEET    2 AH4 4 LYS 4  56  ALA 4  61 -1  N  VAL 4  59   O  TYR 4  71           
SHEET    3 AH4 4 ASN 4   9  VAL 4  15  1  N  ILE 4  13   O  ILE 4  60           
SHEET    4 AH4 4 LYS 4 158  VAL 4 163  1  O  LEU 4 162   N  VAL 4  12           
SHEET    1 AH5 2 ALA 4 193  VAL 4 195  0                                        
SHEET    2 AH5 2 TYR 4 214  LYS 4 216  1  O  LEU 4 215   N  ALA 4 193           
SHEET    1 AH6 5 ILE 6 106  THR 6 109  0                                        
SHEET    2 AH6 5 VAL 6  63  ASP 6  66  1  N  VAL 6  65   O  ILE 6 107           
SHEET    3 AH6 5 GLU 6 166  ILE 6 170  1  O  LEU 6 168   N  VAL 6  64           
SHEET    4 AH6 5 ARG 6 195  GLY 6 200  1  O  SER 6 197   N  VAL 6 167           
SHEET    5 AH6 5 TYR 6 219  VAL 6 221  1  O  HIS 6 220   N  GLY 6 200           
SHEET    1 AH7 2 TYR 6 289  PHE 6 290  0                                        
SHEET    2 AH7 2 LYS 6 297  TYR 6 298 -1  O  TYR 6 298   N  TYR 6 289           
SHEET    1 AH8 2 GLN 6 332  GLU 6 333  0                                        
SHEET    2 AH8 2 TYR 6 358  VAL 6 359 -1  O  VAL 6 359   N  GLN 6 332           
SHEET    1 AH9 2 ILE 7  84  PHE 7  85  0                                        
SHEET    2 AH9 2 LEU 7 118  THR 7 119 -1  O  THR 7 119   N  ILE 7  84           
SHEET    1 AI1 6 ILE 7 407  SER 7 408  0                                        
SHEET    2 AI1 6 LEU 7 362  LEU 7 364  1  N  VAL 7 363   O  SER 7 408           
SHEET    3 AI1 6 LEU 7 437  ASP 7 441  1  O  ILE 7 439   N  LEU 7 362           
SHEET    4 AI1 6 CYS 7 462  LEU 7 466  1  O  LEU 7 464   N  MET 7 438           
SHEET    5 AI1 6 VAL 7 337  ILE 7 338  1  N  ILE 7 338   O  GLY 7 465           
SHEET    6 AI1 6 LYS 7 487  TYR 7 489  1  O  LEU 7 488   N  VAL 7 337           
SHEET    1 AI2 6 ILE 7 605  ILE 7 607  0                                        
SHEET    2 AI2 6 ILE 7 558  PHE 7 561  1  N  VAL 7 560   O  ILE 7 607           
SHEET    3 AI2 6 VAL 7 622  GLN 7 625  1  O  ILE 7 624   N  PHE 7 561           
SHEET    4 AI2 6 PHE 7 659  SER 7 664  1  O  LEU 7 662   N  GLN 7 625           
SHEET    5 AI2 6 CYS 7 507  CYS 7 512  1  N  VAL 7 510   O  SER 7 661           
SHEET    6 AI2 6 VAL 7 689  ILE 7 690  1  O  ILE 7 690   N  GLU 7 509           
SHEET    1 AI3 3 ASP 8  16  PHE 8  17  0                                        
SHEET    2 AI3 3 ALA 8  24  ARG 8  30 -1  O  LYS 8  28   N  ASP 8  16           
SHEET    3 AI3 3 ILE 8  37  ILE 8  43 -1  O  ILE 8  40   N  TYR 8  27           
SHEET    1 AI4 2 ILE 8 133  HIS 8 135  0                                        
SHEET    2 AI4 2 ALA 8 159  SER 8 161 -1  O  LYS 8 160   N  LEU 8 134           
SHEET    1 AI5 2 LEU 8 144  LEU 8 145  0                                        
SHEET    2 AI5 2 LEU 8 151  LYS 8 152 -1  O  LYS 8 152   N  LEU 8 144           
LINK         SG  CYS A  74                ZN    ZN A2002     1555   1555  2.87  
LINK         SG  CYS A  81                ZN    ZN A2002     1555   1555  2.54  
LINK         NE2 HIS A  84                ZN    ZN A2002     1555   1555  2.63  
LINK         SG  CYS A 111                ZN    ZN A2003     1555   1555  2.95  
LINK         O   CYS A 184                ZN    ZN A2003     1555   1555  2.56  
LINK         OD1 ASP A 495                MG    MG B1201     1555   1555  2.76  
LINK         OD2 ASP A 495                MG    MG A2001     1555   1555  2.62  
LINK         OD2 ASP A 499                MG    MG A2001     1555   1555  2.66  
LINK         OE1 GLU B 791                MG    MG B1201     1555   1555  2.87  
LINK         OE2 GLU B 791                MG    MG B1201     1555   1555  2.99  
LINK         SG  CYS B1119                ZN    ZN B1202     1555   1555  2.80  
LINK         SG  CYS B1122                ZN    ZN B1202     1555   1555  2.59  
LINK         SG  CYS C  88                ZN    ZN C 301     1555   1555  2.69  
LINK         SG  CYS C  94                ZN    ZN C 301     1555   1555  2.58  
LINK         SG  CYS I  20                ZN    ZN I 201     1555   1555  2.57  
LINK         SG  CYS I  42                ZN    ZN I 201     1555   1555  2.73  
LINK         SG  CYS I 114                ZN    ZN I 202     1555   1555  2.65  
LINK         SG  CYS J  10                ZN    ZN J 101     1555   1555  2.57  
LINK         SG  CYS J  44                ZN    ZN J 101     1555   1555  2.76  
LINK         SG  CYS L  19                ZN    ZN L 101     1555   1555  2.61  
LINK         SG  CYS L  36                ZN    ZN L 101     1555   1555  2.61  
LINK         SG  CYS M  15                ZN    ZN M 401     1555   1555  2.55  
LINK         NE2 HIS M  18                ZN    ZN M 401     1555   1555  2.45  
LINK         SG  CYS M  37                ZN    ZN M 401     1555   1555  2.61  
LINK         SG  CYS Q 129                ZN    ZN Q 501     1555   1555  2.61  
LINK         SG  CYS Q 132                ZN    ZN Q 501     1555   1555  2.65  
LINK         SG  CYS Q 154                ZN    ZN Q 501     1555   1555  2.59  
LINK         SG  CYS U 263                ZN    ZN U 401     1555   1555  2.68  
LINK         SG  CYS U 291                ZN    ZN U 401     1555   1555  2.64  
LINK         SG  CYS U 294                ZN    ZN U 401     1555   1555  2.58  
LINK         SG  CYS 0 116                FE1  SF4 01000     1555   1555  2.18  
LINK         SG  CYS 0 134                FE3  SF4 01000     1555   1555  2.31  
LINK         SG  CYS 0 155                FE2  SF4 01000     1555   1555  2.28  
LINK         SG  CYS 0 190                FE4  SF4 01000     1555   1555  2.22  
LINK         SG  CYS 3   6                ZN    ZN 3 401     1555   1555  2.49  
LINK         SG  CYS 3   9                ZN    ZN 3 401     1555   1555  2.50  
LINK         SG  CYS 3  26                ZN    ZN 3 402     1555   1555  2.96  
LINK         SG  CYS 3  31                ZN    ZN 3 401     1555   1555  2.48  
LINK         SG  CYS 3  34                ZN    ZN 3 401     1555   1555  2.50  
LINK         SG  CYS 3  46                ZN    ZN 3 402     1555   1555  2.64  
LINK         SG  CYS 3  49                ZN    ZN 3 402     1555   1555  2.63  
LINK         SG  CYS 4 271                ZN    ZN 4 401     1555   1555  2.96  
LINK         SG  CYS 4 285                ZN    ZN 4 401     1555   1555  2.54  
LINK         SG  CYS 6 291                ZN    ZN 6 403     1555   1555  2.95  
LINK         SG  CYS 6 345                ZN    ZN 6 401     1555   1555  2.50  
LINK         SG  CYS 6 348                ZN    ZN 6 401     1555   1555  2.68  
LINK         SG  CYS 6 360                ZN    ZN 6 402     1555   1555  2.85  
LINK         SG  CYS 6 363                ZN    ZN 6 402     1555   1555  2.91  
LINK         SG  CYS 6 368                ZN    ZN 6 401     1555   1555  2.50  
LINK         SG  CYS 6 371                ZN    ZN 6 401     1555   1555  2.52  
LINK         SG  CYS 6 382                ZN    ZN 6 402     1555   1555  2.74  
LINK         SG  CYS 6 385                ZN    ZN 6 402     1555   1555  2.79  
CISPEP   1 GLN A  461    PRO A  462          0         0.98                     
CISPEP   2 LYS A  581    PRO A  582          0        -2.31                     
CISPEP   3 MET S   62    PRO S   63          0        -1.62                     
CISPEP   4 VAL 1  211    PRO 1  212          0        -1.98                     
CISPEP   5 TYR 4   71    PRO 4   72          0        -0.89                     
CISPEP   6 LYS 9   72    PRO 9   73          0        -1.04                     
SITE     1 AC1  4 ASN A 493  ALA A 494  ASP A 495  ASP A 499                    
SITE     1 AC2  4 GLN A  72  CYS A  74  CYS A  81  HIS A  84                    
SITE     1 AC3  4 CYS A 111  CYS A 114  CYS A 154  CYS A 184                    
SITE     1 AC4  3 ALA A 494  ASP A 495  GLU B 791                               
SITE     1 AC5  2 CYS B1119  CYS B1122                                          
SITE     1 AC6  4 CYS C  88  CYS C  90  CYS C  94  CYS C  97                    
SITE     1 AC7  5 CYS I  20  LEU I  24  CYS I  39  ASN I  41                    
SITE     2 AC7  5 CYS I  42                                                     
SITE     1 AC8  1 CYS I 114                                                     
SITE     1 AC9  4 CYS J   7  CYS J  10  CYS J  44  CYS J  45                    
SITE     1 AD1  5 CYS L  19  CYS L  22  CYS L  36  ARG L  37                    
SITE     2 AD1  5 CYS L  39                                                     
SITE     1 AD2  5 CYS M  15  HIS M  18  CYS M  34  GLU M  36                    
SITE     2 AD2  5 CYS M  37                                                     
SITE     1 AD3  5 CYS Q 129  CYS Q 132  CYS Q 154  CYS Q 157                    
SITE     2 AD3  5 THR Q 159                                                     
SITE     1 AD4  5 CYS U 263  CYS U 266  CYS U 291  GLU U 293                    
SITE     2 AD4  5 CYS U 294                                                     
SITE     1 AD5  8 LEU 0 115  CYS 0 116  HIS 0 118  CYS 0 134                    
SITE     2 AD5  8 CYS 0 155  PHE 0 157  CYS 0 190  PHE 0 193                    
SITE     1 AD6  5 CYS 3   6  CYS 3   9  CYS 3  31  SER 3  33                    
SITE     2 AD6  5 CYS 3  34                                                     
SITE     1 AD7  4 CYS 3  26  HIS 3  28  CYS 3  46  CYS 3  49                    
SITE     1 AD8  4 GLN 1 355  CYS 4 268  CYS 4 271  CYS 4 285                    
SITE     1 AD9  4 CYS 6 345  CYS 6 348  CYS 6 368  CYS 6 371                    
SITE     1 AE1  4 CYS 6 360  CYS 6 363  CYS 6 382  CYS 6 385                    
SITE     1 AE2  4 CYS 6 291  CYS 6 294  ILE 6 307  CYS 6 308                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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